Septal nuclei enlargement in human temporal lobe epilepsy without mesial temporal sclerosis. Neurology 2013 Jan 29;80(5):487-91
Date
01/11/2013Pubmed ID
23303846Pubmed Central ID
PMC3590047DOI
10.1212/WNL.0b013e31827f0ed7Scopus ID
2-s2.0-84873672279 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
OBJECTIVE: To measure the volume of basal forebrain septal nuclei in patients with temporal lobe epilepsy (TLE) as compared to patients with extratemporal epilepsy and controls. In animal models of TLE, septal lesions facilitate epileptogenesis, while septal stimulation is antiepileptic.
METHOD: Subjects were recruited from 2 sites and consisted of patients with pharmacoresistant focal epilepsy (20 with TLE and mesial temporal sclerosis [MTS], 24 with TLE without MTS, 23 with extratemporal epilepsy) and 114 controls. Septal volume was measured using high-resolution MRI in association with newly developed probabilistic septal nuclei maps. Septal volume was compared between subject groups while controlling for relevant factors.
RESULTS: Patients with TLE without MTS had significantly larger septal nuclei than patients with extratemporal epilepsy and controls. This was not true for patients with MTS. These results are interpreted with reference to prior studies demonstrating expansion of the septo-hippocampal cholinergic system in animal models of TLE and human TLE surgical specimens.
CONCLUSION: Septal nuclei are enlarged in patients with TLE without MTS. Further investigation of septal nuclei and antiepileptic septo-hippocampal neurocircuitry could be relevant to development of new therapeutic interventions such as septal stimulation for refractory TLE.
Author List
Butler T, Zaborszky L, Wang X, McDonald CR, Blackmon K, Quinn BT, DuBois J, Carlson C, Barr WB, French J, Kuzniecky R, Halgren E, Devinsky O, Thesen TAuthor
Chad Carlson MD Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Epilepsy, Temporal Lobe
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Sclerosis
Septal Nuclei
Statistics as Topic
Temporal Lobe
Young Adult