Transvascular albumin and IgG flux in skin and skeletal muscle following plasmapheresis. Microvasc Res 1992 Nov;44(3):295-306
Date
11/01/1992Pubmed ID
1479930DOI
10.1016/0026-2862(92)90089-8Scopus ID
2-s2.0-0026460212 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
The extravascular uptake for labeled albumin and IgG and the extravascular masses for endogenous albumin and IgG were measured in skin and skeletal muscle from anesthetized rabbits following 24 hr of intermittent plasmapheresis. An amount of protein equivalent to the total intravascular protein mass was removed. There was a significant reduction in the extravascular mass for albumin in both tissues and for IgG in skin. The shift of albumin out of the extravascular space of skin and skeletal muscle could account for 95% of the vascular replacement of albumin. The extravascular uptake for the labeled proteins was measured as the 1-hr extravascular distribution space at plasma concentration divided by time and expressed as a plasma clearance. The plasma volume in the tissue samples was estimated from the 3-min distribution space for labeled transferrin. Following plasmapheresis the rate of extravascular uptake for both labeled proteins was greater than that for control or sham-operated animals, suggesting an increase in transvascular protein permeability. The transvascular fluxes for native albumin and IgG were not increased due to the decrease in the plasma concentrations. The results were consistent with the major mechanism for a shift of plasma proteins being due to a decrease in plasma protein concentration and a subsequent increase in lymph flow instead of a decrease in transvascular protein permeability.
Author List
Wallace JR, Powers MR, Bell DRMESH terms used to index this publication - Major topics in bold
AlbuminsAnimals
Biological Transport
Blood Proteins
Blood Volume
Capillary Permeability
Immunoglobulin G
Muscles
Plasmapheresis
Rabbits
Skin
Time Factors
