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CURRICULUM VITAE

Ashraf El-Meanawy MD, PhD
Professor
Department of Medicine
Division of Nephrology

OFFICE ADDRESS:
Health Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226

EDUCATION:
07/1987 - 10/1990 MD & PhD Medicine/Surgery Biochemistry & Molecular Biology, Cairo University, Cairo, Egypt

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
04/1991 - 12/1993 Post Doctoral Fellow, Molecular and Microbiology, Case Western Reserve University, Cleveland, OH
01/1994 - 12/1996 Resident, Internal Medicine, Case Western Reserve University, Cleveland, OH
01/1997 - 06/1999 Clinical Instructor (NIH Grant, Nephrology Research), Case Western Reserve University, Cleveland, OH
07/2003 - 09/2006 Nephrology Fellow, Nephrology, Case Western Reserve University, Cleveland, OH

FACULTY APPOINTMENTS:
07/1999 - 08/2007 Assistant Professor of Medicine, Case Western Reserve University, OH, Nephrology Division, Cleveland
09/2007 - 06/2013 Assistant Professor of Medicine, Medical College of Wisconsin, WI, Nephrology Division, Milwaukee
02/2013 - Present Associate Professor of Medicine, Medical College of Wisconsin, WI, Nephrology Division, Milwaukee
07/01/2019 - Present Professor of Medicine, Medicine, Nephrology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226

ADMINISTRATIVE APPOINTMENTS:
09/2007 - Present Froedtert Memorial Lutheran Hospital, Milwaukee, Wisconsin
07/2009 - Present Zablocki VA Medical Center, Milwaukee, Wisconsin
03/2013 - Present Community Memorial Hospital, Menomonie Falls, Wisconsin
06/2014 - Present Director of outpatient Dialysis, Medical College of Wisconsin
06/2014 - Present Medical Director, FMC center point dialysis center
06/2014 - Present Medical Director, Home dialysis program, FMC
06/2014 - Present Director of inpatient dialysis, MCW associated hospitals
06/2018 - Present Medical Director, FMC Brookfield, dialysis center
CURRENT HOSPITAL STAFF PRIVILEGES:

AWARDS AND HONORS:
1990 - Present Young Scientist Award, Schistosomiasis Research Project (US-AID)
1993 - Present Resident research award, Case Western Reserve / MetroHealth
1995 - 1996 Pharmacy and Therapeutic Committee, MetroHealth Medical Center
1998 - Present American Society of Nephrology
2001 - 2007 PDA Advisory Committee, MetroHealth Medical Center
2001 - 2007 Information Services Advisory Committee, MetroHealth Medical Center, Rammelkamp Center for Research
2011 - 2014 European Renal Association/EDTA
2011 - 2014 IRB, Medical College of Wisconsin
2012 - Present American Physiologic Society
2013 - Present Featured New Investigator Award, Central Society of Clinical Research, CSCR
2013 - Present Research and Development Committee, Milwaukee VA Medical Center.
2013 - 2015 Medicine IT committee, Medical College of Wisconsin
2014 - Present Presnet System inpatient platform committee, Froedtert Health, Milwaukee, WI.
2014 - 2017 Diversity and Inclusion Advisory Committee (DIAC), MCW
2014 - Present Director of outpatient dialysis, Medical College of Wisconsin.
2014 - Present Director of inpatient dialysis, Medical College of Wisconsin Associated Hospitals.
2014 - 2017 Research Committee, Medical College of Wisconsin.
2015 - 2018 Faculty Council elected member, Medical College of Wisconsin.
2015 - Present Board of director, National Kidney Foundation, Wisconsin chapter.
2017 - Present Platinum Most valuable member, ASN communities
2018 - Present Fellow of the American Society of Nephrology
2019 - Present Named Nephrotic Syndrome Expert, by NephCure Kidney International
PROFESSIONAL MEMBERSHIPS
LOCAL/REGIONAL LEADERSHIP AND COMMITTEE POSITIONS:

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorial Board
2014 - Present Presnet PLOS1
2015 - Present Journal of Clinical Investigation-Insight
2016 - Present International Journal of Nephrology
2018 - Present Frontiers in Physiology
2018 - Present Clinical Transplantation
2018 - Present American Journal of Renal Physiology
Journal Reviewer

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
"Targeting PGE2 Receptors to attenuate shear stress-induced glomerular injury"
Source:
NIH NIDDK R01DK107490
Role & Effort:
Co-Investigator (PI Tarak Srivastava)
Dates:
08/27/2016 - 04/30/2021
  
Title:
"Role of p66Shc in Regulation of Microvascular Reactivity of Renal Blood Vessels"
Source:
NIH/NHLBI R01-1R01HL147976-01
Role & Effort:
Co-Investigator (PI Andrey Sorokin)
Dates:
07/01/2019 - 06/30/2024
  
Non-Peer Review
Title:
"Morphometric Evaluation of Kidneys in Premature Born Subjects" (glomerular diameter evaluation using non-invasive ultrasound in relation to renal function)
Source:
Siemens
Role & Effort:
PI - Study design, execution, and data analysis
Dates:
12/1201 - Present
  
Title:
"Glomerular Diameter and Renal Function"
Source:
Froedtert Foundation
Role & Effort:
PI - Study design, execution, and data analysis
Dates:
2014 - Present
  
Title:
Multicenter, randomized, double-blind, placebo-controlled two stage study to characterize the efficacy, safety, tolerability and pharmacokinetics of GZ/SAR402671 in patients at risk of rapidly progressive ADPKD"
Source:
Sanofi
Role & Effort:
PI - study execution
Dates:
- 2019
  
Title:
"Lysine and albuminuria"
Source:
Variable account funds
Role & Effort:
PI - study design execution
Dates:
- 2017
  
Title:
"A Phase 2 Study to Evaluate the Safety and Effect on Proteinuria of
Source:
Omeros Corp.
Role & Effort:
Site PI - study execution
Dates:
- 2016
  
Title:
"A Phase 3, Open-Label, Randomized, Active-Controlled Study of the Efficacy and Safety of Roxadustat (FG-4592) in the Maintenance Treatment of Anemia in End Stage Renal Disease (ESRD) Subjects on Stable Dialysis Patients"
Source:
Fibrogen
Role & Effort:
Site PI- study execution
Dates:
- 2015
  
Title:
"A Phase 3, Multicenter, Randomized, Open-Label, Active-Controlled Study of the Efficacy and Safety of FG-4592 in the Treatment of Anemia in Incident-dialysis Patients"
Source:
Fibrogen
Role & Effort:
Site PI- study execution
Dates:
- 2015
  
Title:
"A Phase 1b/2a, Safety, Pharmacokinetic and Dose-Escalation Study of KD019 in Subjects with Autosomal Dominant Polycystic Kidney Disease."
Source:
Kadmon Corp.
Role & Effort:
Site PI - study execution
Dates:
- 2014
  
Title:
"A Double-blind Randomized Parallel Group Study of the Efficacy and Safety of Tesevatinib in subjects with Autosomal Dominant Polycystic Kidney Disease"
Source:
Kadmon Corp.
Role & Effort:
Site PI - study execution
Dates:
- 2017
  
Prior
Peer Review
Title:
"Quantitative Expression Libraries to Identify ESRD Genes"
Source:
NIH NIDDK 5K08DK002699
Role & Effort:
Principal Investigator
Dates:
2000 - 2005
  
Title:
P&F Project "Nephron number regulation"
Source:
Sub-grant from "Integrative Biology of Childhood Kidney Disease, NIH NIDDK 5P50DK079306
Role & Effort:
Principal Investigator
Dates:
2009 - 2011
  
Non-Peer Review
Title:
"Early Kidney development"
Source:
Lemann Endowment, MCW.
Role & Effort:
Principal Investigator
Dates:
2011 - 2013
  
Title:
"Study of Potential Nephrotoxicity of Gadolinium-based Magnetic Resonance Contrast Media"
Role & Effort:
Principal Investigator- study design and execution
Dates:
- 2014
  
Title:
Title "Cardiotrophin-like Cytokine-1 (CLC-1) in Humans "
Role & Effort:
Principal Investigator - study design and execution
Dates:
- 2014
  
  

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
International
- Leuven University, Belgium, 05/2012 - Present
 
National
- Kidney Institute, Kansas University, 04/2010 - Present
- Baylor school of Medicine, Houston, - 09/2018
- Keck school of Medicine, University of southern CA 11/2018: Title: "A new era for ultrasound, Identifying nephron deficiency and risk for kidney disease progression"
- Keynote speaker, Versiti retreat, Zion, - 05/2018
- University of Wisconsin, Madison, WI 3/2016: Title: "Nephron Number, Kidney Disease, Hypertension, and Tales from the Womb"
- NephCure, Chicago, IL 4/2015: Title "FSGS Disease Overview and Nephrotic Syndrome Considerations, Presentation, and Prognosis"
- CSCTR/MMAFR meeting invited speaker. Chicago, IL 4/2013. Title "Nephron Adequacy, Prematurity, and Tales from the Womb".
- Loma Linda University and Loma Linda VA Medical Center, 11/2011. Title "The Fateful Trihedron; Nephron Adequacy, Hypertension and Kidney Disease"
 
Local
-Medicine Grand Rounds, Froedtert and the Medical College of Wisconsin, 01/2008 - Present
-Medicine Grand Rounds: Froedtert and the Medical College of Wisconsin, 01/2013 - Present
- Concordia University, WI, 10/2015 - Present
-Medicine Grand Rounds: Froedtert and the Medical College of Wisconsin, 05/2011. Title "Nephron Number, Hypertension and Kidney Disease: Late Manifestation of an Early Problem"
-Medicine Grand Rounds, Clement J Zablocki VA Medical Center, 05/2010. Title "Vitamin D; For Calcium, Bone, and Beyond"
-Medicine Grand Rounds, Clement J Zablocki VA Medical Center, Milwaukee, WI 02/2014. Title "Amyloidosis, Not So Uncommon"
- Children Research Institute, Milwaukee, WI 9/2015: Title "Prematurity, Perinatal Environment, Nephron number and adult kidney Disease".
TEACHING ACTIVITIES:
Harvard School of Tropical Medicine and Hygiene:
1992
Course title: "Biology of Parasitism"
Case Western Reserve University:
2005-2006
Course title: "First-year renal physiology course"
Small group conferences teaching GFR and Tubular Function, Na+, K+, and Water Handling, Volume Homeostasis, Acid-Base, and Fluid and Electrolyte Balance
Medical College of Wisconsin:
2008
Course title: "Clinical Examination and Reasoning"
2014
Course title: Discovery Curriculum; "Chronic Kidney Disease"
and manuscript in preparation number 27.
Course title Renal Physiology for graduate students
COMMUNITY AND VOLUNTEER SERVICE:
2008 - 2011 Volunteer Soccer coach for Brookfield Soccer Association
2009 - CKD Screening, National Kidney Foundation.
2012 - Saturday Clinic for the Un-insured (Milwaukee WI)
2010 - 2011 Patient educational seminars, Polycystic Kidney Disease (PKD) Foundation
MENTEES:
Current:
Daniel Fahernbach Graduate student, physiology. 2018-current. PhD Committee Member.
Andrew Maike Nephrology fellow. 2019-current. Fellow research project
Previous:
Aoron Sop Chester scholar student at MetroHealth Center, Case Western Reserve
University. 1997. Orthopedic surgeon.
Fatima Pozuelo Research rotation, Case Western Reserve University, 1998. Currently a
Pulmonary critical care specialist. Co-authorship (publication number 4 & 15). Practicing pulmonologist in Cleveland, OH
Esam Elashi Renal Fellow research rotation, Case Western Reserve University, 1999-
2000. Practicing nephrologist. Co-authorship (publication number 4 & 15). Practicing nephrologist in Sandusky, Ohio
Srinivasan Dasarathy Junior faculty member at CWRU 2003-2006, now funded faculty at Cleveland Clinic Lerner Research Center.
Imran Chaudhry Research mentoring resulting in a publication. MetroHealth Center
2005-2006. Authored a manuscript number 13.
Angali Chiothani Summer student, Medical College of Wisconsin 2008 - Admitted to Medical School.
Kate Niemer Summer student, Medical College of Wisconsin. 2009.
Victoriya Rufanova Research Associate. Medical College of Wisconsin 2008-2010. Secured a SBIR grant.
Sujeet Kumar, MD Renal Fellow. Medical College of Wisconsin 2009. Clinical mentoring
Resulted in publication number 12.
Adil Jadoon Research mentorship 2011-2012. Medical College of Wisconsin. Abstract number 16. Currently, on the faculty on the nephrology division, University of Michigan.
Sterling Udom Medical Student, research pathway. 2014-2015. Abstract number 16.
Kayla Schwartz Summer student, Medical College of Wisconsin 2017
Liliana Osadchuk Assistant Professor of Medicine. 2014-2019. Abstract number 18
2015, 2016, 2017, 2018, 2019
 


BIBLIOGRAPHY
Abstracts
1. M.A. El-Meanawy, N.B. Philips, R.E. Davis, and A.H. Davis. (1989) Schistosoma mansoni hemoglobinase is processed from a 50 Kd form to the mature 31 Kd enzyme Clin. Res. 37, 2: 435A.
2. R.E. Kalayjian, M.A. El-Meanawy, and A.H. Davis. (1989) Differential gene expression in Schistosoma mansoni: hemoglobinase. Clin. Res. 37, 2: 435A.
3. M.A. El-Meanawy, R.E. Davis, A. Rajkovic, and F.M.. Rottman. (1993) Characterization of snRNAs from Schistosoma mansoni. Cellular Biochemistry 17C supp.: 100.
4. El-Meanawy, J. Schelling, E. Elashi, S. Barathan, M. Konieczkowski, S. Kamat, A. Koepke, K. Goddard, A. Covic, S. Iyengar, J. Sedor: (2000) Comparison of mRNA Kidney Expression Profiles Generated by Serial Analysis of Gene Expression (SAGE) To Identify Candidate Nephropathy Genes in C57BL/6-Os/+ Versus ROP-Os/+ Mice. ASN annual meeting; A3253.
5. M. Ashraf El-Meanawy, Shrinath Barathan, Tatjana Dodig, Essam Elashi, Katrina Goddard, Sudha K. Iyengar, Jeffrey R. Schelling and John R. Sedor. (2001) Kidney Transcriptome Profiles Generated by Serial Analysis of Gene Expression (SAGE) Identify Candidate Molecular Pathways Regulating Progressive Glomerulosclerosis. (ASN/ISN world congress of nephrology).
6. El-Meanawy, A. Barathan, M. Konieczkowski, E. Elashi, A. Covic, T. Dodig, S. Khan, A. Koepke, F. Pozuelo, K. Godard, S. Iyengar, J.R. Schelling and J.R. Sedor (2001) Gene expression profiles generated by serial analysis of gene expression (SAGE) identify candidate molecular pathways regulating progressive glomerulosclerosis. (ERAEDTA).
7. Shrinath Barathan, Martha Konieczkowski, Ashraf El-Meanawy, Shenaz Khan, Bingcheng Wang, Tatjana Dodig, Sudha K. Iyengar, Jeffrey R. Schelling and John R. Sedor (2001). Expression Analysis Demonstrates the Cell Guidance Signal Neuropilin 2b (nrp2) Is Reduced in Sclerosis-prone ROP-Os/+ but not Sclerosis-resistant C57-Os/+ Mouse Kidneys. (ASN/ISN world congress of nephrology).
8. Ashraf El-Meanawy, Tatjana Drahotusky-Dodig, Sudha Iyengar, Jeffrey R. Schelling, John R. Sedor.(2002) Genetic Abnormality of the Oligosyndactyly Mouse Model: Implications of Potential Candidate Genes. ASN annual scientific meeting, SA-P0209.
9. Ashraf El-Meanawy MD, PhD, Jeffrey R Schelling, MD, Sudha K Iyengar, PhD and John R Sedor, MD. (2003). The Os mouse 50 years later: Is a gain of function mutation the answer? ASN kidney week.
10. Ashraf El-Meanawy MD*, PhD and Milos Tatalovic, BS (2007). Defective Nephrogenesis in the Oligosyndactyly Mouse; Could Ubiquitination Abnormality Be the Culprit? ASN annual meeting.
11. Victoriya A. Rufanova, Kate Niemer, Ashraf El-Meanawy (2009). Decrease in SnoN protein level is associated with reduced ureteric tip branching during kidney embryonic development. ASN renal week.
12. Ashraf El-Meanawy, Victoriya Rufanova, and Cary T Stelloh (2010). Hedgehog Controls Ureteric Bud Branching Morphogenesis and Contribute to Reduced Nephron Number in a Mouse Model of Oligomeganephronia. ASN renal week.
13. Ashraf El-Meanawy, Kenneth Allen, Victoriya Rufanova, and Cary Stelloh (2011). Prematurity leads to reduced nephron number and hypertension. Combined Annual Meeting of CSCR and MWAFMR.
14. Ashraf El-Meanawy, Victoriya Rufanova, and Cary Stelloh (2012). Premature delivery triggers termination of nephrogenesis program which leads to reduced nephron number and hypertension. European Renal Association and European Dialysis and Transplantat Association (ERA-EDTA) Congress 2012.
15. Ashraf El-Meanawy and Vinh Nguyen. ACTH A Novel Treatment for IgA Nephropathy. (2013) ASN kidney week.
16. Ashraf El-Meanawy, Sterling Udom, and Adil Jadoon. The Super kidney; Putting the Foundation for the Future.(2013) ASN Kidney week.
17. Anjay Rastogi, Mitchell H. Rosner, Irina Barash, Theodore I. Steinman, Ziad El-Zoghby, Saul Nurko, Seth Goldberg, Ashraf El-Meanawy, Mireille El Ters, Maria Roche,and Mark S Berger. Tyrosine Kinase Inhibitor Tesevatinib for Patients with Autosomal Dominant Polycystic Kidney Disease. (2015) ASN Kidney Week.
18. Ashraf El-Meanawy and Liliana Osadchuk. Identifying Donors at Risk for Developing Chronic Kidney Disease Using Non-Invasive Ultrasound-Based Measurement of Glomerular Diameter. (2016) ASN kidney week.
19. Endres BT, Sandoval RM, Staruschenko A, El-Meanawy A, Molitoris BA, Geurts AM, Palygin O. Role of albuminuria in the development of salt-sensitive hypertension. (2016) Telluride Conference on Epithelial Physiology and Cell Biology.
20. Eiznhamer, David A., Rastogi, Anjay, Chonchol, Michel, El-Meanawy, Ashraf, Steinman, Theodore, Herrera, Karin, Schueller, Olivier, Ryan, John, and Pergola, Pablo. Reversibility of Serum Creatinine Elevation Observed in ADPKD Subjects Receiving the Tyrosine Kinase Inhibitor Tesevatinib. (2017) ASN Kidney Week.
21. Oleg Palygin, Vladislav Levchenko, Ashraf El-Meanawy, Alexander Staruschenko 2017. Proximal Tubule-mediated Control of Albumin Balance During the Development of Salt-sensitive Hypertension, (2017) AHA annual meeting.
22. Levchenko V, Palygin O, Bukowy JD, Cowley A, El-Meanawy A, and Staruschenko A. L-lysine Control of Albumin Reabsorption by the Renal Proximal Tubule Prevents the Development of Salt-Sensitive Hypertension. Hypertension. Abstract Number: 134. (2017) American Heart Association's Hypertension 2017 Scientific Sessions.
23. Khedr S, Palygin O, Pavlov TS, Blass G, Levchenko V, Alsheikh A, Brands MW, El-Meanawy A, Staruschenko A. Increased ENaC Activity During Kidney Preservation in Wisconsin Solution. (2017) Cardiovascular Center Research Retreat.
24. Palygin O, Levchenko V, El-Meanawy A, Staruschenko A. Proximal Tubule-mediated Control of Albumin Balance During the Development of Salt-sensitive Hypertension. (2018) FASEB. Abstract Number: 716.5. Experimental Biology.
25. Vladislav Levchenko, Oleg Palygin, John D Bukowy, Allen W. Cowley Jr., Ashraf El-Meanawy, and Alexander Staruschenko. L-lysine Control of Albumin Reabsorption by the Renal Proximal Tubule Prevents the Development of Salt-Sensitive Hypertension (2018). Experimental Biology.
26. Kayla Schwartz and Ashraf El-Meanawy. Efficient Clearance of Free Light Chains Using Hemofiltration. (2018) CSCTR-MWAFMR combined meeting.
27. Spires D, Ilatovskaya DV, Levchenko V, Bohovyk R, Fedoriuk M, Sykes O, Bukowy J, El-Meanawy A, Staruschenko A, Oleg Palygin O. Sex Differences in the Progression of Type 2 Diabetic Nephropathy. (2019) 14th Annual Chicago Diabetes Day.
28. Golosova D, Palygin O, Levchenko V, El-Meanawy A, Staruschenko A. The effect of κ-opioid receptors stimulation on podocyte injury and kidney function. (2019) Vasculata.
29. Palygin O, Isaeva A, Shalygin A, Bohovyk R, Fedoriuk M, Klemens C, El-Meanawy A, Denton J, Staruschenko A. Modulation of ENaC mediated sodium transport by the basolateral Kir4.1/Kir5.1 channels. Aldosterone and ENaC in Health and Disease: (2019) The Kidney and Beyond Conference.
30. David A. Eiznhamer, Pablo E. Pergola, Michel Chonchol, Ashraf El-Meanawy, Theodore I. Steinman, Karin Herrera, Nicole Martins, Swati Bhattacharya, Olivier Schueller, John L. Ryan, and Anjay Rastogi. Safety and efficacy results from the SILK (Safety in Larger Kidneys) cohort of KD019-101 a phase 1b/2a trial of the tyrosine kinase inhibitor tesevatinib for patients with ADPKD. (2019) submitted for ASN Kidney Week.