CURRICULUM VITAE
Justin L. Grobe PhD
Justin L. Grobe PhD
Professor
Department of Physiology
& Department of Biomedical Engineering;
Butenhoff Family Professor of Cardiovascular Research;
Director, Comprehensive Rodent Metabolic Phenotyping Core;
Vice-Chair, Institutional Animal Care & Use Committee
ORCiD: 0000-0001-9737-0873
Department of Physiology
& Department of Biomedical Engineering;
Butenhoff Family Professor of Cardiovascular Research;
Director, Comprehensive Rodent Metabolic Phenotyping Core;
Vice-Chair, Institutional Animal Care & Use Committee
ORCiD: 0000-0001-9737-0873
OFFICE ADDRESS: |
Health Research Center |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
Phone: 414-955-4981 |
Email: jgrobe@mcw.edu |
EDUCATION: |
08/1997 - 05/2001 BS (Biology) + BA (Chemistry); Mentor: Christopher C. Barney, PhD, Hope College, Holland, MI |
08/2001 - 05/2006 PhD (Pharmacodynamics); Mentor: Michael J. Katovich, PhD, University of Florida, Gainesville, FL |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
05/2006 - 09/2006 Postdoctoral Fellow (laboratory of Mohan K. Raizada, PhD), Department of Physiology & Functional Genomics, College of Medicine, University of Florida, Gainesville, FL |
09/2006 - 06/2010 Postdoctoral Fellow (laboratory of Curt D. Sigmund, PhD), Department of Internal Medicine, Roy J. & Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA |
FACULTY APPOINTMENTS: |
07/2010 - 05/2012 Associate (Instructor equivalent), Department of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA |
06/2012 - 06/2017 Assistant Professor (Tenure Track), Department of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA |
07/2017 - 06/2019 Associate Professor with Tenure, Department of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA |
07/2019 - 06/2023 Associate Professor with Tenure, Departments of Physiology & Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI |
07/2023 - Present Professor with Tenure, Departments of Physiology & Biomedical Engineering, Medical College of Wisconsin |
EDUCATIONAL ADMINISTRATIVE APPOINTMENTS: |
09/2023 - Present Member, Graduate Committee, Biomedical Engineering, Medical College of Wisconsin |
RESEARCH ADMINISTRATIVE APPOINTMENTS: |
07/2019 - Present Director, Comprehensive Rodent Metabolic Phenotyping Core, Medical College of Wisconsin, Milwaukee, WI |
08/2022 - Present Vice-Chair, Institutional Animal Care & Use Committee (IACUC), Medical College of Wisconsin, Milwaukee, WI |
AWARDS AND HONORS: |
2001 Departmental Service Award - Department of Biology, Hope College |
2001 Frank Patterson Memorial Award - Department of Biology, Hope College |
2005 Association for Chemoreception Sciences (AChemS) Conference Travel Award - UF Center for Smell and Taste, University of Florida |
2006 First Place, Oral Presentation (Senior Division), 19th Annual Research Showcase, University of Florida College of Pharmacy |
2007 Merck New Investigator Award, American Heart Association Council on Hypertension |
2007 Clinical Science Young Investigator Award, sponsored by Portland Press, American Physiological Society Cardiovascular Section |
2008 Poster Award, Gordon Research Conference: Angiotensin |
2008 Research Recognition Award, American Physiological Society Neural Control and Autonomic Regulation Section |
2008 Young Investigator Award, Society for Experimental Biology and Medicine |
2008 New Investigator Travel Award, American Heart Association Council on Hypertension |
2008 Caroline tum Suden / Frances A. Hellebrandt Professional Opportunity Award, American Physiological Society |
2009 Carver College of Medicine Health Sciences Research Week Poster Presentation Award, Postdoctoral Fellow Division, University of Iowa |
2011 New Investigator of the Month, International Society of Hypertension |
2012 Elected to "Fellow of the American Heart Association" (FAHA), American Heart Association Council on Hypertension |
2014 Young Scholar Award, American Society of Hypertension |
2014 - 2015 Recognized as among top 10 reviewers for journal, Hypertension (journal) |
2015 Young Investigator Award , American Physiological Society Water & Electrolyte Homeostasis Section |
2015 Harry Goldblatt New Investigator Award, American Heart Association Council on Hypertension |
2016 Office of the Vice President for Research & Economic Development Inventor Award, University of Iowa |
2016 "Forty Under 40" Award, Cedar Rapids / Iowa City area Corridor Business Journal |
2017 Awarded Tenure, University of Iowa |
2017 Arthur C. Guyton Award for Excellence in Integrative Physiology, American Physiology Society |
2017 Office of the Vice President for Research & Economic Development Inventor Award, University of Iowa |
2018 - 2022 Established Investigator Award, American Heart Association |
2018 Office of the Vice President for Research & Economic Development Inventor Award, University of Iowa |
2018 Outstanding Reviewer Award, Experimental Biology and Medicine (journal) |
2019 Awarded Tenure, Medical College of Wisconsin |
2021 MCW Outstanding Medical Student Teacher for 2020-2021 (Physiology), Medical College of Wisconsin |
2021 Elected to Fellow of the American Physiological Society (FAPS), American Physiological Society |
2022 MCW Outstanding Graduate School Educators for 2021-2022 (Physiology), Medical College of Wisconsin |
2022 Mid-Career Award for Research Excellence, American Heart Association Council on Hypertension |
2023 MCW Outstanding Medical Student Teacher for 2022-2023 (Physiology), Medical College of Wisconsin |
2023 MCW Outstanding Graduate School Educators for 2022-2023 (Biostatistics), Medical College of Wisconsin |
2024 - Present Butenhoff Family Professorship in Cardiovascular Research |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
1998 - 2001 Beta Beta Beta Undergraduate Biological Honor Society (Hope College) |
1999 - Present American Heart Association (member 120721042; elected to Fellow (FAHA) in 2012) |
1999 - Present American Physiological Society (member 00033392; elected to Fellow (FAPS) in 2021) |
2000 - 2013 Sigma Xi |
2005 - 2013 Society for Experimental Biology and Medicine |
2011 - 2013 International Society of Hypertension |
2013 - Present American Diabetes Association (member 08344175 / 0520608555) |
2014 - 2018 American Society for Pharmacology and Experimental Therapeutics (member 49382) |
2018 - Present The Obesity Society (member 25073) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorial Board |
01/2012 - 12/2024 Hypertension |
2015 - 2021 Physiological Genomics (Section Editor) |
2018 - Present JAHA: Journal of the American Heart Association (frequent Guest Associate Editor) |
2019 - 2021 Biology of Sex Differences |
Ad-Hoc Reviewer |
2007 - Present Hypertension |
2008 - Present American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology |
2008 - Present Physiological Genomics |
2009 - Present Circulation Research |
2009 - Present Biochemical Pharmacology |
2009 - Present Obesity |
2011 - Present American Journal of Physiology: Heart and Circulatory Physiology |
2011 - Present British Journal of Pharmacology |
2011 - Present Regulatory Peptides |
2011 - Present International Journal of Hypertension |
2011 - Present Cellular Physiology and Biochemistry |
2012 - Present Clinical and Experimental Pharmacology and Physiology |
2012 - Present Journal of Applied Physiology |
2012 - Present Journal of Cardiovascular Pharmacology and Therapeutics |
2012 - Present PLOS ONE |
2013 - Present Acta Physiologica |
2013 - Present Hypertension Research |
2013 - Present Cellular and Molecular Neurobiology |
2013 - Present Experimental Physiology |
2014 - Present Journal of Cardiovascular Pharmacology |
2014 - Present Endocrine |
2014 - Present Yonsei Medical Journal |
2014 - Present Journal of the American Heart Association (JAHA) |
2014 - Present Advances in Pharmacology |
2014 - Present BMC Medical Genetics |
2014 - Present Microcirculation |
2014 - Present Diabetes |
2015 - Present Neuropsychopharmacology |
2015 - Present Journal of Thermal Biology |
2016 - Present Scientific Reports |
2016 - Present American Journal of Physiology: Endocrinology & Metabolism |
2018 - Present Nutrition and Diabetes |
2024 - Present Journal of the American Association of Laboratory Animal Science (JAALAS) |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2000 - 2001 President, Alpha Eta Chapter, Beta Beta Beta Biological Honor Society, Hope College |
2008 - 2010 Member, Trainee Advocacy Committee, American Heart Association / Council on Hypertension |
2010 - 2013 Chair, Trainee Advocacy Committee, American Heart Association / Council on Hypertension |
2011 - 2012 Member, Early Career Task Force, American Heart Association / Council Operations Committee |
2013 - 2023 Member, Nominating Committee, American Heart Association / Council on Hypertension |
2013 Member, Hypertension Summer School Planning Committee, American Heart Association / Council on Hypertension |
2014 - 2017 Vice-Chair, Research Committee, American Heart Association / Midwest Affiliate |
2015 - 2016 Coordinator, Data Diuresis Session, American Physiological Society / Water & Electrolyte Homeostasis Section |
11/2018 Ad hoc reviewer, F10A-R (Fellowships) study section, NIH CSR |
2018 - 2023 Member, Membership & Communications Committee, American Heart Association / Council on Hypertension |
02/2019 Ad hoc reviewer, Hypertension & Microcirculation (HM) study section, NIH CSR |
04/2019 Ad hoc reviewer, Vascular & Hematology AREA (R15) study section, NIH CSR |
2019 - 2023 Member, HTN Fall Specialty Conference Planning Committee, American Heart Association / Council on Hypertension |
02/2020 Ad hoc reviewer, P01 Special Emphasis Panel, NIH CSR |
06/2020 Ad hoc reviewer, Hypertension & Microcirculation (HM) study section, NIH CSR |
2020 - 06/30/2022 Member, Council Operations Committee / Mid-Career Subcommittee, American Heart Association |
2020 - 2022 Member, Water & Electrolyte Homeostasis Section Awards Committee, American Physiological Society |
02/2021 Ad hoc reviewer, P01 Special Emphasis Panel, NIH CSR |
06/2021 Ad hoc reviewer, Translational Research Institute for Space Health (TRISH) Biomedical Research Advances for Space Health (BRASH2101), National Aeronautics and Space Administration (NASA) |
10/2021 Ad hoc reviewer, P01 Special Emphasis Panel, NIH CSR |
01/2022 Ad hoc reviewer, P01 Special Emphasis Panel, NIH CSR |
06/2022 Ad hoc reviewer, POMD study section, NIH CSR |
11/2022 Ad hoc reviewer, Fellowship Clinical 1 (pre- and post-doctoral fellowship), American Heart Association |
11/2023 Ad Hoc Reviewer, Fellowship Clinical 2 (pre- and post-doctoral fellowship), American Heart Association |
INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2023 Ad hoc, Interdisciplinary & International Projects [Spark] review panel, Swiss National Science Foundation (SNSF) |
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
Gordon Research Conference: Angiotensin, Lucca (Barga), Italy, 2014 |
High Blood Pressure Research Council of Australia / Australian Atherosclerosis Society / the Australian Vascular Biology, Hobart (Tazmania), Australia, 2016 |
Angiotensin action within the arcuate nucleus of the hypothalamus in cardiometabolic control, Vasoactive Peptides, Brazil, 10/16/2021 |
National |
Experimental Biology, San Diego, CA, 2008 |
Gordon Research Conference: Angiotensin, Ventura, CA, 2008 |
American Heart Association Council for High Blood Pressure Research, Tucson, AZ, 2008 |
Univ. of Florida, Dept of Physiology & Functional Genomics, Gainesville, FL, 2010 |
American Heart Association Council for High Blood Pressure Research, Orlando, FL, 2011 |
Pennsylvania State University, Dept of Cellular & Molecular Phys, Hershey, PA, 2011 |
University of Kentucky, Graduate Center for Nutritional Sciences, Lexington, KY, 2011 |
Hope College Department of Biology, Holland, MI, 2011 |
American Heart Association Council for High Blood Pressure Research, Washington, DC, 2012 |
Gordon Research Seminar: Angiotensin, Orlando, FL, 2012 |
American Physiological Society NCAR section conference: Autonomic Regulation of Cardiovascular Function in Health and Disease, Omaha, NE, 2012 |
Experimental Biology, Boston, MA, 2013 |
Goldblatt Award Competition, American Heart Association Council for High Blood Pressure Research, New Orleans, LA, 2013 |
American Heart Association Council for High Blood Pressure Research, Hypertension Summer School 2013, Columbia, SC, 2013 |
Univ of North Texas Health Sci Ctr, Dept Integrative Physiol & Anatomy, Fort Worth, TX, 2014 |
Young Scholar Award Lecture, American Society of Hypertension Annual Meeting, New York, NY, 2014 |
International Academy of Cardiovascular Sciences, Omaha, NE, 2015 |
University of Wyoming, Laramie, WY, 2015 |
Goldblatt Award Lecture, American Heart Association Council for High Blood Pressure Research, Washington, DC, 2015 |
Water & Electrolyte Homeostasis Section New Investigator Award, American Physiological Society, Boston, MA, 2015 |
Medical College of Wisconsin, Department of Physiology, Milwaukee, WI, 2016 |
FASEB Summer Research Conference: Neural Mechanisms in Cardiovascular Regulation: Novel Research and Disease Treatment Strategies, Saxtons River, VT, 2016 |
Medical College of Wisconsin, Department of Physiology, Milwaukee, WI, 2018 |
American Heart Association Council on Hypertension, New Orleans, LA, 2019 |
Angiotensin within the hypothalamic arcuate nucleus in cardiometabolic control during obesity, Neural & Behavioral Sciences, Penn State College of Medicine, 2021 |
Cardiometabolic adaptation during obesity: Role of the local renin-angiotensin system within the arcuate nucleus of the hypothalamus, Center for Integrative Cardiovascular and Metabolic Disease, University of Florida, 2021 |
Combining Direct + Indirect Calorimetry to Improve Quantification of Energy Expenditure, Division of Endocrinology Grand Rounds, Beth Israel Deaconess Medical Center / Harvard Medical School, 2022 |
Resting Metabolism: Control by the Brain, and Contributions of the Gut, Department of Physiology and Pharmacology Molecular Medicine (MOME) Seminar Series, University of Toledo, 2022 |
Angiotensin in the Arcuate: Unlocking Neural Mechanisms Integrating Cardiometabolic Control in Health and Disease, Pharmacology Seminar Program, Tulane University, 2022 |
Angiotensin in the Arcuate: Unlocking Neural Mechanisms Integrating Cardiometabolic Control in Health & Disease, American Heart Association Council on Hypertension 2022 Scientific Sessions, San Diego, CA, 2022 |
Cardiometabolic Control by Angiotensin in the Arcuate Nucleus of the Hypothalamus, LSUHSC Cardiovascular Center for Excellence, Louisiana State University Health Science Center, 2024 |
Regional |
Fraternal Order of Eagles' Missouri, Iowa, Nebraska, Kansas and North & South Dakotas (MINK) section annual conference, Omaha, NE, 2016 |
American Diabetes Association Iowa / Nebraska / South Dakota section Donor Dinner, Riverside, IA, 2016 |
Cardiometabolic adaptation during obesity: Role of the local renin-angiotensin system within the arcuate nucleus of the hypothalamus, Departments of Biomedical Sciences & Biological Sciences, Marquette University, 2021 |
Local |
Internal Medicine Research Day, University of Iowa, 2008 |
Department of Pharmacology Seminar, University of Iowa, 2011 |
Division of Nephrology Seminar, University of Iowa, 2011 |
Molecular & Cellular Biology Interdisciplinary Program Seminar, University of Iowa, 2012 |
Department of Biochemistry Seminar, University of Iowa, 2012 |
Department of Pharmacology Seminar, University of Iowa, 2013 |
Obesity Initiative, University of Iowa, 2013 |
University of Iowa MSTP (MD/PhD program) summer seminar series, University of Iowa, 2013 |
Department of Pharmacology Seminar, University of Iowa, 2014 |
40th Anniversary of the François M. Abboud Cardiovascular Research Center, University of Iowa, 2014 |
Biosciences Program Summer Undergraduate Seminar Series, University of Iowa, 2014 |
Obesity Research & Education Initiative, University of Iowa, 2015 |
IT Community Meeting, University of Iowa, 2015 |
Department of Pharmacology Seminar, University of Iowa, 2015 |
Biosciences Program Summer Undergraduate Seminar Series, University of Iowa, 2016 |
Toxicology/EHSRC/Superfund Seminar, University of Iowa, 2017 |
Carl Gisolfi Memorial Lecture, University of Iowa, 2017 |
Obesity Research & Education Initiative, University of Iowa, 2018 |
Vasopressin, copeptin, and GPCR signaling in preeclampsia, Preeclampsia Working Group, Medical College of Wisconsin, 2019 |
Single-nuclear RNAseq in the arcuate nucleus of the hypothalamus deconvolutes the cellular and molecular basis of selective leptin resistance and obesity-associated hypertension, Department of Physiology, Medical College of Wisconsin, 2019 |
Vasopressin/Copeptin and Preeclampsia, Cardiovascular Center Annual Retreat, Medical College of Wisconsin, 2019 |
Cardiometabolic adaptation during obesity: Role of the local renin-angiotensin system within the arcuate nucleus of the hypothalamus, City-Wide Obesity and Metabolic Disease Grand Rounds, Milwaukee, WI, 2020 |
Regulator of G-protein Signaling-2 in Preeclampsia, WHRP Seminar Series, Medical College of Wisconsin, 2020 |
Cardiometabolic adaptation during obesity: Role of the local renin-angiotensin system within the arcuate nucleus of the hypothalamus, Department of Physiology "Friends of MCW Physiology" Seminar Series, Milwaukee, WI, 2021 |
Metabolic adaptation after obesity: Why can’t we lose weight and keep it off?, MSTP program seminar series, 2023 |
Angiotensin AT1R in Agouti-related peptide (AgRP) neurons in the control of resting metabolism, MCW CVC ATVB group seminar series, 2023 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
2019 - Present Member, MSTP Admissions Committee, Medical College of Wisconsin |
2019 - Present Member, Institutional Animal Care & Use Committee (Vice-Chair, 2022-present), Medical College of Wisconsin |
2023 - Present Member, Search Committee; Director of the Neuroscience Research Center, Medical College of Wisconsin |
MCW TEACHING ACTIVITIES: |
Medical Student Education |
2020 - 2022 Lecturer, Medical Physiology (The Microcirculation and the Lymphatic System: Capillary Fluid Exchange, Interstitial Fluid, and Lymph Flow) |
2021 - 2022 Lecturer, Medical Physiology (Overview of Circulation and Hemodynamics, part 2) |
2021 - 2022 Lecturer, Medical Physiology (Overview of Circulation and Hemodynamics, part 1) |
Graduate Student Education |
2020 - 2022 Course Director and Primary Instructor - PHYS 08220: Biostatistics for Health Sciences |
2022 - Present Section Lead and Lecturer - PHYS 08270: Current Concepts in Cardiovascular Biology (Hypertension Section) |
2023 - Present Co-Course Director and Instructor - INDP 16245: Statistics for Basic Sciences |
EXTRAMURAL TEACHING: |
Graduate Student Education |
2011 - 2013 University of Iowa, Facilitator, PCOL:7270 (650:270) - "Principles of Scholarly Integrity" |
2011 - 2017 University of Iowa, Lecturer, PCOL:5137 (071:137) - "Neurotransmitters" |
2012 University of Iowa, Primary Instructor, BISC:5265 (156:265) - "Biosciences Critical Thinking & Communication" |
2012 University of Iowa, Discussion Leader, "Teaching Your Research" |
2015 University of Iowa, Course Director, PCOL:6030 - "Topics in Pharmacology" |
2015 University of Iowa, Lecturer, PCOL:8240 - "Basic Pharmacology for Dental Students" |
2015 - 2018 University of Iowa, Lecturer, TBM:5001 - "Introduction to Translational Biomedicine" |
2015 - 2018 University of Iowa, Course Founder & Director, and Primary Instructor, PCOL:5204 - "Basic Biostatistics & Experimental Design" |
2016 - 2018 University of Iowa, Lecturer, PATH:5260 (069:260) - "Translational Histopathology" |
2019 University of Iowa, Lecturer, MMED:6260 - "Methods for Molecular and Translational Medicine" |
Continuing Medical Education |
2012 University of Iowa, Obesity 2012: Building a Dream Team |
2014 University of Iowa, Maternal-Fetal Medicine Fellows Conference Lecture "Altered pharmacology in pregnancy" |
2015 University of Iowa, Maternal-Fetal Medicine Fellows Conference Lecture "Fluid and electrolyte balance in pregnancy" |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
High School Students |
2020 Olivia Eckes, Medical College of Wisconsin, SUPREMES program |
Undergraduate Students |
2022 Daeleon Brown-Williams, Medical College of Wisconsin, 2022 SPUR fellowship |
2023 - 2024 Jhonatan Pasos-Cortes, Medical College of Wisconsin, One-year externship (visiting student from Colombia); 2024 AHA Hypertension Scientific Sessions Award for Support of Underrepresented Minorities |
2023 Alyssa M. Madison, Medical College of Wisconsin, 2023 SPUR fellowship |
2024 Margaret (Meg) Dorrington, Medical College of Wisconsin, Summer 2024 SPUR fellowship; 2024-2025 academic year PURE program |
2024 Kush Nandani, Medical College of Wisconsin, 2024 ASPIRE fellowship |
Medical Students |
11/2021 - Present Micah P. Wildes, Pathway Advisor, Medical College of Wisconsin, 2022 MSSRP fellowship (T35 HL072483) |
2022 - 2024 Samuel Lawton, Medical College of Wisconsin, 2023 MSSRP fellowship (T35 HL072483); admitted as an "internal candidate" to MCW MSTP program, May 2024 |
Graduate Students |
PhD Students Advised |
2019 - 2023 McKenzie L. Ritter, (Physiology), Medical College of Wisconsin, 2021 MCW Physiology T32 Fellowship (HL007852); 2021-2023 AHA predoctoral fellowship (903246) |
2019 - 2023 Megan (Vande Hei) Opichka, (Physiology), Medical College of Wisconsin, 2021 MCW Physiology T32 Fellowship (HL007852); 2021-2023 American Heart Association Predoctoral Fellowship (826132); 2021 MCW CVC Retreat 2nd place presentation award; 2023 Outstanding Dissertation Award |
2021 - Present Alisha A. Ziegler, (Physiology), Medical College of Wisconsin, Thesis co-mentor with Jeffrey L. Segar, MD; 2022 MCW Physiology T32 Fellowship (HL007852) |
2024 - Present Samuel B.R. Lawton, Medical College of Wisconsin, Admitted as 'internal candidate' to MCW MSTP in May 2024; AHA Hypertension 2024 New Investigator Award from HTN and KCVD councils |
PhD Committees |
2020 - Present Matthew Hadiono (Kirby lab, Microbiology), Medical College of Wisconsin |
2021 - Present Alexis Kazen (Kirby lab, Microbiology), Medical College of Wisconsin |
2021 - Present Fatima Aboulalazm (Kirby lab, Microbiology), Medical College of Wisconsin |
2021 - 2023 Santiago Alvarez (O'Meara lab, Physiology), Medical College of Wisconsin |
2022 - Present Lauren Yunker (Kriegel lab, Physiology), Medical College of Wisconsin |
2022 - 2024 Natalia M. Mathieu (Sigmund lab, Physiology), Medical College of Wisconsin |
2023 - Present Autumn Hamilton (Sigmund lab, Physiology), Medical College of Wisconsin |
2023 - Present Tyler Laib (Kirby lab, Microbiology), Medical College of Wisconsin |
Students Advised |
2023 Jared R. Burks, (Biomedical Engineering), Medical College of Wisconsin |
Postdoctoral Students |
02/01/2019 - 05/03/2021 Vanessa A. De Oliveira, PhD, Medical College of Wisconsin, (Now faculty at UNIFENAS Universidade, Divinopolis, Brazil) |
03/01/2019 - 06/30/2021 Chetan N. Patil, PhD, Medical College of Wisconsin, (Now a Research Scientist at MCW / Pediatric Nephrology) |
08/01/2019 - 10/01/2023 Kirthikaa Balapattabi, PhD, Medical College of Wisconsin, 2019 APS NCARnation finalist; 2021 NIH Outstanding Scholars in Neuroscience Award (OSNAP); 2021-2022 American Physiological Society Postdoctoral Fellowship; 2021 NCW Office of Postdoctoral Education Postdoc Professional Developmental Award; 2021-2023 AHA Postdoctoral Fellowship (898067) |
Clinical/Research Fellows |
07/2022 - 06/2024 Colin M.L. Burnett, MD, MS, (Cardiology / Electrophysiology), Medical College of Wisconsin |
07/2023 - 06/2025 Benjamin Araya, DO, (Pediatrics / Neonatology), Medical College of Wisconsin |
Faculty |
2020 - Present Lisa L. Morselli, MD, PhD, (Internal Medicine / Endocrinology), Medical College of Wisconsin |
07/2024 - Present Colin M.L. Burnett, MD, MS, (Cardiology / Electrophysiology), Medical College of Wisconsin |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
High School Students |
2014 Whitney Li, University of Iowa, 2014 Secondary Student Training Program (SSTP) fellowship |
2014 - 2015 Jonathan Ni, University of Iowa |
2015 Emily G. Suen, University of Iowa, 2015 Secondary Student Training Program (SSTP) fellowship |
2015 Sriram Sugumaran, University of Iowa |
2016 Mengda (Amanda) Liu, University of Iowa, 2016 Secondary Student Training Program (SSTP) fellowship |
2017 Lily Jiaqi Cao, University of Iowa, 2017 Secondary Student Training Program (SSTP) fellowship |
2017 Andrew Usachev, University of Iowa |
Undergraduate Students |
2010 - 2012 Beth A. Buehrer, University of Iowa, 2010-2011 Iowa Center for Research by Undergraduates (ICRU) academic year fellowship; 2011 Research at the Capitol Day 2011 (UI representative); 2011 AHA summer research fellowship; 2011-2012 Iowa Center for Research by Undergraduates (ICRU) academic year fellowship |
2011 - 2014 Benjamin J. Weidemann, University of Iowa, 2012 AHA summer fellowship; 2012-2013 Iowa Center for Research by Undergraduates (ICRU) academic year fellowship; 2013 Iowa Center for Research by Undergraduates (ICRU) travel award; 2013 American Physiological Society Undergraduate Research Excellence Fellowship award (UGREF); 2013 University of Iowa "SUMR" pre-MD/PhD program summer research fellowship; 2013 University of Iowa Department of Chemistry Undergraduate Award; 2013-2014 Iowa Center for Research by Undergraduates (ICRU) academic year fellowship; 2014 Research at the Capitol Day UI representative; 2014 American Physiological Society Undergraduate David S. Bruce award; 2014 University of Iowa Department of Pharmacology Amanda Hope Skolnick Memorial Award; 2014 University of Iowa Department of Chemistry Merck Index Award |
2012 - 2014 Susan Voong, University of Iowa, American Physiological Society Undergraduate Summer Research Fellowship award (UGSRF) |
2012 Aaron F. Sigmund, University of Iowa |
2014 - 2016 Kevin V. Tobin, University of Iowa |
2014 - 2017 Danny W. Linggonegoro, University of Iowa, 2015 AHA summer fellowship; 2015-2016 Iowa Center for Research by Undergraduate academic year fellowship; 2016 American Diabetes Association Minority Undergraduate Internship #1-16-MUI-06; 2016 Research at the Capitol Day representative; 2016 University of Iowa Center for Research by Undergraduate Excellence in Undergraduate Research Award; 2016 American Physiological Society Undergraduate Research Excellence Fellowship award (UGREF) |
2014 Fabiola I. Morales, University of Iowa, 2014 University of Iowa Summer Research Opportunities Program (SROP) fellowship |
2014 - 2016 Erica R. Cole, University of Iowa, 2015 Iowa Center for Research by Undergraduates (ICRU) travel award; 2015-2016 Iowa Center for Research by Undergraduates (ICRU) academic year fellowship |
2016 Marquis R. Smith, University of Iowa, 2016 Summer Research Opportunities Program (SROP) fellowship |
2016 - 2019 Shao Yang Zhang, University of Iowa, 2017 American Physiological Society Undergraduate Summer Research Fellowship (UGSRF); 2017-2018 University of Iowa Academic Year Iowa Center for Research by Undergraduates (ICRU) Research Fellowship; 2018 Experimental Biology Barbara A. Horowitz & John M. Horowitz Undergraduate Research Award; 2018 American Physiological Society Undergraduate Research Excellence Fellowship (UGREF); 2018-2019 University of Iowa Academic Year Iowa Center for Research by Undergraduates (ICRU) Research Fellowship; 2019 APS Barbara A. and John
M. Horwitz Undergraduate Abstract Award at EB 2019 |
2016 Alyssa T. Ray, University of Iowa, 2016 University of Iowa Center for Research by Undergraduate (ICRU) summer fellowship |
2016 - 2018 Jairui Xue, University of Iowa |
2016 Phillip Witcher, University of Iowa, 2016 University of Iowa "SUMR" pre-MD/PhD program summer fellowship |
2017 Casee Meincke, University of Iowa, 2017 University of Iowa Center for Research by Undergraduates (ICRU) summer fellowship |
2018 Kevin Chen, University of Iowa, 2018 American Physiological Society Summer Undergraduate Research Fellowship (UGSRF) |
2018 - 2019 Caitlyn E. Owens, University of Iowa |
Medical Students |
2010 Scott G. Westphal, University of Iowa |
2011 Rick B. Siel, Jr., University of Iowa, 2011 Medical Student Research Program summer fellowship; 2011 "Edward Heath Award" for outstanding Medical Student research |
2012 - 2016 Matthew D. Folchert, University of Iowa, Research Distinction Track (RDT); 2012 Medical Student Research Program summer fellowship |
2013 - 2016 James Y. Min, University of Iowa, Research Distinction Track (RDT); 2013 Medical Student Research Program 2013 summer fellowship |
2015 - 2019 Ruth A. Riedl, University of Iowa, Medical Student Research Distinction Track (RDT); 2015 University of Iowa "SUMR" pre-MD/PhD program summer fellowship; 2016 Medical Student Research Program summer fellowship; 2016 Outstanding Presentation in Pharmacological Research Award; 2017 Medical Student Research Program summer fellowship; 2017 Outstanding Presentation in Pharmacological Research Award; Research Distinction Track |
2017 - 2019 Kendra L. Frey, University of Iowa, 2017 Medical Student Research Program summer fellowship; Research Distinction Track |
2018 - 2019 John (Jackson) W. Walsh, University of Iowa, 2018 Medical Student Research Program summer fellowship; Research Distinction Track |
Graduate Students |
PhD Students Advised |
2012 - 2015 Nicole K. Littlejohn, Tissue-specific Roles for the Renin-Angiotensin System in Cardiovascular and Metabolic Regulation, University of Iowa, Pharmacology, 2013 AHA Council on Hypertension New Investigator Travel Award; 2014-2015 AHA Predoctoral Fellowship #14PRE18330015; 2016 Gordon Research Conference on Angiotensin invited speaker |
2013 - 2019 Jeremy A. Sandgren, Vasopressin in Preeclampsia, University of Iowa, Pharmacology / Medical Scientist Training Program, Medical Scientist Training Program (MSTP) MD/PhD; 2014-2015 Pharmacological Sciences Predoctoral Fellowship T32 GM067795; 2015 Experimental Biology WEH Data Diuresis invited speaker; 2016-2018 AHA Predoctoral Fellowship #16PRE30980043; 2016-2017 University of Iowa Department of Pharmacology Ranbir K. Bhatnagar Scholar Award; 2017 Experimental Biology Water & Electrolyte Homeostasis Section Graduate Student Oral Competition (1st Place) |
2013 - 2016 Kristin E. Claflin (Yin), The Brain Renin-Angiotensin System in Metabolic and Cardiovascular Regulation, University of Iowa, Pharmacology, 2014-2016 AHA Predoctoral Fellowship #14PRE20380401; 2016 Gordon Research Conference on Angiotensin invited speaker |
2015 - 2018 Katherine J. Perschbacher, Reduced Placental Expression of Regulator of G Protein Signaling-2 (RGS2) in Preeclampsia: Association, Consequence, and Cause, University of Iowa, Molecular & Cellular Biology, Molecular & Cellular Biology (2015-2018). 2017 University of Iowa Graduate College Post-comprehensive Research Fellowship; 2017 Molecular & Cellular Biology Graduate Program travel award; 2017-2019 AHA Predoctoral Fellowship #17PRE33660633; 2017-2018 University of Iowa Department of Pharmacology Ranbir K. Bhatnagar Scholar Award; 2017 Finalist / Honorable Mention, University of Iowa Graduate College "3 minute Thesis" Oral Presentation Competition; 2018 Experimental Biology Water & Electrolyte Homeostasis Section Data Diuresis invited speaker |
2016 - 2019 Sarah A. Sapouckey, The Renin-Angiotensin System in Metabolism and Development, University of Iowa, Molecular & Cellular Biology, 2017 Molecular & Cellular Biology Graduate Program travel award; 2018 Gordon Research Conference on Angiotensin invited speaker; 2018-2020 AHA Predoctoral Fellowship #18PRE33960377 |
PhD Committees |
2012 Aaron Mickle, University of Iowa |
2012 Kyle Flippo, University of Iowa |
2013 Jacqueline Reilly, University of Iowa |
2014 Balyssa Bell, University of Iowa |
2015 Rachel Minerath, University of Iowa |
2015 Magdalene Ameka, University of Iowa |
2016 Yujia (Jennie) Liu, University of Iowa |
2016 Lucas Bon Durant, University of Iowa |
2016 Samantha N. Atkinson, University of Iowa |
2016 Maria F. Noterman, University of Iowa |
2016 Alexander (Sasha) Tereshchenko, University of Iowa |
2016 Dylan Todd, University of Iowa |
2016 Rebecca K. Autenried, University of Iowa |
2017 Gail I. Harmata, University of Iowa |
2017 Serena (Banu) Gumusoglu, University of Iowa |
2017 Frida A. Teran, University of Iowa |
2018 Rachel Schroeder, University of Iowa |
2018 Thomas Pak, University of Iowa |
2018 Grant Walters, University of Iowa |
2019 Mackenzie M. Spicer, University of Iowa |
2021 - Present Aaron A. Jones (Arble lab, Biological Sciences), Marquette University |
MS Committees |
2014 Ko-Ting Lu, University of Iowa |
2015 Hannah Van Beek, University of Iowa |
Postdoctoral Students |
01/01/2017 - 06/30/2019 Guorui Deng, PhD, University of Iowa, 2017-2019 AHA Strategically Focused Research Network H3 Fellow; 2018 Gordon Research Conference on Angiotensin outstanding poster presentation award; 2018 FOEDRC Research Day outstanding poster presentation award; April 2019 - Mar 2021 American Heart Association Postdoctoral Fellowship (19POST34380239); 2019 Trainee Research Excellence Award sponsored by Data Sciences International (DSI) from the American Physiological Society Physiological ‘Omics research group (Now postdoc at University of Iowa) |
Clinical/Research Fellows |
2012 - 2019 Colin M.L. Burnett, MD, MS, University of Iowa, 2012 Medical Student Research Program summer fellowship; 2012 Outstanding Presentation in Pharmacological Research Award; 2013 Medical Student Research Program summer fellowship; 2013 Outstanding Presentation in Pharmacological Research Award |
07/01/2017 - 06/30/2019 Lisa L. Morselli, MD, PhD, University of Iowa, Endocrinology Fellow. 2017-2019 University of Iowa Multidisciplinary Lung Research Career Development Program Fellowship # T32 HL007638 |
Faculty |
2022 - Present Sabrina Scroggins, PhD, External K01/KL2 advisory committee member, University of Minnesota, Duluth |
COMMUNITY SERVICE ACTIVITIES: |
1997 - 1998 Microbiology teaching laboratory preparation, Hope College Department of Biology, Holland, MI |
1998 - 2002 Webmaster, Hope College Department of Biology, Holland, MI |
2001 - 2002 Department Representative, University of Florida Graduate Student Council, Gainesville, FL |
2001 - 2004 Website design team, University of Florida Department of Pharmacodynamics, Gainesville, FL |
2005 - 2006 Congregational Council (Secretary, 2006), University Lutheran Church, Gainesville, FL |
2015 University of Iowa / Fraternal Order of Eagles' Diabetes Research Center representative to, National FOE Convention, Milwaukee, WI |
2015 Community science outreach, Walcott, IA Lion's Club |
2016 Represented Diabetes Research Center, and presented ongoing research to, Missouri / Iowa / Nebraska / Kansas / Dakotas chapter of the Fraternal Order of Eagles' (FOE MINK), Omaha, NE |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Burnatowska-Hledin M, Zeneberg A, roulo A, Grobe JL, Zhao P, Lelkes PI, Clare P, Barney C. Expression of VACM-1 protein in cultured rat adrenal endothelial cells is linked to the cell cycle, Endothelium. 2001;8(1):49-63. PMID:11409851. |
2. Barney CC, Kurylo DM, Grobe JL. Thermal dehydration-induced thirst in lithium-treated rats, Pharmacol Biochem Behav. 2003 May;75(2):341-347. PMID:12873625. |
3. Grobe JL, Katovich M, Rowland N. Role of angiotensin II in the subfornical organ in the pharmacological actions of ethanol, Alcohol and Alcoholism. 2004 September;39(5):410-417. PMID:15289207. |
4. Huentelman MJ, Grobe JL, Vazquez J, Stewart JM, Mecca AP, Katovich MJ, Ferrario CM, Raizada MK. Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats, Exp Physiol. 2005 September;90(5):783-790. PMID:16049057. |
5. Grobe JL, Katovich MJ. Alterations in aortic vascular reactivity to angiotensin 1-7 in 17-beta-estradiol-treated female SD rats, Regul Pept. 2006 January 15;133(1-3):62-67. PMID:16219374. |
6. Grobe JL, Mecca AP, Mao H, Katovich MJ. Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension, Am J Physiol Heart Circ Physiol. 2006 June;290(6):H2417-H2423. PMID:16415071. |
7. Li H, Gao Y, Grobe JL, Raizada MK, Katovich MJ, Sumners C. Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor, Am J Physiol Heart Circ Physiol. 2007 February;2992(2):H727-H735. PMID:17085538. |
8. Grobe JL, Mecca AP, Lingis M, Shenoy V, Bolton TA, Machado JM, Speth RC, Raizada MK, Katovich MJ. Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7), Am J Physiol Heart Circ Physiol. 2007 February;292(2):H736-H742. PMID:17098828. |
9. Grobe JL, Der Sarkissian S, Stewart JM, Meszaros JG, Raizada MK, Katovich MJ. ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts, Clin Sci (Lond). 2007 October;113(8):357-364. PMID:17600530. |
10. Der Sarkissian S, Grobe JL, Yuan L, Narielwala DR, Walter GA, Katovich MJ, Raizada MK. Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology, Hypertension. 2008 March;51(3):712-718. PMID:18250366. PMCID: PMC Journal - In Process. |
11. Grobe JL, Xu D, Sigmund CD. An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy, Physiology (Bethesda). 2008 August;23:187-193. PMID:18697992. PMCID: 2538674. |
12. Shenov V, Grobe JL, Qi Y, Ferreira AJ, Fraga-Silva RA, Collamat G, Bruce E, Katovich MJ. 17beta-Estradiol modulates local cardiac renin-angiotensin system to prevent cardiac remodeling in the DOCA-salt model of hypertension in rats, Peptides. 2009 December;30(12):2309-2315. PMID:19747516. PMCID: PMC Journal - In Process. |
13. Xu D, Borges GR, Grobe JL, Pelham CJ, Yang B, Sigmund CD. Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin, Hypertension. 2009 December;54(6):1240-1247. PMID:19822797. PMCID: 2783841. (Editoral Commentary Precedes Paper; 54(6):1216-1217, 2009) |
14. Grobe JL, Grobe CL, Beltz TG, Westphal SG, Morgan DA, Xu D, de Lange WJ, Li H, Sakai K, Thedens DR, Cassis LA, Rahmouni K, Mark AL, Johnson AK, Sigmund CD. The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance, Cell Metabolism. 2010 November 3;12(5):431-442. PMID:21035755. PMCID: 2994017. |
15. Grobe JL, Dickson ME, Park S, Davis DR, Born EJ, Sigmund CD. Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice, Hypertension. 2010 November;56(5):981-987. PMID:20823378. PMCID: 2959143. |
16. Xu D, Borges GR, Davis DR, Agassandian K, Sequeira Lopez ML, Gomez RA, Cassell MD, Grobe JL, Sigmund CD. Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism, Physiol Genomics. 2011 March 29;43(6):286-294. PMID:21189370. PMCID: 3068515. |
17. Grobe JL, Buehrer BA, Hilzendeger AM, Liu X, Davis DR, Xu D, Sigmund CD. Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice, Hypertension. 2011 March;57[Part 2}(3):600-607. PMID:21263123. PMCID: 3144490. |
18. Li H, Weatherford ET, Davis DR, Keen HL, Grobe JL, Daugherty A, Cassis LA, Allen AM, Sigmund CD. Renal proximal tubule angiotensin AT1A receptors regulate blood pressure, Am J Physiol Regul Integr Comp Physiol. 2011 October;301(4):R1067-R1077. PMID:21753145. PMCID: 3197336. |
19. Hilzendeger AM, Morgan DA, Brooks L, Dellsperger D, Liu X, Grobe JL, Rahmouni K, Sigmund CD, Mark AL. A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity, Am J Physiol Heart Circ Physiol. 2012 July 15;303(2):H197-H206. PMID:22610169. PMCID: 3404702. |
20. Pelham CJ, Ketsawatsomkron P, Groh S, Grobe JL, de Lange WJ, Ibeawuchi S-RC, Keen HL, Weatherford ET, Faraci FF, Sigmund CD. Cullin-3 Regulates Vascular Smooth Muscle Function and Arterial Blood Pressure via PPARγ and RhoA/Rho-Kinase, Cell Metab. 2012 October 3;16(4):462-472. PMID:23040068. PMCID: 3474846. |
21. Ketsawatsomkron P, Lorca RA, Keen HL, Weatherford ET, Liu X, Pelham Cj, Grobe JL, Faraci FM, England SK, Sigmund CD. PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity, Circ Res. 2012 November 9;111(11):1446-1458. PMID:22962432. PMCID: 3494760. |
22. Grobe JL, Rahmouni K, Liu X, Sigmund CD. Metabolic rate regulation by the renin-angiotensin system: brain vs. body, Pflugers Arch - European J of Physiology. 2013 January;465(1):167-175. PMID:22491893. PMCID: 3569511. |
23. Hilzendeger AM, Cassell MD, Davis DR, Stauss HM, Mark AL, Grobe JL, Sigmund CD. Angiotensin Type 1a Receptors in the Subfornical Organ Are Required for Deoxycorticosterone Acetate-Salt Hypertension, Hypertension. 2013 March 6;61(3):716-722. PMID:23266541. PMCID: 3573251. |
24. Littlejohn NK, Siel Jr. RB, Ketsawatsomkron P, Pelham CJ, Pearson NA, Hilzendeger AM, Buehrer BA, Weidemann BJ, Li H, Davis DR, Thompson AP, Liu X, Cassell MD, Sigmund CD, Grobe JL. Hypertension in Mice with Transgenic Activation of the Brain Renin-Angiotensin System is Vasopressin-Dependent, Am J Physiol: Regul Integr Comp Physiol. 2013 May 15;304(10):R818-R828. PMID:23535460. PMCID: 3652167. |
25. Burnett CM, Grobe JL. Direct calorimetry identifies deficiencies in respirometry for the determination of resting metabolic rate in C57Bl/6 and FVB mice, Am J Physiol: Endocrinol Metab. 2013 October 1;305(7):E916-E924. PMID:23964071. PMCID: 3798702. |
26. Li W, Peng H, Mehaffey Ep, Kimball CD, Grobe JL, van Gool JM, Sullivan MN, Earley S, Danser AH, Ichihara A, Feng Y. Neuron-Specific (Pro)renin Receptor Knockout Prevents the Development of Salt-Sensitive Hypertension, Hypertension. 2013;63(2):316-323. PMID:24246383. PMCID: 3947277. |
27. Carrillo-Supulveda MA, Keen HL, Davis DR, Grobe JL, Sigmund CD. Role of vascular smooth muscle PPARγ in regulating AT1 receptor signaling and angiotensin II-dependent hypertension, PLoS One. 2014 April 14;9(8):e103786. PMID:25122005. PMCID: 4133177. |
28. Coble JP, Cassell MD, Davis DR, Grobe JL, Sigmund CD. Activation of the renin-angiotensin system, specifically in the subfornical organ is sufficient to induce fluid intake, Am J Physiol Regul Integr Comp Physiol. 2014 April 15;307(4):R376-R386. PMID:24965793. PMCID: 4137154. |
29. Coble JP, Johnson RF, Cassell MD, Johnson AK, Grobe JL, Sigmund CD. Activity of protein kinase C-α within the subfornical organ is necessary for fluid intake in response to brain angiotensin, Hypertension. 2014 July;64(1):141-148. PMID:24777977. PMCID: 4057298. |
30. Shi P, Grobe JL, Desland FA, Zhou G, Shen XZ, Shan Z, Liu M, Raizada MK, Sumners C. Direct pro-inflammatory effects of prorenin on microglia, PLoS One. 2014 October 10;9(10):e92937. PMID:25302502. PMCID: 4193744. |
31. Santillan MK, Santillan DA, Scroggins SM, Min JY, Sandgren JA, Pearson NA, Leslie KK, Hunter SK, Zamba GK, Gibson-Corley KN, Grobe JL. Vasopressin in Preeclampsia: A Novel Very-Early Human Pregnancy Biomarker and Clinically-Relevant Mouse Model, Hypertension. 2014 October;64(4):852-859. PMID:25001273. PMCID: 4162750. |
32. Ye Y, Sun Z, Guo A, Song LS, Grobe JL, Chen S. Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia., Cell Signal. 2014 November;26(11):2514-2520. PMID:25093805. PMCID: 4160384. |
33. Burnett CM, Grobe JL. Dietary effects on resting metabolic rate in C57BL/6 mice are differentially detected by indirect (O2/CO2 respirometry) and direct calorimetry, Molecular Metabolism. 2014;3:460-464. PMID:24944905. PMCID: 4060218. |
34. Fink BD, Herlein JA, Guo DF, Kulkarni C, Weidemann BJ, Yu L, Grobe JL, Rahmouni K, Kerns RJ, Sigmund CD. A mitochondrial-targeted coenzyme q analog prevents weight gain and ameliorates hepatic dysfunction in high-fat-fed mice, J Pharmacol Exp Ther. 2014 December;351(3):699-708. PMID:25301169. PMCID: 4244581. |
35. Santillan MK, Pelham CJ, Ketsawatsomkron P, Santillan DA, Davis DR, Devor EJ, Gibson-Corley KN, Scroggins SM, Grobe JL, Yang B, Hunter SK, Sigmund CD. Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes., Physiological reports. 2015 January 19;3(1):e12257. PMID:25602015. PMCID: 4387753. |
36. Jo F, Jo H, Hilzendeger AM, Thompson AP, Cassell MD, Rutkowski DT, Davisson RL, Grobe JL, Sigmund CD. Brain endoplasmic reticulum stress mechanistically distinguishes the saline-intake and hypertensive response to deoxycorticosterone acetate-salt., Hypertension (Dallas, Tex. : 1979). 2015 June 1;65(6):1341-8. PMID:25895586. PMCID: 4433403. |
37. Weidemann BJ, Voong S, Morales-Santiago FI, Kahn MZ, Ni J, Littlejohn NK, Claflin KE, Burnett CM, Pearson NA, Lutter ML, Grobe JL. Dietary Sodium Suppresses Digestive Efficiency via the Renin-Angiotensin System, Scientific Reports. 2015 June 11;5:11123. PMID:26068176. PMCID: 4464075. |
38. Bahr SM, Weidemann BJ, Castro AN, Walsh JW, deLeon O, Burnett CM, Pearson NA, Murry DJ, Grobe JL, Kirby JR. Risperidone-induced weight gain is mediated through shifts in the gut microbiome and suppression of energy expenditure., EBioMedicine. 2015 November 1;2(11):1725-34. PMID:26870798. PMCID: 4740326. |
39. Barney CC, Schanhals EM, Grobe JL, Andresen BT, Traver M. Heat acclimation and thirst in rats, Physiological reports. 2015 December 1;3(12):e12642. PMID:26702076. PMCID: 4760436. |
40. Ketsawatsomkron P, Keen HL, Davis DR, Lu KT, Stump M, De Silva TM, Hilzendeger AM, Grobe JL, Faraci FM, Sigmund CD. Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension., Hypertension (Dallas, Tex. : 1979). 2016 January 1;67(1):214-22. PMID:26597823. PMCID: 4679422. |
41. Guo DF, Cui H, Zhang Q, Morgan DA, Thedens DR, Nishimura D, Grobe JL, Sheffield VC, Rahmouni K. The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane., PLoS genetics. 2016 February 29;12(2):e1005890. PMID:26926121. PMCID: 4771807. |
42. Muta K, Morgan DA, Grobe JL, Sigmund CD, Rahmouni K. mTORC1 Signaling Contributes to Drinking But Not Blood Pressure Responses to Brain Angiotensin II., Endocrinology. 2016 August 1;157(8):3140-8. PMID:27254006. PMCID: 4967111. |
43. Littlejohn NK, Keen HL, Weidemann BJ, Claflin KE, Tobin KV, Markan KR, Park S, Naber MC, Gourronc FA, Pearson NA, Liu X, Morgan DA, Klingelhutz AJ, Potthoff MJ, Rahmouni K, Sigmund CD, Grobe JL. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor., Cell reports. 2016 August 9;16(6):1548-60. PMID:27477281. PMCID: 4981564. |
44. Boi SK, Buchta CM, Pearson NA, Francis MB, Meyerholz DK, Grobe JL, Norian LA. Obesity alters immune and metabolic profiles: New insight from obese-resistant mice on high-fat diet., Obesity (Silver Spring, Md.). 2016 October 1;24(10):2140-9. PMID:27515998. PMCID: 5039085. |
45. Shinohara K, Liu X, Morgan DA, Davis DR, Sequeira-Lopez ML, Cassell MD, Grobe JL, Rahmouni K, Sigmund CD. Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension., Hypertension (Dallas, Tex. : 1979). 2016 December 1;68(6):1385-1392. PMID:27754863. PMCID: 5159235. |
46. Claflin KE, Sandgren JA, Lambertz AM, Weidemann BJ, Littlejohn NK, Burnett CM, Pearson NA, Morgan DA, Gibson-Corley KN, Rahmouni K, Grobe JL. Angiotensin AT1A receptors on leptin receptor-expressing cells control resting metabolism, The Journal of Clinical Investigation. 2017 April 3;127(4):1414-1424. PMID:28263184. PMCID: 5373887. |
47. Agassandian K, Grobe JL, Liu X, Agassandrian M, Thompson AP, Sigmund CD, Cassell MD. Evidence for intraventricular secretion of angiotensinogen and angiotensin by the subfornical organ using transgenic mice, Am J Physiol Regul Integr Comp Physiol. 2017;312(6):R973-R981. PMID:28490451. PMCID: 5495920. |
48. Srisai D, Yin TC, Lee AA, Rouault AAJ, Pearson NA, Grobe JL, Sebag JA. MRAP2 regulates ghrelin receptor signaling and hunger sensing., Nature communications. 2017 September 28;8(1):713. PMID:28959025. PMCID: 5620068. |
49. Shinohara K, Nakagawa P, Gomez J, Morgan DA, Littlejohn NK, Folchert MD, Weidemann BJ, Liu X, Walsh SA, Ponto LL, Rahmouni K, Grobe JL, Sigmund CD. Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism., Hypertension (Dallas, Tex. : 1979). 2017 November 1;70(5):990-997. PMID:28874461. PMCID: 5679092. |
50. Sandgren JA, Linggonegoro DW, Zhang SY, Sapouckey SA, Claflin KE, Pearson NA, Leidinger MR, Pierce GL, Santillan MK, Gibson-Corley KN, Sigmund CD, Grobe JL. Angiotensin AT1A Receptors Expressed in Vasopressin-Producing Cells of the Supraoptic Nucleus Contribute to the Osmotic Control of Vasopressin., American journal of physiology. Regulatory, integrative and comparative physiology. 2018 January 24;314(6):R770-R780. PMID:29364700. PMCID: PMC6032302. |
51. Scroggins SM, Santillan DA, Lund JM, Sandgren JA, Krotz LK, Hamilton WS, Devor EJ, Davis HA, Pierce GL, Gibson-Corley KN, Sigmund CD, Grobe JL, Santillan MK. Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia., Clinical science (London, England : 1979). 2018 February 14;132(3):419-436. PMID:29371289. PMCID: PMC5947858. |
52. Sandgren JA, Deng G, Linggonegoro DW, Scroggins SM, Perschbacher KJ, Nair AR, Nishimura TE, Zhang SY, Agbor LN, Wu J, Keen HL, Naber MC, Pearson NA, Zimmerman KA, Weiss RM, Bowdler NC, Usachev YM, Santillan DA, Potthoff MJ, Pierce GL, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL. Arginine Vasopressin Infusion is Sufficient to Model Clinical Features of Preeclampsia in Mice, JCI Insight. 2018 October 4;3(19):99403. PMID:30282823. PMCID: PMC6237463. |
53. Ameka M, Markan KR, Morgan DA, BonDurant LD, Idiga SO, Naber MC, Zingman LV, Grobe JL, Rahmouni K, Potthoff MJ. Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure, Scientific Reports. 2019 January 24;9(1):630. PMID:30679672. PMCID: PMC6345819. |
54. Soto JE, Burnett CM, Abel ED, Grobe JL. Comparison of The Effects of High Fat Diet on Energy Flux in Mice Using Two Multiplexed Metabolic Phenotyping Systems, Obesity (Silver Spring). 2019 May;27(5):793-802. PMID: 30938081. PMCID: PMC6478533. |
55. Saito K, Davis KC, Morgan DA, Toth BA, Jiang J, Singh U, Berglund ED, Grobe JL, Rahmouni K, Cui H. Celastrol Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions. Diabetes. 2019 Jun;68(6):1210-1220. PMID: 30894367. PMCID: PMC6610022. |
56. Nair AR, Silva SD Jr, Agbor LN, Wu J, Nakagawa P, Mukohda M, Lu KT, Sandgren JA, Pierce GL, Santillan MK, Grobe JL, Sigmund CD. Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Protects From Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born From Pregnancies Complicated by Hypertension. Hypertension. 2019 Jul;74(1):173-183. PMID: 31104564. PMCID: PMC6561821. |
57. Guo DF, Lin Z, Wu Y, Searby C, Thedens DR, Richerson GB, Usachev YM, Grobe JL, Sheffield VC, Rahmouni K. The BBSome in POMC and AgRP Neurons Is Necessary for Body Weight Regulation and Sorting of Metabolic Receptors. Diabetes. 2019 Aug;68(8):1591-1603. PMID: 31127052. PMCID: PMC6692817. |
58. Perschbacher KJ, Deng G, Sandgren JA, Walsh JW, Witcher PC, Sapouckey SA, Owens CE, Zhang SY, Scroggins SM, Pearson NA, Devor EJ, Sebag JA, Pierce GL, Fisher RA, Kwitek AE, Santillan DA, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL. Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice. Hypertension. 2020 Feb;75(2):569-579. PMCID: PMC7027931 |
59. Segar JL, Grobe CC, Grobe JL. Fetal storage of osmotically inactive sodium. Am J Physiol Regul Integr Comp Physiol. 2020 Mar 01;318(3):R512-R514. PMCID: PMC7099460 |
60. Sapouckey SA, Morselli LL, Deng G, Patil CN, Balapattabi K, Oliveira V, Claflin KE, Gomez J, Pearson NA, Potthoff MJ, Gibson-Corley KN, Sigmund CD, Grobe JL. Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or agouti-related peptide. Am J Physiol Regul Integr Comp Physiol. 2020 May 01;318(5):R855-R869. PMCID: PMC7272763 |
61. Lueschow SR, Kern SL, Gong H, Grobe JL, Segar JL, Carlson SJ, McElroy SJ. Feeding Formula Eliminates the Necessity of Bacterial Dysbiosis and Induces Inflammation and Injury in the Paneth Cell Disruption Murine NEC Model in an Osmolality-Dependent Manner. Nutrients. 2020 Mar 26;12(4). PMCID: PMC7230818 |
62. Wu J, Agbor LN, Fang S, Mukohda M, Nair AR, Nakagawa P, Sharma A, Morgan DA, Grobe JL, Rahmouni K, Weiss RM, McCormick JA, Sigmund CD. Failure to vasodilate in response to salt loading blunts renal blood flow and causes salt-sensitive hypertension. Cardiovasc Res. 2021 Jan 01;117(1):308-319. PMCID: PMC7797211 |
63. Deng G, Morselli LL, Wagner VA, Balapattabi K, Sapouckey SA, Knudtson KL, Rahmouni K, Cui H, Sigmund CD, Kwitek AE, Grobe JL. Single-Nucleus RNA Sequencing of the Hypothalamic Arcuate Nucleus of C57BL/6J Mice After Prolonged Diet-Induced Obesity. Hypertension. 2020 Aug;76(2):589-597. PMCID: PMC7347451 |
64. Nakagawa P, Nair AR, Agbor LN, Gomez J, Wu J, Zhang SY, Lu KT, Morgan DA, Rahmouni K, Grobe JL, Sigmund CD. Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage. Hypertension. 2020 Aug;76(2):468-477. PMCID: PMC7347438 |
65. Ono-Moore KD, Rutkowsky JM, Pearson NA, Williams DK, Grobe JL, Tolentino T, Lloyd KCK, Adams SH. Coupling of energy intake and energy expenditure across a temperature spectrum: impact of diet-induced obesity in mice. Am J Physiol Endocrinol Metab. 2020 Sep 01;319(3):E472-E484. PMCID: PMC7509245 |
66. Nuckols VR, Holwerda SW, Luehrs RE, DuBose LE, Stroud AK, Brandt D, Betz AM, Fiedorowicz JG, Scroggins SM, Santillan DA, Grobe JL, Sigmund CD, Santillan MK, Pierce GL. Beat-to-Beat Blood Pressure Variability in the First Trimester Is Associated With the Development of Preeclampsia in a Prospective Cohort: Relation With Aortic Stiffness. Hypertension. 2020 Dec;76(6):1800-1807. PMCID: PMC7706825 |
67. Segar JL, Balapattabi K, Reho JJ, Grobe CC, Burnett CML, Grobe JL. Quantification of body fluid compartmentalization by combined time-domain nuclear magnetic resonance and bioimpedance spectroscopy. Am J Physiol Regul Integr Comp Physiol. 2021 Jan 01;320(1):R44-R54. PMCID: PMC7847054 |
68. Ye Y, Abu El Haija M, Morgan DA, Guo D, Song Y, Frank A, Tian L, Riedl RA, Burnett CML, Gao Z, Zhu Z, Shahi SK, Zarei K, Couvelard A, Poté N, Ribeiro-Parenti L, Bado A, Noureddine L, Bellizzi A, Kievit P, Mangalam AK, Zingman LV, Le Gall M, Grobe JL, Kaplan LM, Clegg D, Rahmouni K, Mokadem M. Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass. Cell Rep. 2020 Oct 27;33(4):108270. PMCID: PMC7660289 |
69. Zanaty M, Seara FAC, Nakagawa P, Deng G, Mathieu NM, Balapattabi K, Karnik SS, Grobe JL, Sigmund CD. β-Arrestin-Biased Agonist Targeting the Brain AT<sub>1</sub>R (Angiotensin II Type 1 Receptor) Increases Aversion to Saline and Lowers Blood Pressure in Deoxycorticosterone Acetate-Salt Hypertension. Hypertension. 2021 Feb;77(2):420-431. PMCID: PMC7855825 |
70. Segar JL, Grobe CC, Balapattabi K, Ritter ML, Reho JJ, Grobe JL. Dissociable effects of dietary sodium in early life upon somatic growth, fluid homeostasis, and spatial memory in mice of both sexes. Am J Physiol Regul Integr Comp Physiol. 2021 Apr 01;320(4):R438-R451. PMCID: PMC8238146 |
71. Gumusoglu SB, Chilukuri ASS, Hing BWQ, Scroggins SM, Kundu S, Sandgren JA, Santillan MK, Santillan DA, Grobe JL, Stevens HE. Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model. Transl Psychiatry. 2021 Jan 28;11(1):79. PMCID: PMC7844013 |
72. Wu J, Fang S, Lu KT, Wackman K, Schwartzman ML, Dikalov SI, Grobe JL, Sigmund CD. EP3 (E-Prostanoid 3) Receptor Mediates Impaired Vasodilation in a Mouse Model of Salt-Sensitive Hypertension. Hypertension. 2021 Apr;77(4):1399-1411. PMCID: PMC7946772 |
73. Rouabhi M, Guo DF, Morgan DA, Zhu Z, López M, Zingman L, Grobe JL, Rahmouni K. BBSome ablation in SF1 neurons causes obesity without comorbidities. Mol Metab. 2021 Jun;48:101211. PMCID: PMC8065214 |
74. Wagner VA, Clark KC, Carrillo-Sáenz L, Holl KA, Velez-Bermudez M, Simonsen D, Grobe JL, Wang K, Thurman A, Solberg Woods LC, Lehmler HJ, Kwitek AE. Bisphenol F Exposure in Adolescent Heterogeneous Stock Rats Affects Growth and Adiposity. Toxicol Sci. 2021 May 27;181(2):246-261. PMCID: PMC8163043 |
75. Riedl RA, Burnett CML, Pearson NA, Reho JJ, Mokadem M, Edwards RA, Kindel TL, Kirby JR, Grobe JL. Gut Microbiota Represent a Major Thermogenic Biomass. Function (Oxf). 2021;2(3):zqab019. PMCID: PMC8055641 |
76. Segar JL, Grobe CC, Grobe JL. Maturational changes in sodium metabolism in periviable infants. Pediatr Nephrol. 2021 Nov;36(11):3693-3698. PMCID: PMC8815317 |
77. De Silva TM, Modrick ML, Grobe JL, Faraci FM. Activation of the Central Renin-Angiotensin System Causes Local Cerebrovascular Dysfunction. Stroke. 2021 Jul;52(7):2404-2413. PMCID: PMC8262118 |
78. Nakagawa P, Gomez J, Lu KT, Grobe JL, Sigmund CD. Studies of salt and stress sensitivity on arterial pressure in renin-b deficient mice. PLoS One. 2021;16(7):e0250807. PMCID: PMC8318244 |
79. Xu H, Thomas MJ, Kaul S, Kallinger R, Ouweneel AB, Maruko E, Oussaada SM, Jongejan A, Cense HA, Nieuwdorp M, Serlie MJ, Goldberg IJ, Civelek M, Parks BW, Lusis AJ, Knaack D, Schill RL, May SC, Reho JJ, Grobe JL, Gantner B, Sahoo D, Sorci-Thomas MG. Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake. Arterioscler Thromb Vasc Biol. 2021 Nov;41(11):2708-2725. PMCID: PMC8551036 |
80. Ziegler AA, Grobe CC, Reho JJ, Jensen ES, Thulin JD, Segar JL, Grobe JL. Short-term Housing in Metabolic Caging on Measures of Energy and Fluid Balance in Male C57BL/6J Mice ( <i>Mus musculus</i>). J Am Assoc Lab Anim Sci. 2022 Mar 01;61(2):132-139. PMCID: PMC8956215 |
81. Herz H, Song Y, Ye Y, Tian L, Linden B, Abu El Haija M, Chu Y, Grobe JL, Lengeling RW, Mokadem M. NSAID-Induced Enteropathy Affects Regulation of Hepatic Glucose Production by Decreasing GLP-1 Secretion. Nutrients. 2021 Dec 28;14(1). PMCID: PMC8746549 |
82. Lozada-Fernández VV, deLeon O, Kellogg SL, Saravia FL, Hadiono MA, Atkinson SN, Grobe JL, Kirby JR. Nicotinamide Riboside-Conditioned Microbiota Deflects High-Fat Diet-Induced Weight Gain in Mice. mSystems. 2022 Feb 22;7(1):e0023021. PMCID: PMC8788325 |
83. Reho JJ, Nakagawa P, Mouradian GC Jr, Grobe CC, Saravia FL, Burnett CML, Kwitek AE, Kirby JR, Segar JL, Hodges MR, Sigmund CD, Grobe JL. Methods for the Comprehensive <i>in vivo</i> Analysis of Energy Flux, Fluid Homeostasis, Blood Pressure, and Ventilatory Function in Rodents. Front Physiol. 2022;13:855054. PMCID: PMC8914175 |
84. Patil CN, Ritter ML, Wackman KK, Oliveira V, Balapattabi K, Grobe CC, Brozoski DT, Reho JJ, Nakagawa P, Mouradian GC Jr, Kriegel AJ, Kwitek AE, Hodges MR, Segar JL, Sigmund CD, Grobe JL. Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet. Am J Physiol Regul Integr Comp Physiol. 2022 Jun 01;322(6):R467-R485. PMCID: PMC9054347 |
85. Oliveira V, Riedl RA, Claflin KE, Mathieu NM, Ritter ML, Balapattabi K, Wackman KK, Reho JJ, Brozoski DT, Morgan DA, Cui H, Rahmouni K, Burnett CML, Nakagawa P, Sigmund CD, Morselli LL, Grobe JL. Melanocortin MC<sub>4</sub>R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain. Physiol Genomics. 2022 Jun 01;54(6):196-205. PMCID: PMC9131927 |
86. Wu J, Fang S, Lu KT, Kumar G, Reho JJ, Brozoski DT, Otanwa AJ, Hu C, Nair AR, Wackman KK, Agbor LN, Grobe JL, Sigmund CD. Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension. Function (Oxf). 2022;3(3):zqac017. PMCID: PMC9045850 |
87. Clark KC, Wagner VA, Holl KL, Reho JJ, Tutaj M, Smith JR, Dwinell MR, Grobe JL, Kwitek AE. Body Composition and Metabolic Changes in a Lyon Hypertensive Congenic Rat and Identification of <i>Ercc6l2</i> as a Positional Candidate Gene. Front Genet. 2022;13:903971. PMCID: PMC9263446 |
88. Oliveira V, Reho JJ, Balapattabi K, Ritter ML, Mathieu NM, Opichka MA, Lu KT, Grobe CC, Silva SD Jr, Wackman KK, Nakagawa P, Segar JL, Sigmund CD, Grobe JL. Chronic intracerebroventricular infusion of angiotensin II causes dose- and sex-dependent effects on intake behaviors and energy homeostasis in C57BL/6J mice. Am J Physiol Regul Integr Comp Physiol. 2022 Oct 01;323(4):R410-R421. PMCID: PMC9512112 |
89. Mouradian GC Jr, Liu P, Nakagawa P, Duffy E, Gomez Vargas J, Balapattabi K, Grobe JL, Sigmund CD, Hodges MR. Patch-to-Seq and Transcriptomic Analyses Yield Molecular Markers of Functionally Distinct Brainstem Serotonin Neurons. Front Synaptic Neurosci. 2022;14:910820. PMCID: PMC9280690 |
90. Mathieu NM, Nakagawa P, Grobe CC, Reho JJ, Brozoski DT, Lu KT, Wackman KK, Ritter ML, Segar JL, Grobe JL, Sigmund CD. ARRB2 (β-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation. Hypertension. 2022 Nov;79(11):2480-2492. PMCID: PMC9669141 |
91. Ritter ML, Deng G, Reho JJ, Deng Y, Sapouckey SA, Opichka MA, Balapattabi K, Wackman KK, Brozoski DT, Lu KT, Paradee WJ, Gibson-Corley KN, Cui H, Nakagawa P, Morselli LL, Sigmund CD, Grobe JL. Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (<i>Rgs2</i>) From Cells Expressing Agouti-Related Peptide or the ANG (Angiotensin) II Type 1A Receptor in Mice. Hypertension. 2022 Dec;79(12):2843-2853. PMCID: PMC9649888 |
92. Deng Y, Dickey JE, Saito K, Deng G, Singh U, Jiang J, Toth BA, Zhu Z, Zingman LV, Resch JM, Grobe JL, Cui H. Elucidating the role of Rgs2 expression in the PVN for metabolic homeostasis in mice. Mol Metab. 2022 Dec;66:101622. PMCID: PMC9638802 |
93. Alexander BT, South AM, August P, Bertagnolli M, Ferranti EP, Grobe JL, Jones EJ, Loria AS, Safdar B, Sequeira-Lopez MLS, American Heart Association Council on the Kidney in Cardiovascular Disease; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Hypertension; and Council on Lifestyle and Cardiometabolic Health. Appraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and Offspring Cardiovascular Health Across the Life Course: Moving the Field Forward: A Scientific Statement From the American Heart Association. Hypertension. 2023 May;80(5):e75-e89. PMCID: PMC10242542 |
94. Wagner VA, Holl KL, Clark KC, Reho JJ, Dwinell MR, Lehmler HJ, Raff H, Grobe JL, Kwitek AE. Genetic background in the rat affects endocrine and metabolic outcomes of bisphenol F exposure. Toxicol Sci. 2023 Jun 28;194(1):84-100. PMCID: PMC10306406 |
95. Wagner VA, Deng G, Claflin KE, Ritter ML, Cui H, Nakagawa P, Sigmund CD, Morselli LL, Grobe JL, Kwitek AE. Cell-specific transcriptome changes in the hypothalamic arcuate nucleus in a mouse deoxycorticosterone acetate-salt model of hypertension. Front Cell Neurosci. 2023;17:1207350. PMCID: PMC10244568 |
96. Mathieu NM, Nakagawa P, Grobe JL, Sigmund CD. Insights Into the Role of Angiotensin-II AT<sub>1</sub> Receptor-Dependent β-Arrestin Signaling in Cardiovascular Disease. Hypertension. 2024 Jan;81(1):6-16. PMCID: PMC10787814 |
97. Grobe CC, Reho JJ, Brown-Williams D, Ziegler AA, Mathieu NM, Lawton SBR, Fekete EM, Brozoski DT, Wackman KK, Burnett CML, Nakagawa P, Sigmund CD, Segar JL, Grobe JL. Cardiometabolic Effects of DOCA-Salt in Mice Depend on Ambient Temperature. Hypertension. 2023 Sep;80(9):1871-1880. PMCID: PMC10528934 |
98. Balapattabi K, Yavuz Y, Jiang J, Deng G, Mathieu NM, Ritter ML, Opichka MA, Reho JJ, McCorvy JD, Nakagawa P, Morselli LL, Mouradian GC Jr, Atasoy D, Cui H, Hodges MR, Sigmund CD, Grobe JL. Angiotensin AT<sub>1A</sub> receptor signal switching in Agouti-related peptide neurons mediates metabolic rate adaptation during obesity. Cell Rep. 2023 Aug 29;42(8):112935. PMCID: PMC10530419 |
99. Mathieu NM, Fekete EM, Muskus PC, Brozoski DT, Lu KT, Wackman KK, Gomez J, Fang S, Reho JJ, Grobe CC, Vazirabad I, Mouradian GC Jr, Hodges MR, Segar JL, Grobe JL, Sigmund CD, Nakagawa P. Genetic Ablation of Prorenin Receptor in the Rostral Ventrolateral Medulla Influences Blood Pressure and Hydromineral Balance in Deoxycorticosterone-Salt Hypertension. Function (Oxf). 2023;4(5):zqad043. PMCID: PMC10440998 |
100. Ziegler AA, Lawton SBR, Grobe CC, Reho JJ, Freudinger BP, Burnett CML, Nakagawa P, Grobe JL, Segar JL. Early-life sodium deprivation programs long-term changes in ingestive behaviors and energy expenditure in C57BL/6J mice. Am J Physiol Regul Integr Comp Physiol. 2023 Nov 01;325(5):R576-R592. PMCID: PMC10866575 |
101. Wagner VA, Holl KL, Clark KC, Reho JJ, Lehmler HJ, Wang K, Grobe JL, Dwinell MR, Raff H, Kwitek AE. The Power of the Heterogeneous Stock Rat Founder Strains in Modeling Metabolic Disease. Endocrinology. 2023 Nov 02;164(12). PMCID: PMC10637104 |
102. Opichka MA, Livergood MC, Balapattabi K, Ritter ML, Brozoski DT, Wackman KK, Lu KT, Kozak KN, Wells C, Fogo AB, Gibson-Corley KN, Kwitek AE, Sigmund CD, McIntosh JJ, Grobe JL. Mitochondrial-targeted antioxidant attenuates preeclampsia-like phenotypes induced by syncytiotrophoblast-specific Gαq signaling. Sci Adv. 2023 Dec;9(48):eadg8118. PMCID: PMC10691776 |
103. Ritter ML, Wagner VA, Balapattabi K, Opichka MA, Lu KT, Wackman KK, Reho JJ, Keen HL, Kwitek AE, Morselli LL, Geurts AM, Sigmund CD, Grobe JL. Krüppel-like factor 4 in transcriptional control of the three unique isoforms of Agouti-related peptide in mice. Physiol Genomics. 2024 Mar 01;56(3):265-275. PMCID: PMC10866620 |
104. Lawton SB, Grobe CC, Reho JJ, Raff H, Thulin JD, Jensen ES, Burnett CM, Segar JL, Grobe JL. Differences in Fluid, Electrolyte, and Energy Balance in C57BL/6J Mice (<i>Mus musculus</i>) in Metabolic Caging at Thermoneutral or Standard Room Temperatures. J Am Assoc Lab Anim Sci. 2024 Mar 01;63(2):190-200. PMCID: PMC11022944 |
105. Reho JJ, Muskus PC, Bennett DM, Grobe CC, Burnett CML, Nakagawa P, Segar JL, Sigmund CD, Grobe JL. Modulatory effects of estrous cycle on ingestive behaviors and energy balance in young adult C57BL/6J mice maintained on a phytoestrogen-free diet. Am J Physiol Regul Integr Comp Physiol. 2024 Mar 01;326(3):R242-R253. PMCID: PMC11213288 |
106. Morselli LL, Amjad R, James R, Kindel TL, Kwitek AE, Williams JS, Grobe JL, Kidambi S. Diet in Food Insecurity: A Mediator of Metabolic Health? J Endocr Soc. 2024 Apr 06;8(6):bvae062. PMCID: PMC11017326 |
107. Mathieu NM, Tan EE, Reho JJ, Brozoski DT, Muskus PC, Lu KT, Wackman KK, Grobe JL, Nakagawa P, Sigmund CD. Genetic Deletion of β-Arrestin 2 From the Subfornical Organ and Other Periventricular Nuclei in the Brain Alters Fluid Homeostasis and Blood Pressure. Hypertension. 2024 Jun;81(6):1332-1344. PMCID: PMC11096025 |
108. Wildes MP, Fernando DG, Grobe CC, Reho JJ, Grobe JL, Kidambi S, Kindel TL, Kwitek AE, Segar JL, Williams JS, Morselli LL. Long-term Metabolic Dysfunction Programming in Female Mice by Serial Moderate Restriction of a High-fat High-sucrose Diet. Endocrinology. 2024 Aug 27;165(10). PMCID: PMC11408931 |
109. Ziegler AA, Lawton SBR, Fekete EM, Brozoski DT, Wagner VA, Grobe CC, Sigmund CD, Nakagawa P, Grobe JL, Segar JL. Early-Life Sodium Restriction Programs Autonomic Dysfunction and Salt- Sensitivity in Male C57BL/6J Mice. Am J Physiol Regul Integr Comp Physiol. 2024 Nov 16. |
Books, Chapters, and Reviews |
1. Katovich MJ, Grobe JL, Raizada MK. Gene therapy for hypertension: current targets and consideration of novel targets. In: Cardiovascular Genomics. Humana Press. 2005. p. 213-246. |
2. Katovich MJ, Grobe JL, Huentelman M, Raizada MK. Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension, Exp Physiol. 2005 May;90(3):299-305. PMID:15640278. |
3. Katovich MJ, Grobe JL, Raizada MK. Angiotensin-(1-7) as an antihypertensive, antifibrotic target, Curr Hypertens Rep. 2008 June;10(3):227-232. PMID:18765095. |
4. Grobe JL, Venegas-Pont M, Sigmund CD, Ryan MJ. PPARgamma differentially regulates energy substrate handling in brown vs. white adipose: focus on "The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake"., Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1325-R1326. PMCID: 3597227. |
5. Grobe JL, Rahmouni K. Editoral Focus: A fat contribution to RAS activation and blood pressure control: evidence from angiotensinogen conditional null mice. Focus on: "Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice, Am J Physiol: Regul Integr Comp Physiol. 2012 January 15;302(2):R242-R243. PMID:22071163. |
6. Grobe JL, Rahmouni K. The adipose/circulating renin-angiotensin system cross-talk enters a new dimension, Hypertension. 2012 December;60(6):1389-1390. PMID:23108659. PMCID: 3959780. |
7. Grobe JL, Sigmund CD. Another reason to eat your greens: cardiopulmonary protection by dietary delivery of angiotensin-converting enzyme-2 and angiotensin-(1-7) made in plants, Hypertension. 2014 December;64(6):1182-1183. PMID:25225201. |
8. Coble JL, Grobe JL, Johnson AK, Sigmund CD. Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ, Am J Physiol Regul Integr Comp Physiol. 2015 February 15;308(4):R238-R249. PMID:25519738. PMCID: 4347751. |
9. Sandgren JA, Scroggins SM, Santillan DA, Devor EJ, Gibson-Corley KN, Pierce GL, Sigmund CD, Santillan MK, Grobe JL. Vasopressin: The Missing Link for Preeclampsia?, American journal of physiology. Regulatory, integrative and comparative physiology. 2015 March 25:ajpregu.00073.2015. PMID:25810383. PMCID: 4666952. |
10. Claflin KE, Grobe JL. Control of energy balance by the brain renin-angiotensin system, Current hypertension reports. 2015 May 1;17(5):38. PMID:25833461. |
11. Littlejohn NK, Grobe JL. Opposing tissue-specific roles of angiotensin in the pathogenesis of obesity, and implications for obesity-related hypertension., American journal of physiology. Regulatory, integrative and comparative physiology. 2015 December 15;309(12):R1463-73. PMID:26491099. PMCID: 4698411. |
12. Muntner P, Becker RC, Calhoun D, Chen D, Cowley, Jr AW, Flynn JT, Grobe JL, Kidambi S, Kotchen TA, Lackland DT, Leslie KK, Li Y, Liang M, Lloyd A, Mattson DL, Mendizabal B, Mitsnefes M, Nair A, Pierce GL, Pollock JS, Safford MM, Santillan MK, Sigmund CD, Thomas SJ, Urbina EM. Introduction to the American Heart Association's Hypertension Strategically Focused Research Network., Hypertension (Dallas, Tex. : 1979). 2016 April 1;67(4):674-80. PMID:26902490. PMCID: 5135412. |
13. Sandgren JA, Santillan MK, Grobe JL. Breaking a Mother's Heart: Circulating Antiangiogenic Factors and Hypertension During Pregnancy Correlate With Specific Cardiac Dysfunctions., Hypertension (Dallas, Tex. : 1979). 2016 June 1;67(6):1119-20. PMID:27113050. PMCID: 4865412. |
14. Riedl RA, Atkinson SN, Burnett CML, Grobe JL, Kirby JR. The Gut Microbiome, Energy Homeostasis, and Implications for Hypertension., Current hypertension reports. 2017 April 1;19(4):27. PMID:28316052. PMCID: 5773096. |
15. Grobe JL. Comprehensive Assessments of Energy Balance in Mice. The Renin-Angiotensin-Aldosterone System: Methods and Protocols. Methods Molecular Biology Series. Springer. 2017. p. 123-146. PMID:28500600. PMCID: 5582947. |
16. Sapouckey SA, Deng G, Sigmund CD, Grobe JL. Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism., Physiological genomics. 2017 December 1;49(12):722-732. PMID:28986397. PMCID: PMC5814669. |
17. Morselli LL, Claflin KE, Cui H, Grobe JL. Control of Energy Expenditure by AgRP Neurons of the Arcuate Nucleus: Neurocircuitry, Signaling Pathways, and Angiotensin., Current hypertension reports. 2018 March 19;20(3):25. PMID:29556733. PMCID: PMC5882211. |
18. Perschbacher KJ, Deng G, Fisher RA, Gibson-Corley KN, Santillan MK, Grobe JL. Regulators of G-Protein Signaling in Cardiovascular Function During Pregnancy., Physiological genomics. 2018 April 27;50(8):590-604. PMID:29702036. PMCID: PMC6139632. |
19. Deng G, Grobe JL. The renin-angiotensin system in the arcuate nucleus controls resting metabolic rate, Current Opinion in Nephrology. 2018 December 10. PMID:30531199. PMCID: PMC6366639. |
20. Nakagawa P, Gomez J, Grobe JL, Sigmund CD. The Renin-Angiotensin System in the Central Nervous System and Its Role in Blood Pressure Regulation. Curr Hypertens Rep. 2020 Jan 10;22(1):7. PMCID: PMC7101821 |
21. Sigmund CD, Grobe JL. A colorful view of the brain renin-angiotensin system. Hypertens Res. 2020 Apr;43(4):357-359. PMCID: PMC7107486 |
22. Oliveira V, Kwitek AE, Sigmund CD, Morselli LL, Grobe JL. Recent Advances in Hypertension: Intersection of Metabolic and Blood Pressure Regulatory Circuits in the Central Nervous System. Hypertension. 2021 Apr;77(4):1061-1068. PMCID: PMC7990288 |
23. Santillan MK, Becker RC, Calhoun DA, Cowley AW, Flynn JT, Grobe JL, Kotchen TA, Lackland DT, Leslie KK, Liang M, Mattson DL, Meyers KE, Mitsnefes MM, Muntner PM, Pierce GL, Pollock JS, Sigmund CD, Thomas SJ, Urbina EM, Kidambi S. Team Science: American Heart Association's Hypertension Strategically Focused Research Network Experience. Hypertension. 2021 Jun;77(6):1857-1866. PMCID: PMC8986150 |
24. Deng Y, Deng G, Grobe JL, Cui H. Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control. Front Physiol. 2021;12:691226. PMCID: PMC8274634 |
25. Opichka MA, Rappelt MW, Gutterman DD, Grobe JL, McIntosh JJ. Vascular Dysfunction in Preeclampsia. Cells. 2021 Nov 06;10(11). PMCID: PMC8616535 |
26. Araya BR, Ziegler AA, Grobe CC, Grobe JL, Segar JL. Sodium and Growth in Preterm Infants: A Review. Newborn (Clarksville). 2023;2(2):142-147. PMCID: PMC10445331 |
27. Opichka MA, Livergood MC, Grobe JL, McIntosh JJ. Cardiovascular Neuroendocrinology of Pregnancy Masterclass in Neuroendocrinology. 2023;14:111-135. |
28. Grobe JL, Potthoff MJ. CNS Regulation of Energy Balance Handbook of Obesity - Volume 1: Epidemiology, Etiology, and Physiopathology, Fourth Edition. 1 January 2023;1:207-215. |
29. Lawton SBR, Wagner VA, Nakagawa P, Segar JL, Sigmund CD, Morselli LL, Grobe JL. Angiotensin in the Arcuate: Mechanisms Integrating Cardiometabolic Control: The 2022 COH Mid-Career Award for Research Excellence. Hypertension. 2024 Nov;81(11):2209-2217. PMCID: PMC11483214 |
Patents |
1. Grobe JL, Santillan MK, Santillan DA, inventors; Therapeutic strategies for the treatment of preeclampsia. United States Patent Application #20180228806; PCT/US2014/015631. United States Patent #9,937,182. (April 10, 2018). |
2. Grobe JL, Santillan MK, inventors; Diagnostic tools to predict onset of preeclampsia / Method using copeptin to predict onset of preeclampsia. United States Patent Application #20150377876; PCT/US2014/015627. European Patent #2954324 (July 31, 2019). |
3. Grobe JL, Santillan MK, Santillan DA, inventors; Detection of predictors of preeclampsia. United States Patent Application #20200124612; PCT/US2018/027152, Int'l filing date 11 April 2018 / priority date 11 April 2017. |
4. Grobe JL, Santillan MK, Santillan DA, inventors; Early prediction of preeclampsia. United States Patent Application #20170315130. US15/583,400, priority date 01 May 2017. |
