Medical College of Wisconsin
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Does histology predict outcome for malignant vascular tumors of the liver? J Surg Oncol 2014 Apr;109(5):483-6

Date

11/29/2013

Pubmed ID

24284733

DOI

10.1002/jso.23517

Scopus ID

2-s2.0-84897023041 (requires institutional sign-in at Scopus site)   36 Citations

Abstract

BACKGROUND AND OBJECTIVES: Malignant vascular tumors (MVT) of the liver are uncommon and poorly understood. We hypothesized that tumor histology is a predominant factor associated with survival in these tumors.

METHODS: Patients with malignant histopathologic diagnoses of hepatic angiosarcoma (AS), hemangioendothelioma (HE) and its epithelioid variant (EHE), or hemangiopericytoma (HP) were identified using the SEER database (1973-2007). Overall survival (OS) was studied with Kaplan-Meier curves.

RESULTS: We included 297 patients with MVT (207 AS, 28 HE, 56 EHE, 6 HP). All tumors demonstrated metastatic potential, although EHE and AS had the highest rate of regional or distant metastases (75% each). Patients with AS had the shortest median OS (1 month), however, those undergoing surgery had improved survival (6 months). Three patients with AS underwent liver transplant and lived for 11, 21, and 91 months each. Patients with EHE had the longest overall median survival of 75 months (30-183, P < 0.001). Surgical resection and transplant did not demonstrate an improvement in OS of patients with EHE in multivariable models.

CONCLUSIONS: Histology is an important factor in determining survival for patients with hepatic MVT. Patients with EHE have the longest OS, whereas patients with AS have shorter survival but may benefit from surgery.

Author List

Groeschl RT, Miura JT, Oshima K, Gamblin TC, Turaga KK

Author

Thomas Clark Gamblin MD Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Aged
Female
Hemangioendothelioma
Hemangiopericytoma
Hemangiosarcoma
Humans
Kaplan-Meier Estimate
Liver Neoplasms
Male
Middle Aged
Neoplasm Staging
Neoplasms, Vascular Tissue
Retrospective Studies
SEER Program
United States