Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation. Eur J Neurosci 2008 Jun;27(11):2821-9
Date
07/01/2008Pubmed ID
18588527Pubmed Central ID
PMC2593941DOI
10.1111/j.1460-9568.2008.06266.xScopus ID
2-s2.0-45149111341 (requires institutional sign-in at Scopus site) 136 CitationsAbstract
Daily life stressors are a major environmental factor contributing to precipitation and exacerbation of mental illness. Animal models using repeated homotypic stress induce anxious and depressive phenotypes and are used to study the pathophysiology of affective disorders. Here we discuss data demonstrating that repeated homotypic stress produces temporally and anatomically distinct changes in endocannabinoid signaling components within stress-responsive brain regions. We also present evidence describing the neural and behavioral correlates of these adaptations in endocannabinoid signaling. These data support a role for endocannabinoid signaling in the central nervous system response to chronic, homotypic stress, and specifically in the process of stress-response habituation. The clinical implications of these findings for the pathophysiology and treatment of affective disorders are discussed.
Author List
Patel S, Hillard CJAuthor
Cecilia J. Hillard PhD Associate Dean, Center Director, Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adaptation, PhysiologicalAnimals
Anxiety Disorders
Brain
Cannabinoid Receptor Modulators
Depressive Disorder
Disease Models, Animal
Endocannabinoids
Humans
Mood Disorders
Stress, Psychological
