Axial stent strut angle influences wall shear stress after stent implantation: analysis using 3D computational fluid dynamics models of stent foreshortening. Biomed Eng Online 2005 Oct 26;4:59
Date
10/28/2005Pubmed ID
16250918Pubmed Central ID
PMC1276824DOI
10.1186/1475-925X-4-59Scopus ID
2-s2.0-27744458817 (requires institutional sign-in at Scopus site) 50 CitationsAbstract
INTRODUCTION: The success of vascular stents in the restoration of blood flow is limited by restenosis. Recent data generated from computational fluid dynamics (CFD) models suggest that the vascular geometry created by an implanted stent causes local alterations in wall shear stress (WSS) that are associated with neointimal hyperplasia (NH). Foreshortening is a potential limitation of stent design that may affect stent performance and the rate of restenosis. The angle created between axially aligned stent struts and the principal direction of blood flow varies with the degree to which the stent foreshortens after implantation.
METHODS: In the current investigation, we tested the hypothesis that stent foreshortening adversely influences the distribution of WSS and WSS gradients using time-dependent 3D CFD simulations of normal arteries based on canine coronary artery measurements of diameter and blood flow. WSS and WSS gradients were calculated using conventional techniques in ideal (16 mm) and progressively foreshortened (14 and 12 mm) stented computational vessels.
RESULTS: Stent foreshortening increased the intrastrut area of the luminal surface exposed to low WSS and elevated spatial WSS gradients. Progressive degrees of stent foreshortening were also associated with strut misalignment relative to the direction of blood flow as indicated by analysis of near-wall velocity vectors.
CONCLUSION: The current results suggest that foreshortening may predispose the stented vessel to a higher risk of neointimal hyperplasia.
Author List
LaDisa JF Jr, Olson LE, Hettrick DA, Warltier DC, Kersten JR, Pagel PSAuthor
John F. LaDisa PhD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsArteries
Blood Flow Velocity
Blood Pressure
Blood Vessel Prosthesis
Computer Simulation
Computer-Aided Design
Elasticity
Equipment Failure Analysis
Humans
Imaging, Three-Dimensional
Models, Cardiovascular
Prosthesis Design
Prosthesis Implantation
Shear Strength
Stents
Stress, Mechanical
