Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J mice. Neoplasia 2007 May;9(5):401-5
Date
05/31/2007Pubmed ID
17534445Pubmed Central ID
PMC1877981DOI
10.1593/neo.07160Scopus ID
2-s2.0-34249002243 (requires institutional sign-in at Scopus site) 44 CitationsAbstract
Effective chemoprevention of lung cancer in high-risk patients through the administration of pharmacologic or nutritional agents is urgently needed. Aerosol inhalation can deliver chemopreventive agents directly to the respiratory tract to inhibit the tumorigenic process. In this study, polyphenon E (PolyE) and (-)-epigallocatechin-3-gallate (EGCG) were administered by aerosol delivery to A/J mice beginning 2 weeks after carcinogen treatment and continuing daily by inhalation throughout the remainder of the study (20 weeks). PolyE decreased tumor load by approximately 59%. However, EGCG, both at the same dose and at a higher dose, failed to inhibit lung carcinogenesis. These results indicate that aerosol delivery of PolyE, but not EGCG, may be a useful chemopreventive protocol in subjects at high risk for lung cancer.
Author List
Yan Y, Cook J, McQuillan J, Zhang G, Hitzman CJ, Wang Y, Wiedmann TS, You MMESH terms used to index this publication - Major topics in bold
AerosolsAnimals
Anticarcinogenic Agents
Benzo(a)pyrene
Catechin
Female
Lung Neoplasms
Mice