Faculty Collaboration Database

Donor and recipient BKV-specific IgG antibody and posttransplantation BKV infection: a prospective single-center study. Transplantation 2013 Mar 27;95(6):896-902

Date

03/21/2013

Pubmed ID

23511214

DOI

10.1097/TP.0b013e318282ba83

Scopus ID

2-s2.0-84877588361 (requires institutional sign-in at Scopus site)   45 Citations

Abstract

BACKGROUND: The study evaluated the relationship of pretransplantation BK virus (BKV)-specific donor and recipient serostatus to posttransplantation BKV infection.

METHODS: Two hundred forty adult de novo kidney-only recipients and 15 pediatric recipients were prospectively enrolled and followed for a minimum of 18 months. Pretransplantation BKV serostatus was available for 192 adult and 11 pediatric donor-recipient pairs. Based on BKV-specific IgG enzyme immunoassay ≥8 units, subjects were divided into four groups: D+R+, D+R-, D-R+, and D-R-. BKV DNA surveillance was performed at 1, 3, 6, 12, and 24 months. The outcomes studied were development of any BKV infection, viremia, and significant viremia (≥10,000 copies/mL plasma).

RESULTS: Of the 192 adult subjects (D+R- [n=41], D+R+ [n=42], D-R+ [n=41], and D-R- [n=68]), 89 of 192 developed any BKV infection and 62 of 89 developed BK insignificant viremia (n=33) and significant viremia (n=29). Any BKV infection developed in 25 of 41, 22 of 42, 17 of 41, and 25 of 68 in the D+R-, D+R+, D-R+, and D-R- groups, respectively. Any viremia (20 of 41) and significant viremia (10 of 41) seen in the D+R- group was significantly higher than other groups (P=0.014). In 11 pediatric recipients, infection was seen only in the D+R- group. Overall, infection was highest in the D+R- group and lowest in the D-R- group.

CONCLUSIONS: BKV serostatus can be used to risk stratify patients for posttransplantation infection.

Author List

Sood P, Senanayake S, Sujeet K, Medipalli R, Van-Why SK, Cronin DC, Johnson CP, Hariharan S

Authors

Christopher P. Johnson MD Professor in the Surgery department at Medical College of Wisconsin
Scott K. Van Why MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Antibodies
BK Virus
Child
Enzyme-Linked Immunosorbent Assay
Female
Graft Rejection
Humans
Immunoglobulin G
Male
Middle Aged
Polyomavirus Infections
Postoperative Complications
Prospective Studies
Transplantation
Treatment Outcome
Tumor Virus Infections
Viremia