Faculty Collaboration Database

Roles of epoxyeicosatrienoic acids in vascular regulation and cardiac preconditioning. J Cardiovasc Pharmacol 2007 Dec;50(6):601-8

Date

12/20/2007

Pubmed ID

18091575

DOI

10.1097/FJC.0b013e318159cbe3

Scopus ID

2-s2.0-36349001971 (requires institutional sign-in at Scopus site)   41 Citations

Abstract

Continuing investigations of the roles of cytochrome P450 (CYP) arachidonic acid epoxygenase metabolites in the regulation of cardiovascular physiology and pathophysiology have revealed their complex and diverse biological effects. Often these metabolites demonstrate protective properties that are revealed during cardiovascular disease. In this regard, the epoxyeicosatrienoic acids (EETs) are an emerging target for pharmacological manipulation aimed at enhancing their cardiac and vascular protective mechanisms. This review will focus on the role of EETs in the regulation of vascular tone, with emphasis on the coronary circulation, their role in limiting platelet aggregation, vascular inflammation and EET contribution to preconditioning of the ischemic myocardium. Production and metabolism of EETs as well as their specific cellular signaling mechanisms are discussed.

Author List

Gauthier KM, Yang W, Gross GJ, Campbell WB

Author

William B. Campbell PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

8,11,14-Eicosatrienoic Acid
Animals
Arachidonic Acid
Blood Vessels
Cardiovascular System
Eicosanoic Acids
Humans
Ischemic Preconditioning, Myocardial
Models, Biological
Signal Transduction