Triglyceride-lowering effect of dietary vitamin E in streptozocin-induced diabetic rats. Increased lipoprotein lipase activity in livers of diabetic rats fed high dietary vitamin E. Diabetes 1986 Mar;35(3):278-81
Date
03/01/1986Pubmed ID
3512338DOI
10.2337/diab.35.3.278Scopus ID
2-s2.0-0022656207 (requires institutional sign-in at Scopus site) 49 CitationsAbstract
High vitamin E supplementation in the diets of streptozocin-induced diabetic rats eliminates accumulation of lipid peroxides in the plasma and the liver, returns the plasma triglycerides toward normal levels, and increases the activity of lipoprotein lipase. Vitamin E has no effect on the levels of insulin or glucose. These findings suggest that vitamin E increases the total hepatic triglyceride lipase activity by increasing the lipoprotein lipase activity possibly by protecting the membrane-bound lipase against peroxidative damage.
Author List
Pritchard KA Jr, Patel ST, Karpen CW, Newman HA, Panganamala RVAuthor
Kirkwood A. Pritchard PhD Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBlood Glucose
Diabetes Mellitus, Experimental
Insulin
Lipase
Lipid Peroxides
Lipoprotein Lipase
Liver
Male
Rats
Rats, Inbred Strains
Triglycerides
Vitamin E