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CURRICULUM VITAE

Anna H. Huppler MD
Assistant Professor
Department of Pediatrics
Division of Infectious Disease

OFFICE ADDRESS:
Children's Corporate Center
999 N 92 St
Milwaukee, WI 53226

EDUCATION:
08/1997 - 05/2001 B.S., Biochemistry and Molecular Biology (Highest Distinction), University of Wisconsin - Madison, Madison
08/1999 - 06/2000 Trans-Atlantic Science Student Exchange Program, Université Joseph Fourier, Grenoble, France
08/2002 - 06/2006 M.D., Dartmouth Medical School, Hanover, NH (Honors)

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
06/2006 - 06/2009 Internship & Residency, Pediatrics, University of Wisconsin Hospitals & Clinics, 600 Highland Avenue, Madison, WI
07/2010 - 06/2013 Fellow, Pediatric Infectious Diseases, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA
07/2013 - 06/2014 Research Fellow, Pediatric Infectious Diseases, University of Pittsburgh, Pittsburgh, PA

FACULTY APPOINTMENTS:
07/2009 - 06/2010 Diagnostic Referral Services, Department of Pediatrics, University of Pittsburgh Physicians, UPMC Mercy Hospital, 1400 Locust Street, Pittsburgh, PA 15219
07/2013 - 07/2014 Clinical Instructor, Department of Pediatrics, Division of Infectious Diseases, University of Pittsburgh Physicians/Children's Hospital of Pittsburgh of UPMC, 1 Children's Hospital Dr, 4401 Penn Avenue, Pittsburgh PA 15224
08/2014 - Present Assistant Professor, Department of Pediatrics, Division of Infectious Diseases, Medical College of Wisconsin/ Children's Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226
02/2017 - Present Assistant Professor, Department of Microbiology & Immunology, Graduate School of Biomedical Sciences, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226

ADMINISTRATIVE APPOINTMENTS:
None

EDUCATIONAL ADMINISTRATIVE APPOINTMENTS:
08/2014 - Present Director, Pediatric Infectious Diseases Residency Rotation
Department of Pediatrics, Division of Infectious Diseases, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226

HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS:
None

RESEARCH ADMINISTRATIVE APPOINTMENTS:
None

HOSPITAL STAFF PRIVILEGES:
07/2009 - 06/2010 UPMC Mercy Hospital, 1400 Locust Street, Pittsburgh, PA
07/2013 - 06/2014 Children's Hospital of Pittsburgh, One Children's Hospital Drive, 4401 Penn Avenue, Pittsburgh, PA
08/2014 - Present Children's Wisconsin, 9000 W. Wisconsin Avenue, Milwaukee, WI
08/2014 - Present Froedtert Memorial Lutheran Hospital, 9200 W. Wisconsin Avenue, Milwaukee, WI

AWARDS AND HONORS:
1997 - 2001 Dean's List, University of Wisconsin - Madison
05/2001 - Present College of Agricultural & Life Sciences Senior Award
06/2006 - Present Alpha Omega Alpha
06/2009 - Present Pediatric Resident Award
05/2012 - Present Pediatric Infectious Diseases Society Fellowship Award, Competitive, peer-reviewed selection process based on the applicant, mentor/environment, research plan, and potential for success as a clinical investigator in the field of pediatric infectious diseases
10/2013 - Present Milstein Travel Award Recipient, International Cytokine & Interferon Society
03/2016 - Present Department of Pediatrics Career Development Program Participant
05/2017 - 2016 'Expert Clinician' in the Department of Pediatrics, Awarded annually to the top 10% of Department providers in recognition of Program Expansion, Clinical Scholarship and/or "Clinician's Clinician" sta, then chosen by peer voting
05/2017 - 2016 'Expert Teacher' in the Department of Pediatrics, Awarded annually to the top 10% of Department faculty in recognition of overall teaching excellence, commitment to teaching learners, and dedication t, then chosen by peer and trainee voting
08/2017 - Present NIH Pediatric Loan Repayment Program Recipient
04/2018 - 2017 'Expert Teacher' in the Department of Pediatrics
04/2018 - 2017 'Expert Clinician' in the Department of Pediatrics
03/2019 - 2018 'Expert Teacher' in the Department of Pediatrics
03/2019 - 2018 'Expert Clinician' in the Department of Pediatrics
08/2019 - Present Best Doctors in America 2019-2020
01/2020 - 2019 'Expert Clinician' in the Department of Pediatrics
11/2020 - Present MCW Outstanding Medical Student Teacher for 2019-2020, Teaching Pin Recipient
05/2021 - 2020 'Expert Teacher' in the Department of Pediatrics
06/2021 - 2020 'Expert Clinician' and 'Master Clinician' in the Department of Pediatrics, Awardees who have been named Expert Clinician for five consecutive years earn the title of Master Clinician.

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Journal Review
05/2013 - Present Journal of the Pediatric Infectious Diseases Society
05/2013 - Present JAIDS
06/2013 - Present Pediatrics
11/2014 - Present Cytokine
06/2015 - Present Journal of Leukocyte Biology
07/2015 - Present PLoS One
05/2016 - Present Journal of Immunology
01/2017 - Present International Journal of Molecular Sciences
07/2017 - Present Experimental Lung Research
07/2018 - Present Scientific Reports
07/2018 - Present Hospital Practice
10/2019 - Present Pediatric Infectious Diseases Journal
05/2020 - Present Pediatric Transplantation
07/2020 - Present Clinical Infectious Diseases
11/2020 - Present Journal of Pediatric Hematology and Oncology
01/2021 - Present Journal of Clinical Rheumatology
04/2021 - Present Antibiotics
05/2021 - Present Journal of Patient-Centered Research and Reviews

LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
10/2014 - 02/2015 Clinical Advisory Team for Ebola Preparedness, Wisconsin Department of Public Health

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
11/2019 - Present Central Review Committee, International Pediatric Fungal Network DOMINIC Study
10/2020 - Present Ad Hoc Reviewer, Team Science Grants, The Wellcome Trust/DBT India Alliance

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Anti-Candida activity of CCL28 in Oropharyngeal Candidiasis
Source:
NIH, NIDCR, K08
Role:
Principal Investigator
PI:
Self
Dates:
05/2017 - 04/2022
Direct Funds:
$149,500
 
Title:
Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
Source:
NIH, NIAID, R01
Role:
Co-Investigator (site PI)
PI:
William Steinbach, Brian Fisher
Dates:
06/2018 - 05/2023
Direct Funds:
$8,000 (to date)
 
Title:
Anti-Candida activity of CCL28 in Oropharyngeal Candidiasis
Source:
NIH, NIDCR, K08-S1
Role:
Principal Investigator
PI:
Self
Dates:
08/2020 - 04/2022
Direct Funds:
$50,000
 
Non-Peer Review
Title:
Host Control of Candidiasis
Source:
Medical College of Wisconsin, Department of Pediatrics
Role:
Principal Investigator
PI:
Self
Dates:
08/2014 - 06/2022
 
Title:
Anti-Candida activity of CCL28 in Oropharyngeal Candidiasis
Source:
Children's Research Institute
Role:
Principal Investigator
PI:
Self
Dates:
05/2017 - 04/2022
Direct Funds:
$41,000
 
Prior
Peer Review
Title:
Advocacy and Independence Mentoring (AIM) - Organized and led a new support group for teens with chronic illness to address transitioning to adulthood
Source:
American Academy of Pediatrics Community Access to Child Health Program (CATCH) Grant
Role:
Principal Investigator
PI:
Self
Dates:
07/2007 - 06/2009
Direct Funds:
$2,850 (total from all years)
 
Title:
The IL-17 mediated regulation and role of neutrophils in resistance to oropharyngeal candidiasis
Source:
Research Advisory Committee of Children's Hospital of Pittsburgh of the UMPC Health System Fellowship Award
Role:
Principal Investigator
PI:
Self
Dates:
01/2012 - 12/2012
Direct Funds:
$39,869
 
Title:
The IL-17 mediated regulation and role of neutrophils in resistance to oropharyngeal candidiasis.
Source:
Pediatric Infectious Diseases Society Fellowship Award funded by the Stanley A. Plotkin Sanofi Pasteur Fellowship Award
Role:
Principal Investigator
PI:
Self
Dates:
07/2012 - 06/2014
Direct Funds:
$50,000
 
Title:
Multi-center studies to improve diagnosis and treatment of
Source:
NIH, NIAID, R01
Role:
Co-Investigator (site PI)
PI:
Theoklis Zaoutis, William Steinbach
Dates:
11/2013 - 11/2017
Direct Funds:
$1,000
 
Title:
Fungal Biomarkers for Diagnosis and Response to Therapy for
Source:
NIH, NICHD, R01
Role:
Co-Investigator (site PI)
PI:
William Steinbach, Brian Fisher
Dates:
03/2015 - 05/2020
Direct Funds:
$18,400
 
Title:
Live-Attenuated Vaccine for Protection from Candidiasis
Source:
Medical College of Wisconsin, Children's Research Institute
Role:
Principal Investigator
PI:
Self
Dates:
01/2016 - 12/2016
Direct Funds:
$75,000
 
Title:
Host susceptibility to pediatric nontuberculous mycobacterial
Source:
Medical College of Wisconsin, Research Affairs Committee, New
Role:
Principal Investigator
PI:
Self
Dates:
01/2017 - 06/2018
Direct Funds:
$25,000
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
"Triple Threat: Kingella kingae case presentation, " Infectious Diseases Grand Rounds, UPMC Presbyterian, Pittsburgh, PA, January 13, 2011
"Community-Acquired Pneumonia: Update on new guidelines, " Three Rivers Pediatric Update 2012, Pittsburgh, PA., May, 2012
"Lymphomatoid Granulomatosis: case presentation, " Infectious Diseases Grand Rounds, UPMC Presbyterian, Pittsburgh, PA, May 10, 2012
"Principles of Outbreak Investigation, " Fox Chapel Area Middle School Longitudinal Science Project, Pittsburgh, PA., January 28, 2013
"Vaccination in Pregnancy, " The Midwife Center for Birth & Women's Health. Pittsburgh, PA., February 4, 2013
"Multidrug resistant bacterial infection: case presentation, " Infectious Diseases Grand Rounds, UPMC Presbyterian, Pittsburgh, PA, April 4, 2013
"Red Book Update, " Three Rivers Pediatric Update 2013, Pittsburgh, PA., May 17, 2013
"Nontuberculous mycobacteria infection after stem-cell transplant: case presentation, " Infectious Diseases Grand Rounds, UPMC Presbyterian, Pittsburgh, PA, September 5, 2013
"Neutrophils in IL-17-dependent immunity to mucosal candidiasis, " Circle Seventeen Investigators, Pittsburgh, PA., October 9, 2013
"Vaccines: Tips and Tricks for promoting our greatest tools, " Three Rivers Pediatric Update 2014, Pittsburgh, PA, May 15, 2014
"IL-17 and neutrophils in defense from mucosal candidiasis, " Infectious Diseases Research Conference, Froedtert Hospital, April 16, 2015
"Challenges in the Management of ENT Infections, " Society of Otorhinolaryngology and Head Neck Nurses, Inc. 14th Annual Education Day, Milwaukee, WI, March 5, 2016
"Innate Immunity in Defense from Candida infections", Microbiology & Molecular Genetics Seminar Series, Medical College of Wisconsin, August 23, 2016
"Adult & Pediatric Vaccine Update, " Wisconsin Academy of Physician Assistants Fall Conference, Elkhart Lake, WI, October 13, 2016
"Can Host Defense from Candida Inspire Therapeutic Development?", Committee on Immunology's Annual Immunology Retreat, October 26, 2016
"Leveraging Immune Control of Candida to Combat Infection" Children's Research Institute Research Conference, December 16, 2016
"Infectious Disease", Ace the Boards, Medical College of Wisconsin/Department of Pediatrics Board Review Course, 2014, 2015, 2016, and 2017.
"Adventures in Airborne Isolation, " Southeastern Wisconsin APIC Chapter Monthly Meeting, Milwaukee, WI, November 2, 2017
"Immunology. The Best Offense is a Good Defense, " Conversations with Scientists Lecture Series, Presented by the Medical College of Wisconsin and Advancing a Healthier Wisconsin Endowment, Milwaukee, WI, October 16, 2018.
"K awards, " Medical College of Wisconsin Department of Pediatrics Grant Writing Retreat, Sheboygan, WI, March 8, 2019.
"The Importance of Childhood Vaccines: What They Are and Why Your Child Needs Them, " Science Café in collaboration with CTSI, Milwaukee, WI, August 27, 2019.
"The Importance of Childhood Vaccines: What They Are and Why Your Child Needs Them, " Science Café in collaboration with CTSI, Milwaukee, WI, August 26, 2020.
"Neutrophils and Oropharyngeal Candidiasis, " Fungal Pathogen Meeting: Carnegie Mellon University, Pittsburgh, PA., November, 2011
 
Regional
"Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis, " Fungal Supergroup Seminar Series, Madison, WI, November 21, 2013
"A Boy with Thrush: Review of CMC and STAT1 Mutations, " Joint Pediatric Immunodeficiency Conference (multicenter), Pittsburgh, PA, April 3, 2014
"Leveraging Immune Control of Candida to Combat Infection, " Lurie Children's Hospital of Chicago, Pediatric Infectious Diseases Special Seminar, Chicago, IL, January 23, 2019
 
National
"Infectious Disease in Transplantation, " North American Transplant Coordinators Organization (NATCO) Introductory Course for the New Transplant Professional & Procurement Professional, Tempe, AZ, June 12, 2016
"Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis, " St. Jude/Pediatric Infectious Diseases Society Research Conference, Memphis, TN, February 21, 2014
"Infectious Disease in the Donor, " North American Transplant Coordinators Organization (NATCO) Introductory Course for the New Transplant Professional & Procurement Professional, Tempe, AZ, June 12, 2016
"Minimizing & Managing Post-Transplant Infections, " North American Transplant Coordinators Organization (NATCO) Introductory Course for the New Transplant Professional & Procurement Professional, Tempe, AZ, June 10, 2017
"Infectious Disease Assessment in the Organ Donor, " North American Transplant Coordinators Organization (NATCO) Introductory Course for the New Transplant Professional & Procurement Professional, Tempe, AZ, June 11, 2017
"Prevention and Management of Post-Transplant Infections, " North American Transplant Coordinators Organization (NATCO) Introductory Course for the New Transplant Professional & Procurement Professional, Tempe, AZ, November 3, 2018
"Infectious Disease Evaluation in the Organ Donor, " North American Transplant Coordinators Organization (NATCO) Introductory Course for the New Transplant Professional & Procurement Professional, Tempe, AZ, November 4, 2018
"Mycobiome and Invasive Fungal Infections, " Session Moderator, IDWeek 2019, Washington, DC, October 4, 2019
"Pre- and Post-Transplant Prevention and Treatment of Infections, " North American Transplant Coordinators Organization (NATCO) Introductory Course for the New Transplant Professional & Procurement Professional, Tempe, AZ, November 6, 2019
"Organ Donor and Infectious Disease Assessment, " North American Transplant Coordinators Organization (NATCO) Introductory Course for the New Transplant Professional & Procurement Professional, Tempe, AZ, November 7, 2019
 

PEER REVIEWED WORKSHOPS/PRESENTATIONS:
Local
HUPPLER, A.R., Hernández-Santos, N., Conti, H.R., Gaffen. S.L. Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis. Committee on Immunology Conference, Blood Center of Wisconsin, Milwaukee, WI, 2014.
HUPPLER, A.R., Hernández-Santos, N., Darville, T., Gaffen, S.L. The IL-17-mediated regulation and role of neutrophils in resistance to oropharyngeal candidiasis. University of Pittsburgh Department of Medicine Research Day, Pittsburgh, PA, 2012.
HUPPLER, A.R., Hernández-Santos, N., Conti, H.R., Gaffen. S.L. CXCR2 and myeloid cells are essential to host defense from oropharyngeal candidiasis. University of Pittsburgh Department of Medicine Research Day, Pittsburgh, PA, 2013.
HUPPLER, A.R., Conti, H.R., Hernández-Santos, N., Gaffen, S.L. CXCR2 and myeloid cells participate in host defense from oropharyngeal candidiasis. 3rd Annual Rangos Research Symposium, Pittsburgh, PA, 2013. Award finalist
 
National
HUPPLER, A.R., Eickhoff, J.D., Wald, E.R. Performance of Low-Risk Criteria in the Evaluation of Young Infants with Fever: Review of the Literature. Infectious Diseases Society of America Annual Meeting, Philadelphia, PA, 2009.
HUPPLER, A.R., Hernández-Santos, N., Darville, T., Gaffen, S.L. The IL-17-mediated regulation and role of neutrophils in resistance to oropharyngeal candidiasis. St Jude/PIDS Pediatric Infectious Diseases Research Conference, Memphis, TN, 2012.
HUPPLER, A.R., Hernández-Santos, N., Darville, T., Gaffen, S.L. The IL-17/IL-23-mediated role of neutrophils in resistance to oropharyngeal candidiasis. Infectious Diseases Society of America Annual Meeting, San Diego, CA, 2012. • Oral Abstract Presentation
HUPPLER, A.R., Hernández-Santos, N., Conti, H.R., Gaffen, S.L. The role of neutrophils in resistance to oropharyngeal candidiasis. Gordon Research Conference on Immunology of Fungal Infections, Galveston, TX, 2013.
HUPPLER, A.R., Conti, H.R. Hernández-Santos, N., Gaffen, S.L. Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis. Meeting of the International Cytokine & Interferon Society, San Francisco, 2013. • Oral Abstract Presentation, Milstein Travel Award Recipient
HUPPLER, A.R., Hernández-Santos, N., Conti, H.R., Gaffen, S.L. Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis. Gordon Research Conference on Immunology of Fungal Infections, Galveston, TX, 2015.
He, J., Thomas, M.A., Grayson, M.H., Volkman, B.F., HUPPLER, A.R. CCL28 antimicrobial properties and defense from oropharyngeal candidiasis. 14th American Society for Microbiology Conference on Candida and Candidiasis, Providence, RI, 2018. • Oral Abstract Presentation
Zembles, T.N., Kissell, A., Havens, P.L., Huppler, A.R. Assessment of a pharmacist-driven voriconazole clinical practice guideline in a children's hospital. IDWeek 2018, San Francisco, CA, 2018.
He, J., Thomas, M.A., Grayson, M.H., Volkman, B.F., HUPPLER, A.R. CCL28 antimicrobial properties and defense from oropharyngeal candidiasis. Gordon Research Conference on Immunology of Fungal Infections, Galveston, TX, 2019. • Invited Speaker
HUPPLER, A.R., He, J., Volkman, B.F., Grayson, M.H. An intact C-terminus is required for the antimicrobial effects of CCL28 in host defense from oropharyngeal candidiasis. Immunology, Seattle, 2016. • Oral Abstract Presentation
 

COMMITTEE SERVICE:
Medical College of Wisconsin
08/2014 - Present Infection Control Committee, Children's Wisconsin, Ad hoc chair during absence of the permanent chair, including coverage during major infection prevention events, such as nosocomial varicella exposures
08/2014 - Present Antimicrobial Stewardship Program, Children's Wisconsin, Ad hoc advisor to pharmacists, collaborator for multiple clinical improvement projects
06/2015 - 10/2015 Pediatric Fellowship Funding Committee, Medical College of Wisconsin
02/2016 - 01/2017 Pediatric Infectious Diseases Division Chief Search Committee
02/2019 - Present Critically Immunocompromised Patient Committee
09/2020 - Present Institutional Biosafety Committee
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Community/Lay Public
10/2018 - Present Invited speaker, Conversations with Scientists Lecture Series, Medical College of Wisconsin and Advancing a Healthier Wisconsin Endowment
08/2019 - Present Invited discussion leader, Science Café in collaboration with CTSI
08/2020 - Present Invited discussion leader, Science Café in collaboration with CTSI
10/2020 - Present Interview Guest, Program on Vaccinations, CTSI Discovery Radio
 
Medical Student Education
03/2016 - Present Lecturer, Mycology, Infectious Agents and Host Immunity Course
08/2017 - Present Preceptor, Case-Based Discussions, Molecules to Cells Course
 
Resident and Fellow Education
08/2014 - Present SurfBoards series presenter, Pediatric Resident Board Review
08/2014 - Present Adult Infectious Diseases Fellow Teaching, Pediatric Infectious Diseases Rotation
09/2014 - 05/2015 Series Presenter, Joint Pediatric-Adult Infectious Diseases Case Conference
12/2014 - Present Presenter, Fungal Infections, Pediatric Resident Noon Conference
12/2014 - Present Presenter, Parasitic Infections, Pediatric Resident Noon Conference
01/2015 - 02/2019 Faculty facilitator, Intern Morning Report
12/2016 - Present Invited speaker, Cytomegalovirus and Liver Disease, GI Fellowship Liver Education Series
03/2018 - Present Invited speaker. Unusual Liver Infections, GI Fellowship Liver Education Series
04/2018 - Present Invited speaker, Fungal Infections, Critical Care Fellowship Education Series
11/2018 - Present Invited speaker, Infectious Diseases Topics, Emergency Medicine Fellowship Education Series
12/2018 - Present Invited speaker, Cytomegalovirus, GI Fellowship Liver Education Series
03/2019 - Present Faculty facilitator, Senior Resident Rounds
06/2020 - Present Invited speaker, Fungal Infections: Diagnostic and Therapeutic Considerations, Critical Care Education Series
09/2020 - Present Invited speaker, Infections of the Liver, GI Fellowship Liver Education Series
11/2020 - Present Invited speaker, CNS infections, Emergency Medicine Fellowship Education Series
04/2021 - Present Invited speaker, Fever of Unknown Origin, Hospital Medicine Fellowship Education Series
 
Continuing Medical Education
08/2014 - 08/2017 Presenter, Infections Diseases, Ace the Boards, Pediatric Board Review Course
08/2015 - Present Invited speaker, Fever of Unknown Origin, Hospital Medicine Division Professional Development Series
09/2019 - Present Invited speaker, Fever of Unknown Origin: joint ID/Rheumatology presentation, Hospital Medicine Division Professional Development Series
 
Graduate Student Education
10/2014 - 09/2018 Poster Judge for Graduate School of Biomedical Sciences and Office of Postdoctoral Education Annual Research Poster Day
03/2016 - 08/2020 Instructor, Mucosal Immunology Course
10/2018 - 11/2019 Lecturer, Immune Responses to Fungi & Integrated Paper Discussion, Cellular and Molecular Immunology Course
 

EXTRAMURAL TEACHING:
Continuing Medical Education
03/2016 - Present Invited speaker, ENT Infections, ENT Nurses Annual Education Day
06/2016 - Present Invited speaker, Infectious Diseases in Transplantation and Infectious Disease in the Donor, North American Transplant Coordinators Organization Annual Introductory Course
10/2016 - Present Invited speaker, Vaccines, Wisconsin Academy of Physician Assistants Fall CME Conference
 

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Medical Students
Erin Myers, MCW, 11/01/2014 - 06/01/2017 Pathway Mentor, Making Health Literacy Child’s Play, featured pathway poster
Alyssa Colby, MCW, 04/01/2016 - 07/01/2016 Clinical Shadowing Experience
Lauren Barta, MCW, 05/01/2016 - Present Clinical Shadowing Experience
Kevin Schlidt, MCW, 11/2016 - 06/2020 Pathway Mentor, IDweek poster
Zoe Morgan, MCW, 12/2016 - Present Clinical Shadowing Experience
Nisreen Mobayed, MCW, 08/2017 - 10/2020 Research Project Mentor, IDweek poster
Samantha Lauhon, MCW, 11/2017 - Present Pathway & Research Project Mentor, ATC and PAS posters
Sarah Park, MCW, 11/2017 - 04/2021 Research Project Mentor, PAS poster
Jenna Cormier, MCW, 03/2021 Clinical Shadowing Experience
Rachel Weber, MCW, 06/2021 - Present Clinical Shadowing Experience
 
Clinical/Research Fellows
Lauren Pommert, MCW, 11/2016 - 06/2019 Scholarship Oversight Committee Member
Ranjeet Minocha, MCW, 07/2017 - 06/2018 Scholarship Oversight Committee Member
Brian Carroll, MCW, 06/2018 - 06/2020 Scholarship Oversight Committee Member
Brittany Player, MCW, 11/2020 - Present Project Mentor and Scholarship Oversight
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
Residents
Jaimee Hall, CHW, 10/2017 - 06/2020 Residency Advisor and Research Mentor, Publication, ID fellow
Nina Morgan, CHW, 07/2018 - 06/2020 Residency Advisor
Brittany Lehrer, CHW, 07/2020 - Present Research Mentor, ID fellowship
Joana Dimo, CHW, 08/2020 - Present Research Mentor, Abstract at national meeting, MCW QI award
Charlotte Formeller, CHW, 08/2020 - Present Residency Advisor
Natalia Beneschott, CHW, 10/2020 - Present Quality Improvement Project Mentor
Andy Vega, CHW, 07/2021 - Present Residency Advisor
 

PROGRAMMATIC DEVELOPMENTS:
Educational Programs
Resident
09/2015 - 06/2017 Pager Communication QI project, Project Team Member
10/2020 - Present Asplenia Vaccine QI project, Faculty mentor
Faculty
02/2015 - 12/2018 Clinical Practice Guidelines Author- Febrile Neonate
09/2015 - 01/2019 Clinical Practice Guidelines Advisor- Community Acquired
04/2016 - Present Clinical Practice Guidelines Author- Osteomyelitis and Septic Arthritis
Pneumonia with Pleural Effusion
 
Research Programs
11/2015 - 11/2017 Persistent CSF HSV Study site PI
02/2016 - Present International Pediatric Fungal Network site PI
02/2017 - 02/2018 Anidulafungin Pediatric Study site co-PI
10/2019 - Present Live-Viral Vaccination after Pediatric Transplantation site co-I
Multicenter observational study to understand safety, efficacy, and
Collaborative group of investigators and centers focused on pediatric invasive fungal infections.
immunogenicity of live viral vaccination after liver or kidney transplant.
 
Clinical Programs
09/2014 - 03/2018 Antimicrobial Lock Therapy Protocol Development
10/2014 - Present Cardiac Transplant Infectious Diseases Advisor
01/2016 - Present Voriconazole CPG Process Evaluation
05/2018 - 06/2021 Improving vaccination rates after liver transplant- Quality Improvement Project
08/2019 - Present Improving endocarditis specimen handling and order entry- Quality Improvement Project
01/2021 - Present Childhood Vaccination Disparity Project
Expanded treatment options for central-line associated infections at CHW, including education of providers and staff, creation of pharmacy and EMR protocols, and committee approvals.
Develop evidence-based protocols, supply monthly program support, provide transplant ID advice, initiated routine ID involvement in pre-transplant evaluations.
Community Programs None
 
 

COMMUNITY SERVICE ACTIVITIES:
09/2014 - 05/2016 Saint Jude Church Choir Member
06/2021 - Present Volunteer, Saint John Vianney School
 

GLOBAL HEALTH ACTIVITIES:
None
 

SPECIALTY BOARDS AND CERTIFICAITONS::
10/01/2009 - 12/01/2023 American Board of Pediatrics- General Pediatrics
11/01/2013 - 12/01/2023 American Board of Pediatrics- Infectious Diseases


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. HUPPLER, A.*, Nikstad L.J.*, Allmann A.M., Brow D.A., Butcher S.E..: Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure. Nat Struct Biol 9:431-5, 2002. PMID 11992125. *Authors contributed equally
2. Wang, Y., Kedei, N., Wang, M., Wang, Q.J., HUPPLER, A.R., Toth, A., Tran, R., Blumberg, P.M.: Interaction between protein kinase Cmu and the vanilloid receptor type 1. J Biol Chem 279:53674-82, 2004. PMID 15471852.
3. Lu, G., Chen, J., Espinoza, L.A., Garfield, S., Toshiyuki, S., Akiko, H., HUPPLER A., Wang Q.J.: Protein kinase D 3 is localized in vesicular structures and interacts with vesicle-associated membrane protein 2. Cell Signal19:867-79, 2007. PMID 17196367.
4. HUPPLER, A.R., Eickhoff, J.C., Wald, E.R..: Performance of Low-Risk Criteria in the Evaluation of Young Infants With Fever: Review of the Literature. Pediatrics 125:228-233, 2010. PMID 20083517.
5. Hernández-Santos, N., HUPPLER, A.R., Peterson, A.C., Khader, S.A., McKenna, K.C., Gaffen, S.L.: Th17 cells confer long term adaptive immunity to oral mucosal Candida albicans infections. Mucosal Immunol 6(5):900-10, Sept., 2013. PMID 23250275.
6. Bishu, S., Hernández-Santos, N., Simpson-Abelson, M.R., HUPPLER, A.R., Conti, H.R., Ghilardi, N., Mamo, A., Gaffen, S.L.: The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections. Infect Immun 82(3):1173-80, March 2014. PMID 24379290.
7. HUPPLER, A.R., Conti, H.R., Hernández-Santos, N., Darville , T., Biswas, P., Gaffen, S.L.: Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis. J Immunol 192(4):1745-52, Feb. 15, 2014 PMID 24442441.
8. Conti, H.R., HUPPLER, A.R., Whibley, N, Gaffen, S.E.: Animal models for candidiasis. Curr Protoc Immunol. 105:19.6.1-19.6.17, Apr 2, 2014. PMID 24700323.
9. Ramani, K., Pawaria, S., Maers, K., HUPPLER, A.R., Gaffen, S.L., Biswas, P.S.: An essential role of interleukin-17 receptor signaling in the development of autoimmune glomerulonephritis. J Leukoc Biol. 96(2);463-72. Sept, 2014. PMID 24935958.
10. Conti, H.R., Peterson, A.C., Brane, L., HUPPLER, A.R., Hernández-Santos, N., Whibley, N., Garg, A.V., Simpson-Abelson, M.R., Gibson, G.A., Mamo, A.J., Osborne, L.C., Bishu, S., Ghilardi, N., Siebenlist, U., Watkins, S.C., Artis, D., McGeachy, M.J., Gaffen, S.L.: Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections. J Exp Med.211(10):2075-84. Sept 22, 2014. PMID 252000028.
11. HUPPLER, A.R., Verma, A.H., Conti, H.R., Gaffen, S.L.: Neutrophils Do Not Express IL-17A in the Context of Acute Oropharyngeal Candidiasis. Pathogens. 4(3):559-72. Jul 24, 2015. PMID 26213975.
12. HUPPLER, A.R., Whibley, N., Woolford, C.A., Childs, E.E., He, J., Biswas, P.S., McGeachy, M.J., Mitchell, A.P., Gaffen, S.L.: A Candida albicans strain expressing mammalian IL-17A results in early control of fungal growth during disseminated infection. Infect Immun. 2015 Sep;83(9):3684-92. PMID 26150537.
13. Zembles, T.N., Thompson, N.E., Havens, P.L., Kaufman, B.A., HUPPLER, A.R.: An Optimized Voriconazole Dosing Strategy to Achieve Therapeutic Serum Concentrations in Children Younger Than 2 Years Old. Pharmacotherapy. 2016 Oct;36(10):1102-1108. PMID 27548272.
14. Verma, A.H., Richardson, J.P., Zhou, C., Coleman, B.M., Moyes, D.L., Ho, J., HUPPLER, A.R., Ramani, K., McGeachy, M.J., Mufazalov, I., Kane, L.P., Biswas, P.S., Hube, B., Naglik, J.R., Gaffen, S.L.: Oral epithelial cells orchestrate innate type 17 responses to Candida albicans via the virulence factor candidalysin. Science Immunol. 2017 Nov 3;2(17). PMID 29101209.
15. Zembles, T.N., Flannery, L.S., Huppler, A.R.: Development and implementation of an antimicrobial lock guideline in a pediatric hospital. Am J Health Syst Pharm. 2018 Mar 1;75(5):299-303. PMID 29472511.
16. Thomas, M.A., He, J., Peterson, F.C., Huppler, A.R., Volkman, B.F.: The Solution Structure of CCL28 Reveals Structural Lability that Does Not Constrain Antifungal Activity. J Mol Biol. 2018 Sep 14;;430(18 Pt B):3266-3282. PMID 29913161.
17. Erker, C., HUPPLER, A.R., Walsh, T.J., McCormick, M.E., Suchi, M., Bhatt, N.S., Kehl, S.C., Southwood, J., Harker-Murray, P.: Successful Treatment of Invasive Conidiobolus Infection During therapy for Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2018 Oct;40(7):e446-e449. PMID 28991126.
18. Claeys, T.A., Rosas Mejia, O., Marshall, S., Jarzembowski, J.A., Hayes, D., Hull, N.M., Liyanage, N.P.M., Chun, R.H., Sulman, C.G., Huppler, A.R., Robinson, R.T.: Attenuation of Helper T Cell Capacity for TH1 and TH17 Differentiation in Children with Nontuberculous Mycobacteria Infection. J Infect Dis. 2019 Oct 22;220(11):1843-1847. PMID 31332447.
19. Peters, B.M., Coleman, B.M., Willems, H.M.E., Barker, K.S., Aggor, F.E.Y., Cipolla, E., Verma, A.H., Bishu, S., Huppler, A.H., Bruno, V.M., Gaffen, S.L.: The IL-17R/IL-22R signaling axis is dispensable for vulvovaginal candidiasis regardless of estrogen status. J Infect Dis. 2019 Dec 5. PMID 31805183.
20. Dishman, A.F., Lee, M.W., de Anda, J., Lee, E.Y., He, J., Huppler, A.R., Wong, G.C.L., Volkman, B.F.: Switchable Membrane Remodeling and Antifungal Defense by Metamorphic Chemokine XCL1. ACS Infect Dis. 2020 Apr 15. PMID 32243126.
21. He, J., Thomas, M.A., de Anda, J., Lee, M.W., Van Why, E., Simpson, P., Wong, G.C.L., Grayson, M.H., Volkman, B.F., Huppler, A.R.: Chemokine CCL28 is a potent therapeutic agent for oropharyngeal candidiasis. Antimicrob Agents Chemother. 2020 Jul 22;64(8):e00210-20. PMID 32423961.
22. Jondle, C.N., Johnson, K.E., Aurubin, C., Sylvester, P., Xin, G., Cui, W., Huppler, A.R., Tarakanova, V.L. Gammaherpesvirus Usurps Host IL-17 Signaling To Support the Establishment of Chronic Infection. mBio. 2021 Apr 6;12(2):e00566-21. PMID 33824206.
23. Hall, J.M., Havens, P.L., Mitchell, E.A., De Vela, G.N., Titus, L.L., Dasgupta, M., Simpson, P.M., Kehl, S.C., Willoughby, R.E., Henrickson, K.J., Mitchell, M.L., Huppler, A.R., Chusid, M.J.. Blastomycosis in 64 Wisconsin Children: Unanticipated Infection Risk and Severity in Urban Residents. Pediatr Infect Dis J. 2021 May 7. PMID 33990518.
24. Dishman, A.F., He, J., Volkman, B.F., Huppler, A.R. Metamorphic protein folding encodes multiple anti-Candida mechanisms in XCL1. Pathogens. 2021 Jun 17;10(6)762. PMID 34204234.
25. Gumm, A.J., Lerret, S., Zeman, M., Rueter, J., Huppler, A.R., Khan, Z., Telega, G., Vitola, B. Quality Improvement Project to Improve Vaccinations in the Pediatric Liver Transplant Population. Pediatric Transplantation. 2021 Jun 29:e14076. PMID 34185930.
26. Fisher B.T., Zaoutis T.E., Xiao R., Wattier R.L., Castagnola E., Pana Z.D., Fullenkamp A., Boge C.L.K., Ross R.K., Yildirim I., Palazzi D.L., Danziger-Isakov L., Vora S.B., Arrieta A., Yin D.E., Avilés-Robles M., Sharma T., Tribble A.C., Maron G., Berman D., Green M., Sung L., Romero J., Hauger S.B., Roilides E., Belani K., Nolt D., Soler-Palacin P., López-Medina E., Muller W.J., Halasa N., Dulek D., Hussain I.Z.B., Pong A., Hoffman J., Rajan S., Gonzalez B.E., Hanisch B., Aftandilian C., Carlesse F., Abzug M.J., Huppler A.R., Salvatore C.M., Ardura M.I., Chakrabarti A., Santolaya M.E., Localio A.R., Steinbach W.J. Comparative Effectiveness of Echinocandins vs Triazoles or Amphotericin B Formulations as Initial Directed Therapy for Invasive Candidiasis in Children and Adolescents. J Pediatric Infect Dis Soc. 2021 Aug 10. PMID 34374424.
 
Books, Chapters, and Reviews
1. HUPPLER, A.R., Bishu, S., Gaffen, S.L.: Mucocutaneous Candidiasis: implications for targeted immunotherapy. Arthritis Res Ther 14(4):217, 2012. PMID 22838497.
2. Robinson, R.T., HUPPLER, A.R.: The Goldilocks model of immune symbiosis with Mycobacteria and Candida colonizers. Cytokine 2017 Sep;97:49-65. PMID 28570933.
3. HUPPLER, A.R., Fisher, B.T., Lehrnbecher, T., Walsh, T.J., Steinbach, W.J.: Role of Molecular Biomarkers in the Diagnosis of Invasive Fungal Diseases in Children. J Pediatr Infect Dis Soc. 2017 Sep 1;6(suppl_1):S32-S44. PMID 28927202.
4. Mohandas, S., Gregory, S., Chun, R.H., HUPPLER, A.R.: Pediatric deep neck space infections: a medical and surgical perspective. J Pediatr Infect Dis. 2019 Feb;14(2):043-051.
5. HUPPLER, A.R. Infectious Complications of HSCT. Nelson Textbook of Pediatrics, 21st ed. Robert Kliegman, Joseph St. Geme, Ed. Elsevier. 2019.
6. HUPPLER, A.R. Fever. Nelson Pediatric Symptom-Based Diagnosis: Common Disorders and Their Mimics, 2nd ed. Robert Kliegman, Brett Bordini, Donald Basel, Heather Toth. Elsevier. 2022. In revision.
 
Editorials, Letters to Editor, Other
1. HUPPLER, A.R., Gaffen, S.L.: Editorial: Fake it 'til you make it: mast cells acquire IL-17 exogenously. J Leukoc Biol. 2016 Sep;100 (3): 445-46. PMID 27587375.
 
Abstracts
1. Wang, Y., Kedei, N., Wang, M., Wang, Q.J., HUPPLER, A.R., Toth, A., Tran, R., Blumberg, P.M.: The interaction between PKCmu and the vanilloid receptor VR1. Society for Neuroscience, Orlando, FL, 2002.
2. Hernández-Santos, N., Peterson, A.C., HUPPLER, A.R., Khader, S.A., McKenna, K.C., Gaffen, S.L. Cellular mediators of long-term protective immunity to Candida albicans in oropharyngeal candidiasis. American Society of Microbiology Candida and Candidiasis Conference, San Francisco, CA, 2012.
3. Conti, H.R., Peterson, A.C., Herrnández-Santos, N., HUPPLER, A.R., Bishu, S., Gaffen, S.L. Innate CD3+ CD4- CD8- Lymphocytes important in acute oropharyngeal candidiasis. Gordon Research Conference on Immunology of Fungal Infections, Galveston, TX, 2013.
4. Hernández-Santos, N., HUPPLER, A.R., Peterson, A.C., Khader, S.A., McKenna, K.C., Gaffen, S.L. Th17 cells confer long-term adaptive immunity to Oropharyngeal Candidiasis. Gordon Research Conference on Immunology of Fungal Infections, Galveston, TX, 2013.
5. Hernández-Santos, N., HUPPLER, A.R., Peterson, A.C., Khader, S.A., McKenna, K.C., Gaffen, S.L. Th17 cells confer long-term adaptive immunity to Oropharyngeal Candidiasis. Immunology 2013, Honolulu, HI, 2013.
6. Bishu, S., Hernández-Santos, N., Simpson-Abelson, M.R., HUPPLER, A.R., Conti, H.R., Ghilardi, N., Mamo, A., Gaffen, S.L.: The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections. Immunology 2014, Pittsburgh, PA.
7. Conti, H., Peterson, A., Hernández-Santos, N., Brane, L., HUPPLER, A., Whibley, N., Hamilton, K., Garg, A., Bishu, S., Simpson-Abelson, M., Mamo, A.J., Artis, D., Thomson, A., Watkins, S., McGeachy, M., Gaffen, S. "Natural" Th17 cells control Candida albicans infections in the oral mucosa. Immunology 2014, Pittsburgh, PA.
8. Biswas, P., Ramani, K., Maers, K., HUPPLER, A., Gaffen, S.L. Neutralization of IL-17 Ameliorated Kidney Pathology Associated with Immune-Complex Mediated Autoimmune Glomerulonephritis. American College of Rheumatology Annual Meeting, Boston, MA, 2014.
9. Erker, C., Huppler, A., Walsh, T., Bhatt, N., Harker-Murray, P. Invasive Conidiobolus Infection: Management during Induction Therapy for Acute Lymphoblastic Leukemia. American Society of Pediatric Hematology/Oncology, Minneapolis, MN, 2016.
10. Jondle, C.N., Johnson, K.E., Aurubin, C., Sylvester, P., Xin, G., Huppler, A.R., Tarakanova, V.L. A novel proviral function for IL-17 during gammaherpesvirus infection. Immunology 2019, San Diego, CA, 2019.
11. Gumm, A.J., Lerret, S., Zeman, M., Hogan, J., Huppler, A.R., Telega, G., Vitola, B. Live Vaccines for Pediatric Liver Transplant Recipients: A Quality Improvement Project. 24th Annual Society of Pediatric Liver Transplantation 2019 annual Conference, Houston, TX, 2019.
12. Hahn, D., Mobayed, N., Schlidt, K., Simpson, P., Huppler, A.R. Osteoarticular Infections in Children: A Case for a Disease-Specific Antibiogram and Implications for Treatment., Pediatric Hospital Medicine Meeting, Orlando, FL, 2020. (meeting cancelled due to COVID-19 pandemic).
13. Coleman, B.M., Peters, B.M., Willems, H.M.E., Barker, K.S., Aggor, F.E.Y., Cipolla, E., Verma, A.H., Bishu, S., Huppler, A.H., Bruno, V.M., Gaffen, S.L. IL17 and Candida albicans colonization in the vaginal mucosa. Immunology 2020 (meeting cancelled due to COVID-19 pandemic).
14. He, J., Volkman, B.F., Grayson, M.H., HUPPLER, A.R. Anti-Candida activity of CCL28 in oropharyngeal candidiasis. Committee on Immunology Conference, Blood Center of Wisconsin, Milwaukee, WI, 2015. Poster Presentation.
15. He, J., Thomas, M.A., Grayson, M.H., Volkman, B.F., HUPPLER, A.R. CCL28 acts as an antimicrobial peptide in host defense from OPC through an IL-23/Il-17 dependent pathway, Committee on Immunology- Annual Immunology Retreat, Blood Center of Wisconsin, Milwaukee, WI, 2016. Poster Presentation.
16. He, J., Thomas, M.A., Grayson, M.H., Volkman, B.F., HUPPLER, A.R. Optimization of antifungal efficacy of CCL28 peptide in mouse oropharyngeal candidiasis model. Committee on Immunology- Annual Immunology Retreat, Blood Center of Wisconsin, Milwaukee, WI, 2017. Poster Presentation.
17. He, J., Thomas, M.A., Grayson, M.H., Volkman, B.F., HUPPLER, A.R. CCL28 antimicrobial properties and defense from oropharyngeal candidiasis. Committee on Immunology- Annual Immunology Retreat, Blood Center of Wisconsin, Milwaukee, WI, 2018. Poster Presentation.
18. Mobayed N., Schlidt K., Roadman, D., Hahn, D., Huppler, A.R. Septic Arthritis and Acute Hematogenous Osteomyelitis in Children: Disease-Specific Antibiogram and Implications for Treatment. IDWeek 2019, Washington D.C., 2019. Poster Presentation.
19. He, J., Thomas, M.A., Van Why E., Grayson, M.H., Volkman, B.F., HUPPLER, A.R. Chemokine CCL28 treats oropharyngeal candidiasis through rapid membrane disruption. Immunology 2020, Honolulu, HI, 2020
20. Lauhon, S.R., Stendahl, G., Kindel, S.J., Punnoose, A.R., Huppler, A.R. Impact of Infectious Disease Intervention on Vaccine Compliance in Pediatric Heart Transplant Patients. American Transplant Congress 2020, Philadelphia, PA, 2020 Poster Presentation. (virtual meeting due to COVId-19 pandemic)
21. Lauhon, S.R., Stendahl, G., Kindel, S.J., Punnoose, A.R., Huppler, A.R. Impact of Infectious Disease Intervention on Vaccine Compliance in Pediatric Heart Transplant Patients. Pediatric Academic Societies Meeting, Philadelphia, PA, 2020 (meeting canceled due to COVID-19 pandemic).
22. Park, S., Pollow, A., Kindel, S.J., Huppler, A.R., Punnoose, A.R. Antiviral prophylaxis protocol implementation in pediatric cardiac transplant. Pediatric Academic Societies Meeting, Philadelphia, PA, 2020 (meeting canceled due to COVID-19 pandemic).
23. Hall J.M., Havens P.L., Mitchell E.A., De Vela G.N., Titus L.L., Dasgupta M., Simpson P.M., Kehl S.C., Willoughby R.E., Henrickson K.J., Mitchell M.L., Huppler A.R., Chusid M.J. Blastomycosis in 64 Wisconsin Children: Unanticipated Infection Risk and Severity in Urban Residents. PIDS St. Jude Conference, 2021. Virtual Poster Presentation.
24. Dimo, J., Hahn, D., Huppler, A.R. Use of Clinical Practice Guideline to Improve Management of Septic Arthritis and Acute Hematogenous Osteomyelitis in Children. Pediatric Hospital Medicine Conference, 2021. Virtual Poster Presentation.
 
Patents
1. United States Patent: 10.160.974, granted on December 25, 2018. Gaffen, S.L., McGeachy, M.J., HUPPLER, A.R., Mitchell, A.P. University of Pittsburgh and Carnegie Mellon University. Engineered cytokine- and chemokine-expressing Candida albicans strains and methods of use.