Reye syndrome. A correlated electron-microscopic, viral, and biochemical observation. JAMA 1975 Jun 30;232(13):1339-46
Date
06/30/1975Pubmed ID
1173398DOI
10.1001/jama.232.13.1339Scopus ID
2-s2.0-85047690593 (requires institutional sign-in at Scopus site) 28 CitationsAbstract
Liver biopsy specimens of two patients with Reye syndrome were examined for ultrastructural features, viral isolation, and urea-cycle enzyme activity. Concurrent presence of herpes-like virus and myxovirus/paramyxovirus was demonstrated by electron microscopy, and viral infections were confirmed by isolation or serologic tests. A concomitant hepatic ornithine transcarbamoylase deficiency was also noted. The pathogenesis in these instances seems to consist of an initial synergistic insult on the liver by mixed types of viruses and subsequent breakdown of urea cycle, Krebs cycle, and possible other hepatic functions. An exodus of glycogen granules into the hepatic spaces of Disse and sinusoids suggests that the viruses have injured the plasma membranes as well as the mitochondria of hepatocytes. Since Kapila et al reported similar disorders five years before Reye et al, the name of Kapila-Reye disease is suggested.
Author List
Tang TT, Siegesmund KA, Sedmak GV, Casper JT, Varma RR, McCreadie SRMESH terms used to index this publication - Major topics in bold
AdolescentAmmonia
Antibodies, Viral
Antibody Formation
Autopsy
Biopsy, Needle
Brain Diseases
Child
Herpesviridae
Humans
Liver
Male
Ornithine Carbamoyltransferase Deficiency Disease
Orthomyxoviridae
Paramyxoviridae
Reye Syndrome
