Chemokine expression in the central nervous system of mice with a viral disease resembling multiple sclerosis: roles of CD4+ and CD8+ T cells and viral persistence. J Virol 2002 Mar;76(5):2217-24
Date
02/12/2002Pubmed ID
11836399Pubmed Central ID
PMC153814DOI
10.1128/jvi.76.5.2217-2224.2002Scopus ID
2-s2.0-0036173550 (requires institutional sign-in at Scopus site) 43 CitationsAbstract
During the first 45 days after intracerebral infection with Theiler's murine encephalomyelitis virus (TMEV), the levels of mRNAs encoding chemokines MCP-1/CCL2, RANTES/CCL5, and IP-10/CXCL10 in the central nervous system (CNS) are closely related to the sites of virus gene expression and tissue inflammation. In the present study, these chemokines were monitored during the latter 135 days of a 6-month course of TMEV-induced disease in susceptible (PLJ) or resistant (C57BL/6) mice that possessed or lacked either CD4+ or CD8+ T cells. These data were additionally correlated to mouse genotype, virus persistence in the CNS, antiviral antibody titers, mortality, and the severity of neurological disease. Surprisingly, the major determinant of chemokine expression was virus persistence: the factors of susceptible or resistant genotype, severity of neuropathology, and presence or absence of regulatory T cells exerted minimal effects. Our observations indicated that chemokine expression in the CNS in this chronic viral disorder was intrinsic to the CNS innate immune response to infection and was not governed by elements of the adaptive immune system.
Author List
Ransohoff RM, Wei T, Pavelko KD, Lee JC, Murray PD, Rodriguez MAuthor
Paul D. Harker-Murray MD, PhD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cardiovirus Infections
Central Nervous System
Chemokines
Humans
Mice
Mice, Inbred C57BL
Multiple Sclerosis
Spinal Cord
Theilovirus
Virus Replication
