Medical College of Wisconsin
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CURRICULUM VITAE

Angela Mathison PhD
Assistant Professor
Department of Surgery
Division of Administration

OFFICE ADDRESS:
Translational and Biomedical Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
01/01/2008 - 07/01/2017 Sr. Research Technologist, Gastroenterology Unit, Mayo Clinic, Rochester, MN

FACULTY APPOINTMENTS:
08/2018 - Present Assistant Professor, Department of Surgery, Division of Research, The Medical College of Wisconsin, Milwaukee, WI

ADMINISTRATIVE APPOINTMENTS:
07/2017 - Present Director of 'Omics Research and Development, Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Establishing Wisconsin's First Cancer Precision Medicine Simulation Unit
Source:
Medical College of Wisconsin; Advancing A Healthier Wisconsin Endowment
Role:
Faculty
PI:
Dr. Raul Urrutia
Dates:
02/2019 - 01/2023
  
Title:
Targeting Epigenomic Regulators at the Replication Fork in PDAC
Source:
R01 CA247898
Role:
Co-Investigator
PI:
Dr. Gwen Lomberk
Dates:
04/01/2021 - 03/31/2026
  

PEER REVIEWED WORKSHOPS/PRESENTATIONS:
National
A Mathison, L Eskra, G Splitter, Macrophage transcript levels altered by Brucella infection reveal host mechanisms specific to pathogenic B. melitensis, 57th Annual Brucellosis Research Conference, Chicago, IL, 11/2004
A Mathison, J Harms, L Eskra, G Splitter, Alteration of the Fc gamma Receptor I in murine macrophages during a Brucella species infection, 59th Annual Brucellosis Research Conference, Chicago, IL, 12/2006
A Mathison, G Lomberk, JS Zhang, A Conde Perez, L Miller, and R Urrutia, The Gbeta subunit of heterotrimeric G proteins links pancreatic GPCR activation to long term responses, American Pancreatic Association Annual Meeting, Chicago, IL, 11/2008
G Lomberk, A Mathison, and R Urrutia, Epigenetic Regulation Downstream of KRAS by the HP1-Histone Methyl Transferase Pathway Mediates Pancreatic Cancer Growth, American Pancreatic Association Annual Meeting, Kohala Coast, HI, 11/2014
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Graduate Student Education
01/2018 - Present Teach Next Generation Sequencing Lecture once per year for Functional Genomics Course
09/2020 - Present Teach Next Generation Sequencing Lecture once per year for Techniques in Molecular and Cellular Biology Course
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
Undergraduate Students
Nalini Singh, Undergraduate Research Employment Program (UREP), 06/2013 - 08/2013 Research
Raghav Chandra, Undergraduate Research Employment Program (UREP), 06/2013 - 08/2013 Research
Nausheen Singh, Undergraduate Research Employment Program (UREP), 06/2013 - 08/2013 Research
Ishtpreet Singh, Summer Undergraduate Research Fellowship (SURF), 06/2014 - 08/2014 Research
Irina Horwath, Summer Undergraduate Research Fellowship (SURF), 06/2014 - 08/2014 Research
Kelly Aukes, Summer Undergraduate Research Fellowship (SURF), 06/2014 - 08/2014 Research
Elise Sloey, Program for Undergraduate Research Experience (PURE), 08/2017 - 12/2017 Research
Charles Met, Summer Program for Undergraduate Research (SPUR), 06/2021 - 08/2021 Research
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Strack A, Duffy CF, Malvey M, Arriaga EA. Individual mitochondrion characterization: a comparison of classical assays to capillary electrophoresis with laser-induced fluorescence detection. Anal Biochem. PubMed PMID: 11444809.
2. Eskra L, Mathison A, Splitter G. Microarray analysis of mRNA levels from RAW264.7 macrophages infected with Brucella abortus. Infect Immun. 2003 Mar;71(3):1125-33. PMCID: PMC148819
3. Rajashekara G, Krepps M, Eskra L, Mathison A, Montgomery A, Ishii Y, Splitter G. Unraveling Brucella genomics and pathogenesis in immunocompromised IRF-1-/- mice. Am J Reprod Immunol. 2005 Dec;54(6):358-68.
4. Rajashekara G, Eskra L, Mathison A, Petersen E, Yu Q, Harms J, Splitter G. Brucella: functional genomics and host-pathogen interactions. Anim Health Res Rev. 2006 Jun-Dec;7(1-2):1-11.
5. Lomberk G, Mathison AJ, Grzenda A, Urrutia R. The sunset of somatic genetics and the dawn of epigenetics: a new frontier in pancreatic cancer research. Curr Opin Gastroenterol. 2008 Sep;24(5):597-602. PMCID: PMC2941574
6. Covert J, Mathison AJ, Eskra L, Banai M, Splitter G. Brucella melitensis, B. neotomae and B. ovis elicit common and distinctive macrophage defense transcriptional responses. Exp Biol Med (Maywood). 2009 Dec;234(12):1450-67. PMCID: PMC2880867
7. Mathison A, Liebl A, Bharucha J, Mukhopadhyay D, Lomberk G, Shah V, Urrutia R. Pancreatic stellate cell models for transcriptional studies of desmoplasia-associated genes Pancreatology. October 2010;10(4):505-516.
8. Daftary GS, Lomberk GA, Buttar NS, Allen TW, Grzenda A, Zhang J, Zheng Y, Mathison AJ, Gada RP, Calvo E, Iovanna JL, Billadeau DD, Prendergast FG, Urrutia R. Detailed structural-functional analysis of the Kr??ppel-like factor 16 (KLF16) transcription factor reveals novel mechanisms for silencing Sp/KLF sites involved in metabolism and endocrinology. J Biol Chem. 2012 Mar 02;287(10):7010-25. PMCID: PMC3293586
9. Lomberk G, Mathison AJ, Grzenda A, Seo S, DeMars CJ, Rizvi S, Bonilla-Velez J, Calvo E, Fernandez-Zapico ME, Iovanna J, Buttar NS, Urrutia R. Sequence-specific recruitment of heterochromatin protein 1 via interaction with Kr??ppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases. J Biol Chem. 2012 Apr 13;287(16):13026-39. PMCID: PMC3339955
10. Seo S, Lomberk G, Mathison A, Buttar N, Podratz J, Calvo E, Iovanna J, Brimijoin S, Windebank A, Urrutia R. Kr??ppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells. J Biol Chem. 2012 Apr 13;287(16):12723-35. PMCID: PMC3339994
11. Grzenda A, Lomberk G, Svingen P, Mathison A, Calvo E, Iovanna J, Xiong Y, Faubion W, Urrutia R. Functional characterization of EZH2I? reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression. Epigenetics Chromatin. 2013 Feb 28;6(1):3. PMCID: PMC3606351
12. Daftary GS, Zheng Y, Tabbaa ZM, Schoolmeester JK, Gada RP, Grzenda AL, Mathison AJ, Keeney GL, Lomberk GA, Urrutia R. A novel role of the Sp/KLF transcription factor KLF11 in arresting progression of endometriosis. PLoS One. 2013;8(3):e60165. PMCID: PMC3610699
13. Lomberk G, Grzenda A, Mathison A, Escande C, Zhang JS, Calvo E, Miller LJ, Iovanna J, Chini EN, Fernandez-Zapico ME, Urrutia R. Kr??ppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young. J Biol Chem. 2013 Jun 14;288(24):17745-58. PMCID: PMC3682574
14. Grzenda A, Leonard P, Seo S, Mathison AJ, Urrutia G, Calvo E, Iovanna J, Urrutia R, Lomberk G. Functional impact of Aurora A-mediated phosphorylation of HP1I? at serine 83 during cell cycle progression. Epigenetics Chromatin. 2013 Jul 05;6(1):21. PMCID: PMC3707784
15. Mathison A, Grzenda A, Lomberk G, Velez G, Buttar N, Tietz P, Hendrickson H, Liebl A, Xiong YY, Gores G, Fernandez-Zapico M, Larusso NF, Faubion W, Shah VH, Urrutia R. Role for Kr??ppel-like transcription factor 11 in mesenchymal cell function and fibrosis. PLoS One. 2013;8(9):e75311. PMCID: PMC3775729
16. Hayashi Y, Asuzu DT, Gibbons SJ, Aarsvold KH, Bardsley MR, Lomberk GA, Mathison AJ, Kendrick ML, Shen KR, Taguchi T, Gupta A, Rubin BP, Fletcher JA, Farrugia G, Urrutia RA, Ordog T. Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways. PLoS One. 2013;8(10):e76822. PMCID: PMC3792098
17. de Assuncao TM, Lomberk G, Cao S, Yaqoob U, Mathison A, Simonetto DA, Huebert RC, Urrutia RA, Shah VH. New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. J Biol Chem. 2014 May 30;289(22):15798-809. PMCID: PMC4140934
18. Calvo E, Grzenda A, Lomberk G, Mathison A, Iovanna J, Urrutia R. Single and combinatorial chromatin coupling events underlies the function of transcript factor Kr??ppel-like factor 11 in the regulation of gene networks. BMC Mol Biol. 2014 May 25;15:10. PMCID: PMC4049485
19. Escande C, Nin V, Pirtskhalava T, Chini CC, Thereza Barbosa M, Mathison A, Urrutia R, Tchkonia T, Kirkland JL, Chini EN. Deleted in Breast Cancer 1 regulates cellular senescence during obesity. Aging Cell. 2014 Oct;13(5):951-3. PMCID: PMC4172532
20. Loft A, Forss I, Siersb?|k MS, Schmidt SF, Larsen AS, Madsen JG, Pisani DF, Nielsen R, Aagaard MM, Mathison A, Neville MJ, Urrutia R, Karpe F, Amri EZ, Mandrup S. Browning of human adipocytes requires KLF11 and reprogramming of PPARI? superenhancers. Genes Dev. 2015 Jan 01;29(1):7-22. PMCID: PMC4281566
21. Leonard PH, Grzenda A, Mathison A, Morbeck DE, Fredrickson JR, de Assuncao TM, Christensen T, Salisbury J, Calvo E, Iovanna J, Coddington CC, Urrutia R, Lomberk G. The Aurora A-HP1I? pathway regulates gene expression and mitosis in cells from the sperm lineage. BMC Dev Biol. 2015 May 29;15:23. PMCID: PMC4448908
22. Mathison A, Escande C, Calvo E, Seo S, White T, Salmonson A, Faubion WA Jr, Buttar N, Iovanna J, Lomberk G, Chini EN, Urrutia R. Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes. Endocrinology. 2015 Oct;156(10):3581-95. PMCID: PMC4588811
23. Guo Y, Fan Y, Zhang J, Lomberk GA, Zhou Z, Sun L, Mathison AJ, Garcia-Barrio MT, Zhang J, Zeng L, Li L, Pennathur S, Willer CJ, Rader DJ, Urrutia R, Chen YE. Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production. J Clin Invest. 2015 Oct 01;125(10):3819-30. PMCID: PMC4607137
24. Campoy EM, Laurito SR, Branham MT, Urrutia G, Mathison A, Gago F, Orozco J, Urrutia R, Mayorga LS, Roqu?? M. Asymmetric Cancer Hallmarks in Breast Tumors on Different Sides of the Body. PLoS One. 2016;11(7):e0157416. PMCID: PMC4934783
25. Sarmento OF, Svingen PA, Xiong Y, Sun Z, Bamidele AO, Mathison AJ, Smyrk TC, Nair AA, Gonzalez MM, Sagstetter MR, Baheti S, McGovern DP, Friton JJ, Papadakis KA, Gautam G, Xavier RJ, Urrutia RA, Faubion WA. The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD). J Biol Chem. 2017 Jan 13;292(2):706-722. PMCID: PMC5241744
26. Mathison A, Salmonson A, Missfeldt M, Bintz J, Williams M, Kossak S, Nair A, de Assuncao TM, Christensen T, Buttar N, Iovanna J, Huebert R, Lomberk G. Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe. Mol Cancer Res. 2017 08;15(8):984-997. PMCID: PMC5705946
27. Cousin MA, Zimmermann MT, Mathison AJ, Blackburn PR, Boczek NJ, Oliver GR, Lomberk GA, Urrutia RA, Deyle DR, Klee EW. Functional validation reveals the novel missense V419L variant in <i>TGFBR2</i> associated with Loeys-Dietz syndrome (LDS) impairs canonical TGF-I? signaling. Cold Spring Harb Mol Case Stud. 2017 07;3(4). PMCID: PMC5495030
28. Lomberk G, Blum Y, Nicolle R, Nair A, Gaonkar KS, Marisa L, Mathison A, Sun Z, Yan H, Elarouci N, Armenoult L, Ayadi M, Ordog T, Lee JH, Oliver G, Klee E, Moutardier V, Gayet O, Bian B, Duconseil P, Gilabert M, Bigonnet M, Garcia S, Turrini O, Delpero JR, Giovannini M, Grandval P, Gasmi M, Secq V, De Reyni??s A, Dusetti N, Iovanna J, Urrutia R. Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes. Nat Commun. 2018 05 17;9(1):1978. PMCID: PMC5958058
29. Seo S, Mathison A, Grzenda A, Podratz J, Calvo E, Brimijoin S, Windebank A, Iovanna J, Lomberk G, Urrutia R. Mechanisms Underlying the Regulation of HP1I? by the NGF-PKA Signaling Pathway. Sci Rep. 2018 10 10;8(1):15077. PMCID: PMC6180112
30. Martin-Mateos R, De Assuncao TM, Arab JP, Jalan-Sakrikar N, Yaqoob U, Greuter T, Verma VK, Mathison AJ, Cao S, Lomberk G, Mathurin P, Urrutia R, Huebert RC, Shah VH. Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-I? Dependent Hepatic Stellate Cell Activation and Liver Fibrosis. Cell Mol Gastroenterol Hepatol. 2019;7(1):197-209. PMCID: PMC6282644
31. Williams MM, Mathison AJ, Christensen T, Greipp PT, Knutson DL, Klee EW, Zimmermann MT, Iovanna J, Lomberk GA, Urrutia RA. Aurora kinase B-phosphorylated HP1I? functions in chromosomal instability. Cell Cycle. 2019 06;18(12):1407-1421. PMCID: PMC6592258
32. He C, Danes JM, Hart PC, Zhu Y, Huang Y, de Abreu AL, O'Brien J, Mathison AJ, Tang B, Frasor JM, Wakefield LM, Ganini D, Stauder E, Zielonka J, Gantner BN, Urrutia RA, Gius D, Bonini MG. SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer. Proc Natl Acad Sci U S A. 2019 11 19;116(47):23534-23541. PMCID: PMC6876149
33. Urrutia G, Salmonson A, Toro-Zapata J, de Assuncao TM, Mathison A, Dusetti N, Iovanna J, Urrutia R, Lomberk G. Combined Targeting of G9a and Checkpoint Kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse. Mol Cancer Res. 2020 03;18(3):448-462. PMCID: PMC7056528
34. Mathison A, Milech De Assuncao T, Dsouza NR, Williams M, Zimmermann MT, Urrutia R, Lomberk G. Discovery, expression, cellular localization, and molecular properties of a novel, alternative spliced HP1I? isoform, lacking the chromoshadow domain. PLoS One. 2020;15(2):e0217452. PMCID: PMC7004349
35. Danes JM, de Abreu ALP, Kerketta R, Huang Y, Palma FR, Gantner BN, Mathison AJ, Urrutia RA, Bonini MG. Inorganic arsenic promotes luminal to basal transition and metastasis of breast cancer. FASEB J. 2020 12;34(12):16034-16048. PMCID: PMC8289339
36. Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Basel DG, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R. Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction. Orphanet J Rare Dis. 2021 02 05;16(1):66. PMCID: PMC7866879
37. Zimmermann MT, Mathison AJ, Stodola T, Evans DB, Abrudan JL, Demos W, Tschannen M, Aldakkak M, Geurts J, Lomberk G, Tsai S, Urrutia R. Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level. Front Oncol. 2021;11:606820. PMCID: PMC7973372
38. Stabenau KA, Zimmermann MT, Mathison A, Zeighami A, Samuels TL, Chun RH, Papsin BC, McCormick ME, Johnston N, Kerschner JE. RNA Sequencing and Pathways Analyses of Middle Ear Epithelia From Patients With Otitis Media. Laryngoscope. 2021 11;131(11):2590-2597.
39. Gonzalez MM, Bamidele AO, Svingen PA, Sagstetter MR, Smyrk TC, Gaballa JM, Hamdan FH, Kosinsky RL, Gibbons HR, Sun Z, Ye Z, Nair A, Ramos GP, Braga Neto MB, Wixom AQ, Mathison AJ, Johnsen SA, Urrutia R, Faubion WA Jr. BMI1 maintains the Treg epigenomic landscape to prevent inflammatory bowel disease. J Clin Invest. 2021 06 15;131(12). PMCID: PMC8203461
40. Urrutia G, de Assuncao TM, Mathison AJ, Salmonson A, Kerketta R, Zeighami A, Stodola TJ, Adsay V, Pehlivanoglu B, Dwinell MB, Zimmermann MT, Iovanna JL, Urrutia R, Lomberk G. Inactivation of the Euchromatic Histone-Lysine <i>N</i>-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks. Front Cell Dev Biol. 2021;9:681153. PMCID: PMC8261250
41. Kim J, Zimmerman MA, Shin WY, Boettcher BT, Lee JS, Park JI, Ali M, Yang M, Mishra J, Hagen CE, McGraw JE, Mathison A, Woehlck HJ, Lomberk G, Camara AKS, Urrutia RA, Stowe DF, Hong JC. Effects of Subnormothermic Regulated Hepatic Reperfusion on Mitochondrial and Transcriptomic Profiles in a Porcine Model. Ann Surg. 2021 Aug 13. PMCID: PMC8840998
42. Stodola TJ, Chi YI, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R. Computational modeling reveals key molecular properties and dynamic behavior of disruptor of telomeric silencing 1-like (DOT1L) and partnering complexes involved in leukemogenesis. Proteins. 2022 01;90(1):282-298. PMCID: PMC8671179
43. Mathison AJ, Kerketta R, de Assuncao TM, Leverence E, Zeighami A, Urrutia G, Stodola TJ, di Magliano MP, Iovanna JL, Zimmermann MT, Lomberk G, Urrutia R. Kras<sup>G12D</sup> induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells. Genome Biol. 2021 10 14;22(1):289. PMCID: PMC8518179
44. Tripathi S, Dsouza NR, Mathison AJ, Leverence E, Urrutia R, Zimmermann MT. Enhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics Computational and Structural Biotechnology Journal. January 2022;20:117-127.
45. Allison RL, Adelman JW, Abrudan J, Urrutia RA, Zimmermann MT, Mathison AJ, Ebert AD. Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons Genes. February 2022;13(2).
46. Allison RL, Adelman JW, Abrudan J, Urrutia RA, Zimmermann MT, Mathison AJ, Ebert AD. Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons. Genes (Basel). 2022 01 27;13(2). PMCID: PMC8871895
47. Stabenau KA, Samuels TL, Lam TK, Mathison AJ, Wells C, Altman KW, Battle MA, Johnston N. Pepsinogen/Proton Pump Co-Expression in Barrett's Esophageal Cells Induces Cancer-Associated Changes. Laryngoscope. 2022 Mar 22.
48. Fang S, Wu J, Reho JJ, Lu KT, Brozoski DT, Kumar G, Werthman AM, Silva SD Jr, Muskus Veitia PC, Wackman KK, Mathison AJ, Teng BQ, Lin CW, Quelle FW, Sigmund CD. RhoBTB1 reverses established arterial stiffness in angiotensin II-induced hypertension by promoting actin depolymerization. JCI Insight. 2022 05 09;7(9). PMCID: PMC9090250
49. Xie Y, Nishijima Y, Zinkevich NS, Korishettar A, Fang J, Mathison AJ, Zimmermann MT, Wilcox DA, Gutterman DD, Shen Y, Zhang DX. NADPH oxidase 4 contributes to TRPV4-mediated endothelium-dependent vasodilation in human arterioles by regulating protein phosphorylation of TRPV4 channels. Basic Res Cardiol. 2022 04 25;117(1):24. PMCID: PMC9119129
50. Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R. Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers. Comput Struct Biotechnol J. 2022;20:2200-2211. PMCID: PMC9111933
51. Fang S, Wu J, Reho J, Lu KT, Brozoski D, Werthman A, Kumar G, Silva SD, Muskus P, Wackman K, Mathison A, Urrutia RA, Teng BQ, Lin CW, Quelle FW, Sigmund CD. Rho-related BTB Domain-containing Protein 1 Reverses Established Arterial Stiffness in Angiotensin II-treated Mice. FASEB J. 2022 May;36 Suppl 1.
52. Urrutia G, Abrudan JL, Du M, de Assuncao TM, Mathison AJ, Zimmermann MT, Lomberk G, Urrutia R. To ChIP, or to CUT, that is the question: Comparative Evaluation of NextGen Methodologies for Studying the genome-wide distribution of Histone H3 Lysine 9 di-methyl mark in pancreatic cells. FASEB J. 2022 May;36 Suppl 1.
53. Urrutia R, Salmonson A, Urrutia G, de Assuncao TM, Zimmermann MT, Mathison AJ, Lomberk G. Transcriptional Landscape Established by the Euchromatic Histone-lysine N-methyltransferase Pathway During Pancreas Ontogenesis and Pancreatitis. FASEB J. 2022 May;36 Suppl 1.
54. Chi YI, Stodola TJ, de Assuncao TM, Volkman B, Smith B, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R. Defining the Mutational Landscape That Affects the Histone Demethylase KDM6A/UTX in Human Cancer. FASEB J. 2022 May;36 Suppl 1.
55. Du M, Abrudan JL, Urrutia G, de Assuncao TM, Mathison AJ, Zimmermann MT, Lomberk G, Urrutia R. Epigenomic mechanisms used by KrasG12D to regulate inflammatory gene clusters in epithelial pancreatic cancer cells, which are critical for reprogramming the tumor microenvironment. FASEB J. 2022 May;36 Suppl 1.
56. Jorge SD, Chi YI, de Assuncao TM, Mathison AJ, Volkman B, Smith B, Lomberk G, Zimmermann MT, Urrutia R. Integrative Modeling, Molecular Mechanics, and Molecular Dynamics Evaluation of Genomics Variants in KMT2C (MLL3), a Gene Involved in Kleefstra Syndrome Type 2. FASEB J. 2022 May;36 Suppl 1.
57. Stancill JS, Hansen PA, Mathison AJ, Schmidt EE, Corbett JA. Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs I?-Cell Function. Function (Oxf). 2022;3(4):zqac034. PMCID: PMC9301323
 
Abstracts
1. Great Lakes Regional Center of Excellence Meeting, Zion, IL. November 2004. A Mathison, L Eskra, G Splitter. Macrophage transcript levels altered by Brucella infection reveal host mechanisms specific to pathogenic B. melitensis.
2. Immunology Research Symposium, Madison, WI. June 2006. A Mathison, L Eskra, G Splitter. Macrophage transcript levels altered by Brucella infection reveal host mechanisms specific to pathogenic B. melitensis.
3. American Pancreatic Association Annual Meeting, 2008. G Lomberk, S Ilyas, A Mathison, J Bonilla, A Conde Perez, Demars, N Buttar, and R Urrutia. KLF11 complexes with the epigenetic gene silencer protein, HP1 to mediate tumor suppressor activities.
4. European Pancreatic Club Meeting, 2009. G. Lomberk, A Mathison, M Fernandez-Zapico, S Ilyas, C Demars, N Buttar, R Urrutia. KLF11 complexes with the epigenetic gene silencer protein, HP1 to mediate its tumor suppressor activities
5. American Pancreatic Association Annual Meeting, 2009. A Liebl, A Mathison, J Bharrucha, V Shah, G Lomberk, R Urrutia. Generation of human, mouse, and rat pancreatic stellate cell lines for studying transcriptional control of extra cellular matrix synthesis
6. American Pancreatic Association Annual Meeting, 2009. A Mathison, A Liebl, V Shah, G Lomberk and R Urrutia. Role of the KLF11-MMP pathway in stellate cell biology and tumor suppression.
7. Digestive Disease Week Meeting, 2010. C Virk, A Mathison, C DeMars, U Shergill, G Lomberk S Sodavarapu, M Fernandez-Zapico, U Yaqoob, V Shah, R Urrutia, N Buttar. Distinct Stellate Cell Response to Injury in KLF11 Knockout Mice: Implications in Repair and Organ Dysfunction.
8. American Pancreatic Association Annual Meeting, 2010. A Mathison, A Liebl, CJ DeMars, U Shergill, G Lomberk, V Shah, N Buttar and R Urrutia. Novel Tumor Suppresor Pathway in Pancreatic Cancer Derived from Selective Remodeling of Desmoplasia.
9. American Pancreatic Association Annual Meeting, 2011. A Mathison, A Liebl, J Bharrucha, V Shah, G Lomberk, R Urrutia. Epigenetics in GI Organ Fibrosis: Generation of Mouse and Rat Pancreatic Stellate Cell Lines for Studying Epigenetic Control of Extracellular Matrix Synthesis
10. American Pancreatic Association Annual Meeting, 2011. A Mathison, A Liebl, G Lomberk, CJ DeMars, U Shergill, V Shah, N Buttar, R Urrutia. Epigenetics in GI Organ Fibrosis: A KLF11-HDAC Mediated Pathway is Anti-fibrogenic in Liver and Pancreas.
11. American Pancreatic Association Annual Meeting, 2013. G Lomberk, A Mathison, and R Urrutia. Epigenetic Signaling by HP1 Regulates KRAS-Induced Growth Promoting Gene Networks in Pancreatic Cancer Cells.
12. American Pancreatic Association Annual Meeting, 2013. A Mathison, M Fernandez- Zapico, R Urrutia and G Lomberk. Preclinical Testing of a New Combinatorial Therapy Against Aurora A and G9a for the Treatment of Pancreatic Cancer.
13. Midwest Chromatin and Epigenetics Meeting, 2014. Differential Regulation of HP1 Isoforms by Aurora Kinases during Mitosis. M Williams, A Mathison, G Lomberk and R Urrutia.
14. American Pancreatic Association Annual Meeting, 2014. HP1-Histone Methyl Transferase Pathways Relay Epigenetic Signals Downstream of the Pancreatic Oncogenes, Aurora Kinases. M Williams, A Mathison, G Lomberk and R Urrutia.
15. American Pancreatic Association Annual Meeting, 2014. Inactivation of the AurkA-HP1I?-G9a Pathway Synergistically Inhibits PDAC Cell Growth by Triggering Cell Death via Mitotic Catastrophe. A Mathison, M Williams, R Urrutia, G Lomberk.
16. American Association for Cancer Research, 2017. Pharmacological targeting of the Aurora A and Histone 3 lysine 9 methyltransferase pathways in pancreatic cancer induces mitotic catastrophe. A. Mathison, A. Salmonson, M. Missfeldt, T. de Assuncao, J. Bintz, T. Christensen, S. Kossak, A. Nair, J. Iovanna, R. Huebert, G. Lomberk.
17. American Association for Cancer Research, 2017. The epigenetic regulator, G9a, is a KRAS-inducible protein and its inactivation inhibits PanIN formation by this oncogene. A. Mathison, A. Salmonson, B. Paradise, M. Missfeldt, J. Iovanna, D. Billadeau, R. Urrutia, G. Lomberk.
18. Academic Surgical Congress, 2019. The Early Epigenomic Landscape of Oncogenic KRAS Signaling. R. Kerketta, A. Mathison, A. Zeighami, J. Abrudan, W. Demos, M. Zimmermann, G. Lomberk, R. Urrutia.
19. American Association for Cancer Research, 2019. Genomic variation in PDAC-predisposing genes identified using the MCW germline exome panel. J Abrudan, S Tsai, W Demos, M.T. Zimmermann, M Tschannen, J Geurts, A Mathison, G Lomberk, D Evans, R Urrutia.
20. American Society of Human Genetics, 2020. Interpreting the wide genomic variation in PDAC predisposing genes. A. Mathison, M.T. Zimmermann, J.L. Abrudan, T. Stodola, W. Demos, M. Tschannen, M. Aldakkak, J. Geurts, S. Tsai, G. Lomberk, D. Evans, and R. Urrutia. Poster Presentation.