CURRICULUM VITAE
Angela Mathison PhD
Angela Mathison PhD
Assistant Professor
Department of Surgery
Division of Administration
Department of Surgery
Division of Administration
OFFICE ADDRESS: |
Translational and Biomedical Research Center |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
01/01/2008 - 07/01/2017 Sr. Research Technologist, Gastroenterology Unit, Mayo Clinic, Rochester, MN |
FACULTY APPOINTMENTS: |
08/2018 - Present Assistant Professor, Department of Surgery, Division of Research, The Medical College of Wisconsin, Milwaukee, WI |
ADMINISTRATIVE APPOINTMENTS: |
07/2017 - Present Director of 'Omics Research and Development, Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI |
02/01/2024 - Present Member Institutional Biosafety Committee, Medical College of Wisconsin, Milwaukee, WI |
EDUCATIONAL ADMINISTRATIVE APPOINTMENTS: |
09/01/2024 - Present "Multiomic Technology for Precision Medicine" Course Developer and Director, Institute for Health & Equity, Precision Medicine Education Program (PM Ed), Medical College of Wisconsin, Milwaukee, WI |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
01/2024 - Present Association of Biomolecular Resource Facilities (Member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Journal Review |
09/01/2022 - Present American Journal of Perinatology |
09/15/2022 - Present Frontiers in Oncology |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
01/01/2023 - Present Grant Reviewer, CTSA External Reviewers Exchange Consortium, Clinical and Translational Science Awards Program |
05/2023 - Present Grant Reviewer, CTSI-Mellowes Center RFA, Clinical and Translational Science Institute |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
National |
A Mathison, L Eskra, G Splitter, Macrophage transcript levels altered by Brucella infection reveal host mechanisms specific to pathogenic B. melitensis, 57th Annual Brucellosis Research Conference, Chicago, IL, 11/2004 |
A Mathison, J Harms, L Eskra, G Splitter, Alteration of the Fc gamma Receptor I in murine macrophages during a Brucella species infection, 59th Annual Brucellosis Research Conference, Chicago, IL, 12/2006 |
A Mathison, G Lomberk, JS Zhang, A Conde Perez, L Miller, and R Urrutia, The Gbeta subunit of heterotrimeric G proteins links pancreatic GPCR activation to long term responses, American Pancreatic Association Annual Meeting, Chicago, IL, 11/2008 |
G Lomberk, A Mathison, and R Urrutia, Epigenetic Regulation Downstream of KRAS by the HP1-Histone Methyl Transferase Pathway Mediates Pancreatic Cancer Growth, American Pancreatic Association Annual Meeting, Kohala Coast, HI, 11/2014 |
MCW TEACHING ACTIVITIES: |
Graduate Student Education |
01/2018 - Present Next Generation Sequencing Lecture once per year for Functional Genomics Course |
09/2020 - Present Transcriptomic and Next Generation Sequencing Lecture once per year for Techniques in Molecular and Cellular Biology Course |
02/2022 - Present Next Generation Sequencing and Precision Medicine Lecture once per year for the Institute for Health & Equity |
09/2024 - Present Multiomic Technologies for Precision Medicine Course design and lectures for Precision Medicine Education Program |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Undergraduate Students |
06/2013 - 08/2013 Raghav Chandra, Research, Undergraduate Research Employment Program (UREP) |
06/2013 - 08/2013 Nausheen Singh, Research, Undergraduate Research Employment Program (UREP) |
06/2013 - 08/2013 Nalini Singh, Research, Undergraduate Research Employment Program (UREP) |
06/2014 - 08/2014 Irina Horwath, Research, Summer Undergraduate Research Fellowship (SURF) |
06/2014 - 08/2014 Ishtpreet Singh, Research, Summer Undergraduate Research Fellowship (SURF) |
06/2014 - 08/2014 Kelly Aukes, Research, Summer Undergraduate Research Fellowship (SURF) |
08/2017 - 12/2017 Elise Sloey, Research, Program for Undergraduate Research Experience (PURE) |
06/2021 - 08/2021 Charles Met, Research, Summer Program for Undergraduate Research (SPUR) |
08/2022 - 12/2022 Matthew Diaz, Research, Program for Undergraduate Research Experience (PURE) |
06/2023 - 08/2023 Maia Samuelson, Research, 500 Stars Research Experience |
06/2023 - 08/2023 Riya Singh, Research, 500 Stars Research Experience |
06/2023 Riya Tanwar, Research, 500 Stars Research Experience |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Strack A, Duffy CF, Malvey M, Arriaga EA. Individual mitochondrion characterization: a comparison of classical assays to capillary electrophoresis with laser-induced fluorescence detection. Anal Biochem. PubMed PMID: 11444809. |
2. Eskra L, Mathison A, Splitter G. Microarray analysis of mRNA levels from RAW264.7 macrophages infected with Brucella abortus. Infect Immun. 2003 Mar;71(3):1125-33. PMCID: PMC148819 |
3. Rajashekara G, Krepps M, Eskra L, Mathison A, Montgomery A, Ishii Y, Splitter G. Unraveling Brucella genomics and pathogenesis in immunocompromised IRF-1-/- mice. Am J Reprod Immunol. 2005 Dec;54(6):358-68. |
4. Rajashekara G, Eskra L, Mathison A, Petersen E, Yu Q, Harms J, Splitter G. Brucella: functional genomics and host-pathogen interactions. Anim Health Res Rev. 2006;7(1-2):1-11. |
5. Lomberk G, Mathison AJ, Grzenda A, Urrutia R. The sunset of somatic genetics and the dawn of epigenetics: a new frontier in pancreatic cancer research. Curr Opin Gastroenterol. 2008 Sep;24(5):597-602. PMCID: PMC2941574 |
6. Covert J, Mathison AJ, Eskra L, Banai M, Splitter G. Brucella melitensis, B. neotomae and B. ovis elicit common and distinctive macrophage defense transcriptional responses. Exp Biol Med (Maywood). 2009 Dec;234(12):1450-67. PMCID: PMC2880867 |
7. Mathison A, Liebl A, Bharucha J, Mukhopadhyay D, Lomberk G, Shah V, Urrutia R. Pancreatic stellate cell models for transcriptional studies of desmoplasia-associated genes. Pancreatology. 2010;10(4):505-16. PMCID: PMC3214918 |
8. Daftary GS, Lomberk GA, Buttar NS, Allen TW, Grzenda A, Zhang J, Zheng Y, Mathison AJ, Gada RP, Calvo E, Iovanna JL, Billadeau DD, Prendergast FG, Urrutia R. Detailed structural-functional analysis of the Krüppel-like factor 16 (KLF16) transcription factor reveals novel mechanisms for silencing Sp/KLF sites involved in metabolism and endocrinology. J Biol Chem. 2012 Mar 02;287(10):7010-25. PMCID: PMC3293586 |
9. Seo S, Lomberk G, Mathison A, Buttar N, Podratz J, Calvo E, Iovanna J, Brimijoin S, Windebank A, Urrutia R. Krüppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells. J Biol Chem. 2012 Apr 13;287(16):12723-35. PMCID: PMC3339994 |
10. Lomberk G, Mathison AJ, Grzenda A, Seo S, DeMars CJ, Ilyas SI, Bonilla-Velez J, Calvo E, Fernandez-Zapico ME, Iovanna J, Buttar NS, Urrutia R. Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases. J Biol Chem. 2012 Apr 13;287(16):13026-39. PMCID: PMC3339955 |
11. Grzenda A, Lomberk G, Svingen P, Mathison A, Calvo E, Iovanna J, Xiong Y, Faubion W, Urrutia R. Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression. Epigenetics Chromatin. 2013 Feb 28;6(1):3. PMCID: PMC3606351 |
12. Daftary GS, Zheng Y, Tabbaa ZM, Schoolmeester JK, Gada RP, Grzenda AL, Mathison AJ, Keeney GL, Lomberk GA, Urrutia R. A novel role of the Sp/KLF transcription factor KLF11 in arresting progression of endometriosis. PLoS One. 2013;8(3):e60165. PMCID: PMC3610699 |
13. Lomberk G, Grzenda A, Mathison A, Escande C, Zhang JS, Calvo E, Miller LJ, Iovanna J, Chini EN, Fernandez-Zapico ME, Urrutia R. Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young. J Biol Chem. 2013 Jun 14;288(24):17745-58. PMCID: PMC3682574 |
14. Grzenda A, Leonard P, Seo S, Mathison AJ, Urrutia G, Calvo E, Iovanna J, Urrutia R, Lomberk G. Functional impact of Aurora A-mediated phosphorylation of HP1γ at serine 83 during cell cycle progression. Epigenetics Chromatin. 2013 Jul 05;6(1):21. PMCID: PMC3707784 |
15. Mathison A, Grzenda A, Lomberk G, Velez G, Buttar N, Tietz P, Hendrickson H, Liebl A, Xiong YY, Gores G, Fernandez-Zapico M, Larusso NF, Faubion W, Shah VH, Urrutia R. Role for Krüppel-like transcription factor 11 in mesenchymal cell function and fibrosis. PLoS One. 2013;8(9):e75311. PMCID: PMC3775729 |
16. Hayashi Y, Asuzu DT, Gibbons SJ, Aarsvold KH, Bardsley MR, Lomberk GA, Mathison AJ, Kendrick ML, Shen KR, Taguchi T, Gupta A, Rubin BP, Fletcher JA, Farrugia G, Urrutia RA, Ordog T. Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways. PLoS One. 2013;8(10):e76822. PMCID: PMC3792098 |
17. Calvo E, Grzenda A, Lomberk G, Mathison A, Iovanna J, Urrutia R. Single and combinatorial chromatin coupling events underlies the function of transcript factor Krüppel-like factor 11 in the regulation of gene networks. BMC Mol Biol. 2014 May 25;15:10. PMCID: PMC4049485 |
18. de Assuncao TM, Lomberk G, Cao S, Yaqoob U, Mathison A, Simonetto DA, Huebert RC, Urrutia RA, Shah VH. New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. J Biol Chem. 2014 May 30;289(22):15798-809. PMCID: PMC4140934 |
19. Escande C, Nin V, Pirtskhalava T, Chini CC, Thereza Barbosa M, Mathison A, Urrutia R, Tchkonia T, Kirkland JL, Chini EN. Deleted in Breast Cancer 1 regulates cellular senescence during obesity. Aging Cell. 2014 Oct;13(5):951-3. PMCID: PMC4172532 |
20. Loft A, Forss I, Siersbæk MS, Schmidt SF, Larsen AS, Madsen JG, Pisani DF, Nielsen R, Aagaard MM, Mathison A, Neville MJ, Urrutia R, Karpe F, Amri EZ, Mandrup S. Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers. Genes Dev. 2015 Jan 01;29(1):7-22. PMCID: PMC4281566 |
21. Leonard PH, Grzenda A, Mathison A, Morbeck DE, Fredrickson JR, de Assuncao TM, Christensen T, Salisbury J, Calvo E, Iovanna J, Coddington CC, Urrutia R, Lomberk G. The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage. BMC Dev Biol. 2015 May 29;15:23. PMCID: PMC4448908 |
22. Guo Y, Fan Y, Zhang J, Lomberk GA, Zhou Z, Sun L, Mathison AJ, Garcia-Barrio MT, Zhang J, Zeng L, Li L, Pennathur S, Willer CJ, Rader DJ, Urrutia R, Chen YE. Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production. J Clin Invest. 2015 Oct 01;125(10):3819-30. PMCID: PMC4607137 |
23. Mathison A, Escande C, Calvo E, Seo S, White T, Salmonson A, Faubion WA Jr, Buttar N, Iovanna J, Lomberk G, Chini EN, Urrutia R. Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes. Endocrinology. 2015 Oct;156(10):3581-95. PMCID: PMC4588811 |
24. Campoy EM, Laurito SR, Branham MT, Urrutia G, Mathison A, Gago F, Orozco J, Urrutia R, Mayorga LS, Roqué M. Asymmetric Cancer Hallmarks in Breast Tumors on Different Sides of the Body. PLoS One. 2016;11(7):e0157416. PMCID: PMC4934783 |
25. Sarmento OF, Svingen PA, Xiong Y, Sun Z, Bamidele AO, Mathison AJ, Smyrk TC, Nair AA, Gonzalez MM, Sagstetter MR, Baheti S, McGovern DP, Friton JJ, Papadakis KA, Gautam G, Xavier RJ, Urrutia RA, Faubion WA. The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD). J Biol Chem. 2017 Jan 13;292(2):706-722. PMCID: PMC5241744 |
26. Cousin MA, Zimmermann MT, Mathison AJ, Blackburn PR, Boczek NJ, Oliver GR, Lomberk GA, Urrutia RA, Deyle DR, Klee EW. Functional validation reveals the novel missense V419L variant in <i>TGFBR2</i> associated with Loeys-Dietz syndrome (LDS) impairs canonical TGF-β signaling. Cold Spring Harb Mol Case Stud. 2017 Jul;3(4). PMCID: PMC5495030 |
27. Mathison A, Salmonson A, Missfeldt M, Bintz J, Williams M, Kossak S, Nair A, de Assuncao TM, Christensen T, Buttar N, Iovanna J, Huebert R, Lomberk G. Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe. Mol Cancer Res. 2017 Aug;15(8):984-997. PMCID: PMC5705946 |
28. Lomberk G, Blum Y, Nicolle R, Nair A, Gaonkar KS, Marisa L, Mathison A, Sun Z, Yan H, Elarouci N, Armenoult L, Ayadi M, Ordog T, Lee JH, Oliver G, Klee E, Moutardier V, Gayet O, Bian B, Duconseil P, Gilabert M, Bigonnet M, Garcia S, Turrini O, Delpero JR, Giovannini M, Grandval P, Gasmi M, Secq V, De Reyniès A, Dusetti N, Iovanna J, Urrutia R. Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes. Nat Commun. 2018 May 17;9(1):1978. PMCID: PMC5958058 |
29. Seo S, Mathison A, Grzenda A, Podratz J, Calvo E, Brimijoin S, Windebank A, Iovanna J, Lomberk G, Urrutia R. Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway. Sci Rep. 2018 Oct 10;8(1):15077. PMCID: PMC6180112 |
30. Martin-Mateos R, De Assuncao TM, Arab JP, Jalan-Sakrikar N, Yaqoob U, Greuter T, Verma VK, Mathison AJ, Cao S, Lomberk G, Mathurin P, Urrutia R, Huebert RC, Shah VH. Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis. Cell Mol Gastroenterol Hepatol. 2019;7(1):197-209. PMCID: PMC6282644 |
31. Williams MM, Mathison AJ, Christensen T, Greipp PT, Knutson DL, Klee EW, Zimmermann MT, Iovanna J, Lomberk GA, Urrutia RA. Aurora kinase B-phosphorylated HP1α functions in chromosomal instability. Cell Cycle. 2019 Jun;18(12):1407-1421. PMCID: PMC6592258 |
32. He C, Danes JM, Hart PC, Zhu Y, Huang Y, de Abreu AL, O'Brien J, Mathison AJ, Tang B, Frasor JM, Wakefield LM, Ganini D, Stauder E, Zielonka J, Gantner BN, Urrutia RA, Gius D, Bonini MG. SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23534-23541. PMCID: PMC6876149 |
33. Mathison A, Milech De Assuncao T, Dsouza NR, Williams M, Zimmermann MT, Urrutia R, Lomberk G. Discovery, expression, cellular localization, and molecular properties of a novel, alternative spliced HP1γ isoform, lacking the chromoshadow domain. PLoS One. 2020;15(2):e0217452. PMCID: PMC7004349 |
34. Urrutia G, Salmonson A, Toro-Zapata J, de Assuncao TM, Mathison A, Dusetti N, Iovanna J, Urrutia R, Lomberk G. Combined Targeting of G9a and Checkpoint Kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse. Mol Cancer Res. 2020 Mar;18(3):448-462. PMCID: PMC7056528 |
35. Danes JM, de Abreu ALP, Kerketta R, Huang Y, Palma FR, Gantner BN, Mathison AJ, Urrutia RA, Bonini MG. Inorganic arsenic promotes luminal to basal transition and metastasis of breast cancer. FASEB J. 2020 Dec;34(12):16034-16048. PMCID: PMC8289339 |
36. Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Basel DG, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R. Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction. Orphanet J Rare Dis. 2021 Feb 05;16(1):66. PMCID: PMC7866879 |
37. Zimmermann MT, Mathison AJ, Stodola T, Evans DB, Abrudan JL, Demos W, Tschannen M, Aldakkak M, Geurts J, Lomberk G, Tsai S, Urrutia R. Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level. Front Oncol. 2021;11:606820. PMCID: PMC7973372 |
38. Gonzalez MM, Bamidele AO, Svingen PA, Sagstetter MR, Smyrk TC, Gaballa JM, Hamdan FH, Kosinsky RL, Gibbons HR, Sun Z, Ye Z, Nair A, Ramos GP, Braga Neto MB, Wixom AQ, Mathison AJ, Johnsen SA, Urrutia R, Faubion WA Jr. BMI1 maintains the Treg epigenomic landscape to prevent inflammatory bowel disease. J Clin Invest. 2021 Jun 15;131(12). PMCID: PMC8203461 |
39. Urrutia G, de Assuncao TM, Mathison AJ, Salmonson A, Kerketta R, Zeighami A, Stodola TJ, Adsay V, Pehlivanoglu B, Dwinell MB, Zimmermann MT, Iovanna JL, Urrutia R, Lomberk G. Inactivation of the Euchromatic Histone-Lysine <i>N</i>-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks. Front Cell Dev Biol. 2021;9:681153. PMCID: PMC8261250 |
40. Mathison AJ, Kerketta R, de Assuncao TM, Leverence E, Zeighami A, Urrutia G, Stodola TJ, di Magliano MP, Iovanna JL, Zimmermann MT, Lomberk G, Urrutia R. Kras<sup>G12D</sup> induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells. Genome Biol. 2021 Oct 14;22(1):289. PMCID: PMC8518179 |
41. Stabenau KA, Zimmermann MT, Mathison A, Zeighami A, Samuels TL, Chun RH, Papsin BC, McCormick ME, Johnston N, Kerschner JE. RNA Sequencing and Pathways Analyses of Middle Ear Epithelia From Patients With Otitis Media. Laryngoscope. 2021 Nov;131(11):2590-2597. |
42. Stodola TJ, Chi YI, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R. Computational modeling reveals key molecular properties and dynamic behavior of disruptor of telomeric silencing 1-like (DOT1L) and partnering complexes involved in leukemogenesis. Proteins. 2022 Jan;90(1):282-298. PMCID: PMC8671179 |
43. Tripathi S, Dsouza NR, Mathison AJ, Leverence E, Urrutia R, Zimmermann MT. Enhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics. Comput Struct Biotechnol J. 2022;20:117-127. PMCID: PMC8688876 |
44. Allison RL, Adelman JW, Abrudan J, Urrutia RA, Zimmermann MT, Mathison AJ, Ebert AD. Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons. Genes (Basel). 2022 Jan 27;13(2). PMCID: PMC8871895 |
45. Xie Y, Nishijima Y, Zinkevich NS, Korishettar A, Fang J, Mathison AJ, Zimmermann MT, Wilcox DA, Gutterman DD, Shen Y, Zhang DX. NADPH oxidase 4 contributes to TRPV4-mediated endothelium-dependent vasodilation in human arterioles by regulating protein phosphorylation of TRPV4 channels. Basic Res Cardiol. 2022 Apr 25;117(1):24. PMCID: PMC9119129 |
46. Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R. Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers. Comput Struct Biotechnol J. 2022;20:2200-2211. PMCID: PMC9111933 |
47. Fang S, Wu J, Reho JJ, Lu KT, Brozoski DT, Kumar G, Werthman AM, Silva SD Jr, Muskus Veitia PC, Wackman KK, Mathison AJ, Teng BQ, Lin CW, Quelle FW, Sigmund CD. RhoBTB1 reverses established arterial stiffness in angiotensin II-induced hypertension by promoting actin depolymerization. JCI Insight. 2022 May 09;7(9). PMCID: PMC9090250 |
48. Stancill JS, Hansen PA, Mathison AJ, Schmidt EE, Corbett JA. Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs β-Cell Function. Function (Oxf). 2022;3(4):zqac034. PMCID: PMC9301323 |
49. Stabenau KA, Samuels TL, Lam TK, Mathison AJ, Wells C, Altman KW, Battle MA, Johnston N. Pepsinogen/Proton Pump Co-Expression in Barrett's Esophageal Cells Induces Cancer-Associated Changes. Laryngoscope. 2023 Jan;133(1):59-69. |
50. Han L, Wu Y, Fang K, Sweeney S, Roesner UK, Parrish M, Patel K, Walter T, Piermattei J, Trimboli A, Lefler J, Timmers CD, Yu XZ, Jin VX, Zimmermann MT, Mathison AJ, Urrutia R, Ostrowski MC, Leone G. The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis. Nat Commun. 2023 Jan 03;14(1):1. PMCID: PMC9810714 |
51. Kim J, Zimmerman MA, Shin WY, Boettcher BT, Lee JS, Park JI, Ali M, Yang M, Mishra J, Hagen CE, McGraw JE, Mathison A, Woehlck HJ, Lomberk G, Camara AKS, Urrutia RA, Stowe DF, Hong JC. Effects of Subnormothermic Regulated Hepatic Reperfusion on Mitochondrial and Transcriptomic Profiles in a Porcine Model. Ann Surg. 2023 Feb 01;277(2):e366-e375. PMCID: PMC8840998 |
52. Ratnasinghe BD, Haque N, Wagenknecht JB, Jensen DR, Valdivia Esparza GK, Leverence EN, Milech De Assuncao T, Mathison AJ, Lomberk G, Smith BC, Volkman BF, Urrutia R, Zimmermann MT. Beyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape. Comput Struct Biotechnol J. 2023;21:4790-4803. PMCID: PMC10570560 |
53. Kleman A, Singavi A, Pommert L, Mathison AJ, Hari P, Dhakal B, Mohan M, Janz S, Knight JM, Shah MV, Schinke C, Burns R, Steinhardt GF, Rao S, Carlson K. A timeline of genetic variant enrichment: from multiple myeloma diagnosis to myeloma-associated myeloid malignancy. Blood Adv. 2023 Sep 26;7(18):5549-5553. PMCID: PMC10514068 |
54. Chi YI, Jorge SD, Jensen DR, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R. A multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1. Comput Struct Biotechnol J. 2023;21:5249-5258. PMCID: PMC10632586 |
55. Jorge SD, Chi YI, Mazaba JL, Haque N, Wagenknecht J, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R. Deep computational phenotyping of genomic variants impacting the SET domain of KMT2C reveal molecular mechanisms for their dysfunction. Front Genet. 2023;14:1291307. PMCID: PMC10715303 |
56. Pisano MD, Sun F, Cheng Y, Parashar D, Zhou V, Jing X, Sompallae R, Abrudan J, Zimmermann MT, Mathison A, Janz S, Pufall MA. IL6Myc mouse is an immunocompetent model for the development of aggressive multiple myeloma. Haematologica. 2023 Dec 01;108(12):3372-3383. PMCID: PMC10690922 |
57. Zhou W, Lim A, Elmadbouh OHM, Edderkaoui M, Osipov A, Mathison AJ, Urrutia R, Liu T, Wang Q, Pandol SJ. Verteporfin induces lipid peroxidation and ferroptosis in pancreatic cancer cells. Free Radic Biol Med. 2024 Feb 20;212:493-504. PMCID: PMC10906657 |
58. Hall WA, Mathison AJ, DeVoe E, Tschannen M, Wendt-Andrae J, Straza M, Awan M, Puckett LL, Lawton CAF, Schultz C, Urrutia R, Kerns S, Torres-Roca JF, Li XA, Erickson B, Nevalainen MT, Zimmermann MT, Paulson E. Changes in Daily Apparent Diffusion Coefficient on Fully Quantitative Magnetic Resonance Imaging Correlate With Established Genomic Pathways of Radiation Sensitivity and Reveal Novel Biologic Associations. Int J Radiat Oncol Biol Phys. 2024 Oct 01;120(2):570-578. |
59. Kim J, Zimmermann MT, Mathison AJ, Lomberk G, Urrutia R, Hong JC. Transcriptional Profiling Underscores the Role of Preprocurement Allograft Metabolism and Innate Immune Status on Outcomes in Human Liver Transplantation. Ann Surg Open. 2024 Jun;5(2):e444. PMCID: PMC11191965 |
60. Pollin G, Mathison AJ, de Assuncao TM, Thomas A, Zeighami A, Salmonson A, Liu H, Urrutia G, Vankayala P, Pandol SJ, Hong JC, Zimmermann MT, Iovanna J, Jin VX, Urrutia R, Lomberk G. <i>Ehmt2</i> inactivation in pancreatic epithelial cells shapes the transcriptional landscape and inflammation response of the whole pancreas. Front Genet. 2024;15:1412767. PMCID: PMC11211573 |
61. Zenga J, Awan MJ, Frei A, Massey B, Bruening J, Shukla M, Sharma GP, Shreenivas A, Wong SJ, Zimmermann MT, Mathison AJ, Himburg HA. Type I interferon signaling promotes radioresistance in head and neck cancer. Transl Cancer Res. 2024 May 31;13(5):2535-2543. PMCID: PMC11170510 |
62. Zenga J, Himburg HA, Wong SJ, Kearl T, Hematti P, Jin VX, Memon AA, Mathison AJ, Awan MJ. In silico identification of public neo-antigens in head and neck Cancer for T cell receptor Engineering: Targeting PI3KCA and TP53 missense mutations. Oral Oncol. 2024 Sep;156:106947. |
63. Pollin G, Lomberk GA, Mathison AJ, Zimmermann MT, Urrutia R. Mutant KRAS inhibitors enter the scene of precision therapeutics for pancreatic cancer. J Gastrointest Oncol. 2024 Aug 31;15(4):1996-2001. PMCID: PMC11399826 |
64. Ergun P, Samuels TL, Mathison AJ, Plehhova K, Coyle C, Horvath L, Johnston N. Global Transcriptomic Analysis of Topical Sodium Alginate Protection against Peptic Damage in an In Vitro Model of Treatment-Resistant Gastroesophageal Reflux Disease. Int J Mol Sci. 2024 Oct 05;25(19). PMCID: PMC11605242 |
65. Khedr S, Dissanayake LV, Alsheikh AJ, Zietara A, Spires DR, Kerketta R, Mathison AJ, Urrutia R, Palygin O, Staruschenko A. Role of cGAS-STING pathway in aging and sexual dimorphism in diabetic kidney disease. JCI Insight. 2024 Nov 26. |
Abstracts |
1. Great Lakes Regional Center of Excellence Meeting, Zion, IL. November 2004. A Mathison, L Eskra, G Splitter. Macrophage transcript levels altered by Brucella infection reveal host mechanisms specific to pathogenic B. melitensis. |
2. Immunology Research Symposium, Madison, WI. June 2006. A Mathison, L Eskra, G Splitter. Macrophage transcript levels altered by Brucella infection reveal host mechanisms specific to pathogenic B. melitensis. |
3. American Pancreatic Association Annual Meeting, 2008. G Lomberk, S Ilyas, A Mathison, J Bonilla, A Conde Perez, Demars, N Buttar, and R Urrutia. KLF11 complexes with the epigenetic gene silencer protein, HP1 to mediate tumor suppressor activities. |
4. European Pancreatic Club Meeting, 2009. G. Lomberk, A Mathison, M Fernandez-Zapico, S Ilyas, C Demars, N Buttar, R Urrutia. KLF11 complexes with the epigenetic gene silencer protein, HP1 to mediate its tumor suppressor activities |
5. American Pancreatic Association Annual Meeting, 2009. A Liebl, A Mathison, J Bharrucha, V Shah, G Lomberk, R Urrutia. Generation of human, mouse, and rat pancreatic stellate cell lines for studying transcriptional control of extra cellular matrix synthesis |
6. American Pancreatic Association Annual Meeting, 2009. A Mathison, A Liebl, V Shah, G Lomberk and R Urrutia. Role of the KLF11-MMP pathway in stellate cell biology and tumor suppression. |
7. Digestive Disease Week Meeting, 2010. C Virk, A Mathison, C DeMars, U Shergill, G Lomberk S Sodavarapu, M Fernandez-Zapico, U Yaqoob, V Shah, R Urrutia, N Buttar. Distinct Stellate Cell Response to Injury in KLF11 Knockout Mice: Implications in Repair and Organ Dysfunction. |
8. American Pancreatic Association Annual Meeting, 2010. A Mathison, A Liebl, CJ DeMars, U Shergill, G Lomberk, V Shah, N Buttar and R Urrutia. Novel Tumor Suppresor Pathway in Pancreatic Cancer Derived from Selective Remodeling of Desmoplasia. |
9. American Pancreatic Association Annual Meeting, 2011. A Mathison, A Liebl, J Bharrucha, V Shah, G Lomberk, R Urrutia. Epigenetics in GI Organ Fibrosis: Generation of Mouse and Rat Pancreatic Stellate Cell Lines for Studying Epigenetic Control of Extracellular Matrix Synthesis |
10. American Pancreatic Association Annual Meeting, 2011. A Mathison, A Liebl, G Lomberk, CJ DeMars, U Shergill, V Shah, N Buttar, R Urrutia. Epigenetics in GI Organ Fibrosis: A KLF11-HDAC Mediated Pathway is Anti-fibrogenic in Liver and Pancreas. |
11. American Pancreatic Association Annual Meeting, 2013. G Lomberk, A Mathison, and R Urrutia. Epigenetic Signaling by HP1 Regulates KRAS-Induced Growth Promoting Gene Networks in Pancreatic Cancer Cells. |
12. American Pancreatic Association Annual Meeting, 2013. A Mathison, M Fernandez- Zapico, R Urrutia and G Lomberk. Preclinical Testing of a New Combinatorial Therapy Against Aurora A and G9a for the Treatment of Pancreatic Cancer. |
13. Midwest Chromatin and Epigenetics Meeting, 2014. Differential Regulation of HP1 Isoforms by Aurora Kinases during Mitosis. M Williams, A Mathison, G Lomberk and R Urrutia. |
14. American Pancreatic Association Annual Meeting, 2014. HP1-Histone Methyl Transferase Pathways Relay Epigenetic Signals Downstream of the Pancreatic Oncogenes, Aurora Kinases. M Williams, A Mathison, G Lomberk and R Urrutia. |
15. American Pancreatic Association Annual Meeting, 2014. Inactivation of the AurkA-HP1γ-G9a Pathway Synergistically Inhibits PDAC Cell Growth by Triggering Cell Death via Mitotic Catastrophe. A Mathison, M Williams, R Urrutia, G Lomberk. |
16. American Association for Cancer Research, 2017. Pharmacological targeting of the Aurora A and Histone 3 lysine 9 methyltransferase pathways in pancreatic cancer induces mitotic catastrophe. A. Mathison, A. Salmonson, M. Missfeldt, T. de Assuncao, J. Bintz, T. Christensen, S. Kossak, A. Nair, J. Iovanna, R. Huebert, G. Lomberk. |
17. American Association for Cancer Research, 2017. The epigenetic regulator, G9a, is a KRAS-inducible protein and its inactivation inhibits PanIN formation by this oncogene. A. Mathison, A. Salmonson, B. Paradise, M. Missfeldt, J. Iovanna, D. Billadeau, R. Urrutia, G. Lomberk. |
18. Academic Surgical Congress, 2019. The Early Epigenomic Landscape of Oncogenic KRAS Signaling. R. Kerketta, A. Mathison, A. Zeighami, J. Abrudan, W. Demos, M. Zimmermann, G. Lomberk, R. Urrutia. |
19. American Association for Cancer Research, 2019. Genomic variation in PDAC-predisposing genes identified using the MCW germline exome panel. J Abrudan, S Tsai, W Demos, M.T. Zimmermann, M Tschannen, J Geurts, A Mathison, G Lomberk, D Evans, R Urrutia. |
20. American Society of Human Genetics, 2020. Interpreting the wide genomic variation in PDAC predisposing genes. A. Mathison, M.T. Zimmermann, J.L. Abrudan, T. Stodola, W. Demos, M. Tschannen, M. Aldakkak, J. Geurts, S. Tsai, G. Lomberk, D. Evans, and R. Urrutia. |
21. Experimental Biology, 2022. Rho-related BTB Domain-containing Protein 1 Reverses Established Arterial Stiffness in Angiotensin II-treated Mice. S. Fang, J. Wu, J. Reho, K. Lu, D. Brozoski, A. Werthman, G. Kumar, S. Silva, P. Muskus, K. Wackman, A. Mathison, R. Urrutia, B. Teng, C. Lin, F. Quelle, C. Sigmund |
22. Experimental Biology, 2022. To ChIP, or to CUT, that is the question: Comparative Evaluation of NextGen Methodologies for Studying the genome-wide distribution of Histone H3 Lysine 9 di-methyl mark in pancreatic cells. G. Urrutia, J. Abrudan, M. Du, T. de Assuncao, A. Mathison, M. Zimmermann, G. Lomberk, R. Urrutia |
23. Experimental Biology, 2022. Defining the Mutational Landscape That Affects the Histone Demethylase KDM6A/UTX in Human Cancer. Y. Chi, T. Stodola, T. de Assuncao, B. Volkman, B. Smith, A. Mathison, G. Lomberk, M. Zimmermann, R. Urrutia
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24. Experimental Biology, 2022. Transcriptional Landscape Established by the Euchromatic Histone-lysine N-methyltransferase Pathway During Pancreas Ontogenesis and Pancreatitis. R. Urrutia, P. Vankayala, A. Salmonson, G. Urrutia, T. de Assuncao, M. Zimmermann, A. Mathison, G. Lomberk |
25. Experimental Biology, 2022. Epigenomic mechanisms used by KrasG12D to regulate inflammatory gene clusters in epithelial pancreatic cancer cells, which are critical for reprogramming the tumor microenvironment. M. Du, J. Abrudan, G. Urrutia, T. de Assuncao, A. Mathison, M. Zimmermann, G. Lomberk, R. Urrutia |
26. Experimental Biology, 2022. Integrative Modeling, Molecular Mechanics, and Molecular Dynamics Evaluation of Genomics Variants in KMT2C (MLL3), a Gene Involved in Kleefstra Syndrome Type 2. S. Jorge, Y. Chi, T. de Assuncao, A. Mathison, B. Volkman, B. Smith, G. Lomberk, M. Zimmermann, R. Urrutia |
27. American Association for Cancer Research, 2022. The splanchnic mesenchyme is the main tissue origin of fibroblasts in the pancreas during homeostasis and tumorigenesis. L. Han, Y. Wu, M. Parrish, K. Patel, T. Trimboli, J. Lefler, X. Yu, M. Zimmermann, A. Mathison, R. Urrutia, M. Ostrowski, G. Leone |
28. Society for Redox Biology and Medicine, 2022. Thioredoxin reductase 1 is required for maintenance of pancreatic beta-cell function and identity. J. Stancill, P. Hansen, A. Mathison, E. Schmidt, and J. Corbett |
29. American Society for Pharmacology and Experimental Therapeutics, 2023. Exploring the Synergy of G9a and ATM/ATR Pathway Interactions as a Precision Treatment Strategy in ATM-deficient Pancreatic Ductal Adenocarcinoma. M. Dzikowski, G. Pollin, T. de Assuncao, V. Gunia, E. Leverence, A. Mathison, G. Lomberk. |