HTLV-III serology in hemophilia: relationship with immunologic abnormalities. J Pediatr 1986 Apr;108(4):511-6
Date
04/01/1986Pubmed ID
3083075DOI
10.1016/s0022-3476(86)80824-1Scopus ID
2-s2.0-0022619581 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
We investigated the relationship of the presence of antibodies to HTLV-III and immunologic abnormalities in patients with hemophilia. Serum antibodies to HTLV-III were analyzed by ELISA assay, immunoprecipitation of labeled cell extracts, and immunoprecipitation of purified HTLV-III p24. Thirty-four (61%) of the total group (n = 56) had antibody to HTLV-III; 34 (76%) of 45 patients given commercial factor VIII preparations were seropositive, compared with none of 11 patients treated exclusively with cryoprecipitate obtained from volunteer blood donors. Of patients who were seropositive for HTLV-III antibody, 94% had abnormal T4/T8 ratios, and 33% of those whose serum was antibody negative had abnormal T4/T8 ratios; five patients, each antibody positive, have lymphadenopathy syndrome. Sequential studies in a subset of patients indicate that there is a changing pattern of antibody production to HTLV-III antigens after seroconversion.
Author List
Gill JC, Menitove JE, Anderson PR, Casper JT, Devare SG, Wood C, Adair S, Casey J, Scheffel C, Montgomery RRAuthor
Robert R. Montgomery MD Adjunct Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Acquired Immunodeficiency SyndromeAntibodies, Viral
Antibody Formation
Cells, Cultured
Cryoglobulins
Drug Contamination
Enzyme-Linked Immunosorbent Assay
Factor VIII
HIV Antibodies
Hemophilia A
Humans
Iodine Radioisotopes
Leukocyte Count
Male
Platelet Count
T-Lymphocytes