Faculty Collaboration Database

Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in caucasian females. Hum Reprod 2007 Jun;22(6):1789-94

Date

03/23/2007

Pubmed ID

17376820

DOI

10.1093/humrep/dem052

Scopus ID

2-s2.0-34447308215 (requires institutional sign-in at Scopus site)   40 Citations

Abstract

BACKGROUND: The insulin-like growth factor 1 (IGF1) gene, which plays a crucial role in hypothalamic-pituitary-ovarian hormone-controlled metabolic processes, may influence the onset of menarche. Our study aimed to test association between IGF1 polymorphisms with the variation of age at menarche (AAM) in Caucasian females.

METHODS: We recruited a sample of 1048 females from 354 Caucasian nuclear families and genotyped 19 single-nucleotide polymorphisms (SNPs) spanning the entire IGF1 gene. Pairwise linkage disequilibrium among SNPs was measured, and the haplotype blocks were inferred. Both single SNP markers and haplotypes were tested for association with AAM using the quantitative transmission disequilibrium test.

RESULTS: Significant association (P = 0.0153) between AAM and SNP3 (rs6214) in block1 was detected.

CONCLUSIONS: Our results suggested a potential effect of SNP3 in the IGF1 gene on AAM variation in Caucasian women for the first time. However, further independent studies are needed to confirm our findings.

Author List

Zhao J, Xiong DH, Guo Y, Yang TL, Recker RR, Deng HW

MESH terms used to index this publication - Major topics in bold

Adult
Age Factors
Aged
Aged, 80 and over
Female
Gene Frequency
Haplotypes
Humans
Insulin-Like Growth Factor I
Linkage Disequilibrium
Menarche
Middle Aged
Polymorphism, Single Nucleotide