Modulation of renal cell injury by heat shock proteins: lessons learned from the immature kidney. Nat Clin Pract Nephrol 2006 Mar;2(3):149-56
Date
08/26/2006Pubmed ID
16932413DOI
10.1038/ncpneph0117Scopus ID
2-s2.0-33644824121 (requires institutional sign-in at Scopus site) 10 CitationsAbstract
The mechanisms that underlie tolerance to injury in immature animals and tissues have been a subject of interest since 1670. Observations in neonatal units that premature infants are less prone to develop acute renal failure than adults in critical care units have prompted a series of investigations. Although initially attributed to metabolic adaptation such as increased glycolytic capacity and preservation of high energy phosphate, more recent studies have indicated a prominent role for the heat shock response. Observed modulations of injury by heat shock proteins in the immature kidney have significant implications for advancement of our understanding of renal cell injury in both adults and children.
Author List
Riordan M, Sreedharan R, Kashgarian M, Siegel NJAuthor
Rajasree Sreedharan MD Associate Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Acute Kidney InjuryAnimals
DNA-Binding Proteins
Heat Shock Transcription Factors
Heat-Shock Proteins
Humans
Infant, Newborn
Ischemic Preconditioning
Kidney
Reperfusion Injury
Transcription Factors
