CURRICULUM VITAE
Jonathan S. Marchant PhD
Jonathan S. Marchant PhD
Chair, Professor
Department of Cell Biology, Neurobiology and Anatomy
Department of Cell Biology, Neurobiology and Anatomy
OFFICE ADDRESS: |
Basic Science Building |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Chulkov EG, Smith E, Rohr CM, Yahya NA, Park SK, Scampavia L, Spicer TP, Marchant JS. Identification of novel modulators of a schistosome transient receptor potential channel targeted by praziquantel. PLoS Negl Trop Dis. 2021 Nov;15(11):e0009898. PMCID: PMC8565742 |
2. Ubah OC, Lake EW, Gunaratne GS, Gallant JP, Fernie M, Robertson AJ, Marchant JS, Bold TD, Langlois RA, Matchett WE, Thiede JM, Shi K, Yin L, Moeller NH, Banerjee S, Ferguson L, Kovaleva M, Porter AJ, Aihara H, LeBeau AM, Barelle CJ. Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography Nature Communications. December 2021;12(1). |
3. Clec'h WL, Chevalier FD, Mattos ACA, Strickland A, Diaz R, McDew-White M, Rohr CM, Kinung'hi S, Allan F, Webster BL, Webster JP, Emery AM, Rollinson D, Djirmay AG, Al Mashikhi KM, Al Yafae S, Idris MA, Moné H, Mouahid G, LoVerde P, Marchant JS, Anderson TJC. Genetic analysis of praziquantel response in schistosome parasites implicates a transient receptor potential channel Science Translational Medicine. 22 December 2021;13(625). |
4. Park SK, Friedrich L, Yahya NA, Rohr CM, Chulkov EG, Maillard D, Rippmann F, Spangenberg T, Marchant JS. Mechanism of praziquantel action at a parasitic flatworm ion channel Science Translational Medicine. 22 December 2021;13(625). |
5. Le Clec'h W, Chevalier FD, Mattos ACA, Strickland A, Diaz R, McDew-White M, Rohr CM, Kinung'hi S, Allan F, Webster BL, Webster JP, Emery AM, Rollinson D, Djirmay AG, Al Mashikhi KM, Al Yafae S, Idris MA, Moné H, Mouahid G, LoVerde P, Marchant JS, Anderson TJC. Genetic analysis of praziquantel response in schistosome parasites implicates a transient receptor potential channel. Sci Transl Med. 2021 Dec 22;13(625):eabj9114. PMCID: PMC9491494 |
6. Park SK, Friedrich L, Yahya NA, Rohr CM, Chulkov EG, Maillard D, Rippmann F, Spangenberg T, Marchant JS. Mechanism of praziquantel action at a parasitic flatworm ion channel. Sci Transl Med. 2021 Dec 22;13(625):eabj5832. PMCID: PMC8855674 |
7. Gunaratne GS, Marchant JS. The ins and outs of virus trafficking through acidic Ca<sup>2+</sup> stores Cell Calcium. March 2022;102. |
8. Patel S, Yuan Y, Gunaratne GS, Rahman T, Marchant JS. Activation of endo-lysosomal two-pore channels by NAADP and PI(3,5)P<inf>2</inf>. Five things to know. Cell Calcium. May 2022;103. |
9. Marchant JS, Gunaratne GS, Cai X, Slama JT, Patel S. NAADP-binding proteins find their identity. Trends Biochem Sci. 2022 Mar;47(3):235-249. PMCID: PMC8840967 |
10. Patel S, Gunaratne GS, Marchant JS, Biggin PC, Rahman T. NAADP receptors: A one-two. Cell Calcium. 2021 Dec;100:102478. PMCID: PMC9552928 |
11. Ubah OC, Lake EW, Gunaratne GS, Gallant JP, Fernie M, Robertson AJ, Marchant JS, Bold TD, Langlois RA, Matchett WE, Thiede JM, Shi K, Yin L, Moeller NH, Banerjee S, Ferguson L, Kovaleva M, Porter AJ, Aihara H, LeBeau AM, Barelle CJ. Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography. Nat Commun. 2021 Dec 16;12(1):7325. PMCID: PMC8677774 |
12. Sprague DJ, Kaethner M, Park SK, Rohr CM, Harris JL, Maillard D, Spangenberg T, Lundström-Stadelmann B, Marchant JS. The Anthelmintic Activity of Praziquantel Analogs Correlates with Structure-Activity Relationships at TRPM<sub>PZQ</sub> Orthologs. ACS Med Chem Lett. 2023 Nov 09;14(11):1537-1543. PMCID: PMC10641913 |
13. Sprague DJ, Park SK, Gramberg S, Bauer L, Rohr CM, Chulkov EG, Smith E, Scampavia L, Spicer TP, Haeberlein S, Marchant JS. Target-based discovery of a broad spectrum flukicide. bioRxiv. 2023 Sep 22. PMCID: PMC10542552 |
14. Gunaratne GS, Brailoiu E, Kumar S, Yuan Y, Slama JT, Walseth TF, Patel S, Marchant JS. Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12. Sci Signal. 2023 Aug 22;16(799):eadg0485. PMCID: PMC10639087 |
15. Saito R, Mu Q, Yuan Y, Rubio-Alarcón M, Eznarriaga M, Zhao P, Gunaratne G, Kumar S, Keller M, Bracher F, Grimm C, Brailoiu E, Marchant JS, Rahman T, Patel S. Convergent activation of Ca<sup>2+</sup> permeability in two-pore channel 2 through distinct molecular routes. Sci Signal. 2023 Aug 22;16(799):eadg0661. PMCID: PMC10639088 |
16. Gunaratne GS, Kumar S, Lin-Moshier Y, Slama JT, Brailoiu E, Patel S, Walseth TF, Marchant JS. Progesterone receptor membrane component 1 facilitates Ca<sup>2+</sup> signal amplification between endosomes and the endoplasmic reticulum. J Biol Chem. 2023 Dec;299(12):105378. PMCID: PMC10685313 |
17. Friedrich L, Park SK, Ballard P, Ho Baeurle TH, Maillard D, Bödding M, Keiser J, Marchant JS, Spangenberg T. Metabolism of (R)-Praziquantel versus the Activation of a Parasite Transient Receptor Potential Melastatin Ion Channel. ChemMedChem. 2023 Sep 15;18(18):e202300140. PMCID: PMC10530395 |
18. Yahya NA, Lanham JK, Sprague DJ, Palygin O, McCorvy JD, Marchant JS. Molecular and cellular basis of praziquantel action in the cardiovascular system. Am J Physiol Cell Physiol. 2023 Feb 01;324(2):C573-C587. PMCID: PMC9942900 |
19. Chulkov EG, Palygin O, Yahya NA, Park SK, Marchant JS. Electrophysiological characterization of a schistosome transient receptor potential channel activated by praziquantel. Int J Parasitol. 2023 Jul;53(8):415-425. PMCID: PMC10258134 |
20. Chulkov EG, Isaeva E, Stucky CL, Marchant JS. Use the force, fluke: Ligand-independent gating of Schistosoma mansoni ion channel TRPM<sub>PZQ</sub>. Int J Parasitol. 2023 Jul;53(8):427-434. PMCID: PMC10258140 |
21. Rohr CM, Sprague DJ, Park SK, Malcolm NJ, Marchant JS. Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity. Proc Natl Acad Sci U S A. 2023 Jan 03;120(1):e2217732120. PMCID: PMC9910428 |
22. Gunaratne GS, Rebbeck RT, McGurran LM, Yan Y, Arzua T, Frolkis T, Sprague DJ, Bai X, Cornea RL, Walseth TF, Marchant JS. Identification of a dihydropyridine scaffold that blocks ryanodine receptors. iScience. 2022 Jan 21;25(1):103706. PMCID: PMC8760560 |
23. Park SK, Sprague DJ, Rohr CM, Chulkov EG, Petrow I, Kumar S, Marchant JS. The anthelmintic meclonazepam activates a schistosome transient receptor potential channel. J Biol Chem. 2024 Jan;300(1):105528. PMCID: PMC10788528 |
24. Sprague DJ, Park SK, Gramberg S, Bauer L, Rohr CM, Chulkov EG, Smith E, Scampavia L, Spicer TP, Haeberlein S, Marchant JS. Target-based discovery of a broad-spectrum flukicide. Nat Struct Mol Biol. 2024 Sep;31(9):1386-1393. PMCID: PMC12169134 |
25. Marchant JS. Progress interrogating TRPMPZQ as the target of praziquantel. PLoS Negl Trop Dis. 2024 Feb;18(2):e0011929. PMCID: PMC10868838 |
26. Sprague DJ, Rohr CM, Marchant JS. TRP drop, TRP drop: a steady patter of anti-schistosomal target illumination. Front Parasitol. 2024;3:1349623. PMCID: PMC11731825 |
27. Mu Q, Harris JL, Yule DI, Slama JT, Marchant JS, Patel S. NAADP signaling: Master manipulation. Cell Calcium. 2024 Dec;124:102969. |
28. Chulkov EG, Rohr CM, Marchant JS. Praziquantel activates a native cation current in <i>Schistosoma mansoni</i>. Front Parasitol. 2023;2:1285177. PMCID: PMC11732042 |
Non-Peer Reviewed Educational Products |
1. Rohr CM, Marchant JS. The sigma 1 receptor: A local media influencer. Cell Calcium. 2021 Jul;97:102430. |
