Perils, problems, and progress in laboratory diagnosis of von Willebrand disease. Semin Thromb Hemost 2014 Feb;40(1):41-8
Date
12/18/2013Pubmed ID
24338593Pubmed Central ID
PMC3987108DOI
10.1055/s-0033-1363166Scopus ID
2-s2.0-84893041204 (requires institutional sign-in at Scopus site) 39 CitationsAbstract
Diagnosis of von Willebrand disease (VWD) merits consideration of personal and family history of bleeding symptoms along with confirmatory laboratory testing. As the latter yields quantifiable results, overreliance on a laboratory diagnosis may occur. However, existing tests for VWD contain potential sources for error. Both intrinsic and extrinsic factors affecting these assays can contribute to either falsely normal or falsely abnormal results. This article will discuss the present available assays as well as new developments in diagnostic testing. A clear understanding of the limitations of VWD testing is helpful for ensuring the correct diagnosis of affected patients.
Author List
Flood VHAuthor
Veronica H. Flood MD Interim Chief, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Clinical Laboratory TechniquesHumans
von Willebrand Diseases