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CURRICULUM VITAE

Benjamin N. Gantner PhD
Assistant Professor
Department of Medicine
Division of Endocrinology

OFFICE ADDRESS:
Health Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226
Phone: 414-955-4755
Email: bgantner@mcw.edu

EDUCATION:
- 1997 BA, University of Illinois at Urbana-Champaign, Department of Anthropology, Champaign-Urbana, IL
- 2004 PhD, University of Washington at Seattle, Department of Immunology, Seattle, WA

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
01/2005 - 09/2007 Postdoctoral Fellow, Howard Hughes Medical Institute, University of Chicago, Chicago, IL
09/2007 - 08/2012 Postdoctoral Fellow, Department of Pharmacology, University of Illinois at Chicago, Chicago, IL

FACULTY APPOINTMENTS:
08/2012 - 10/2016 Research Assistant Professor, Department of Pharmacology, University of Illinois at Chicago, Chicago, IL
10/2016 - 08/2018 Senior Research Scientist, Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL
09/2018 - Present Assistant Professor, Department of Medicine, Division of Endocrinology, The Medical College of Wisconsin, Milwaukee, WI

AWARDS AND HONORS:
09/2002 - 10/2004 National Cancer Institute Trainee, Basic and Cancer Immunology, University of Washington at Seattle
09/2005 - 09/2007 Postdoctoral Training Fellowship (NRSA), Committee on Immunology, University of Chicago
09/2007 - 09/2008 Postdoctoral Training Fellowship (NRSA), Department of Pharmacology, University of Illinois Chicago

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Journal Review
PLOS One
Blood
Infection and Immunity
FASEB journal
Scientific Reports

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Macrophage Redox State in Sterilizing
Source:
NIH / NIAID
Role:
Co-Investigator
PI:
Marcelo Bonini, PhD
Dates:
04/07/2017 - 03/31/2022
Direct Funds:
$1,379,000 (total for all years)
 
Title:
WBCS Metabolic regulation of immunity in the tumor microenvironment
Source:
Wisconsin Breast Cancer Showhouse
Role:
Co-investigator
PI:
Marcelo Bonini
Dates:
06/01/2019 - 05/31/2021
Direct Funds:
$100,000
 
Title:
Discriminating Inflammatory and Physical Injury
Source:
MCW - Research Affairs Committee
Role:
PI
PI:
Benjamin Gantner
Dates:
07/01/2019 - 06/31/2021
Direct Funds:
$25,000
 
Non-Peer Review
Title:
Recruitment / Startup
Source:
AHW Research and Education Program
Role:
Principal Investigator
Dates:
09/01/2018 - 08/31/2021
Direct Funds:
$750,000 (total for all years)
 
Pending
Peer Review
Title:
Pathogen clearance and inflammatory tissue injury are separable aspects of bacterial pneumonia
Source:
NIAID
Role:
Multi-PI
PI:
Gantner, Benjamin(MPI) Bonini, Marcelo(MPI)
Dates:
04/01/2021 - 03/31/2026
Direct Funds:
$1,680,000
 
Title:
Nuclear reactive oxygen species, transcriptional plasticity and the emergence of dysfunctional cellular phenotypes in aging and cancer
Source:
NIH
Role:
Subsite PI/Co-Investigator
PI:
Bonini, Marcelo
Dates:
09/01/2021 - 08/31/2026
Direct Funds:
$862,123
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
Gantner, BN, Intravital Imaging Reveals Novel Inflammatory Programming by Macrophages, Invited Lecture at Department of Pathology, University of Illinois Chicago, Chicago, IL, 04/20/2017
Gantner, BN, Intravital Imaging Reveals Novel Inflammatory Programming by Macrophages, Invited Lecture at Department of Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, 02/14/2018
Gantner-BN, Watching the Watchers: Intravital Imaging to Study Pulmonary Neutrophils, Center for Immunology Retreat, Milwaukee, WI, 10/18/2018 - Present
Gantner-BN, Physiology Seminar Series, Milwaukee, WI, 12/12/2018 - Present
Gantner-BN, Watching the Watchers: Intravital Imaging to Study Neutrophil Polarization, MCW Center for Immunology WIP, Milwaukee, WI, 01/04/2019 - Present
Gantner-BN, Reprogramming Neutrophils to Control Tissue Injury, Cancer Center Retreat, Milwaukee, WI, 04/26/2019 - Present
Gantner-BN, Inflammatory Programming of Innate Immune Cells: In Vitro and In Vivo, MCW CVC Research in Progress Series, Milwaukee, WI, 12/11/2019 - Present
Inflammatory Programming of Innate Immune Cells: In Vivo and In Vitro, Department of Biochemistry Seminary Series, Medical College of Wisconsin, Milwaukee, WI, 05/20/2020 - Present
 
Regional
Gantner, BN, Intravital Imaging In Moving Organs, Invited Lecture at Chicago Biomedical Consortium Advanced Imaging Symposium, Northwestern University, Chicago, IL, 02/04/2016
 
National
Gantner, BN, Dectin-1 promotes TLR2 mediated inflammatory cytokine transcription, Invited Workshop Talk at Keystone Symposium, Innate Immunity: Evolution and Link to Adaptive Immunity, Taos, NM, 02/15/2002
Gantner, BN, Intravital Imaging Reveals Novel Inflammatory Programming by Macrophages, Invited Lecture at Wayne State University Integrative Biosciences Center, Detroit. MI, 06/14/2017
 

COMMITTEE SERVICE:
Medical College of Wisconsin
01/01/2019 - Present Faculty Advisor, Space and Equipment, Cardiovascular Center, Medical College of Wisconsin
02/01/2020 - 01/31/2023 Faculty Biosafety Advisor, Institutional Biosafety Committee
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Medical Student Education
09/2020 - Present Molecules to Cells (M1), Preceptor for group discussions (2x1.5hr)
 

EXTRAMURAL TEACHING:
Community/Lay Public
08/1999 - 12/1999 University of Washington at Seattle, Introduction to Immunology
 
Graduate Student Education
03/2018 University of Illinois at Chicago, Introduction to Immunity in Integrative Biology (Lecturer for GEMS510)
04/2018 University of Illinois at Chicago, Immune evasion in Microbial Pathogenesis (Lecturer for MIM560)
 

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Graduate Students
PhD Committees
Rachel Schlaak, Medical College of Wisconsin, 02/01/2019 - 07/13/2020 Identifying Genetic Modifiers of Radiation-Induced Cardiac Dysfunction Using Pre-Clinical Models
Olivia Koehn, Medical College of Wisconsin, 11/01/2019 - Present
Alyssa Fernandez, Medical College of Wisconsin, 07/01/2020 - Present
Gage Stuttgen, Medical College of Wisconsin, 07/01/2020 - Present
Jose Rosas, Medical College of Wisconsin, 09/01/2020 - Present
 
Postdoctoral Students
Diego Coelho, Medical College of Wisconsin, 01/01/2019 - Present Co-mentor
Veronica Paviani, Medical College of Wisconsin, 06/01/2019 - Present Co-mentor
German Fonseca Cabrera, Medical College of Wisconsin, 11/01/2019 - Present Advisor
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Schlaak RA, Frei A, Fish BL, Harmann L, Gasperetti T, Pipke JL, Sun Y, Rui H, Flister MJ, Gantner BN, Bergom C. Acquired Immunity Is Not Essential for Radiation-Induced Heart Dysfunction but Exerts a Complex Impact on Injury. Cancers (Basel). 2020 Apr 16;12(4). PMCID: PMC7226421
2. He C, Danes JM, Hart PC, Zhu Y, Huang Y, de Abreu AL, O'Brien J, Mathison AJ, Tang B, Frasor JM, Wakefield LM, Ganini D, Stauder E, Zielonka J, Gantner BN, Urrutia RA, Gius D, Bonini MG. SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer. Proc Natl Acad Sci U S A. 2019 11 19;116(47):23534-23541. PMCID: PMC6876149
3. Baig MS, Zaichick SV, Mao M, de Abreu AL, Bakhshi F, Hart PC, Sarqib U, Deng J, Chatterjee S, Block M, Vogel S, Malik A, Consolaro M, Christman JW, Minshall RD, **Gantner BN, **Bonini MG. NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1. J Exp Med. Sep 21;212(10):1725-1738. 2015. PMCID: PMC4577833, **Corresponding author
4. Chaudhuri S, Gantner BN, Ye RD, Cianciotto NP, Freitag NE. The Listeria monocytogenes ChiA chitinase enhances virulence through suppression of host innate immunity. MBio. 4:e00617-12, 2013. PMCID: PMC3604766.
5. Sieracki NA, Gantner BN, Mao M, Horner JH, Ye RD, Malik AB, Newcomb ME, Bonini MG. Bioluminescent detection of peroxynitrite with a boronic acid-caged luciferin. Free Radical Biology & Medicine. 61C:40-50, 2013. PMCID: PMC3795912
6. Gantner BN, Jin H, Qian F, Hay N, He B, Ye RD. The Akt1 isoform is required for optimal IFN-beta transcription through direct phosphorylation of beta-catenin. Journal of Immunology. 189(6):3104-11, 2012. PMCID: PMC3658160.
7. Qian F, Deng J, Gantner BN, Flavell RA, Dong C, Christman JW, Ye RD. Map kinase phosphatase 5 protects against sepsis-induced acute lung injury. American Journal of Physiology-Lung Cellular and Molecular Physiology. 302(9):L866-74, 2012. PMCID: PMC3362165.
8. Laslo P, Spooner CJ, Warmflash A, Lancki DW, Lee HJ, Sciammas R, Gantner BN, Dinner AR, Singh H. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell. 126(4):755-66, 2006. PMID: 1692339
9. Gantner BN, Simmons RM, Underhill DM. Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. EMBO Journal 24(6):1277-86, 2005. PMCID: PMC556398.
10. Gantner BN, Simmons RM, Canavera SJ, Akira S, Underhill DM. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. Journal of Experimental Medicine. 197(9):1107-17, 2003. PMCID: PMC2193968.
11. Norment AM, Bogatzki LY, Gantner BN, Bevan MJ. Murine CCR9, a chemokine receptor for thymus-expressed chemokine that is up-regulated following pre-TCR signaling. Journal of Immunology. Jan 15;164(2):639-648. 2000. PMID: 10623805.
 
Books, Chapters, and Reviews
1. Gantner BN**, LaFond KM, Bonini MG. Nitric oxide in cellular adaptation and disease Redox Biology. July 2020;34. ** Corresponding author
2. Palma FR, He C, Danes JM, Paviani V, Coelho DR, Gantner BN, Bonini MG. Mitochondrial Superoxide Dismutase: What the Established, the Intriguing, and the Novel Reveal About a Key Cellular Redox Switch. Antioxid Redox Signal. 2020 04 01;32(10):701-714. PMCID: PMC7047081
3. Bonini MG, Gantner BN. The multifaceted activities of AMPK in tumor progression--why the "one size fits all" definition does not fit at all? IUBMB Life. 2013 Nov;65(11):889-96.
4. Gantner BN, Singh H. Immunology: Short-term memory. Nature. 2007 Jun 21;447(7147):916-7.
5. Underhill DM, Gantner B. Integration of Toll-like receptor and phagocytic signaling for tailored immunity. Microbes Infect. 2004 Dec;6(15):1368-73.
 

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