CURRICULUM VITAE
Alan Bloom PhD, MA
Alan Bloom PhD, MA
Emeritus Professor
Department of Pharmacology and Toxicology
Department of Pharmacology and Toxicology
OFFICE ADDRESS: |
8701 Watertown Plank Road |
Milwaukee, WI 53226 |
EDUCATION: |
1969 BA - Psychology, State University of New York, Buffalo, NY |
1973 MA - Neuropsychopharmacology, University of Louisville, Louisville, KY |
1974 - 1975 NIDA Postdoctoral Traineeship, Department of Pharmacology, Medical College of Virginia, Richmond, VA |
1974 PhD - Neuropsychopharmacology, University of Louisville, Louisville, KY |
1975 - 1976 NIDA Individual Postdoctoral Fellowship, Department of Pharmacology, Medical of Virginia, Richmond, VA |
FACULTY APPOINTMENTS: |
1976 - 1980 Assistant Professor, Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI |
1981 - 1987 Associate Professor, Pharmacology, Medical College of Wisconsin, Milwaukee, WI |
1988 - Present Professor, Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
International Brain Research Organization (Member ) |
Sigma Xi (Member) |
International Society for Magnetic Resonance in Medicine (Member) |
Organization for Human Brain Mapping (Member ) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorial Board |
1988 - 1991 Journal of Pharmacology and Experimental Therapeutics |
Journal Review |
Peptides |
Life Sciences |
Pesticide, Biochemistry and Physiology |
Chemico-Biological Interactions |
Molecular Pharmacology |
Proceedings of the Society for Experimental Biology and Medicine |
Journal of Pharmacology and Experimental Therapeutic |
Brain Research |
Biochemical Pharmacology |
Neuroscience letters |
Brain Research Bulletin |
Psychopharmacology |
Alcohol and Drug Research |
Physiology and Behavior |
Journal of Clinical Psychiatry |
Human Brain Mapping |
Anesthesiology |
Archives of General Psychiatry |
Pharmacology, Biochemistry and Behavior |
Neuroscience and Biobehavioral Reviews |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
1983 - 1992 Member, Non-Medical Use of Drugs, ASPET |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
International Cannabis Symposium, Oxford, England, 1984 |
Invited Speaker, International fMRI Training course, 2000 |
Invited Speaker, International fMRI Training course, 2002 |
National |
Marijuana '82 Symposium, Louisville, KY, 1982 |
Invited Speaker, American Quality Control Society, 1983 |
ASPET Marihuana Symposium, Boston, MA, 1985 |
Invited Speaker, MCMC Radiology, 1986 |
Invited Speaker, College for Seniors, 1986 |
Chairman, Dependence Potential, Washington, DC, 1987 |
Invited Speaker, MCMC Radiology, 1988 |
Invited Speaker, Medical College of Virginia, 1988 |
ASPET Cannabinoid Symposium, Salt Lake City, UT, 1989 |
International Cannabinoid Study Group, Richmond, 1989 |
Invited Speaker, Winter Refresher Course for Family Physicians, 1990 |
International Cannabinoid Study Group, Richmond, 1990 |
Visiting Professor, University of Illinois College of Medicine at Rockford, 1990 |
Invited Speaker, National Board of Medical Examiners, 1994 |
Invited Speaker, Carroll College, 1996 |
Representative, U.S. Pharmacopeia Convention, 2000 |
Invited Speaker, Brookhaven National Laboratories, 2003 |
American Psychiatric Association, New York, NY, 2004 |
FASEB Symposium on Testing Drugs for Abuse Liability and Physical |
Regional |
Invited speaker, University of Minnesota, 1981 |
Invited speaker, Chicago Medical School, 1982 |
Local |
Visiting Lecturer, Marquette University Dental School, Milwaukee, WI, 1979 |
Invited speaker, University of Wisconsin-Parkside, 1981 |
Invited speaker, Racine County Medical Society, 1982 |
Invited Speaker, St. Clare Hospital-Baraboo, 1983 |
Invited Speaker, American Statistical Association, Milwaukee Chapter, 1983 |
Invited Speaker, St. Michaels Hospital, 1983 |
Invited Speaker, University of Wisconsin-Oshkosh, 1984 |
Consultant, Public Defenders Office, 1985 |
Legal Consultant, 1985 - Present |
Invited Speaker, Carroll College, 1987 |
Visiting Professor, University of Wisconsin, Dept of Pharmacology, 1988 |
Scholarly Reviews of Academic Software Project, EDUCOM, 1988 - Present |
Alcohol and Other Drug Abuse Research Advisory Committee, State of Wisconsin, 1989 - Present |
Chairman, Drugs of Abuse and the Workplace Symposium, Milwaukee, WI, 1990 |
Visiting Professor, Marquette University, Milwaukee, WI, 1991 |
National Institute on Drug Abuse, Special Emphasis Panel, 1999 |
Consultant, Public Defenders Office, 2000 |
Representative, USP, Medical College of Wisconsin, 2000 |
Grant reviewer, Burroughs-Welcome Fund, 2000 |
Visiting Professor, Marquette University, Milwaukee. WI, 2001 |
Special Emphasis Panel, National Institute on Drug Abuse, 2002 |
Special Emphasis Panel, National Institute on Drug Abuse, 2003 |
International League Against Epilepsy, Milwaukee, WI, 2003 |
Special Emphasis Panel, National Institute on Drug Abuse, 2004 |
Invited Speaker, Marquette University, 2005 |
Special Emphasis Panel, National Institute on Drug Abuse, 2005 |
Grant Reviewer, Philip Morris External, 2005 |
Visiting Professor, Marquette University, Milwaukee, WI, 2006 |
Special Emphasis Panel, National Institute on Drug Abuse, 2006 |
Invited Speaker, Abbott Laboratories, 2006 |
Invited Speaker, Marquette University, 2007 |
Special Emphasis Panel, National Institute on Drug Abuse, 2007 |
Invited Speaker, University of Hawaii School of Medicine, 2008 - 2010 |
Centers Review Panel, National Institute on Drug Abuse, 2009 |
Invited Speaker, Marquette University, 2010 |
Centers Review Panel, National Institute on Drug Abuse, 2010 |
Centers Review Panel, National Institute on Drug Abuse, 2011 |
State of Wisconsin Controlled Substances Board, 2011 - Present |
Grant Reviewer, NSF |
Grant Reviewer, March of Dimes |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
1977 - 1983 Member, Computer Committee, Medical College of Wisconsin |
1978 - 1985 Chairman, Graduate Committee, Department of Pharmacology, Medical College of Wisconsin |
1978 - 1983 Member, Radiation Safety Committee, Medical College of Wisconsin |
1978 - 1985 Member, Graduate Studies Council, Medical College of Wisconsin |
1982 - 1983 Member, Library Director Search Committee, Medical College of Wisconsin |
1982 - 1983 Member, Psychiatry Intramural Review, Medical College of Wisconsin |
1983 - 1986 Member, Library Committee, Medical College of Wisconsin |
1983 - 1986 Member, Institutional Research Committee, Medical College of Wisconsin |
1983 - 1986 Member, Psychiatry Chairperson Search Committee, Medical College of Wisconsin |
1984 - 1985 Member, Programs Committee, Medical College of Wisconsin |
1985 Member, Biochemistry Intramural Review Committee, Medical College of Wisconsin |
1985 Chairman, Scientific and Academic Computer Review Committee, Medical College of Wisconsin |
1986 - 1988 Member, Neuroscience Search Committee, Medical College of Wisconsin |
1986 - 1992 Member, Faculty Welfare Committee, Medical College of Wisconsin |
1986 - 1993 Chairman, Scientific and Academic Computing Advisory Committee, Medical College of Wisconsin |
1987 Member, Radiology Review Committee, Medical College of Wisconsin |
1987 - 1993 Member, Strategic Research Planning Committee, Medical College of Wisconsin |
1987 - 1990 m, Academic Standing Committee, Medical College of Wisconsin |
1988 - 1989 Chairman, Faculty Welfare Committee, Medical College of Wisconsin |
1990 - 1992 Member, PET Steering Committee, Medical College of Wisconsin |
1992 - 1999 Member, Curriculum and Evaluation Committee, Medical College of Wisconsin |
1992 - 1998 Member, Graduate Studies Council, Medical College of Wisconsin |
1992 - 1994 Chairman, Evaluation Subcommittee, Medical College of Wisconsin |
1993 - 1996 Member, Steering Committee, Integrated Advanced Information Management System Project, Medical College of Wisconsin |
1994 - 1996 Chairman, Graduate School Curriculum and Programs Committee, Medical College of Wisconsin |
1996 - 1999 Chairman, M3-M4 Subcommittee, Medical College of Wisconsin |
1998 - 2004 m, Faculty Council, Medical College of Wisconsin |
1998 - 2004 Member, Nominating Committee, Medical College of Wisconsin |
2000 Member, Medical School Admissions Committee, Medical College of Wisconsin |
2000 - 2004 Chairman, Nominating Committee, Medical College of Wisconsin |
2000 - Present Member, FMLH Institutional Review Board #1, Medical College of Wisconsin |
2001 Member, Psychiatry Chairperson Search Committee, Medical College of Wisconsin |
2002 Member, Computer Committee, Medical College of Wisconsin |
2003 - Present Member, Functional Imaging Research Center Scientific Advisory Board, Functional Imaging Research Center |
2005 - 2008 Member, Faculty Benefits Committee, Medical College of Wisconsin |
2006 - 2009 Member, Academic Standing Committee, Medical College of Wisconsin |
2007 - Present Member, MRI Safety Committee, Medical College of Wisconsin |
2008 - Present Member, Translational Research Unit (TRU) Scientific Review Committee, Medical College of Wisconsin |
2008 - Present Member, MRI Safety Committee, Medical College of Wisconsin |
MCW TEACHING ACTIVITIES: |
Medical Student Education |
1989 Lecturer - Division of Child Psychiatry |
1990 Drug Abuse Pharmacology |
1991 Organizing Committee - Integrated Medical Neurosciences Course |
1992 - 1995 Steering Committee - Integrated Medical Neurosciences Course |
1992 - 2003 Course Director Medical Pharmacology |
1994 Lecturer - Preparation for Internship |
1996 Principals of Drug Action |
1997 - 2000 Lecturer – Ambulatory Clerkship |
1998 Principals of Drug Action |
2000 - 2003 Lecturer – Internal Medicine |
2003 - Present Seminar Director |
Graduate Student Education |
1977 - Present Lectures in Medical Pharmacology Course |
1978 CNS Pharmacology |
1979 - 1980 Lectures in Graduate Pharmacology |
1980 - 1986 Director, Pharmacology Graduate Program |
1981 Lectures in Graduate Pharmacology |
1982 Lectures in Graduate Pharmacology |
1983 Lectures in Graduate Pharmacology |
1983 CNS Pharmacology |
1984 Nursing Pharmacology |
1984 Lectures in Graduate Pharmacology |
1985 Lectures in Graduate Pharmacology |
1986 - 1990 Seminar Director |
1986 Lectures in Graduate Pharmacology |
1988 Lectures in Graduate Pharmacology |
1989 Lectures in Graduate Pharmacology |
1990 Lectures in Graduate Pharmacology |
1991 - 2000 Neurobehavioral Science Course |
1994 - 2006 Lectures in Graduate Pharmacology |
1996 - 1999 Seminar Director |
Course Director - Graduate Courses |
Resident and Fellow Education |
1988 Toxicology Grand Rounds |
1995 Toxicology Grand Rounds |
2001 Pediatrics Grand Rounds |
2003 Pediatrics Grand Rounds |
2006 Journal Club |
EXTRAMURAL TEACHING: |
Medical Student Education |
1996 - 1999 Marquette University, Nursing Pharmacology |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Graduate Students |
MS Students Advised |
1982 Christina G. Staatz, Medical College of Wisconsin |
1989 Leslie Sutherland, Medical College of Wisconsin |
PhD Students Advised |
1983 Cecilia J. Hillard, Medical College of Wisconsin |
PhD Committees |
Zhengxiong Xi, Medical College of Wisconsin |
Peter Kufahl, Medical College of Wisconsin |
Xiping Liu, Medical College of Wisconsin |
Sandra Roerig, Medical College of Wisconsin |
James Zhang, Medical College of Wisconsin |
Jun Xie, Medical College of Wisconsin |
Shelly Amen, Medical College of Wisconsin |
Christopher Roberts, Medical College of Wisconsin |
Yu Xu, Medical College of Wisconsin |
Fong Luo, Medical College of Wisconsin |
Andrew Glickman, Medical College of Wisconsin |
David Gafney, Medical College of Wisconsin |
David G. Lange, Medical College of Wisconsin |
Kathryn Lamping, Medical College of Wisconsin |
Anne Borkowf, Medical College of Wisconsin |
Zheng-Xiong Xi, Medical College of Wisconsin |
Shan Muthian, Medical College of Wisconsin |
Harold Suh, Medical College of Wisconsin |
Raymond Cameron, Medical College of Wisconsin |
Sachin Patel, Medical College of Wisconsin |
MS Committees |
Heidi Shields, Medical College of Wisconsin |
Martin Volk, Medical College of Wisconsin |
Salman Alfarsi, Medical College of Wisconsin |
Deborah Petersen, Medical College of Wisconsin |
Sheralee Terschner, Medical College of Wisconsin |
Norbert Pontzer, Medical College of Wisconsin |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Undergraduate Students |
1990 - 2002, Experiential Learning Mentor - Minority Apprenticeship in Research Program, Alverno College |
Graduate Students |
MS Committees |
Mark Klevan, Marquette University |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Bloom, A.S., Dewey, W.L., Harris, L.S. and Brosius, K.K.:
The correlation between antinociceptive activity of narcotics and their antagonists as measured in the mouse tail-flick and increased synthesis of brain catecholamines.
J. Pharmacol. Exp. Ther. 198: 33-41, 1976.
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2. Bloom, A.S., Dewey, W.L., Harris, L.S. and Brosius, K.K.:
The relationship between the antinociceptive effects of (+)9-nor-9-OH-hexa-hydrocannibinol and increased brain catecholamine synthesis in the mouse.
J. Pharmacol. Exp. Ther. 200: 263-270, 1977.
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3. Dewey, W.L., Johnson, K.M. and Bloom, A.S.:
Interactions of active constituents of marihuana with other drugs in the neuron.
Ann. New York Acad. Sci. 281: 190-197, 1976.
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4. Bloom, A.S., Quinton, E.E. and Carr, L.A.:
Interaction of cycloheximide and adrenergic drugs with brain protein and catecholamine biosynthesis.
Neuropharmacology 16: 411-418, 1977.
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5. Quinton, E.E. and Bloom. A.S.:
Effect of amphetamine and strychnine on cycloheximide and diethyldithiocarbamate induced amnesia.
J. Comp. Physiol. Physiol. Psych. 91: 1390-1397, 1977.
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6. Bloom, A.S. and Dewey, W.L.:
A comparison of some pharmacological effects of ∆9-THC and morphine in the mouse.
Psychopharmacology 57: 243-248, 1978.
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7. Bloom, A.S., Johnson, K.M. and Dewey, W.L.:
The effects of cannabinoids on body temperature and brain catecholamine synthesis.
Res. Comm. Chem. Path. Pharmacol. 20: 300-307, 1978.
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8. Bloom, A.S., Haavik, C.O. and Strehlow, D.:
Effects of ∆9-tetrahydrocannabinol on ATPases in mouse brain subcellular fractions.
Life Sci. 23: 1399-1404, 1978.
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9. Bloom, A.S. and Kiernan, C.J.:
Interaction of ambient temperature and with the effects of ∆9-tetrahydrocannabinol on brain catecholamine synthesis and plasma corticosterone levels.
Psychopharmacology 67: 215-219, 1980.
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10. Haracz, J.L., Bloom, A.S., Wang, R.I.H. and Tseng, L.F.:
The effect of intraventricular ß-endorphin and morphine on hypothalamic-pituitary adrenal activity on the release of pituitary ß-endorphin.
Neuroendocrinology 33: 170-175, 1981.
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11. Tapper, E.J., Bloom, A.S. and Lewand, D.C.:
Endogenous norepinephrine release induced by tyramine modulates intestinal ion transport.
Amer. J. Physiol. 241: G264-G269, 1981.
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12. Bloom, A.S. and Tseng, L.F.:
Effects of beta-endorphin on body temperature in mice at different ambient temperatures.
Peptides 2: 293-297, 1981.
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13. Johnson, K.M., Dewey, W.L. and Bloom, A.S.:
Adrenalectomy reverses the effects of delta-9-THC on mouse brain 5-hydroxytryptamine turnover.
Pharmacology 23: 223-229, 1981.
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14. Bloom, A.S.: Effect of ∆9-THC on the synthesis of dopamine and norepinephrine in mouse brain synaptosomes. |
15. Hillard, C.J. and Bloom, A.S.: ∆9-Tetrahydrocannabinol induced changes in ß-adrenergic receptor binding in mouse cerebral cortex. Brain Research 235: 370-377, 1982. |
16. Staatz, C.G., Bloom, A.S. and Lech, J.J.: A pharmacological study of mechanisms of pyrethroid neurotoxicity in mice. Pesticide Biochemistry and Physiology 17: 1-6, 1982. |
17. Staatz, C.G., Bloom, A.S. and Lech, J.J.: Effects of pyrethroids on [3H]-kainic acid binding to mouse forebrain membranes. Toxicology and Applied Pharmacology 64: 566-569, 1982. |
18. Bloom, A.S., Staatz, C.G. and Dieringer, T.: Pyrethroid effects on operant responding and feeding. Neurobehavioral Toxicology and Teratology 5: 321-324, 1983. |
19. Hillard, C.J. and Bloom, A.S.: Role of prostaglandins in the effects of the cannabinoids on adenylate cyclase activity. Eur. J. Pharmacology 91: 21-27, 1983. |
20. Hillard, C.J., Farber, N.E., Hagen, T.C. and Bloom, A.S.:The effects of ∆9-tetrahydrocannabinol on plasma thyrotropin levels in the rat. Pharmacology, Biochemistry and Behavior 20: 547-550, 1984. |
21. Hillard, C.J. and Bloom, A.S.: Further studies of the interaction of ∆9-tetrahydrocannabinol with the ß-adrenergic receptors. In The Cannabinoids: Chemical Pharmacologic and Therapeutic Aspects. ed. by A. Agurell, W. Dewey, and R. Willette. Academic Press 591-602, 1984. |
22. Bloom, A.S.: Effects of cannabinoids on neurotransmitter receptors in the brain. In The Cannabinoids: Chemical Pharmacologic and Therapeutic Aspects. ed. by W. Dewey, S. Augerell and R. Willette. Academic Press 575-580, 1984. |
23. Quock, R.M., Bloom, A.S. and Sadowski, J.A.: Possible noradrenergic involvement in naloxone potentiation of apomorphine-induced stereotypic climbing in mice. Pharmacology, Biochemistry and Behavior 21: 733-736, 1984. |
24. Bloom, A.S. and Hillard, C.J.: Cannabinoids, Neurotransmitter Receptors and Brain Membranes. In Marihuana '84 (ed. by D.J. Harvey), 217-231, 1985. |
25. Hillard, C.J., Harris, R.A. and Bloom, A.S. Effects of the cannabinoids on physical properties of brain membranes and phospholipid vesicles: fluorescence studies. J. Pharmacol. Exp. Ther. 232: 579-588, 1985. |
26. Hillard, C.J., Bloom, A.S. and Houslay, M.D.: Effects of ∆9-tetrahydrocannabinol on glucogon receptor coupling to adenylate cyclase in rat liver plasma membranes. Biochem. Pharmacol. 35: 2797-2803, 1986. |
27. Stein, E.A., Washburn, M., Walczak, C. and Bloom, A.S.: Effects of pyrethroid insecticides on operant responding maintained by food. Neurobehav. Toxicol. Teratol. 9: 27-31, 1987. |
28. Martin, B.R., Bloom, A.S., Howlett, A.C. and Welch, S.P.: Cannabinoid action in the central nervous system. NIDA Research Monographs 90: 275-283, 1989 |
29. Hillard, C.J., Pounds, J.J., Boyer, D.R. and Bloom, A.S.: The effects of delta-9-tetrahydrocannabinol on adenylate cyclase activation and membrane lipid ordering in the heart. J. Pharmacol. Exp. Ther.252: 1075-1082,1990 |
30. Kozik, A., Korstowski, W., Sarna, T. and Bloom, A.S.: Studies on the equilibrium binding of riboflavin to DOPA-melanin and some spectroscopic characteristics of flavin-melanin complex. Biophysical Chemistry 38: 39-48, 1990. |
31. Moldovan, J.C., Ward, S.J. and Bloom, A.S.: Cannabinoid-like effects of aminoalkylindole compounds on the physical properties of brain membranes: Fluorescence polarization studies. NIDA Research Monographs 105: 302-303, 1991. |
32. Bloom, A.S. and Swerderski, M.: Effects of cannabinoids on synaptosomal transmembrane potential. NIDA Research Monographs 119: 205, 1992 |
33. Antuono, P.G., Bloom, A.S., Ranvanelli-Meyer, J., Nicholson, K.: Leukocyte hexokinase activity in aging and Alzheimer's Disease. Dementia 6:200-204, 1995. |
34. Bloom, A.S., Tershner, S., Fuller, S. A. and Stein, E. A.: Cannabinoid induced alterations in regional cerebral blood flow in the rat. Pharmacology, Biochemistry and Behavior 57: 625-637, 1997. |
35. Bloom, A.S., Edgemond, W.S. and Moldvan, J.C.: Nonclassical and endogenous cannabinoids: Effects on the ordering of brain membranes. Neurochemical Research 22: 563-568, 1997. |
36. Stein, E.A., Bloom, A.S., Pankiewicz, J., Harsch, H.H., Cho, J.K., Fuller, S.A., Hawkins, M., Bandettini, P.A. and Rao S.M.: Nicotine-induced limbic cortical activation in human brain as revealed by functional MRI. Am. J. Psychiatry 155:1009-1015, 1998. |
37. Bloom, A.S., Hoffmann, R.G., Fuller, S.A., Pankiewicz, J., Harsch, H.H., Stein, E.A.: The determination of drug-induced changes in functional MRI signal using a pharmacokinetic model. Human Brain Mapping 8:235-244, 1999. |
38. Harsch, H.H., Pankiewicz, J., Bloom, A.S., Cho, J-K., Watz, L.S. and Stein, E.A. : Hepatitis C virus infection in cocaine users-a silent epidemic. Community Mental Health Journal 36: 225-233, 2000 |
39. Garavan, H., Pankiewicz, J., Bloom, A., Cho-J-K, Sperry, L., Ross, T., Salmeron, B.J., Risinger, R., Kelley, D. and Stein, E.A.: Cue-induced cocaine craving: neuroanatomical specificity for drug users and drug stimuli Am. J. Psychiatry 157: 1789-1798, 2000. |
40. Kufahl, P., Li, Z., Risinger,R., Rainey, C., Wu, G., Bloom, A., Li, S.: Neural responses to acute cocaine administration in the human brain detected by fMRI. Neuroimage 28: 904-914, 2005. |
41. Risinger, R.C., Salmeron, B.J., Ross, T.J., Amen, S.L., Sanfilipo, M.J., Hoffmann, R., Bloom, A.S., Garavan, H., Stein, E.A. Neural correlates of high and craving during cocaine self-administration using BOLD fMRI. Neuroimage 26: 1097-1108, 2005. |
42. Liu, H., Rainey, C., Lauer, K.K., Piacentine, L., Bloom, A., Risinger, R., Ward, D,. Stein, E., Li, S-J.: Peripheral blood pressure changes induced by dobutamine do not alter BOLD signals in the human brain. Neuroimage 30: 745-752, 2006. |
43. Murphy, K., Dixon, V., LaGrave, K., Kaufman, J., Risinger, R., Bloom, A., Garavan, H.: A validation of event-related fMRI comparisons between users of cocaine, nicotine, or cannabis and control subjects. 163: 1245-1251, 2006. |
44. Kufahl P, Li Z, Risinger R, Rainey C, Piacentine L, Wu G, Bloom A, Yang Z, Li S-J. Expectation modulates human brain responses to acute cocaine: A functional magnetic resonance imaging study. Biol Psychiatry 63 :222-230, 2008. |
45. Liu X, Yang, Z, Li R, Xie J, Yin Q, Bloom A, Li SJ: Responses of dopaminergic, serotonergic and noradrenergic networks to acute levo-tetrahydropalmatine administration in naive rats at 9.4 Tesla. Accepted with revision - Magnetic Resonance Imaging, (2011) |
Books, Chapters, and Reviews |
1. Stein, E.A., Risinger, R. and Bloom, A.S.,
FMRI in pharmacology. In: Moonen, C. and P.A. Bandettini (eds.),
Medical Radiology. Springer-Verlag, 525-538, 1999.
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2. Bloom, A.S.:
Psychotomimetic Drugs
Basic Pharmacology in Medicine (4th edition), ed. by J.R. DiPalma, G.J. DiGregorio, E.J. Barbieri, A.P. Ferko. West Chester, Medical Surveillance, Inc., 1994.
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Abstracts |
1. Bloom, A.S. and Quinton, E.: Cycloheximide and adrenergic drugs: Effect on passive avoidance. Program of the 1973 Meeting of the Midwestern Psychological Association, p. 83,. |
2. Bloom, A.S., Quinton, E. and Carr, L.: Cycloheximide induced amnesia: Positive involvement of brain catecholamine. Program of 1974 Meeting of the Society for Neuroscience, p. 146, 1974. |
3. Carr, L., Bloom, A. and Quinton, E.: Inhibition of brain protein and norepinephrine synthesis by dithiocarbamate: Possible mechanisms for amnesia effects. Pharmacologist 16: 241, 1974. |
4. Bloom, A.S. and Brosius, K.: The effects of analgesics, narcotic antagonist-analgesics, and narcotic antagonists on the activation of CNS catecholamine containing neurons in mice. Fed. Proc. 34: 787, 1975. |
5. Bloom, A.S., Dewey, W.L., Harris, L.S. and Brosius, K.: Brain catecholamines and the antinociceptive action of (+)9-nor-9-OH hexahydrocannabinol. Neuroscience Abstracts 242: 1975. |
6. Bloom, A.S., Johnson, K.M., Bowman, F.J. and Dewey, W.L.: Correlation between the effects of several cannabinoids on catecholamine biosynthesis, body temperature and behavior. Fed. Proc. 35: 506, 1976. |
7. Pedigo, N.W., Dewey, W.L., Hobson, R.J., Johnson, K.M., Bloom A.S. and Bowman, E.R.: Drug alteration of intraventricularly administered acetylcholine induced antinociception in mice. Fed. Proc. 35: 310, 1976. |
8. Schumann, A.M., Bloom, A.S., Dewey, W.L., Harris, L.S. and Borzelleca, J.F.: Development of central catecholamine systems in the postnatal rat brain. Pharmacologist 18: 243, 1977. |
9. Bloom, A.S., Haavik, C.O. and Hardman, H.F.: Effect of ∆9-tetrahydrocannabinol (THC) in vitro on ATPases in mouse brain subcellular fractions. Fed. Proc. 36: 1027, 1977. |
10. Tapper, E.J., Bloom, A.S. and O'Connell, P.C.: Uptake and release of 3H-norepinephrine in ileal mucosa. Neuroscience Abstracts 3: 418, 1977. |
11. Bloom, A.S. Kiernan, C.J. and Haavik, C.O.: ∆9-Tetrahydrocannabinol (THC) induced increase in brain catecholamine synthesis and plasma corticosterone (CS) levels in the absence of hypothermia. Fed. Proc. 37: 737, 1978. |
12. Bloom, A.S., Kiernan, C.J. and Halloin, T.J.: Effects of ∆9-tetrahydrocannabinol (THC) on the synthesis of catecholamines in brain synaptosomes. 7th International Congress of Pharmacology 607, 1978. |
13. Haavik, C.O., Bloom, A.S. and Hardman, H.F.: Effect of sodium and calcium ions on ∆9-tetrahydrocannabinol induced hypothermia in the mouse. 7th International Congress of Pharmacology 79, 1978. |
14. Bloom, A.S. and Tseng, L.F.: Effects of ß-endorphin on body temperature in the mouse. Neuroscience Abstracts 5: 524, 1979. |
15. Bloom, A.S., Nabena, C.N. and Kiernan, C.J.: Effect of ∆9-tetrahydrocannabinol on the synthesis of dopamine and norepinephrine in striatal and brainstem synaptosomes. Fed. Proc. 38: 590, 1979. |
16. Kiernan, C.J. and Bloom, A.S.: Effects of ∆9-tetrahydrocannabinol and analogs on 3H-dihydroalprenalol binding in mouse cerebral cortex. Fed. Proc. 39: 849, 1980. |
17. Haracz, J.L., Bloom, A.S., Wang, R.I.H. and Tseng, L.F.: Effect of intraventricular ß-endorphin and morphine on the release of pituitary ß-endorphin and ACTH. Fed. Proc. 39: 605, 1980. |
18. Staatz, CG., Bloom, A.S. and Lech, J.J.: A pharmacological analysis of mechanisms of permethrin neurotoxicity in mice. Fed. Proc. 39: 624, 1980. |
19. Bloom, A.S. and Hardman, H.F.: Cannabinoid effects on the synthesis of dopamine and norepinephrine in mouse brain synaptosomes. Fed. Proc. 40: 600, 1981. |
20. Staatz, CG., Lech, J.J. and Bloom, A.S.: Interaction of synthetic pyrethroid insecticides with kainic acid and their effect on kainic acid binding to mouse forebrain membranes. Neuroscience Abstracts 7: 162, 1981. |
21. Hillard, C.J. and Bloom, A.S.: ∆9-Tetrahydrocannabinol (THC) induced changes in basal and norepinephrine-stimulated adenylate cyclase activities in mouse cerebral cortex. Neuroscience Abstracts 7: 448, 1981. |
22. Bloom, A.S. and Staatz, C.G.: Effects of permethrin, a synthetic pyrethroid insecticide on operant behavior and feeding. Neuroscience Abstracts 7: 162,1981. |
23. Greathouse, J.K. and Bloom, A.S.: Developmental changes in enkephalin levels in mouse brain. Pharmacologist 24: 119, 1982. |
24. Hillard, C.J. and Bloom, A.S.: Differential effect of ∆9-tetrahydrocannabinol on the binding of agonists and antagonists to the -adrenergic receptor. Neuroscience Abstracts 8: 1030, 1982. |
25. Bloom, A.S., Dieringer, T.M. and Greathouse, J.K.: Effects of cannabinoids on the binding to dopaminergic receptors in mouse brain. Naloxone potentiation of apomorphine-induced stereotypic climbing in mice: Influence of drug pretreatments that alter levels of brain catecholamines. Neuroscience Abstracts 8: 481, 1982. |
26. Hillard, C.J., Hagen, T.C. and Bloom, A.S.: Effects of ∆9-tetrahydrocannabinol on plasma thyrotropin levels in the rat. Fed. Proc. 42: 167, 1983. |
27. Hillard, C.J. and Bloom, A.S.: GTP decreases antagonist binding to ß-adrenergic receptors of mouse cerebral cortex. Neuroscience Abstracts 9: (1117), 1983. |
28. Bloom, A.S., Dieringer, T.M., Greathouse, J.K. and Kobs, J.K.: Effects of delta-9-tetrahydrocannabinol (THC) on endogenous opioids and opioid receptors. Neuroscience Abstracts 9: (1145), 1983. |
29. Hillard, C.J., Harris, R.A. and Bloom, A.S.: The effects of cannabinoids on fluidity of brain synaptic membranes. Fed. Proc. 43: 951, 1984. |
30. Hillard, C.J. and Bloom, A.S.: GTP reverses the effects of ∆9-tetrahydrocannabinol on the binding of antagonists to the ß-adrenergic receptor. Neuroscience Abstracts 10: 1209, 1984. |
31. Hillard, C.J., Bloom, A.S. and Houslay, M.D.: Effect of ∆9-tetrahydrocannabinol on glucagon receptor coupling to adenylate cyclase in liver membranes. Pharmacologist 27: 165, 1985. |
32. Stein, E.A., Washburn, M. Wolczak, C. and Bloom, A.S.: Acute and chronic effects of pyrethroid insecticides on operant responding for food. Neuroscience Abstracts 11: 632, 1985. |
33. Bloom, A.S., Sutherland, L.A., Hillard, C.J. and Stein, E.A.: Effect of pyrethroid insecticides on the binding of 3H-glutamate to rat brain membranes. Neuroscience Abstracts 11: 632, 1985. |
34. Bloom, A.S., Hillard, C.J. and Pounds, J.J.: Effect of ∆9-tetrahydrocannabinol on adenylate cyclase activity in ventricular membranes. Neuroscience Abstracts 12: 999, 1986. |
35. Stein, E.A., Walczak, C. and Bloom, A.S.: Effects of pyrethroids on intracranial self-stimulation. Neuroscience abstracts 12: 1201, 1986. |
36. Bloom, A.S., Hillard, C.J., Boyer, D.R. and Merkle, H.: Effects of the cannabinoids on the physical properties of model membranes studied using time-dependent decay of fluorescence anisotropy. Fed. Proc. 45: 1058, 1986. |
37. Bloom, A.S., Pounds, J.J. and Hillard, C.J.: Differences in the effects of cannabinoids on plasma membranes from brain, heart and liver as determined by fluorescence polarization. Pharmacologist 29: 56, 1987. |
38. Bloom, A.S. and Accardi, A.T.: Effects of pyrethroid insecticides on the active uptake of glutamate into rat brain synaptosomes. Neuroscience Abstracts 13: 91, 1987. |
39. Bloom, A.S. and Hillard, C.J.: Effects of chronic ∆9-tetrahydrocannabinol (THC) treatment on the fluidity of brain synaptic plasma membranes (SPM). Fed. Proc. 2: 1806, 1988. |
40. Moldovan, J.C. and Bloom, A.S.: Effects of aminoalkylindole compounds on the fluidity of biological and artificial membranes. Pharmacologist 32: 126, 1990. Antuono, P.G., Bloom, A.S. and Sisola C.: Impaired membrane fluidity in Alzheimer's Disease. Neurology 41: 269, 1990. |
41. Bloom, A.S., Fuller, S.A. and Stein, E.A.: Effects of ∆9-tetrahydrocannabinol on regional cerebral blood-flow in the rat. Neuroscience Abstracts 16: 1101, 1990 |
42. Bloom, A. S., Antuono, P.G. and Vena, L.F.: Alterations in the physical properties of brain membranes in Alzheimer's Disease. Neuroscience Abstracts 17: 1070, 1991 |
43. Antuono, P., Nicholson, K. and Bloom, A.: Alterations in the physical properties of leukocycte membranes in Alzheimer's Disease. Neuroscience Abstracts 18: 738, 1992. |
44. Bloom, A. S., Tershner, S., Fuller, S. A. and Stein, E. A.: Cannabinoid induced alterations in regional cerebral blood flow in the rat. Neuroscience Abstracts 18: 372, 1992. |
45. Antuono, P., Dal Forno, G. Ho, K.C. Beyer, J. and Bloom, A.: The Wisconsin Alzheimer Disease Brain Bank: Results of 209 cases. World Congress of Psychiatry, 1993. |
46. Dal Forno, G., Antuono, P. G., Bloom, A., Beyer, J., Hellman, R. S. and Tikofsky, R. The role of single photon computed tomography (SPECT), in the early diagnosis of Alzheimer's disease. Neurology, 1993. |
47. Bloom, A.S., Bunch, B., Lamers, L. Nicholson, K. and Antuono, P.G.: Alterations in the transmembrane potential of synaptosomes prepared from Alzheimer's disease brains. Neurobiology of Aging 15: S13, 1994 |
48. Antuono, P., Jones, J., Dal Forno, G., Ho, K-C, Beyer, J., Nicholson, K. and Bloom, A.: Clinical pathological correlations in 290 consecutive autopsies in patients with dementia. Neurobiology of Aging 15: S110, 1994 |
49. Beyer, J., Moser, S., Jones, J., Keyes, B., Ullman, J. Ravanelli-Meyers, J., Kalman, A., Bloom, A. and Antuono, P.: The differential role of the Alzheimer's Association and a dementia clinic in addressing the community needs. Neurobiology of Aging 15: S108, 1994. |
50. Bloom, A.S., Rao, S.M, Bobholz, J.A., Hammeke, T.A., Fuller, S.A., Binder, J. R. Cox, R.C., Pankiewicz, J., Harsch, H.H., Cho, J-K., Rossing, M., Stein, E.A.: Cerebral activation by a working memory task.: A human FMRI study. Neuroscience Abstracts 21: 1441, 1995 |
51. Stein, E.A., Pankiewicz, J., Harsch, H.H., Rossing, M., Cho, J-K., Fuller, S.A., Rao, S.M., Bloom, A.S.: Cocaine-induced alterations of brain activity in humans: An FMRI study. Neuroscience Abstracts 21: 1956, 1995. |
52. Stein, E.A., Rao, S.M., Bobholz, J.A., Fuller, S.A., Bloom, A.S., Cho, J-K., Pankiewicz, J.,Harsch, H.H.: Functional MRI of human spatial working memory. Human Brain Mapping S1: 32, 1995 |
53. Bloom, A.S., Li, S. J., Wang, Y., Pankiewicz, J., Harsch, H.H., Cho, J-K.,Prost, R., Stein, E.A.: Alterations in brain chemistry of cocaine abusers studied using 1H magnetic resonance spectroscopy. NIDA Research Monographs ,174: 118, 1997. |
54. Bloom, A.S., Wright, J., Pankiewicz, J., Rao, S.M., Cho, J.K., Harsch, H.H., Fuller, S.A., Wang, Y., Watz, L.S., Stein, E.A.: Altered cognitive task-induced brain activation during nicotine withdrawal: A human FMRI study. NIDA Research Monographs, 174: 118, 1997. |
55. Bloom, A.S., Wright, J., Ross, T.J., Rao, S.M., and Stein, E.A.: Between session reproducibility of cognitive task-induced brain activation. Neuroimage ,7: S614, 1998. |
56. Bloom, A.S., Wright, J., Hegerty, B., Tadros, S. Rao, S.M, Sperry, L.S., Ross, T.J. and Stein, E.A.: Altered cognitive task-induced brain activation in chronic cigarette smokers: A human FMRI study. NIDA Research Monographs, 179:187, 1998. |
57. Garavan, H., Bloom, A., Sperry, L., Risinger, R., Salmeron, BJ, Salm, T, Stein, EA., Cognitive Dimensions of Cue-induced Cocaine Craving. Society for Neuroscience, Annual Meeting, 1998 |
58. Li,S-J., Wang, Y. Risinger, R., Rainey, C, Harsch, H, Pankiewicz, J, Sperry, L., Cho, J-K, Bloom, AS, Stein, EA.: Acute Cocaine Administration Induces NAA Increases Detected by 1H-MRS. International Society for Magnetic Resonance in Medicine, 1998. |
59. Garavan, H., Bloom, A., Sperry, L., Pankiewicz, J., Ward, D., Risinger, R., Salm, T. and Stein E. Limbic and cortical activation specific to cue-induced cocaine craving. NIDA Research Monographs, 179:108, 1998. |
60. Ward, B.D., Garavan, H., Ross, T.J., Bloom, A.S., Cox, R.W., Stein, E.A.: Nonlinear regression for fMRI time series analysis. Neuroimage, 7: S767, 1998. |
61. Bloom, A. S., Risinger, R. C., Ross, T.J., Stein, E. A.: Effects of delta9 tetrahydrocannabinol (THC) on brain activity and cognitive task-induced brain activation: A fMRI study. NIDA Research Monographs 180: 282, 2000. |
62. Ross, T.J., Williams, S.A., Risinger, R.C., Salmeron, B.J., Bloom, A.S., and Stein, E.A. Evidence of chronic tolerance to nicotine as measured with fMRI. Proc. Intl. Soc. Mag. Reson. Med,. 9: 2001 |
63. Bloom, A.S., Risinger R.C., Ross, T.J., Pendergrass C. and Stein, E.A., Effects of tetrahydrocannabinol (THC) on brain activity and perfusion in humans: A functional magnetic resonance imaging study. Drug and Alcohol Dependence, 2001. |
64. Mu, Q., Ross, T.J., Risinger, R., Salmeron, B., Rainey, C., Bloon, A., Stein, E.A. Dose-dependent effects of iv cocaine in human brain. Neuroimage 13: S1077, 2001 |
65. Bloom, A. S., Risinger, R. C., Ross, T. J., Sanders, J. and Stein, E. S., Dose-dependent effects of tetrahydrocannabinol (THC) on brain activity in humans: A functional magnetic resonance imaging study. Neuroscience Abstracts, 2001. |
66. Bloom, A. S., Benson, J. C., LaGrave, K. B., Piacentine, L. B. and Risinger, R. C., Effects of tetrahydrocannabinol on cerebral blood flow in humans measured using arterial spin labeling (ASL). Neuroscience Abstracts, 2002 . |
67. Risinger, R.C., Dixon, V., Ross, T., Ward, D., Li, S.J., Bloom, A., Stein, E. Active human cocaine self-administration is associated with MCL circuit activity. CPDD Meetings, Abstracts Miami, 2003 |
68. Benson, J.C., LaGrave, K.B., Piacentine, L.B., Risinger, R.C., Bloom, A.S. Effects of intravenous tetrahydrocannabinol on cerebral blood flow: A BOLD versus arterial spin labeling fMRI study. CPDD Meetings, Abstracts Miami, 2003 |
69. Bloom, A.S., LaGrave, K., Piacentine, L., Benson, J., Risinger, R. Effects of Delta-9-THC on task activation measured using fMRI. 9th International Conference on Functional Mapping of the Human Brain 2003, New York, Neuroimage, 19: CD-Rom. |
70. Risinger, R.C., Amen, S.L., Salmeron, B.J., Ross, T.J., Hoffmann, R.G., Bloom, A.S., Li, S.J., Stein, E.A., Rapid phasic BOLD signal changes during human cocaine self-administration. CPDD Meetings, Abstracts San, Juan, 2004. |
71. Bloom, A. S. Effects of chronic marijuana use and THC on brain function in humans: American Psychiatric Meeting Proceedings, Invited Presentation, 2004, New York City. |
72. Bloom, P.L., Bloom, A.S., Piacentine, L., LaGrave, K., Benson, J. Individual characteristics and response to THC administration in marijuana users. American Psychological Association Meeting Abstracts, 2004 |
73. Liu, H., Rainey, C., Lauer, K., Piacentine, L., Bloom, A., Risinger, R., Stein, E., Li, S-J. The effects of dobutamine-induced blood pressure changes on BOLD fMRI signals in the Human Brain. Proc. Intl. Soc. Mag. Reson. Med, Miami Beach, 2005 |
74. Bloom, A.S., Janke, K., Piacentine, L., Mitton, E., Yadav, R., Risinger, R.C., Li, S.J. Regional differences in the pharmacokinetic modeling of response to delta9-tetrahydrocannabinol. Neuroimage, 21: CD-ROM, 2005. |
75. O' Hanlon, E., Bloom, A., Garavan, H. Grey and white matter volume differences in cocaine, cannabis and nicotine users compared to controls: A voxel based morphometry study. Neuroimage, 22: CD-ROM, 2006. |
76. Kufahl, P.R., Risinger, R.C., Bloom, A.S., Li, S.J., Extraction of pharmacokinetic parameters from human brain cocaine BOLD responses. Proc. Intl. Soc. Mag. Reson. Med, Seattle, WA, 2006 |
77. LaViolette, P.S., Collier, W., Schmainda, K.M., Douville, K.L., Chitambar, C.R., Tran, A., Claesges, S.A., Durgerian, S. J., Bloom, A.S. Functional connectivity and arterial spin labeling in chemotherapy induced cognitive impairment (Chemobrain). 2009 Meeting of the International Society for Magnetic Resonance Medicine, Honolulu, HI. |
78. LaViolette, P.S., Collier, W., Verber, M.D., Schmainda, K.M., Piacentine, L., Douville, K.L., Claesges, S.A., Durgerian, S. J., Bloom, A.S. Functional connectivity of the insula of smokers. 2009 Meeting of the International Society for Magnetic Resonance Medicine, Honolulu, HI. |
79. Bloom, A.S., Cios, H., Collier, W., Douville, K., Durgerian, S., Li, S. J., Chang, L. A BOLD fMRI study of cannabinoid action in rat brain. 2009 Meeting of the College on Problems of Drug Dependence, Reno, NV. |
80. Bloom, A.S., LaViolette, P.S., Chitambar, C.R., Collier, W., Durgerian, S.J., Kalyanaraman, B., McAllister, D.M., Williams, C.L., Schmainda, K.M. Effects of Doxorubicin on Brain Activity and Functional Connectivity in Rats. 2010 Meeting of the International Society for Magnetic Resonance Medicine, Stockholm, Sweden |
81. A.T. Barr, C.J. Ford1, P.S. LaViolette, C.R. Chitambar, W. Collier, S.J. Durgerian, L. Piacentine, K.L. Douville S.A. Claesges, B. Kalyanaraman, D.M. McAllister, C.L, Williams, K.M. Schmainda and A.S. Bloom, Breast Cancer Adjuvant Chemotherapy Induced Changes in Functional Connectivity in Female Breast Cancer Patients and a Rodent Model of Chemotherapy,. Proceedings of the Second Biennial International conference on Resting-State Functional Brain Connectivity, Milwaukee, Wisconsin pp. O18, 2010. |
82. Alan Bloom, William Collier, Sally Durgerian, Peter LaViolette, Balaraman Kalyanaraman, Carol Williams, Kathleen Schmainda Effects of Doxorubicin on Brain Activity and Resting-State Functional Connectivity in Rats: fMRI Studies 2011 Era of Hope Conference - Orlando FL |
