S-nitrosoglutathione. Biochim Biophys Acta 2013 May;1830(5):3173-81
Date
02/19/2013Pubmed ID
23416062Pubmed Central ID
PMC3679660DOI
10.1016/j.bbagen.2013.02.004Scopus ID
2-s2.0-84875738207 (requires institutional sign-in at Scopus site) 264 CitationsAbstract
BACKGROUND: S-Nitrosoglutathione (GSNO) is the S-nitrosated derivative of glutathione and is thought to be a critical mediator of the down stream signaling effects of nitric oxide (NO). GSNO has also been implicated as a contributor to various disease states.
SCOPE OF REVIEW: This review focuses on the chemical nature of GSNO, its biological activities, the evidence that it is an endogenous mediator of NO action, and implications for therapeutic use.
MAJOR CONCLUSIONS: GSNO clearly exerts its cellular actions through both NO- and S-nitrosation-dependent mechanisms; however, the chemical and biological aspects of this compound should be placed in the context of S-nitrosation as a whole.
GENERAL SIGNIFICANCE: GSNO is a central intermediate in formation and degradation of cellular S-nitrosothiols with potential therapeutic applications; thus, it remains an important molecule of study. This article is part of a Special Issue entitled Cellular functions of glutathione.
Author List
Broniowska KA, Diers AR, Hogg NAuthor
Neil Hogg PhD Associate Dean, Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsGlutathione
Humans
Nitric Oxide
Nitrosation
S-Nitrosoglutathione
S-Nitrosothiols
