The reaction between nitrite and hemoglobin: the role of nitrite in hemoglobin-mediated hypoxic vasodilation. J Inorg Biochem 2005 Jan;99(1):237-46
Date
12/16/2004Pubmed ID
15598504DOI
10.1016/j.jinorgbio.2004.10.034Scopus ID
2-s2.0-10444220188 (requires institutional sign-in at Scopus site) 152 CitationsAbstract
The reaction between nitrite and hemoglobin has been studied for over a century. However, recent evidence indicating nitrite is a latent vasodilatory agent that can be activated by its reaction with deoxyhemoglobin has led to renewed interest in this reaction. In this review we survey, in the context of our own recent studies, the chemical reactivity of nitrite with oxyhemoglobin, deoxyhemoglobin and methemoglobin, and place these reactions in both a physiological and pharmacological/therapeutic context.
Author List
Kim-Shapiro DB, Gladwin MT, Patel RP, Hogg NAuthor
Neil Hogg PhD Associate Dean, Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsHemoglobins
Humans
Hypoxia
Nitrites
Oxygen
Vasodilation