14, 15-Epoxyeicosatrienoic acid promotes endothelial cell dependent adhesion of human monocytic tumor U937 cells. Biochem Biophys Res Commun 1990 Feb 28;167(1):137-42
Date
02/28/1990Pubmed ID
2310385DOI
10.1016/0006-291x(90)91741-aScopus ID
2-s2.0-0025253159 (requires institutional sign-in at Scopus site) 33 CitationsAbstract
Arachidonic acid (AA) can be metabolized in endothelial cells (EC) to a series of epoxides via cytochrome P-450 epoxygenase with 14,15 epoxyeicosatrienoic acid (14,15-EET) as the major product. In this communication we report that 14,15-EET significantly enhances U937 cell attachment to EC with maximal cell attachment at 2.5 to 5 x 10(-7) M 14,15-EET. Thus, 14,15-EET may play a substantial role in inflammation and/or atherogenesis by inducing monocyte attachment to EC.
Author List
Pritchard KA Jr, Tota RR, Stemerman MB, Wong PYAuthor
Kirkwood A. Pritchard PhD Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
8,11,14-Eicosatrienoic AcidCell Adhesion
Cells, Cultured
Chromatography, High Pressure Liquid
Endothelium
Fatty Acids, Unsaturated
Fluorescent Dyes
Humans
L-Lactate Dehydrogenase
Prostaglandins
Thrombin
Tumor Cells, Cultured