Faculty Collaboration Database

Interface parameters of impact-induced mild traumatic brain injury. Biomed Sci Instrum 2006;42:108-13

Date

07/05/2006

Pubmed ID

16817594

Scopus ID

2-s2.0-33745191205 (requires institutional sign-in at Scopus site)   20 Citations

Abstract

Commonly considered a continuum of injuries, diffuse brain injury (DBI) ranges from mild concussion to severe diffuse axonal injury. The lower end of the spectrum is generally referred to as mild traumatic brain injury (MTBI). More severe forms of DBI have garnered extensive experimentation while these milder cases are considerably less explored. Recently, a new device was designed to generate DBI in the rodent using impact-induced angular acceleration. This device is modifiable so the entire spectrum of DBI can be investigated. Severity of DBI is critically dependent on magnitude of angular acceleration. A small animal surrogate like a rodent has a relatively small brain mass. This constraint poses a unique problem because the angular acceleration necessary for DBI is inversely related to brain mass. Prior experimentation estimated an angular acceleration of approximately 350 krad/s2 is necessary for the induction of mild traumatic brain injury (MTBI) in the rodent. To induce these magnitudes of angular acceleration in a repeatable manner, the impacting interface must be critically analyzed. This investigation uses a mathematical model based on parameters of a previously developed experimental model to assess the impacting interface such that angular accelerations are sufficient to produce MTBI in the rodent.

Author List

Fijalkowski RJ, Ellingson BM, Stemper BD, Yoganandan N, Gennarelli TA, Pintar FA

Authors

Frank A. Pintar PhD Chair, Professor in the Biomedical Engineering department at Medical College of Wisconsin
Brian Stemper PhD Professor in the Biomedical Engineering department at Medical College of Wisconsin
Narayan Yoganandan PhD Professor in the Neurosurgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acceleration
Animals
Biomechanical Phenomena
Brain Injuries
Computer Simulation
Disease Models, Animal
Equipment Design
Equipment Failure Analysis
Head Injuries, Closed
Models, Biological
Physical Stimulation
Rats