CURRICULUM VITAE
Benjamin N. Gantner PhD
Benjamin N. Gantner PhD
Assistant Professor
Department of Medicine
Division of Endocrinology
Department of Medicine
Division of Endocrinology
OFFICE ADDRESS: |
Health Research Center |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
Phone: 414-955-4755 |
Email: bgantner@mcw.edu |
EDUCATION: |
- 1997 BA, University of Illinois at Urbana-Champaign, Department of Anthropology, Champaign-Urbana, IL |
- 2004 PhD, University of Washington at Seattle, Department of Immunology, Seattle, WA |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
01/2005 - 09/2007 Postdoctoral Fellow, Howard Hughes Medical Institute, University of Chicago, Chicago, IL |
09/2007 - 08/2012 Postdoctoral Fellow, Department of Pharmacology, University of Illinois at Chicago, Chicago, IL |
FACULTY APPOINTMENTS: |
08/2012 - 10/2016 Research Assistant Professor, Department of Pharmacology, University of Illinois at Chicago, Chicago, IL |
10/2016 - 08/2018 Senior Research Scientist, Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL |
09/2018 - Present Assistant Professor, Department of Medicine, Division of Endocrinology, The Medical College of Wisconsin, Milwaukee, WI |
05/2021 - Present Assistant Professor (Secondary Appointment), Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI |
AWARDS AND HONORS: |
09/2002 - 10/2004 National Cancer Institute Trainee, Basic and Cancer Immunology, University of Washington at Seattle |
09/2005 - 09/2007 Postdoctoral Training Fellowship (NRSA), Committee on Immunology, University of Chicago |
09/2007 - 09/2008 Postdoctoral Training Fellowship (NRSA), Department of Pharmacology, University of Illinois Chicago |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
02/2021 - Present Society for Redox Biology & Medicine (Member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Journal Review |
Blood |
Scientific Reports |
FASEB journal |
Infection and Immunity |
Oncogene |
Nitric Oxide |
Endocrinology |
Circulation |
Atherosclerosis, Thrombosis, and Vascular Biology |
PLOS One |
LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2021 - Present Reviewer, Office of Research PPG Formation Committee, Advancing a Healthier Wisconsin Endowment Research and Education Program (AHW REP) |
2021 - Present Reviewer, We Care Scientific Review Committee, Department of Surgery, MCW |
03/01/2023 - Present Vice Chair, Institutional Biosafety Commitee, Medical College of Wisconsin |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
10/01/2021 - Present Reviewer, Molecular Signaling (Basic Science 9) Fellowship, American Heart Association |
10/01/2022 - Present Reviewer, Career Development Award / Basic Sciences #1 Review Committee, American Heart Association |
11/01/2023 - Present Reviewer, Small Business Activities Special Emphasis Panel (Respiratory Sciences) ZRG1 CVRS B_11, 2023/11, National Institute of Health |
05/01/2024 - Present Reviewer, Special Emphasis Panel (Development of the Fetal Immune System) ZRG1 EMS-A (57), 2024/05, National Institute of Health |
08/06/2024 - Present Reviewer, Reviewer, Special Emphasis Panel (Member Conflict: Respiratory Sciences) ZRG1 RCCS-M (03), National Institute of Health |
09/09/2024 - Present Reviewer, Reviewer, Special Emphasis Panel (Member Conflict: Respiratory Sciences) ZRG1 RCCS-M (05), National Institute of Health |
10/01/2024 - Present Reviewer, Transformational Project Award, Basic Sciences, American Heart Association |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
National |
Gantner, BN, Dectin-1 promotes TLR2 mediated inflammatory cytokine transcription, Invited Workshop Talk at Keystone Symposium, Innate Immunity: Evolution and Link to Adaptive Immunity, Taos, NM, 02/15/2002 |
Gantner, BN, Intravital Imaging Reveals Novel Inflammatory Programming by Macrophages, Invited Lecture at Wayne State University Integrative Biosciences Center, Detroit. MI, 06/14/2017 |
Regional |
Gantner, BN, Intravital Imaging In Moving Organs, Invited Lecture at Chicago Biomedical Consortium Advanced Imaging Symposium, Northwestern University, Chicago, IL, 02/04/2016 |
Local |
Gantner, BN, Intravital Imaging Reveals Novel Inflammatory Programming by Macrophages, Invited Lecture at Department of Pathology, University of Illinois Chicago, Chicago, IL, 04/20/2017 |
Gantner, BN, Intravital Imaging Reveals Novel Inflammatory Programming by Macrophages, Invited Lecture at Department of Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, 02/14/2018 |
Gantner-BN, Watching the Watchers: Intravital Imaging to Study Pulmonary Neutrophils, Center for Immunology Retreat, Milwaukee, WI, 10/18/2018 - Present |
Gantner-BN, Physiology Seminar Series, Milwaukee, WI, 12/12/2018 - Present |
Gantner-BN, Watching the Watchers: Intravital Imaging
to Study Neutrophil Polarization, MCW Center for Immunology WIP, Milwaukee, WI, 01/04/2019 - Present |
Gantner-BN, Reprogramming Neutrophils to Control Tissue Injury, Cancer Center Retreat, Milwaukee, WI, 04/26/2019 - Present |
Gantner-BN, Inflammatory Programming of Innate Immune Cells: In Vitro and In Vivo, MCW CVC Research in Progress Series, Milwaukee, WI, 12/11/2019 - Present |
Inflammatory Programming of Innate Immune Cells: In Vivo and In Vitro, Department of Biochemistry Seminary Series, Medical College of Wisconsin, Milwaukee, WI, 05/20/2020 - Present |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
01/2019 - Present Committee Member, MCW Cardiovascular Center Space and Equipment Committee, MCW Cardiovascular Center, Medical College of Wisconsin |
02/2020 - 01/2023 Committee Member, Institutional Biosafety Committee, MCW/Froedtert/Versiti/Children's |
01/2022 - Present Committee Member, MCW Cancer Center Space Committee, Medical College of Wisconsin Cancer Center |
MCW TEACHING ACTIVITIES: |
Medical Student Education |
2020 - 2022 Molecules to Cells (M1), Preceptor for group discussions (2x1.5hr) |
Graduate Student Education |
01/2024 Foundations in Biomedical Sciences IV - Innate Immunity and Inflammation |
11/2024 Foundations in Biomedical Sciences II - Mitochondria |
Postdoctoral Fellow Education |
10/2021 - Present Current Concepts in Cardiovascular Biology (PHYS08270) - Leukocyte Trafficking |
EXTRAMURAL TEACHING: |
Graduate Student Education |
03/2018 University of Illinois at Chicago, Introduction to Immunity in Integrative Biology (Lecturer for GEMS510) |
04/2018 University of Illinois at Chicago, Immune evasion in Microbial Pathogenesis (Lecturer for MIM560) |
Community/Lay Public |
08/1999 - 12/1999 University of Washington at Seattle, Introduction to Immunology |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Graduate Students |
PhD Committees |
11/01/2019 - 01/23/2023 Olivia Koehn, Investigating regulation of small GTPase prenylation
and localization by SmgGDS and unique isoformspecific differences of RAC1 and RAC1B, Medical College of Wisconsin |
2019 - 2020 Rachel Schlaak, Identifying Genetic Modifiers of Radiation-Induced Cardiac Dysfunction Using Pre-Clinical Models, Medical College of Wisconsin |
07/01/2020 - Present Alyssa Fernandez, Medical College of Wisconsin |
2020 - Present Gage Stuttgen, Medical College of Wisconsin |
2020 - 2022 Jose Rosas, IL-12 Promotes Secondary Damage and Locomotor Impairment in Spinal Cord Injury, Medical College of Wisconsin |
2021 - Present Raymundo Nunez, Medical College of Wisconsin |
2022 - Present Alex Kowalczyk, TBD, Medical College of Wisconsin |
2022 - Present Christopher Hansen, Medical College of Wisconsin |
2023 - Present Leonard Asare, TBD, Medical College of Wisconsin |
2023 - Present Paul Sidlowski, TBD, Medical College of Wisconsin |
2024 - Present Elisabeth Solis, TBD, Medical College of Wisconsin |
2024 - Present Huda Zayed, TBD, Medical College of Wisconsin |
PhD Students Advised |
2021 - Present Katy LaFond, Medical College of Wisconsin |
Postdoctoral Researchers |
01/01/2019 - 06/01/2023 Diego Coelho, Co-mentor, Medical College of Wisconsin, Coelho DR, Palma FR, Paviani V, LaFond KM, Huang Y, Wang D, Wray B, Rao S, Yue F, Bonini MG, Gantner BN. SOCS1 regulates a subset of NFκB-target genes through direct chromatin binding and defines macrophage functional phenotypes. iScience. 2023 Apr 21;26(4):106442. PMCID: PMC10068561 |
06/01/2019 - 06/01/2022 Veronica Paviani, Co-mentor, Medical College of Wisconsin |
11/01/2019 - 09/17/2021 German Fonseca Cabrera, Advisor, Medical College of Wisconsin |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Coelho DR, Palma FR, Paviani V, LaFond KM, Huang Y, Wang D, Wray B, Rao S, Yue F, Bonini MG, Gantner BN. SOCS1 regulates a subset of NFκB-target genes through direct chromatin binding and defines macrophage functional phenotypes. iScience. 2023 Apr 21;26(4):106442. PMCID: PMC10068561 |
2. Puzyrenko A, Jacobs ER, Padilla N, Devine A, Aljadah M, Gantner BN, Pan AY, Lai S, Dai Q, Rubenstein JC, North PE, Simpson PM, Willoughby RE, O'Meara CC, Flinn MA, Lough JW, Ibrahim EH, Zheng Z, Sun Y, Felix J, Hunt BC, Ross G, Rui H, Benjamin IJ. Collagen-Specific HSP47<sup>+</sup> Myofibroblasts and CD163<sup>+</sup> Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS-CoV-2 Infections. J Am Heart Assoc. 2023 Feb 21;12(4):e027990. PMCID: PMC10111490 |
3. Xu H, Thomas MJ, Kaul S, Kallinger R, Ouweneel AB, Maruko E, Oussaada SM, Jongejan A, Cense HA, Nieuwdorp M, Serlie MJ, Goldberg IJ, Civelek M, Parks BW, Lusis AJ, Knaack D, Schill RL, May SC, Reho JJ, Grobe JL, Gantner B, Sahoo D, Sorci-Thomas MG. Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake. Arterioscler Thromb Vasc Biol. 2021 Nov;41(11):2708-2725. PMCID: PMC8551036 |
4. Puzyrenko A, Jacobs ER, Sun Y, Felix JC, Sheinin Y, Ge L, Lai S, Dai Q, Gantner BN, Nanchal R, North PE, Simpson PM, Rui H, Benjamin IJ. Pneumocytes are distinguished by highly elevated expression of the ER stress biomarker GRP78, a co-receptor for SARS-CoV-2, in COVID-19 autopsies. Cell Stress Chaperones. 2021 Sep;26(5):859-868. PMCID: PMC8357488 |
5. Danes JM, de Abreu ALP, Kerketta R, Huang Y, Palma FR, Gantner BN, Mathison AJ, Urrutia RA, Bonini MG. Inorganic arsenic promotes luminal to basal transition and metastasis of breast cancer. FASEB J. 2020 Dec;34(12):16034-16048. PMCID: PMC8289339 |
6. Schlaak RA, Frei A, Fish BL, Harmann L, Gasperetti T, Pipke JL, Sun Y, Rui H, Flister MJ, Gantner BN, Bergom C. Acquired Immunity Is Not Essential for Radiation-Induced Heart Dysfunction but Exerts a Complex Impact on Injury. Cancers (Basel). 2020 Apr 16;12(4). PMCID: PMC7226421 |
7. He C, Danes JM, Hart PC, Zhu Y, Huang Y, de Abreu AL, O'Brien J, Mathison AJ, Tang B, Frasor JM, Wakefield LM, Ganini D, Stauder E, Zielonka J, Gantner BN, Urrutia RA, Gius D, Bonini MG. SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23534-23541. PMCID: PMC6876149 |
8. Baig MS, Zaichick SV, Mao M, de Abreu AL, Bakhshi F, Hart PC, Sarqib U, Deng J, Chatterjee S, Block M, Vogel S, Malik A, Consolaro M, Christman JW, Minshall RD, **Gantner BN, **Bonini MG. NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1. J Exp Med. Sep 21;212(10):1725-1738. 2015. PMCID: PMC4577833,
**Corresponding author |
9. Chaudhuri S, Gantner BN, Ye RD, Cianciotto NP, Freitag NE. The Listeria monocytogenes ChiA chitinase enhances virulence through suppression of host innate immunity. MBio. 4:e00617-12, 2013. PMCID: PMC3604766. |
10. Sieracki NA, Gantner BN, Mao M, Horner JH, Ye RD, Malik AB, Newcomb ME, Bonini MG. Bioluminescent detection of peroxynitrite with a boronic acid-caged luciferin. Free Radical Biology & Medicine. 61C:40-50, 2013. PMCID: PMC3795912 |
11. Gantner BN, Jin H, Qian F, Hay N, He B, Ye RD. The Akt1 isoform is required for optimal IFN-beta transcription through direct phosphorylation of beta-catenin. Journal of Immunology. 189(6):3104-11, 2012. PMCID: PMC3658160. |
12. Qian F, Deng J, Gantner BN, Flavell RA, Dong C, Christman JW, Ye RD. Map kinase phosphatase 5 protects against sepsis-induced acute lung injury. American Journal of Physiology-Lung Cellular and Molecular Physiology. 302(9):L866-74, 2012. PMCID: PMC3362165. |
13. Laslo P, Spooner CJ, Warmflash A, Lancki DW, Lee HJ, Sciammas R, Gantner BN, Dinner AR, Singh H. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell. 126(4):755-66, 2006. PMID: 1692339 |
14. Gantner BN, Simmons RM, Underhill DM. Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. EMBO Journal 24(6):1277-86, 2005. PMCID: PMC556398. |
15. Gantner BN, Simmons RM, Canavera SJ, Akira S, Underhill DM. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. Journal of Experimental Medicine. 197(9):1107-17, 2003. PMCID: PMC2193968. |
16. Norment AM, Bogatzki LY, Gantner BN, Bevan MJ. Murine CCR9, a chemokine receptor for thymus-expressed chemokine that is up-regulated following pre-TCR signaling. Journal of Immunology. Jan 15;164(2):639-648. 2000. PMID: 10623805. |
Books, Chapters, and Reviews |
1. Gantner BN**, LaFond KM, Bonini MG. Nitric oxide in cellular adaptation and disease Redox Biology. July 2020;34.
** Corresponding author |
2. Palma FR, He C, Danes JM, Paviani V, Coelho DR, Gantner BN, Bonini MG. Mitochondrial Superoxide Dismutase: What the Established, the Intriguing, and the Novel Reveal About a Key Cellular Redox Switch. Antioxid Redox Signal. 2020 Apr 01;32(10):701-714. PMCID: PMC7047081 |
3. Bonini MG, Gantner BN. The multifaceted activities of AMPK in tumor progression--why the "one size fits all" definition does not fit at all? IUBMB Life. 2013 Nov;65(11):889-96. |
4. Gantner BN, Singh H. Immunology: Short-term memory. Nature. 2007 Jun 21;447(7147):916-7. |
5. Underhill DM, Gantner B. Integration of Toll-like receptor and phagocytic signaling for tailored immunity. Microbes Infect. 2004 Dec;6(15):1368-73. |
6. Palma FR, Gantner BN, Sakiyama MJ, Kayzuka C, Shukla S, Lacchini R, Cunniff B, Bonini MG. ROS production by mitochondria: function or dysfunction? Oncogene. 2024 Jan;43(5):295-303. |
7. Palma FR, Coelho DR, Pulakanti K, Sakiyama MJ, Huang Y, Ogata FT, Danes JM, Meyer A, Furdui CM, Spitz DR, Gomes AP, Gantner BN, Rao S, Backman V, Bonini MG. Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance. Cell Rep. 2024 Mar 26;43(3):113897. PMCID: PMC11209755 |
8. Gantner BN, Palma FR, Kayzuka C, Lacchini R, Foltz DR, Backman V, Kelleher N, Shilatifard A, Bonini MG. Histone oxidation as a new mechanism of metabolic control over gene expression. Trends Genet. 2024 Sep;40(9):739-746. PMCID: PMC11387142 |
9. Palma FR, Coelho DR, Pulakanti K, Sakiyama MJ, Huang Y, Ogata FT, Danes JM, Meyer A, Furdui CM, Spitz DR, Gomes AP, Gantner BN, Rao S, Backman V, Bonini MG. Erratum: Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance (Cell Reports (2024) 43(3), (S2211124724002250), (10.1016/j.celrep.2024.113897)) Cell Reports. 23 July 2024;43(7). |
10. Kim J, Hong SK, Yang Y, Lee A, Hoffmeister KM, Gantner BN, Park JI. Prolonged warm ischemia time increases mitogen-activated protein kinase activity and decreases perfusate cytokine levels in <i>ex vivo</i> rat liver machine perfusion. Front Transplant. 2023;2:1215182. PMCID: PMC11235240 |
11. Palma FR, Coelho DR, Pulakanti K, Sakiyama MJ, Huang Y, Ogata FT, Danes JM, Meyer A, Furdui CM, Spitz DR, Gomes AP, Gantner BN, Rao S, Backman V, Bonini MG. Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance. Cell Rep. 2024 Jul 23;43(7):114415. PMCID: PMC11560056 |
