Medical College of Wisconsin
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CURRICULUM VITAE

Eckehard A. Stuth MD
Professor
Department of Anesthesiology
Division of Pediatric Anesthesiology

OFFICE ADDRESS:
Children’s Wisconsin - Milwaukee Hospital
8915 W Connell Court
Milwaukee, WI 53226


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Stuth EA, Tonkovic-Capin M, Kampine JP, Zuperku EJ. Dose-dependent effects of isoflurane on the CO2 responses of expiratory medullary neurons and the phrenic nerve activities in dogs. Anesthesiology. 1992 May;76(5):763-74.
2. Stuth EA, Tonkovic-Capin M, Kampine JP, Bajic J, Zuperku EJ. Dose-dependent effects of halothane on the carbon dioxide responses of expiratory and inspiratory bulbospinal neurons and the phrenic nerve activities in dogs. Anesthesiology. 1994 Dec;81(6):1470-83.
3. McCrimmon DR, Zuperku EJ, Hayashi F, Dogas Z, Hinrichsen CF, Stuth EA, Tonkovic-Capin M, Krolo M, Hopp FA. Modulation of the synaptic drive to respiratory premotor and motor neurons. Respir Physiol. 1997 Nov;110(2-3):161-76.
4. Frommelt PC, Stuth EA. Transesophageal echocardiographic in total anomalous pulmonary venous drainage: hypotension caused by compression of the pulmonary venous confluence during probe passage. J Am Soc Echocardiogr. 1994;7(6):652-4.
5. Dogas Z, Stuth EA, Hopp FA, McCrimmon DR, Zuperku EJ. NMDA receptor-mediated transmission of carotid body chemoreceptor input to expiratory bulbospinal neurones in dogs. J Physiol. 1995 Sep 15;487 ( Pt 3)(Pt 3):639-51. PMCID: PMC1156651
6. Stuth EA, Dogas Z, Krolo M, Kampine JP, Hopp FA, Zuperku EJ. Dose-dependent effects of halothane on the phrenic nerve responses to acute hypoxia in vagotomized dogs. Anesthesiology. 1997 Dec;87(6):1428-39.
7. Stuth EA, Dogas Z, Krolo M, Kampine JP, Hopp FA, Zuperku EJ. Effects of halothane on the phrenic nerve responses to carbon dioxide mediated by carotid body chemoreceptors in vagotomized dogs. Anesthesiology. 1997 Dec;87(6):1440-9.
8. Tonkovic-Capin M, Krolo M, Stuth EA, Hopp FA, Zuperku EJ. Improved method of canine decerebration. J Appl Physiol (1985). 1998 Aug;85(2):747-50.
9. Dogas Z, Krolo M, Stuth EA, Tonkovic-Capin M, Hopp FA, McCrimmon DR, Zuperku EJ. Differential effects of GABAA receptor antagonists in the control of respiratory neuronal discharge patterns. J Neurophysiol. 1998 Nov;80(5):2368-77.
10. Krolo M, Stuth EA, Tonkovic-Capin M, Dogas Z, Hopp FA, McCrimmon DR, Zuperku EJ. Differential roles of ionotropic glutamate receptors in canine medullary inspiratory neurons of the ventral respiratory group. J Neurophysiol. 1999 Jul;82(1):60-8.
11. Stuth EA, Krolo M, Tonkovic-Capin M, Hopp FA, Kampine JP, Zuperku EJ. Effects of halothane on synaptic neurotransmission to medullary expiratory neurons in the ventral respiratory group of dogs. Anesthesiology. 1999 Sep;91(3):804-14.
12. Stuth EA, Stucke AG, Berens RJ. Negative-pressure pulmonary edema in a child with hiccups during induction. Anesthesiology. 2000 Jul;93(1):282-4.
13. Krolo M, Stuth EA, Tonkovic-Capin M, Hopp FA, McCrimmon DR, Zuperku EJ. Relative magnitude of tonic and phasic synaptic excitation of medullary inspiratory neurons in dogs. Am J Physiol Regul Integr Comp Physiol. 2000 Aug;279(2):R639-49.
14. Tonkovic-Capin M, Zuperku EJ, Stuth EA, Bajic J, Dogas Z, Hopp FA. Effect of central CO(2) drive on lung inflation responses of expiratory bulbospinal neurons in dogs. Am J Physiol Regul Integr Comp Physiol. 2000 Nov;279(5):R1606-18.
15. Stuth EA, Krolo M, Stucke AG, Tonkovic-Capin M, Tonkovic-Capin V, Hopp FA, Kampine JP, Zuperku EJ. Effects of halothane on excitatory neurotransmission to medullary expiratory neurons in a decerebrate dog model. Anesthesiology. 2000 Dec;93(6):1474-81.
16. Stucke AG, Stuth EA, Tonkovic-Capin V, Tonkovic-Capin M, Hopp FA, Kampine JP, Zuperku EJ. Effects of sevoflurane on excitatory neurotransmission to medullary expiratory neurons and on phrenic nerve activity in a decerebrate dog model. Anesthesiology. 2001 Aug;95(2):485-91.
17. Stuth EA, Stucke AG, Cohen RD, Jaquiss RD, Kugathasan S, Litwin SB. Successful resuscitation of a child after exsanguination due to aortoesophageal fistula from undiagnosed foreign body. Anesthesiology. 2001 Oct;95(4):1025-6.
18. Stucke AG, Stuth EA. Use of rapacuronium in a child with spinal muscular atrophy. Paediatr Anaesth. 2001 Nov;11(6):725-8.
19. Tonkovic-Capin V, Stucke AG, Stuth EA, Tonkovic-Capin M, Krolo M, Hopp FA, McCrimmon DR, Zuperku EJ. Differential modulation of respiratory neuronal discharge patterns by GABA(A) receptor and apamin-sensitive K(+) channel antagonism. J Neurophysiol. 2001 Nov;86(5):2363-73.
20. Stucke AG, Stuth EA, Tonkovic-Capin V, Tonkovic-Capin M, Hopp FA, Kampine JP, Zuperku EJ. Effects of halothane and sevoflurane on inhibitory neurotransmission to medullary expiratory neurons in a decerebrate dog model. Anesthesiology. 2002 Apr;96(4):955-62.
21. Tonkovic-Capin V, Stucke AG, Stuth EA, Tonkovic-Capin M, Hopp FA, McCrimmon DR, Zuperku EJ. Differential processing of excitation by GABAergic gain modulation in canine caudal ventral respiratory group neurons. J Neurophysiol. 2003 Feb;89(2):862-70.
22. Stucke AG, Zuperku EJ, Tonkovic-Capin V, Tonkovic-Capin M, Hopp FA, Kampine JP, Stuth EA. Halothane depresses glutamatergic neurotransmission to brain stem inspiratory premotor neurons in a decerebrate dog model. Anesthesiology. 2003 Apr;98(4):897-905.
23. Stuth EA, Stucke AG, Fedderly RT, Tweddell JS. Complete staged palliation of hypoplastic left heart syndrome in a child with cystic fibrosis. Paediatr Anaesth. 2003 May;13(4):345-8.
24. Stucke AG, Zuperku EJ, Tonkovic-Capin V, Krolo M, Hopp FA, Kampine JP, Stuth EA. Halothane enhances gamma-aminobutyric acid receptor type A function but does not change overall inhibition in inspiratory premotor neurons in a decerebrate dog model. Anesthesiology. 2003 Dec;99(6):1303-12.
25. Hoffman GM, Stuth EA, Jaquiss RD, Vanderwal PL, Staudt SR, Troshynski TJ, Ghanayem NS, Tweddell JS. Changes in cerebral and somatic oxygenation during stage 1 palliation of hypoplastic left heart syndrome using continuous regional cerebral perfusion. J Thorac Cardiovasc Surg. 2004 Jan;127(1):223-33.
26. Hoffman GM, Tweddell JS, Ghanayem NS, Mussatto KA, Stuth EA, Jaquis RD, Berger S. Alteration of the critical arteriovenous oxygen saturation relationship by sustained afterload reduction after the Norwood procedure. J Thorac Cardiovasc Surg. 2004 Mar;127(3):738-45.
27. Walker SG, Stuth EA. Single-ventricle physiology: perioperative implications. Semin Pediatr Surg. 2004 Aug;13(3):188-202.
28. Stuth EA, Stucke AG, Cava JR, Hoffman GM, Berens RJ. Droperidol for perioperative sedation causes a transient prolongation of the QTc time in children under volatile anesthesia. Paediatr Anaesth. 2004 Oct;14(10):831-7.
29. Krolo M, Tonkovic-Capin V, Stucke AG, Stuth EA, Hopp FA, Dean C, Zuperku EJ. Subtype composition and responses of respiratory neurons in the pre-botzinger region to pulmonary afferent inputs in dogs. J Neurophysiol. 2005 May;93(5):2674-87.
30. Stucke AG, Zuperku EJ, Tonkovic-Capin V, Krolo M, Hopp FA, Kampine JP, Stuth EA. Sevoflurane depresses glutamatergic neurotransmission to brainstem inspiratory premotor neurons but not postsynaptic receptor function in a decerebrate dog model. Anesthesiology. 2005 Jul;103(1):50-6.
31. Stucke AG, Zuperku EJ, Krolo M, Brandes IF, Hopp FA, Kampine JP, Stuth EA. Sevoflurane enhances gamma-aminobutyric acid type A receptor function and overall inhibition of inspiratory premotor neurons in a decerebrate dog model. Anesthesiology. 2005 Jul;103(1):57-64.
32. Rafique MB, Stuth EA, Tassone JC. Increased blood loss during posterior spinal fusion for idiopathic scoliosis in an adolescent with Fontan physiology. Paediatr Anaesth. 2006 Feb;16(2):206-12.
33. Brandes IF, Zuperku EJ, Stucke AG, Jakovcevic D, Hopp FA, Stuth EA. Serotonergic modulation of inspiratory hypoglossal motoneurons in decerebrate dogs. J Neurophysiol. 2006 Jun;95(6):3449-59. PMCID: PMC2582383
34. Brandes IF, Stuth EA. Use of BIS monitor in a child with congenital insensitivity to pain with anhidrosis. Paediatr Anaesth. 2006 Apr;16(4):466-70.
35. Berens RJ, Stuth EA, Robertson FA, Jaquiss RD, Hoffman GM, Troshynski TJ, Staudt SR, Cava JR, Tweddell JS, Bert Litwin S. Near infrared spectroscopy monitoring during pediatric aortic coarctation repair. Paediatr Anaesth. 2006 Jul;16(7):777-81.
36. Brandes IF, Zuperku EJ, Dean C, Hopp FA, Jakovcevic D, Stuth EA. Retrograde labeling reveals extensive distribution of genioglossal motoneurons possessing 5-HT2A receptors throughout the hypoglossal nucleus of adult dogs. Brain Res. 2007 Feb 09;1132(1):110-9.
37. Brandes IF, Zuperku EJ, Stucke AG, Hopp FA, Jakovcevic D, Stuth EA. Isoflurane depresses the response of inspiratory hypoglossal motoneurons to serotonin in vivo. Anesthesiology. 2007 Apr;106(4):736-45.
38. Zuperku EJ, Brandes IF, Stucke AG, Sanchez A, Hopp FA, Stuth EA. Major components of endogenous neurotransmission underlying the discharge activity of hypoglossal motoneurons in vivo. Adv Exp Med Biol. 2008;605:279-84.
39. Sanchez A, Stuth EA, Lew SM. Postoperative upper extremity hemiplegia in a toddler following general anesthesia for drainage of a subgaleal fluid collection. Paediatr Anaesth. 2008 Jun;18(6):564-6.
40. Stuth EA, Stucke AG, Brandes IF, Zuperku EJ. Anesthetic effects on synaptic transmission and gain control in respiratory control. Respir Physiol Neurobiol. 2008 Dec 10;164(1-2):151-9.
41. Stucke AG, Zuperku EJ, Sanchez A, Tonkovic-Capin M, Tonkovic-Capin V, Mustapic S, Stuth EA. Opioid receptors on bulbospinal respiratory neurons are not activated during neuronal depression by clinically relevant opioid concentrations. J Neurophysiol. 2008 Nov;100(5):2878-88. PMCID: PMC2585400
42. Sanchez A, Mustapic S, Zuperku EJ, Stucke AG, Hopp FA, Stuth EA. Role of inhibitory neurotransmission in the control of canine hypoglossal motoneuron activity in vivo. J Neurophysiol. 2009 Mar;101(3):1211-21. PMCID: PMC2666418
43. Mustapic S, Radocaj T, Sanchez A, Dogas Z, Stucke AG, Hopp FA, Stuth EA, Zuperku EJ. Clinically relevant infusion rates of mu-opioid agonist remifentanil cause bradypnea in decerebrate dogs but not via direct effects in the pre-Bötzinger complex region. J Neurophysiol. 2010 Jan;103(1):409-18. PMCID: PMC2807229
44. Müller C, Mänhardt LB, Willaschek C, Schneider EM, Stuth EA, Buchhorn R. Beta-blocker therapy and hemophagocytic lymphohistiocytosis: a case report. Cardiol Res Pract. 2010;2010:912757. PMCID: PMC2903954
45. Stuth EA, Berens RJ, Staudt SR, Robertson FA, Scott JP, Stucke AG, Hoffman GM, Troshynski TJ, Tweddell JS, Zuperku EJ. The effect of caudal vs intravenous morphine on early extubation and postoperative analgesic requirements for stage 2 and 3 single-ventricle palliation: a double blind randomized trial. Paediatr Anaesth. 2011 Apr;21(4):441-53.
46. Stuth EA, Hoffman GM. A sisyphean task: identifying physiologic risk and improving outcomes in complex congenital heart surgery. Anesthesiology. 2011 Nov;115(5):926-8.
47. Prkic I, Mustapic S, Radocaj T, Stucke AG, Stuth EA, Hopp FA, Dean C, Zuperku EJ. Pontine μ-opioid receptors mediate bradypnea caused by intravenous remifentanil infusions at clinically relevant concentrations in dogs. J Neurophysiol. 2012 Nov;108(9):2430-41. PMCID: PMC3545180
48. Stuth EA, Stucke AG, Zuperku EJ. Effects of anesthetics, sedatives, and opioids on ventilatory control. Compr Physiol. 2012 Oct;2(4):2281-367.
49. Scott JP, Costigan DJ, Hoffman GM, Simpson PM, Dasgupta M, Punzalan R, Berens RJ, Tweddell JS, Stuth EA. Increased recombinant activated factor VII use and need for surgical reexploration following a switch from aprotinin to epsilon-aminocaproic acid in infant cardiac surgery. J Clin Anesth. 2014 May;26(3):204-11.
50. Scott JP, Stuth EA, Stucke AG, Cava JR, Berens RJ. Droperidol transiently prolongs the QT interval in children undergoing single ventricle palliation. Pediatr Cardiol. 2015 Jan;36(1):196-204.
51. Zuperku EJ, Prkic I, Stucke AG, Miller JR, Hopp FA, Stuth EA. Automatic classification of canine PRG neuronal discharge patterns using K-means clustering. Respir Physiol Neurobiol. 2015 Feb 01;207:28-39. PMCID: PMC4638195
52. Stucke AG, Miller JR, Prkic I, Zuperku EJ, Hopp FA, Stuth EA. Opioid-induced Respiratory Depression Is Only Partially Mediated by the preBötzinger Complex in Young and Adult Rabbits In Vivo. Anesthesiology. 2015 Jun;122(6):1288-98. PMCID: PMC4639929
53. Radocaj T, Mustapic S, Prkic I, Stucke AG, Hopp FA, Stuth EA, Zuperku EJ. Activation of 5-HT1A receptors in the preBötzinger region has little impact on the respiratory pattern. Respir Physiol Neurobiol. 2015 Jul;212-214:9-19.
54. Prkic I, Stuth EA. Near-infrared spectroscopy provides continuous monitoring of compromised lower extremity perfusion during cardiac surgery. J Clin Anesth. 2016 Jun;31:38-41.
55. Zuperku EJ, Stucke AG, Hopp FA, Stuth EA. Characteristics of breathing rate control mediated by a subregion within the pontine parabrachial complex. J Neurophysiol. 2017 Mar 01;117(3):1030-1042. PMCID: PMC5338614
56. Abadeer MN, Stuth EA, Kouretas PC, Ginde S, Jacobsen R, Woods RK. Scimitar Syndrome-Complex Surgical Revision 3 Decades After Repair. Ann Thorac Surg. 2017 Feb;103(2):e183-e185.
57. Miller JR, Zuperku EJ, Stuth EAE, Banerjee A, Hopp FA, Stucke AG. A Subregion of the Parabrachial Nucleus Partially Mediates Respiratory Rate Depression from Intravenous Remifentanil in Young and Adult Rabbits. Anesthesiology. 2017 Sep;127(3):502-514. PMCID: PMC5561451
58. Scott JP, Niebler RA, Stuth EAE, Newman DK, Tweddell JS, Bercovitz RS, Benson DW, Cole R, Simpson PM, Yan K, Woods RK. Rotational Thromboelastometry Rapidly Predicts Thrombocytopenia and Hypofibrinogenemia During Neonatal Cardiopulmonary Bypass. World J Pediatr Congenit Heart Surg. 2018 Jul;9(4):424-433.
59. Zuperku EJ, Stucke AG, Krolikowski JG, Tomlinson J, Hopp FA, Stuth EA. Inputs to medullary respiratory neurons from a pontine subregion that controls breathing frequency. Respir Physiol Neurobiol. 2019 Jul;265:127-140. PMCID: PMC6310670
60. Cook-Snyder DR, Miller JR, Navarrete-Opazo AA, Callison JJ, Peterson RC, Hopp FA, Stuth EAE, Zuperku EJ, Stucke AG. The contribution of endogenous glutamatergic input in the ventral respiratory column to respiratory rhythm. Respir Physiol Neurobiol. 2019 Feb;260:37-52. PMCID: PMC6397772
61. Maroney SA, Peterson JA, Zwifelhofer W, Martinez ND, Yan K, Niebler RA, Stuth EAE, Scott JP, Bercovitz RS, Woods RK, Mast AE. Erratum to: "Erratum to: Plasma proteolytic cascade activation during neonatal cardiopulmonary bypass surgery". Thromb Haemost. 2019 Jan;119(1):187.
62. Hoffman GM, Scott JP, Ghanayem NS, Stuth EA, Mitchell ME, Woods RK, Hraska V, Niebler RA, Bertrandt RA, Mussatto KA, Tweddell JS. Identification of Time-Dependent Risks of Hemodynamic States After Stage 1 Norwood Palliation. Ann Thorac Surg. 2020 Jan;109(1):155-162.
63. Zwifelhofer NMJ, Bercovitz RS, Cole R, Yan K, Simpson PM, Moroi A, Newman PJ, Niebler RA, Scott JP, Stuth EAD, Woods RK, Benson DW, Newman DK. Platelet Function Changes during Neonatal Cardiopulmonary Bypass Surgery: Mechanistic Basis and Lack of Correlation with Excessive Bleeding. Thromb Haemost. 2020 Jan;120(1):94-106. PMCID: PMC7003188
64. Navarrete-Opazo AA, Cook-Snyder DR, Miller JR, Callison JJ, McCarthy N, Palkovic B, Stuth EAE, Zuperku EJ, Stucke AG. Endogenous glutamatergic inputs to the Parabrachial Nucleus/Kölliker-Fuse Complex determine respiratory rate. Respir Physiol Neurobiol. 2020 Jun;277:103401. PMCID: PMC7309965
65. Hoffman GM, Niebler RA, Scott JP, Bertrandt RA, Wakeham MK, Thompson NE, Ghanayem NS, Stuth EA, Mitchell ME, Woods RK, Hraska V, Mussatto KA, Tweddell JS. Interventions Associated With Treatment of Low Cardiac Output After Stage 1 Norwood Palliation. Ann Thorac Surg. 2021 May;111(5):1620-1627.
66. Palkovic B, Marchenko V, Zuperku EJ, Stuth EAE, Stucke AG. Multi-Level Regulation of Opioid-Induced Respiratory Depression. Physiology (Bethesda). 2020 Nov 01;35(6):391-404. PMCID: PMC7864237
67. Hoffman GM, Scott JP, Stuth EA. Effects of Arterial Carbon Dioxide Tension on Cerebral and Somatic Regional Tissue Oxygenation and Blood Flow in Neonates After the Norwood Procedure With Deep Hypothermic Cardiopulmonary Bypass. Front Pediatr. 2022;10:762739. PMCID: PMC8873518
68. Palkovic B, Cook-Snyder D, Callison JJ, Langer TM 3rd, Nugent R, Stuth EAE, Zuperku EJ, Stucke AG. Contribution of the caudal medullary raphe to opioid induced respiratory depression. Respir Physiol Neurobiol. 2022 May;299:103855. PMCID: PMC8897277
69. Palkovic B, Callison JJ, Marchenko V, Stuth EAE, Zuperku EJ, Stucke AG. Dose-dependent Respiratory Depression by Remifentanil in the Rabbit Parabrachial Nucleus/Kölliker-Fuse Complex and Pre-Bötzinger Complex. Anesthesiology. 2021 Oct 01;135(4):649-672. PMCID: PMC8489159
70. Zuperku EJ, Hopp FA, Stuth EAE, Stucke AG. Interaction between the pulmonary stretch receptor and pontine control of expiratory duration. Respir Physiol Neurobiol. 2021 Nov;293:103715. PMCID: PMC8418273
71. Benson JW, Hraska V, Scott JP, Stuth EAE, Yan K, Zhang J, Niebler RA. Comparison of Prothrombin Complex Concentrate with Activated Factor VII Use for Bleeding Following Cardiopulmonary Bypass in Children. World J Pediatr Congenit Heart Surg. 2023 May;14(3):282-288.
72. Palkovic B, Mustapic S, Saric I, Stuth EAE, Stucke AG, Zuperku EJ. Changes in pontine and preBötzinger/Bötzinger complex neuronal activity during remifentanil-induced respiratory depression in decerebrate dogs. Front Physiol. 2023;14:1156076. PMCID: PMC10285059