Effect of annual influenza immunization on antibody response in lung transplant patients. Prog Transplant 2009 Jun;19(2):153-9
Date
07/11/2009Pubmed ID
19588665Pubmed Central ID
PMC2872508DOI
10.1177/152692480901900209Scopus ID
2-s2.0-70349257399 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
BACKGROUND: Influenza viral infections cause significant morbidity and mortality each season. Lung transplant patients may be at higher risk because of their underlying pathophysiology. Although annual immunization is the standard of care, its efficacy remains largely unproven. Previous studies showed poor antibody response to influenza vaccine in lung transplant patients, but no data on the antibody response in consecutive seasons have been published.
METHODS: We studied antibody responses to influenza vaccine in 122 subjects: 66 lung transplant recipients, 28 control subjects, and 28 patients awaiting lung transplantation. We compared antibody response rates to individual viruses contained in influenza vaccines in consecutive years within the 3 groups. Serum antibody concentrations were measured at baseline and 2 to 4 weeks after vaccination by using the hemagglutination inhibition assay. Log-transformed antibody concentrations and incidence of serconversion and seroprotection were calculated.
RESULTS: Median log-transformed antibody responses were similar in consecutive seasons in lung transplant subjects. Incidences of seroprotection and seroconversion did not differ between consecutive seasons in lung transplant recipients.
CONCLUSIONS: Antibody responses were similar in consecutively measured years in lung transplant subjects. Annual influenza vaccination in lung transplant subjects produces similar immune responses in 2 consecutive years, indicating that these patients are not at significantly increased risk of vaccine failure.
Author List
Dopp JM, Wiegert NA, Moran JJ, Francois ML, Radford KL, Thomas H, Love RB, Hayney MSMESH terms used to index this publication - Major topics in bold
AdultAntibodies, Viral
Case-Control Studies
Child
Female
Humans
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H3N2 Subtype
Influenza B virus
Influenza Vaccines
Influenza, Human
Lung Transplantation
Male
Middle Aged
Statistics, Nonparametric
Time Factors
Transplantation Immunology
Treatment Outcome
Vaccination
Wisconsin