A comparison of some pharmacological actions of morphine and delta9-tetrahydrocannabinol in the mouse. Psychopharmacology (Berl) 1978 May 31;57(3):243-8
Date
05/31/1978Pubmed ID
97703DOI
10.1007/BF00426745Scopus ID
2-s2.0-0018154549 (requires institutional sign-in at Scopus site) 83 CitationsAbstract
The effects of morphine and delta9-tetrahydrocannabinol(THC)on the tail-flick reflex, body temperature, and catecholamine synthesis were examined in the mouse in order to compare their effects in a single species and strain under uniform conditions. Naloxone antagonism of THC and cross-tolerance between morphine and THC were also studied. Both morphine and THC produced antinociception, hypothermia, and increased catecholamine synthesis at 30 min after s.c. injection. Morphine produced greater increases in dopamine synthesis and was a more potent antinociceptive agent, while THC produced greater increases in norepinephrine synthesis and was a more potent hypothermic agent. Naloxone pretreatment (1 mg/kg) partially antagonized the hypothermia and increase in catecholamine synthesis produced by THC. There was also cross-tolerance between morphine and THC, but it was asymmetric in that THC-tolerant animals were cross-tolerant to only the hypothermic action of morphine and morphine-tolerant animals cross-tolerant to only the antinociceptive action of THC.
Author List
Bloom AS, Dewey WLMESH terms used to index this publication - Major topics in bold
AnalgesicsAnimals
Body Temperature
Brain Chemistry
Catecholamines
Dronabinol
Drug Tolerance
Male
Mice
Mice, Inbred ICR
Morphine
Naloxone
Reaction Time
