The glomerulo-tubular junction: a target in renal diseases. J Pathol 2002 May;197(1):1-3
Date
06/26/2002Pubmed ID
12081194DOI
10.1002/path.1087Scopus ID
2-s2.0-0036242147 (requires institutional sign-in at Scopus site) 18 CitationsAbstract
Both global and segmental glomerulopathies may damage specific areas of the renal glomerulus. Diseases associated with glomerular hyperperfusion cause lesions at the vascular pole, while diseases associated with proteinuria often damage the tubular pole. Atubular glomeruli are now known to be plentiful in a variety of common renal diseases. These glomeruli are disconnected from their tubule at the tubular pole and therefore cannot participate in the production of urine. It is widely believed that the disconnection is a result of external compression by periglomerular fibrosis. However, the variable anatomy and cell populations within both the glomerulus and the beginning of the proximal tubule at the glomerulo-tubular junction may also have important roles to play in the response to damage at this sensitive site of the nephron.
Author List
Lindop GB, Gibson IW, Downie TT, Vass D, Cohen EPMESH terms used to index this publication - Major topics in bold
HumansKidney Diseases
Kidney Glomerulus
Kidney Tubules
