Faculty Collaboration Database

HDC gene polymorphisms are associated with age at natural menopause in Caucasian women. Biochem Biophys Res Commun 2006 Oct 06;348(4):1378-82

Date

08/22/2006

Pubmed ID

16919600

Pubmed Central ID

PMC1803761

DOI

10.1016/j.bbrc.2006.08.008

Scopus ID

2-s2.0-33748136965 (requires institutional sign-in at Scopus site)   18 Citations

Abstract

Histidine decarboxylase gene (HDC) encodes histidine decarboxylase which is the crucial enzyme for the biosynthesis of histidine. Studies have shown that histamine is likely to be involved in the regulation of reproduction system. To find the possible correlation between HDC gene and AANM (age at natural menopause), we selected 265 postmenopausal women from 131 nuclear families and performed a transmission disequilibrium test. Significant within-family associations with AANM for SNP rs854163 and SNP rs854158 of HDC gene were observed (P values=0.0018 and 0.0197, respectively). After 1000 permutations, SNP rs854163 still remained significant within-family association with AANM. Consistently, we also detected a significant within-family association between haplotype block 2 (defined by SNP rs854163 and rs860526) and AANM in the haplotype analyses (P value=0.0397). Our results suggest that the HDC gene polymorphisms are significantly associated with AANM in Caucasian women.

Author List

Zhang F, Xiong DH, Wang W, Shen H, Xiao P, Yang F, Recker RR, Deng HW

MESH terms used to index this publication - Major topics in bold

Age Factors
Female
Histidine Decarboxylase
Humans
Linkage Disequilibrium
Menopause
Middle Aged
Polymorphism, Single Nucleotide