The impact of overexpression and deficiency of fatty acid translocase (FAT)/CD36. Mol Cell Biochem 2002 Oct;239(1-2):193-7
Date
12/14/2002Pubmed ID
12479585DOI
10.1023/A:1020515210972Scopus ID
2-s2.0-0036813391 (requires institutional sign-in at Scopus site) 73 CitationsAbstract
Fatty acid translocase (FAT)/CD36 has been associated with diverse normal and pathologic processes. These include scavenger receptor functions (uptake of apoptotic cells and modified lipid), lipid metabolism and fatty acid transport, adhesion, angiogenesis, modulation of inflammation, transforming growth factor-beta activation, atherosclerosis, diabetes and cardiomyopathy. Although CD36 was identified more than 25 years ago, it is only with the advent of recent genetic technology that in vivo evidence has emerged for its physiologic and pathologic relevance. As these in vivo studies are expanded, we will gain further insight into the mechanism(s) by which CD36 transmits a cellular signal, and this will allow the design of specific therapeutics that impact on a particular function of CD36.
Author List
Febbraio M, Guy E, Coburn C, Knapp FF Jr, Beets AL, Abumrad NA, Silverstein RLAuthor
Roy L. Silverstein MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdipocytesAnimals
CD36 Antigens
Disease Models, Animal
Fatty Acids
Humans
Membrane Glycoproteins
Organic Anion Transporters
