Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: a retrospective cohort study of 137 children with sickle cell anemia. J Pediatr 2006 Nov;149(5):710-2
Date
11/11/2006Pubmed ID
17095350DOI
10.1016/j.jpeds.2006.06.037Scopus ID
2-s2.0-33750614993 (requires institutional sign-in at Scopus site) 114 CitationsAbstract
A retrospective cohort study of children with sickle cell anemia (SCA) and strokes was used to test the hypothesis that exchange transfusion at the time of stroke presentation more effectively prevents second strokes than does simple transfusion. Children receiving simple transfusion had a 5-fold greater relative risk (95% confidence interval = 1.3 to 18.6) of second stroke than those receiving exchange transfusion.
Author List
Hulbert ML, Scothorn DJ, Panepinto JA, Scott JP, Buchanan GR, Sarnaik S, Fallon R, Chu JY, Wang W, Casella JF, Resar L, Berman B, Adamkiewicz T, Hsu LL, Smith-Whitley K, Mahoney D, Woods G, Watanabe M, DeBaun MRMESH terms used to index this publication - Major topics in bold
AdolescentAnemia, Sickle Cell
Blood Transfusion
Child
Child, Preschool
Disease-Free Survival
Exchange Transfusion, Whole Blood
Female
Follow-Up Studies
Humans
Infant
Male
Recurrence
Retrospective Studies
Risk Assessment
Risk Factors
Stroke
Time Factors
