CURRICULUM VITAE
Dawn M. Wenzel PhD
Dawn M. Wenzel PhD
Assistant Professor
Department of Biochemistry
Department of Biochemistry
OFFICE ADDRESS: |
Basic Science Building |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
Phone: 414-955-4346 |
Email: dwenzel@mcw.edu |
EDUCATION: |
2000 - 2004 B.S., University of Wisconsin, Madison, WI |
2004 - 2010 PhD, University of Washington, Seattle, WA |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
2011 - 2020 Postdoctoral Fellow, Biochemistry, University of Utah School of Medicine, University of Utah, Salt Lake City, UT 84112 |
FACULTY APPOINTMENTS: |
10/01/2020 - Present Assistant Professor, Biochemistry, The Medical College of Wisconsin, Milwaukee, WI 53226 |
AWARDS AND HONORS: |
- 2010 Schultz Travel Fellowship, University of Washington Department of Biochemistry |
- 2017 Postdoctoral Travel Award, University of Utah Graduate School |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||
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COMMUNITY SERVICE ACTIVITIES: |
2014 - 2018 Salt Lake Valley Science and Engineering Fair judge years: 2014, 2015, 2017, 2018 |
- 09/2015 ASBMB 50 state challenge. |
- 03/2009 Seattle Expanding Your Horizons (SEYH) day. Co-designed and taught a science lab about salivary amalayse to middle school girls. |
- 04/2010 'PAWS on Science' Exhibitor at the Seattle Pacific Science Center. Hands on activity demonstrating protein folding for the general public. |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Wenzel DM, Lissounov A, Brzovic PS, Klevit RE. UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids. Nature. 2011 Jun 02;474(7349):105-8. PMCID: PMC3444301 |
2. Skalicky JJ, Arii J, Wenzel DM, Stubblefield WM, Katsuyama A, Uter NT, Bajorek M, Myszka DG, Sundquist WI. Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport. J Biol Chem. 2012 Dec 21;287(52):43910-26. PMCID: PMC3527974 |
3. Vittal V, Wenzel DM, Brzovic PS, Klevit RE. Biochemical and structural characterization of the ubiquitin-conjugating enzyme UBE2W reveals the formation of a noncovalent homodimer. Cell Biochem Biophys. 2013 Sep;67(1):103-10. PMCID: PMC3758794 |
4. Vittal V, Shi L, Wenzel DM, Scaglione KM, Duncan ED, Basrur V, Elenitoba-Johnson KS, Baker D, Paulson HL, Brzovic PS, Klevit RE. Intrinsic disorder drives N-terminal ubiquitination by Ube2w. Nat Chem Biol. 2015 Jan;11(1):83-9. PMCID: PMC4270946 |
5. Caballe A, Wenzel DM, Agromayor M, Alam SL, Skalicky JJ, Kloc M, Carlton JG, Labrador L, Sundquist WI, Martin-Serrano J. ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins. Elife. 2015 May 26;4:e06547. PMCID: PMC4475061 |
6. Sadler JBA, Wenzel DM, Strohacker LK, Guindo-MartÃnez M, Alam SL, Mercader JM, Torrents D, Ullman KS, Sundquist WI, Martin-Serrano J. A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8900-E8908. PMCID: PMC6156662 |
Books, Chapters, and Reviews |
1. Wenzel DM, Stoll KE, Klevit RE. E2s: structurally economical and functionally replete. Biochem J. 2011 Jan 01;433(1):31-42. PMCID: PMC3118098 |
2. Wenzel DM, Klevit RE. Following Ariadne's thread: a new perspective on RBR ubiquitin ligases. BMC Biol. 2012 Mar 15;10:24. PMCID: PMC3305615 |
3. Wenzel DM, Stoll KE, Klevit RE. E2s: Structurally economical and functionally replete Biochemical Journal. 1 February 2011;433(3):535. |
Non-Refereed Journal Publications/Original Papers |
1. Talledge N, McCullough J, Wenzel DM, Nguyen HC, Lalonde MS, Bajorek M, Skalicky JS, Frost A, Sundquist WI. The ESCRT-III proteins CHMP1B and IST1 assemble around nucleic acids. bioRxiv 386532; doi:https://doi.org/10.1101/386532 |