Medical College of Wisconsin
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CURRICULUM VITAE

Andrew Spearman MD
Assistant Professor
Department of Pediatrics
Division of Cardiology

OFFICE ADDRESS:
Children's Hospital
9000 W Wisconsin Ave
Milwaukee, WI 53226
Email: aspearman@mcw.edu

EDUCATION:
2004 - 2008 BS, Biology, The Ohio State University, Columbus, OH
2008 - 2012 MD, New York University School of Medicine, New York, NY

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
2012 - 2015 Pediatric Residency, University of Chicago, Chicago, IL
2015 - 2018 Pediatric Cardiology Fellowship, Medical College of Wisconsin, Milwaukee, WI
2018 - 2019 Post-Doctoral Research Fellowship, Vascular Biology, Medical College of Wisconsin, Milwaukee, WI
2021 - 2023 Clinical Research Scholars Program, Clinical and Translational Science Institute, Medical College of Wisconsin, Milwaukee, WI

FACULTY APPOINTMENTS:
2018 - 2019 Instructor, Department of Pediatrics, Division of Cardiology, Medical College of Wisconsin, Milwaukee, WI
2019 - Present Assistant Professor, Department of Pediatrics, Division of Cardiology, Medical College of Wisconsin, Milwaukee, WI

SPECIALTY BOARDS AND CERTIFICATION:
Board Certified
Issue DateExpiration
American Board of Pediatrics
2015
None
American Board of Pediatrics, Subspecialty Board for Cardiology
2018
None
   
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
2012 - Present American Academy of Pediatrics
2018 - Present American Heart Association
2020 - Present North American Vascular Biology Organization (NAVBO)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Journal Review
2018 - Present World Journal for Pediatric and Congenital Heart Surgery
2019 - Present Cardiology in the Young
2019 - Present Journal of the American Heart Association
2019 - Present American Journal of Physiology - Heart and Circulatory Physiology
2020 - Present PLOS ONE
2021 - Present Journal of Molecular Medicine

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Understanding the role of sFLT1 in pulmonary arteriovenous malformations
Source:
NIH/NHLBI Loan Repayment Program
Role:
PI
Dates:
07/01/2020 - 06/30/2022
  
Title:
Investigation of hepatic factor in pulmonary arteriovenous malformations
Source:
NHLBI K08HL157510
Role:
PI
Dates:
04/01/2022 - 03/31/2027
  
Prior
Peer Review
Title:
Candidate identification for the elusive hepatic factor
Source:
Mend A Heart Foundation
Role:
Co-PI
PI:
Ramani Ramchandran, PhD
Dates:
2018 - 2019
  
Title:
Analysis of hepatocyte-derived sVEGFR1 in pulmonary microvascular angiogenesis and remodeling
Source:
AHW/HHI Innovation Award
Role:
PI
Dates:
09/01/2020 - 08/31/2021
  
Title:
Analysis of hepatocyte-derived sVEGFR1 in pulmonary arteriovenous malformations
Source:
Mend a Heart Foundation
Role:
PI
Dates:
11/01/2020 - 10/31/2021
  
Title:
Pulmonary arteriovenous malformations in univentricular congenital heart disease
Source:
Children's Wisconsin Research Institute
Role:
PI
Dates:
01/01/2021 - 12/31/2021
  

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
Clinical Case Presenation, S. Bert Litwin Lectureship, Children's Wisconsin, Milwaukee, WI, 2016
Adverse early life environment increases mRNA expression of genes involved in cardiac fibrosis, Children's Research Institute, Children's Wisconsin, Milwaukee, WI, 2017
Adverse maternal environment increases susceptibility to insulin resistance and cardiac fibrosis in adult mice, Children's Research Institute, Children's Wisconsin, Milwaukee, WI, 2018
Clinical Case Presentation, William Gallen Lectureship, Children's Wisconsin, Milwaukee, WI, 2018
Pulmonary arteriovenous malformations: a translational research perspective, William Gallen Lectureship, Children's Wisconsin, Milwaukee, WI, 2019
Pulmonary AVMs in palliated single ventricle congenital heart disease, Children's Research Institute Research Conference, Children's Wisconsin, Milwaukee, WI, 2020
Hepatic factor and pulmonary AVMs: What do we know?, Herma Heart Institute - Quality, Outcomes, Research Seminar Series, Children's Wisconsin, Milwaukee, WI, 2020
Hepatopulmonary signaling and pulmonary AVMs in congenital heart disease, MCW Cardiovascular Center Seminar Series, Milwaukee, WI, 2021
Pulmonary AVMs in congenital heart disease, MCW Department of Pediatrics Scholarship in Progress, Milwaukee, WI, 2022
Aortopulmonary collaterals - when, where, and how?, Herma Heart Institute - Quality, Outcomes, Research Seminar Series, Children's Wisconsin, Milwaukee, WI, 2022
Endothelial cell polarization & vascular homeostasis, Children's Research Institute Research Conference, Children's Wisconsin, Milwaukee, WI, 2022
 
International
Pulmonary arteriovenous malformations: a translational research perspective, Vasculata, North American Vascular Biology Association, Milwaukee, WI, 2019
 

PEER REVIEWED WORKSHOPS/PRESENTATIONS:
Regional
Van Galder H, Schaal AM, Feng M, Pan AY, Frommelt MA, Ginde S, Spearman AD, Investigating susceptibility to pulmonary arteriovenous malformations prior to Fontan palliation in heterotaxy, Midwest Pediatric Cardiology Meeting, Virtual Meeting, 2020
Calley BJ, Pan AY, Liegl MN, Zhang L, Kindel SJ, Ginde S, Spearman AD, Respiratory viral infections in patients with single ventricle congenital heart disease., Midwest Pediatric Cardiology Meeting, Virtual Meeting, 2021
 
National
Spearman AD, Loomba RS, Danduran M, Kovach J., Intrauterine growth restriction is not associated with decreased exercise capacity in adolescents with congenital heart disease, American Academy of Pediatrics National Conference & Exhibition, Chicago, IL, 2017
Spearman AD, Gudausky TM, Foerster SR, Konduri GG, Ramchandran R, Superior vena cava blood up-regulates RNA expression of vascular remodeling pathways in lung endothelial cells, American Heart Association Scientific Sessions, Virtual meeting, 11/2021 - Present
 
International
Spearman AD, Linder JR, Williams P, Pediatric resident ECG interpretation and intervention abilities, Pediatric Academic Societies Meeting, San Diego, CA, 2015
Spearman AD, Ke X, Fu Q, Lane RH, Majnik A, Adverse early life environment increases mRNA expression of genes involved in cardiac fibrosis., Pediatric Academic Societies Meeting, San Francisco, CA, 2017
Spearman AD, Ke X, Fu Q, Lane RH, Majnik A., Adverse maternal environment increases susceptibility to cardiac fibrosis in adult mice, Pediatric Academic Societies Meeting, Toronto, Ontario, 2018
 

COMMITTEE SERVICE:
Medical College of Wisconsin
2018 Cardiovascular Center Research Retreat Abstract Selection Committee, Medical College of Wisconsin
2020 Grant Reviewer, Cardiovascular Center, Medical College of Wisconsin
2020 - 2021 Grant Reviewer, Advancing a Healthier Wisconsin: Collaborative Research for Improved Health, Basic Science Review Panel, Advancing a Healthier Wisconsin
 
Hospital
2017 - Present Pediatric Resident Intern Selection Commitee, Pediatrics, Children's Wisconsin
2018 - Present Pediatric Cardiology Fellowship Selection Committee, Pediatrics, Children's Wisconsin
2020 Grant Reviewer, Children's Research Institute Pilot Innovation Award, Children's Research Institute, Children's Wisconsin
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Spearman AD, Sweet K, Zhou XP, McLennan J, Couch FJ, Toland AE. Clinically applicable models to characterize BRCA1 and BRCA2 variants of uncertain significance. J Clin Oncol. 2008 Nov 20;26(33):5393-400. PMCID: PMC2651073
2. Dworkin AM, Spearman AD, Tseng SY, Sweet K, Toland AE. Methylation not a frequent "second hit" in tumors with germline BRCA mutations. Fam Cancer. 2009;8(4):339-46.
3. Spearman AD, Williams P. Supraventricular tachycardia in infancy and childhood. Pediatr Ann. 2014 Nov;43(11):456-60.
4. Spearman AD. Epigenetics for the pediatric cardiologist. Congenit Heart Dis. 2017 Dec;12(6):828-833.
5. Spearman AD, Loomba RS, Danduran M, Kovach J. Intrauterine growth restriction is not associated with decreased exercise capacity in adolescents with congenital heart disease. Congenit Heart Dis. 2018 May;13(3):369-376.
6. Spearman AD, Hraska V, Goot BH. Isolated Left Innominate Artery: Diagnosis of a Rare Aortic Arch Anomaly. World J Pediatr Congenit Heart Surg. 2018 11;9(6):708-709.
7. Spearman AD, Ke X, Fu Q, Lane RH, Majnik A. Adverse maternal environment leads to cardiac fibrosis in adult male mice. Birth Defects Res. 2018 12 01;110(20):1551-1555.
8. Spearman AD, Kindel SJ, Woods RK, Ginde S. Arteriovenous fistula creation for hypoxia after single ventricle palliation: A single-institution experience and literature review. Congenit Heart Dis. 2019 Nov;14(6):1199-1206.
9. Thirugnanam K, Cossette SM, Lu Q, Chowdhury SR, Harmann LM, Gupta A, Spearman AD, Sonin DL, Bordas M, Kumar SN, Pan AY, Simpson PM, Strande JL, Bishop E, Zou MH, Ramchandran R. Cardiomyocyte-Specific <i>Snrk</i> Prevents Inflammation in the Heart. J Am Heart Assoc. 2019 11 19;8(22):e012792. PMCID: PMC6915262
10. Spearman AD, Ginde S. Pulmonary arteriovenous malformations in children with palliated univentricular CHD: our limited understanding persists. Cardiol Young. 2020 04;30(4):597-598.
11. Spearman AD, Gupta A, Pan AY, Gronseth EI, Thirugnanam K, Gudausky TM, Foerster SR, Ramchandran R. Hepatic Vein Blood Increases Lung Microvascular Angiogenesis and Endothelial Cell Survival-Toward an Understanding of Univentricular Circulation. Semin Thorac Cardiovasc Surg. 2020 Winter;32(4):980-987. PMCID: PMC7647938
12. Spearman AD, Ginde S, Goot BH, Schaal AM, Feng M, Pan AY, Frommelt MA, Frommelt PC. Echocardiographic Identification of Pulmonary Artery Flow Reversal: An Indicator of Adverse Outcomes in Single Ventricle Physiology. Pediatr Cardiol. 2020 Dec;41(8):1632-1638.
13. Van Galder H, Schaal AM, Feng M, Pan AY, Frommelt MA, Ginde S, Spearman AD. Increases in oxygen saturation following discharge from Fontan palliation - an indicator of resolution of pulmonary arteriovenous malformations? Cardiol Young. 2021 Nov;31(11):1807-1813.
14. Spearman AD, Gupta A, Pan AY, Gudausky TM, Foerster SR, Konduri GG, Ramchandran R. sVEGFR1 Is Enriched in Hepatic Vein Blood-Evidence for a Provisional Hepatic Factor Candidate? Front Pediatr. 2021;9:679572. PMCID: PMC8236596
15. Gupta A, Thirugnanam K, Thamilarasan M, Mohieldin AM, Zedan HT, Prabhudesai S, Griffin MR, Spearman AD, Pan A, Palecek SP, Yalcin HC, Nauli SM, Rarick KR, Zennadi R, Ramchandran R. Cilia proteins are biomarkers of altered flow in the vasculature. JCI Insight. 2022 03 22;7(6). PMCID: PMC8986075
16. Calley BJ, Zhang L, Pan AY, Ginde S, Kindel SJ, Spearman AD. Respiratory viral infections are prevalent but uncomplicated in single ventricle CHD. Cardiol Young. 2022 Apr 19:1-7.