CURRICULUM VITAE
Juliana Perez Botero MD
Juliana Perez Botero MD
Assistant Professor
Department of Medicine
Division of Hematology and Oncology - Medicine
Department of Medicine
Division of Hematology and Oncology - Medicine
OFFICE ADDRESS: |
Froedtert Hospital |
9200 W Wisconsin Ave |
Milwaukee, WI 53226 |
Email: jperezbotero@mcw.edu |
EDUCATION: |
08/2003 - 06/2010 M.D. Universidad de los Andes, Bogotá, Colombia |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
06/2011 - 06/2014 Resident, Department of Internal Medicine, Mayo Clinic School of Graduate Medical Education, 200 First Street SW, Rochester, MN 55905 |
07/2014 - 06/2017 Fellow, Department of Internal Medicine, Division Hematology and Division of Oncology Medicine, Mayo Clinic School of Graduate Medical Education, 200 First Street SW, Rochester, MN 55905 |
FACULTY APPOINTMENTS: |
10/2017 - Present Assistant Professor, Department of Medicine, The Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226 |
03/2018 - Present Member, Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226 |
06/2020 - 01/2022 Assistant Investigator, Laboratory Track, Blood Research Institute, Versiti, 8727 W Watertown Plank Rd, Milwaukee, WI 53226 |
09/2020 - Present Medical Director, Molecular Oncology and Genetics Laboratory, Diagnostic Laboratories, Versiti, 638 N 18th St, Milwaukee, WI 53233 |
02/2022 - Present Associate Investigator, Laboratory Track, Blood Research Institute, Versiti, 8727 W Watertown Plank Rd, Milwaukee, WI 53226 |
EDUCATIONAL ADMINISTRATIVE APPOINTMENTS: |
07/2016 - 06/2017 Chief Fellow, Medicine, Hematology and Oncology, Mayo Clinic, 200 First St, Rochester, MN 55905 |
HOSPITAL STAFF PRIVILEGES: |
10/2017 - Present Attending Physician, Froedtert Memorial Lutheran Hospital, 9200 W. Wisconsin Ave., Milwaukee, WI 53226 |
12/2022 - Present Attending Physician, Children's Hospital of Wisconsin, 9000 W. Wisconsin Ave, Milwaukee, WI 53226 |
SPECIALTY BOARDS AND CERTIFICATION: |
Board Certified | Issue Date | Expiration |
American Board of Internal Medicine | 10/2014 | 10/2024 |
ABIM - Hematology | 10/2017 | 10/2027 |
ABIM- Oncology | 10/2017 | 10/2027 |
Licensure | Number | Issue Date | Expiration |
Medico | 53001687 | 07/2011 | None |
Minnesota License | 56682 | 07/13/2013 | 05/31/2018 |
Wisconsin License | 67665-20 | 10/31/2021 | 10/31/2023 |
AWARDS AND HONORS: |
07/2007 - 06/2008 Ramon de Zubiria Scholarship, Universidad de los Andes, Colombia |
07/2009 Best final year Medical Student, Fundacion Santa Fe Hospital, Bogota, Colombia |
11/2009 Top 10 scores nationwide in the Medicine ECAES, National Examination for the Quality of Higher Education |
06/2010 Cum Laude Graduate, Faculty of Medicine , Universidad de los Andes, Colombia |
03/01/2012 - 03/31/2012 Intern of the month, General Medicine wards, Mayo Clinic |
2014 Attendance and travel award on a national competitive basis , The Hematology Fellows Consortium |
04/2017 Hemostasis and Thrombosis Research Society Travel Award, HTRS |
06/2017 Outstanding Hematology-Oncology Trainee, Hematology and Oncology Fellowship, Mayo Clinic, Rochester |
2021 Significant Contributors Award. To 22/1700 contributors worldwide that have gone above and beyond to further the work and impact and excelled in dedicated work and effort to ClinGen, ClinGen |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
2008 - 2009 American College of Physicians (Student Member) |
2011 - 2017 American College of Physicians (Associate Member) |
2011 - 2014 American Medical Association (Member) |
2012 - 2013 Hemostasis and Thrombosis Research Society (Trainee Member) |
2014 - 2017 Hemostasis and Thrombosis Research Society (Associate Member) |
2014 - 2017 American Society of Clinical Oncology (Member in Training) |
2014 - 2017 American Society of Hematology (Associate Member) |
2015 - 2017 International Society on Thrombosis and Haemostasis (Associate Member) |
2017 - Present International Society on Thrombosis and Haemostasis (Member) |
2017 - Present Hemostasis and Thrombosis Research Society (Core Member) |
2017 - Present American Society of Hematology (Member ) |
2018 - Present Foundation for Women & Girls with Blood Disorders (Member ) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorial Board |
2017 - 2018 Journal of Hematology and Multiple Myeloma |
07/2022 - 12/2022 ASH News Daily, official print publication of the American Society of Hematology annual meeting |
Ad-Hoc Reviewer |
2017 - Present Platelets |
2017 - Present Blood Coagulation and Fibrinolysis |
2017 - Present Clinical Medicine Insights |
2017 - Present Technology in Cancer Research |
2019 - Present Haemophilia |
2020 - Present Blood Advances |
2020 - Present American Journal of Perinatology |
2020 - Present Blood |
2022 - Present American Journal of Medical Genetics |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
04/2018 - 02/2021 Member, American Society of Hematology representative to the National multidisciplinary Thrombocytopenia in Pregnancy Taskforce to establish guidelines for the management of neuraxial anesthesia, Society for Obstetric Anesthesia and Perinatology |
INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
05/2018 - Present Member, Platelet Disorders Expert Panel. One of 16 international experts in inherited platelet disorders. Group created to evaluate the clinical validity of gene-disease relationships and pathogenicity of individual genetic variants to implement standardized protocols for gene or sequence variant specific annotations of genes., ClinGen |
01/2019 - Present Member, Hemostasis and Thrombosis Gene Curation Expert Panel. Part of the NIH funded Clinical Genome Resource. One of 12 international experts in a group formed to evaluate the clinical validity of gene-disease relationships and pathogenicity of individual genetic variants., ClinGen |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
Local |
Perez Botero J, Clinical molecular testing, Center for Bleeding Disorders Agenda Driven Meeting, Versiti, Milwaukee, WI, 02/2020 |
Perez Botero J, McIntosh JJ, Blood, Sweat and Tears – The Challenges of Hematologic Disorders in Pregnancy, Department of Medicine Grand Rounds, Medical College of Wisconsin, Milwaukee, WI, 05/2020 |
Perez Botero J, McIntosh JJ, Blood, Sweat and Tears – The Challenges of Hematologic Disorders in Pregnancy, Department of Obstetrics and Gynecology Grand Rounds, Medical College of Wisconsin, Milwaukee, WI, 07/2020 |
Palmer E, Malec L, Perez Botero J, Hemophilia B Leyden vs Brandenburg case presentation, Comprehensive Center for Bleeding Disorders Agenda Driven meeting, Versiti, Milwaukee, WI, 10/2022 |
Regional |
Perez Botero J, Dugan SN, Navigating Genetic Testing for Inherited Disorders of Hemostasis, BloodFlow Educational Webinar, Versiti, Milwaukee, WI, 11/11/2021 |
National |
Perez Botero J, Congenital/hereditary Thrombocytopenias and Thrombocytopathies, 16th Bleeding and Thrombosing Diseases Conference and Workshop. Mayo Medical Laboratories, Mayo Clinic, Rochester, MN, 09/13/2017 |
Yuen, L with J Perez Botero as invited facilitator, Platelets as sticky as dry leaves in autumn, Massachusetts General Hospital Hematology Seminar, Virtual, 06/2021 |
Perez Botero J, Lambert M, Oral abstract moderator category 311: Disorders of Platelet Number or Function: Clinical and Epidemiological., American Society of Hematology Annual meeting, Atlanta, GA, 12/2021 |
Perez Botero J, Inherited Platelet Disorders, Plasma Academy Educational Program, Virtual, 01/21/2022 |
Perez Botero J, Hematologic Disorders Affecting Pregnancy, Plasma Academy Educational Program, Virtual, 01/21/2022 |
Perez botero J, Shimano K, Oral abstract moderator category 311: Disorders of Platelet Number or Function: Clinical and Epidemiological., American Society of Hematology Annual Meeting, New Orleans, LA, 12/2022 |
Perez Botero J, Engaging Clinicians, Laboratorians and Scientists for Analysis and Interpretation of Complex Testing: The Story of the Versiti Hematology Genetics Team, Department of Laboratory Medicine, Clinical Visiting Professorship, New York Presbyterian Hospital, Cornell University, New York City, NY, 03/23/2023 |
International |
Perez Botero, J, Recommendations for identification and management of patients with suspected VITT after COVID19 vaccination, General Hospital Medical Updates, Fundacion Santa Fe de Bogota, Bogota, Colombia, 04/21/2021 |
Perez Botero J, Evaluation of Hypercoagulability in Stroke, NeuroLili21: VI Colombian Stroke Conference, Medellin, Colombia, 11/20/2021 |
Chen, V, Perez Botero J, Bastida JM, New and Emerging Assays to Investigate Bleeding Disorders of Unknown Cause, International Society on Thrombosis and Haemostasis (ISTH) Academy, Virtual, 05/2023 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
Regional |
Perez Botero J, Verdoorn B, Schmidt E, Desai S, Greenlund A, A case of hypothenar hammer syndrome in a non-smoking male requiring surgery. Poster., American College of Physicians Minnesota Chapter Meeting., Minneapolis, MN, 2011 |
Perez Botero J, Pedersen K, Haberman T, EBV positive primary CNS lymphoma in a patient with autoimmune cerebellar ataxia treated with mycophenolate. Poster., American College of Physicians, Minnesota Chapter Meeting, Minneapolis, MN, 2012 |
Perez Botero, J, Chen D, Majerus JA, Coon LM, He R, Warad DM, Pruthi RK, Nichols WL, Hermansky-Pudlak Syndrome: when oculocutaneous albinism
is more than meets the eye., Poster., American College of Physicians Minnesota Chapter Meeting., Minneapolis, MN, 2016 |
National |
Perez Botero J, Carrillo G, Mieth K, Pesantez R, Leal C, Navas J, Zayed G, Llinas A, Introduction of new anticoagulants for deep venous thrombosis. Oral abstract., 56th Annual Meeting of the Colombian Orthopedics Society, Cartagena, Colombia, 05/12/2011 |
Perez Botero J, Pruthi RK, Refractory bleeding from intestinal angiodysplasias successfully treated with danazol in 3 patients with von Willebrand’s disease. Poster., Hemostasis and Thrombosis Research Society Scientific Symposium, Charlotte, NC, 04/2013 |
Perez Botero J, Anderson J, Graner K,Pruthi RK, Determination of the incidence of clinically diagnosed heparin induced thrombocytopenia in 5123 consecutive patients exposed to heparin. Poster., Hemostasis and Thrombosis Research Society Scientific Symposium, Charlotte, NC, 2013 |
Perez Botero, J, Spoon DB, Patnaik MS, Ashrani AA, Trousdale RT, Pruthi RK, Incidence Of Symptomatic Venous Thromboembolism In Patients With Hemophilia Undergoing Joint Replacement Surgery: A Retrospective Study. Poster., American Society of Hematology Annual Meeting, New Orleans, LA, 2013 |
Perez Botero J, Ormsby WD, Ashrani AA, McBane RD 2nd, Wysokinski WE, Patnaik MM, Lewis BR, Grill DE, Pruthi RK, Heit JA, Prevalence of Venous and Arterial Thrombosis among 268 Heterozygous and 111 Homozygous Factor V Leiden Carriers: A Single-Center Cross-Sectional Study. Poster., American Society of Hematology Annual Meeting, San Francisco 2014, 2014 |
Perez Botero J, Pruthi RK, Nichols WL, Patnaik MM, Von Willebrand Disease Type1/Type 2N Compound Heterozygotes: Diagnostic and Management Challenges, Hemostasis and Thrombosis Research Society Scientific Symposium, New Orleans, LA, 2015 |
Perez Botero J, DM Warad, H Rong, RK Pruthi, D Chen, Value of Platelet Esoteric Testing in Laboratory Diagnosis of Platelet Disorders: A Single Center Experience. Poster., American Society of Hematology, Orlando, FL, 2015 |
Perez Botero J, Cardel LK, Ashrani AA, Heit JA, He R, Hook CC, McBane RD, Pardanani A, Warad DM, Wysokinski WE, Rodriguez V, Nichols WL, Pruthi RK, Chen D, Patnaik MM, Platelet Transmission Electron Microscopy and Flow Cytometry in the Diagnosis of Congenital/Hereditary Qualitative or Quantitative Platelet Disorders. Poster., American Society of Hematology Annual Meeting, Orlando, FL, 2015 |
Perez Botero J, Cheng D, Patnaik MM, Comparing the platelet ultrastructural phenotype in ANKRD26 and RUNX1 mutated thrombocytopenias. Oral presentation., Friday Scientific Workshop on Inherited Hematopoietic Malignancies, American Society of Hematology Annual Meeting., San Diego, CA, 12/2016 |
Ho TH, Perez Botero J, Hogan WJ, Kenderian S, Gangat N, Tefferi A, Abraham RS, Nguyen P, Oliveira JL, He R, Chen D, Viswanatha D, Rodriguez V, Khan SP, Patnaik MM, Clinical Spectrum of Germline Mutations with Predisposition to Myeloid Neoplasms- 2016 World Health Organization Classification Update. Oral abstract., American Society of Hematology Annual Meeting, San Diego, CA, 12/2016 |
Perez Botero J, LM Coon, JA Majerus, Chen D, Pruthi RK, F9 genotyping trends and spectrum of mutations identified – A reference laboratory experience., Thrombosis and Hemostasis Societies of North America Summit, Chicago, IL, 2016 |
Majerus JA, Coon LM, Turley E, Nichols WL, Pruthi RK, He R, Viswanatha DS, Chen D, Perez Botero J, Algorithmic Approach to the Diagnosis of Hermansky–Pudlak Syndromes by Using Both Platelet Electron Microscopy and Targeted Next Generation Sequencing.
AMP 2016 Annual meeting. Poster., Association for Molecular Pathology Annual meeting, Charlotte, NC, 2016 |
Perez Botero J, Ho TH, Rodriguez V, Khan SP, Pruthi RK, Patnaik MM, Coagulation abnormalities and Hemostatic Surgical Outcomes in 142 patients with Noonan Syndrome. Poster., American Society of Hematology Annual Meeting, San Diego, CA, 2016 |
Marshal AL, Perez Botero J, Ashrani AA, Pruthi RK, Heit JA, Chintakuntlawar A, Guenther JA, Patnaik MM, The Impact of Antithrombin Deficiency on Women’s Reproductive Health Experiences and Healthcare Decision-Making: A Qualitative Patient-Oriented Survey Study. Poster., American Society of Hematology Annual Meeting, San Diego, CA, 2016 |
Perez Botero J, Dulleman PM, Gandhi MJ, Wakefield LL, De Goey SR, Kreuter JD, Single Antigen Bead Results Complement Platelet Crossmatch in Selecting Platelet Units Leading to Adequate Transfusion Yield in Refractory Patients, American Society of Hematology Annual Meeting, San Diego, CA, 2016 |
Perez Botero J, Cardel LK, Ashrani AA, Heit JA, He R, Hook CC, McBane RD, Pardanani A, Warad DM, Wysokinski WE, Rodriguez V, Nichols WL, Chen D, Patnaik MM, Pruthi RK, Laboratory Profiles for Evaluation of Bleeding Disorders are High-Cost Low-Yield Tests in the General Medical Practice. Poster., Hemostasis and Thrombosis Research Society Scientific Symposium, Scottsdale, AZ, 2017 |
Dugan SN, Sullivan MJ, Springer MG, Trapp-Stamborski V, McCreery J, Sharma Ruchika, Friedman KD, Curtis BR, Wang L, Jobe SM, Perez Botero J, RUNX1-related Familial Platelet Disorder with Predisposition to Acute Myeloid Leukemia (FPD/AML) Presenting with Bleeding and Normal Platelet Count: the Importance of Recognizing the Platelet Dysfunction as part of the Phenotype. Poster., Thrombosis & Hemostasis Societies of North America, San Diego, CA, 2018 |
Sharma R, Perez-Botero J, Sullivan MJ, Trapp-Stamborski V, Springer M, Gilbert T, McCreery JM, Dugan SN, Wang L, Haberichter SL, Friedman KD, Distribution of Pathogenic Variants in Von Willebrand Disease Type 2A in the American Population: Results from a National Clinical Reference Laboratory. Poster., American Society of Hematology Annual Meeting, San Diego, CA, 2018 |
McBane RD, Wysokinski WE, Le-Rademacher J, Ashrani AA, Tafur AJ, Gundabolu K, Perez-Botero J, Perepu U, Anderson DM, Kuzma C, Leon Ferre R, Henkin S, Lenz C, Loprinzi C, Apixaban, Dalteparin, in Active Cancer Associated Venous Thromboembolism, the ADAM VTE Trial. Oral abstract., American Society of Hematology Annual Meeting, San Diego, CA, 2018 |
Wang l, SullivanMJ,Dugan SN, Trapp-Stamborski V, McCreery J, Springer1 MG, Rauscher D, Tracy S, Dash DP, Friedman KD, 2, Perez Botero J, Definitive Diagnosis of Gray Platelet Syndrome (GPS) Established by Identification of Novel NBEAL2 Pathogenic Variants Highlights the Utility of Next-generation Sequencing (NGS) for Diagnosing Rare Platelet Disorders. Poster., American College of Medical Genetics and Genomics Annual Meeting, Seattle, WA, 2019 |
Malec L, Sharma S, Perez Botero J, Agostini T, Todd A, Haberichter S, Friedman K., Performance of VWF:GPIbM assay for monitoring of desmopressin (DDAVP) trials. Poster., Hemostasis and Thrombosis Research Society Scientific Symposium, New Orleans, LA, 2019 |
Dugan SN, Miller AC, Sullivan MJ, Trapp-Stamborski V, Sharma R, Friedman KD, Curtis B, McCreery J, Perez Botero J, MYH9 Diagnostic Yield: Reported Phenotypic Specificity Highlights Opportunity for Increased Clinician-Laboratory Partnership., National Society of Genetic Counselors Annual Conference, Salt Lake Ctty, UT, 2019 |
Springer MG, Perez Botero J, Sullivan MJ, Tracey S, Trapp-Stamborski V, Sharma R, McCreery J, Friedman KD, Dugan SN, Low Prevalence of Pathogenic or Likely Pathogenic Variants in a Cohort Evaluated for Genetic Causes of Atypical Hemolytic Uremic Syndrome, American College of Medical Genetics and Genomics, Virtual, 2020 |
International |
Perez Botero J, Llinas A, Duarte M, Ucros G, Pharmacovigilance in patients who underwent radiosynovectomy with colloidal chromic phosphate P 32. Oral abstract., 2th International Musculoskeletal Congress of the World Federation of Hemophilia., Dubai, United Arab Emirates, 04/2011 |
Ho TH, Perez Botero J, Hogan WJ, Kenderian S, Gangat N, Tefferi A, Abraham RS, Nguyen P, Oliveira JL, He R, Chen D, Viswanatha D, Rodriguez V, Khan SP, Patnaik MM, Clinical Spectrum of Germline Mutations with Predisposition to Myeloid Neoplasms- 2016 World Health Organization Classification Update. Oral abstract., American Society of Hematology 57th Annual Meeting and Exposition., San Diego, CA, 12/04/2016 |
Perez Botero J, Diagnostic Challenges in Patients with Suspected Inherited Platelet Disorders. Oral presentation., Internal Society for Haemostasis and Thrombosis SSC meeting, Dublin, Ireland, 07/20/2018 |
Dugan SN, Sullivan MJ, Springer MG, Trapp-Stamborski V, McCreery J, Sharma Ruchika, Friedman KD, Dash DP, Curtis BR, Wang L, Anderson MW, Perez Botero J, Clinical Correlation with a Multidisciplinary Approach Facilitates the Diagnosis of Patients with a Suspected Inherited Platelet Disorder using Next Generation Sequencing. Oral abstract., World Federation of Hemophilia Congress, Glassgow, Scottland, 2018 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
2020 - 2023 Co-Chair, LGBTQ+ Employee Resource Group, MCW |
Hospital |
11/2020 - Present Member, Diversity & Inclusion Council, Versiti |
2020 Hematology representative, Working group to develop an IV iron protocol for inpatients at Froedtert Hospital, Froedtert |
02/2021 - Present Member, Continuous Medical Education Committee, Versiti |
04/2022 - Present Member, Conflict of Interest Committee, Versiti |
MEDICAL COLLEGE TEACHING ACTIVITIES: |
Resident and Fellow Education |
01/2018 Inherited bleeding disorders: pregnancy implications. Maternal Fetal Medicine fellow lecture series. |
02/2018 Inherited Platelet Disorders What you need to know for boards (and life). Hematology and Oncology Fellows Core Curriculum Lecture. |
06/2018 Approach to the thrombocytopenic patient. Medicine Residents Core Curriculum Lecture. |
03/2019 Hematologic disorders in pregnancy Maternal Fetal Medicine fellow lecture series. |
05/2019 Thrombotic microangiopathies. Medicine Residents Core Curriculum Lecture. |
09/2019 ITP Hematology and Oncology Fellows Core Curriculum Lecture. |
10/2019 Interpretation of CBC and other common hematology tests. Maternal Fetal Medicine fellow lecture series. |
05/2020 Approach to the thrombocytopenic patient. Medicine Residents Core Curriculum Lecture. |
05/2020 Antithrombin deficiency and pregnancy implications. Maternal Fetal Medicine fellow lecture series. |
08/2020 Overview of germline genetic testing: when and how to order and interpret results. Hematology and Oncology Fellows Core Curriculum Lecture. |
09/2020 Thrombotic microangiopathies in pregnancy. Maternal Fetal Medicine fellow lecture series. |
11/2020 Antiphospholipid antibody syndrome, Rheumatology fellowship lecture series. |
03/2021 The role of the hematologist before, during and after pregnancy. Hematology and Oncology Fellows Core Curriculum Lecture.
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05/2021 Approach to the patient with a low platelet count. Medicine Residents Core Curriculum Lecture.
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08/2021 Anticoagulation in pregnancy and postpartum
Maternal Fetal Medicine fellow lecture series.
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04/2022 Disorders of platelet function. Hematology and Oncology Fellows Core Curriculum Lecture
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05/2022 Approach to the patient with a low platelet count. Medicine Residents Core Curriculum Lecture.
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08/2022 Thrombocytopenia affecting pregnancy. Maternal Fetal Medicine fellow lecture series. |
07/2023 Laboratory tests in hematologyWhat are you ordering? Hematology and Oncology fellows orientation |
EXTRAMURAL TEACHING: |
Graduate Student Education |
06/2022 Versiti Diagnostic Laboratory, Platelet disorders for genetic counselors interactive session |
08/2022 Versiti Diagnostic Laboratory, Hematology Testing for Pregnancy and Delivery. Hemostasis and PNIL laboratory meeting. |
03/2023 Versiti Diagnostic Laboratory, Non-immune Platelet Disorders. Specialist in Blood Banking program lecture series |
04/2023 Versiti Diagnostic Laboratory, Hemophilia. Specialist in Blood Banking program lecture series |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Medical Students |
Hunter Cameron, Medical College of Wisconsin, 10/2020 - 08/2021 Academic Mentorship, Peer-reviewed publication: Cameron H, Perez Botero J. Recognition of the unique bleeding pattern and laboratory findings in acquired haemophilia A facilitates prompt treatment of a life-threatening disorder. BMJ Case Rep. 2021 Aug 3;14(8):e244238. doi: 10.1136/bcr-2021-244238. PMID: 34344656; PMCID: PMC8336148. |
Claire Stevens-Haas, Medical College of Wisconsin, 03/2022 - 12/2022 Academic mentorship, Peer reviewed publication: Peripartum management of deep venous thrombosis in the context of antithrombin deficiency and May-Thurner syndrome. Blood Coagul Fibrinolysis 2023 Apr 01;34(3):211-214 |
C. Ryan Hahn, Medical College of Wisconsin, 2023 - Present Academic mentorship, Faculty Mentor for the Medical Student Summer Research Program, Retrospective study ongoing (delivery outcomes in pregnant patients with thrombocytopenia in progress |
Clinical/Research Fellows |
Zachary Colvin, Medical College of Wisconsin, 2020 - 2021 Academic Mentorship (Fellowship Thesis Committee Member), Peer reviewed publication: Colvin ZA, Schiller J, Tsaih SW, Sharma R, Grace RF, McIntosh JJ, Curtis BR. HLA antibodies in fetal and neonatal alloimmune thrombocytopenia. Transfusion. 2023 Apr 10. doi: 10.1111/trf.17342. Epub ahead of print. PMID: 37038316. |
Christine M. Livergood, Medical College of Wisconsin, 06/2021 - 06/2022 Academic mentorship, National presentation: Can't Stop the Clot. Society for Maternal-Fetal Medicine Rare Diseases postgraduate course and Peripartum management of deep venous thrombosis in the context of antithrombin deficiency and May-Thurner syndrome. Blood Coagul Fibrinolysis 2023 Apr 01;34(3):211-214 |
Residents |
Linzi Hobbs-Parker, Medical College of Wisconsin, 2022 - Present Academic Mentorship, Retrospective clinical study in planning stages |
Samantha Lauhon, Medical College of Wisconsin, 2022 - Present Academic mentorship, Retrospective clinical study in progress (outcomes of the combined hematology/MFM clinic) |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Medical Students |
Shannon Fang, Case Western Reserve University, 2022 - 2023 Academic mentorship, Peer reviewed publication: Fang S, Botero JP, Hackney L More than just mild thrombocytopenia: clinical clues in the diagnosis of germline predisposition to malignancy from a novel ETV6 variant (in production at Clinical Case Reports) |
Residents |
Daniel Partain, Mayo Clinic, 06/2015 - 02/2016 Academic mentorship, Peer reviewed publication: Partain DK, Botero JP, Shi M, Poterucha JJ, Ashrani AA, Thompson CA. Spur cell anemia in the setting of progressive liver allograft failure. Am J Hematol. 2016 Oct;91(10):1061. doi: 10.1002/ajh.24331. Epub 2016 Mar 22. PMID: 26874796. |
Thanh Ho, Mayo Clinic, 04/2016 - 03/2017 Academic mentorship, National presentation and peer-reviewed publication: 45. Ho TH, Perez Botero J, Hogan WJ, Kenderian S, Gangat N, Tefferi A, Abraham RS, Nguyen P, Oliveira JL, He R, Chen D, Viswanatha D, Rodriguez V, Khan SP, Patnaik MM. Clinical Spectrum of Germline Mutations with Predisposition to Myeloid Neoplasms- 2016 World Health Organization Classification Update. Blood 2016 128:300 and 48. Perez Botero J, Ho TH, Hogan WJ, Kenderian S, Gangat N, Tefferi A, Abraham RS, Nguyen P, Oliveira JL, He R, Chen D, Viswanatha D, Rodriguez V, Khan SP, Patnaik MM (2017). Clinical Spectrum and Clonal Evolution in Germline Syndromes with Predisposition to Myeloid Neoplasms. Br J Haematol doi:10.1111/bjh.14746 |
Clinical Staff |
Dominka Bajguz, Versiti Diagnostic Laboratory, 10/2021 - Present Research advisor, International oral presentation: When is factor VIII deficiency not hemophilia A? Variant F8 c.1094 A>G, p.Tyr365Cys illustrates the utility of genotyping and the value of disease specific expertise in variant classification. ISTH meeting Montreal 2022 |
Mia Sullivan, Versiti Diagnostic Laboratory, 02/2022 - 06/2022 Academic mentorship, Peer reviewed manuscript: Sullivan MJ, Palmer EL, Botero JP. ANKRD26-Related Thrombocytopenia and Predisposition to Myeloid Neoplasms. Curr Hematol Malig Rep. 2022 Oct;17(5):105-112. doi: 10.1007/s11899-022-00666-4. Epub 2022 Jun 25. PMID: 35751752. |
Elizabeth Palmer, Versiti Diagnostic Laboratory, 02/2022 - 06/2022 Academic mentorship, Peer reviewed publication: Sullivan MJ, Palmer EL, Botero JP. ANKRD26-Related Thrombocytopenia and Predisposition to Myeloid Neoplasms. Curr Hematol Malig Rep. 2022 Oct;17(5):105-112. doi: 10.1007/s11899-022-00666-4. Epub 2022 Jun 25. PMID: 35751752. |
PROGRAMMATIC DEVELOPMENTS: |
Clinical Programs |
08/2017 - Present Establishment, development and leadership of the Versiti Hematology Genetics cross functional/multidisciplinary laboratory team |
02/2018 - Present Establishment and development of the combined multidisciplinary Hematology/Maternal Fetal Medicine clinic |
10/2018 - Present Establishment and development of Benign Hematology eConsults |
OTHER PEER REVIEW: |
09/2021 - 12/2021 American Society of Hematology abstract reviewer category 311: Disorders of Platelet Number or Function: Clinical and Epidemiological. |
09/2022 - 12/2022 American Society of Hematology abstract reviewer and section abstract coordinator category 311: Disorders of Platelet Number or Function: Clinical and Epidemiological. |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Go RS, Winters JL, Leung N, Murray DL, Willrich MA, Abraham RS, Amer H, Hogan WJ, Marshall AL, Sethi S, Tran CL, Chen D, Pruthi RK, Ashrani AA, Fervenza FC, Cramer CH 2nd, Rodriguez V, Wolanskyj AP, Thomé SD, Hook CC, Mayo Clinic Complement Alternative Pathway-Thrombotic Microangiopathy Disease-Oriented Group. Thrombotic Microangiopathy Care Pathway: A Consensus Statement for the Mayo Clinic Complement Alternative Pathway-Thrombotic Microangiopathy (CAP-TMA) Disease-Oriented Group. Mayo Clin Proc. 2016 Sep;91(9):1189-211. |
2. Marshall AL, Botero JP, Ashrani AA, Pruthi RK, Heit JA, Chintakuntlawar A, Guenther JC, Patnaik MM. The Impact of Antithrombin Deficiency on Women's Reproductive Health Experiences and Healthcare Decision-Making. J Womens Health (Larchmt). 2017 Dec;26(12):1350-1355. |
3. Botero JP, Chen D, Majerus JA, Coon LM, He R, Warad DM, Pruthi RK, Nichols WL. Hermansky-Pudlak syndrome subtype 5 (HPS-5) novel mutation in a 65 year-old with oculocutaneous hypopigmentation and mild bleeding diathesis: The importance of recognizing a subtle phenotype. Platelets. 2018 Jan;29(1):91-94. |
4. Perez Botero J, Coon LM, Majerus JA, Chen D, Pruthi RK. Factor IX Gene (F9) Genotyping Trends and Spectrum of Mutations Identified: A Reference Laboratory Experience. Semin Thromb Hemost. 2018 Apr;44(3):287-292. |
5. Perez Botero J, Chen D, Cousin MA, Majerus JA, Coon LM, Kruisselbrink TM, Klee EW, Lazaridis KN, Pruthi RK, Patnaik MM. Clinical characteristics and platelet phenotype in a family with RUNX1 mutated thrombocytopenia. Leuk Lymphoma. 2017 Aug;58(8):1963-1967. |
6. McBane Ii R, Loprinzi CL, Ashrani A, Perez-Botero J, Leon Ferre RA, Henkin S, Lenz CJ, Le-Rademacher JG, Wysokinski WE. Apixaban and dalteparin in active malignancy associated venous thromboembolism. The ADAM VTE Trial. Thromb Haemost. 2017 Oct 05;117(10):1952-1961. |
7. Perez Botero J, Chen D, He R, Viswanatha DS, Majerus JA, Coon LM, Nguyen PL, Reichard KK, Oliveira JL, Tefferi A, Gangat N, Pruthi RK, Patnaik MM. Clinical and laboratory characteristics in congenital ANKRD26 mutation-associated thrombocytopenia: A detailed phenotypic study of a family. Platelets. 2016 Nov;27(7):712-715. |
8. Perez Botero J, Warad DM, He R, Uhl CB, Tian S, Otteson GE, Barness RL, Olson MC, Gossman SC, Charlesworth JE, Nichols WL, Pruthi RK, Chen D. Comprehensive Platelet Phenotypic Laboratory Testing and Bleeding History Scoring for Diagnosis of Suspected Hereditary Platelet Disorders: A Single-Institution Experience. Am J Clin Pathol. 2017 Jul 01;148(1):23-32. |
9. Perez Botero J, Majerus JA, Strege AK, Johnson RD, Chen D, Pruthi RK. Diagnostic Testing Approaches for Activated Protein C Resistance and Factor V Leiden: A Comparison of Institutional and National Provider Practices. Am J Clin Pathol. 2017 Jun 01;147(6):604-610. |
10. Perez Botero J, Pruthi RK, Majerus JA, Coon LM, Uhl CB, Chen D, Patnaik MM. Practice patterns in the diagnosis of inherited platelet disorders within a single institution. Blood Coagul Fibrinolysis. 2017 Jun;28(4):303-308. |
11. Perez Botero J, Ormsby WD, Ashrani AA, McBane RD 2nd, Wysokinski WE, Patnaik MM, Lewis BR, Grill DE, Pruthi RK, Heit JA. Do incident and recurrent venous thromboembolism risks truly differ between heterozygous and homozygous Factor V Leiden carriers? A retrospective cohort study. Eur J Intern Med. 2016 May;30:77-81. |
12. Perez Botero J, Spoon DB, Patnaik MS, Ashrani AA, Trousdale RT, Pruthi RK. Incidence of symptomatic venous thromboembolism in patients with hemophilia undergoing joint replacement surgery: a retrospective study. Thromb Res. 2015 Jan;135(1):109-13. |
13. Botero JP, Thanarajasingam G, Warsame R. Capturing and Incorporating Patient-Reported Outcomes into Clinical Trials: Practical Considerations for Clinicians. Curr Oncol Rep. 2016 Oct;18(10):61. |
14. Jatoi A, Grudem ME, Dockter TJ, Block MS, Villasboas JC, Tan A, Deering E, Kasi PM, Mansfield AS, Botero JP, Okuno SH, Smith DR, Fields AP. A proof-of-concept trial of protein kinase C iota inhibition with auranofin for the paclitaxel-induced acute pain syndrome. Support Care Cancer. 2017 Mar;25(3):833-838. PMCID: PMC5269609 |
15. Botero JP, Pruthi RK. Refractory bleeding from intestinal angiodysplasias successfully treated with danazol in three patients with von Willebrand disease. Blood Coagul Fibrinolysis. 2013 Dec;24(8):884-6. |
16. McBane RD 2nd, Wysokinski WE, Le-Rademacher JG, Zemla T, Ashrani A, Tafur A, Perepu U, Anderson D, Gundabolu K, Kuzma C, Perez Botero J, Leon Ferre RA, Henkin S, Lenz CJ, Houghton DE, Vishnu P, Loprinzi CL. Apixaban and dalteparin in active malignancy-associated venous thromboembolism: The ADAM VTE trial. J Thromb Haemost. 2020 Feb;18(2):411-421. |
17. Botero JP, Lee K, Branchford BR, Bray PF, Freson K, Lambert MP, Luo M, Mohan S, Ross JE, Bergmeier W, Di Paola J, ClinGen Platelet Disorder Variant Curation Expert Panel. Glanzmann thrombasthenia: genetic basis and clinical correlates. Haematologica. 2020 Apr;105(4):888-894. PMCID: PMC7109743 |
18. Ross JE, Zhang BM, Lee K, Mohan S, Branchford BR, Bray P, Dugan SN, Freson K, Heller PG, Kahr WHA, Lambert MP, Luchtman-Jones L, Luo M, Perez Botero J, Rondina MT, Ryan G, Westbury S, Bergmeier W, Di Paola J. Specifications of the variant curation guidelines for ITGA2B/ITGB3: ClinGen Platelet Disorder Variant Curation Panel. Blood Adv. 2021 Jan 26;5(2):414-431. PMCID: PMC7839359 |
19. Bauer ME, Arendt K, Beilin Y, Gernsheimer T, Perez Botero J, James AH, Yaghmour E, Toledano RD, Turrentine M, Houle T, MacEachern M, Madden H, Rajasekhar A, Segal S, Wu C, Cooper JP, Landau R, Leffert L. The Society for Obstetric Anesthesia and Perinatology Interdisciplinary Consensus Statement on Neuraxial Procedures in Obstetric Patients With Thrombocytopenia. Anesth Analg. 2021 Jun 01;132(6):1531-1544. |
20. Perez Botero J, Reese JA, George JN, McIntosh JJ. Severe thrombocytopenia and microangiopathic hemolytic anemia in pregnancy: A guide for the consulting hematologist. Am J Hematol. 2021 Dec 01;96(12):1655-1665. PMCID: PMC8616841 |
21. Cameron H, Perez Botero J. Recognition of the unique bleeding pattern and laboratory findings in acquired haemophilia A facilitates prompt treatment of a life-threatening disorder. BMJ Case Rep. 2021 Aug 03;14(8). PMCID: PMC8336148 |
22. Megy K, Downes K, Morel-Kopp MC, Bastida JM, Brooks S, Bury L, Leinoe E, Gomez K, Morgan NV, Othman M, Ouwehand WH, Perez Botero J, Rivera J, Schulze H, Trégouët DA, Freson K. GoldVariants, a resource for sharing rare genetic variants detected in bleeding, thrombotic, and platelet disorders: Communication from the ISTH SSC Subcommittee on Genomics in Thrombosis and Hemostasis. J Thromb Haemost. 2021 Oct;19(10):2612-2617. PMCID: PMC9291976 |
23. Stevens-Haas CL, Livergood MC, Perez Botero J, McIntosh JJ. Peripartum management of deep venous thrombosis in the context of antithrombin deficiency and May-Thurner syndrome. Blood Coagul Fibrinolysis. 2023 Apr 01;34(3):211-214. PMCID: PMC10089933 |
24. Tariq H, Perez Botero J, Higgins RA, Medina EA. Gray Platelet Syndrome Presenting With Pancytopenia, Splenomegaly, and Bone Marrow Fibrosis. Am J Clin Pathol. 2021 Jul 06;156(2):253-258. |
25. Warsame R., Hubbard J., Thompson C.A., Croghan K., Tan A., Fruth B., Perez Botero J., Pachman D., Lafky V., Dispenzieri A., Sloan J. A Novel Case Management System to Address Patient-Identified Concerns in Hematology and Oncology Clinical Pathways Journal of Clinical Pathways . . |
Books, Chapters, and Reviews |
1. Perez Botero J, Wysokinska EM, Ashrani AA. Von Willebrand Disease. The 5-Minute Clinical Consult The 5-Minute Clinical Consult. Twenty-Sixth Edition, 2018. Wolter Kluwer Health. ISBN 9781496374622. . |
2. Sharma R, Perez Botero J, Jobe SM. Congenital Disorders of Platelet Function and Number. Pediatr Clin North Am. 2018 Jun;65(3):561-578. |
3. Perez Botero J, Di Paola J. Diagnostic approach to the patient with a suspected inherited platelet disorder: Who and how to test. J Thromb Haemost. 2021 Sep;19(9):2127-2136. |
4. Sullivan MJ, Palmer EL, Botero JP. ANKRD26-Related Thrombocytopenia and Predisposition to Myeloid Neoplasms. Curr Hematol Malig Rep. 2022 Oct;17(5):105-112. |
5. Sullivan M, Perez Botero J . CD36 immunization causing platelet transfusion refractoriness: narrative review Annals of Blood . Annals Of Blood, 6. doi:10.21037/aob-21-36. |
6. Perez Botero J, Dugan SN, Anderson MW. ANKRD26-Related Thrombocytopenia . In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018.. |
Editorials, Letters to Editor, Other |
1. Perez Botero J, Ho TP, Rodriguez V, Khan SP, Pruthi RK, Patnaik MM. Coagulation abnormalities and haemostatic surgical outcomes in 142 patients with Noonan syndrome. Haemophilia. 2017 May;23(3):e237-e240. |
2. Perez Botero J, Ho TP, Hogan WJ, Kenderian S, Gangat N, Tefferi A, Abraham RS, Nguyen P, Oliveira JL, He R, Chen D, Viswanatha D, Rodriguez V, Khan SP, Patnaik MM. Clinical spectrum and clonal evolution in germline syndromes with predisposition to myeloid neoplasms. Br J Haematol. 2018 Jul;182(1):141-145. |
3. Perez Botero J, Rodriguez V. Primary Lymphedema and Viral Warts in GATA2 Haploinsufficiency. Mayo Clin Proc. 2017 Mar;92(3):482. |
4. Perez Botero J, Patnaik MM. Delayed diagnosis of MYH-9–related disorder and the role of light microscopy in congenital macrothrombocytopenias. Blood. 2016 Apr 14;127(15):1940. |
5. Perez Botero J, Patnaik MM. Fanconi Anemia-Protean Manifestations of Defective DNA Repair. Mayo Clin Proc. 2016 Jun;91(6):824-5. |
6. Perez Botero J, Im R, Chen D, Patnaik MM. Grey platelet syndrome misdiagnosed as ITP. Br J Haematol. 2016 Jun;173(5):662. |
7. Perez Botero J, Pruthi RK, Nichols WL, Ashrani AA, Patnaik MM. von Willebrand disease type1/type 2N compound heterozygotes: diagnostic and management challenges. Br J Haematol. 2017 Mar;176(6):994-997. |
8. Perez Botero J, Oliveira JL, Chen D, Reichard KK, Viswanatha DS, Nguyen PL, Pruthi RK, Majerus J, Gada P, Gangat N, Tefferi A, Patnaik MM. ASXL1 mutated chronic myelomonocytic leukemia in a patient with familial thrombocytopenia secondary to germline mutation in ANKRD26. Blood Cancer J. 2015 May 22;5(5):e315. PMCID: PMC4476020 |
9. Perez J, Lucena E, Hughes M, Lizcano L, Kasper CK. Preimplantation genetic diagnosis--a historical annotation: first PGD baby turns fifteen. Haemophilia. 2011 Jul;17 Suppl 1:18-9. |
10. Partain DK, Botero JP, Shi M, Poterucha JJ, Ashrani AA, Thompson CA. Spur cell anemia in the setting of progressive liver allograft failure. Am J Hematol. 2016 Oct;91(10):1061. |
11. Perez Botero J, Burns D, Thompson CA, Pruthi RK. Successful treatment with thalidomide of a patient with congenital factor V deficiency and factor V inhibitor with recurrent gastrointestinal bleeding from small bowel arteriovenous malformations. Haemophilia. 2013 Jan;19(1):e59-61. |
12. Haddox CL, Carr RM, Abraham RS, Perez Botero J, Rodriguez V, Pardanani A, Patnaik MM. Phenotypic heterogeneity associated with germline <i>GATA2</i> haploinsufficiency: a comprehensive kindred study. Leuk Lymphoma. 2019 Dec;60(13):3282-3286. PMCID: PMC6923578 |
13. Perez Botero J. What to expect when an ITP patient is expecting. Blood. 2023 Jan 05;141(1):3-4. |
Non-Refereed Journal Publications/Original Papers |
1. Perez Botero, J . Diagnostic considerations with inherited platelet disorder testing Medical Laboratory Observer. . |
2. Ross JE, Mohan S, Zhang J, Sullivan MJ, Bury L, Lee K, Futchi I, Frantz A, McDougal D, Perez Botero J, Cattaneo M, Cooper N, Downes K, Gresele P, Keenan C, Lee AI, Megy K, Morange PE, Morgan NV, Schulze H, Zimowski K, Freson K, Lambert MP. Evaluating the clinical validity of genes related to hemostasis and thrombosis using the Clinical Genome Resource gene curation framework. J Thromb Haemost. 2024 Mar;22(3):645-665. PMCID: PMC10922649 |
Database, Video, or Other Research/Clinical Contributions |
1. Perez Botero J, Duarte M, Llinas A. Update in the management of hemophilia – Online Course. Co-author of the module on hematologic perspective of hemophilia and general editor and producer of the entire course’s content. Sponsored by Pfizer Colombia. Material produced in Spanish. . |