Faculty Collaboration Database

Neural control of the canine pylorus. Am J Surg 1979 Jan;137(1):92-8

Date

01/01/1979

Pubmed ID

758846

DOI

10.1016/0002-9610(79)90017-5

Scopus ID

2-s2.0-0018386631 (requires institutional sign-in at Scopus site)   16 Citations

Abstract

After atropine administration the anesthetized dog exhibits significant spontaneous pyloric contractile activity and an inhibition-relaxation response upon electrical vagal stimulation. This inhibition-relaxation response was completely blocked by tetrodotoxin administration and by transection of the intraabdominal vagal nerves. In addition, tetrodotoxin administration caused a dramatic increase in spontaneous pyloric motor activity. The histaminergic receptor antagonists diphenhydramine and cimetidine did not block the inhibition-relaxation response. The octapeptide of cholecystokinin (CCK-OP) caused a dose-dependent increase in antral and pyloric motor activity which was significantly decreased by atropine administration. Therefore, histamine and CCK do not appear to play a significant role in the vagally mediated inhibition-relaxation response of the canine pylorus or in the atropine-resistant spontaneous pyloric motor activity.

Author List

Telford GL, Mir SS, Mason GR, Ormsbee HS 3rd

MESH terms used to index this publication - Major topics in bold

Animals
Atropine
Autonomic Nerve Block
Cholecystokinin
Dogs
Duodenum
Electric Stimulation
Gastrointestinal Motility
Histamine
Muscle Contraction
Muscle, Smooth
Pyloric Antrum
Pylorus
Tetrodotoxin
Vagotomy
Vagus Nerve