A genomic-systems biology map for cardiovascular function. Science 2001 Nov 23;294(5547):1723-6
Date
11/27/2001Pubmed ID
11721057DOI
10.1126/science.1062117Scopus ID
2-s2.0-0035940943 (requires institutional sign-in at Scopus site) 151 CitationsAbstract
With the draft sequence of the human genome available, there is a need to better define gene function in the context of systems biology. We studied 239 cardiovascular and renal phenotypes in 113 male rats derived from an F2 intercross and mapped 81 of these traits onto the genome. Aggregates of traits were identified on chromosomes 1, 2, 7, and 18. Systems biology was assessed by examining patterns of correlations ("physiological profiles") that can be used for gene hunting, mechanism-based physiological studies, and, with comparative genomics, translating these data to the human genome.
Author List
Stoll M, Cowley AW Jr, Tonellato PJ, Greene AS, Kaldunski ML, Roman RJ, Dumas P, Schork NJ, Wang Z, Jacob HJAuthor
Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBlood Pressure
Cardiovascular Physiological Phenomena
Chromosome Mapping
Chromosomes
Crosses, Genetic
Female
Genomics
Humans
Kidney
Lod Score
Male
Nitric Oxide Synthase
Norepinephrine
Phenotype
Quantitative Trait, Heritable
Rats
Vasodilation
