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CURRICULUM VITAE

Adeleye James Afolayan MD
Associate Professor
Department of Pediatrics
Division of Neonatology

OFFICE ADDRESS:
Children's Corporate Center
999 N 92 St
Milwaukee, WI 53226

EDUCATION:
1991 - 1997 M.B, B.S, (Medicine and Surgery), College of Health Sciences, University of Ilorin, Ilorin, Nigeria
2006 - 2009 Residency in Pediatrics, Albert Einstein College of Medicine,, Bronx-Lebanon Hospital Program, Bronx, NY

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
1998 - 1999 Internship, College of Health Sciences, University of Ilorin, Nigeria
2006 - 2008 Internship, Dept of Pediatrics, Program Director, Ayoade Adeniyi, MD., Bronx-Lebanon Hospital Center, Bronx, NY
2008 - 2009 Chief Resident, Bronx-Lebanon Hospital Program, Bronx, NY
2009 - 2012 Fellowship, Pediatrics, Neonatal-Perinatal Medicine, Children's Wisconsin and Medical College of Wisconsin, Milwaukee, WI
2011 - 2012 Chief Fellow, Neonatal-Perinatal Medicine Program, Pediatrics, Neonatology, Medical College of Wisconsin, Milwaukee, WI
2014 Grant writing course, CTSI, Medical College of WI, Milwaukee, WI 53226
2018 Mouse Genetics, IDP, Medical College of Wisconsin, Milwaukee, WI 53226

FACULTY APPOINTMENTS:
1999 - 2005 Medical Officer, Pediatrics, Karl Heuser Hospital, Belize City, Belize. Central America
2012 - Present Assistant Professor, Pediatrics, Neonatology, Medical College of Wisconsin, Milwaukee, WI 53226

HOSPITAL STAFF PRIVILEGES:
2010 - 2015 Neonatologist, Pediatrics, Neonatology, Summit Aurora Hospital, Grafton, WI
2012 - 2017 Neonatologist, Pediatrics, Neonatology, Community Memorial Hospital, Menomonee Falls, WI
2012 - 2016 Neonatologist, Pediatrics, Neonatology, St. Joseph Hospital, West Bend, WI
2012 - 2017 Neonatologist, Pediatrics, Neonatology, Oconomowoc Memorial Hospital, Oconomowoc, WI
2015 - 2016 Neonatologist, Pediatrics, Neonatology, ThedaCare Hospital, Appleton, WI
2018 - 2019 Neonatologist, Pediatrics, Neonatology, All Saints Hospital, Racine, WI

AWARDS AND HONORS:
2009 Best Research Resident, Department of Pediatrics, Bronx-Lebanon Hospital Program
2009 Best Resident, Department of Pediatrics , Bronx-Lebanon Hospital
2011 Young Investigators Travel award , Pediatric Academic Society
2012 Young Investigators Travel award , Pediatric Academic Society
2012 Young Investigator Award , Society for Pediatric Research, NIH
2012 Fellows’ Research Award, Medical College of Wisconsin
2014 Young Investigator Award, Lung Biology Research, Chicago, IL
2014 Young Investigator Award , Perinatal Research, NICHD, Chicago, IL

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
1999 - 2002 Nigerian Medical Association
2002 - 2016 Belize Medical Association
2006 - Present American Academy of Pediatrics
2009 - 2012 American Medical Association
2016 - Present Society for Pediatric Research
2018 - Present American Society for Experimental Biology (ASMB)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Journal Review
2014 - Present International Journal of Molecular and Cell Biology, Pediatrics, International Journal of Molecular Science,PLOS one,SRL Cardiology,Journal of innovative Optical Science,Journal of Molecular Biology

LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
2013 - 2016 Member, Resident Selection Committee,, Children Hospital of Wisconsin, Milwaukee
2017 - Present Poster Reviewer, Graduate Students, Experimental Biology
2017 - Present Grant Reviewer, CRI Pilot Grant Review Committee
2017 - Present Research Award Selection Committee, Department of Pediatric (DOP)
2018 - Present Poster/Abstract Reviewer,, Medical Student Summer Program, MCW

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
2017 - Present Member, AHA study section, cell and vascular biology

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
AKT-mediated phosphorylation of hsp70 regulates the mitochondrial import of SOD2 and oxidative stress in vascular cells.
Source:
NIH/NHLBI
PI:
James Afolayan
Dates:
2016 - 2020
Direct Funds:
$780,000 (K08)
 
Non-Peer Review
Title:
AKT-mediated phosphorylation of hsp70 regulates the mitochondrial import of SOD2 and oxidative stress in vascular cells
Source:
CRI
PI:
James Afolayan
Dates:
2016 - 2020
Direct Funds:
$50,000 (K08)
 
Title:
Mechanisms of impaired angiogenesis in neonatal pulmonary hypertension
Role:
Co-PI
PI:
Ganesh Konduri
Dates:
01/2018 - 12/2019
Direct Funds:
$125,000 (CRI)
 
Pending
Peer Review
Title:
Proteostatic Dysregulation of mitochondrial superoxide dismutase (SOD2): A Novel Mechanism and Therapeutic Target in PPHN
Source:
NIH/NHLBI
PI:
James Afolayan
Dates:
2020 - Present
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
The Clinical and Translational Science Institute Research (CTSI) in Progress Seminar, 05/2017
Down regulation of manganese superoxide dismutase (MnSOD) activity and expression contribute to endothelial dysfunction in persistent pulmonary hypertension of the newborn., Grand Round Presentation, Medical College of Wisconsin
 
National
C-terminal phosphorylation of Hsp70 controls alternate binding of OLA1 and CHIP to control mitochondrial redox signaling in vascular cells., Vasculata conference, 2019
 

ABSTRACTS BY INVITATIONS:
Afolayan JA, Davis JM, Eis A, Teng RJ, Konduri GG. Down regulation of manganese superoxide dismutase (MnSOD) activity and expression contribute to endothelial dysfunction in persistent pulmonary hypertension of the newborn (PPHN). SPR 2011 Platform presentation
Adeleye Afolayan, Ayoade Adeniyi, Ronald Bainbridge, Richard Neugebauer. Residents finance, how do physicians in training measures up? Mead Johnson research symposium -2009 (platform presentation) ESPR, Baltimore, Poster presentation-2009 (platform presentation)
Adeleye Afolayan, Cesar Mella, Zarlasht Manzoor, Cynthia Lewis, Ayoade Adeniyi, Ronald Bainbridge, Richard Neugebauer. Internet Usage to Obtain Health Information among Adolescents in an Urban Healthcare Network. Easter SPR 2008 oral presentation and PAS Hawaii-2008 (Poster presentation)
Afolayan JA, Davis JM, Eis A, Teng RJ, Konduri GG. Down regulation of manganese superoxide dismutase (MnSOD) activity and expression contribute to endothelial dysfunction in persistent pulmonary hypertension of the newborn (PPHN). SPR 2011 Platform presentation
Afolayan JA, Eis A, Bakhutashivili I, Teng RJ, Konduri GG. Inducible Heat shock Protein 70 (Hsp70) Regulates Manganese Superoxide Dismutase (MnSOD) Activity and Mitochondrial Oxidative Stress in Persistent Pulmonary Hypertension of the Newborn (PPHN). SPR 2012
Girija Konduri, Ivane Bakhutashvili, Annie Eis, and Adeleye Afolayan. Antenatal Betamethasone Improves Postnatal Transition in Late Preterm Lambs with Persistent Pulmonary Hypertension of the Newborn. Poster presentation SPR, 2011

BOOK CHAPTERS AND REVIEWS:
Megha Sharma, Adeleye J. Afolayan. Redox Signaling in Neonatal lungs (under review)
Afolayan JA, Konduri GG. Persistent Pulmonary Hypertension of the Newborn: Pathophysiology and Management. In: Rao PS, Vidyasagar D, eds. Perinatal Cardiology: A Multidisciplinary Approach. Minneapolis, MN: Cardiotext Publishing; 2015.

PATENTS:
GERAMT peptide-a selective inhibitor of SOD2-Declined

PLATFORM PRESENTATION:
Afolayan AJ, Zemanovic S, Teng RJ, and Konduri GG. Glutamic acid 446 and Arginine 447 in heat shock protein 70 (hsp70) are critical for regulating superoxide dismutase-2 (SOD2) function (poster presentation). EB poster presentation
Mahajan C, Teng RJ, Eis A, Afolayan AJ, Konduri GG. Decreased Prostacyclin Synthase (PGIS) Expression and Activity and Post-Translational Modifications in Persistent Pulmonary Hypertension of the Newborn (PPHN). SPR 2012 Poster Presentation
Makker K, Teng R-J, Afolayan AJ, Konduri GG. Increased hypoxia inducible factor-1α (HIF-1α) signaling is associated with oxidative stress in pulmonary artery endothelial cell (PAEC) from fetal lambs with persistent pulmonary hypertension (PPHN). SPR 2013 Poster Presentation.
Teng R-J, Cai S, Eis A, Afolayan AJ, Konduri GG. GTP-cyclohydrolase-1 (GCH1) modulates pulmonary artery endothelial cells’ (PAEC) mitochondrial function. 2015 SPR Poster Presentation
Alexander M, Konduri GG, Afolayan AJ. A Superoxide Dismutase-2 (SOD2) Binding Domain in Inducible Heat Shock Protein 70 Regulates Mitochondrial Oxidative Stress in the Pulmonary Artery Endothelium. 2016 SPR Poster Presentation.
Adam Schultz, Ganesh Konduri, Kirkwood Prichard, and Adeleye James Afolayan. The Evolutionarily Conserved Obg-like ATPase-1 (OLA1) Acts as a Molecular Chaperone to Regulate Cellular Stress Responses, Biochemistry and Molecular Biology, 2019
Afolayan AJ, Teng R-J, Konduri GG. Mitochondrial Targeting of eNOS regulates mitochondrial biogenesis in vascular cells. Platform presentation, Young investigator Biology conference, 2014
Afolayan AJ, Michalkiewicz T, Teng RJ, Zemanovic S, and Konduri GG. Increased mitochondrial superoxide levels leads to the development of neonatal pulmonary hypertension (PPHN). PAS, poster presentation
Afolayan AJ, Eis A, Mickalkiewicz T, Teng R-J, Konduri GG. Decreased NO availability contributes to impaired mitochondrial biogenesis and oxidative stress in fetal lambs with persistent pulmonary hypertension. 2015 EB Symposium Poster Presentation
Konduri GG. Michalkiewicz T, Afolayan AJ, Sampath V, Broeckel U, Kazzi N, Simpson P, Teng R-J. A variant in mitochondrial manganese superoxide dismutase (SOD2) associates with risk of bronchopulmonary dysplasia (BPD) in prematurely born African American infants. 2015 SPR Poster Presentation
Konduri GG, Callan E, Afolayan AJ, Teng R-J. Decreased PGC-1α-SIRT1 signaling leads to impaired angiogenesis in persistent pulmonary hypertension of the newborn (PPHN). 2015 EB Symposium Poster Presentation
Adam Schultz, Ganesh Konduri, and Adeleye James Afolayan. Decreased OLA1 expression: A Novel Mechanism for Posttranslational Downregulation of SOD2 in PPHN, PAS2019
Afolayan AJ, Teng R-J, Konduri GG. Decreased NO availability contributes to impaired mitochondrial biogenesis and oxidative stress in fetal lambs with persistent pulmonary hypertension. 2015 SPR Platform Presentation


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Afolayan AJ, Eis A, Teng R-J, Bakhutashvili I, Kaul S, Davis JM, Konduri GG. Downregulation of manganese superoxide dismutase activity and expression contributes to oxidative stress in persistent pulmonary hypertension of the newborn. Am J Physiol Lung Cell Mol Physiol 2012; 303: L870-L879.
2. Teng R-J, Du J, Afolayan AJ, Eis A, Shi Y, Konduri GG. AMP kinase activation improves angiogenesis in pulmonary artery endothelial cells within utero pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 2013; 304: L29-L42.
3. Afolayan AJ, Teng R-J, Eis A, Rana U, Broniowska KA, Corbett JA, Pritchard KA, Konduri GG. Inducible HSP70 regulates superoxide dismutase-2 and mitochondrial oxidative stress in the endothelial cells from developing lungs. Am J Physiol Lung Cell Mol Physiol 2014; 306: L351-L360.
4. Teng R-J, Rana U, Afolayan AJ, Zhao B, Miao QR, Konduri GG. Nogo-B receptor modulates angiogenesis response of pulmonary artery endothelial cells through eNOS coupling. Am J Respir Cell Mol Biol. 2014; 51:169-177.
5. Mahajan CN, Afolayan AJ, Eis A, Teng R-J, Konduri GG. Altered prostanoid metabolism contributes to impaired angiogenesis in persistent pulmonary hypertension in a fetal lamb model. Pediatr Res 2015; 77:455-462.
6. Konduri GG, Afolayan AJ, Eis A, Pritchard K, Teng R-J. Interaction of endothelial nitric oxide synthase with mitochondria regulates oxidative stress and function in fetal pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 2015; 309: L1009-17. PMID: 26320159
7. Teng R-J, Wu T-J, Afolayan AJ, Konduri GG. Nitrotyrosine impairs mitochondrial function in fetal lamb pulmonary artery endothelial cells. Am J Physiol Cell Physiol 2016; 310:C80-88.
8. Afolayan AJ, Eis A, Michalkiewicz T, Teng R-J, Lakshminrusimha S, Konduri GG. Decreased endothelial NOS expression and function contributes to impaired mitochondrial biogenesis and oxidative stress in fetal lambs with PPHN. Am J Physiol Lung Cell Mol Physiol 2016; 310: L40-49.
9. Konduri GG, Bakhutashvili I, Eis A, Afolayan A. Antenatal betamethasone improves postnatal transition in late preterm lambs with persistent pulmonary hypertension of the newborn. Pediatr Res. 2013 May; 73(5):621-9. Doi: 10.1038/pr.2013.20.
10. Adeleye J. Afolayan, Maxwell Alexander, Rebecca Holmes, Daisy Sahoo, Ru-Jeng Teng, Teresa Mick, Kirkwood Pritchard Jr., Girija G. Konduri. Domain Mapping of Heat Shock Protein 70 reveals that Glutamic acid 446 and Arginine 447 are Critical for Regulating Superoxide Dismutase-2 Function. J Biol Chem. 2017 Feb 10; 292(6):2369-2378. doi: 10.1074/jbc.M116.756122
11. Ru-Jeng Teng, Xigang Jing, Teresa Michalkiewicz, Adeleye Afolayan, Tzong-Jin Wu, and Girija Konduri. Attenuation of Endoplasmic Reticulum Stress by Caffeine Ameliorates Hyperoxia-Induced Lung Injury. Am J Physiol Lung Cell Mol Physiol. 2017 Feb 17: ajplung.00405.2016. doi: 10.1152/ajplung.00405.2016
12. Loomba RS, Bhushan A, Afolayan AJ. A pilot study exploring the impact of cardiac medications on ciliary beat frequency: possible implications for clinical management. J Basic Clin Physiol Pharmacol. 2018 Sep 25;29 (5):565-571. Doi: 10.1515/jbcpp-2017-0130.
13. Zemanovic S, Ivanov MV, Ivanova LV, Bhatnagar A, Michalkiewicz T, Teng RJ, Kumar S, Rathore R, Pritchard KA Jr, Konduri GG, Afolayan AJ. Dynamic Phosphorylation of the C Terminus of Hsp70 Regulates the Mitochondrial Import of SOD2 and Redox Balance. Cell Rep. 2018 Nov 27; 25 (9):2605-2616.e7. Doi: 10.1016/j.celrep.2018.11.015.
14. K Makker K1, Afolayan AJ, Teng RJ, Konduri GG. Altered hypoxia-inducible factor-1α (HIF-1α) signaling contributes to impaired angiogenesis in fetal lambs with persistent pulmonary hypertension of the newborn (PPHN). Physiol Rep. 2019 Feb;7(3): e13986. doi: 10.14814/phy2.13986.
15. Adam Schultz, Olubunmi Olorundami, Ru-Jeng Teng, Jason Jarzembowski, Zheng-Zheng Shi, Suresh Kumar, Kirkwood Pritchard, Jr., Girija Konduri, and Adeleye Afolayan. Decreased OLA1 Expression Drives Ubiquitin-Proteasome Signaling to Downregulate Mitochondrial Superoxide Dismutase (SOD2) in Persistent Pulmonary Hypertension of the newborn. Hypertension. 2019 Oct;74(4):957-966. doi: 10.1161 /HYPERTENSION AHA.119.13430. Epub 2019 Sep 3
 

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