CURRICULUM VITAE
Ashraf El-Meanawy MD, PhD
Ashraf El-Meanawy MD, PhD
Professor
Department of Medicine
Division of Nephrology
Department of Medicine
Division of Nephrology
OFFICE ADDRESS: |
Health Research Center |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
EDUCATION: |
07/1987 - 10/1990 MD & PhD Medicine/Surgery Biochemistry & Molecular Biology, Cairo University, Cairo, Egypt |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
04/1991 - 12/1993 Post Doctoral Fellow, Molecular and Microbiology, Case Western Reserve University, Cleveland, OH |
01/1994 - 12/1996 Resident, Internal Medicine, Case Western Reserve University, Cleveland, OH |
01/1997 - 06/1999 Clinical Instructor (NIH Grant, Nephrology Research), Case Western Reserve University, Cleveland, OH |
07/2003 - 09/2006 Nephrology Fellow, Nephrology, Case Western Reserve University, Cleveland, OH |
FACULTY APPOINTMENTS: |
07/1999 - 08/2007 Assistant Professor of Medicine, Case Western Reserve University, OH, Nephrology Division, Cleveland |
09/2007 - 06/2013 Assistant Professor of Medicine, Medical College of Wisconsin, WI, Nephrology Division, Milwaukee |
02/2013 - Present Associate Professor of Medicine, Medical College of Wisconsin, WI, Nephrology Division, Milwaukee |
07/01/2019 - Present Professor of Medicine, Medicine, Nephrology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226 |
ADMINISTRATIVE APPOINTMENTS: |
09/2007 - Present Froedtert Memorial Lutheran Hospital, Milwaukee, Wisconsin |
07/2009 - Present Zablocki VA Medical Center, Milwaukee, Wisconsin |
03/2013 - Present Community Memorial Hospital, Menomonie Falls, Wisconsin |
06/2014 - Present Director of outpatient Dialysis, Medical College of Wisconsin |
06/2014 - Present Medical Director, FMC center point dialysis center |
06/2014 - Present Medical Director, Home dialysis program, FMC |
06/2014 - Present Director of inpatient dialysis, MCW associated hospitals |
06/2018 - Present Medical Director, FMC Brookfield, dialysis center |
CURRENT HOSPITAL STAFF PRIVILEGES: |
AWARDS AND HONORS: |
1990 - Present Young Scientist Award, Schistosomiasis Research Project (US-AID) |
1993 - Present Resident research award, Case Western Reserve / MetroHealth |
1995 - 1996 Pharmacy and Therapeutic Committee, MetroHealth Medical Center |
1998 - Present American Society of Nephrology |
2001 - 2007 PDA Advisory Committee, MetroHealth Medical Center |
2001 - 2007 Information Services Advisory Committee, MetroHealth Medical Center, Rammelkamp Center for Research |
2011 - 2014 European Renal Association/EDTA |
2011 - 2014 IRB, Medical College of Wisconsin |
2012 - Present American Physiologic Society |
2013 - Present Featured New Investigator Award, Central Society of Clinical Research, CSCR |
2013 - Present Research and Development Committee, Milwaukee VA Medical Center. |
2013 - 2015 Medicine IT committee, Medical College of Wisconsin |
2014 - Present Presnet System inpatient platform committee, Froedtert Health, Milwaukee, WI. |
2014 - 2017 Diversity and Inclusion Advisory Committee (DIAC), MCW |
2014 - Present Director of outpatient dialysis, Medical College of Wisconsin. |
2014 - Present Director of inpatient dialysis, Medical College of Wisconsin Associated Hospitals. |
2014 - 2017 Research Committee, Medical College of Wisconsin. |
2015 - 2018 Faculty Council elected member, Medical College of Wisconsin. |
2015 - Present Board of director, National Kidney Foundation, Wisconsin chapter. |
2017 - Present Platinum Most valuable member, ASN communities |
2018 - Present Fellow of the American Society of Nephrology |
2019 - Present Named Nephrotic Syndrome Expert, by NephCure Kidney International |
PROFESSIONAL MEMBERSHIPS |
LOCAL/REGIONAL LEADERSHIP AND COMMITTEE POSITIONS: |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorial Board |
2014 - Present Presnet PLOS1 |
2015 - Present Journal of Clinical Investigation-Insight |
2016 - Present International Journal of Nephrology |
2018 - Present Frontiers in Physiology |
2018 - Present Clinical Transplantation |
2018 - Present American Journal of Renal Physiology |
Journal Reviewer |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
- Leuven University, Belgium, 05/2012 - Present |
National |
- Kidney Institute, Kansas University, 04/2010 - Present |
- Baylor school of Medicine, Houston, - 09/2018 |
- Keck school of Medicine, University of southern CA 11/2018: Title: "A new era for ultrasound, Identifying nephron deficiency and risk for kidney disease progression" |
- Keynote speaker, Versiti retreat, Zion, - 05/2018 |
- University of Wisconsin, Madison, WI 3/2016: Title: "Nephron Number, Kidney Disease, Hypertension, and Tales from the Womb" |
- NephCure, Chicago, IL 4/2015: Title "FSGS Disease Overview and Nephrotic Syndrome Considerations, Presentation, and Prognosis" |
- CSCTR/MMAFR meeting invited speaker. Chicago, IL 4/2013. Title "Nephron Adequacy, Prematurity, and Tales from the Womb". |
- Loma Linda University and Loma Linda VA Medical Center, 11/2011. Title "The Fateful Trihedron; Nephron Adequacy, Hypertension and Kidney Disease" |
Local |
-Medicine Grand Rounds, Froedtert and the Medical College of Wisconsin, 01/2008 - Present |
-Medicine Grand Rounds: Froedtert and the Medical College of Wisconsin, 01/2013 - Present |
- Concordia University, WI, 10/2015 - Present |
-Medicine Grand Rounds: Froedtert and the Medical College of Wisconsin, 05/2011. Title "Nephron Number, Hypertension and Kidney Disease: Late Manifestation of an Early Problem" |
-Medicine Grand Rounds, Clement J Zablocki VA Medical Center, 05/2010. Title "Vitamin D; For Calcium, Bone, and Beyond" |
-Medicine Grand Rounds, Clement J Zablocki VA Medical Center, Milwaukee, WI 02/2014. Title "Amyloidosis, Not So Uncommon" |
- Children Research Institute, Milwaukee, WI 9/2015: Title "Prematurity, Perinatal Environment, Nephron number and adult kidney Disease". |
TEACHING ACTIVITIES: |
Harvard School of Tropical Medicine and Hygiene: |
1992 |
Course title: "Biology of Parasitism" |
Case Western Reserve University: |
2005-2006 |
Course title: "First-year renal physiology course" |
Small group conferences teaching GFR and Tubular Function, Na+, K+, and Water Handling, Volume Homeostasis, Acid-Base, and Fluid and Electrolyte Balance |
Medical College of Wisconsin: |
2008 |
Course title: "Clinical Examination and Reasoning" |
2014 |
Course title: Discovery Curriculum; "Chronic Kidney Disease" |
and manuscript in preparation number 27. |
Course title Renal Physiology for graduate students |
COMMUNITY AND VOLUNTEER SERVICE: |
2008 - 2011 Volunteer Soccer coach for Brookfield Soccer Association |
2009 - CKD Screening, National Kidney Foundation. |
2012 - Saturday Clinic for the Un-insured (Milwaukee WI) |
2010 - 2011 Patient educational seminars, Polycystic Kidney Disease (PKD) Foundation |
MENTEES: |
Current: |
Daniel Fahernbach Graduate student, physiology. 2018-current. PhD Committee Member. |
Andrew Maike Nephrology fellow. 2019-current. Fellow research project |
Previous: |
Aoron Sop Chester scholar student at MetroHealth Center, Case Western Reserve |
University. 1997. Orthopedic surgeon. |
Fatima Pozuelo Research rotation, Case Western Reserve University, 1998. Currently a |
Pulmonary critical care specialist. Co-authorship (publication number 4 & 15). Practicing pulmonologist in Cleveland, OH |
Esam Elashi Renal Fellow research rotation, Case Western Reserve University, 1999- |
2000. Practicing nephrologist. Co-authorship (publication number 4 & 15). Practicing nephrologist in Sandusky, Ohio |
Srinivasan Dasarathy Junior faculty member at CWRU 2003-2006, now funded faculty at Cleveland Clinic Lerner Research Center. |
Imran Chaudhry Research mentoring resulting in a publication. MetroHealth Center |
2005-2006. Authored a manuscript number 13. |
Angali Chiothani Summer student, Medical College of Wisconsin 2008 - Admitted to Medical School. |
Kate Niemer Summer student, Medical College of Wisconsin. 2009. |
Victoriya Rufanova Research Associate. Medical College of Wisconsin 2008-2010. Secured a SBIR grant. |
Sujeet Kumar, MD Renal Fellow. Medical College of Wisconsin 2009. Clinical mentoring |
Resulted in publication number 12. |
Adil Jadoon Research mentorship 2011-2012. Medical College of Wisconsin. Abstract number 16. Currently, on the faculty on the nephrology division, University of Michigan. |
Sterling Udom Medical Student, research pathway. 2014-2015. Abstract number 16. |
Kayla Schwartz Summer student, Medical College of Wisconsin 2017 |
Liliana Osadchuk Assistant Professor of Medicine. 2014-2019. Abstract number 18 |
2015, 2016, 2017, 2018, 2019 |
BIBLIOGRAPHY |
Abstracts |
1. M.A. El-Meanawy, N.B. Philips, R.E. Davis, and A.H. Davis. (1989) Schistosoma mansoni hemoglobinase is processed from a 50 Kd form to the mature 31 Kd enzyme Clin. Res. 37, 2: 435A. |
2. R.E. Kalayjian, M.A. El-Meanawy, and A.H. Davis. (1989) Differential gene expression in Schistosoma mansoni: hemoglobinase. Clin. Res. 37, 2: 435A. |
3. M.A. El-Meanawy, R.E. Davis, A. Rajkovic, and F.M.. Rottman. (1993) Characterization of snRNAs from Schistosoma mansoni. Cellular Biochemistry 17C supp.: 100. |
4. El-Meanawy, J. Schelling, E. Elashi, S. Barathan, M. Konieczkowski, S. Kamat, A. Koepke, K. Goddard, A. Covic, S. Iyengar, J. Sedor: (2000) Comparison of mRNA Kidney Expression Profiles Generated by Serial Analysis of Gene Expression (SAGE) To Identify Candidate Nephropathy Genes in C57BL/6-Os/+ Versus ROP-Os/+ Mice. ASN annual meeting; A3253. |
5. M. Ashraf El-Meanawy, Shrinath Barathan, Tatjana Dodig, Essam Elashi, Katrina Goddard, Sudha K. Iyengar, Jeffrey R. Schelling and John R. Sedor. (2001) Kidney Transcriptome Profiles Generated by Serial Analysis of Gene Expression (SAGE) Identify Candidate Molecular Pathways Regulating Progressive Glomerulosclerosis. (ASN/ISN world congress of nephrology). |
6. El-Meanawy, A. Barathan, M. Konieczkowski, E. Elashi, A. Covic, T. Dodig, S. Khan, A. Koepke, F. Pozuelo, K. Godard, S. Iyengar, J.R. Schelling and J.R. Sedor (2001) Gene expression profiles generated by serial analysis of gene expression (SAGE) identify candidate molecular pathways regulating progressive glomerulosclerosis. (ERAEDTA). |
7. Shrinath Barathan, Martha Konieczkowski, Ashraf El-Meanawy, Shenaz Khan, Bingcheng Wang, Tatjana Dodig, Sudha K. Iyengar, Jeffrey R. Schelling and John R. Sedor (2001). Expression Analysis Demonstrates the Cell Guidance Signal Neuropilin 2b (nrp2) Is Reduced in Sclerosis-prone ROP-Os/+ but not Sclerosis-resistant C57-Os/+ Mouse Kidneys. (ASN/ISN world congress of nephrology). |
8. Ashraf El-Meanawy, Tatjana Drahotusky-Dodig, Sudha Iyengar, Jeffrey R. Schelling, John R. Sedor.(2002) Genetic Abnormality of the Oligosyndactyly Mouse Model: Implications of Potential Candidate Genes. ASN annual scientific meeting, SA-P0209. |
9. Ashraf El-Meanawy MD, PhD, Jeffrey R Schelling, MD, Sudha K Iyengar, PhD and John R Sedor, MD. (2003). The Os mouse 50 years later: Is a gain of function mutation the answer? ASN kidney week. |
10. Ashraf El-Meanawy MD*, PhD and Milos Tatalovic, BS (2007). Defective Nephrogenesis in the Oligosyndactyly Mouse; Could Ubiquitination Abnormality Be the Culprit? ASN annual meeting. |
11. Victoriya A. Rufanova, Kate Niemer, Ashraf El-Meanawy (2009). Decrease in SnoN protein level is associated with reduced ureteric tip branching during kidney embryonic development. ASN renal week. |
12. Ashraf El-Meanawy, Victoriya Rufanova, and Cary T Stelloh (2010). Hedgehog Controls Ureteric Bud Branching Morphogenesis and Contribute to Reduced Nephron Number in a Mouse Model of Oligomeganephronia. ASN renal week. |
13. Ashraf El-Meanawy, Kenneth Allen, Victoriya Rufanova, and Cary Stelloh (2011). Prematurity leads to reduced nephron number and hypertension. Combined Annual Meeting of CSCR and MWAFMR. |
14. Ashraf El-Meanawy, Victoriya Rufanova, and Cary Stelloh (2012). Premature delivery triggers termination of nephrogenesis program which leads to reduced nephron number and hypertension. European Renal Association and European Dialysis and Transplantat Association (ERA-EDTA) Congress 2012. |
15. Ashraf El-Meanawy and Vinh Nguyen. ACTH A Novel Treatment for IgA Nephropathy. (2013) ASN kidney week. |
16. Ashraf El-Meanawy, Sterling Udom, and Adil Jadoon. The Super kidney; Putting the Foundation for the Future.(2013) ASN Kidney week. |
17. Anjay Rastogi, Mitchell H. Rosner, Irina Barash, Theodore I. Steinman, Ziad El-Zoghby, Saul Nurko, Seth Goldberg, Ashraf El-Meanawy, Mireille El Ters, Maria Roche,and Mark S Berger. Tyrosine Kinase Inhibitor Tesevatinib for Patients with Autosomal Dominant Polycystic Kidney Disease. (2015) ASN Kidney Week. |
18. Ashraf El-Meanawy and Liliana Osadchuk. Identifying Donors at Risk for Developing Chronic Kidney Disease Using Non-Invasive Ultrasound-Based Measurement of Glomerular Diameter. (2016) ASN kidney week. |
19. Endres BT, Sandoval RM, Staruschenko A, El-Meanawy A, Molitoris BA, Geurts AM, Palygin O. Role of albuminuria in the development of salt-sensitive hypertension. (2016) Telluride Conference on Epithelial Physiology and Cell Biology. |
20. Eiznhamer, David A., Rastogi, Anjay, Chonchol, Michel, El-Meanawy, Ashraf, Steinman, Theodore, Herrera, Karin, Schueller, Olivier, Ryan, John, and Pergola, Pablo. Reversibility of Serum Creatinine Elevation Observed in ADPKD Subjects Receiving the Tyrosine Kinase Inhibitor Tesevatinib. (2017) ASN Kidney Week. |
21. Oleg Palygin, Vladislav Levchenko, Ashraf El-Meanawy, Alexander Staruschenko 2017. Proximal Tubule-mediated Control of Albumin Balance During the Development of Salt-sensitive Hypertension, (2017) AHA annual meeting. |
22. Levchenko V, Palygin O, Bukowy JD, Cowley A, El-Meanawy A, and Staruschenko A. L-lysine Control of Albumin Reabsorption by the Renal Proximal Tubule Prevents the Development of Salt-Sensitive Hypertension. Hypertension. Abstract Number: 134. (2017) American Heart Association's Hypertension 2017 Scientific Sessions. |
23. Khedr S, Palygin O, Pavlov TS, Blass G, Levchenko V, Alsheikh A, Brands MW, El-Meanawy A, Staruschenko A. Increased ENaC Activity During Kidney Preservation in Wisconsin Solution. (2017) Cardiovascular Center Research Retreat. |
24. Palygin O, Levchenko V, El-Meanawy A, Staruschenko A. Proximal Tubule-mediated Control of Albumin Balance During the Development of Salt-sensitive Hypertension. (2018) FASEB. Abstract Number: 716.5. Experimental Biology. |
25. Vladislav Levchenko, Oleg Palygin, John D Bukowy, Allen W. Cowley Jr., Ashraf El-Meanawy, and Alexander Staruschenko. L-lysine Control of Albumin Reabsorption by the Renal Proximal Tubule Prevents the Development of Salt-Sensitive Hypertension (2018). Experimental Biology. |
26. Kayla Schwartz and Ashraf El-Meanawy. Efficient Clearance of Free Light Chains Using Hemofiltration. (2018) CSCTR-MWAFMR combined meeting. |
27. Spires D, Ilatovskaya DV, Levchenko V, Bohovyk R, Fedoriuk M, Sykes O, Bukowy J, El-Meanawy A, Staruschenko A, Oleg Palygin O. Sex Differences in the Progression of Type 2 Diabetic Nephropathy. (2019) 14th Annual Chicago Diabetes Day. |
28. Golosova D, Palygin O, Levchenko V, El-Meanawy A, Staruschenko A. The effect of κ-opioid receptors stimulation on podocyte injury and kidney function. (2019) Vasculata. |
29. Palygin O, Isaeva A, Shalygin A, Bohovyk R, Fedoriuk M, Klemens C, El-Meanawy A, Denton J, Staruschenko A. Modulation of ENaC mediated sodium transport by the basolateral Kir4.1/Kir5.1 channels. Aldosterone and ENaC in Health and Disease: (2019) The Kidney and Beyond Conference. |
30. David A. Eiznhamer, Pablo E. Pergola, Michel Chonchol, Ashraf El-Meanawy, Theodore I. Steinman, Karin Herrera, Nicole Martins, Swati Bhattacharya, Olivier Schueller, John L. Ryan, and Anjay Rastogi. Safety and efficacy results from the SILK (Safety in Larger Kidneys) cohort of KD019-101 a phase 1b/2a trial of the tyrosine kinase inhibitor tesevatinib for patients with ADPKD. (2019) submitted for ASN Kidney Week. |