OFFICE ADDRESS: |
Basic Science Building |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Dixon KJ, Siebert JR, Wang D, Abel AM, Johnson KE, Riese MJ, Terhune SS, Tarakanova VL, Thakar MS, Malarkannan S. MyD88 is an essential regulator of NK cell-mediated clearance of MCMV infection. Mol Immunol. 2021 Sep;137:94-104. |
2. Khalil M, Wang D, Hashemi E, Terhune SS, Malarkannan S. Implications of a 'Third Signal' in NK Cells. Cells. 2021 Jul 31;10(8). PMCID: PMC8393955 |
3. Jung Y, Kraikivski P, Shafiekhani S, Terhune SS, Dash RK. Crosstalk between Plk1, p53, cell cycle, and G2/M DNA damage checkpoint regulation in cancer: computational modeling and analysis. NPJ Syst Biol Appl. 2021 Dec 09;7(1):46. PMCID: PMC8660825 |
4. Dean HJ, Terhune SS, Shieh MT, Susmarski N, Spear PG. Single amino acid substitutions in gD of herpes simplex virus 1 confer resistance to gD-mediated interference and cause cell-type-dependent alterations in infectivity. Virology. 1994 Feb 15;199(1):67-80. |
5. Terhune SS, Coleman KT, Sekulovich R, Burke RL, Spear PG. Limited variability of glycoprotein gene sequences and neutralizing targets in herpes simplex virus type 2 isolates and stability on passage in cell culture. J Infect Dis. 1998 Jul;178(1):8-15. |
6. Thomas JT, Oh ST, Terhune SS, Laimins LA. Cellular changes induced by low-risk human papillomavirus type 11 in keratinocytes that stably maintain viral episomes. J Virol. 2001 Aug;75(16):7564-71. PMCID: PMC114991 |
7. Dean HJ, Warner MS, Terhune SS, Johnson RM, Spear PG. Viral determinants of the variable sensitivity of herpes simplex virus strains to gD-mediated interference. J Virol. 1995 Aug;69(8):5171-6. PMCID: PMC189341 |
8. Terhune SS, Milcarek C, Laimins LA. Regulation of human papillomavirus type 31 polyadenylation during the differentiation-dependent life cycle. J Virol. 1999 Sep;73(9):7185-92. PMCID: PMC104242 |
9. Terhune SS, Hubert WG, Thomas JT, Laimins LA. Early polyadenylation signals of human papillomavirus type 31 negatively regulate capsid gene expression. J Virol. 2001 Sep;75(17):8147-57. PMCID: PMC115059 |
10. Goodrum F, Jordan CT, Terhune SS, High K, Shenk T. Differential outcomes of human cytomegalovirus infection in primitive hematopoietic cell subpopulations. Blood. 2004 Aug 01;104(3):687-95. |
11. Terhune SS, Schröer J, Shenk T. RNAs are packaged into human cytomegalovirus virions in proportion to their intracellular concentration. J Virol. 2004 Oct;78(19):10390-8. PMCID: PMC516422 |
12. Terhune S, Torigoi E, Moorman N, Silva M, Qian Z, Shenk T, Yu D. Human cytomegalovirus UL38 protein blocks apoptosis. J Virol. 2007 Apr;81(7):3109-23. PMCID: PMC1866066 |
13. Moorman NJ, Cristea IM, Terhune SS, Rout MP, Chait BT, Shenk T. Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex. Cell Host Microbe. 2008 Apr 17;3(4):253-62. PMCID: PMC2759192 |
14. Mitchell DP, Savaryn JP, Moorman NJ, Shenk T, Terhune SS. Human cytomegalovirus UL28 and UL29 open reading frames encode a spliced mRNA and stimulate accumulation of immediate-early RNAs. J Virol. 2009 Oct;83(19):10187-97. PMCID: PMC2748044 |
15. Cristea IM, Moorman NJ, Terhune SS, Cuevas CD, O'Keefe ES, Rout MP, Chait BT, Shenk T. Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein. J Virol. 2010 Aug;84(15):7803-14. PMCID: PMC2897612 |
16. Terhune SS, Moorman NJ, Cristea IM, Savaryn JP, Cuevas-Bennett C, Rout MP, Chait BT, Shenk T. Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA. PLoS Pathog. 2010 Jun 24;6(6):e1000965. PMCID: PMC2891856 |
17. Reitsma JM, Savaryn JP, Faust K, Sato H, Halligan BD, Terhune SS. Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest. Cell Host Microbe. 2011 Feb 17;9(2):103-14. |
18. White MJ, Savaryn JP, Bretl DJ, He H, Penoske RM, Terhune SS, Zahrt TC. The HtrA-like serine protease PepD interacts with and modulates the Mycobacterium tuberculosis 35-kDa antigen outer envelope protein. PLoS One. 2011 Mar 22;6(3):e18175. PMCID: PMC3062566 |
19. Anderson DM, Schmalzer KM, Sato H, Casey M, Terhune SS, Haas AL, Feix JB, Frank DW. Ubiquitin and ubiquitin-modified proteins activate the Pseudomonas aeruginosa T3SS cytotoxin, ExoU. Mol Microbiol. 2011 Dec;82(6):1454-67. PMCID: PMC3237844 |
20. Fehr AR, Gualberto NC, Savaryn JP, Terhune SS, Yu D. Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a. PLoS Pathog. 2012;8(7):e1002789. PMCID: PMC3390409 |
21. Lam V, Bigley T, Terhune SS, Wakatsuki T. A method for quantifying mechanical properties of tissue following viral infection. PLoS One. 2012;7(8):e42197. PMCID: PMC3411685 |
22. Savaryn JP, Reitsma JM, Bigley TM, Halligan BD, Qian Z, Yu D, Terhune SS. Human cytomegalovirus pUL29/28 and pUL38 repression of p53-regulated p21CIP1 and caspase 1 promoters during infection. J Virol. 2013 Mar;87(5):2463-74. PMCID: PMC3571358 |
23. Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL. A conserved gammaherpesvirus protein kinase targets histone deacetylases 1 and 2 to facilitate viral replication in primary macrophages. J Virol. 2013 Jul;87(13):7314-25. PMCID: PMC3700300 |
24. Bigley TM, Reitsma JM, Mirza SP, Terhune SS. Human cytomegalovirus pUL97 regulates the viral major immediate early promoter by phosphorylation-mediated disruption of histone deacetylase 1 binding. J Virol. 2013 Jul;87(13):7393-408. PMCID: PMC3700266 |
25. Reitsma JM, Sato H, Nevels M, Terhune SS, Paulus C. Human cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequestering STAT3 in the nucleus. J Virol. 2013 Oct;87(19):10763-76. PMCID: PMC3807375 |
26. Rowles DL, Terhune SS, Cristea IM. Discovery of host-viral protein complexes during infection. Methods Mol Biol. 2013;1064:43-70. PMCID: PMC4162421 |
27. Reitsma JM, Terhune SS. Inhibition of cellular STAT3 synergizes with the cytomegalovirus kinase inhibitor maribavir to disrupt infection. Antiviral Res. 2013 Nov;100(2):321-7. PMCID: PMC3845884 |
28. Bretl DJ, Bigley TM, Terhune SS, Zahrt TC. The MprB extracytoplasmic domain negatively regulates activation of the Mycobacterium tuberculosis MprAB two-component system. J Bacteriol. 2014 Jan;196(2):391-406. PMCID: PMC3911260 |
29. Carter DM, Westdorp K, Noon KR, Terhune SS. Proteomic identification of nuclear processes manipulated by cytomegalovirus early during infection. Proteomics. 2015 Jun;15(12):1995-2005. PMCID: PMC4556115 |
30. Savaryn JP, Skinner OS, Fornelli L, Fellers RT, Compton PD, Terhune SS, Abecassis MM, Kelleher NL. Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry. J Proteomics. 2016 Feb 16;134:76-84. PMCID: PMC4633404 |
31. Bigley TM, Reitsma JM, Terhune SS. Antagonistic Relationship between Human Cytomegalovirus pUL27 and pUL97 Activities during Infection. J Virol. 2015 Oct;89(20):10230-46. PMCID: PMC4580190 |
32. Bigley TM, McGivern JV, Ebert AD, Terhune SS. Impact of a cytomegalovirus kinase inhibitor on infection and neuronal progenitor cell differentiation. Antiviral Res. 2016 May;129:67-73. PMCID: PMC4957402 |
33. Buehler J, Zeltzer S, Reitsma J, Petrucelli A, Umashankar M, Rak M, Zagallo P, Schroeder J, Terhune S, Goodrum F. Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication. PLoS Pathog. 2016 May;12(5):e1005655. PMCID: PMC4878804 |
34. Greseth MD, Carter DC, Terhune SS, Traktman P. Proteomic Screen for Cellular Targets of the Vaccinia Virus F10 Protein Kinase Reveals that Phosphorylation of mDia Regulates Stress Fiber Formation. Mol Cell Proteomics. 2017 Apr;16(4 suppl 1):S124-S143. PMCID: PMC5393388 |
35. Westdorp KN, Sand A, Moorman NJ, Terhune SS. Cytomegalovirus Late Protein pUL31 Alters Pre-rRNA Expression and Nuclear Organization during Infection. J Virol. 2017 Sep 15;91(18). PMCID: PMC5571270 |
36. Gonyo P, Bergom C, Brandt AC, Tsaih SW, Sun Y, Bigley TM, Lorimer EL, Terhune SS, Rui H, Flister MJ, Long RM, Williams CL. SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression. Oncogene. 2017 Dec 14;36(50):6873-6883. PMCID: PMC5730474 |
37. Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL. Correction for Mounce et al., "A Conserved Gammaherpesvirus Protein Kinase Targets Histone Deacetylases 1 and 2 To Facilitate Viral Replication in Primary Macrophages". J Virol. 2018 Jan 01;92(1). PMCID: PMC5730793 |
38. Westdorp KN, Terhune SS. Impact of RNA polymerase I inhibitor CX-5461 on viral kinase-dependent and -independent cytomegalovirus replication. Antiviral Res. 2018 May;153:33-38. PMCID: PMC6015744 |
39. Armstrong RM, Carter DC, Atkinson SN, Terhune SS, Zahrt TC. Association of Mycobacterium Proteins with Lipid Droplets. J Bacteriol. 2018 Aug 15;200(16). PMCID: PMC6060360 |
40. Kriegel AJ, Terhune SS, Greene AS, Noon KR, Pereckas MS, Liang M. Isomer-specific effect of microRNA miR-29b on nuclear morphology. J Biol Chem. 2018 Sep 07;293(36):14080-14088. PMCID: PMC6130969 |
41. Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F. Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency. J Virol. 2018 Oct 15;92(20). PMCID: PMC6158428 |
42. Forte E, Swaminathan S, Schroeder MW, Kim JY, Terhune SS, Hummel M. Tumor Necrosis Factor Alpha Induces Reactivation of Human Cytomegalovirus Independently of Myeloid Cell Differentiation following Posttranscriptional Establishment of Latency. mBio. 2018 Sep 11;9(5). PMCID: PMC6134100 |
43. Sison SL, O'Brien BS, Johnson AJ, Seminary ER, Terhune SS, Ebert AD. Human Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids. J Virol. 2019 Sep 01;93(17). PMCID: PMC6694809 |
44. Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F. Erratum for Rak et al., "Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency". J Virol. 2020 Mar 17;94(7). PMCID: PMC7081901 |
45. Terhune SS, Jung Y, Cataldo KM, Dash RK. Network mechanisms and dysfunction within an integrated computational model of progression through mitosis in the human cell cycle. PLoS Comput Biol. 2020 Apr;16(4):e1007733. PMCID: PMC7162553 |
46. Mokry RL, Schumacher ML, Hogg N, Terhune SS. Nitric oxide circumvents virus-mediated metabolic regulation during human cytomegalovirus infection mBio. November-December 2020;11(6):1-25. |
47. Maranto C, Udhane V, Jia J, Verma R, Müller-Newen G, LaViolette PS, Pereckas M, Sabharwal L, Terhune S, Pattabiraman N, Njar VCO, Imig JD, Wang L, Nevalainen MT. Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo. Cancers (Basel). 2020 Nov 18;12(11). PMCID: PMC7724566 |
48. Mokry RL, Schumacher ML, Hogg N, Terhune SS. Nitric Oxide Circumvents Virus-Mediated Metabolic Regulation during Human Cytomegalovirus Infection. mBio. 2020 Dec 15;11(6). PMCID: PMC7773989 |
49. O'Brien BS, Mokry RL, Schumacher ML, Pulakanti K, Rao S, Terhune SS, Ebert AD. Downregulation of neurodevelopmental gene expression in iPSC-derived cerebral organoids upon infection by human cytomegalovirus iScience. 15 April 2022;25(4). |
50. Khalil M, Mei A, Hashemi E, Wang D, Schumacher M, Terhune S, Malarkannan S. Method to Study Adaptive NK Cells Following MCMV Infections. Methods Mol Biol. 2022;2463:195-204. |
51. Albright ER, Morrison K, Ranganathan P, Carter DM, Nishikiori M, Lee JH, Slayton MD, Ahlquist P, Terhune SS, Kalejta RF. Human cytomegalovirus lytic infection inhibits replication-dependent histone synthesis and requires stem loop binding protein function. Proc Natl Acad Sci U S A. 2022 Apr 05;119(14):e2122174119. PMCID: PMC9169081 |
52. O'Brien BS, Mokry RL, Schumacher ML, Pulakanti K, Rao S, Terhune SS, Ebert AD. Downregulation of neurodevelopmental gene expression in iPSC-derived cerebral organoids upon infection by human cytomegalovirus. iScience. 2022 Apr 15;25(4):104098. PMCID: PMC8980761 |
53. Monti CE, Mokry RL, Schumacher ML, Dash RK, Terhune SS. Computational modeling of protracted HCMV replication using genome substrates and protein temporal profiles. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2201787119. PMCID: PMC9437303 |
54. Mokry RL, O'Brien BS, Adelman JW, Rosas S, Schumacher ML, Ebert AD, Terhune SS. Nitric Oxide Attenuates Human Cytomegalovirus Infection yet Disrupts Neural Cell Differentiation and Tissue Organization. J Virol. 2022 Jul 27;96(14):e0012622. PMCID: PMC9327702 |
55. Forte E, Li M, Ayaloglu Butun F, Hu Q, Borst EM, Schipma MJ, Piunti A, Shilatifard A, Terhune SS, Abecassis M, Meier JL, Hummel M. Critical Role for the Human Cytomegalovirus Major Immediate Early Proteins in Recruitment of RNA Polymerase II and H3K27Ac To an Enhancer-Like Element in Ori<i>Lyt</i>. Microbiol Spectr. 2023 Feb 14;11(1):e0314422. PMCID: PMC9927211 |
56. Zarrella K, Longmire P, Zeltzer S, Collins-McMillen D, Hancock M, Buehler J, Reitsma JM, Terhune SS, Nelson JA, Goodrum F. Human cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection. PLoS Pathog. 2023 Jun;19(6):e1011185. PMCID: PMC10284425 |
57. Adelman JW, Rosas-Rogers S, Schumacher ML, Mokry RL, Terhune SS, Ebert AD. Human Cytomegalovirus Induces Significant Structural and Functional Changes in Terminally Differentiated Human Cortical Neurons. bioRxiv. 2023 Mar 06. PMCID: PMC10028818 |
58. Zarrella K, Longmire P, Zeltzer S, Collins-McMillen D, Hancock M, Buehler J, Reitsma JM, Terhune SS, Nelson JA, Goodrum F. Human Cytomegalovirus UL138 Interaction with USP1 Activates STAT1 in infection. bioRxiv. 2023 Feb 07. PMCID: PMC9934528 |
59. Shah V, Womack J, Zamora AE, Terhune SS, Dash RK. Simulating the Evolution of Signaling Signatures during CART-Cell - Tumor Cell Interactions. ArXiv. 2023 Feb 08. PMCID: PMC9934731 |
60. Adelman JW, Rosas-Rogers S, Schumacher ML, Mokry RL, Terhune SS, Ebert AD. Human cytomegalovirus induces significant structural and functional changes in terminally differentiated human cortical neurons. mBio. 2023 Nov 15;14(6):e0225123. PMCID: PMC10746155 |
61. O'Brien BS, Mokry RL, Schumacher ML, Rosas-Rogers S, Terhune SS, Ebert AD. Neutralizing antibodies with neurotropic factor treatment maintain neurodevelopmental gene expression upon exposure to human cytomegalovirus. J Virol. 2023 Oct 31;97(10):e0069623. PMCID: PMC10653813 |