Evaluation of 70/30 poly (L-lactide-co-D,L-lactide) for use as a resorbable interbody fusion cage. J Neurosurg 2002 Nov;97(4 Suppl):423-32
Date
11/27/2002Pubmed ID
12449196DOI
10.3171/spi.2002.97.4.0423Scopus ID
2-s2.0-0036829097 (requires institutional sign-in at Scopus site) 44 CitationsAbstract
OBJECT: Titanium lumbar interbody spinal fusion devices are reported to be 90% effective in cases requiring single-level lumbar interbody arthrodesis, although radiographic determination of fusion has been debated.
METHODS: Using blinded radiographic, biomechanical, histological, and statistical measures, researchers in the present study evaluated a radiolucent 70/30 poly(L-lactide-co-D,L-lactide) interbody fusion device packed with autograft or recombinant human bone morphogenetic protein-2 on a collagen sponge in 25 sheep at 3, 6, 12, 18, and 24 months. A trend of increased fusion stiffness, radiographic fusion, and histologically confirmed fusion was demonstrated at 3 months to 24 months postimplantation. Device degradation was associated with a mild to moderate chronic inflammatory response at all postoperative sacrifice times.
CONCLUSIONS: Use of this material in interbody fusion may be a viable alternative to metals.
Author List
Toth JM, Estes BT, Wang M, Seim HB 3rd, Scifert JL, Turner AS, Cornwall GBAuthors
Jeffrey M. Toth PhD Associate Dean for Research in the School of Dentistry department at Marquette UniversityMei Wang PhD Associate Professor in the Orthopaedic Surgery department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Absorbable ImplantsAnimals
Biocompatible Materials
Biomechanical Phenomena
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins
Diffusion Chambers, Culture
Disease Models, Animal
Evaluation Studies as Topic
Humans
Lumbar Vertebrae
Polyesters
Radiography
Recombinant Proteins
Recovery of Function
Sheep
Spinal Fusion
Spinal Injuries
Time Factors
Transforming Growth Factor beta
