CURRICULUM VITAE
Anna H. Huppler MD
Anna H. Huppler MD
Associate Professor
Department of Pediatrics
Division of Infectious Disease
Department of Pediatrics
Division of Infectious Disease
OFFICE ADDRESS: |
Children's Corporate Center |
999 N 92 St |
Milwaukee, WI 53226 |
EDUCATION: |
08/1997 - 05/2001 B.S., Biochemistry and Molecular Biology (Highest Distinction), University of Wisconsin - Madison, Madison |
08/1999 - 06/2000 Trans-Atlantic Science Student Exchange Program, Université Joseph Fourier, Grenoble, France |
08/2002 - 06/2006 M.D., Dartmouth Medical School, Hanover, NH (Honors) |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
06/2006 - 06/2009 Internship & Residency, Pediatrics, University of Wisconsin Hospitals & Clinics, 600 Highland Avenue, Madison, WI |
07/2010 - 06/2013 Fellow, Pediatric Infectious Diseases, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA |
07/2013 - 06/2014 Research Fellow, Pediatric Infectious Diseases, University of Pittsburgh, Pittsburgh, PA |
FACULTY APPOINTMENTS: |
07/2009 - 06/2010 Diagnostic Referral Services, Department of Pediatrics, University of Pittsburgh Physicians, UPMC Mercy Hospital, 1400 Locust Street, Pittsburgh, PA 15219 |
07/2013 - 07/2014 Clinical Instructor, Department of Pediatrics, Division of Infectious Diseases, University of Pittsburgh Physicians/Children's Hospital of Pittsburgh of UPMC, 1 Children's Hospital Dr, 4401 Penn Avenue, Pittsburgh PA 15224 |
08/2014 - Present Assistant Professor, Department of Pediatrics, Division of Infectious Diseases, Medical College of Wisconsin/ Children's Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226 |
02/2017 - Present Assistant Professor, Department of Microbiology & Immunology, Graduate School of Biomedical Sciences, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 |
ADMINISTRATIVE APPOINTMENTS: |
None |
EDUCATIONAL ADMINISTRATIVE APPOINTMENTS: |
08/2014 - Present Director, Pediatric Infectious Diseases Residency Rotation |
Department of Pediatrics, Division of Infectious Diseases, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 |
HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS: |
None |
RESEARCH ADMINISTRATIVE APPOINTMENTS: |
None |
HOSPITAL STAFF PRIVILEGES: |
07/2009 - 06/2010 UPMC Mercy Hospital, 1400 Locust Street, Pittsburgh, PA |
07/2013 - 06/2014 Children's Hospital of Pittsburgh, One Children's Hospital Drive, 4401 Penn Avenue, Pittsburgh, PA |
08/2014 - Present Children's Wisconsin, 9000 W. Wisconsin Avenue, Milwaukee, WI |
08/2014 - Present Froedtert Memorial Lutheran Hospital, 9200 W. Wisconsin Avenue, Milwaukee, WI |
AWARDS AND HONORS: |
1997 - 2001 Dean's List, University of Wisconsin - Madison |
05/2001 - Present College of Agricultural & Life Sciences Senior Award |
06/2006 - Present Alpha Omega Alpha |
06/2009 - Present Pediatric Resident Award |
05/2012 - Present Pediatric Infectious Diseases Society Fellowship Award, Competitive, peer-reviewed selection process based on the applicant, mentor/environment, research plan, and potential for success as a clinical investigator in the field of pediatric infectious diseases |
10/2013 - Present Milstein Travel Award Recipient, International Cytokine & Interferon Society |
03/2016 - Present Department of Pediatrics Career Development Program Participant |
05/2017 - 2016 'Expert Clinician' in the Department of Pediatrics, Awarded annually to the top 10% of Department providers in recognition of Program Expansion, Clinical Scholarship and/or "Clinician's Clinician" sta, then chosen by peer voting |
05/2017 - 2016 'Expert Teacher' in the Department of Pediatrics, Awarded annually to the top 10% of Department faculty in recognition of overall teaching excellence, commitment to teaching learners, and dedication t, then chosen by peer and trainee voting |
08/2017 - Present NIH Pediatric Loan Repayment Program Recipient |
04/2018 - 2017 'Expert Teacher' in the Department of Pediatrics |
04/2018 - 2017 'Expert Clinician' in the Department of Pediatrics |
03/2019 - 2018 'Expert Teacher' in the Department of Pediatrics |
03/2019 - 2018 'Expert Clinician' in the Department of Pediatrics |
08/2019 - Present Best Doctors in America 2019-2020 |
01/2020 - 2019 'Expert Clinician' in the Department of Pediatrics |
11/2020 - Present MCW Outstanding Medical Student Teacher for 2019-2020, Teaching Pin Recipient |
05/2021 - 2020 'Expert Teacher' in the Department of Pediatrics |
06/2021 - 2020 'Expert Clinician' and 'Master Clinician' in the Department of Pediatrics, Awardees who have been named Expert Clinician for five consecutive years earn the title of Master Clinician. |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Journal Review |
05/2013 - Present Journal of the Pediatric Infectious Diseases Society |
05/2013 - Present JAIDS |
06/2013 - Present Pediatrics |
11/2014 - Present Cytokine |
06/2015 - Present Journal of Leukocyte Biology |
07/2015 - Present PLoS One |
05/2016 - Present Journal of Immunology |
01/2017 - Present International Journal of Molecular Sciences |
07/2017 - Present Experimental Lung Research |
07/2018 - Present Scientific Reports |
07/2018 - Present Hospital Practice |
10/2019 - Present Pediatric Infectious Diseases Journal |
05/2020 - Present Pediatric Transplantation |
07/2020 - Present Clinical Infectious Diseases |
11/2020 - Present Journal of Pediatric Hematology and Oncology |
01/2021 - Present Journal of Clinical Rheumatology |
04/2021 - Present Antibiotics |
05/2021 - Present Journal of Patient-Centered Research and Reviews |
LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
10/2014 - 02/2015 Clinical Advisory Team for Ebola Preparedness, Wisconsin Department of Public Health |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
11/2019 - Present Central Review Committee, International Pediatric Fungal Network DOMINIC Study |
10/2020 - Present Ad Hoc Reviewer, Team Science Grants, The Wellcome Trust/DBT India Alliance |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
National |
"Infectious Disease in Transplantation, " North American Transplant Coordinators Organization (NATCO) Introductory Course for the New Transplant Professional & Procurement Professional, Tempe, AZ, June 12, 2016 |
"Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis, " St. Jude/Pediatric Infectious Diseases Society Research Conference, Memphis, TN, February 21, 2014 |
"Infectious Disease in the Donor, " North American Transplant Coordinators Organization (NATCO) Introductory Course for the New Transplant Professional & Procurement Professional, Tempe, AZ, June 12, 2016 |
"Minimizing & Managing Post-Transplant Infections, " North American Transplant Coordinators Organization (NATCO) Introductory Course for the New Transplant Professional & Procurement Professional, Tempe, AZ, June 10, 2017 |
"Infectious Disease Assessment in the Organ Donor, " North American Transplant Coordinators Organization (NATCO) Introductory Course for the New Transplant Professional & Procurement Professional, Tempe, AZ, June 11, 2017 |
"Prevention and Management of Post-Transplant Infections, " North American Transplant Coordinators Organization (NATCO) Introductory Course for the New Transplant Professional & Procurement Professional, Tempe, AZ, November 3, 2018 |
"Infectious Disease Evaluation in the Organ Donor, " North American Transplant Coordinators Organization (NATCO) Introductory Course for the New Transplant Professional & Procurement Professional, Tempe, AZ, November 4, 2018 |
"Mycobiome and Invasive Fungal Infections, " Session Moderator, IDWeek 2019, Washington, DC, October 4, 2019 |
"Pre- and Post-Transplant Prevention and Treatment of Infections, " North American Transplant Coordinators Organization (NATCO) Introductory Course for the New Transplant Professional & Procurement Professional, Tempe, AZ, November 6, 2019 |
"Organ Donor and Infectious Disease Assessment, " North American Transplant Coordinators Organization (NATCO) Introductory Course for the New Transplant Professional & Procurement Professional, Tempe, AZ, November 7, 2019 |
Regional |
"Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis, " Fungal Supergroup Seminar Series, Madison, WI, November 21, 2013 |
"A Boy with Thrush: Review of CMC and STAT1 Mutations, " Joint Pediatric Immunodeficiency Conference (multicenter), Pittsburgh, PA, April 3, 2014 |
"Leveraging Immune Control of Candida to Combat Infection, " Lurie Children's Hospital of Chicago, Pediatric Infectious Diseases Special Seminar, Chicago, IL, January 23, 2019 |
Local |
"Triple Threat: Kingella kingae case presentation, " Infectious Diseases Grand Rounds, UPMC Presbyterian, Pittsburgh, PA, January 13, 2011 |
"Community-Acquired Pneumonia: Update on new guidelines, " Three Rivers Pediatric Update 2012, Pittsburgh, PA., May, 2012 |
"Lymphomatoid Granulomatosis: case presentation, " Infectious Diseases Grand Rounds, UPMC Presbyterian, Pittsburgh, PA, May 10, 2012 |
"Principles of Outbreak Investigation, " Fox Chapel Area Middle School Longitudinal Science Project, Pittsburgh, PA., January 28, 2013 |
"Vaccination in Pregnancy, " The Midwife Center for Birth & Women's Health. Pittsburgh, PA., February 4, 2013 |
"Multidrug resistant bacterial infection: case presentation, " Infectious Diseases Grand Rounds, UPMC Presbyterian, Pittsburgh, PA, April 4, 2013 |
"Red Book Update, " Three Rivers Pediatric Update 2013, Pittsburgh, PA., May 17, 2013 |
"Nontuberculous mycobacteria infection after stem-cell transplant: case presentation, " Infectious Diseases Grand Rounds, UPMC Presbyterian, Pittsburgh, PA, September 5, 2013 |
"Neutrophils in IL-17-dependent immunity to mucosal candidiasis, " Circle Seventeen Investigators, Pittsburgh, PA., October 9, 2013 |
"Vaccines: Tips and Tricks for promoting our greatest tools, " Three Rivers Pediatric Update 2014, Pittsburgh, PA, May 15, 2014 |
"IL-17 and neutrophils in defense from mucosal candidiasis, " Infectious Diseases Research Conference, Froedtert Hospital, April 16, 2015 |
"Challenges in the Management of ENT Infections, " Society of Otorhinolaryngology and Head Neck Nurses, Inc. 14th Annual Education Day, Milwaukee, WI, March 5, 2016 |
"Innate Immunity in Defense from Candida infections", Microbiology & Molecular Genetics Seminar Series, Medical College of Wisconsin, August 23, 2016 |
"Adult & Pediatric Vaccine Update, " Wisconsin Academy of Physician Assistants Fall Conference, Elkhart Lake, WI, October 13, 2016 |
"Can Host Defense from Candida Inspire Therapeutic Development?", Committee on Immunology's Annual Immunology Retreat, October 26, 2016 |
"Leveraging Immune Control of Candida to Combat Infection" Children's Research Institute Research Conference, December 16, 2016 |
"Infectious Disease", Ace the Boards, Medical College of Wisconsin/Department of Pediatrics Board Review Course, 2014, 2015, 2016, and 2017. |
"Adventures in Airborne Isolation, " Southeastern Wisconsin APIC Chapter Monthly Meeting, Milwaukee, WI, November 2, 2017 |
"Immunology. The Best Offense is a Good Defense, " Conversations with Scientists Lecture Series, Presented by the Medical College of Wisconsin and Advancing a Healthier Wisconsin Endowment, Milwaukee, WI, October 16, 2018. |
"K awards, " Medical College of Wisconsin Department of Pediatrics Grant Writing Retreat, Sheboygan, WI, March 8, 2019. |
"The Importance of Childhood Vaccines: What They Are and Why Your Child Needs Them, " Science Café in collaboration with CTSI, Milwaukee, WI, August 27, 2019. |
"The Importance of Childhood Vaccines: What They Are and Why Your Child Needs Them, " Science Café in collaboration with CTSI, Milwaukee, WI, August 26, 2020. |
"Neutrophils and Oropharyngeal Candidiasis, " Fungal Pathogen Meeting: Carnegie Mellon University, Pittsburgh, PA., November, 2011 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
National |
HUPPLER, A.R., Eickhoff, J.D., Wald, E.R. Performance of Low-Risk Criteria in the Evaluation of Young Infants with Fever: Review of the Literature. Infectious Diseases Society of America Annual Meeting, Philadelphia, PA, 2009. |
HUPPLER, A.R., Hernández-Santos, N., Darville, T., Gaffen, S.L. The IL-17-mediated regulation and role of neutrophils in resistance to oropharyngeal candidiasis. St Jude/PIDS Pediatric Infectious Diseases Research Conference, Memphis, TN, 2012. |
HUPPLER, A.R., Hernández-Santos, N., Darville, T., Gaffen, S.L. The IL-17/IL-23-mediated role of neutrophils in resistance to oropharyngeal candidiasis. Infectious Diseases Society of America Annual Meeting, San Diego, CA, 2012. • Oral Abstract Presentation |
HUPPLER, A.R., Hernández-Santos, N., Conti, H.R., Gaffen, S.L. The role of neutrophils in resistance to oropharyngeal candidiasis. Gordon Research Conference on Immunology of Fungal Infections, Galveston, TX, 2013. |
HUPPLER, A.R., Conti, H.R. Hernández-Santos, N., Gaffen, S.L. Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis. Meeting of the International Cytokine & Interferon Society, San Francisco, 2013. • Oral Abstract Presentation, Milstein Travel Award Recipient |
HUPPLER, A.R., Hernández-Santos, N., Conti, H.R., Gaffen, S.L. Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis. Gordon Research Conference on Immunology of Fungal Infections, Galveston, TX, 2015. |
He, J., Thomas, M.A., Grayson, M.H., Volkman, B.F., HUPPLER, A.R. CCL28 antimicrobial properties and defense from oropharyngeal candidiasis. 14th American Society for Microbiology Conference on Candida and Candidiasis, Providence, RI, 2018. • Oral Abstract Presentation |
Zembles, T.N., Kissell, A., Havens, P.L., Huppler, A.R. Assessment of a pharmacist-driven voriconazole clinical practice guideline in a children's hospital. IDWeek 2018, San Francisco, CA, 2018. |
He, J., Thomas, M.A., Grayson, M.H., Volkman, B.F., HUPPLER, A.R. CCL28 antimicrobial properties and defense from oropharyngeal candidiasis. Gordon Research Conference on Immunology of Fungal Infections, Galveston, TX, 2019. • Invited Speaker |
HUPPLER, A.R., He, J., Volkman, B.F., Grayson, M.H. An intact C-terminus is required for the antimicrobial effects of CCL28 in host defense from oropharyngeal candidiasis. Immunology, Seattle, 2016. • Oral Abstract Presentation |
Local |
HUPPLER, A.R., Hernández-Santos, N., Conti, H.R., Gaffen. S.L. Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis. Committee on Immunology Conference, Blood Center of Wisconsin, Milwaukee, WI, 2014. |
HUPPLER, A.R., Hernández-Santos, N., Darville, T., Gaffen, S.L. The IL-17-mediated regulation and role of neutrophils in resistance to oropharyngeal candidiasis. University of Pittsburgh Department of Medicine Research Day, Pittsburgh, PA, 2012. |
HUPPLER, A.R., Hernández-Santos, N., Conti, H.R., Gaffen. S.L. CXCR2 and myeloid cells are essential to host defense from oropharyngeal candidiasis. University of Pittsburgh Department of Medicine Research Day, Pittsburgh, PA, 2013. |
HUPPLER, A.R., Conti, H.R., Hernández-Santos, N., Gaffen, S.L. CXCR2 and myeloid cells participate in host defense from oropharyngeal candidiasis. 3rd Annual Rangos Research Symposium, Pittsburgh, PA, 2013. Award finalist |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
08/2014 - Present Infection Control Committee, Children's Wisconsin, Ad hoc chair during absence of the permanent chair, including coverage during major infection prevention events, such as nosocomial varicella exposures |
08/2014 - Present Antimicrobial Stewardship Program, Children's Wisconsin, Ad hoc advisor to pharmacists, collaborator for multiple clinical improvement projects |
06/2015 - 10/2015 Pediatric Fellowship Funding Committee, Medical College of Wisconsin |
02/2016 - 01/2017 Pediatric Infectious Diseases Division Chief Search Committee |
02/2019 - Present Critically Immunocompromised Patient Committee |
09/2020 - Present Institutional Biosafety Committee |
MCW TEACHING ACTIVITIES: |
Medical Student Education |
03/2016 - Present Lecturer, Mycology, Infectious Agents and Host Immunity Course |
08/2017 - Present Preceptor, Case-Based Discussions, Molecules to Cells Course |
Graduate Student Education |
10/2014 - 09/2018 Poster Judge for Graduate School of Biomedical Sciences and Office of Postdoctoral Education Annual Research Poster Day |
03/2016 - 08/2020 Instructor, Mucosal Immunology Course |
10/2018 - 11/2019 Lecturer, Immune Responses to Fungi & Integrated Paper Discussion, Cellular and Molecular Immunology Course |
Resident and Fellow Education |
08/2014 - Present SurfBoards series presenter, Pediatric Resident Board Review |
08/2014 - Present Adult Infectious Diseases Fellow Teaching, Pediatric Infectious Diseases Rotation |
09/2014 - 05/2015 Series Presenter, Joint Pediatric-Adult Infectious Diseases Case Conference |
12/2014 - Present Presenter, Fungal Infections, Pediatric Resident Noon Conference |
12/2014 - Present Presenter, Parasitic Infections, Pediatric Resident Noon Conference |
01/2015 - 02/2019 Faculty facilitator, Intern Morning Report |
12/2016 - Present Invited speaker, Cytomegalovirus and Liver Disease, GI Fellowship Liver Education Series |
03/2018 - Present Invited speaker. Unusual Liver Infections, GI Fellowship Liver Education Series |
04/2018 - Present Invited speaker, Fungal Infections, Critical Care Fellowship Education Series |
11/2018 - Present Invited speaker, Infectious Diseases Topics, Emergency Medicine Fellowship Education Series |
12/2018 - Present Invited speaker, Cytomegalovirus, GI Fellowship Liver Education Series |
03/2019 - Present Faculty facilitator, Senior Resident Rounds |
06/2020 - Present Invited speaker, Fungal Infections: Diagnostic and Therapeutic Considerations, Critical Care Education Series |
09/2020 - Present Invited speaker, Infections of the Liver, GI Fellowship Liver Education Series |
11/2020 - Present Invited speaker, CNS infections, Emergency Medicine Fellowship Education Series |
04/2021 - Present Invited speaker, Fever of Unknown Origin, Hospital Medicine Fellowship Education Series |
Continuing Medical Education |
08/2014 - 08/2017 Presenter, Infections Diseases, Ace the Boards, Pediatric Board Review Course |
08/2015 - Present Invited speaker, Fever of Unknown Origin, Hospital Medicine Division Professional Development Series |
09/2019 - Present Invited speaker, Fever of Unknown Origin: joint ID/Rheumatology presentation, Hospital Medicine Division Professional Development Series |
Community/Lay Public |
10/2018 - Present Invited speaker, Conversations with Scientists Lecture Series, Medical College of Wisconsin and Advancing a Healthier Wisconsin Endowment
|
08/2019 - Present Invited discussion leader, Science Café in collaboration with CTSI |
08/2020 - Present Invited discussion leader, Science Café in collaboration with CTSI |
10/2020 - Present Interview Guest, Program on Vaccinations, CTSI Discovery Radio |
EXTRAMURAL TEACHING: |
Continuing Medical Education |
03/2016 - Present Invited speaker, ENT Infections, ENT Nurses Annual Education Day |
06/2016 - Present Invited speaker, Infectious Diseases in Transplantation and Infectious Disease in the Donor, North American Transplant Coordinators Organization Annual Introductory Course |
10/2016 - Present Invited speaker, Vaccines, Wisconsin Academy of Physician Assistants Fall CME Conference |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Medical Students |
11/01/2014 - 06/01/2017 Erin Myers, Pathway Mentor, MCW, Making Health Literacy Child’s Play, featured pathway poster |
04/01/2016 - 07/01/2016 Alyssa Colby, Clinical Shadowing Experience, MCW |
05/01/2016 - Present Lauren Barta, Clinical Shadowing Experience, MCW |
11/2016 - 06/2020 Kevin Schlidt, Pathway Mentor, MCW, IDweek poster |
12/2016 - Present Zoe Morgan, Clinical Shadowing Experience, MCW |
08/2017 - 10/2020 Nisreen Mobayed, Research Project Mentor, MCW, IDweek poster |
11/2017 - Present Samantha Lauhon, Pathway & Research Project Mentor, MCW, ATC and PAS posters |
11/2017 - 04/2021 Sarah Park, Research Project Mentor, MCW, PAS poster |
03/2021 Jenna Cormier, Clinical Shadowing Experience, MCW |
06/2021 - Present Rachel Weber, Clinical Shadowing Experience, MCW |
Clinical/Research Fellows |
11/2016 - 06/2019 Lauren Pommert, Scholarship Oversight Committee Member, MCW |
07/2017 - 06/2018 Ranjeet Minocha, Scholarship Oversight Committee Member, MCW |
06/2018 - 06/2020 Brian Carroll, Scholarship Oversight Committee Member, MCW |
11/2020 - Present Brittany Player, Project Mentor and Scholarship Oversight, MCW |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Residents |
10/2017 - 06/2020 Jaimee Hall, Residency Advisor and Research Mentor, CHW, Publication, ID fellow |
07/2018 - 06/2020 Nina Morgan, Residency Advisor, CHW |
07/2020 - Present Brittany Lehrer, Research Mentor, CHW, ID fellowship |
08/2020 - Present Joana Dimo, Research Mentor, CHW, Abstract at national meeting, MCW QI award |
08/2020 - Present Charlotte Formeller, Residency Advisor, CHW |
10/2020 - Present Natalia Beneschott, Quality Improvement Project Mentor, CHW |
07/2021 - Present Andy Vega, Residency Advisor, CHW |
PROGRAMMATIC DEVELOPMENTS: |
Educational Programs |
Resident |
09/2015 - 06/2017 Pager Communication QI project, Project Team Member |
10/2020 - Present Asplenia Vaccine QI project, Faculty mentor |
Faculty |
02/2015 - 12/2018 Clinical Practice Guidelines Author- Febrile Neonate |
09/2015 - 01/2019 Clinical Practice Guidelines Advisor- Community Acquired |
04/2016 - Present Clinical Practice Guidelines Author- Osteomyelitis and Septic Arthritis |
Pneumonia with Pleural Effusion |
Research Programs |
11/2015 - 11/2017 Persistent CSF HSV Study site PI |
02/2016 - Present International Pediatric Fungal Network site PI |
02/2017 - 02/2018 Anidulafungin Pediatric Study site co-PI |
10/2019 - Present Live-Viral Vaccination after Pediatric Transplantation site co-I |
Multicenter observational study to understand safety, efficacy, and |
Collaborative group of investigators and centers focused on pediatric invasive fungal infections. |
immunogenicity of live viral vaccination after liver or kidney transplant. |
Clinical Programs |
09/2014 - 03/2018 Antimicrobial Lock Therapy Protocol Development |
10/2014 - Present Cardiac Transplant Infectious Diseases Advisor |
01/2016 - Present Voriconazole CPG Process Evaluation |
05/2018 - 06/2021 Improving vaccination rates after liver transplant- Quality Improvement Project |
08/2019 - Present Improving endocarditis specimen handling and order entry- Quality Improvement Project |
01/2021 - Present Childhood Vaccination Disparity Project |
Expanded treatment options for central-line associated infections at CHW, including education of providers and staff, creation of pharmacy and EMR protocols, and committee approvals. |
Develop evidence-based protocols, supply monthly program support, provide transplant ID advice, initiated routine ID involvement in pre-transplant evaluations. |
Community Programs None |
COMMUNITY SERVICE ACTIVITIES: |
09/2014 - 05/2016 Saint Jude Church Choir Member |
06/2021 - Present Volunteer, Saint John Vianney School |
SPECIALTY BOARDS AND CERTIFICAITONS:: |
10/01/2009 - 12/01/2023 American Board of Pediatrics- General Pediatrics |
11/01/2013 - 12/01/2023 American Board of Pediatrics- Infectious Diseases |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. HUPPLER, A.*, Nikstad L.J.*, Allmann A.M., Brow D.A., Butcher S.E..: Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure. Nat Struct Biol 9:431-5, 2002. PMID 11992125. *Authors contributed equally |
2. Wang, Y., Kedei, N., Wang, M., Wang, Q.J., HUPPLER, A.R., Toth, A., Tran, R., Blumberg, P.M.: Interaction between protein kinase Cmu and the vanilloid receptor type 1. J Biol Chem 279:53674-82, 2004. PMID 15471852. |
3. Lu, G., Chen, J., Espinoza, L.A., Garfield, S., Toshiyuki, S., Akiko, H., HUPPLER A., Wang Q.J.: Protein kinase D 3 is localized in vesicular structures and interacts with vesicle-associated membrane protein 2. Cell Signal19:867-79, 2007. PMID 17196367. |
4. HUPPLER, A.R., Eickhoff, J.C., Wald, E.R..: Performance of Low-Risk Criteria in the Evaluation of Young Infants With Fever: Review of the Literature. Pediatrics 125:228-233, 2010. PMID 20083517. |
5. Hernández-Santos, N., HUPPLER, A.R., Peterson, A.C., Khader, S.A., McKenna, K.C., Gaffen, S.L.: Th17 cells confer long term adaptive immunity to oral mucosal Candida albicans infections. Mucosal Immunol 6(5):900-10, Sept., 2013. PMID 23250275. |
6. Bishu, S., Hernández-Santos, N., Simpson-Abelson, M.R., HUPPLER, A.R., Conti, H.R., Ghilardi, N., Mamo, A., Gaffen, S.L.: The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections. Infect Immun 82(3):1173-80, March 2014. PMID 24379290. |
7. HUPPLER, A.R., Conti, H.R., Hernández-Santos, N., Darville , T., Biswas, P., Gaffen, S.L.: Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis. J Immunol 192(4):1745-52, Feb. 15, 2014 PMID 24442441. |
8. Conti, H.R., HUPPLER, A.R., Whibley, N, Gaffen, S.E.: Animal models for candidiasis. Curr Protoc Immunol. 105:19.6.1-19.6.17, Apr 2, 2014. PMID 24700323. |
9. Ramani, K., Pawaria, S., Maers, K., HUPPLER, A.R., Gaffen, S.L., Biswas, P.S.: An essential role of interleukin-17 receptor signaling in the development of autoimmune glomerulonephritis. J Leukoc Biol. 96(2);463-72. Sept, 2014. PMID 24935958. |
10. Conti, H.R., Peterson, A.C., Brane, L., HUPPLER, A.R., Hernández-Santos, N., Whibley, N., Garg, A.V., Simpson-Abelson, M.R., Gibson, G.A., Mamo, A.J., Osborne, L.C., Bishu, S., Ghilardi, N., Siebenlist, U., Watkins, S.C., Artis, D., McGeachy, M.J., Gaffen, S.L.: Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections. J Exp Med.211(10):2075-84. Sept 22, 2014. PMID 252000028. |
11. HUPPLER, A.R., Verma, A.H., Conti, H.R., Gaffen, S.L.: Neutrophils Do Not Express IL-17A in the Context of Acute Oropharyngeal Candidiasis. Pathogens. 4(3):559-72. Jul 24, 2015. PMID 26213975. |
12. HUPPLER, A.R., Whibley, N., Woolford, C.A., Childs, E.E., He, J., Biswas, P.S., McGeachy, M.J., Mitchell, A.P., Gaffen, S.L.: A Candida albicans strain expressing mammalian IL-17A results in early control of fungal growth during disseminated infection. Infect Immun. 2015 Sep;83(9):3684-92. PMID 26150537. |
13. Zembles, T.N., Thompson, N.E., Havens, P.L., Kaufman, B.A., HUPPLER, A.R.: An Optimized Voriconazole Dosing Strategy to Achieve Therapeutic Serum Concentrations in Children Younger Than 2 Years Old. Pharmacotherapy. 2016 Oct;36(10):1102-1108. PMID 27548272. |
14. Verma, A.H., Richardson, J.P., Zhou, C., Coleman, B.M., Moyes, D.L., Ho, J., HUPPLER, A.R., Ramani, K., McGeachy, M.J., Mufazalov, I., Kane, L.P., Biswas, P.S., Hube, B., Naglik, J.R., Gaffen, S.L.: Oral epithelial cells orchestrate innate type 17 responses to Candida albicans via the virulence factor candidalysin. Science Immunol. 2017 Nov 3;2(17). PMID 29101209. |
15. Zembles, T.N., Flannery, L.S., Huppler, A.R.: Development and implementation of an antimicrobial lock guideline in a pediatric hospital. Am J Health Syst Pharm. 2018 Mar 1;75(5):299-303. PMID 29472511. |
16. Thomas, M.A., He, J., Peterson, F.C., Huppler, A.R., Volkman, B.F.: The Solution Structure of CCL28 Reveals Structural Lability that Does Not Constrain Antifungal Activity. J Mol Biol. 2018 Sep 14;;430(18 Pt B):3266-3282. PMID 29913161. |
17. Erker, C., HUPPLER, A.R., Walsh, T.J., McCormick, M.E., Suchi, M., Bhatt, N.S., Kehl, S.C., Southwood, J., Harker-Murray, P.: Successful Treatment of Invasive Conidiobolus Infection During therapy for Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2018 Oct;40(7):e446-e449. PMID 28991126. |
18. Claeys, T.A., Rosas Mejia, O., Marshall, S., Jarzembowski, J.A., Hayes, D., Hull, N.M., Liyanage, N.P.M., Chun, R.H., Sulman, C.G., Huppler, A.R., Robinson, R.T.: Attenuation of Helper T Cell Capacity for TH1 and TH17 Differentiation in Children with Nontuberculous Mycobacteria Infection. J Infect Dis. 2019 Oct 22;220(11):1843-1847. PMID 31332447. |
19. Peters, B.M., Coleman, B.M., Willems, H.M.E., Barker, K.S., Aggor, F.E.Y., Cipolla, E., Verma, A.H., Bishu, S., Huppler, A.H., Bruno, V.M., Gaffen, S.L.: The IL-17R/IL-22R signaling axis is dispensable for vulvovaginal candidiasis regardless of estrogen status. J Infect Dis. 2019 Dec 5. PMID 31805183. |
20. Dishman, A.F., Lee, M.W., de Anda, J., Lee, E.Y., He, J., Huppler, A.R., Wong, G.C.L., Volkman, B.F.: Switchable Membrane Remodeling and Antifungal Defense by Metamorphic Chemokine XCL1. ACS Infect Dis. 2020 Apr 15. PMID 32243126. |
21. He, J., Thomas, M.A., de Anda, J., Lee, M.W., Van Why, E., Simpson, P., Wong, G.C.L., Grayson, M.H., Volkman, B.F., Huppler, A.R.: Chemokine CCL28 is a potent therapeutic agent for oropharyngeal candidiasis. Antimicrob Agents Chemother. 2020 Jul 22;64(8):e00210-20. PMID 32423961. |
22. Jondle, C.N., Johnson, K.E., Aurubin, C., Sylvester, P., Xin, G., Cui, W., Huppler, A.R., Tarakanova, V.L. Gammaherpesvirus Usurps Host IL-17 Signaling To Support the Establishment of Chronic Infection. mBio. 2021 Apr 6;12(2):e00566-21. PMID 33824206. |
23. Hall, J.M., Havens, P.L., Mitchell, E.A., De Vela, G.N., Titus, L.L., Dasgupta, M., Simpson, P.M., Kehl, S.C., Willoughby, R.E., Henrickson, K.J., Mitchell, M.L., Huppler, A.R., Chusid, M.J.. Blastomycosis in 64 Wisconsin Children: Unanticipated Infection Risk and Severity in Urban Residents. Pediatr Infect Dis J. 2021 May 7. PMID 33990518. |
24. Dishman, A.F., He, J., Volkman, B.F., Huppler, A.R. Metamorphic protein folding encodes multiple anti-Candida mechanisms in XCL1. Pathogens. 2021 Jun 17;10(6)762. PMID 34204234. |
25. Gumm, A.J., Lerret, S., Zeman, M., Rueter, J., Huppler, A.R., Khan, Z., Telega, G., Vitola, B. Quality Improvement Project to Improve Vaccinations in the Pediatric Liver Transplant Population. Pediatric Transplantation. 2021 Jun 29:e14076. PMID 34185930. |
26. Fisher B.T., Zaoutis T.E., Xiao R., Wattier R.L., Castagnola E., Pana Z.D., Fullenkamp A., Boge C.L.K., Ross R.K., Yildirim I., Palazzi D.L., Danziger-Isakov L., Vora S.B., Arrieta A., Yin D.E., Avilés-Robles M., Sharma T., Tribble A.C., Maron G., Berman D., Green M., Sung L., Romero J., Hauger S.B., Roilides E., Belani K., Nolt D., Soler-Palacin P., López-Medina E., Muller W.J., Halasa N., Dulek D., Hussain I.Z.B., Pong A., Hoffman J., Rajan S., Gonzalez B.E., Hanisch B., Aftandilian C., Carlesse F., Abzug M.J., Huppler A.R., Salvatore C.M., Ardura M.I., Chakrabarti A., Santolaya M.E., Localio A.R., Steinbach W.J. Comparative Effectiveness of Echinocandins vs Triazoles or Amphotericin B Formulations as Initial Directed Therapy for Invasive Candidiasis in Children and Adolescents. J Pediatric Infect Dis Soc. 2021 Aug 10. PMID 34374424. |
Books, Chapters, and Reviews |
1. HUPPLER, A.R., Bishu, S., Gaffen, S.L.: Mucocutaneous Candidiasis: implications for targeted immunotherapy. Arthritis Res Ther 14(4):217, 2012. PMID 22838497. |
2. Robinson, R.T., HUPPLER, A.R.: The Goldilocks model of immune symbiosis with Mycobacteria and Candida colonizers. Cytokine 2017 Sep;97:49-65. PMID 28570933. |
3. HUPPLER, A.R., Fisher, B.T., Lehrnbecher, T., Walsh, T.J., Steinbach, W.J.: Role of Molecular Biomarkers in the Diagnosis of Invasive Fungal Diseases in Children. J Pediatr Infect Dis Soc. 2017 Sep 1;6(suppl_1):S32-S44. PMID 28927202. |
4. Mohandas, S., Gregory, S., Chun, R.H., HUPPLER, A.R.: Pediatric deep neck space infections: a medical and surgical perspective. J Pediatr Infect Dis. 2019 Feb;14(2):043-051. |
5. HUPPLER, A.R. Infectious Complications of HSCT. Nelson Textbook of Pediatrics, 21st ed. Robert Kliegman, Joseph St. Geme, Ed. Elsevier. 2019. |
6. HUPPLER, A.R. Fever. Nelson Pediatric Symptom-Based Diagnosis: Common Disorders and Their Mimics, 2nd ed. Robert Kliegman, Brett Bordini, Donald Basel, Heather Toth. Elsevier. 2022. In revision. |
Editorials, Letters To Editor, Other |
1. HUPPLER, A.R., Gaffen, S.L.: Editorial: Fake it 'til you make it: mast cells acquire IL-17 exogenously. J Leukoc Biol. 2016 Sep;100 (3): 445-46. PMID 27587375. |
Abstracts |
1. Wang, Y., Kedei, N., Wang, M., Wang, Q.J., HUPPLER, A.R., Toth, A., Tran, R., Blumberg, P.M.: The interaction between PKCmu and the vanilloid receptor VR1. Society for Neuroscience, Orlando, FL, 2002. |
2. Hernández-Santos, N., Peterson, A.C., HUPPLER, A.R., Khader, S.A., McKenna, K.C., Gaffen, S.L. Cellular mediators of long-term protective immunity to Candida albicans in oropharyngeal candidiasis. American Society of Microbiology Candida and Candidiasis Conference, San Francisco, CA, 2012. |
3. Conti, H.R., Peterson, A.C., Herrnández-Santos, N., HUPPLER, A.R., Bishu, S., Gaffen, S.L. Innate CD3+ CD4- CD8- Lymphocytes important in acute oropharyngeal candidiasis. Gordon Research Conference on Immunology of Fungal Infections, Galveston, TX, 2013. |
4. Hernández-Santos, N., HUPPLER, A.R., Peterson, A.C., Khader, S.A., McKenna, K.C., Gaffen, S.L. Th17 cells confer long-term adaptive immunity to Oropharyngeal Candidiasis. Gordon Research Conference on Immunology of Fungal Infections, Galveston, TX, 2013. |
5. Hernández-Santos, N., HUPPLER, A.R., Peterson, A.C., Khader, S.A., McKenna, K.C., Gaffen, S.L. Th17 cells confer long-term adaptive immunity to Oropharyngeal Candidiasis. Immunology 2013, Honolulu, HI, 2013. |
6. Bishu, S., Hernández-Santos, N., Simpson-Abelson, M.R., HUPPLER, A.R., Conti, H.R., Ghilardi, N., Mamo, A., Gaffen, S.L.: The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections. Immunology 2014, Pittsburgh, PA. |
7. Conti, H., Peterson, A., Hernández-Santos, N., Brane, L., HUPPLER, A., Whibley, N., Hamilton, K., Garg, A., Bishu, S., Simpson-Abelson, M., Mamo, A.J., Artis, D., Thomson, A., Watkins, S., McGeachy, M., Gaffen, S. "Natural" Th17 cells control Candida albicans infections in the oral mucosa. Immunology 2014, Pittsburgh, PA. |
8. Biswas, P., Ramani, K., Maers, K., HUPPLER, A., Gaffen, S.L. Neutralization of IL-17 Ameliorated Kidney Pathology Associated with Immune-Complex Mediated Autoimmune Glomerulonephritis. American College of Rheumatology Annual Meeting, Boston, MA, 2014. |
9. Erker, C., Huppler, A., Walsh, T., Bhatt, N., Harker-Murray, P. Invasive Conidiobolus Infection: Management during Induction Therapy for Acute Lymphoblastic Leukemia. American Society of Pediatric Hematology/Oncology, Minneapolis, MN, 2016. |
10. Jondle, C.N., Johnson, K.E., Aurubin, C., Sylvester, P., Xin, G., Huppler, A.R., Tarakanova, V.L. A novel proviral function for IL-17 during gammaherpesvirus infection. Immunology 2019, San Diego, CA, 2019. |
11. Gumm, A.J., Lerret, S., Zeman, M., Hogan, J., Huppler, A.R., Telega, G., Vitola, B. Live Vaccines for Pediatric Liver Transplant Recipients: A Quality Improvement Project. 24th Annual Society of Pediatric Liver Transplantation 2019 annual Conference, Houston, TX, 2019. |
12. Hahn, D., Mobayed, N., Schlidt, K., Simpson, P., Huppler, A.R. Osteoarticular Infections in Children: A Case for a Disease-Specific Antibiogram and Implications for Treatment., Pediatric Hospital Medicine Meeting, Orlando, FL, 2020. (meeting cancelled due to COVID-19 pandemic). |
13. Coleman, B.M., Peters, B.M., Willems, H.M.E., Barker, K.S., Aggor, F.E.Y., Cipolla, E., Verma, A.H., Bishu, S., Huppler, A.H., Bruno, V.M., Gaffen, S.L. IL17 and Candida albicans colonization in the vaginal mucosa. Immunology 2020 (meeting cancelled due to COVID-19 pandemic). |
14. He, J., Volkman, B.F., Grayson, M.H., HUPPLER, A.R. Anti-Candida activity of CCL28 in oropharyngeal candidiasis. Committee on Immunology Conference, Blood Center of Wisconsin, Milwaukee, WI, 2015. Poster Presentation. |
15. He, J., Thomas, M.A., Grayson, M.H., Volkman, B.F., HUPPLER, A.R. CCL28 acts as an antimicrobial peptide in host defense from OPC through an IL-23/Il-17 dependent pathway, Committee on Immunology- Annual Immunology Retreat, Blood Center of Wisconsin, Milwaukee, WI, 2016. Poster Presentation. |
16. He, J., Thomas, M.A., Grayson, M.H., Volkman, B.F., HUPPLER, A.R. Optimization of antifungal efficacy of CCL28 peptide in mouse oropharyngeal candidiasis model. Committee on Immunology- Annual Immunology Retreat, Blood Center of Wisconsin, Milwaukee, WI, 2017. Poster Presentation. |
17. He, J., Thomas, M.A., Grayson, M.H., Volkman, B.F., HUPPLER, A.R. CCL28 antimicrobial properties and defense from oropharyngeal candidiasis. Committee on Immunology- Annual Immunology Retreat, Blood Center of Wisconsin, Milwaukee, WI, 2018. Poster Presentation. |
18. Mobayed N., Schlidt K., Roadman, D., Hahn, D., Huppler, A.R. Septic Arthritis and Acute Hematogenous Osteomyelitis in Children: Disease-Specific Antibiogram and Implications for Treatment. IDWeek 2019, Washington D.C., 2019. Poster Presentation. |
19. He, J., Thomas, M.A., Van Why E., Grayson, M.H., Volkman, B.F., HUPPLER, A.R. Chemokine CCL28 treats oropharyngeal candidiasis through rapid membrane disruption. Immunology 2020, Honolulu, HI, 2020 |
20. Lauhon, S.R., Stendahl, G., Kindel, S.J., Punnoose, A.R., Huppler, A.R. Impact of Infectious Disease Intervention on Vaccine Compliance in Pediatric Heart Transplant Patients. American Transplant Congress 2020, Philadelphia, PA, 2020 Poster Presentation. (virtual meeting due to COVId-19 pandemic) |
21. Lauhon, S.R., Stendahl, G., Kindel, S.J., Punnoose, A.R., Huppler, A.R. Impact of Infectious Disease Intervention on Vaccine Compliance in Pediatric Heart Transplant Patients. Pediatric Academic Societies Meeting, Philadelphia, PA, 2020 (meeting canceled due to COVID-19 pandemic). |
22. Park, S., Pollow, A., Kindel, S.J., Huppler, A.R., Punnoose, A.R. Antiviral prophylaxis protocol implementation in pediatric cardiac transplant. Pediatric Academic Societies Meeting, Philadelphia, PA, 2020 (meeting canceled due to COVID-19 pandemic). |
23. Hall J.M., Havens P.L., Mitchell E.A., De Vela G.N., Titus L.L., Dasgupta M., Simpson P.M., Kehl S.C., Willoughby R.E., Henrickson K.J., Mitchell M.L., Huppler A.R., Chusid M.J. Blastomycosis in 64 Wisconsin Children: Unanticipated Infection Risk and Severity in Urban Residents. PIDS St. Jude Conference, 2021. Virtual Poster Presentation. |
24. Dimo, J., Hahn, D., Huppler, A.R. Use of Clinical Practice Guideline to Improve Management of Septic Arthritis and Acute Hematogenous Osteomyelitis in Children. Pediatric Hospital Medicine Conference, 2021. Virtual Poster Presentation. |
Patents |
1. United States Patent: 10.160.974, granted on December 25, 2018. Gaffen, S.L., McGeachy, M.J., HUPPLER, A.R., Mitchell, A.P. University of Pittsburgh and Carnegie Mellon University. Engineered cytokine- and chemokine-expressing Candida albicans strains and methods of use. |
