Faculty Collaboration Database

Vocal cord dysfunction related to water-damaged buildings. J Allergy Clin Immunol Pract 2013 Jan;1(1):46-50

Date

11/16/2013

Pubmed ID

24229821

DOI

10.1016/j.jaip.2012.10.001

Scopus ID

2-s2.0-84877998482 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

BACKGROUND: Vocal cord dysfunction (VCD) is the intermittent paradoxical adduction of the vocal cords during respiration, resulting in variable upper airway obstruction. Exposure to damp indoor environments is associated with adverse respiratory health outcomes, including asthma, but its role in the development of VCD is not well described.

OBJECTIVE: We describe the spectrum of respiratory illness in occupants of 2 water-damaged office buildings.

METHODS: The National Institute for Occupational Safety and Health conducted a health hazard evaluation that included interviews with managers, a maintenance officer, a remediation specialist who had evaluated the 2 buildings, employees, and consulting physicians. In addition, medical records and reports of building evaluations were reviewed. Diagnostic evaluations for VCD had been conducted at the Asthma and Allergy Center of the Medical College of Wisconsin.

RESULTS: Two cases of VCD were temporally related to occupancy of water-damaged buildings. The patients experienced cough, chest tightness, dyspnea, wheezing, and hoarseness when in the buildings. Spirometry was normal. Methacholine challenge did not show bronchial hyperreactivity but did elicit symptoms of VCD and inspiratory flow-volume loop truncation. Direct laryngoscopy revealed vocal cord adduction during inspiration. Coworkers developed upper and lower respiratory symptoms; their diagnoses included sinusitis and asthma, consistent with recognized effects of exposure to indoor dampness. Building evaluations provided evidence of water damage and mold growth.

CONCLUSION: VCD can occur with exposure to water-damaged buildings and should be considered in exposed patients with asthma-like symptoms.

Author List

Cummings KJ, Fink JN, Vasudev M, Piacitelli C, Kreiss K

MESH terms used to index this publication - Major topics in bold

Adult
Air Pollution, Indoor
Asthma
Bronchial Provocation Tests
Cough
Dyspnea
Female
Hoarseness
Humans
Inhalation Exposure
Laryngoscopy
Middle Aged
Mitosporic Fungi
Respiratory Sounds
Sinusitis
United States
Vocal Cord Dysfunction
Water