Faculty Collaboration Database

1. KALYANARAMAN, B., Atwood, J. L., and Kispert, L. D. Role of intermolecular hydrogen-bonding in the crystal structure of alpha-chloroacetic acid. J. Chem. Soc. Chem. Comm. 715-16, 1976.

2. KALYANARAMAN, B., Kispert, L. D., and Atwood, J. L. The disordered crystal structure of chlorodifluoroacetamide. J. Cryst. Mol. Struct. 6:311-6, 1976.

3. KALYANARAMAN, B., Kispert, L. D., and Atwood, J. L. The disordered crystal structure of bromodifluoroacetamide and trifluoroacetamide. Acta Cryst. B34:1131-6, 1978.

4. KALYANARAMAN, B., Kispert, L. D., and Atwood, J. L. Crystal structure of 2-chloroacetamide (alpha-form): a reinvestigation. J. Cryst. Mol. Struct. 8:175, 1978.

5. KALYANARAMAN, B. and Kispert, L. D. The ESR study of CF3--F radical in irradiated trifluoroacetamide single crystals. J. Chem. Phys. 68:5219-24, 1978.

6. KALYANARAMAN, B. and Kispert, L. D. The ESR and INDO study of an oxygen centered radical in irradiated 2-chloroacetamide. J. Chem. Phys. 68:5331-5, 1978.

7. KALYANARAMAN, B., Perez-Reyes, E., Mason, R. P., Peterson, F. J., and Holtzman, J. L. Electron spin resonance evidence for a free radical intermediate in the cis-trans isomerizetion of furylfuramide by oxygen-sensitive nitroreductases. Mol. Pharmacol. 16:1059-64, 1979.

8. KALYANARAMAN, B., Perez-Reyes, E., and Mason, R. P. The reduction of nitroso-spin traps in chemical and biological systems. A cautionary note. Tetrahedron Lett. 5:4809-12, 1979.

9. KALYANARAMAN, B., Mason, R. P., Perez-Reyes, E., Chignell, C. F., Wolf, C. R., and Philpot, R. M. Characterization of the free radical formed in aerobic microsomal incubations containing carbon tetrachloride and NADPH. Biochem. Biophys. Res. Commun. 89:1065-72, 1979.

10. Perez-Reyes, E., KALYANARAMAN, B., and Mason, R. P. The reductive metabolism of metronidazole and ronidazole by aerobic liver microsomes. Mol. Pharmacol. 17:239-44, 1980.

11. KALYANARAMAN, B., Perez-Reyes, E., and Mason, R. P. Spin-trapping and direct electron spin resonance investigations of the redox metabolism of quinone anticancer drugs. Biochim. Biophys. Acta 630:119-30, 1980.

12. Mason, R. P., KALYANARAMAN, B., Tainer, B., and Eling, T. E. A carbon-centered free radical intermediate in the prostaglandin synthetase oxidation of arachidonic acid. Spin trapping and oxygen uptake studies. J. Biol. Chem. 255:5019-22, 1980.

13. Wolf, C. R., Harrelson, W. G. Jr., Nastainczyk, W. M., Philpot, R. M., KALYANARAMAN, B., and Mason, R. P. Metabolism of carbon tetrachloride in hepatic microsomes and reconstituted monooxygenase systems and its relationship to lipid peroxidation. Mol. Pharmacol. 18:553-8, 1980.

14. Chignell, C. F., KALYANARAMAN, B., Mason, R. P., and Sik, R. H. Spectroscopic studies of cutaneous photosensitizing agents. I. Spin trapping of photolysis products from sulfanilamide, 4-aminobenzoic acid and related compounds. Photochem. Photobiol. 32:563, 1980.

15. Chignell, C. F., KALYANARAMAN, B., Sik, R. H., and Mason, R. P. Spectroscopic studies of cutaneous photosensitizing agents. II. Spin trapping of photolysis products from sulfanilamide and 4-aminobenzoic acid using 5,5-dimethyl-1-pyrroline-1-oxide (DMPO). Photochem. Photobiol. 34:147, 1981.

16. Roger, R. D., KALYANARAMAN, B., Dalton, S. M., Smith, W., Kispert, L. D., and Atwood, J. L. Crystal structure of bromofluoroacetic acid: a chiral molecule. J. Cryst. Mol. Struct. 11:104, 1981.

17. Lasker, J. M., Sivarajah, K., Mason, R. P., KALYANARAMAN, B., Abou-Donia, M. B., and Eling, T.E. A free radical mechanism of prostaglandin synthetase-dependent aminopyrine demethylation. J. Biol. Chem. 256, 7764-7, 1981.

18. KALYANARAMAN, B., Mason, R. P., Rowlett, R., and Kispert, L. D. An electron spin resonance investigation and molecular orbital calculation of the anion radical intermediate in the enzymatic cis-trans isomerization of furylfuramide, a nitrofuran derivative of ethylene. Biochim. Biophys. Acta 660:102-9, 1981.

19. Mottley, C., KALYANARAMAN, B., and Mason, R. P. Spin trapping artifacts due to the reduction of nitroso spin traps. FEBS Lett. 130:12, 1981.

20. KALYANARAMAN, B., Mason, R. P., Tainer, B., and Eling, T. E. The free radical formed during the hydroperoxide-mediated deactivation of ram seminal vesicles is hemoprotein-derived. J. Biol. Chem. 257:4764-8, 1982.

21. KALYANARAMAN, B., Mason, R. P., and Sivarajah, K. An electron spin resonance study of the novel radical cation produced during the horseradish peroxidase-catalyzed oxidation of tetramethylhydrazine. Biochem. Biophys. Res. Commun. 105:217-24, 1982.

22. KALYANARAMAN, B. and Sealy, R. C. Electron spin resonance--spin stabilization in enzymatic systems: detection of semiquinones produced during peroxidatic oxidation of catechols and catecholamines. Biochem. Biophys. Res. Commun. 106:1119-25, 1982.

23. KALYANARAMAN, B., Felix, C. C., and Sealy, R. C. Photoionization of melanin precursors: An electron spin resonance investigation using the spin trap 5,5-dimethyl-1-pyrroline-1-oxide (DMPO). Photochem. Photobiol. 36:5, 1982.

24. KALYANARAMAN, B., Sivarajah, K., Eling, T. E., and Mason, R. P. A free radical mediated cooxidation of tetramethylhydrazine by prostaglandin hydroperoxidase. Carcinogenesis 4:1341-3, 1983.

25. KALYANARAMAN, B., Mottley, C., and Mason, R. P. A direct electron spin resonance and spin-trapping investigation of peroxyl free radical formation by hematin/hydroperoxide systems. J. Biol. Chem. 258:3855-8, 1983.

26. Sinha, B. K., Trush, M. A., and KALYANARAMAN, B. Free radical metabolism of VP-16 and inhibition of anthracycline-induced lipid peroxidation. Biochem. Pharmacol. 32:3495-8, 1983.

27. Samskog, P. O., Kispert, L. D., and KALYANARAMAN, B. The structure of the radical anion in an irradiated iodoacetamide: an EPR and INDO study. J.C.S. Faraday Trans. 2 80:267, 1984.

28. KALYANARAMAN, B., Mottley, C., and Mason, R. P. On the use of organic extrac-tion in the spin-trapping technique as applied to biological systems. J. Biochem. Biophys. Methods 9:27-31, 1984.

29. KALYANARAMAN, B., Felix, C. C., and Sealy, R. C. Electron spin resonance-spin stabilization of semiquinones produced during oxidation of epinephrine and its analogues. J. Biol. Chem. 259:354-8, 1984.

30. KALYANARAMAN, B., Sealy, R. C., and Sinha, B. K. An electron spin resonance study of the reduction of peroxides by anthracycline semiquinones. Biochim. Biophys. Acta 799:270-5, 1984.

31. KALYANARAMAN, B., Felix, C. C., and Sealy, R. C. Peroxidatic oxidation of catecholamines. A kinetic electron spin resonance investigation using the spin stabilization approach. J. Biol. Chem. 259:7584-9, 1984.

32. Basosi, R., Sealy, R. C., KALYANARAMAN, B., and Hyde, J. S. Interaction of semiquinones with paramagnetic metal ions in aqueous solution: relaxation and complex formation. J. Magn. Reson. 59:41, 1984.

33. Sealy, R. C., Puzyna, W., KALYANARAMAN, B., and Felix, C. C. Identification by electron spin resonance spectroscopy of free radicals produced during autoxidative melanogenesis. Biochim. Biophys. Acta 800:269-76, 1984.

34. KALYANARAMAN, B., Sealy, R. C., and Sivarajah, K. An electron spin resonance study of o-semiquinones formed during the enzymatic and autoxidation of catechol estrogens. J. Biol. Chem. 259:14018-22, 1984.

35. KALYANARAMAN, B., Felix, C. C., and Sealy, R. C. Photoionization and photohomo¬lysis of eumelanins: an electron spin resonance - spin trapping study. J. Am. Chem. Soc. 106:7327, 1984.

36. Antholine, W. E., Sarna, T., Sealy, R. C., KALYANARAMAN, B., Shields, G. D., and Petering, D. H. Free radicals from the photodecomposition of bleomycin. Photochem. Photobiol. 41, 393-9, 1985.

37. KALYANARAMAN, B. and Sohnle, P. G. Generation of free radical intermediates from foreign compounds by neutrophil-derived oxidants. J. Clin. Invest. 75:1618-22, 1985.

38. Prabhananda, B. S., KALYANARAMAN, B., and Sealy, R. C. Radical anions from one-electron-reduced adrenochrome. Detection and identification by electron spin resonance spectroscopy. Biochim. Biophys. Acta 840:21-8, 1985.

39. KALYANARAMAN, B., Janzen, E. G., and Mason, R. P. Spin trapping of the azidyl radical in azide/catalase/H2O2 and various azide/peroxidase/H2O2 peroxidizing systems. J. Biol. Chem. 260, 4003-6, 1985.

40. Sinha, B. K., Trush, M. A., and KALYANARAMAN, B. Microsomal interactions and inhibition of lipid peroxidation by etoposide (VP-16, 213): implications for mode of action. Biochem. Pharmacol. 34:2036-40, 1985.

41. Sinha, B. K., Strong, J., Gibson, N. W., and KALYANARAMAN, B. Mechanism of DNA strand breaks by mitonafide, an imide derivative of 3-nitro-1,8-naphthalic acid. Biochem. Pharmacol. 34:3845-52, 1985.

42. Korytowski, W., Hintz, P., Sealy, R. C., and KALYANARAMAN, B. Mechanism of dismutation of superoxide produced during autoxidation of melanin pigments. Biochem. Biophys. Res. Commun. 131:659-65, 1985.

43. Kersten, P. J., Tien, M., KALYANARAMAN, B., and Kirk, T. K. The ligninase of Phanero¬chaete chrysosporium generates cation radicals from methoxybenzenes. J. Biol. Chem. 260:2609-12, 1985.

44. Hammel, K. E., Tien, M., KALYANARAMAN, B., and Kirk, T. K. Mechanism of oxidative C alpha-C beta cleavage of a lignin model dimer by Phanerochaete chrysosporium ligninase. Stoichiometry and involvement of free radicals. J. Biol. Chem. 260:8348-53, 1985.

45. Kirk, T. K., Tien, M., Kersten, P. J., Mozuch, M. D., and KALYANARAMAN, B. Ligninase of Phanerochaete chrysosporium. Mechanism of its degradation of the non-phenolic arylglycerol-beta-aryl ether substructure of lignin. Biochem. J. 236:279-87, 1986.

46. Hammel, K. E., KALYANARAMAN, B., and Kirk, T. K. Substrate free radicals are intermediates in ligninase catalysis. Proc. Natl. Acad. Sci. USA 83:3708-12, 1986.

47. Korytowski, W., KALYANARAMAN, B., Menon, I. A., Sarna, T., and Sealy, R. C. Reaction of superoxide anions with melanins: electron spin resonance and spin trapping studies. Biochim. Biophys. Acta 882:145-53, 1986.

48. Hintz, P. and KALYANARAMAN, B. Metal ion-induced activation of molecular oxygen in pigmented polymers. Biochim. Biophys. Acta 883:41-5, 1986.

49. Pilas, B., Felix, C. C., Sarna, T., and KALYANARAMAN, B. Photolysis of pheomelanin precursors: an ESR-spin trapping study. Photochem. Photobiol. 44:689-96, 1986.

50. Ankel, E., Felix, C. C., and KALYANARAMAN, B. The use of spin label oximetry in the study of photodynamic inactivation of Chinese hamster ovary cells. Photochem. Photobiol. 44:741-6, 1986.

51. Hammel, K. E., KALYANARAMAN, B., and Kirk, T. K. Oxidation of polycyclic aromatic hydrocarbons and dibenzo[p]-dioxins by Phanerochaete chrysosporium ligninase. J. Biol. Chem. 261:16948-52, 1986.

52. Korytowski, W., Sarna, T., KALYANARAMAN, B., and Sealy, R. C. Tyrosinase-catalyzed oxidation of dopa and related catechol(amine)s: a kinetic electron spin resonance investigation using spin-stabilization and spin label oximetry. Biochim. Biophys. Acta 924:383-92, 1987 [Erratum: Biochim. Biophys. Acta 926:203, 1987].

53. Schreiber, J., Mottley, C., Sinha, B. K., KALYANARAMAN, B., and Mason, R. P. One-electron reduction of daunomycin, daunomycinone, and 7-deoxydaunomy¬cinone by the xanthine/xanthine oxidase system: Detection of semiquinone free radicals by electron spin resonance. J. Am. Chem. Soc. 109:348, 1987.

54. Katki, A. G., KALYANARAMAN, B., and Sinha, B. K. Interactions of the antitumor drug, etoposide, with reduced thiols in vitro and in vivo. Chem. Biol. Interact. 62:237-47, 1987.

55. Korytowski, W., Felix, C. C., and KALYANARAMAN, B. Mechanism of oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+). Biochem. Biophys. Res. Commun. 144:692-8, 1987.

56. Korytowski, W., Felix, C. C., and KALYANARAMAN, B. Evidence for the one-electron oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+). Biochem. Biophys. Res. Commun. 147:354-60, 1987.

57. KALYANARAMAN, B., Premovic, P. I., and Sealy, R. C. Semiquinone anion radicals from addition of amino acids, peptides, and proteins to quinones derived from oxidation of catechols and catecholamines. An ESR spin stabilization study. J. Biol. Chem. 262:11080-7, 1987.

58. Korytowski, W., Pilas, B., Sarna, T., and KALYANARAMAN, B. Photoinduced generation of hydrogen peroxide and hydroxyl radicals in melanins. Photochem. Photobiol. 45:185-90, 1987.

59. KALYANARAMAN, B., Feix, J. B., Sieber, F., Thomas, J. P., and Girotti, A. W. Photodynamic action of merocyanine 540 on artificial and natural cell membranes: involvement of singlet molecular oxygen. Proc. Natl. Acad. Sci. USA 84:2999-3003, 1987.

60. Menon, I. A., Basu, P. K., Persad, S., Avaria, M., Felix, C. C., and KALYANARAMAN, B. Is there any difference in the photobiological properties of melanins isolated from human blue and brown eyes? Br. J. Ophthalmol. 71:549-52, 1987.

61. Korytowski, W., Felix, C. C., and KALYANARAMAN, B. Oxygen activation during the interaction between MPTP metabolites and synthetic neuromelanin--an ESR-spin trapping, optical, and oxidase electrode study. Biochem. Biophys. Res. Commun. 154:781-8, 1988.

62. KALYANARAMAN, B., Korytowski, W., Pilas, B., Sarna, T., Land, E. J., and Truscott, T. G. Reaction between ortho-semiquinones and oxygen: pulse radiolysis, electron spin resonance, and oxygen uptake studies. Arch. Biochem. Biophys. 266:277-84, 1988.

63. Prabhananda, B. S., Felix, C. C., KALYANARAMAN, B., and Felix, C. C. Free radicals formed from the oxidation of 4-aminocatechol. Identification and structural dynamics using ESR spectroscopy. J. Magn. Reson. 76:264, 1988.

64. Sinha, B. K., Eliot, H. M., and KALYANARAMAN, B. Iron-dependent hydroxyl radical formation and DNA damage from a novel metabolite of the clinically active antitumor drug VP-16. FEBS Lett. 227:240-4, 1988.

65. Bernofsky, C., Olavesen, Y. E., Felix, C. C., and KALYANARAMAN, B. Evidence for a hydroperoxyl radical from hypochlorite-modified adenosine 5'-monophosphate (AMP). Biochem. Arch. 4:103-7, 1988.

66. Pilas, B., Sarna, T., KALYANARAMAN, B., and Swartz, H. M. The effect of melanin on iron associated decomposition of hydrogen peroxide. Free Radic. Biol. Med. 4:285-93, 1988.

67. Feix, J. B., KALYANARAMAN, B., Chignell, C. F., and Hall, R. D. Direct observation of singlet oxygen production by merocyanine 540 associated with phosphatidylcholine liposomes. J. Biol. Chem. 263:17247-50, 1988.

68. Hodnick, W. F., KALYANARAMAN, B., Pritsos, C. A., and Pardini, R. S. The production of hydroxyl and semiquinone free radicals during the autoxidation of redox active flavonoids. Basic Life Sci. 49:149-52, 1988.

69. KALYANARAMAN, B., Korytowski, W., and Felix, C. C. Mechanism of oxidation of 1-methyl-4-phenyl-3,3-dihydropyridinium (MPDP+). Basic Life Sci. 49:781-5, 1988.

70. Odier, E., Mozuch, M. D., KALYANARAMAN, B., and Kirk, T. K. Ligninase-mediated phenoxy radical formation and polymerization unaffected by cellobiose: quinone oxidoreductase. Biochimie 70:847-52, 1988 [Erratum: Biochimie 70:1126, 1988].

71. Baker, J. E., Felix, C. C., Olinger, G. N., and KALYANARAMAN, B. Myocardial ischemia and reperfusion: direct evidence for free radical generation by electron spin resonance spectroscopy. Proc. Natl. Acad. Sci. USA 85:2786-9, 1988.

72. Baker, J. E. and KALYANARAMAN, B. Ischemia-induced changes in myocardial paramagnetic metabolites: implications for intracellular oxy-radical generation. FEBS Lett. 244:311-4, 1989.

73. Feix, J. B. and KALYANARAMAN, B. Spin trapping of lipid-derived radicals in liposomes. Biochim. Biophys. Acta 992:230-5, 1989.

74. KALYANARAMAN, B., Sealy, R. C., and Liehr, J. G. Characterization of semiquinone free radicals formed from stilbene catechol estrogens. An ESR spin stabilization and spin trapping study. J. Biol. Chem. 264:11014-9, 1989.

75. KALYANARAMAN, B., Nemec, J., and Sinha, B. K. Characterization of free radicals produced during oxidation of etoposide (VP-16) and its catechol and quinone derivatives. An ESR study. Biochemistry 28:4839-46, 1989.

76. Athar, M., Mukhtar, H., Bickers, D. R., Kahn, I. U., and KALYANARAMAN, B. Evidence for the metabolism of tumor promoter organic hydroperoxides into free radicals by human carcinoma skin keratinocytes: an ESR-spin trapping study. Carcinogenesis 10:1499-503, 1989.

77. Pieper, G. M., Gross, G. J., and KALYANARMAN, B. An ESR study of the nitroxide radical of pentastarch-conjugated deferoxamine. Free Radic. Biol. Med. 9:211-8,1990.

78. Sinha, B. K., Antholine, W. E., KALYANARAMAN, B., and Eliot, H. M. Copper ion-dependent oxy-radical mediated DNA damage from dihydroxy derivative of etoposide. Biochim. Biophys. Acta 1096:81-3, 1990.

79. Sheng, P. G., Feix, J. B., and KALYANARAMAN, B. Characterization of radical adducts formed during photochemical spin trapping in liposomes. Photochem. Photobiol. 52:323-31 (1990).

80. Kersten, P. J., KALYANARAMAN, B., Hammel, K. E., Reinhammar, B., and Kirk, T. K. Comparison of lignin peroxidase, horseradish peroxidase and laccase in the oxidation of methoxybenzenes. Biochem. J. 268:475-80, 1990.

81. Popp, J. L., KALYANARAMAN, B., and Kirk, T. K. Lignin peroxidase oxidation of Mn2+ in the presence of veratryl alcohol, malonic or oxalic acid, and oxygen. Biochemistry 29:10475-80, 1990.

82. KALYANARAMAN, B., Antholine, W. E., and Parthasarathy, S. Oxidation of low-density lipoprotein by Cu2+ and lipoxygenase: an electron spin resonance study. Biochim. Biophys. Acta 1035:286-92, 1990.

83. KALYANARAMAN, B. and Baker, J. E. On the detection of paramagnetic species in the adriamycin-perfused rat heart: a reappraisal. Biochem. Biophys. Res. Commun. 169:30-8, 1990.

84. Kalyanarman, B., Morehouse, K. M., and Mason, R. P. An electron paramagnetic resonance study of the interactions between the adriamycin semiquinone, hydrogen peroxide, iron-chelators, and radical scavengers. Arch. Biochem. Biophys. 286:164-70, 1991.

85. Antholine, W. E., KALYANARAMAN, B., Templin, J. A., Brynes, R. W., and Petering, D. H. Spin-trapping studies of the oxidation-reduction reactions of iron bleomycin in the presence of thiols and buffer. Free Radic. Biol. Med. 10:119-23, 1991.

86. Roy, D., KALYANARAMAN, B., and Liehr, J. G. Xanthine oxidase-catalyzed reduction of estrogen quinones to semiquinones and hydroquinones. Biochem. Pharmacol. 42:1627-31, 1991.

87. Feix, J. B. and KALYANARAMAN, B. An electron spin resonance study of merocyanine 540-mediated type I reactions in liposomes. Photochem. Photobiol. 53:39-45, 1991.

88. Singh, R. J., Feix, J. B., Pintar, T. J., Girotti, A. W., and KALYANARAMAN, B. Photodynamic action of merocyanine 540 in artificial bilayers and natural membranes: action spectra and quantum yields. Photochem. Photobiol. 53:493-500, 1991.

89. Feix, J. B. and KALYANARAMAN, B. Production of singlet oxygen-derived hydroxyl radical adducts during merocyanine 540-mediated photosensitization: analysis by ESR-spin trapping and HPLC with electrochemical detection. Arch. Biochem. Biophys. 291:43-51, 1991.

90. Feix, J. B. and KALYANARAMAN, B. An electron spin resonance study of merocy-anine 540-mediated type I reactions in liposomes. Photochem. Photobiol. 53:39-45, 1991.

91. O'Brien, J. M., Singh, R. J., Feix, J. B., KALYANARAMAN, B., and Sieber, F. Action spectra of the antileukemic and antiviral activities of merocyanine 540. Photochem. Photobiol. 54:851-4, 1991.

92. Menon, I. A., Persad, S. D., Haberman, H. F., Basu, P. K., Norfray, J. F., Felix, C. C., and KALYANARAMAN, B. Characterization of the pigment from homogentisic acid and urine and tissue from an alkaptonuria patient. Biochem. Cell Biol. 69:269-73, 1991.

93. KALYANARAMAN, B., Parthasarathy, S., Joseph, J., and Froncisz, W. EPR spectra in a loop-gap resonator for a spin-trapped radical from a low-density lipoprotein. J. Magn. Reson. 92:342-7, 1991.

94. Towell, J. and KALYANARAMAN, B. Detection of radical adducts of 5,5-dimethyl-1-pyrroline n-oxide by the combined use of high-performance liquid chromatography with electrochemical detection and electron spin resonance. Anal. Biochem. 196:111-9, 1991.

95. Maruyama, M., Pieper, G. M., KALYANARAMAN, B., Hallaway, P. E., Hedlund, B. E., and Gross, G. J. Effects of hydroxyethyl starch conjugated deferoxamine on myocardial functional recovery following coronary occlusion and reperfusion in dogs. J. Cardiovasc. Pharmacol. 17:166-75, 1991.

96. KALYANARAMAN, B., Joseph, S., and Parthasarathy, S. The spin trap, alpha-phenyl N-tert-butylnitrone, inhibits the oxidative modification of low density lipoprotein. FEBS Lett. 280:17-20, 1991.

97. KALYANARAMAN, B., Joseph, J., Kondratenko, N., and Parthasarathy, S. Direct modification of low density lipoprotein by the spin trap 3,5-dibromo-4-nitrosobenzene sulfonic acid. Biochim. Biophys. Acta 1126:309-13, 1992.

98. KALYANARAMAN, B., Darley-Usmar, V. M., Wood, J., Joseph, J., and Parthasarathy, S. Synergistic interaction between the probucol phenoxyl radical and ascorbic acid in inhibiting the oxidation of low density lipoprotein. J. Biol. Chem. 267:6789-95, 1992.

99. Sugumaran, M., Semensi, V., KALYANARAMAN, B., Bruce, J. M., and Land, E. J. Evidence for the formation of a quinone methide during the oxidation of insect cuticular sclerotizing precusor 1,2-dehydro-N-acetyldopamine. J. Biol. Chem. 267:10355-61, 1992.

100. Singh, R. J., Feix, J. B., and KALYANARAMAN, B. Photobleaching of merocyanine 540: involvement of singlet molecular oxygen. Photochem. Photobiol. 55:483-9, 1992.

101. Anderson, M. S., KALYANARAMAN, B., and Feix, J. B. Enhancement of merocyanine 540-mediated phototherapy by salicylate. Cancer Res. 53:806-9, 1993.

102. KALYANARAMAN, B., Ramanujam, S., Singh, R. J., and Feix, J. B. Formation of 2,5-dihydroxybenzoic acid during the reaction between 1O2 and salicylic acid: Analysis by ESR oximetry and HPLC with electrochemical detection. J. Am. Chem. Soc. 115:4007-12, 1993.

103. Konorev, E. A., Baker, J. E., Joseph, J., and KALYANARAMAN, B. Vasodilatory and toxic effects of spin traps on aerobic cardiac function. Free Radic. Biol. Med. 14:127-37, 1993.

104. KALYANARAMAN, B., Joseph, J., and Parthasarathy, S. Site-specific trapping of reactive species in low-density lipoprotein oxidation: biological implications. Biochim. Biophys. Acta 1168:220-7, 1993.

105. KALYANARAMAN, B., Joseph, J., and Parthasarathy, S. The use of spin traps to investigate site-specific formation of free radicals in low-density lipoprotein oxidation. Biochem. Soc. Trans. 21:318-21, 1993. Review.

106. Joseph, J., KALYANARAMAN, B., and Hyde, J. S. Trapping of nitric oxide by nitronyl nitroxides: an electron spin resonance investigation. Biochem. Biophys. Res. Commun. 192:926-34, 1993.

107. Aust, S. D., Chignell, C. F., Bray, T. M., KALYANARAMAN, B., and Mason, R. P. Free radicals in toxicology. Toxicol. Appl. Pharmacol. 120:168-78, 1993. Review.

108. Pace, M. D. and KALYANARAMAN, B. Spin trapping of nitrogen dioxide radical from photolytic decomposition of nitramines. Free Radic. Biol. Med. 15, 337-42, 1993.

109. Konorev, E. A., Struck, A. T., Baker, J. E., Ramanujam, S., Thomas, J. P., Radi, R., and KALYANARAMAN, B. Intracellular catalase inhibition does not predispose rat heart to ischemia-reperfusion and hydrogen peroxide-induced injuries. Free Radic. Res. Commun. 19:397-407, 1993.

110. Graham, A., Hogg, N., KALYANARAMAN, B., O'Leary, V., Darley-Usmar, V., and Moncada, S. Peroxynitiric modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor. FEBS Lett. 330:181-6, 1993.

111. Hogg, N., KALYANARAMAN, B., Joseph, J., Struck, A., and Parthasarathy, S. Inhibition of low-density lipoprotein oxidatin by nitric oxide. Potential role in atherogenesis. FEBS Lett. 334:170-4, 1993.

112. Baker, J. E., Konorev, E. A., Tse, S. Y., Joseph, J., and KALYANARAMAN, B. Lack of protection of PBN in isolated heart during ischemia and reperfusion: implications for radical scavenging mechanism. Free Radic. Res. 20:145-63, 1994. [Erratum: Free Radic. Res. 20:411, 1994].

113. Thomas, C. E., Ku, G., and KALYANARAMAN, B. Nitrone spin trap lipophilicity as a determinant for inhibition of low density lipoprotein oxidation and activation of interleukin-1 beta release from human monocytes. J. Lipid Res. 35:610-9, 1994.

114. Feix, J. B., Anderson, M. S., and KALYANARAMAN, B. Enhancement of merocyanine 540 uptake and photodynamic cell killing by salicylates. Cancer Res. 54:3474-8, 1994.

115. Singh, R. J., Hogg, N., Mchaourab, H. S., and KALYANARAMAN, B. Physical and chemical interactions between nitric oxide and nitroxides. Biochim. Biophys. Acta 1201:437-41, 1994.

116. Hogg, N., Joseph, J., and KALYANARAMAN, B. The oxidation of alpha-tocopherol and trolox by peroxynitrite. Arch. Biochem. Biophys. 314:153-8, 1994.

117. Thomas, J. P., KALYANARAMAN, B., and Girotti, A. W. Involvement of preexisting lipid hydroperoxides in Cu2+-stimulated oxidation of low-density lipoprotein. Arch. Biochem. Biophys. 315:244-54, 1994.

118. Rubbo, H., Radi, R., Trujillo, M., KALYANARAMAN, B., Barnes, S., and Freeman, B. A. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation: formation of nitrogen-containing oxidized lipid derivatives. J. Biol. Chem. 269:26066-75, 1994.

119. Thomas, C. E., Ohlweiler, D. F., and KALYANARAMAN, B. Multiple mechanisms for inhibition of low density lipoprotein oxidation by novel cyclic nitrone spin traps. J. Biol. Chem. 269:28055-61, 1994.

120. Konorev, E. A., Tarpey, M. M., Joseph, J., Baker, J. E., and KALYANARAMAN, B. Nitronyl nitroxides as probes to study the mechanism of vasodilatory action of nitrovasodilators, nitrone spin traps, and nitroxides: role of nitric oxide. Free Radic. Biol. Med. 18:169-77, 1995.

121. Pieper, G. M., Felix, C. C., KALYANARAMAN, B., Turk, M., and Roza, A. M. Detection by ESR of DMPO hydroxyl adduct formation from islets of Langerhans. Free Radic. Biol. Med. 19:219-25, 1995.

122. Hogg, N., Singh, R. J., Joseph, J., Neese, F., and KALYANARAMAN, B. Reactions of nitric oxide with nitronyl nitroxides and oxygen: prediction of nitrite and nitrate formation by kinetic simulation. Free Radic. Res. 22:47-56, 1995.

123. Singh, R. J., Hogg, N., Neese, F., Joseph, J., and KALYANARAMAN, B. Trapping of nitric oxide formed during photolysis of sodium nitroprusside in aqueous and lipid phases: an electron spin resonance study. Photochem. Photobiol. 61:325-30 (1995).

124. KALYANARAMAN, B., Darley-Usmar, V., Struck, A., Hogg, N., and Parthasarathy, S. Role of apolipoprotein B-derived radical and alpha-tocopheroxyl radical in peroxidase-dependent oxidation of low density lipoprotein. J. Lipid Res. 36:1037-45, 1995.

125. Struck, A. T., Hogg, N., Thomas, J. P., and KALYANARAMAN, B. Nitric oxide donor compounds inhibit the toxicity of oxidized low-density lipoprotein to endothelial cells. FEBS Lett. 361:291-4, 1995.

126. Singh, R. J., Hogg, N., Joseph, J., and KALYANARAMAN, B. Photosensitized decomposition of S-nitrosothiols and 2-methyl-2-nitrosopropane: possible use for site-directed nitric oxide production. FEBS Lett. 360:47-51, 1995.

127. Rubbo, H., Parthasarathy, S., Barnes, S., Kirk, M, KALYANARAMAN, B., and Freeman, B. A. Nitric oxide nitrosation of lipoxygenase-dependent liposomal and lipoprotein oxidation: formation of nitrogen-containing oxidized lipid derivatives. J. Biol. Chem. 269:26066-75, 1995.

128. Singh, R. J., Feix, J. B., Mchaourab, H. S., Hogg, N., and KALYANARAMAN, B. Spin-labeling study of the oxidative damage to low-density lipoprotein. Arch. Biochem. Biophys. 320:155-61, 1995.

129. Konorev, E. A., Tarpey, M. M., Joseph, J., Baker, J. E., and KALYANARAMAN, B. S-nitrosoglutathione improves functional recovery in the isolated rat heart after cardioplegic ischemic arrest--evidence for a cardioprotective effect of nitric oxide. J. Pharmacol. Exp. Ther. 274:200-6, 1995.

130. Hogg, N., Struck, A., Goss, S. P., Santanam, N., Joseph, J., Parthasarathy, S., and KALYANARAMAN, B. Inhibition of macrophage-dependent low density lipoprotein oxidation by nitric-oxide donors. J. Lipid Res. 36:1756-62, 1995.

131. KALYANARAMAN, B., Konorev, E. A., Joseph, J., and Baker, J. E. Is free radical generation an important component of ischemia/reperfusion injury? Part 2. Redox Report 1:181-4, 1995.

132. Goss, S. P., Hogg, N., and KALYANARAMAN, B. The antioxidant effect of spermine NONOate in human low-density lipoprotein. Chem. Res. Toxciol. 8:800-6, 1995.

133. KALYANARAMAN, B. Radical intermediates during degradation of lignin-model compounds and environmental pollutants: an electron spin resonance study. Xenobiotica 25:667-75, 1995. Review.

134. Rubbo, H., Parthasarathy, S., Barnes, S., Kirk, M., KALYANARAMAN, B., and Freeman, B. A. Nitric oxide inhibition of lipoxygenase-dependent liposome and low-density lipoprotein oxidation: termination of radical chain propagation reactions and formation of nitrogen-containing oxidized lipid derivatives. Arch. Biochem. Biophys. 324:15-25, 1995.

135. Singh, R. J., Hogg, N., and KALYANARAMAN, B. Interaction of nitric oxide with photoexcited rose bengal: evidence for one-electron reduction of nitric oxide to nitroxyl anion. Arch. Biochem. Biophys. 324:367-73 (1995).

136. Konorev, E. A., Joseph, J., and KALYANARAMAN, B. S-nitrosoglutathione induces formation of nitrosylmyoglobin in isolated hearts during cardioplegic ischemia--an electron spin resonance study. FEBS Lett. 378:111-4, 1996.

137. Hogg, N., Singh, R. J., and KALYANARAMAN, B. The role of glutathione in the transport and catabolism of nitric oxide. FEBS Lett. 382:223-8, 1996.

138. Karoui, H., Hogg, N., Joseph, J., and KALYANARAMAN, B. Effect of superoxide dismutase mimics on radical adduct formation during the reaction between peroxynitrite and thiols--an ESR-spin trapping study. Arch. Biochem. Biophys. 330:115-24, 1996.

139. Karoui, H., Hogg, N., Frejaville, C., Tordo, P., and KALYANARAMAN, B. Characterization of sulfur-centered radical intermediates formed during the oxidation of thiols and sulfite by peroxynitrite: ESR-spin trapping and oxygen uptake studies. J. Biol. Chem. 271:6000-9, 1996.

140. Konorev, E. A., Joseph, J., Tarpey, M. M., and KALYANARAMAN, B. The mechanism of cardioprotection by S-nitrosoglutathione monoethyl ester in rat isolated heart during cardioplegic ischaemic arrest. Br. J. Pharmacol. 119:511-8, 1996.

141. Singh, R. J., Hogg, N., Joseph, J., and KALYANARAMAN, B. Mechanism of nitric oxide release from S-nitrosothiols. J. Biol. Chem. 271:18596-603, 1996.

142. Hogg, N., Singh, R. J., Goss, S. P. A., and KALYANARAMAN, B. The reaction between nitric oxide and alpha-tocopherol: a reappraisal. Biochem. Biophys. Res. Commun. 224:696-702, 1996.

143. KALYANARAMAN, B., Karoui, H., Singh, R. J., and Felix, C. C. Detection of thiyl radical adducts formed during hydroxyl radical- and peroxynitrite-mediated oxidation of thiols--a high resolution ESR spin-trapping study at Q-band (35 GHz). Anal. Biochem. 241:75-81, 1996.

144. Curtis, J. F., Reddy, N. G., Mason, R. P., KALYANARAMAN, B., and Eling, T. E. Nitric oxide: a prostaglandin H synthase 1 and 2 reducing cosubstrate that does not stimulate cyclooxygenase activity or prostaglandin H synthase expression in murine macrophages. Arch. Biochem. Biophys. 335:369-76, 1996.

145. Baker, J. E., Froncisz, W., Joseph, J., and KALYANARAMAN, B. Spin label oximetry to assess extracellular oxygen consumption during myocardial ischemia. Free Radic. Biol. Med. 22:109-15, 1997.

146. Hogg, N., Singh, R. J., Konorev, E., Joseph, J., and KALYANARAMAN, B. S-Nitrosoglutathione as a substrate for gamma-glutamyl transpeptidase. Biochem. J. 323:477-81, 1997.

147. V´asquez-Vivar, J., Hogg, N., Pritchard, K. A. Jr., Martasek, P., and KALYANARAMAN, B. Superoxide anion formation from lucigenin: an electron spin resonance spin-trapping study. FEBS Lett. 403:127-30, 1997.

148. Ferguson, E., Singh, R. J., Hogg, N., and KALYANARAMAN, B. The mechanism of apolipoprotein B-100 thiol depletion during oxidative modification of low-density lipoprotein. Arch. Biochem. Biophys. 341:287-94, 1997.

149. Karoui, H., Hansert, B., Sand, P. J., Tordo, P., Bohle, D. S., and KALYANARAMAN, B. Spin trapping of free radicals formed during the oxidation of glutathione by tetramethylammonium peroxynitrite. Nitric Oxide: Biology and Chemistry 1:346-58, 1997.

150. Nakanishi, A. L., Roza, A. M., Adams, M. B., Seibel, R., Moore-Hilton, G., KALYANARAMAN, B., and Pieper, G. M. Electron spin resonance analysis of heme-nitrosyl and reduced iron-sulfur centered complexes in allogeneic, heterotopic cardiac transplants--effects of treatment with pyrrolidine dithiocarbamate. Free Radic. Biol. Med. 25:201-7, 1998.

151. Goss, S. P. A., Hogg, N., and KALYANARAMAN, B. The effect of nitric oxide release rates on the oxidation of human low-density lipoprotein. J. Biol. Chem. 272:21647-53, 1997.

152. Smalley, D.M., Hogg, N., KALYANARAMAN, B., and Pritchard, K. A. Jr. Endothelial cells prevent accumulation of lipid hydroperoxides in low-density lipoprotein. Arterioscler. Thromb. Vasc. Biol. 17:3469-74, 1997.

153. V´asquez-Vivar, J., Martasek, P., Hogg, N., Masters, B. S. S., Pritchard, K. A. Jr., and KALYANARAMAN, B. Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin. Biochemistry 36:11293-7, 1997.

154. Ferguson, E., Parthasarathy, S., Joseph, J., and KALYANARAMAN, B. Generation and initial characterization of a novel polyclonal antibody directed against homocysteine thiolactone-mediated low-density lipoprotein. J. Lipid Res. 39:925-33, 1998.

155. Konorev, E. A., Hogg, N., and KALYANARAMAN, B. Rapid and irreversible inhibition of creatine kinase by peroxynitrite. FEBS Lett. 427:171-4, 1998.

156. Singh, R. J., Karoui, H., Gunther, M. R., Beckman, J. S., Mason, R. P., and KALYANARAMAN, B. Reexamination of the mechanism of hydroxyl radical adducts formed from the reaction between familial amyotrophic lateral sclerosis-associated Cu,Zn superoxide dismutase mutants and H2O2. Proc. Natl. Acad. Sci. USA 95:6675-80, 1998.

157. V´asquez-Vivar, J., KALYANARAMAN, B., Martasek, P., Hogg, N., Masters, B. S. S., Karoui, H., Tordo, P., and Pritchard, K. A. Jr. Superoxide generation by endothelial nitric oxide synthase--the influence of cofactors. Proc. Natl. Acad. Sci. USA 95:9220-5, 1998.

158. Singh, R. J., Goss, S. P. A., Joseph, J., and KALYANARAMAN, B. Nitration of gamma-tocopherol and oxidation of alpha-tocopherol by copper-zinc superoxide dismutase/H2O2/NO2 : Role of nitrogen dioxide free radical. Proc. Natl. Acad. Sci. USA 95:12912-7, 1998.

159. Hogg, N. and KALYANARAMAN, B. Nitric oxide and low-density lipoprotein oxidation. Free Radic. Res. 28:593-600, 1998. Review.

160. Baker, J.E., Holman, P., KALYANARAMAN, B., and Pritchard, K.A. Jr. Adaptation of hearts to chronic hypoxia increases tolerance to subsequent ischemia by increased nitric oxide production. Adv. Exp. Med. Biol. 454:203 17, 1998.

161. Singh, R. J., Hogg, N., Joseph, J., Konorev, E., and KALYANARAMAN, B. The peroxynitrite generator, SIN-1, becomes a nitric oxide donor in the presence of electron acceptors. Arch. Biochem. Biophys. 361:331-9, 1999.

162. Ferguson, E., Hogg, N., Antholine, W. E., Joseph, J., Singh, R. J., Parthasarathy, S., and KALYANARAMAN, B. Characterization of the adduct formed from the reaction between homocysteine thiolactone and low-density lipoprotein: antioxidant implications. Free Radic. Biol. Med. 26:968-77, 1999.

163. Goss, S. P. A., Hogg, N., and KALYANARAMAN, B. The effect of alpha-tocopherol on the nitration of gamma-tocopherol by peroxynitrite. Arch. Biochem. Biophys. 363, 333-40, 1999.

164. Janssen, Y. M. W., Soultanakis, R., Steece, K., Heerdt, E., Singh, R. J., Joseph, J., and KALYANARAMAN, B. Depletion of nitric oxide causes cell cycle alterations, apoptosis, and oxidative stress in pulmonary cells. Am. J. Physiol. 275 (Lung Cell. Mol. Physiol. 19): L1100-9, 1998.

165. Konorev, E. A., Kennedy, M. C., and KALYANARAMAN, B. Cell-permeable superoxide dismutase and glutathione peroxidase mimetics afford superior protection against doxorubicin-induced cardiotoxicity. Arch. Biochem. Biophys. 368:421-8, 1999.

166. Singh, R. J., Hogg, N., Goss, S. P. A., Antholine, W. E., and KALYANARAMAN, B. Mechanism of SOD/H2O2-mediated nitric oxide release from S-nitrosoglutathione--Role of glutamate. Arch. Biochem. Biophys. 372:8-15, 1999.

167. V´asquez-Vivar, J., Hogg, N., Martasek, P., Karoui, H., Pritchard, K. A. Jr., and KALYANARAMAN, B. Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase. J. Biol. Chem. 274:26736-42, 1999.

168. V´asquez-Vivar, J., Hogg, N., Martasek, P., Karoui, H., Tordo, P., Pritchard, K. A. Jr., and KALYANARAMAN, B. Effect of redox-active drugs on superoxide generation from nitric oxide synthases: biological and toxicological implications. Free Radic. Res. 31:607-17, 1999. Review.

169. Goss, S. P. A., Singh, R. J., Hogg, N., and KALYANARAMAN, B. Reactions of •NO, •NO2, and peroxynitrite in membranes: physiological implications. Free Radic. Res. 31:597-606, 1999. Review.

170. Goss, S. P. A., Singh, R. J., and KALYANARAMAN, B. Bicarbonate enhances the peroxidase activity of Cu,Zn-superoxide dismutase: role of carbonate anion radical. J. Biol. Chem. 274:28233-9, 1999.

171. Ferguson, E., Hogg, N., Antholine, W. E., Joseph, J., Singh, R. J., Parthasarathy, S., and KALYANARAMAN, B. Characterization of the adduct formed from the reaction between homocysteine thiolactone and low-density lipoprotein: antioxidant implications. Free Radic. Biol. Med. 26:968-77, 1999.

172. Singh, R. J., Hogg, N., Joseph, J., Konorev, E., and KALYANARAMAN, B. The peroxynitrite generator, SIN-1, becomes a nitric oxide donor in the presence of electron acceptors. Arch. Biochem. Biophys. 361:331-9, 1999.

173. Konorev, E. A., Kennedy, M. C., and KALYANARAMAN, B. Cell-permeable superoxide dismutase and glutathione peroxidase mimetics afford superior protection against doxorubicin-induced cardiotoxicity. Arch. Biochem. Biophys. 368:421-8, 1999.

174. V´asquez-Vivar, J., Hogg, N., Martasek, P., Karoui, H., Pritchard, K. A. Jr., and KALYANARAMAN, B. Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase. J. Biol. Chem. 274:26736-42, 1999.

175. Patel, R. P., Hogg, N., Spencer, N. Y., KALYANARAMAN, B., Matalon, S., and Darley-Usmar, V. M. Biochemical characterization of human S-nitrosohemoglobin. Effects on oxygen binding and transnitrosation. J. Biol. Chem. 274:15487-92, 1999.

176. Goss, S. P. A., Singh, R. J., and KALYANARAMAN, B. Bicarbonate enhances the peroxidase activity of Cu, Zn-superoxide dismutase. J. Biol. Chem. 274:28233-329, 1999.

177. Baker, J. E., Holman, P., KALYANARAMAN, B., Griffith, O. W., and Pritchard, K. A. Jr.: Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production. Ann. N.Y. Acad Sci. 874:236-53, 1999.

178. Hogg, N. and KALYANARAMAN, B. Nitric oxide and lipid peroxidation. Biochim. Biophys. Acta 1411:378-84, 1999. Review.

179. Zhang, H., Joseph, J., Felix, C., and KALYANARAMAN, B. Bicarbonate enhances the hydroxylation, nitration, and peroxidation reactions catalyzed by Cu, Zn-superoxide dismutase: Intermediacy of carbonate anion radical. J. Biol.Chem. 275:14038-45, 2000.

180. Konorev, E.A., KALYANARAMAN, B., and Hogg, N. Modification of creatine kinase by s-nitrosothiols: s-nitrosation vs. s-thiolation. Free Radic. Biol. Med. 28:1671-8, 2000.

181. Shi, Y., Pritchard, K. A., Holman, P., Rafiee, P., Griffith, O. W., KALYANARAMAN, B., and Baker, J. E. Chronic myocardial hypoxia increases nitric oxide synthase and decreases caveolin-3. Free Radic. Biol. Med. 29:695-703, 2000.

182. Konorev, E. A., Zhang, H., Joseph, J., Kennedy, M. C., and KALYANARAMAN, B. Bicarbonate exacerbates oxidative injury induced by antitumor antibiotic doxorubicin in cardiomyocytes. Am. J. Physiol. Heart Circ. Physiol. 279:H2424-30, 2000.

183. V´asquez-Vivar, J. and KALYANARAMAN, B. Generation of superoxide from nitric oxide synthase. FEBS Lett. 481:305-6, 2000.

184. Pritchard, K. A. Jr, Ackerman, A., and KALYANARAMAN, B. Chromium (VI) increases endothelial cell expression of ICAM-1 and decreases nitric oxide activity. J. Environ. Pathol. Toxicol. Oncol. 19:251-60, 2000.

185. Kotamraju, S., Konorev, E. A., Joseph, J., and KALYANARAMAN, B. Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species. J. Biol. Chem. 275, 33585-92, 2000.

186. Brzezinska, A.K., Gebremedhin, D., Chilian, W. M., KALYANARAMAN, B., and Elliot, S. J. Peroxynitrite reversibly inhibits CA(2+)-activated K(+) channels in rat cerebral artery smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 278:H1883-90, 2000.

187. Zhang, H., Joseph, J., V´asquez-Vivar, J., Karoui, H., Nsanzumuhire, C., Martasek, P., Tordo, P., and KALYANARAMAN, B. Detection of superoxide anion using an isotopically labeled nitrone spin trap: Potential biological implications. FEBS Lett. 473:58-62, 2000.

188. V´asquez-Vivar, J., KALYANARAMAN, B., and Kennedy, M. C. Mitochondrial aconitase as a source of hydroxyl radical. An electron spin resonance investigation. J. Biol. Chem. 275:14064-9, 2000.

189. Kotamraju, S., Hogg, N., Joseph, J., Keefer, L. K., and KALYANARAMAN, B. Inhibition of oxidized low-density lipoprotein-induced apoptosis in endothelial cells by nitric oxide: peroxyl radical scavenging as an antiapoptotic mechanism. J. Biol. Chem. 276:17316-23, 2001.

190. Zhang, H., Joseph, J., Feix, J., Hogg, N., and KALYANARAMAN, B. Nitration and oxidation of a hydrophobic tyrosine probe by peroxynitrite in membranes: comparison with nitration and oxidation of tyrosine by peroxynitrite in aqueous solution. Biochemistry 40:7675-86, 2001.

191. Baker, J. E., Contney, S. J., Singh, R., KALYANARAMAN, B., Gross, G. J., and Bosnjak, Z. J. Nitric oxide activates the sarcolemmal K(ATP) channel in normoxic and chronically hypoxic hearts by a cyclic GMP-dependent mechanism. J. Mol. Cell. Cardiol. 33:331-41, 2001.

192. Zhao, H., Joseph, J., Zhang, H., Karoui, H., and KALYANARAMAN, B. Synthesis and biochemical applications of a solid cyclic nitrone spin trap: a relatively superior trap for detecting superoxide anions and glutathiyl radicals. Free Radic. Biol. Med. 31, 599-606, 2001.

193. Kalivendi, S. V., Kotamraju, S., Zhao, H., Joseph, J., and KALYANARAMAN, B. Doxorubicin-induced apoptosis is associated with increased transcription of endothelial nitric oxide synthase: effect of antiapoptotic antioxidants and calcium. J. Biol. Chem. 276:47266-76, 2001.

194. V´asquez-Vivar, J., Whitsett, J., Mart´asek, P., Hogg, N., and KALYANARAMAN, B. Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical. Free Radic. Biol. Med. 31:975-85, 2001.

195. Patel, R. P., Boersma, B.J., Crawford, J. H., Hogg, N., Kirk, M., KALYANARAMAN, B., Parks, D. A., Barnes, S., and Darley-Usmar, V. Antioxidant mechanisms of isoflavones in lipid systems: paradoxical effects of peroxyl radical scavenging. Free Radic. Biol. Med. 31:1570-81, 2001.

196. Schroeder, P., Zhang, H., Klotz, L. O., KALYANARAMAN, B., and Sies, H. (-)-Epicatechin inhibits nitration and dimerization of tyrosine in hydrophilic as well as hydrophobic environments. Biochem. Biophys. Res. Commun. 289:1334-8, 2001.

197. KALYANARAMAN, B., Joseph, J., and Zhang, H. Bicarbonate enhances nitration and oxidation reactions in biological systems--role of reactive oxygen and nitrogen species. Adv. Exp. Med. Biol. 500:175-82, 2001. Review.

198. Zhang, H., Joseph, J., Gurney, M., Becker, D., and KALYANARAMAN, B. Bicarbonate enhances peroxidase activity of copper, zinc superoxide dismutase - role of carbonate anion radical and scavenging of carbonate anion radical by metalloporphyrin antioxidant enzyme mimetics. J. Biol. Chem. 277:1013-20, 2002.

199. V´asquez-Vivar, J., Mart´asek, P., Whitsett, J., Joseph, J., and KALYANARAMAN, B. The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study. Biochem. J. 362:733-9, 2002.

200. Zhu, B. Z., Zhao, H. T., KALYANARAMAN, B., and Frei, B. Metal-independent production of hydroxyl radicals by halogenated quinones and hydrogen peroxide: an ESR spin trapping study. Free Radic. Biol. Med. 32:465-73, 2002.

201. Kotamraju, S., Chitambar, C. R., Kalivendi, S. V., Joseph, J., and KALYANARAMAN, B. Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells. J. Biol. Chem. 277:17179-87, 2002.

202. KALYANARAMAN, B., Joseph, J., Kalivendi, S., Wang, S., Konorev, E., Kotamraju S. Doxorubicin-induced apoptosis: implications in cardiotoxicity. Mol. Cell. Biochem. 234-235:119-24, 2002.

203. Konorev, E., Kotamraju, S., Zhao, H., Kalivendi, S., Joseph, J., and KALYANARAMAN, B. Paradoxical effects of metalloporphyrins on doxorubicin-induced apoptosis: scavenging of reactive oxygen species versus induction of heme oxygenase-1. Free Radic. Biol. Med. 33:988-97, 2002.

204. V´asquez-Vivar, J., Duquaine, D., Whitsett, J., KALYANARAMAN, B., and Rajagopalan, S. Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants. Arterioscler. Thromb. Vasc. Biol. 22:1655-61, 2002.

205. Newman, D. K., Hoffman, S., Kotamraju, S., Zhao, T., Wakim, B., KALYANARAMAN, B., Newman, P. J. Nitration of PECAM-1 ITIM tyrosines abrogates phosphorylation and SHP-2 binding. Biochem. Biophys. Res. Commun. 296:1171-9, 2002.

206. Wang, S., Kotamraju, S., Konorev, E., Kalivendi, S., Joseph, J., KALYANARAMAN, B. Activation of nuclear factor-kappaB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: the role of hydrogen peroxide. Biochem. J. 367:729-40, 2002.

207. Tampo, Y., Kotamraju, S., Chitambar, C. R., Kalivendi, S. V., Keszler, A., Joseph, J., KALYANARAMAN, B. Oxidative stress-induced iron signaling is responsible for peroxide-dependent oxidation of dichlorodihydrofluorescein in endothelial cells. Circ. Res. 92:56-63, 2003.

208. V´asquez-Vivar, J., KALYANARAMAN, B., Mart´asek, P. The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications. Free Radic. Res. 37:121-7, 2003. Review.

209. Zhang, H., Bhargava, K., Keszler, A., Feix, J., Hogg, N., Joseph, J., KALYANARAMAN, B. Transmembrane nitration of hydrophobic tyrosyl peptides - localization, characterization, mechanism of nitration and biological implications. J. Biol. Chem. 278:8969-78, 2003.

210. Kalivendi, S. V., Kotamraju, S., Cunningham, S., Shang, T., Hillard, C. J., KALYANARAMAN, B. 1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferring-receptor-dependent iron and hydrogen peroxide. Biochem. J. 371:151-64, 2003.

211. Shang, T., Uihlein, A. V., Van Asten, J., KALYANARAMAN, B., Hillard, C. J. 1-Methyl-4-phenylpyridinium (MPP+) accumulates in cerebellar granule neurons via organic cation transporter-3 (OCT3). J. Neurochem. 85:358-67, 2003.

212. Zhao, H., Kalivendi, S., Zhang, H., Joseph, J., Nithipatikom, K., V´asquez-Vivar, J., KALYANARAMAN, B. Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide. Free Radic. Biol. Med. 34:1359-68, 2003.

213. Zhang, H., Andrekopoulos, C., Joseph, J., Chandran, K., Karoui, H. Crow, J. P., KALYANARAMAN, B. Bicarbonate-dependent peroxidase activity of human Cu,Zn-superoxide dismutase induces covalent aggregation of protein: Intermediacy of tryptophan-derived oxidation products. J. Biol. Chem. 278:24078-89, 2003.

214. Audi, S.H., Zhao, H., Bongard, R.D., Hogg, N., Kettenhofen, N.J., KALYANARAMAN, B., Dawson, C.A., Merker, M.P. Pulmonary arterial endothelial cells affect the redox status of coenzyme Q(0). Free Radic. Biol. Med. 34:892-907, 2003.

215. Rassaf, T., Bryan, N.S., Maloney, R.E., Specian, V., Kelm, M., KALYANARAMAN, B., Rodriguez, J., Feelisch, M. NO adducts in mammalian red blood cells: too much or too little? Nat. Med. 9:481-2, 2003; author reply 482-3.

216. Khan, N., Wilmot, C.M., Rosen, G.M., Demidenko, E., Sun, J., Joseph, J., O'Hara, J., KALYANARAMAN, B., Swartz, H.M. Spin traps: in vitro toxicity and stability of radical adducts. Free Radic. Biol. Med. 34:1473-81, 2003.

217. Ogawa, H., Rafiee, P., Heidemann, J., Fisher, P.J., Johnson, N.A., Otterson, M.F., KALYANARAMAN, B., Pritchard, K.A. Jr., Binion, D.G. Mechanisms of endotoxin tolerance in human intestinal microvascular endothelial cells. J. Immunol. 170:5956-64, 2003.

218. Liu, Y., Zhao, H., Li, H., KALYANARAMAN, B., Nicolosi, A.C., Gutterman, D.D. Mitochondrial sources of H2O2 generation play a key role in flow-mediated dilation in human coronary resistance arteries. Circ. Res. 93:573-80, 2003.

219. Kotamraju, S., Tampo, Y., Keszler, A., Chitambar, C.R., Joseph, J., Haas, A.L., KALYANARAMAN, B. Nitric oxide inhibits H2O2-induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. USA 100(19):10653-8, 2003.

220. Duquaine, D., Hirsch, G.A., Chakrabarti, A., Han, Z., Kehrer, C., Brook, R., Joseph, J., Schott, A., KALYANARAMAN, B., V´asquez-Vivar, J., Rajagopalan, S. Rapid-onset endothelial dysfunction with adriamycin: evidence for a dysfunctional nitric oxide synthase. Vasc. Med. 8:101-7, 2003.

221. Maas, M., Wang, R., Paddock, C., Kotamraju, S., KALYANARAMAN, B., Newman, P.J., Newman, D.K. Reactive oxygen species induce reversible PECAM-1 tyrosine phosphorylation and SHP-2 binding. Am. J. Physiol. Heart Circ. Physiol. 285:H2336-44, 2003.

222. Keszler, A., KALYANARAMAN, B., Hogg, N. Comparative investigation of superoxide trapping by cyclic nitrone spin traps: the use of singular value decomposition and multiple linear regression analysis. Free Radic. Biol. Med. 35:1149-57, 2003.

223. Kotamraju, S., Tampo, Y., Kalivendi, S.V., Joseph, J., Chitambar. C.R., KALYANARAMAN, B. Nitric oxide mitigates peroxide-induced iron signaling, oxidative damage, and apoptosis in endothelial cells: role of proteasomal function? Arch. Biophys. Biochem. 423:74-80, 2004. Review.

224. Shang, T., Kotamraju, S., Kalivendi, S.V., Hillard, C.J., KALYANARAMAN, B. 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric oxide synthase-derived superoxide. J. Biol. Chem. 279:19099-112, 2004.

225. Andrekopoulos, C., Zhang, H., Joseph, J., Kalivendi, S., KALYANARAMAN, B. Bicarbonate enhances alpha-synuclein oligomerization and nitration: intermediacy of carbonate radical anion and nitrogen dioxide radical. Biochem. J. 378:435-47, 2004.

226. Kalivendi, S.V., Cunningham, S. Kotamraju, S., Joseph, J., Hillard, C.J., KALYNARAMAN, B. Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: Intermediacy of transferrin receptor iron and hydrogen peroxide. J. Biol. Chem. 279:15240-7, 2004.

227. Wang, S., Konorev, E.A., Kotamraju, S., Joseph, J., Kalivendi, S., KALYANARAMAN, B. Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms: Intermediacy of H2O2- and p53-dependent pathways. J. Biol. Chem. 279:25535-43, 2004.

228. Kotamraju, S., Kalivendi, S.V., Konorev, E., Chitambar, C.R., Joseph, J., KALYANARAMAN, B. Oxidant-induced iron signaling in Doxorubicin-mediated apoptosis. Methods Enzymol. 378:362-82, 2004.

229. KALYANARAMAN, B. Introduction to the review series "Protein Radicals in Biological Systems--ESR Spin Trapping and Immuno Spin Trapping Approaches." Free Radic. Biol. Med. 36:1071, 2004.

230. Matsunaga, T., Kotamraju, S., Kalivendi, S.V., Dhanasekaran, A., Joseph, J., KALYANARAMAN, B. Ceramide-induced intracellular oxidant formation, iron signaling, and apoptosis in endothelial cells: protective role of endogenous nitric oxide. J. Biol. Chem. 279: 28614-24, 2004.

231. Karunakaran, C., Zhang, H., Crow, J.P., Antholine, W.E., KALYANARAMAN, B. Direct probing of copper active site and free radical formed during bicarbonate-dependent peroxidase activity of bovine and human copper, zinc superoxide dismutases: Low-temperature electron paramagnetic resonance and electron nuclear double resonance studies. J. Biol. Chem. 279:32534-40, 2004.

232. Zhang, H., Andrekopoulos, C., Joseph, J., Crow, J., KALYANARAMAN, B. The carbonate radical anion-induced covalent aggregation of human copper,zinc superoxide dismutase and alpha-synuclein - intermediacy of tryptophan- and tyrosine-derived oxidation products. Free Radic. Biol. Med. 36:1355-65, 2004. Review.

233. Merker, M.P., Bongard, R.D., Krenz, G.S., Zhao, H., Fernandes, V.S., KALYANARAMAN, B., Hogg, N., Sudi, S.H. Impact of pulmonary arterial cells on duroquinone redox status. Free Radic. Biol. Med. 37, 86-103, 2004.

234. KALYANARAMAN, B. Nitrated lipids: a class of cell-signaling molecules. Proc. Natl. Acad. Sci. USA 101:11527-8, 2004. Review.

235. Dhanasekaran, A., Kotamraju, S., Kalivendi, S.V., Matsunaga, T., Shang, T., Keszler, A., Joseph, J., KALYANARAMAN, B. Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis. J. Biol. Chem. 279:37575-87, 2004.

236. Zhang, H., Joseph, J., Crow, J., KALYANARAMAN, B. Mass spectral evidence for carbonate-anion-radical-induced posttranslational modification of tryptophan to kynurenine in human Cu, Zn superoxide dismutase. Free Radic. Biol. Med. 37:2018-26, 2004.

237. Kalivendi, S., Hatakeyama, K., Whitsett, J., Konorev, E., KALYANARAMAN, B., Vasquez-Vivar, J. Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide--A role for GFRP? Free Radic. Biol. Med. 38:481-91, 2005.

238. Trujillo, M., Folkes, L., Bartesaghi, S., KALYANARAMAN, B., Wardman, P., Radi, R. Peroxynitrite-derived carbonate and nitrogren dioxide radicals readily react with lipoic and dihydrolipoic acid. Free Radic. Biol. Med. 39:279-88, 2005.

239. Zhao, H., Joseph, J., Fales, H.M., Sokoloski, E.A., Levine, R.L., Vasquez-Vivar, J., KALYANARAMAN, B. Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence. Proc. Natl. Acad. Sci. USA 102:5727-32, 2005. [Erratum: Proc. Natl. Acad. Sci. USA 102:9086 (2005).]

240. Dhanasekaran, A., Kotamraju, S., Karunakaran, C., Kalivendi, S.V., Thomas, S., Joseph, J., KALYANARAMAN, B. Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide. Free Radic. Biol. Med. 39:567-83, 2005.

241. Shi, H., Timmins, G., Monske, M., Burdick, A., KALYANARAMAN, B., Liu, Y., Clement, J.L., Burchiel, S., Liu, K.J. Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species. Arch. Biochem. Biophys. 437:59-68, 2005.

242. Kalivendi, S.V., Konorev, E.A., Cunningham, S., Vanamala, S.K., Kaji, E.H., Joseph, J., KALYANARAMAN, B. Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: role of mitochondrial reactive oxygen species and calcium. Biochem. J. 389:527-39, 2005.

243. Karunakaran, C., Zhang, H., Joseph, J., Antholine, W.E., KALYANARAMAN, B. Thiol oxidase activity of copper, zinc superoxide dismutase stimulates bicarbonate-dependent peroxidase activity via formation of a carbonate radical. Chem. Res. Toxicol. 18:494-500, 2005.

244. Zielonka, J., Zhao, H., Xu, Y., KALYANARAMAN, B. Mechanistic similarities between oxidation at hydroethidine by Fremy's salt and superoxide: stopped-flow optical and EPR studies. Free Radic. Biol. Med. 39:853-63, 2005.

245. Shang, T., Joseph, J., Hillard, C.J., KALYANARAMAN, B. Death-associated protein kinase as a sensor of mitochondrial membrane potential - Role of lysosome in mitochondrial toxin induced cell death. J. Biol. Chem. 280, 34644-53, 2005.

246. Sun, G., Zhao, H., KALYANARAMAN, B., Dahms, N.M. Identification of residues essential for carbohydrate recognition and cation dependence of the 46 kDa mannose 6-phosphate receptor. Glycobiology 15:1136-49, 2005.

247. Porter, R., Jachymova, M., Martasek, P., KALYANARAMAN, B., Vasquez-Vivar, J. Reductive activation of Cr(Vi) by nitric oxide synthase. Chem. Res. Toxicol. 18:834-43, 2005.

248. Chi, L., Ke, Y., Luo, C., Li, B., Gozal, D., KALYANARAMAN, B., Liu, R. Motor neuron degeneration promotes neural progenitor cell proliferation, migration, and neurogenesis in the spinal cords of ALS mice. Stem Cells 24:34-43, 2006.

249. Zhang, H., Xu, Y., Joseph, J., KALYANARAMAN, B. Intramolecular electron transfer between tyrosyl radical and cysteine residue inhibits tyrosine nitration and induces thiyl radical formation in model peptides treated with myeloperoxidase, H2O2, and NO2-: EPR spin-trapping studies. J. Biol. Chem. 280:40684-98, 2005.

250. Kotamraju, S., Matalon, S., Matsunaga, T., Shang, T., Hickman-Davis, J.M., KALYANARAMAN, B. Upregulation of immunoproteasomes by nitric oxide: potential antioxidative mechanism in endothelial cells. Free Radic. Biol. Med. 40:1034-44, 2006.

251. Shang, T., Kotamraju, S., Zhao, H., Kalivendi, S.V., Hillard, C.J., KALYANARAMAN, B. Sepiapterin attenuates 1-methyl-4-phenylpyridinium-induced apoptosis in neuroblastoma cells transfected with neuronal NOS: Role of tetrahydrobiopterin, nitric oxide, and proteasome activation. Free Radic. Biol. Med. 39:1059-74, 2005.

252. Bartesaghi, S., Valez, V., Trujillo, M., Peluffo, G., Romero, N., Zhang, H., KALYANARAMAN, B., Radi, R. Mechanistic studies of peroxynitrite-mediated tyrosine nitration in membranes using the hydrophobic probe N-t-BOC L-tyrosine tert butyl ester (BTBE). Biochemistry 45:6813-25, 2006.

253. Huh, J., Liepins, A., Zielonka, J., Andrekopoulos, C., KALYANARAMAN, B., Sorokin, A. Cyclooxygenase 2 rescues LNCaP prostate cancer cells from sanguinarine-induced apoptosis by a mechanism involving inhibition of nitric oxide synthase activity. Cancer Res. 66:3726-36, 2006.

254. Zielonka, J., Vasquez-Vivar, J., KALYANARAMAN, B. The confounding effects of light, sonication and Mn(III)TBAP on quantitation of superoxide using hydroethidine. Free Radic. Biol. Med. 41:1050-7, 2006.

255. Whitsett, J., Martásek, P., Zhao H, Schauer DW, Hatakeyama K, KALYANARAMAN, B., Vásquez-Vivar J. Endothelial cell superoxide anion radical generation is not dependent on endothelial nitric oxide synthase-serine 1179 phosphorylation and endothelial nitric oxide synthase dimer/monomer distribution. Free Radic. Biol. Med. 40:2056-68, 2006.

256. Zielonka, J., Sarna, T., Roberts, J.E., Wishart, J.F., KALYANARAMAN, B. Pulse radiolysis and steady-state analyses of the reaction between hydroethidine and superoxide and other oxidants. Arch. Biochem. Biophys. 456:39-47 (2006). [PMCID: PMC2270254]

257. Watanabe, N., Zmijewski, J.W., Takabe, W., Umezu-Goto, M., LeGoffe, C., Sekine, A., Landar, A., Watanabe, A., Aoki, J., Arai, H., Kodama, T., Murphy, M.P., KALYANARAMAN, B., Darley-Usmar, V.M., Noguchi, N. Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells. Am. J. Pathol. 168:1737-48, 2006.

258. Borthiry, G.R., Antholine, W.E., KALYANARAMAN, B., Myers, J.M., Myers, C.R. Reduction of hexavalent chromium by human cytochrome b(5): Generation of hydroxyl radical and superoxide. Free Radic. Biol. Med. 42:738-55, discussion 735-7, 2007. [PMCID: PMC1993546]

259. Xu, Y., KALYANARAMAN, B. Synthesis and ESR studies of a novel cyclic nitrone spin trap attached to a phosphonium group--a suitable trap for mitochondria-generated ROS? Free Radic. Res. 41:1-7, 2007.

260. Thomas, S., Kotamraju, S., Zielonka, J., Harder, D.R., KALYANARAMAN, B. Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: a bell-shaped signaling response. Free Radic. Biol. Med. 42:1049-61, 2007. [PMCID: PMC2692187]

261. Horowitz, S., Binion, D.G., Nelson, V.M., Kanaa, Y., Javadi. P., Lazarova, Z., Andrekopoulos, C., KALYANARAMAN, B., Otterson, M.F., Rafiee, P. Increased arginase activity and endothelial dysfunction in human inflammatory bowel disease. Am. J. Physiol. Gastrointest. Liver Physiol. 292:G1323-36, 2007.

262. Bartesaghi, S., Ferrer-Sueta, G., Peluffo, G., Valez, V., Zhang, H., KALYANARAMAN, B., Radi, R. Protein tyrosine nitration in hydrophilic and hydrophobic environments. Amino Acids 32:501-15, 2007. Review.

263. Hardy, M., Chalier, F., Ouari, O., Finet, J.P., Rockenbauer, A., KALYANARAMAN, B., Tordo, P. Mito-DEPMPO synthesized from a novel NH2-reactive DEPMPO spin trap: a new and improved trap for the detection of superoxide. Chem. Commun. (Camb.) (10):1083-5, 2007

264. Zhu, B.Z., Zhao, H.T., KALYANARAMAN, B., Liu, J., Shan, G.Q., Du, Y.G., Frei, B. Mechanism of metal-independent decomposition of organic hydroperoxides and formation of alkoxyl radicals by halogenated quinones. Proc. Natl. Acad. Sci. USA 104(10):3698-702, 2007.

265. Hardy, M., Rockenbauer, A., Vasquez-Vivar, J., Felix, C., Lopez, M., Srinivasan, S., Avadhani, N., Tordo, P., KALYANARAMAN, B. Detection, characterization, and decay kinetics of ROS and thiyl adducts of mito-DEPMPO spin trap. Chem. Res. Toxicol. 20:1053-60, 2007. [NIHMSID: 515877]

266. Kotamraju, S., Williams, C.L., KALYANARAMAN, B. Statin-induced breast cancer cell death: Role of inducible nitric oxide and arginase-dependent pathways. Cancer Res. 67:7386-94, 2007.

267. Migrino, R.Q., Aggarwal, D., Konorev, E., Brahmbhatt, T., Bright, M., KALYANARAMAN, B. Early detection of doxorubicin cardiomyopathy using two-dimensional strain echocardiography. Ultrasound Med. Biol. 34:208-14, 2008. [PMCID: PMC2582214]

268. Romero, N., Peluffo, G., Bartesaghi, S., Zhang, H., Joseph, J., KALYANARAMAN, B., Radi, R. Incorporation of the hydrophobic probe N-t-BOC-L-tyrosine tert-butyl ester to red blood cell membranes to study peroxynitrite-dependent reactions. Chem. Res. Toxicol. 20:1638-48, 2007.

269. Zhu B.-Z., KALYANARAMAN, B., Jiang, G.-B. Molecular mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones. Proc. Natl. Acad. Sci. USA 104:17575-8, 2007. [PMCID: PMC2077033]

270. Zielonka, J., Srinivasan, S., Hardy, M., Ouari, O., Lopez, M., Vasquez-Vivar, J., Avadhani, N.G., KALYANARAMAN, B. Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: Identification of homo- and heterodimers. Free Radic. Biol. Med. 44:835-46, 2008. [PMCID: PMC2692199]

271. Zielonka, J., Vasquez-Vivar, J., KALYANARAMAN, B. Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine. Nat. Protoc. 3:8-21, 2008. PMID: 18193017

272. Matsunaga, T., Kamiya, T., Sumi, D., Kumagai, Y., KALYANARAMAN, B. L-Xylulose reductase is involved in 9,10-phenanthrenequinone-induced apoptosis in human T lymphoma cells. Free Radic. Biol. Med. 44:1191-202, 2008. PMID: 18206670

273. Vasquez-Vivar, J., Whitsett, J., Ionova, I., Konorev, E., Zielonka, J., KALYANARAMAN, B., Shi, Y., Pieper, G.M. Cytokines and Linduce inducible nitric oxide synthase but not enzyme activity in adult rat cardiomyocytes. Free Radic. Biol. Med. 45:994-1001, 2008. [PMCID: PMC2578873]

274. Konorev, E.A., Vanamala, S., KALYANARAMAN, B. Differences in doxorubicin-induced apoptotic signaling in adult and immature cardiomyocytes. Free Radic. Biol. Med. 45:1723-8, 2008. [PMCID: PMC3039518]

275. Bartesaghi, S., Peluffo, G., Zhang, H., Joseph, J., KALYANARAMAN, B., Radi, R. Tyrosine nitration, dimerization, and hydroxylation by peroxynitrite in membranes as studied by the hydrophobic probe N-t-BOC-l-tyrosine tert-butyl-ester. Methods Enzymol. 441:217-36, 2008. PMID: 18554537

276. Chandran, K., Aggarwal, D., Migrino, R.Q., Joseph, J., McAllister, D., Konorev, E.A., Antholine, W.E., Zielonka, J., Srinivasan, S., Avadhani, N.G., KALYANARAMAN, B. Doxorubicin inactivates myocardial cytochrome c oxidase in rats: Cardioprotection by Mito-Q. Biophys. J. 96:1388-98, 2009. [PMCID: PMC2717244]

277. Zielonka, J., Hardy, M., KALYANARAMAN, B. HPLC study of oxidation products of hydroethidine in chemical and biological systems: Ramifications in superoxide measurements. Free Radic. Biol. Med. 46:329-38, 2009. [PMCID: PMC3375818]

278. Zhang, H., Zielonka, J., Sikora, A., Joseph, J., Xu, Y., KALYANARAMAN, B. The effect of neighboring methionine residue on tyrosine nitration and oxidation in peptides treated with MPO, H2O2, and NO2- or peroxynitrite and bicarbonate: Role of intramolecular electron transfer mechanism? Arch. Biochem. Biophys. 484:134-45, 2009. [PMCID: PMC2874256]

279. Galati, D., Srinivasan, S., Raza, H., Prabu, S.K., Hardy, M., Chandran, K., Lopez, M., KALYANARAMAN, B., Avadhani, N.G. Role of nuclear encoded subunit Vb in the assembly and stability of cytochrome c oxidase complex: Implications in mitochondrial dysfunction and ROS production. Biochem. J. 420:439-49, 2009. [PMCID: PMC2735414]

280. Zhang, H., Andrekopoulos, C., Xu, Y., Joseph, J., Hogg, H., Feix, J., KALYANARAMAN, B. Decreased S-nitrosation of peptide thiols in the membrane interior. Free Radic. Biol. Med. 47:962-8, 2009. [PMCID: PMC2874255]

281. Zhu, B.Z., Shan, G.Q., Huang, C.H., KALYANARAMAN, B., Mao, L., Du, Y.G. Metal-independent decomposition of hydroperoxides by halogenated quinones: Detection and identification of a quinone ketoxy radical. Proc. Natl. Acad. Sci. USA 106:11466-71, 2009. [PMCID: PMC2710671]

282. Larson, M., Li, Z., Hall, C.L., Jensen, E., McAllister, D.M., KALYANARAMAN, B., Zhao, M. Physiological fluctuation of 99mTc-Sestamibi uptake in normal mammary glands: A systematic investigation in female rats. Acta Radiol. 50:975-8, 2009. PMID: 19636990

283. Sikora, A., Zielonka, J., Lopez, M., Joseph, J., KALYANARAMAN, B. Direct oxidation of boronates by peroxynitrite: Mechanism and implications in fluorescence imaging of peroxynitrite. Free Radic. Biol. Med. 47:1401-7, 2009. [PMCID: PMC3375817]

284. Weinberg, F., Hamanaka, R., Wheaton, W.W., Weinberg, S., Joseph, J., Lopez, M., KALYANARAMAN, B., Mutlu, G.M., Budinger, G.R., Chandel, N.S. Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc. Natl. Acad. Sci. USA 107:8788-93, 2010. [PMCID: PMC2889315]

285. Subramanian, S., KALYANARAMAN, B., Migrino, R.Q. Mitochondrially targeted antioxidants for the treatment of cardiovascular diseases. Recent Pat. Cardiovasc. Drug Discov. 5:54-65, 2010. Review. PMID: 19807685

286. Kalivendi, S.V., Yedlapudi, D., Hillard, C.J., KALYANARAMAN, B. Oxidants induce alternative splicing of alpha-synuclein: implications for Parkinson's disease. Free Radic. Biol. Med. 48:377-83, 2010. PMID: 19857570 NIHMS ID 640838

287. Li, Z., Lopez, M., Hardy, M., McAllister, D.M., KALYANARAMAN, B., Zhao, M. A 99mTc-labeled triphenylphosphonium derivative for the early detection of breast tumors. Cancer Biother. Radiopharm. 24:579-87, 2009. [PMCID: PMC2883499]

288. Diers, A.R., Higdon, A.N., Ricart, K.C., Johnson, M.S., Agarwal, A., KALYANARAMAN, B., Landar, A., Darley-Usmar, V.M. Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-Prostaglandin J2 increases apoptotic efficacy via redox cell signaling mechanisms. Biochem. J. 426:31-41, 2010. [PMCID: PMC3079364]

289. Zielonka, J., KALYANARAMAN, B. Hydroethidine- and Mito-SOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: Another inconvenient truth. Free Radic. Biol. Med. 48:983-1001, 2010. Review. [PMCID: PMC3587154]

290. Zielonka, J., Hardy, M., KALYANARAMAN, B. Corrigendum to "HPLC study of oxidation products of hydroethidine in chemical and biological systems: Ramifications in superoxide measurements". Free Radic. Biol. Med. 48:373, 2010. [PMCID: PMC3375818]

291. Bartesaghi, S., Wenzel, J., Trujillo, M., Lopez, M., Joseph, J., KALYANARAMAN, B., Radi, R. Lipid peroxyl radicals mediate tyrosine dimerization and nitration in membranes. Chem. Res. Toxicol. 23:821-35, 2010. [PMCID: PMC3506709]

292. Zielonka, J., Sikora, A., Joseph, J., KALYANARAMAN, B. Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide: Direct reaction with boronate-based fluorescent probe. J. Biol. Chem. 285:14210-6, 2010. Featured "Paper of the Week." [PMCID: PMC2863194]

293. Srinivasan, S., Koenigstein, A., Joseph, J., Sun, L., KALYANARAMAN, B., Zaidi, M., Avadhani, N.G. Role of mitochondrial ROS in osteoclast differentiation. Ann. N. Y. Acad. Sci. 1192:245-52, 2010. [PMCID: PMC2856121]

294. Dasgupta, J., Kar, S., Liu, R., Joseph, J., KALYANARAMAN, B., Remington, S.J., Chen, C., Melendez, J.A. Reactive oxygen species control senescence-associated matrix metaolloproteinase-1 through c-Jun-N-terminal kinase. J. Cell. Physiol. 225:52-62, 2010. [PMCID: PMC2913426]

295. Cheng, Q., Antholine, W.E., Myers, J.M., KALYANARAMAN, B., Arner, E.S., Myers, C.R. The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities. J. Biol. Chem. 285:21708-23, 2010. [PMCID: PMC2898413]

296. Khan, S.A., Nanduri, J., Yuan, G., Kinsman, B., Kumar, G.K., Joseph, J., KALYANARAMAN, B., Prabhakar, N.R. NADPH oxidase2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: Relevance to blood pressure changes in rats. Antioxid. Redox Signal. 14:533-42, 2011. [PMCID: PMC3038125]

297. Ghosh, A., Chandran, K., Kalivendi, S.V., Joseph, J., Antholine, W.E., Hillard, C.J., Kanthasamy, A., Kanthasamy, A., KALYANARAMAN, B. Neuroprotection by mitochondria-targeted drug in Parkinson's disease model. Free Radic. Biol. Med. 49:1674-84, 2010. [PMCID: PMC4020411]

298. Rao, A., Klein, S.R., Bonar, S.J., Zielonka, J., Mizuno, N., Dickey, J.S., Keller P.W., Joseph, J., KALYANARAMAN, B., Shacter, E. The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinine. J. Biol. Chem. 285:34447-59, 2010. [PMCID: PMC2966059]

299. Chacko, B., Reily, C., Srivastava, A., Johnson, M.S., Ulasova, E., Agarwal, A., Zinn, K., Murphy, M.P., KALYANARAMAN, B., Darley-Usmar, V. Prevention of diabetic nephropathy in Ins2+/-AkitaJ mice by the mitochondria-targeted therapy Mito-Q. Biochem. J. 432:9-19, 2010. [PMCID: PMC2973231]

300. Chandran, K., McCracken, J, Peterson, F.C., Antholine, W.E., Volkman, B.F., KALYANARAMAN, B. Oxidation of histidine residues in copper-zinc superoxide dismutase by bicarbonate stimulated peroxidase and thiol oxidase activities: Pulse EPR and NMR studies. Biochemistry 49:10616-22, 2010. [PMCID: PMC3501376]

301. Zhu, B.Z., Mao, L., Fan, R.M., Zhu, J.G., Zhang, Y.N., Wang, J., KALYANARAMAN, B., Frei, B. Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex. Chem. Res. Toxicol. 24:30-4, 2011. PMID: 21047085

302. Shchepin, R., Möller, M.N., Kim, H.Y., Hatch, D.M., Bartesaghi, S., KALYANARAMAN, B., Radi, R., Porter, N.A. Tryosine-lipid peroxidation adducts from radical termination: para coupling and intramolecular Diels-Alder cyclization. J. Am. Chem. Soc. 132:17490-500, 2010. [PMCID: PMC3677824]

303. Zhu, B.Z., Zhu, J.G., Mao, L., KALYANARAMAN, B., Shan, G.Q. Detoxifying carcinogenic polyhalogenated quinones by hydroxamic acids via an unusual double Lossen rearrangement mechanism. Proc. Natl. Acad. Sci. U.S.A. 107:20686-90, 2010. [PMCID: PMC2996439]

304. Kumar, S.N., Konorev, E.A., Aggarwal, D., KALYANARAMAN, B. Analysis of proteome changes in doxorubicin-treated adult rat cardiomyocyte. J. Proteomics 74:683-97, 2011. [PMCID: PMC3298037]

305. Sikora, A., Zielonka, J., Lopez, M., Dybala-Defratyka, A., Joseph, J., Marcinek, A., KALYANARAMAN, B. Reaction between peroxynitrite and boronates: EPR spin-trapping, HPLC analyses, and quantum mechanical study of the free radical pathway. Chem. Res. Toxicol. 24:687-97, 2011. Featured "In this Issue". [PMCID: PMC3743543]

306. Murphy, M.P., Holmgren, A., Larsson, N.G., Halliwell, B., Chang, C.J., KALYANARAMAN, B., Rhee, S.G., Thornally, P.J., Partridge, L, Gems, D., Nyström, T., Belousov, V., Schumacker, P.T., Winterbourn, C.C. Unraveling the biological roles of reactive oxygen species. Cell Metab. 13:361-6, 2011. PMID: 21459321

307. Cheng, G., Lopez, M., Zielonka, J., Hauser, A.D., Joseph, J., McAllister, D., Rowe, J.J., Sugg, S.L., Williams, C.L., KALYANARAMAN, B. Mitochondria-targeted nitroxides exacerbate Fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. Cancer Biol. Ther. 12:707-17, 2011. [PMCID: PMC3218525]

308. Chacko, B.K., Srivastava, A., Johnson, M., Benavides, G.A., Chang, M.J., Ye, Y., Jhala, N., Murphy, M.P., KALYANARAMAN, B., Usmar, V.D. The mitochondria-targeted ubiquinone MitoQ decreases ethanol-dependent micro and macro hepatosteoatosis. Hepatology 54:153-63, 2011. [PMCID: PMC3125473]

309. Trumbull, K.A., McAllister, D., Gandelman, M.M., Fung, W.Y., Lew, T., Brennan, L., Lopez, N. Morré J., KALYANARAMAN, B., Beckman, J.S. Diapocynin and apocynin administration fails to significantly extend survival in G93A SOD1 ALS mice. Neurobiol. Dis. 45:137-44, 2012. [PMCID: PMC3710723]

310. KALYANARAMAN, B. Oxidative chemistry of fluorescent dyes: Implications in the detection of reactive oxygen and nitrogen species. Biochem. Soc. Trans. 39:1221-5, 2011. PMID: 21936793 Review.

311. Tormos, K.V., Anso, E., Hamanaka, R.B., Eisenhart, J., Joseph, J., KALYANARAMAN, B., Chandel, N.S. Mitochondrial complex III ROS regulate adipocyte differentiation. Cell Metab. 14:537-44, 2011. [PMCID: PMC3190168]

312. KALYANARAMAN, B., Darley-Usmar, V., Davies, K.J., Dennery, P.A., Forman, H.J., Grisham, M.B., Mann, G.E., Moore, K., Roberts, L.J. II, Ischiropoulos, H. Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic. Biol. Med. 52:1-6, 2012. [PMCID: PMC3911769]

313. Mukhopadhyay, P., Horvath, B., Zsengeller, Z., Zielonka, J., Tanchian, G., Holovac, E., Kechrid, M., Patel, V., Stillman, I.E., Parikh, S.M., Joseph, J., KALYANARAMAN, B., Pacher, P. Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy. Free Radic. Biol. Med. 52:497-506, 2012. [PMCID: PMC3253235]

314. Zielonka, J., Zielonka, M., Sikora, A., Adamus, J., Hardy, M., Ouari, O., Dranka, B.P., KALYANARAMAN, B. Global profiling of reactive oxygen and nitrogen species in biological systems: High-throughput real-time analyses. J. Biol. Chem. 287:2984-95, 2011. Featured "Paper of the Week". [PMCID: PMC3270955]

315. Soberanes, S., Gonzalez, A., Urich, D., Chiarella, S.E., Radigan, K.A., Osornio-Vargas, A., Joseph, J., KALYANARAMAN, B., Ridge, K.M., Chandel, N.S., Mutlu, G.M., De Vizcaya-Ruiz, A., Budinger, G.R.S. Particulate matter air pollution induces hypermethylation of the p16 promoter via a mitochondrial ROS-JNK-DNMT1 pathway. Sci. Rep. 2:275, 2012. [PMCID: PMC3281276]

316. Bansal, S., Srinivasan, S., Anandasadagopan, S., Chowdhury, A.R., Selvaraj, .V, KALYANARAMAN, B., Joseph, J., Avadhani, N.G. Additive effects of mitochondria-targeted Cytochrome P4502E1 and alcohol toxicity on cytochrome c oxidase function and the stability of respirosome complexes. J. Biol. Chem. 287:15284-97, 2012. [PMCID: PMC3346148]

317. Cheng, G., Zielonka, J., Dranka, B.P., McAllister, D., Mackinnon, A.C. Jr., Joseph, J., KALYANARAMAN, B. Mitochondria targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death. Cancer Res. 72:2634-44, 2012. [PMCID: PMC3700358]

318. Zsengellér, Z.K., Ellezian, L., Brown, D., Horváth, B., Mukhopadhyay, P., KALYANARAMAN, B., Parikh, S.M., Karumanchi, S.A., Stillman, I.E., Pacher, P. Cisplatin nephrotoxicity involves mitochondrial injury with impaired tubular mitochondrial enzyme activity. J. Histochem. Cytochem. 60:521-9, 2012. [PMCID: PMC3460350]

319. Petruk, A.A., Bartesaghi, S., Trujillo, M., Estrin, D.A., Murgida, D., KALYANARAMAN, B., Marti, M.A., Radi, R. Molecular basis of intramolecular electron transfer in proteins during radical-mediated oxidations: Computer simulation studies in model tyrosine-cysteine peptides in solution. Arch. Biochem. Biophys. 525:82-91, 2012. [PMCID: PMC3414218]

320.

321. Zielonka, J., Sikora, A., Hardy, M., Joseph, J., Dranka, B.P., KALYANARAMAN, B. Boronate probes as diagnostic tools for real time monitoring of peroxynitrite and hydroperoxides. Chem. Res. Toxicol. 25:1793-9, 2012. [PMCID: PMC3501381]

322. Dranka, B.P., Zielonka, J., Kanthasamy, A.G., KALYANARAMAN, B. Alterations in bioenergetics function induced by Parkinson's disease mimetic compounds: Lack of correlation with superoxide generation. J. Neurochem. 122:941-51, 2012. [PMCID: PMC3423581]

323. Zhu, B.Z., Mao, L., Huang, C.H., Qin, H., Fan, R.M., KALYANARAMAN, B., Zhu, J.G. Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated quinoid carcinogens and H2O2. Proc. Natl. Acad. Sci. USA 109:16046-51, 2012. [PMCID: PMC3479549]

324. Cunniff, B., Benson, K., Stumpff, J., Newick, K., Held, P., Taatjes, D., Joseph, J., KALYANARAMAN, B., Heintz, N.H. Mitochondrial-targeted nitroxides disrupt mitochondrial architecture and inhibit expression of peroxiredoxin 3 and FOXM1 in malignant mesothelioma cells. J. Cell. Physiol. 228:835-45, 2013. [PMCID: PMC3928986]

325. Michalski, R., Zielonka, J., Hardy, M., Joseph, J., KALYANARAMAN, B. Hydropropidine: A novel, cell-impermeant fluorogenic probe for detecting extracellular superoxide. Free Radic. Biol. Med. 54:135-47, 2013. [PMCID: PMC3711142]

326. Ghosh, A., Kanthasamy, A., Joseph, J., Anantharam, V., Srivastava, P., Dranka, B.P., KALYANARAMAN, B., Kanthasamy, A.G. Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease. J. Neuroinflammation 9(1):241-, 2012. [PMCID: PMC3488558]

327. Valez, V., Cassina, A., Batinic-Haberle, I., KALYANARAMAN, B., Ferrer-Sueta, G., Radi, R. Peroxynitrite formation in nitric oxide-exposed submitochondrial particles: Detection, oxidative damage and catalytic removal by Mn-porphyrins. Arch. Biochem. Biophys. 529:45-54, 2013. [PMCID: PMC3534903]

328. Shao, J., Huang, C.H., KALYANARAMAN, B., Zhu, B.Z. Potent methyl oxidation of 5-methyl-2'-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism. Free Radic. Biol. Med. 60:177-82, 2013. [PMCID: PMC4476646]

329. Myers, J.M., Cheng, Q., Antholine, W., KALYANARAMAN, B., Filipofska, A., Arner, E., Myers, C.R. Redox activation of Fe(III)-thiosemicarbazones and Fe(III)-bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping. Free Radic. Biol. Med. 60:183-94, 2013. [PMCID: PMC3654041]

330. Sikora, A., Zielonka, J., Adamus, J., Debski, D., Dybala-Defratyka, A., Michalowski, B., Joseph, J., Hartley, R.C., Murphy, M.P., KALYANARAMAN, B. Reaction between peroxynitrite and triphenylphosphonium-substituted arylboronic acid isomers: identification of diagnostic marker products and biological implications. Chem. Res. Toxicol. 26:856-67, 2013. [PMCID: PMC3700382]

331. KALYANARAMAN, B., Dranka, B.P., Hardy, M., Michalski, R., Zielonka, J. HPLC-based monitoring of products formed from hydroethidine-based fluorogenic probes - The ultimate approach for intra-and extracellular superoxide detection. Biochim. Biophys. Acta 1840:739-44, 2014. [PMCID: PMC3858408]

332. KALYANARAMAN, B. Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms. Redox Biol. 1:244-57, 2013. [PMCID: PMC3757692]

333. Dranka, B.P., Gifford, A., Ghosh, A., Zielonka, J., Joseph, J., Kanthasamy, A.G., KALYANARAMAN, B. Diapocynin prevents early Parkinson's disease symptoms in the Leucine-Rich Repeat Kinase 2 (LRRK2R1441G) transgenic mouse. Neurosci. Lett. 549:57-62, 2013. [PMCID: PMC3729885]

334. Qin, H., Huang, C.H., Mao, L., Xia, H.Y., KALYANARAMAN, B., Shao, J., Shan, G.Q., Zhu, B.Z. Molecular mechanism of metal-independent decomposition of lipid hydroperoxide 13-HPODE by halogenated quinoid carcinogens. Free Radic. Biol. Med. 63:459-66, 2013. PMID: 23680403

335. Ntantie, E., Gonyo, P., Lorimer, E.L., Hauser, A.D., Schuld, N., McAllister, D., KALYANARAMAN, B., Dwinell, M.B., Auchampach, J.A., Williams, C.L. An Adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering. Sci. Signal. 2013 May 28;6(277):ra39. doi: 10.1126/scisignal.2003374. [PMCID: PMC4278376]

336. Cheng, G., Zielonka, J., McAllister, D.M., Mackinnon, A.C. Jr, Joseph, J., Dwinell, M.B., KALYANARAMAN, B. Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promotes cell death. BMC Cancer 2013 Jun 13;13(1):285. doi: 10.1186/1471-2407-13-285. [PMCID: PMC3686663]

337. Dickey, J.S., Gonzalez, Y., Aryal, B., Mog, S., Nakamura, A.J., Redon, C.E., Baxa, U., Rosen, E., Cheng, G., Zielonka, J., Parekh, P., Mason, K.P., Joseph, J., KALYANARAMAN, B., Bonner, W., Herman, E., Shacter, E., Rao, V.A. Mito-Tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model. PLoS ONE 8(8):e70575, 2013. [PMCID: PMC3734284]

338. Dilip, A., Cheng, G., Joseph, J., Kunnimalaiyaan, S., KALYANARAMAN, B., Kunnimalaiyaan, M., Gamblin, T.C. Mitochondria-targeted antioxidant and glycolysis inhibition - Synergistic therapy in hepatocellular carcinoma. Anti-Cancer Drugs 24:881-8, 2013. [PMCID: PMC4028966]

339. Huang, C.H., Shan, G.Q., Mao, L., KALYANARAMAN, B., Qin, H., Ren, F.R., Zhu, B.Z. The first purification and unequivocal characterization of the radical form of the carbon-centered quinone ketoxy radical adduct. Chem. Commun. (Camb.) 49:6436-8, 2013. PMID: 23752136

340. Shah, G., Zhang, G., Chen, F., Cao, Y., KALYANARAMAN, B., See, W. Loss of BCG viability adversely affects the direct response of urothelial carcinoma cells to BCG exposure. J. Urol. 191:823-9, 2014. PMID: 24035882

341. Shah, G., Zhang, G., Chen, F., Cao, Y., KALYANARAMAN, B., See, W.A. iNOS expression and NO production contribute to the direct effects of BCG on urothelial carcinoma cell biology. Urol. Oncol. 32:45.e1-9, 2014. PMID: 24054867

342. Jin H, Kanthasamy A, Ghosh A, Anantharam V, KALYANARAMAN, B., Kanthasamy AG. Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes. Biochim. Biophys. Acta 184:1282-94, 2014. [PMCID: PMC3961561; Available on 2015-08-01]

343. Zielonka, J., Lambeth, J.D., KALYANARAMAN, B. On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: A re-evaluation. Free Radic. Biol. Med. 65:1310-4, 2013. [PMCID: PMC4274999]

344. Srinivasan, S., Spear, J., Chandran, K., Joseph, J., KALYANARAMAN, B., Avadhani, N.G. Oxidative stress induced mitochondrial protein kinase a mediates cytochrome C oxidase dysfunction. PLoS One 2013 Oct 10;8(10):e77129. doi: 10.1371/journal.pone.0077129. [PMCID: PMC3795003]

345. Michalski, R., Michalowski, B., Sikora, A., Zielonka, J., KALYANARAMAN, B. On the use of fluorescence lifetime imaging and dihydroethidium to detect superoxide in intact animals and ex vivo tissues: A reassessment. Free Radic. Biol. Med. 67:278-84, 2014. [PMCID: PMC4275029]

346. Koto, T., Michalski, R., Zielonka, J., Joseph, J., KALYANARAMAN, B. Detection and identification of oxidants formed during •NO/O2•- reaction: A multi-well plate CW-EPR spectroscopy combined with HPLC analyses. Free Radic. Res. 48:478-86, 2014. [PMCID: PMC4780754]

347. Mouradian, M., Kikawa, K.D., Dranka, B.P., Komas, S.M., KALYANARAMAN, B., Pardini, R.S. Docosahexaenoic acid attenuates breast cancer cell metabolism and the Warburg phenotype by targeting bioenergetic function. Mol. Carcinog. 54:810-20, 2015. PMID: 24729481

348. Kumar, A., Chen, S.H., Kadiiska, M.B., Hong, J.S., Zielonka, J., KALYANARAMAN, B., Mason, R.P. Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells. Free Radic. Biol. Med. 73:51-9, 2014. [PMCID: PMC4111989; Available on 2015/8/1]

349. Cheng G, Zielonka J, McAllister D, Tsai S, Dwinell MB, KALYANARAMAN B. Profiling and targeting of cellular bioenergetics: Inhibition of pancreatic cancer cell proliferation. Br. J. Cancer 111:85-93, 2014. [PMCID: PMC4090735]

350. Zielonka J, Cheng G, Zielonka M, Ganesh T, Sun A, Joseph J, Michalski R, O'Brien WJ, Lambeth JD, KALYANARAMAN B. High-throughput assays for superoxide and hydrogen peroxide: Design of a screening workflow to identify inhibitors of NADPH oxidases. J. Biol. Chem. 289:16176-89, 2014. [PMCID: PMC4047388]

351. Hardy M, Poulhès F, Rizzato E, Rockenbauer A, Banaszak K, Karoui H, Lopez M, Zielonka J, Vasquez-Vivar J, Sethumadhavan S, KALYANARAMAN, B, Tordo P, Ouari O. Mitochondrial targeted spin traps: synthesis, superoxide spin trapping and mitochondrial uptake. Chem. Res. Toxicol. 27:1155-65, 2014. PMID: 24890552

352. Michalski R, Zielonka J, Gapys E, Marcinek A, Joseph J, KALYANARAMAN, B. Real time measurements of amino acid and protein hydroperoxides using coumarin boronic acid. J. Biol. Chem. 289:22536-53, 2014. [PMCID: PMC4139259]

353. Dranka BP, Gifford A, McAllister D, Zielonka J, Joseph J, O'Hara CL, Stucky CL, Kanthasamy AG, KALYANARAMAN, B. A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2R1441G) transgenic mouse model of Parkinson's disease. Neurosci. Lett. 583:159-64, 2014. [PMC4253647]

354. Pan J, Zhang Q, Liu Q, Komas SM, KALYANARAMAN, B, Lubet RA, Wang Y, You M. Honokiol inhibits lung tumorigenesis through inhibition of mitochondrial function. Cancer Prev. Res. (Phila.) 7:1149-59, 2014. PMID: 25245764

355. Shah G, Zielonka J, Chen F, Zhang G, Cao Y, KALYANARAMAN, B, See W. H2O2 Generation by bacillus Calmette-Guérin induces the cellular oxidative stress response required for bacillus Calmette-Guérin direct effects on urothelial carcinoma biology. J. Urol. 192:1238-48, 2014. PMID: 24928267

356. Smulik R, Debski D, Zielonka J, Michałowski B, Adamus J, Marcinek A, KALYANARAMAN, B, Sikora A. Nitroxyl (HNO) reacts with molecular oxygen and forms peroxynitrite at physiological pH: Biological implications. J. Biol. Chem. 289:35570-81, 2014. [PMCID: PMC4271240; Available on 2015/12/19]

357. Forman HJ, Augusto O, Brigelius-Flohe R, Dennery PA, KALYANARAMAN B, Ischiropoulos H, Mann GE, Radi R, Jackson Roberts L 2nd, Vina J, Davies KJ. Even free radicals should follow some rules: A suggested guide to free radical research terminology and methodology. Free Radic. Biol. Med. 78:233-5, 2014. PMID: 25462642

358. Zielonka J, Sikora A, Adamus J, KALYANARAMAN B. Detection and differentiation between peroxynitrite and hydroperoxides using mitochondria-targeted arylboronic acid. Methods Mol. Biol. 1264:171-81, 2015. [PMCID: PMC4451192; Available on 2016-01-01]

359. Zhang Q, Pan J, Lubet RA, Komas SM, KALYANARAMAN B, Wang Y, You M. Enhanced Antitumor activity of 3-bromopyruvate in combination with rapamycin in vivo and in vitro. Cancer Prev. Res. (Phila.) 8:318-26, 2015. PMID: 25644152

360. Cheng G, Zielonka J, McAllister D, Hardy M, Ouari O, Joseph J, Dwinell MB, KALYANARAMAN B. Antiproliferative effects of mitochondria-targeted cationic antioxidants and analogs: role of mitochondrial bioenergetics and energy-sensing mechanism. Cancer Lett. 365:96-106, 2015. [PMCID: PMC4476640; Available on 2016-08-28]

361. Das S, Alhasson F, Dattaroy D, Pourhoseini S, Seth RK, Nagarkatti M, Nagarkatti PS, Michelotti GA, Diehl AM, KALYANARAMAN B, Chatterjee S. NADPH oxidase-derived peroxynitrite drives inflammation in mice and human nonalcoholic steatohepatitis via TLR4-lipid raft recruitment. Am. J. Pathol. 185:1944-57, 2015. [PMCID: PMC4483465; Available on 2016-07-01]

362. Mao L, Liu YX, Huang CH, Gao HY, KALYANARAMAN B, Zhu BZ. Intrinsic Chemiluminescence generation during advanced oxidation of persistent halogenated aromatic carcinogens. Environ. Sci. Technol. 49:7940-7, 2015. PMID: 26009932

363. Roy I, McAllister DM, Gorse E, Dixon K, Piper CT, Zimmerman NP, Getschman AE, Tsai S, Engle DD, Evans D, Volkman BF, KALYANARAMAN B, Dwinell MB. Pancreatic cancer cell migration and metastasis is regulated by chemokine-biased agonism and bioenergetic signaling. Cancer Res. 75:3529-42, 2015. [PMCID: PMC4560104; Available on 2016-09-01]

364. Ghosh A, Langley MR, Harischandra D, Neal ML, Jin H, Anantharam V, Joseph J, Brenza T, Narsimhan B, Kanthasamy A, KALYANARAMAN B, Kanthasamy AG. Mitoapocynin treatment protects againsts neuroinflammation and dopaminergic neurodegeneration in a preclinical animal model of Parkinson's disease. J. Neuroimmune Pharmacol. (in press, 2016).

365. Shah G, Zhang G, Chen F, Cao Y, KALYANARAMAN B, See WA. The Dose-Response Relationship of BCG on Urothelial Carcinoma Cell Biology. J. Urol. 2015 Dec 13. pii: S0022-5347(15)05423-3. doi: 10.1016/j.juro.2015.11.073. [Epub ahead of print] PMID: 26694905

366. Zielonka J, Zielonka M, VerPlank L, Cheng G, Hardy M, Ouari O, Ayhan MM, Podsiadly R, Sikora A, Lambeth JD, KALYANARAMAN B. Mitigation of NADPH Oxidase 2 Activity as a Strategy to Inhibit Peroxynitrite Formation. J. Biol. Chem. 291:7029-44, 2016. [PMCID: PMC4807286; Available on 2017-03-25]

367. Dębski D, Smulik R, Zielonka J, Michałowski B, Jakubowska M, Dębowska K, Adamus J, Marcinek A, KALYANARAMAN B, Sikora A. Mechanism of oxidative conversion of Amplex® Red to resorufin: Pulse radiolysis and enzymatic studies. Free Radic. Biol. Med. 95:323-32, 2016. PMID: 27021961

368. Cheng G, Zielonka J, Ouari O, Lopez M, McAllister D, Boyle K, Barrios CS, Weber JJ, Johnson BD, Hardy M, Dwinell MB, KALYANARAMAN B. Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells. Cancer Res 76:3904-15, 2016. [PMCID: PMC4930686; Available on 2017-07-01]

369. Zielonka J, Podsiadly R, Zielonka M, Hardy M, KALYANARAMAN B. On the use of peroxy-caged luciferin (PCL-1) probe for bioluminescent detection of inflammatory oxidants in vitro and in vivo - Identification of reaction intermediates and oxidant-specific minor products. Free Radic Biol Med 99:32-42, 2016.

370. Gao HY, Mao L, Li F, Xie LN, Huang CH, Shao J, Shao B, Kalyanaraman B, Zhu BZ. Mechanism of Intrinsic Chemiluminescence Production from the Degradation of Persistent Chlorinated Phenols by the Fenton System: A Structure-Activity Relationship Study and the Critical Role of Quinoid and Semiquinone Radical Intermediates. Environ Sci Technol. 2017 Mar 07;51(5):2934-2943. PMCID: PMC5806603

371. Zhao B, Qiang L, Joseph J, Kalyanaraman B, Viollet B, He YY. Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival. Genes Dis. 2016 Mar;3(1):82-87. PMCID: PMC5215801

372. Brenza TM, Ghaisas S, Ramirez JEV, Harischandra D, Anantharam V, Kalyanaraman B, Kanthasamy AG, Narasimhan B. Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy. Nanomedicine. 2017 Apr;13(3):809-820. PMCID: PMC5392427

373. Kalyanaraman B, Hardy M, Zielonka J. A Critical Review of Methodologies to Detect Reactive Oxygen and Nitrogen Species Stimulated by NADPH Oxidase Enzymes: Implications in Pesticide Toxicity. Curr Pharmacol Rep. 2016 Aug;2(4):193-201. PMCID: PMC5070669

374. Zielonka J, Hardy M, Michalski R, Sikora A, Zielonka M, Cheng G, Ouari O, Podsiadły R, Kalyanaraman B. Recent Developments in the Probes and Assays for Measurement of the Activity of NADPH Oxidases. Cell Biochem Biophys. 2017 Dec;75(3-4):335-349. PMCID: PMC5693611

375. Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biol. 2017 Oct;13:94-162. PMCID: PMC5458069

376. Zielonka J, Joseph J, Sikora A, Hardy M, Ouari O, Vasquez-Vivar J, Cheng G, Lopez M, Kalyanaraman B. Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. Chem Rev. 2017 Aug 09;117(15):10043-10120. PMCID: PMC5611849

377. Kalyanaraman B. Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism. Redox Biol. 2017 Aug;12:833-842. PMCID: PMC5406543

378. Chandrashekaran V, Seth RK, Dattaroy D, Alhasson F, Ziolenka J, Carson J, Berger FG, Kalyanaraman B, Diehl AM, Chatterjee S. HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease. Redox Biol. 2017 Oct;13:8-19. PMCID: PMC5447385

379. Variar G, Pant T, Singh A, Ravichandran A, Swami S, Kalyanaraman B, Dhanasekaran A. Effect of mitochondrially targeted carboxy proxyl nitroxide on Akt-mediated survival in Daudi cells: Significance of a dual mode of action. PLoS One. 2017;12(4):e0174546. PMCID: PMC5398517

380. Kalyanaraman B, Cheng G, Hardy M, Ouari O, Sikora A, Zielonka J, Dwinell MB. Modified Metformin as a More Potent Anticancer Drug: Mitochondrial Inhibition, Redox Signaling, Antiproliferative Effects and Future EPR Studies. Cell Biochem Biophys. 2017 Dec;75(3-4):311-317. PMCID: PMC5680142

381. Kalyanaraman B, Cheng G, Hardy M, Ouari O, Sikora A, Zielonka J, Dwinell M. Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms. Interface Focus. 2017 Apr 06;7(2):20160109. PMCID: PMC5311906

382. Kalyanaraman B, Zielonka J. Green fluorescent proteins induce oxidative stress in cells: A worrisome new wrinkle in the application of the GFP reporter system to biological systems? Redox Biol. 2017 Aug;12:755-757. PMCID: PMC5397015

383. Langley M, Ghosh A, Charli A, Sarkar S, Ay M, Luo J, Zielonka J, Brenza T, Bennett B, Jin H, Ghaisas S, Schlichtmann B, Kim D, Anantharam V, Kanthasamy A, Narasimhan B, Kalyanaraman B, Kanthasamy AG. Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice. Antioxid Redox Signal. 2017 Nov 10;27(14):1048-1066. PMCID: PMC5651937

384. Kalyanaraman B, Cheng G, Hardy M, Ouari O, Lopez M, Joseph J, Zielonka J, Dwinell MB. A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds. Redox Biol. 2018 Apr;14:316-327. PMCID: PMC5633086

385. Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A. Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162]. Redox Biol. 2018 Apr;14:694-696. PMCID: PMC5975209

386. Xie LN, Huang CH, Xu D, Li F, Zhu JG, Shen C, Shao B, Gao HY, Kalyanaraman B, Zhu BZ. Unusual Double Beckmann Fragmentation Reaction under Physiological Conditions. J Org Chem. 2017 Dec 15;82(24):13084-13092.

387. Sarna T, Kalyanaraman B, Berliner L. Xth EPR Workshop on Applications of EPR in Biology and Medicine. Cell Biochem Biophys. 2017 Dec;75(3-4):257-258. PMCID: PMC5691121

388. Hardy M, Zielonka J, Karoui H, Sikora A, Michalski R, Podsiadły R, Lopez M, Vasquez-Vivar J, Kalyanaraman B, Ouari O. Detection and Characterization of Reactive Oxygen and Nitrogen Species in Biological Systems by Monitoring Species-Specific Products. Antioxid Redox Signal. 2018 May 20;28(15):1416-1432. PMCID: PMC5910052

389. Kalyanaraman B, Cheng G, Hardy M, Ouari O, Bennett B, Zielonka J. Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies. Redox Biol. 2018 May;15:347-362. PMCID: PMC5756055

390. Kalyanaraman B, Cheng G, Hardy M, Ouari O, Lopez M, Joseph J, Zielonka J, Dwinell MB. Corrigendum to 'A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds' [REDOX 14C (2017) 316-327]. Redox Biol. 2018 Jun;16:426-427. PMCID: PMC5952812

391. Zielonka J, Kalyanaraman B. Small-molecule luminescent probes for the detection of cellular oxidizing and nitrating species. Free Radic Biol Med. 2018 Nov 20;128:3-22. PMCID: PMC6146080

392. Cheng G, Zielonka M, Dranka B, Kumar SN, Myers CR, Bennett B, Garces AM, Dias Duarte Machado LG, Thiebaut D, Ouari O, Hardy M, Zielonka J, Kalyanaraman B. Detection of mitochondria-generated reactive oxygen species in cells using multiple probes and methods: Potentials, pitfalls, and the future. J Biol Chem. 2018 Jun 29;293(26):10363-10380. PMCID: PMC6028982

393. Xu Z, Ni B, Cao Z, Zielonka J, Gao J, Chen F, Kalyanaraman B, White GC, Ma YQ. Kindlin-3 negatively regulates the release of neutrophil extracellular traps. J Leukoc Biol. 2018 Sep;104(3):597-602. PMCID: PMC6113072

394. Boyle KA, Van Wickle J, Hill RB, Marchese A, Kalyanaraman B, Dwinell MB. Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation. J Biol Chem. 2018 Sep 21;293(38):14891-14904. PMCID: PMC6153299

395. Cheng G, Zhang Q, Pan J, Lee Y, Ouari O, Hardy M, Zielonka M, Myers CR, Zielonka J, Weh K, Chang AC, Chen G, Kresty L, Kalyanaraman B, You M. Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis. Nat Commun. 2019 May 17;10(1):2205. PMCID: PMC6525201

396. Xu D, Huang CH, Xie LN, Shao B, Mao L, Shao J, Kalyanaraman B, Zhu BZ. Mechanism of unprecedented hydroxyl radical production and site-specific oxidative DNA damage by photoactivation of the classic arylhydroxamic acid carcinogens. Carcinogenesis. 2019 Jan 08.

397. Pan J, Lee Y, Cheng G, Zielonka J, Zhang Q, Bajzikova M, Xiong D, Tsaih SW, Hardy M, Flister M, Olsen CM, Wang Y, Vang O, Neuzil J, Myers CR, Kalyanaraman B, You M. Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity. iScience. 2018 May 25;3:192-207. PMCID: PMC6137433

398. Kalyanaraman B, Cheng G, Zielonka J, Bennett B. Low-Temperature EPR Spectroscopy as a Probe-Free Technique for Monitoring Oxidants Formed in Tumor Cells and Tissues: Implications in Drug Resistance and OXPHOS-Targeted Therapies. Cell Biochem Biophys. 2019 Mar;77(1):89-98. PMCID: PMC6430651

399. Brenza TM, Schlichtmann BW, Bhargavan B, Vela Ramirez JE, Nelson RD, Panthani MG, McMillan JM, Kalyanaraman B, Gendelman HE, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B, Kanmogne GD. Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery. J Biomed Mater Res A. 2018 Nov;106(11):2881-2890. PMCID: PMC6366942

400. Xie LN, Shao J, Huang CH, Li F, Xu D, Kalyanaraman B, Zhu BZ. An unusual double radical homolysis mechanism for the unexpected activation of the aldoxime nerve-agent antidotes by polyhalogenated quinoid carcinogens under normal physiological conditions. Free Radic Biol Med. 2019 Jan;130:1-7.

401. Kalyanaraman B. Teaching the basics of the mechanism of doxorubicin-induced cardiotoxicity: Have we been barking up the wrong tree? Redox Biology. January 2020;29.

402. Cheng G, Pan J, Podsiadly R, Zielonka J, Garces AM, Dias Duarte Machado LG, Bennett B, McAllister D, Dwinell MB, You M, Kalyanaraman B. Increased formation of reactive oxygen species during tumor growth: Ex vivo low-temperature EPR and in vivo bioluminescence analyses. Free Radic Biol Med. 2020 Feb 01;147:167-174. PMCID: PMC6948008

403. Qin L, Huang CH, Xu D, Xie LN, Shao J, Mao L, Kalyanaraman B, Zhu BZ. Molecular mechanism for the activation of the anti-tuberculosis drug isoniazid by Mn(III): First detection and unequivocal identification of the critical N-centered isoniazidyl radical and its exact location. Free Radic Biol Med. 2019 Nov 01;143:232-239.

404. Zhu BZ, Xu D, Qin L, Huang CH, Xie LN, Mao L, Shao J, Kalyanaraman B. An unexpected new pathway for nitroxide radical production via more reactve nitrogen-centered amidyl radical intermediate during detoxification of the carcinogenic halogenated quinones by N-alkyl hydroxamic acids. Free Radic Biol Med. 2020 Jan;146:150-159.

405. Wright KD, Miller BS, El-Meanawy S, Tsaih SW, Banerjee A, Geurts AM, Sheinin Y, Sun Y, Kalyanaraman B, Rui H, Flister MJ, Sorokin A. The p52 isoform of SHC1 is a key driver of breast cancer initiation. Breast Cancer Res. 2019 Jun 15;21(1):74. PMCID: PMC6570928

406. Cheng G, Zielonka J, Hardy M, Ouari O, Chitambar CR, Dwinell MB, Kalyanaraman B. Synergistic inhibition of tumor cell proliferation by metformin and mito-metformin in the presence of iron chelators. Oncotarget. 2019 May 28;10(37):3518-3532. PMCID: PMC6544408

407. Besson E, Gastaldi S, Bloch E, Zielonka J, Zielonka M, Kalyanaraman B, Aslan S, Karoui H, Rockenbauer A, Ouari O, Hardy M. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals. Analyst. 2019 Jul 21;144(14):4194-4203.

408. Zielonka J, Zielonka M, Cheng G, Hardy M, Kalyanaraman B. High-Throughput Screening of NOX Inhibitors. Methods Mol Biol. 2019;1982:429-446. PMCID: PMC6953630

409. Zielonka J, Zielonka M, Kalyanaraman B. HPLC-Based Monitoring of Oxidation of Hydroethidine for the Detection of NADPH Oxidase-Derived Superoxide Radical Anion. Methods Mol Biol. 2019;1982:243-258. PMCID: PMC6953631

410. Berliner L, Raguz M, Kalyanaraman B, Sarna T. Introduction to the Second Adriatic Symposium on Biophysical Approaches in Biomedical Studies Cell Biochemistry and Biophysics. 15 March 2019;77(1).

411. Hogg N, Zielonka J, Kalyanaraman B. Detection of Nitric Oxide and Peroxynitrite in Biological Systems: A State-of-the-Art Review Nitric Oxide: Biology and Pathobiology: Third Edition. 1 January 2017:23-44.

412. Valez V, Cassina A, Batinic-Haberle I, Kalyanaraman B, Ferrer-Sueta G, Radi R. Erratum: Peroxynitrite formation in nitric oxide-exposed submitochondrial particles: Detection, oxidative damage and catalytic removal by Mn-porphyrins (Archives of Biochemistry and Biophysics (2013) 529 (45-54)) Archives of Biochemistry and Biophysics. 1 April 2014;547:44.

413. Zielonka J, Sikora A, Joseph J, Kalyanaraman B. Reply to Jourd'heuil: Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide Journal of Biological Chemistry. 27 August 2010;285(35).

414. Kalyanaraman B. Teaching the basics of the mechanism of doxorubicin-induced cardiotoxicity: Have we been barking up the wrong tree? Redox Biol. 2020 Jan;29:101394. PMCID: PMC6909145

415. Chowdhury AR, Zielonka J, Kalyanaraman B, Hartley RC, Murphy MP, Avadhani NG. Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon. Redox Biol. 2020 Sep;36:101606. PMCID: PMC7327929

416. Shao J, Huang CH, Shao B, Qin L, Xu D, Li F, Qu N, Xie LN, Kalyanaraman B, Zhu BZ. Potent Oxidation of DNA by Haloquinoid Disinfection Byproducts to the More Mutagenic Imidazolone dIz via an Unprecedented Haloquinone-Enoxy Radical-Mediated Mechanism. Environ Sci Technol. 2020 May 19;54(10):6244-6253.

417. Zhang Q, Cheng G, Pan J, Zielonka J, Xiong D, Myers CR, Feng L, Shin SS, Kim YH, Bui D, Hu M, Bennett B, Schmainda K, Wang Y, Kalyanaraman B, You M. Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I. Cell Commun Signal. 2020 Apr 07;18(1):58. PMCID: PMC7140380

418. Xu D, Huang CH, Qin L, Xie LN, Mao L, Shao J, Kalyanaraman B, Zhu BZ. Corrigendum to "An unexpected new pathway for nitroxide radical production via more reactve nitrogen-centered amidyl radical intermediate during detoxification of the carcinogenic halogenated quinones by N-alkyl hydroxamic acids" [Free Radic. Biol. Med. 146 (2020) 150-159/FRBM_2019_405]. Free Radic Biol Med. 2020 May 20;152:869.

419. Rios N, Radi R, Kalyanaraman B, Zielonka J. Tracking isotopically labeled oxidants using boronate-based redox probes. J Biol Chem. 2020 May 08;295(19):6665-6676. PMCID: PMC7212653

420. Berliner L, Sarna T, Kalyanaraman B. XIth EPR Workshop on Applications of EPR in Biology and Medicine Cell Biochemistry and Biophysics. 2020.

421. Kalyanaraman B, Konorev EA, Joseph J, Baker JE. Radical generation and detection in myocardial injury New Comprehensive Biochemistry. 1 January 1994;28(C):333-359.

422. Schreiber J, Mottley C, Sinha BK, Kalyanaraman B, Mason RP. One-Electron Reduction of Daunomycin, Daunomycinone, and 7-Deoxydaunomycinone by the Xanthine/Xanthine Oxidase System: Detection of Semiquinone Free Radicals by Electron Spin Resonance Journal of the American Chemical Society. 1 January 1987;109(2):348-351.

423. Mottley C, Kalyanaraman B, Mason RP. Spin trapping artifacts due to the reduction of nitroso spin traps FEBS Letters. 20 July 1981;130(1):12-14.

424. Chignell CF, Kalyanaraman B, Sik RH, Mason RP. SPECTROSCOPIC STUDIES OF CUTANEOUS PHOTOSENSITIZING AGENTS—II. SPIN TRAPPING OF PHOTOLYSIS PRODUCTS FROM SULFANILAMIDE AND 4‐AMINOBENZOIC ACID USING 5,5‐DIMETHYL‐1‐PYRROLINE‐1‐OXIDE Photochemistry and Photobiology. August 1981;34(2):147-156.

425. Chignell CF, Kalyanaraman B, Mason RP, Sik RH. SPECTROSCOPIC STUDIES OF CUTANEOUS PHOTOSENSITIZING AGENTS—I. SPIN TRAPPING OF PHOTOLYSIS PRODUCTS FROM SULFANILAMIDE, 4‐AMINOBENZOIC ACID AND RELATED COMPOUNDS Photochemistry and Photobiology. November 1980;32(5):563-571.

426. Kalyanaraman B, Perez-Reyes E, Mason RP. The reduction of nitroso-spin traps in chemical and biological sysetms. A cautionary note Tetrahedron Letters. 1979;20(50):4809-4812.

427. Kent Kirk T, Tien M, Kersten PJ, Kalyanaraman B, Hammel KE, Farrell RL. Lignin peroxidase from fungi: Phanerochaete chrysosporium Methods in Enzymology. 1 January 1990;188(C):159-171.

428. Kalyanaraman B. Do free radical NETwork and oxidative stress disparities in African Americans enhance their vulnerability to SARS-CoV-2 infection and COVID-19 severity? Redox Biol. 2020 Oct;37:101721. PMCID: PMC7490257

429. Kalyanaraman B. Teaching the basics of repurposing mitochondria-targeted drugs: From Parkinson's disease to cancer and back to Parkinson's disease. Redox Biol. 2020 Sep;36:101665. PMCID: PMC7426584

430. Angireddy R, Chowdhury AR, Zielonka J, Ruthel G, Kalyanaraman B, Avadhani NG. Alcohol-induced CYP2E1, mitochondrial dynamics and retrograde signaling in human hepatic 3D organoids. Free Radic Biol Med. 2020 Nov 01;159:1-14.

431. Berliner L, Sarna T, Kalyanaraman B. XIth EPR Workshop on Applications of EPR in Biology and Medicine. Cell Biochem Biophys. 2020 Jun;78(2):121-122.

432. Michalski R, Thiebaut D, Michałowski B, Ayhan MM, Hardy M, Ouari O, Rostkowski M, Smulik-Izydorczyk R, Artelska A, Marcinek A, Zielonka J, Kalyanaraman B, Sikora A. Oxidation of ethidium-based probes by biological radicals: mechanism, kinetics and implications for the detection of superoxide. Sci Rep. 2020 Oct 29;10(1):18626. PMCID: PMC7596101

433. Sikora A, Zielonka J, Dębowska K, Michalski R, Smulik-Izydorczyk R, Pięta J, Podsiadły R, Artelska A, Pierzchała K, Kalyanaraman B. Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology. Front Chem. 2020;8:580899. PMCID: PMC7545953

434. Cheng G, Hardy M, Topchyan P, Zander R, Volberding P, Cui W, Kalyanaraman B. Potent inhibition of tumour cell proliferation and immunoregulatory function by mitochondria-targeted atovaquone. Sci Rep. 2020 Oct 21;10(1):17872. PMCID: PMC7578061

435. Cheng G, Hardy M, Zielonka J, Weh K, Zielonka M, Boyle KA, Abu Eid M, McAllister D, Bennett B, Kresty LA, Dwinell MB, Kalyanaraman B. Mitochondria-targeted magnolol inhibits OXPHOS, proliferation, and tumor growth via modulation of energetics and autophagy in melanoma cells. Cancer Treat Res Commun. 2020;25:100210. PMCID: PMC7883397

436. Kotamraju S, Williams CL, Kalyanaraman B. Erratum: Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways (Cancer Research (2007) 67, (7386-7394)) Cancer Research. 15 September 2007;67(18):8973.

437. Brown SA, Zaharova S, Mason P, Thompson J, Thapa B, Ishizawar D, Wilkes E, Ahmed G, Rubenstein J, Sanchez J, Joyce D, Kalyanaraman B, Widlansky M. Pandemic Perspective: Commonalities Between COVID-19 and Cardio-Oncology. Front Cardiovasc Med. 2020;7:568720. PMCID: PMC7746643

438. Zielonka J, Sikora A, Podsiadly R, Hardy M, Kalyanaraman B. Identification of Peroxynitrite by Profiling Oxidation and Nitration Products from Mitochondria-Targeted Arylboronic Acid. Methods Mol Biol. 2021;2275:315-327. PMCID: PMC9245525

439. Siarkiewicz P, Michalski R, Sikora A, Smulik-Izydorczyk R, Szala M, Grzelakowska A, Modrzejewska J, Bailey A, Nycz JE, Kalyanaraman B, Malecki JG, Zielonka J, Podsiadły R. On the chemical reactivity of tricyanofuran(TCF)-based near-infrared fluorescent redox probes – Effects of glutathione on the probe response and product fluorescence Dyes and Pigments. August 2021;192.

440. Cheng G, Hardy M, Topchyan P, Zander R, Volberding P, Cui W, Kalyanaraman B. Mitochondria-targeted hydroxyurea inhibits OXPHOS and induces antiproliferative and immunomodulatory effects. iScience. 2021 Jun 25;24(6):102673. PMCID: PMC8215227

441. AbuEid M, McAllister DM, McOlash L, Harwig MC, Cheng G, Drouillard D, Boyle KA, Hardy M, Zielonka J, Johnson BD, Hill RB, Kalyanaraman B, Dwinell MB. Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression. iScience. 2021 Jun 25;24(6):102653. PMCID: PMC8220235

442. Schlichtmann BW, Kalyanaraman B, Schlichtmann RL, Panthani MG, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B. Functionalized polyanhydride nanoparticles for improved treatment of mitochondrial dysfunction Journal of Biomedical Materials Research - Part B Applied Biomaterials. 2021.

443. Chelimsky G, Simpson P, Zhang L, Bierer D, Komas S, Kalyanaraman B, Chelimsky T. Impaired Mitochondrial Bioenergetics Function in Pediatric Chronic Overlapping Pain Conditions with Functional Gastrointestinal Disorders. Pain Res Manag. 2021;2021:6627864. PMCID: PMC8380178

444. Schlichtmann BW, Kalyanaraman B, Schlichtmann RL, Panthani MG, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B. Functionalized polyanhydride nanoparticles for improved treatment of mitochondrial dysfunction. J Biomed Mater Res B Appl Biomater. 2022 Feb;110(2):450-459.

445. Berliner L, Raguz M, Kalyanaraman B, Sarna T. Introduction to the Second Adriatic Symposium on Biophysical Approaches in Biomedical Studies Cell Biochemistry and Biophysics. 15 March 2019;77(1).

446. Kalyanaraman B. Reactive oxygen species, proinflammatory and immunosuppressive mediators induced in COVID-19: overlapping biology with cancer. RSC Chem Biol. 2021 Oct 07;2(5):1402-1414. PMCID: PMC8496060

447. Berliner L, Raguz M, Kalyanaraman B, Sarna T. Introduction to the Second Adriatic Symposium on Biophysical Approaches in Biomedical Studies Cell Biochemistry and Biophysics. 15 March 2019;77(1).

448. Huang M, Xiong D, Pan J, Zhang Q, Wang Y, Myers CR, Johnson BD, Hardy M, Kalyanaraman B, You M. Prevention of Tumor Growth and Dissemination by In Situ Vaccination with Mitochondria-Targeted Atovaquone. Adv Sci (Weinh). 2022 Apr;9(12):e2101267. PMCID: PMC9036031

449. Cheng G, Hardy M, You M, Kalyanaraman B. Combining PEGylated mito-atovaquone with MCT and Krebs cycle redox inhibitors as a potential strategy to abrogate tumor cell proliferation. Sci Rep. 2022 Mar 24;12(1):5143. PMCID: PMC8948292

450. Kalyanaraman B. Exploiting the tumor immune microenvironment and immunometabolism using mitochondria-targeted drugs: Challenges and opportunities in racial disparity and cancer outcome research. FASEB J. 2022 Apr;36(4):e22226. PMCID: PMC9242412

451. Berliner L, Raguz M, Kalyanaraman B, Sarna T. Introduction to the Second Adriatic Symposium on Biophysical Approaches in Biomedical Studies Cell Biochemistry and Biophysics. 15 March 2019;77(1).

452. Berliner L, Raguz M, Kalyanaraman B, Sarna T. Introduction to the Second Adriatic Symposium on Biophysical Approaches in Biomedical Studies Cell Biochemistry and Biophysics. 15 March 2019;77(1).

453. Michalski R, Smulik-Izydorczyk R, Pięta J, Rola M, Artelska A, Pierzchała K, Zielonka J, Kalyanaraman B, Sikora AB. The Chemistry of HNO: Mechanisms and Reaction Kinetics. Front Chem. 2022;10:930657. PMCID: PMC9294461

454. Kalyanaraman B, Cheng G, Hardy M. Therapeutic Targeting of Tumor Cells and Tumor Immune Microenvironment Vulnerabilities. Front Oncol. 2022;12:816504. PMCID: PMC9214210

455. Murphy MP, Bayir H, Belousov V, Chang CJ, Davies KJA, Davies MJ, Dick TP, Finkel T, Forman HJ, Janssen-Heininger Y, Gems D, Kagan VE, Kalyanaraman B, Larsson NG, Milne GL, Nyström T, Poulsen HE, Radi R, Van Remmen H, Schumacker PT, Thornalley PJ, Toyokuni S, Winterbourn CC, Yin H, Halliwell B. Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo. Nat Metab. 2022 Jun;4(6):651-662. PMCID: PMC9711940

456. Zhang Q, Xiong D, Pan J, Wang Y, Hardy M, Kalyanaraman B, You M. Chemoprevention of Lung Cancer with a Combination of Mitochondria-Targeted Compounds. Cancers (Basel). 2022 May 21;14(10). PMCID: PMC9140024

457. Cheng G, Hardy M, Kalyanaraman B. Antiproliferative effects of mitochondria-targeted N-acetylcysteine and analogs in cancer cells. Sci Rep. 2023 May 04;13(1):7254. PMCID: PMC10160116

458. Cheng G, Karoui H, Hardy M, Kalyanaraman B. Polyphenolic Boronates Inhibit Tumor Cell Proliferation: Potential Mitigators of Oxidants in the Tumor Microenvironment. Cancers (Basel). 2023 Feb 08;15(4). PMCID: PMC9953882

459. Kalyanaraman B. NAC, NAC, Knockin' on Heaven's door: Interpreting the mechanism of action of N-acetylcysteine in tumor and immune cells. Redox Biol. 2022 Nov;57:102497. PMCID: PMC9563555

460. Kalyanaraman B, Cheng G, Hardy M, You M. OXPHOS-targeting drugs in oncology: new perspectives. Expert Opin Ther Targets. 2023;27(10):939-952.

461. Cheng G, Karoui H, Hardy M, Kalyanaraman B. Redox-crippled MitoQ potently inhibits breast cancer and glioma cell proliferation: A negative control for verifying the antioxidant mechanism of MitoQ in cancer and other oxidative pathologies. Free Radic Biol Med. 2023 Aug 20;205:175-187.

462. Berliner L, Raguz M, Kalyanaraman B, Sarna T. Introduction to the Second Adriatic Symposium on Biophysical Approaches in Biomedical Studies Cell Biochemistry and Biophysics. 15 March 2019;77(1).

1. KALYANARAMAN, B.: Detection of toxic free radicals in biology and medicine. In: Reviews in Biochemical Toxicology, Vol. IV. (E. Hodgson, J.R. Bend and R.M. Philpot, eds.) Elsevier, 1982, pp. 73-139.

2. Mason, R. P., Harrelson, W. G., KALYANARAMAN, B., Mottley, C., Peterson, F. J., and Holtzman, J. L. Free radical metabolites of chemical carcinogens. In: Free Radicals, Lipid Peroxidation and Cancer (D. C. H. McBrien and T. F. Slater, eds.) Academic Press, New York, 1982, pp. 377-95.

3. KALYANARAMAN, B. and Sivarajah, K.: The ESR study of free radicals formed during the arachidonic acid cascade and co-oxidation of xenobiotics by prostaglandin synthetase. In: Free Radicals in Biology, Vol. VI. (W.A. Pryor, ed.) Academic Press, New York, 1984, pp. 149-98.

4. KALYANARAMAN, B., Felix, C. C., and Sealy, R. C.: Semiquinone anion radicals of catechol(amine)s, catechol estrogens, and their metal ion complexes. Environ. Health Perspect. 64, 185-98 (1985).

5. Antholine, W. E., KALYANARAMAN, B., and Petering, D. H.: ESR of copper and iron complexes with antitumor and cytotoxic properties. Environ. Health Perspect. 64, 19-35 (1985).

6. KALYANARAMAN, B. and Sinha, B. K.: Free radical-mediated activation of hydra-zine deriv¬atives. Environ. Health Perspect. 64, 179-84 (1985).

7. KALYANARAMAN, B., Hintz, P., and Sealy, R. C.: An electron spin resonance study of free radicals from catechol estrogens. Fed. Proc. 45, 2477-84 (1986). Review.

8. Hammel, K. E., KALYANARAMAN, B., and Kirk, T. K.: Oxidation of aromatic pollutants by P. chrysosporium ligninase. In: Lignin: Enzymic and Microbial Degradation (E. Odier, ed.) Institut National de la Recherch Agronomique, Paris, 1987, pp. 45-9.

9. Kersten, P. J., KALYANARAMAN, B., Hammel, K. E., and Kirk, T. K.: Horseradish peroxidase oxidizes 1,2,4,5 aetramethoxybenzene by a cation radical mechanism. In: Lignin: Enzymic and Microbial Degradation (E. Odier, ed.) Institut National de la Recherch Agronomique, Paris, 1987, pp. 75-9.

10. Odlier, E., Mozuch, K., KALYANARAMAN, B., and Kirk, T. K.: Cellobiose quinone oxidoreductase does not prevent oxidative coupling of phenols or polymerization of lignin by ligninase. In: Lignin: Enzymic and Microbial Degradation (E. Odier, ed.) Institut National de la Recherch Agronomique, Paris, 1987, pp. 131-6.

11. KALYANARAMAN, B.: Free radicals from catecholamine hormones, neuromelanins and neurotoxins. In: Handbook of Antioxidants and Free Radicals in Medicine, CRC Press, Boca Raton, FL, 1989.

12. Hodnick, W. F., KALYANARAMAN, B., and Pardini, R. S.: The production of hydroxyl and semiquinone radicals during the autoxidation of redox active flavonoids. In: Oxygen Radicals in Biology and Medicine (M.G. Simic, J.F. Ward, and K.A. Taylor, eds.) Plenum, New York, 1988, pp. 149-52.

13. Baker, J. E., Felix, C. C., and KALYANARAMAN, B.: Detection of free radicals by direct ESR during myocardial cell injury - a critical evaluation. In: Oxy-Radicals in Molecular Biology and Pathology (P. Cerutti, I. Fridovich, and J. McCord, eds.) Alan R. Liss, New York, 1988, pp. 343-51.

14. Baker, J., Felix, C. C., Olinger, G. N., and KALYANARAMAN, B.: ESR spectroscopy provides direct evidence for free radical generation during myocardial ischemia and reperfusion. In: Free Radicals, Methodology and Concepts (C. Rice-Evans and B. Halliwell, eds.) Richelieu, London, 1988, pp. 185-99.

15. KALYANARAMAN, B.: Characterization of o-semiquinone radicals in biological systems. Methods Enzymol. 186, 333-43 (1990).

16. KALYANARAMAN, B. and Feix, J. B.: The use of spin label oximetry in photody-namic studies. Spectrum 3, 9 (1990).

17. KALYANARAMAN, B., Antholine, W. E., Joseph, J., and Parthasarathy, S.: An ESR study of the oxidative modification of low density lipoproteins. In: Oxidative Damage and Repair: Chemical, Biochemical, and Medical Aspects (K. J. A. Davies, ed.) Pergamon Press, New York, 1991, pp. 154-9.

18. KALYANARAMAN, B., Darley-Usmar, V. M., and Parthasarathy, S.: Synergistic reaction betweeen probucol-derived radical and ascorbic acid during oxidation of low-density lipoprotein. In: Active Oxygens, Lipid Peroxides, and Antioxidants (K. Yaki, ed.) Japan Science Society Press, Tokyo, 1993, pp. 111-5.

19. Darley-Usmar, V. M., Hersey, A., Gotoh, N., Niki, E., Hogg, N., KALYANARAMAN, B., Stone, D., and Wilson, M. T.: Lipid peroxidation in human low-density lipoprotein: interactions between antioxidants, transition metals, and lipid hydroperoxides. In: Antioxidants, Free Radicals, and Polyunsaturated Fatty Acids in Biology and Medicine (A. T. Diplock, J. M. C. Gutteridge, and V. K. S. Shukla, eds.) International Food Science Centre, 1993, pp. 49-55.

20. KALYANARAMAN, B., Konorev, E. A., Joseph, J., and Baker, J. E.: Radical generation and detection in myocardial reperfusion injury. In: Physical Methods in Biochemistry (C. Rice-Evans, ed.) Richelieu, London, 1993.

21. KALYANARAMAN, B.: Free radical mechanism of oxidative modification of low-density lipoprotein. In: Oxidative Stress and Antioxidant Defenses in Biology (S. Ahmed, ed.) Chapman & Hall, 1994.

22. Darley-Usmar, V. M., Mason, R. P., Chamulitrat, W., Hogg, N., and KALYANARAMAN, B.: Lipid peroxidation and cardiovascular disease. In: Immunopharmacology of Free Radical Species (P. Winyard, ed.) Academic Press, New York, 1995, pp. 23-37.

23. KALYANARAMAN, B.: Thiyl radicals in biological systems: significant or trivial? Biochem. Soc. Symp. 61, 55-63, 1995. Review.

24. Favier, A. E., Cadet, J., KALYANARAMAN, B., Fontecave M., and Pierre, J. L. (eds.): Analysis of Free Radicals in Biological Systems. Birkhäuser Verlag, Boston, 1995.

25. KALYANARAMAN, B.: Detection of nitric oxide by electron spin resonance in chemical, photo¬chemical, cellular, physiological, and pathophysiological systems. In: Nitric Oxide, Part A - Sources (L. Packer, ed.) [Methods Enzymol. 268] (1996), pp. 168-87.

26. Thomas C. and KALYANARAMAN, B. (eds.): Oxygen Radicals in Diseases. Gordon Publishers, U.K., 1997.

27. Darley-Usmar, V. M., Hogg, N., KALYANARAMAN, B., and Moore, K.: Free radicals in the vasculature. In: Oxidative Stress, Lipoproteins, and Cardiovascular Dysfunction (Portand Press Research Monograph 7) (C. Rice-Evans and K.R. Bruckdorfer, eds.), Portland Press, pp. 81-98, 1995.

28. Darley-Usmar, V. M., Moncada, S., Hogg, N., and KALYANARAMAN, B.: Lipid hydroperoxides and atherosclerosis. In: International Congress Series (T. Yoshikawa, ed.) Excerpta Medica, International Congress series 1058, Elsevier Science, pp. 509-12, 1994.

29. Hogg, N. and KALYANARAMAN, B. The use of nitric oxide gas in biological systems, in: Methods in Molecular Biology, Vol. 100. Nitric Oxide Protocols (M. A. Titheradge, ed.), Totowa, NJ: Humana Press, pp. 233-8, 1997.

30. V´asquez-Vivar, J.,Martsek, P., Hogg, N., Karoui, H., Masters, B. S. S., Pritchard, K. A. Jr., and KALYANARAMAN, B.: Electron spin resonance spin-trapping detection of superoxide generated by neuronal nitric oxide synthase. In: Nitric Oxide, Part C: Biological and Antioxidant Activities (L. Packer, ed.) [Methods Enzymol. 301] (1999), pp. 169-77. Review.

31. Goss, S. P. A., KALYANARAMAN, B., and Hogg, N.: Antioxidant effects of nitric oxide and nitric oxide donor compounds on low-density lipoprotein. In: Nitric Oxide, Part C: Biological and Antioxidant Activities (L. Packer, ed.) [Methods Enzymol. 301: 444-53, 1998. Review.]

32. KALYANARAMAN, B., Joseph, J., Kalivendi, S., Wang, S., Konorev, E., Kotamraju, S.: Doxorubicin-induced apoptosis: implications in cardiotoxicity. In: Microcompetition with Foreign DNA and the Origin of Chronic Disease. [Mol. Cell. Biochem. 234-235 (1-2):119-24, 2002. Review.]

33. Kotamraju, S., Kalivendi, S.V., Konorev, E., Chitambar, C.R, Joseph, J., KALYANARAMAN, B. Oxidant-induced iron signaling in doxorubicin-mediated apoptosis. Methods Enzymol. 378:362-82, 2004. Review.

34. KALYANARAMAN, B. Introduction to the Review series "Protein Radicals in Biological Systems - ESR Spin Trapping and Immuno Spin Trapping Approaches". Free Radic. Biol. Med. 36:1071, 2004.

35. KALYANARAMAN, B. Introduction to the Review Series on redox-active metal ions, reactive oxygen species and apoptosis. Free Radic. Biol. Med. 37:573, 2004.

36. Vásquez-Vivar, J., Martásek, P., KALYANARAMAN, B. Superoxide generation from nitric oxide synthase. Role of cofactors and protein-protein interaction. Biological Magnetic Resonance, Volume 23, Biomedical EPR - Part A: Free Radicals, Metals, Medicine, and Physiology, (S. S. Eaton, G. R. Eaton, and L. J. Berliner, eds.), Kluwer Academic/Plenum Publishers, New York, 75-91 (2005).

37. Zhang, H., Joseph, J., KALYANARAMAN, B. Hydrophobic tyrosyl probes for monitoring nitration reactions in membranes. Methods Enzymol. 396:182-204, 2005.

38. Kotamraju, S., Kalivendi, S., Shang, T., KALYANARAMAN, B. Nitric oxide, proteasomal function, and iron homeostasis - implications in aging and neurodegenerative diseases. Methods Enzymol. 396:526-34, 2005.

39. KALYANARAMAN, B. Iron signaling and oxidant damage. Cardiovasc.Toxicol. 7:92-4, 2007. Review.

40. Zhang, H., Xu, Y., Joseph, J., KALYANARAMAN, B. Influence of intramolecular electron transfer mechanism in biological nitration, nitrosation, and oxidation of redox-sensitive amino acids. Methods Enzymol. 440:65-94, 2008. Review.

41. Bartesaghi, S., Peluffo, G., Zhang, H., Joseph, J., KALYANARAMAN, B., Radi, R. Tyrosine nitration, dimerization, and hydroxylation by peroxynitrite in membranes as studied by the hydrophobic probe N-t-BOC-1-tyrosine tert-butyl ester. Methods Enzymol. 441C:217-36, 2008.

42. Zielonka, J., KALYANARAMAN, B. "ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis" - A critical commentary. Free Radic. Biol. Med. 45:1217-9, 2008. [PMCID: 3595710]

43. Janssen-Heininger, Y.M., Mossman, B.T., Heintz, N.H., Forman, H.J., KALYANARAMAN, B., Finkel, T., Stamler, J.S., Rhee, S.G., van der Vliet, A. Redox-based regulation of signal transduction: principles, pitfalls, and promises. Free Radic. Biol. Med. 45:1-17, 2008. Review. [PMCID: PMC2453533]

44. Subramanian, S., KALYANARAMAN, B., Migrino, R.Q. Mitochondrially targeted antioxidants for the treatment of cardiovascular diseases. Recent Pat. Cardiovasc. Drug Discov. 5:54-65, 2010. Review.

45. Zielonka, J., KALYANARAMAN, B. Hydroethidine- and Mito-SOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: Another inconvenient truth. Free Radic. Biol. Med. 48:983-1001, 2010. Review. [PMCID: PMC35871542]

46. KALYANARAMAN, B. Oxidative chemistry of fluorescent dyes: Implications in the detection of reactive oxygen and nitrogen species. Biochem. Soc. Trans. 39:1221-5, 2011. Review. PMID: 21936793

47. Zielonka, J., KALYANARAMAN, B. Methods of investigation of selected radical oxygen/nitrogen species in cell-free and cellular systems. In: Principles of Free Radical Biomedicine, Volume 1, K. Pantopoulos and H.M. Schipper (eds). Nova Science Publishers, 2011.

48. Zielonka, J., Joseph, J., Sikora, A., KALYANARAMAN, B. Real-time monitoring of reactive oxygen and nitrogen species in a multiwell plate using the diagnostic marker products of specific probes. Methods Enzymol. 526:145-57, 2013. PMID: 23791099

49. Debowska, K., Debski, D., Hardy, M., Jakubowska, M., KALYANARAMAN, B., Marcinek, A., Michalski, R., Michalowski, B., Ouari, O., Sikora, A., Smulik, R., Zielonka, J. Toward selective detection of reactive oxygen and nitrogen species with the use of fluorogenic probes - Limitations, progress, and perspectives. Pharmacol. Rep. 67(4):756-64, 2015. Review. PMID: 26321278

50. KALYANARAMAN, B., Hardy, M., Zielonka, J. A critical review of methodologies to detect reactive oxygen and nitrogen species by NADPH oxidase enzymes: implications in pesticide toxicity. Curr. Pharmacol. Rep. (in press, 2016). [NIHMS: 792899]

1. Zielonka, J., Sikora, A., Joseph, J., KALYANARAMAN, B. Reply to Jourd'heuil: Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide. J. Biol. Chem. 285:le16, 2010. [PMCID: PMC2930751]

1. KALYANARAMAN, B. (2007), "Chemistry and biochemistry of molecular probes used in the detection of reactive oxygen and nitrogen species", in Davies, K. (ed.), Free Radicals and the Oxygen Paradox: Oxidative Stress in Biology, Aging and Disease, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd., London (online at http://hstalks.com/bio and http://hstalks.com/lib.php?t=HST28.1682_1_2&c=252)

1. U.S. Patent No. 6,589,751 (issued July 8, 2003), “Immunological detection of the homocystamide adduct and a thiolactone immunoassay for endogeneous homocysteine” Inventors: Eric Ferguson, Sampath Parthasarathy, and Balaraman Kalyanaraman

2. U.S. Patent No. 7,223,864 (issued May 29, 2007), “2-hydroxyethidium, methods of preparation and uses thereof” Inventors: Balaraman Kalyanaraman and Hongtao Zhao

3. U.S. Patent No. 8,143,420 (issued March 27, 2012), “Bifunctional and trifunctional nitrone spin trapping compounds and uses thereof” Inventors: Micael Hardy, Neil Hogg, Balaraman Kalyanaraman, Marcos Lopez, Olivier Ouari, and Paul Tordo

4. U.S. Patent No. 8, 388,931 (issued March 5, 2013) “99mTc-labeled triphenylphosphonium derivative contrasting agents and molecular probes for early detection and imaging of breast tumors” Inventors: Balaraman Kalyanaraman, Micael Hardy, Marcos Lopez, and Ming Zhao

5. U.S. Patent No. 8,388,936 (issued March 5, 2013), “In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging” Inventors: Balaraman Kalyanaraman, Joy Joseph, Kathleen Schmainda, Douglas Prah, Marcos Lopez, and Micael Hardy

6. U.S. Patent No. 8,466,130 (issued June 18, 2013) “Mitochondria targeted cationic anti-oxidant compounds for prevention, therapy or treatment of hyper-proliferative disease, neoplasias and cancers” Inventors: David A. Zarling, Hirak S. Basu, Balaraman Kalyanaraman, and Joy Joseph

7. U.S. Patent No. 8,962,600 (issued February 24, 2015), “Neuroprotective compounds and their use” Inventors: Balaraman Kalyanaraman, Joy Joseph, and Anumantha Kanthasamy