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CURRICULUM VITAE

Justin L. Grobe PhD
Associate Professor
Department of Physiology
& Department of Biomedical Engineering;
Director, Comprehensive Rodent Metabolic Phenotyping Core;
Vice-Chair, Institutional Animal Care & Use Committee
OFFICE ADDRESS:
Cardiovascular Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226
Phone: 414-955-4981
Email: jgrobe@mcw.edu

EDUCATION:
08/1997 - 05/2001 BS (Biology) + BA (Chemistry); Mentor: Christopher C. Barney, PhD, Hope College, Holland, MI
08/2001 - 05/2006 PhD (Pharmacodynamics); Mentor: Michael J. Katovich, PhD, University of Florida, Gainesville, FL

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
05/2006 - 09/2006 Postdoctoral Fellow (laboratory of Mohan K. Raizada, PhD), Department of Physiology & Functional Genomics, College of Medicine, University of Florida, Gainesville, FL
09/2006 - 06/2010 Postdoctoral Fellow (laboratory of Curt D. Sigmund, PhD), Department of Internal Medicine, Roy J. & Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA

FACULTY APPOINTMENTS:
07/2010 - 05/2012 Associate (Instructor equivalent), Department of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA
06/2012 - 06/2017 Assistant Professor (Tenure Track), Department of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA
07/2017 - 06/2019 Associate Professor with Tenure, Department of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA
07/2019 - Present Associate Professor with Tenure, Departments of Physiology & Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI

RESEARCH ADMINISTRATIVE APPOINTMENTS:
07/2019 - Present Director, Comprehensive Rodent Metabolic Phenotyping Core, Medical College of Wisconsin, Milwaukee, WI
08/2022 - Present Vice-Chair, Institutional Animal Care & Use Committee (IACUC), Medical College of Wisconsin, Milwaukee, WI

AWARDS AND HONORS:
2001 Departmental Service Award - Department of Biology, Hope College
2001 Frank Patterson Memorial Award - Department of Biology, Hope College
2005 Association for Chemoreception Sciences (AChemS) Conference Travel Award - UF Center for Smell and Taste, University of Florida
2006 First Place, Oral Presentation (Senior Division), 19th Annual Research Showcase, University of Florida College of Pharmacy
2007 Merck New Investigator Award, American Heart Association Council on Hypertension
2007 Clinical Science Young Investigator Award, sponsored by Portland Press, American Physiological Society Cardiovascular Section
2008 Poster Award, Gordon Research Conference: Angiotensin
2008 Research Recognition Award, American Physiological Society Neural Control and Autonomic Regulation Section
2008 Young Investigator Award, Society for Experimental Biology and Medicine
2008 New Investigator Travel Award, American Heart Association Council on Hypertension
2008 Caroline tum Suden / Frances A. Hellebrandt Professional Opportunity Award, American Physiological Society
2009 Carver College of Medicine Health Sciences Research Week Poster Presentation Award, Postdoctoral Fellow Division, University of Iowa
2011 New Investigator of the Month, International Society of Hypertension
2012 Elected to "Fellow of the American Heart Association" (FAHA), American Heart Association Council on Hypertension
2014 Young Scholar Award, American Society of Hypertension
2014 - 2015 Recognized as among top 10 reviewers for journal, Hypertension (journal)
2015 Young Investigator Award , American Physiological Society Water & Electrolyte Homeostasis Section
2015 Harry Goldblatt New Investigator Award, American Heart Association Council on Hypertension
2016 Office of the Vice President for Research & Economic Development Inventor Award, University of Iowa
2016 "Forty Under 40" Award, Cedar Rapids / Iowa City area Corridor Business Journal
2017 Awarded Tenure, University of Iowa
2017 Arthur C. Guyton Award for Excellence in Integrative Physiology, American Physiology Society
2017 Office of the Vice President for Research & Economic Development Inventor Award, University of Iowa
2018 - 2022 Established Investigator Award, American Heart Association
2018 Office of the Vice President for Research & Economic Development Inventor Award, University of Iowa
2018 Outstanding Reviewer Award, Experimental Biology and Medicine (journal)
2019 Awarded Tenure, Medical College of Wisconsin
2021 Elected to Fellow of the American Physiological Society (FAPS), American Physiological Society
2021 MCW Outstanding Medical Student Teacher for 2020-2021 (Physiology), Medical College of Wisconsin
2022 Mid-Career Award for Research Excellence, American Heart Association Council on Hypertension

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
1998 - 2001 Beta Beta Beta Undergraduate Biological Honor Society (Hope College)
1999 - Present American Heart Association (member 120721042; elected to Fellow (FAHA) in 2012)
1999 - Present American Physiological Society (member 00033392; elected to Fellow (FAPS) in 2021)
2000 - 2013 Sigma Xi
2005 - 2013 Society for Experimental Biology and Medicine
2011 - 2013 International Society of Hypertension
2013 - Present American Diabetes Association (member 08344175 / 0520608555)
2014 - 2018 American Society for Pharmacology and Experimental Therapeutics (member 49382)
2018 - Present The Obesity Society (member 25073)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorial Board
01/2012 - 12/2024 Hypertension
2015 - 2021 Physiological Genomics (Section Editor)
2018 - Present JAHA: Journal of the American Heart Association (frequent Guest Associate Editor)
2019 - 2021 Biology of Sex Differences
Ad-Hoc Reviewer
2007 - Present Hypertension
2008 - Present American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology
2008 - Present Physiological Genomics
2009 - Present Obesity
2009 - Present Circulation Research
2009 - Present Biochemical Pharmacology
2011 - Present American Journal of Physiology: Heart and Circulatory Physiology
2011 - Present British Journal of Pharmacology
2011 - Present Regulatory Peptides
2011 - Present International Journal of Hypertension
2011 - Present Cellular Physiology and Biochemistry
2012 - Present PLOS ONE
2012 - Present Journal of Cardiovascular Pharmacology and Therapeutics
2012 - Present Clinical and Experimental Pharmacology and Physiology
2012 - Present Journal of Applied Physiology
2013 - Present Experimental Physiology
2013 - Present Hypertension Research
2013 - Present Cellular and Molecular Neurobiology
2013 - Present Acta Physiologica
2014 - Present Journal of Cardiovascular Pharmacology
2014 - Present Endocrine
2014 - Present Yonsei Medical Journal
2014 - Present Journal of the American Heart Association (JAHA)
2014 - Present Advances in Pharmacology
2014 - Present BMC Medical Genetics
2014 - Present Microcirculation
2014 - Present Diabetes
2015 - Present Neuropsychopharmacology
2015 - Present Journal of Thermal Biology
2016 - Present Scientific Reports
2016 - Present American Journal of Physiology: Endocrinology & Metabolism
2018 - Present Nutrition and Diabetes

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
2000 - 2001 President, Alpha Eta Chapter, Beta Beta Beta Biological Honor Society, Hope College
2008 - 2010 Member, Trainee Advocacy Committee, American Heart Association / Council on Hypertension
2010 - 2013 Chair, Trainee Advocacy Committee, American Heart Association / Council on Hypertension
2011 - 2012 Member, Early Career Task Force, American Heart Association / Council Operations Committee
2013 - 2023 Member, Nominating Committee, American Heart Association / Council on Hypertension
2013 Member, Hypertension Summer School Planning Committee, American Heart Association / Council on Hypertension
2014 - 2017 Vice-Chair, Research Committee, American Heart Association / Midwest Affiliate
2015 - 2016 Coordinator, Data Diuresis Session, American Physiological Society / Water & Electrolyte Homeostasis Section
11/2018 Ad hoc reviewer, F10A-R (Fellowships) study section, NIH CSR
2018 - 2023 Member, Membership & Communications Committee, American Heart Association / Council on Hypertension
02/2019 Ad hoc reviewer, Hypertension & Microcirculation (HM) study section, NIH CSR
04/2019 Ad hoc reviewer, Vascular & Hematology AREA (R15) study section, NIH CSR
2019 - 2023 Member, HTN Fall Specialty Conference Planning Committee, American Heart Association / Council on Hypertension
02/2020 Ad hoc reviewer, P01 Special Emphasis Panel, NIH CSR
06/2020 Ad hoc reviewer, Hypertension & Microcirculation (HM) study section, NIH CSR
2020 - 06/30/2022 Member, Council Operations Committee / Mid-Career Subcommittee, American Heart Association
2020 - 2022 Member, Water & Electrolyte Homeostasis Section Awards Committee, American Physiological Society
02/2021 Ad hoc reviewer, P01 Special Emphasis Panel, NIH CSR
06/2021 Ad hoc reviewer, Translational Research Institute for Space Health (TRISH) Biomedical Research Advances for Space Health (BRASH2101), National Aeronautics and Space Administration (NASA)
10/2021 Ad hoc reviewer, P01 Special Emphasis Panel, NIH CSR
01/2022 Ad hoc reviewer, P01 Special Emphasis Panel, NIH CSR
06/2022 Ad hoc reviewer, POMD study section, NIH CSR
11/2022 Ad hoc reviewer, Fellowship Clinical 1 (pre- and post-doctoral fellowship), American Heart Association

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
R01 HL134850 Interaction between leptin and angiotensin in the pathogenesis of obesity-hypertension
Source:
NIH / NHLBI
Role:
Principal Investigator
PI:
Grobe
Dates:
01/2017 - 12/2021
Direct Funds:
$1,250,000 (total for all years; A1 resubmission of renewal application will be reviewed in Oct 2022)
  
Title:
18EIA33890055 Hypothalamic mechanisms of cardiometabolic and obstetric disease
Source:
American Heart Association
Role:
Principal Investigator
PI:
Grobe
Dates:
01/2018 - 12/2022
Direct Funds:
$400,000 (total for all years)
  
Title:
P01 HL084207 Genetic and Signaling Mechanisms in the Central Regulation of Blood Pressure
Source:
NIH / NHLBI
Role:
Principal Investigator, Project 4
PI:
PI: Grobe / PD: CD Sigmund
Dates:
08/2018 - 07/2023
Direct Funds:
$1,446,915 (total for all years)
  
Title:
MCW CTSI Obesity Ensemble
Source:
MCW Clinical & Translational Science Institute / National Institutes of Health (UL1TR001436)
Role:
Ensemble Member
PI:
Shaker
Dates:
2020 - Present
Direct Funds:
$50,000 (initial)
  
Title:
MCW CTSI "Preconception To Toddler Study (PTTS)" Ensemble
Source:
MCW Clinical & Translational Science Institute / National Institutes of Health (UL1TR001436)
Role:
Ensemble Member
PI:
Shaker
Dates:
2021 - Present
Direct Funds:
$35,000 (initial)
  
Title:
R01 DK133121 Impact of Early Life Sodium Intake on Growth and Metabolism - Role of Hypothalamic Mechanisms
Source:
NIH / NIDDK
Role:
Multiple-PI
PI:
Grobe + Segar (MPI)
Dates:
08/12/2022 - 05/31/2026
Direct Funds:
$1,948,108 (total for 4 years)
  
Prior
Peer Review
Title:
NSF REU Fellowship, Hope College
Source:
National Science Foundation
Role:
Principal Investigator
PI:
Grobe
Dates:
05/1998 - 08/1998
Direct Funds:
$2,500
  
Title:
Undergraduate Summer Research Fellowship
Source:
American Heart Association Midwest Affiliate
Role:
Principal Investigator
PI:
Grobe
Dates:
05/1999 - 08/1999
Direct Funds:
$2,500
  
Title:
NSF REU Fellowship, University of Florida
Source:
National Science Foundation
Role:
Principal Investigator
PI:
Grobe
Dates:
05/2000 - 08/2000
Direct Funds:
$2,500
  
Title:
Alumni Fellowship
Source:
University of Florida College of Pharmacy
Role:
Principal Investigator
PI:
Grobe
Dates:
08/2001 - 06/2003
Direct Funds:
$40,000 (total for all years)
  
Title:
Pre-doctoral Research Fellowship 0315130B "Attenuation of Experimental Hypertension by Lentiviral Delivery of Tetracycline-Regulated Angiotensinogen Antisense"
Source:
American Heart Association, Florida/Puerto Rico Affiliate
Role:
Principal Investigator
PI:
Grobe
Dates:
07/2003 - 06/2005
Direct Funds:
$38,000 (total for all years)
  
Title:
Implications for Blood Pressure Control in Pregnancy"
Source:
American Heart Association, Florida/Puerto Rico Affiliate
Role:
Principal Investigator
PI:
Grobe
Dates:
07/2005 - 06/2006
Direct Funds:
$19,000
  
Title:
T32 HL007121 Cardiovascular Interdisciplinary Research Fellowship
Source:
NIH / NHLBI
Role:
Principal Investigator
PI:
Grobe
Dates:
08/2006 - 08/2007
Direct Funds:
$35,000
  
Title:
Post-doctoral Fellowship in Physiological Genomics
Source:
American Physiology Society
Role:
Principal Investigator
PI:
Grobe
Dates:
08/2007 - 08/2009
Direct Funds:
$79,000 (total for all years)
  
Title:
T32 DK007690 Training in Kidney Disease, Hypertension, Cell Biology
Source:
NIH / NIDDK
Role:
Principal Investigator
PI:
Grobe
Dates:
07/2009 - 06/2010
Direct Funds:
$42,000
  
Title:
K99 HL098276 Metabolism, Fluid Balance, and Hypertension
Source:
NIH / NHLBI
Role:
Principal Investigator
PI:
Grobe
Dates:
06/2010 - 05/2012
Direct Funds:
$197,815 (total for all years)
  
Title:
R00 HL098276 Metabolism, Fluid Balance, and Hypertension
Source:
NIH / NHLBI
Role:
Principal Investigator
PI:
Grobe
Dates:
06/2012 - 05/2015
Direct Funds:
$546,443 (total for all years)
  
Title:
All in the head? Investigating the Molecular Role of Vasopressin in Preeeclampsia
Source:
University of Iowa Carver Collaborative Pilot Grant
Role:
Co-Principal Investigator (with MK Santillan)
PI:
Grobe + Santillan
Dates:
03/2013 - 02/2014
Direct Funds:
$50,000
  
Title:
P01 HL084207 Genetic and Signaling Mechanisms in the Central Regulation of Blood Pressure
Source:
NIH / NHLBI
Role:
Co-I
PI:
Sigmund
Dates:
04/2013 - 03/2018
Direct Funds:
$220,000 (total for all years)
  
Title:
1-14-BS-079 Required Interaction of Leptin with Angiotensin in Metabolic Control
Source:
American Diabetes Association
Role:
Principal Investigator
PI:
Grobe
Dates:
01/2014 - 12/2016
Direct Funds:
$270,000 (total for all years)
  
Title:
a common mechanism for the development of obesity and inflammatory pain
Source:
University of Iowa Major Project Pilot Grant
Role:
Co-Principal Investigator (with DP Mohapatra)
PI:
Grobe + Mohapatra
Dates:
01/2014 - 01/2015
Direct Funds:
$50,000
  
Title:
14IRG18710013 Vasopressin as an early-pregnancy initiator of preeclampsia
Source:
American Heart Association
Role:
Principal Investigator
PI:
Grobe
Dates:
01/2014 - 12/2015
Direct Funds:
$150,000 (total for all years)
  
Title:
An Untapped Obesity Target?
Source:
Fraternal Order of Eagles' Diabetes Research Center Pilot Grant
Role:
Principal Investigator
PI:
Grobe
Dates:
09/2014 - 08/2016
Direct Funds:
$100,000 (total for all years)
  
Title:
15SFRN23730000 Molecular Mechanisms of Vasopressin-Induced Preeclampsia
Source:
American Heart Association
Role:
Principal Investigator, Basic Science Project
PI:
PI: Grobe / PD: Sigmund
Dates:
04/2015 - 03/2019
Direct Funds:
$960,000 (total for all years)
  
Title:
Placental GI?q Signaling in Preeclampsia
Source:
UIHC Center for Hypertension Research
Role:
Co-Principal Investigator (with KN Gibson-Corley)
PI:
Grobe + Gibson-Corley
Dates:
07/2016 - 06/2017
Direct Funds:
$40,000
  
Title:
Pilot Project 1
Source:
Carmentix / Esco Ventures
Role:
Co-Principal Investigator
PI:
Grobe + Santillan
Dates:
07/2017 - 12/2017
Direct Funds:
$9,000
  
Title:
Pilot Project 2
Source:
Carmentix / Esco Ventures
Role:
Co-Principal Investigator
PI:
Grobe + Santillan
Dates:
01/2018 - 06/2018
Direct Funds:
$1,500
  
Title:
Are Principal Cells the 'Principal Problem' for Preeclampsia?
Source:
Carver Trust Medical Research Initiative Grant
Role:
Principal Investigator
PI:
Grobe
Dates:
07/2018 - 06/2019
Direct Funds:
$30,000
  
Title:
Relationship between resting metabolic rate, body weight, and gut microbiome in African Americans
Source:
Advancing a Healthier Wisconsin Research & Education Program
Role:
Co-I
PI:
Kidambi
Dates:
2020
Direct Funds:
$250,000
  

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
Internal Medicine Research Day, University of Iowa, 2008
Division of Nephrology Seminar, University of Iowa, 2011
Department of Pharmacology Seminar, University of Iowa, 2011
Molecular & Cellular Biology Interdisciplinary Program Seminar, University of Iowa, 2012
Department of Biochemistry Seminar, University of Iowa, 2012
Obesity Initiative, University of Iowa, 2013
Department of Pharmacology Seminar, University of Iowa, 2013
University of Iowa MSTP (MD/PhD program) summer seminar series, University of Iowa, 2013
40th Anniversary of the Fran??ois M. Abboud Cardiovascular Research Center, University of Iowa, 2014
Biosciences Program Summer Undergraduate Seminar Series, University of Iowa, 2014
Department of Pharmacology Seminar, University of Iowa, 2014
Obesity Research & Education Initiative, University of Iowa, 2015
Department of Pharmacology Seminar, University of Iowa, 2015
IT Community Meeting, University of Iowa, 2015
Biosciences Program Summer Undergraduate Seminar Series, University of Iowa, 2016
Carl Gisolfi Memorial Lecture, University of Iowa, 2017
Toxicology/EHSRC/Superfund Seminar, University of Iowa, 2017
Obesity Research & Education Initiative, University of Iowa, 2018
Single-nuclear RNAseq in the arcuate nucleus of the hypothalamus deconvolutes the cellular and molecular basis of selective leptin resistance and obesity-associated hypertension, Department of Physiology, Medical College of Wisconsin, 2019
Vasopressin, copeptin, and GPCR signaling in preeclampsia, Preeclampsia Working Group, Medical College of Wisconsin, 2019
Vasopressin/Copeptin and Preeclampsia, Cardiovascular Center Annual Retreat, Medical College of Wisconsin, 2019
Regulator of G-protein Signaling-2 in Preeclampsia, WHRP Seminar Series, Medical College of Wisconsin, 2020
Cardiometabolic adaptation during obesity: Role of the local renin-angiotensin system within the arcuate nucleus of the hypothalamus, City-Wide Obesity and Metabolic Disease Grand Rounds, Milwaukee, WI, 2020
Cardiometabolic adaptation during obesity: Role of the local renin-angiotensin system within the arcuate nucleus of the hypothalamus, Department of Physiology "Friends of MCW Physiology" Seminar Series, Milwaukee, WI, 2021
 
Regional
Fraternal Order of Eagles' Missouri, Iowa, Nebraska, Kansas and North & South Dakotas (MINK) section annual conference, Omaha, NE, 2016
American Diabetes Association Iowa / Nebraska / South Dakota section Donor Dinner, Riverside, IA, 2016
Cardiometabolic adaptation during obesity: Role of the local renin-angiotensin system within the arcuate nucleus of the hypothalamus, Departments of Biomedical Sciences & Biological Sciences, Marquette University, 2021
 
National
Gordon Research Conference: Angiotensin, Ventura, CA, 2008
Experimental Biology, San Diego, CA, 2008
American Heart Association Council for High Blood Pressure Research, Tucson, AZ, 2008
Univ. of Florida, Dept of Physiology & Functional Genomics, Gainesville, FL, 2010
University of Kentucky, Graduate Center for Nutritional Sciences, Lexington, KY, 2011
Pennsylvania State University, Dept of Cellular & Molecular Phys, Hershey, PA, 2011
American Heart Association Council for High Blood Pressure Research, Orlando, FL, 2011
Hope College Department of Biology, Holland, MI, 2011
American Heart Association Council for High Blood Pressure Research, Washington, DC, 2012
Gordon Research Seminar: Angiotensin, Orlando, FL, 2012
American Physiological Society NCAR section conference: Autonomic Regulation of Cardiovascular Function in Health and Disease, Omaha, NE, 2012
American Heart Association Council for High Blood Pressure Research, Hypertension Summer School 2013, Columbia, SC, 2013
Experimental Biology, Boston, MA, 2013
Goldblatt Award Competition, American Heart Association Council for High Blood Pressure Research, New Orleans, LA, 2013
Young Scholar Award Lecture, American Society of Hypertension Annual Meeting, New York, NY, 2014
Univ of North Texas Health Sci Ctr, Dept Integrative Physiol & Anatomy, Fort Worth, TX, 2014
University of Wyoming, Laramie, WY, 2015
Goldblatt Award Lecture, American Heart Association Council for High Blood Pressure Research, Washington, DC, 2015
International Academy of Cardiovascular Sciences, Omaha, NE, 2015
Water & Electrolyte Homeostasis Section New Investigator Award, American Physiological Society, Boston, MA, 2015
FASEB Summer Research Conference: Neural Mechanisms in Cardiovascular Regulation: Novel Research and Disease Treatment Strategies, Saxtons River, VT, 2016
Medical College of Wisconsin, Department of Physiology, Milwaukee, WI, 2016
Medical College of Wisconsin, Department of Physiology, Milwaukee, WI, 2018
American Heart Association Council on Hypertension, New Orleans, LA, 2019
Cardiometabolic adaptation during obesity: Role of the local renin-angiotensin system within the arcuate nucleus of the hypothalamus, Center for Integrative Cardiovascular and Metabolic Disease, University of Florida, 2021
Angiotensin within the hypothalamic arcuate nucleus in cardiometabolic control during obesity, Neural & Behavioral Sciences, Penn State College of Medicine, 2021
Resting Metabolism: Control by the Brain, and Contributions of the Gut, Department of Physiology and Pharmacology Molecular Medicine (MOME) Seminar Series, University of Toledo, 2022
Angiotensin in the Arcuate: Unlocking Neural Mechanisms Integrating Cardiometabolic Control in Health & Disease, American Heart Association Council on Hypertension 2022 Scientific Sessions, San Diego, CA, 2022
 
International
Gordon Research Conference: Angiotensin, Lucca (Barga), Italy, 2014
High Blood Pressure Research Council of Australia / Australian Atherosclerosis Society / the Australian Vascular Biology, Hobart (Tazmania), Australia, 2016
Angiotensin action within the arcuate nucleus of the hypothalamus in cardiometabolic control, Vasoactive Peptides, Brazil, 10/16/2021
 

COMMITTEE SERVICE:
Medical College of Wisconsin
2019 - Present Member, Institutional Animal Care & Use Committee (Vice-Chair, 2022-present), Medical College of Wisconsin
2019 - Present Member, MSTP Admissions Committee, Medical College of Wisconsin
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Medical Student Education
2020 - Present Lecturer, Medical Physiology (The Microcirculation and the Lymphatic System: Capillary Fluid Exchange, Interstitial Fluid, and Lymph Flow)
2021 - Present Lecturer, Medical Physiology (Overview of Circulation and Hemodynamics, part 1)
2021 - Present Lecturer, Medical Physiology (Overview of Circulation and Hemodynamics, part 2)
 
Graduate Student Education
2020 - Present Course Director and Primary Instructor - "PHYS 08220: Biostatistics for Health Sciences"
 

EXTRAMURAL TEACHING:
Continuing Medical Education
2012 University of Iowa, Obesity 2012: Building a Dream Team
2014 University of Iowa, Maternal-Fetal Medicine Fellows Conference Lecture "Altered pharmacology in pregnancy"
2015 University of Iowa, Maternal-Fetal Medicine Fellows Conference Lecture "Fluid and electrolyte balance in pregnancy"
 
Graduate Student Education
2011 - 2017 University of Iowa, Lecturer, PCOL:5137 (071:137) - "Neurotransmitters"
2011 - 2013 University of Iowa, Facilitator, PCOL:7270 (650:270) - "Principles of Scholarly Integrity"
2012 University of Iowa, Discussion Leader, "Teaching Your Research"
2012 University of Iowa, Primary Instructor, BISC:5265 (156:265) - "Biosciences Critical Thinking & Communication"
2015 - 2018 University of Iowa, Lecturer, TBM:5001 - "Introduction to Translational Biomedicine"
2015 - 2018 University of Iowa, Course Founder & Director, and Primary Instructor, PCOL:5204 - "Basic Biostatistics & Experimental Design"
2015 University of Iowa, Lecturer, PCOL:8240 - "Basic Pharmacology for Dental Students"
2015 University of Iowa, Course Director, PCOL:6030 - "Topics in Pharmacology"
2016 - 2018 University of Iowa, Lecturer, PATH:5260 (069:260) - "Translational Histopathology"
2019 University of Iowa, Lecturer, MMED:6260 - "Methods for Molecular and Translational Medicine"
 

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
High School Students
Olivia Eckes, Medical College of Wisconsin, 2020, SUPREMES program
 
Medical Students
Micah P. Wildes, Medical College of Wisconsin, 11/2021 - Present Pathway Advisor
 
Graduate Students
PhD Students Advised
McKenzie L. Ritter, Medical College of Wisconsin, 2019 - Present (Physiology), 2021 MCW Physiology T32 Fellowship (HL007852); 2021-2023 AHA predoctoral fellowship (903246)
Megan (Vande Hei) Opichka, Medical College of Wisconsin, 2019 - Present (Physiology), 2021 MCW Physiology T32 Fellowship (HL007852); 2021-2023 American Heart Association Predoctoral Fellowship (826132); 2021 MCW CVC Retreat 2nd place presentation award
Alisha A. Ziegler, Medical College of Wisconsin, 2021 - Present (Physiology), Thesis co-mentor with Jeffrey L. Segar, MD
PhD Committees
Santiago Alvarez (O'Meara lab, Physiology), Medical College of Wisconsin, 2021 - Present
 
Postdoctoral Students
Vanessa A. De Oliveira, PhD, Medical College of Wisconsin, 02/01/2019 - 05/03/2021, (Now faculty at UNIFENAS Universidade, Divinopolis, Brazil)
Chetan N. Patil, PhD, Medical College of Wisconsin, 03/01/2019 - 06/30/2021, (Now a Research Scientist at MCW / Pediatric Nephrology)
Kirthikaa Balapattabi, PhD, Medical College of Wisconsin, 08/01/2019 - Present, 2019 APS NCARnation finalist; 2021 NIH Outstanding Scholars in Neuroscience Award (OSNAP); 2021-2022 American Physiological Society Postdoctoral Fellowship; 2021 NCW Office of Postdoctoral Education Postdoc Professional Developmental Award; 2021-2023 AHA Postdoctoral Fellowship (898067)
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
High School Students
Whitney Li, University of Iowa, 2014, 2014 Secondary Student Training Program (SSTP) fellowship
Jonathan Ni, University of Iowa, 2014 - 2015
Emily G. Suen, University of Iowa, 2015, 2015 Secondary Student Training Program (SSTP) fellowship
Sriram Sugumaran, University of Iowa, 2015
Mengda (Amanda) Liu, University of Iowa, 2016, 2016 Secondary Student Training Program (SSTP) fellowship
Lily Jiaqi Cao, University of Iowa, 2017, 2017 Secondary Student Training Program (SSTP) fellowship
Andrew Usachev, University of Iowa, 2017
 
Undergraduate Students
Beth A. Buehrer, University of Iowa, 2010 - 2012, 2010-2011 Iowa Center for Research by Undergraduates (ICRU) academic year fellowship; 2011 Research at the Capitol Day 2011 (UI representative); 2011 AHA summer research fellowship; 2011-2012 Iowa Center for Research by Undergraduates (ICRU) academic year fellowship
Benjamin J. Weidemann, University of Iowa, 2011 - 2014, 2012 AHA summer fellowship; 2012-2013 Iowa Center for Research by Undergraduates (ICRU) academic year fellowship; 2013 Iowa Center for Research by Undergraduates (ICRU) travel award; 2013 American Physiological Society Undergraduate Research Excellence Fellowship award (UGREF); 2013 University of Iowa "SUMR" pre-MD/PhD program summer research fellowship; 2013 University of Iowa Department of Chemistry Undergraduate Award; 2013-2014 Iowa Center for Research by Undergraduates (ICRU) academic year fellowship; 2014 Research at the Capitol Day UI representative; 2014 American Physiological Society Undergraduate David S. Bruce award; 2014 University of Iowa Department of Pharmacology Amanda Hope Skolnick Memorial Award; 2014 University of Iowa Department of Chemistry Merck Index Award
Susan Voong, University of Iowa, 2012 - 2014, American Physiological Society Undergraduate Summer Research Fellowship award (UGSRF)
Aaron F. Sigmund, University of Iowa, 2012
Kevin V. Tobin, University of Iowa, 2014 - 2016
Danny W. Linggonegoro, University of Iowa, 2014 - 2017, 2015 AHA summer fellowship; 2015-2016 Iowa Center for Research by Undergraduate academic year fellowship; 2016 American Diabetes Association Minority Undergraduate Internship #1-16-MUI-06; 2016 Research at the Capitol Day representative; 2016 University of Iowa Center for Research by Undergraduate Excellence in Undergraduate Research Award; 2016 American Physiological Society Undergraduate Research Excellence Fellowship award (UGREF)
Fabiola I. Morales, University of Iowa, 2014, 2014 University of Iowa Summer Research Opportunities Program (SROP) fellowship
Erica R. Cole, University of Iowa, 2014 - 2016, 2015 Iowa Center for Research by Undergraduates (ICRU) travel award; 2015-2016 Iowa Center for Research by Undergraduates (ICRU) academic year fellowship
Marquis R. Smith, University of Iowa, 2016, 2016 Summer Research Opportunities Program (SROP) fellowship
Shao Yang Zhang, University of Iowa, 2016 - 2019, 2017 American Physiological Society Undergraduate Summer Research Fellowship (UGSRF); 2017-2018 University of Iowa Academic Year Iowa Center for Research by Undergraduates (ICRU) Research Fellowship; 2018 Experimental Biology Barbara A. Horowitz & John M. Horowitz Undergraduate Research Award; 2018 American Physiological Society Undergraduate Research Excellence Fellowship (UGREF); 2018-2019 University of Iowa Academic Year Iowa Center for Research by Undergraduates (ICRU) Research Fellowship; 2019 APS Barbara A. and John M. Horwitz Undergraduate Abstract Award at EB 2019
Alyssa T. Ray, University of Iowa, 2016, 2016 University of Iowa Center for Research by Undergraduate (ICRU) summer fellowship
Jairui Xue, University of Iowa, 2016 - 2018
Phillip Witcher, University of Iowa, 2016, 2016 University of Iowa "SUMR" pre-MD/PhD program summer fellowship
Casee Meincke, University of Iowa, 2017, 2017 University of Iowa Center for Research by Undergraduates (ICRU) summer fellowship
Kevin Chen, University of Iowa, 2018, 2018 American Physiological Society Summer Undergraduate Research Fellowship (UGSRF)
Caitlyn E. Owens, University of Iowa, 2018 - 2019
 
Medical Students
Scott G. Westphal, University of Iowa, 2010
Rick B. Siel, Jr., University of Iowa, 2011, 2011 Medical Student Research Program summer fellowship; 2011 "Edward Heath Award" for outstanding Medical Student research
Matthew D. Folchert, University of Iowa, 2012 - 2016, Research Distinction Track (RDT); 2012 Medical Student Research Program summer fellowship
James Y. Min, University of Iowa, 2013 - 2016, Research Distinction Track (RDT); 2013 Medical Student Research Program 2013 summer fellowship
Ruth A. Riedl, University of Iowa, 2015 - 2019, Medical Student Research Distinction Track (RDT); 2015 University of Iowa "SUMR" pre-MD/PhD program summer fellowship; 2016 Medical Student Research Program summer fellowship; 2016 Outstanding Presentation in Pharmacological Research Award; 2017 Medical Student Research Program summer fellowship; 2017 Outstanding Presentation in Pharmacological Research Award; Research Distinction Track
Kendra L. Frey, University of Iowa, 2017 - 2019, 2017 Medical Student Research Program summer fellowship; Research Distinction Track
John (Jackson) W. Walsh, University of Iowa, 2018 - 2019, 2018 Medical Student Research Program summer fellowship; Research Distinction Track
 
Graduate Students
PhD Committees
Aaron Mickle, University of Iowa, 2012
Kyle Flippo, University of Iowa, 2012
Jacqueline Reilly, University of Iowa, 2013
Balyssa Bell, University of Iowa, 2014
Rachel Minerath, University of Iowa, 2015
Magdalene Ameka, University of Iowa, 2015
Yujia (Jennie) Liu, University of Iowa, 2016
Lucas Bon Durant, University of Iowa, 2016
Samantha N. Atkinson, University of Iowa, 2016
Maria F. Noterman, University of Iowa, 2016
Alexander (Sasha) Tereshchenko, University of Iowa, 2016
Dylan Todd, University of Iowa, 2016
Rebecca K. Autenried, University of Iowa, 2016
Gail I. Harmata, University of Iowa, 2017
Serena (Banu) G??m????oA?lu, University of Iowa, 2017
Frida A. Teran, University of Iowa, 2017
Rachel Schroeder, University of Iowa, 2018
Thomas Pak, University of Iowa, 2018
Grant Walters, University of Iowa, 2018
Mackenzie M. Spicer, University of Iowa, 2019
Aaron A. Jones (Arble lab, Biological Sciences), Marquette University, 2021 - Present
PhD Students Advised
Nicole K. Littlejohn, University of Iowa, Pharmacology, 2012 - 2015 Tissue-specific Roles for the Renin-Angiotensin System in Cardiovascular and Metabolic Regulation, 2013 AHA Council on Hypertension New Investigator Travel Award; 2014-2015 AHA Predoctoral Fellowship #14PRE18330015; 2016 Gordon Research Conference on Angiotensin invited speaker
Jeremy A. Sandgren, University of Iowa, Pharmacology / Medical Scientist Training Program, 2013 - 2019 Vasopressin in Preeclampsia, Medical Scientist Training Program (MSTP) MD/PhD; 2014-2015 Pharmacological Sciences Predoctoral Fellowship T32 GM067795; 2015 Experimental Biology WEH Data Diuresis invited speaker; 2016-2018 AHA Predoctoral Fellowship #16PRE30980043; 2016-2017 University of Iowa Department of Pharmacology Ranbir K. Bhatnagar Scholar Award; 2017 Experimental Biology Water & Electrolyte Homeostasis Section Graduate Student Oral Competition (1st Place)
Kristin E. Claflin (Yin), University of Iowa, Pharmacology, 2013 - 2016 The Brain Renin-Angiotensin System in Metabolic and Cardiovascular Regulation, 2014-2016 AHA Predoctoral Fellowship #14PRE20380401; 2016 Gordon Research Conference on Angiotensin invited speaker
Katherine J. Perschbacher, University of Iowa, Molecular & Cellular Biology, 2015 - 2018 Reduced Placental Expression of Regulator of G Protein Signaling-2 (RGS2) in Preeclampsia: Association, Consequence, and Cause, Molecular & Cellular Biology (2015-2018). 2017 University of Iowa Graduate College Post-comprehensive Research Fellowship; 2017 Molecular & Cellular Biology Graduate Program travel award; 2017-2019 AHA Predoctoral Fellowship #17PRE33660633; 2017-2018 University of Iowa Department of Pharmacology Ranbir K. Bhatnagar Scholar Award; 2017 Finalist / Honorable Mention, University of Iowa Graduate College "3 minute Thesis" Oral Presentation Competition; 2018 Experimental Biology Water & Electrolyte Homeostasis Section Data Diuresis invited speaker
Sarah A. Sapouckey, University of Iowa, Molecular & Cellular Biology, 2016 - 2019 The Renin-Angiotensin System in Metabolism and Development, 2017 Molecular & Cellular Biology Graduate Program travel award; 2018 Gordon Research Conference on Angiotensin invited speaker; 2018-2020 AHA Predoctoral Fellowship #18PRE33960377
MS Committees
Ko-Ting Lu, University of Iowa, 2014
Hannah Van Beek, University of Iowa, 2015
 
Postdoctoral Students
Guorui Deng, PhD, University of Iowa, 01/01/2017 - 06/30/2019, 2017-2019 AHA Strategically Focused Research Network H3 Fellow; 2018 Gordon Research Conference on Angiotensin outstanding poster presentation award; 2018 FOEDRC Research Day outstanding poster presentation award; April 2019 - Mar 2021 American Heart Association Postdoctoral Fellowship (19POST34380239); 2019 Trainee Research Excellence Award sponsored by Data Sciences International (DSI) from the American Physiological Society Physiological a??Omics research group (Now postdoc at University of Iowa)
 
Clinical/Research Fellows
Colin M.L. Burnett, MD, MS, University of Iowa, 05/01/2012 - Present, Currently a Fellow in Cardiology PSTP Residency Program / formerly in Medical School Research Distinction Tract. Awards include: 2012 Medical Student Research Program summer fellowship; 2012 Outstanding Presentation in Pharmacological Research Award; 2013 Medical Student Research Program summer fellowship; 2013 Outstanding Presentation in Pharmacological Research Award (Now in cardiology fellowship at UIHC)
Lisa L. Morselli, MD, PhD, University of Iowa, 07/01/2017 - 06/30/2019, Endocrinology Fellow. 2017-2019 University of Iowa Multidisciplinary Lung Research Career Development Program Fellowship # T32 HL007638 (Now faculty at MCW / Endocrinology)
 

COMMUNITY SERVICE ACTIVITIES:
1997 - 1998 Microbiology teaching laboratory preparation, Hope College Department of Biology, Holland, MI
1998 - 2002 Webmaster, Hope College Department of Biology, Holland, MI
2001 - 2002 Department Representative, University of Florida Graduate Student Council, Gainesville, FL
2001 - 2004 Website design team, University of Florida Department of Pharmacodynamics, Gainesville, FL
2005 - 2006 Congregational Council (Secretary, 2006), University Lutheran Church, Gainesville, FL
2015 University of Iowa / Fraternal Order of Eagles' Diabetes Research Center representative to, National FOE Convention, Milwaukee, WI
2015 Community science outreach, Walcott, IA Lion's Club
2016 Represented Diabetes Research Center, and presented ongoing research to, Missouri / Iowa / Nebraska / Kansas / Dakotas chapter of the Fraternal Order of Eagles' (FOE MINK), Omaha, NE
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Burnatowska-Hledin M, Zeneberg A, roulo A, Grobe JL, Zhao P, Lelkes PI, Clare P, Barney C. Expression of VACM-1 protein in cultured rat adrenal endothelial cells is linked to the cell cycle, Endothelium. 2001;8(1):49-63. PMID:11409851.
2. Barney CC, Kurylo DM, Grobe JL. Thermal dehydration-induced thirst in lithium-treated rats, Pharmacol Biochem Behav. 2003 May;75(2):341-347. PMID:12873625.
3. Grobe JL, Katovich M, Rowland N. Role of angiotensin II in the subfornical organ in the pharmacological actions of ethanol, Alcohol and Alcoholism. 2004 September;39(5):410-417. PMID:15289207.
4. Huentelman MJ, Grobe JL, Vazquez J, Stewart JM, Mecca AP, Katovich MJ, Ferrario CM, Raizada MK. Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats, Exp Physiol. 2005 September;90(5):783-790. PMID:16049057.
5. Grobe JL, Katovich MJ. Alterations in aortic vascular reactivity to angiotensin 1-7 in 17-beta-estradiol-treated female SD rats, Regul Pept. 2006 January 15;133(1-3):62-67. PMID:16219374.
6. Grobe JL, Mecca AP, Mao H, Katovich MJ. Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension, Am J Physiol Heart Circ Physiol. 2006 June;290(6):H2417-H2423. PMID:16415071.
7. Li H, Gao Y, Grobe JL, Raizada MK, Katovich MJ, Sumners C. Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor, Am J Physiol Heart Circ Physiol. 2007 February;2992(2):H727-H735. PMID:17085538.
8. Grobe JL, Mecca AP, Lingis M, Shenoy V, Bolton TA, Machado JM, Speth RC, Raizada MK, Katovich MJ. Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7), Am J Physiol Heart Circ Physiol. 2007 February;292(2):H736-H742. PMID:17098828.
9. Grobe JL, Der Sarkissian S, Stewart JM, Meszaros JG, Raizada MK, Katovich MJ. ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts, Clin Sci (Lond). 2007 October;113(8):357-364. PMID:17600530.
10. Der Sarkissian S, Grobe JL, Yuan L, Narielwala DR, Walter GA, Katovich MJ, Raizada MK. Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology, Hypertension. 2008 March;51(3):712-718. PMID:18250366. PMCID: PMC Journal - In Process.
11. Grobe JL, Xu D, Sigmund CD. An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy, Physiology (Bethesda). 2008 August;23:187-193. PMID:18697992. PMCID: 2538674.
12. Shenov V, Grobe JL, Qi Y, Ferreira AJ, Fraga-Silva RA, Collamat G, Bruce E, Katovich MJ. 17beta-Estradiol modulates local cardiac renin-angiotensin system to prevent cardiac remodeling in the DOCA-salt model of hypertension in rats, Peptides. 2009 December;30(12):2309-2315. PMID:19747516. PMCID: PMC Journal - In Process.
13. Xu D, Borges GR, Grobe JL, Pelham CJ, Yang B, Sigmund CD. Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin, Hypertension. 2009 December;54(6):1240-1247. PMID:19822797. PMCID: 2783841. (Editoral Commentary Precedes Paper; 54(6):1216-1217, 2009)
14. Grobe JL, Grobe CL, Beltz TG, Westphal SG, Morgan DA, Xu D, de Lange WJ, Li H, Sakai K, Thedens DR, Cassis LA, Rahmouni K, Mark AL, Johnson AK, Sigmund CD. The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance, Cell Metabolism. 2010 November 3;12(5):431-442. PMID:21035755. PMCID: 2994017.
15. Grobe JL, Dickson ME, Park S, Davis DR, Born EJ, Sigmund CD. Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice, Hypertension. 2010 November;56(5):981-987. PMID:20823378. PMCID: 2959143.
16. Xu D, Borges GR, Davis DR, Agassandian K, Sequeira Lopez ML, Gomez RA, Cassell MD, Grobe JL, Sigmund CD. Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism, Physiol Genomics. 2011 March 29;43(6):286-294. PMID:21189370. PMCID: 3068515.
17. Grobe JL, Buehrer BA, Hilzendeger AM, Liu X, Davis DR, Xu D, Sigmund CD. Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice, Hypertension. 2011 March;57[Part 2}(3):600-607. PMID:21263123. PMCID: 3144490.
18. Li H, Weatherford ET, Davis DR, Keen HL, Grobe JL, Daugherty A, Cassis LA, Allen AM, Sigmund CD. Renal proximal tubule angiotensin AT1A receptors regulate blood pressure, Am J Physiol Regul Integr Comp Physiol. 2011 October;301(4):R1067-R1077. PMID:21753145. PMCID: 3197336.
19. Hilzendeger AM, Morgan DA, Brooks L, Dellsperger D, Liu X, Grobe JL, Rahmouni K, Sigmund CD, Mark AL. A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity, Am J Physiol Heart Circ Physiol. 2012 July 15;303(2):H197-H206. PMID:22610169. PMCID: 3404702.
20. Pelham CJ, Ketsawatsomkron P, Groh S, Grobe JL, de Lange WJ, Ibeawuchi S-RC, Keen HL, Weatherford ET, Faraci FF, Sigmund CD. Cullin-3 Regulates Vascular Smooth Muscle Function and Arterial Blood Pressure via PPARI? and RhoA/Rho-Kinase, Cell Metab. 2012 October 3;16(4):462-472. PMID:23040068. PMCID: 3474846.
21. Ketsawatsomkron P, Lorca RA, Keen HL, Weatherford ET, Liu X, Pelham Cj, Grobe JL, Faraci FM, England SK, Sigmund CD. PPARI? regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity, Circ Res. 2012 November 9;111(11):1446-1458. PMID:22962432. PMCID: 3494760.
22. Grobe JL, Rahmouni K, Liu X, Sigmund CD. Metabolic rate regulation by the renin-angiotensin system: brain vs. body, Pflugers Arch - European J of Physiology. 2013 January;465(1):167-175. PMID:22491893. PMCID: 3569511.
23. Hilzendeger AM, Cassell MD, Davis DR, Stauss HM, Mark AL, Grobe JL, Sigmund CD. Angiotensin Type 1a Receptors in the Subfornical Organ Are Required for Deoxycorticosterone Acetate-Salt Hypertension, Hypertension. 2013 March 6;61(3):716-722. PMID:23266541. PMCID: 3573251.
24. Littlejohn NK, Siel Jr. RB, Ketsawatsomkron P, Pelham CJ, Pearson NA, Hilzendeger AM, Buehrer BA, Weidemann BJ, Li H, Davis DR, Thompson AP, Liu X, Cassell MD, Sigmund CD, Grobe JL. Hypertension in Mice with Transgenic Activation of the Brain Renin-Angiotensin System is Vasopressin-Dependent, Am J Physiol: Regul Integr Comp Physiol. 2013 May 15;304(10):R818-R828. PMID:23535460. PMCID: 3652167.
25. Burnett CM, Grobe JL. Direct calorimetry identifies deficiencies in respirometry for the determination of resting metabolic rate in C57Bl/6 and FVB mice, Am J Physiol: Endocrinol Metab. 2013 October 1;305(7):E916-E924. PMID:23964071. PMCID: 3798702.
26. Li W, Peng H, Mehaffey Ep, Kimball CD, Grobe JL, van Gool JM, Sullivan MN, Earley S, Danser AH, Ichihara A, Feng Y. Neuron-Specific (Pro)renin Receptor Knockout Prevents the Development of Salt-Sensitive Hypertension, Hypertension. 2013;63(2):316-323. PMID:24246383. PMCID: 3947277.
27. Carrillo-Supulveda MA, Keen HL, Davis DR, Grobe JL, Sigmund CD. Role of vascular smooth muscle PPARI? in regulating AT1 receptor signaling and angiotensin II-dependent hypertension, PLoS One. 2014 April 14;9(8):e103786. PMID:25122005. PMCID: 4133177.
28. Coble JP, Cassell MD, Davis DR, Grobe JL, Sigmund CD. Activation of the renin-angiotensin system, specifically in the subfornical organ is sufficient to induce fluid intake, Am J Physiol Regul Integr Comp Physiol. 2014 April 15;307(4):R376-R386. PMID:24965793. PMCID: 4137154.
29. Coble JP, Johnson RF, Cassell MD, Johnson AK, Grobe JL, Sigmund CD. Activity of protein kinase C-I? within the subfornical organ is necessary for fluid intake in response to brain angiotensin, Hypertension. 2014 July;64(1):141-148. PMID:24777977. PMCID: 4057298.
30. Shi P, Grobe JL, Desland FA, Zhou G, Shen XZ, Shan Z, Liu M, Raizada MK, Sumners C. Direct pro-inflammatory effects of prorenin on microglia, PLoS One. 2014 October 10;9(10):e92937. PMID:25302502. PMCID: 4193744.
31. Santillan MK, Santillan DA, Scroggins SM, Min JY, Sandgren JA, Pearson NA, Leslie KK, Hunter SK, Zamba GK, Gibson-Corley KN, Grobe JL. Vasopressin in Preeclampsia: A Novel Very-Early Human Pregnancy Biomarker and Clinically-Relevant Mouse Model, Hypertension. 2014 October;64(4):852-859. PMID:25001273. PMCID: 4162750.
32. Ye Y, Sun Z, Guo A, Song LS, Grobe JL, Chen S. Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia., Cell Signal. 2014 November;26(11):2514-2520. PMID:25093805. PMCID: 4160384.
33. Burnett CM, Grobe JL. Dietary effects on resting metabolic rate in C57BL/6 mice are differentially detected by indirect (O2/CO2 respirometry) and direct calorimetry, Molecular Metabolism. 2014;3:460-464. PMID:24944905. PMCID: 4060218.
34. Fink BD, Herlein JA, Guo DF, Kulkarni C, Weidemann BJ, Yu L, Grobe JL, Rahmouni K, Kerns RJ, Sigmund CD. A mitochondrial-targeted coenzyme q analog prevents weight gain and ameliorates hepatic dysfunction in high-fat-fed mice, J Pharmacol Exp Ther. 2014 December;351(3):699-708. PMID:25301169. PMCID: 4244581.
35. Santillan MK, Pelham CJ, Ketsawatsomkron P, Santillan DA, Davis DR, Devor EJ, Gibson-Corley KN, Scroggins SM, Grobe JL, Yang B, Hunter SK, Sigmund CD. Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes., Physiological reports. 2015 January 19;3(1):e12257. PMID:25602015. PMCID: 4387753.
36. Jo F, Jo H, Hilzendeger AM, Thompson AP, Cassell MD, Rutkowski DT, Davisson RL, Grobe JL, Sigmund CD. Brain endoplasmic reticulum stress mechanistically distinguishes the saline-intake and hypertensive response to deoxycorticosterone acetate-salt., Hypertension (Dallas, Tex. : 1979). 2015 June 1;65(6):1341-8. PMID:25895586. PMCID: 4433403.
37. Weidemann BJ, Voong S, Morales-Santiago FI, Kahn MZ, Ni J, Littlejohn NK, Claflin KE, Burnett CM, Pearson NA, Lutter ML, Grobe JL. Dietary Sodium Suppresses Digestive Efficiency via the Renin-Angiotensin System, Scientific Reports. 2015 June 11;5:11123. PMID:26068176. PMCID: 4464075.
38. Bahr SM, Weidemann BJ, Castro AN, Walsh JW, deLeon O, Burnett CM, Pearson NA, Murry DJ, Grobe JL, Kirby JR. Risperidone-induced weight gain is mediated through shifts in the gut microbiome and suppression of energy expenditure., EBioMedicine. 2015 November 1;2(11):1725-34. PMID:26870798. PMCID: 4740326.
39. Barney CC, Schanhals EM, Grobe JL, Andresen BT, Traver M. Heat acclimation and thirst in rats, Physiological reports. 2015 December 1;3(12):e12642. PMID:26702076. PMCID: 4760436.
40. Ketsawatsomkron P, Keen HL, Davis DR, Lu KT, Stump M, De Silva TM, Hilzendeger AM, Grobe JL, Faraci FM, Sigmund CD. Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-I? Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension., Hypertension (Dallas, Tex. : 1979). 2016 January 1;67(1):214-22. PMID:26597823. PMCID: 4679422.
41. Guo DF, Cui H, Zhang Q, Morgan DA, Thedens DR, Nishimura D, Grobe JL, Sheffield VC, Rahmouni K. The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane., PLoS genetics. 2016 February 29;12(2):e1005890. PMID:26926121. PMCID: 4771807.
42. Muta K, Morgan DA, Grobe JL, Sigmund CD, Rahmouni K. mTORC1 Signaling Contributes to Drinking But Not Blood Pressure Responses to Brain Angiotensin II., Endocrinology. 2016 August 1;157(8):3140-8. PMID:27254006. PMCID: 4967111.
43. Littlejohn NK, Keen HL, Weidemann BJ, Claflin KE, Tobin KV, Markan KR, Park S, Naber MC, Gourronc FA, Pearson NA, Liu X, Morgan DA, Klingelhutz AJ, Potthoff MJ, Rahmouni K, Sigmund CD, Grobe JL. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor., Cell reports. 2016 August 9;16(6):1548-60. PMID:27477281. PMCID: 4981564.
44. Boi SK, Buchta CM, Pearson NA, Francis MB, Meyerholz DK, Grobe JL, Norian LA. Obesity alters immune and metabolic profiles: New insight from obese-resistant mice on high-fat diet., Obesity (Silver Spring, Md.). 2016 October 1;24(10):2140-9. PMID:27515998. PMCID: 5039085.
45. Shinohara K, Liu X, Morgan DA, Davis DR, Sequeira-Lopez ML, Cassell MD, Grobe JL, Rahmouni K, Sigmund CD. Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension., Hypertension (Dallas, Tex. : 1979). 2016 December 1;68(6):1385-1392. PMID:27754863. PMCID: 5159235.
46. Claflin KE, Sandgren JA, Lambertz AM, Weidemann BJ, Littlejohn NK, Burnett CM, Pearson NA, Morgan DA, Gibson-Corley KN, Rahmouni K, Grobe JL. Angiotensin AT1A receptors on leptin receptor-expressing cells control resting metabolism, The Journal of Clinical Investigation. 2017 April 3;127(4):1414-1424. PMID:28263184. PMCID: 5373887.
47. Agassandian K, Grobe JL, Liu X, Agassandrian M, Thompson AP, Sigmund CD, Cassell MD. Evidence for intraventricular secretion of angiotensinogen and angiotensin by the subfornical organ using transgenic mice, Am J Physiol Regul Integr Comp Physiol. 2017;312(6):R973-R981. PMID:28490451. PMCID: 5495920.
48. Srisai D, Yin TC, Lee AA, Rouault AAJ, Pearson NA, Grobe JL, Sebag JA. MRAP2 regulates ghrelin receptor signaling and hunger sensing., Nature communications. 2017 September 28;8(1):713. PMID:28959025. PMCID: 5620068.
49. Shinohara K, Nakagawa P, Gomez J, Morgan DA, Littlejohn NK, Folchert MD, Weidemann BJ, Liu X, Walsh SA, Ponto LL, Rahmouni K, Grobe JL, Sigmund CD. Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism., Hypertension (Dallas, Tex. : 1979). 2017 November 1;70(5):990-997. PMID:28874461. PMCID: 5679092.
50. Sandgren JA, Linggonegoro DW, Zhang SY, Sapouckey SA, Claflin KE, Pearson NA, Leidinger MR, Pierce GL, Santillan MK, Gibson-Corley KN, Sigmund CD, Grobe JL. Angiotensin AT1A Receptors Expressed in Vasopressin-Producing Cells of the Supraoptic Nucleus Contribute to the Osmotic Control of Vasopressin., American journal of physiology. Regulatory, integrative and comparative physiology. 2018 January 24;314(6):R770-R780. PMID:29364700. PMCID: PMC6032302.
51. Scroggins SM, Santillan DA, Lund JM, Sandgren JA, Krotz LK, Hamilton WS, Devor EJ, Davis HA, Pierce GL, Gibson-Corley KN, Sigmund CD, Grobe JL, Santillan MK. Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia., Clinical science (London, England : 1979). 2018 February 14;132(3):419-436. PMID:29371289. PMCID: PMC5947858.
52. Sandgren JA, Deng G, Linggonegoro DW, Scroggins SM, Perschbacher KJ, Nair AR, Nishimura TE, Zhang SY, Agbor LN, Wu J, Keen HL, Naber MC, Pearson NA, Zimmerman KA, Weiss RM, Bowdler NC, Usachev YM, Santillan DA, Potthoff MJ, Pierce GL, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL. Arginine Vasopressin Infusion is Sufficient to Model Clinical Features of Preeclampsia in Mice, JCI Insight. 2018 October 4;3(19):99403. PMID:30282823. PMCID: PMC6237463.
53. Ameka M, Markan KR, Morgan DA, BonDurant LD, Idiga SO, Naber MC, Zingman LV, Grobe JL, Rahmouni K, Potthoff MJ. Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure, Scientific Reports. 2019 January 24;9(1):630. PMID:30679672. PMCID: PMC6345819.
54. Soto JE, Burnett CM, Abel ED, Grobe JL. Comparison of The Effects of High Fat Diet on Energy Flux in Mice Using Two Multiplexed Metabolic Phenotyping Systems, Obesity (Silver Spring). 2019 May;27(5):793-802. PMID: 30938081. PMCID: PMC6478533.
55. Saito K, Davis KC, Morgan DA, Toth BA, Jiang J, Singh U, Berglund ED, Grobe JL, Rahmouni K, Cui H. Celastrol Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions. Diabetes. 2019 Jun;68(6):1210-1220. PMID: 30894367. PMCID: PMC6610022.
56. Nair AR, Silva SD Jr, Agbor LN, Wu J, Nakagawa P, Mukohda M, Lu KT, Sandgren JA, Pierce GL, Santillan MK, Grobe JL, Sigmund CD. Endothelial PPARI? (Peroxisome Proliferator-Activated Receptor-I?) Protects From Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born From Pregnancies Complicated by Hypertension. Hypertension. 2019 Jul;74(1):173-183. PMID: 31104564. PMCID: PMC6561821.
57. Guo DF, Lin Z, Wu Y, Searby C, Thedens DR, Richerson GB, Usachev YM, Grobe JL, Sheffield VC, Rahmouni K. The BBSome in POMC and AgRP Neurons Is Necessary for Body Weight Regulation and Sorting of Metabolic Receptors. Diabetes. 2019 Aug;68(8):1591-1603. PMID: 31127052. PMCID: PMC6692817.
58. Perschbacher KJ, Deng G, Sandgren JA, Walsh JW, Witcher PC, Sapouckey SA, Owens CE, Zhang SY, Scroggins SM, Pearson NA, Devor EJ, Sebag JA, Pierce GL, Fisher RA, Kwitek AE, Santillan DA, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL. Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice. Hypertension. 2020 02;75(2):569-579. PMCID: PMC7027931
59. Segar JL, Grobe CC, Grobe JL. Fetal storage of osmotically inactive sodium. Am J Physiol Regul Integr Comp Physiol. 2020 03 01;318(3):R512-R514. PMCID: PMC7099460
60. Sapouckey SA, Morselli LL, Deng G, Patil CN, Balapattabi K, Oliveira V, Claflin KE, Gomez J, Pearson NA, Potthoff MJ, Gibson-Corley KN, Sigmund CD, Grobe JL. Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or agouti-related peptide. Am J Physiol Regul Integr Comp Physiol. 2020 05 01;318(5):R855-R869. PMCID: PMC7272763
61. Lueschow SR, Kern SL, Gong H, Grobe JL, Segar JL, Carlson SJ, McElroy SJ. Feeding Formula Eliminates the Necessity of Bacterial Dysbiosis and Induces Inflammation and Injury in the Paneth Cell Disruption Murine NEC Model in an Osmolality-Dependent Manner. Nutrients. 2020 Mar 26;12(4). PMCID: PMC7230818
62. Wu J, Agbor LN, Fang S, Mukohda M, Nair AR, Nakagawa P, Sharma A, Morgan DA, Grobe JL, Rahmouni K, Weiss RM, McCormick JA, Sigmund CD. Failure to vasodilate in response to salt loading blunts renal blood flow and causes salt-sensitive hypertension. Cardiovasc Res. 2021 01 01;117(1):308-319. PMCID: PMC7797211
63. Deng G, Morselli LL, Wagner VA, Balapattabi K, Sapouckey SA, Knudtson KL, Rahmouni K, Cui H, Sigmund CD, Kwitek AE, Grobe JL. Single-Nucleus RNA Sequencing of the Hypothalamic Arcuate Nucleus of C57BL/6J Mice After Prolonged Diet-Induced Obesity. Hypertension. 2020 08;76(2):589-597. PMCID: PMC7347451
64. Nakagawa P, Nair AR, Agbor LN, Gomez J, Wu J, Zhang SY, Lu KT, Morgan DA, Rahmouni K, Grobe JL, Sigmund CD. Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage. Hypertension. 2020 08;76(2):468-477. PMCID: PMC7347438
65. Ono-Moore KD, Rutkowsky JM, Pearson NA, Williams DK, Grobe JL, Tolentino T, Lloyd KCK, Adams SH. Coupling of energy intake and energy expenditure across a temperature spectrum: impact of diet-induced obesity in mice. Am J Physiol Endocrinol Metab. 2020 09 01;319(3):E472-E484. PMCID: PMC7509245
66. Nuckols VR, Holwerda SW, Luehrs RE, DuBose LE, Stroud AK, Brandt D, Betz AM, Fiedorowicz JG, Scroggins SM, Santillan DA, Grobe JL, Sigmund CD, Santillan MK, Pierce GL. Beat-to-Beat Blood Pressure Variability in the First Trimester Is Associated With the Development of Preeclampsia in a Prospective Cohort: Relation With Aortic Stiffness. Hypertension. 2020 12;76(6):1800-1807. PMCID: PMC7706825
67. Segar JL, Balapattabi K, Reho JJ, Grobe CC, Burnett CML, Grobe JL. Quantification of body fluid compartmentalization by combined time-domain nuclear magnetic resonance and bioimpedance spectroscopy. Am J Physiol Regul Integr Comp Physiol. 2021 01 01;320(1):R44-R54. PMCID: PMC7847054
68. Ye Y, Abu El Haija M, Morgan DA, Guo D, Song Y, Frank A, Tian L, Riedl RA, Burnett CML, Gao Z, Zhu Z, Shahi SK, Zarei K, Couvelard A, Pot?? N, Ribeiro-Parenti L, Bado A, Noureddine L, Bellizzi A, Kievit P, Mangalam AK, Zingman LV, Le Gall M, Grobe JL, Kaplan LM, Clegg D, Rahmouni K, Mokadem M. Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass. Cell Rep. 2020 10 27;33(4):108270. PMCID: PMC7660289
69. Zanaty M, Seara FAC, Nakagawa P, Deng G, Mathieu NM, Balapattabi K, Karnik SS, Grobe JL, Sigmund CD. I?-Arrestin-Biased Agonist Targeting the Brain AT<sub>1</sub>R (Angiotensin II Type 1 Receptor) Increases Aversion to Saline and Lowers Blood Pressure in Deoxycorticosterone Acetate-Salt Hypertension. Hypertension. 2021 02;77(2):420-431. PMCID: PMC7855825
70. Segar JL, Grobe CC, Balapattabi K, Ritter ML, Reho JJ, Grobe JL. Dissociable effects of dietary sodium in early life upon somatic growth, fluid homeostasis, and spatial memory in mice of both sexes. Am J Physiol Regul Integr Comp Physiol. 2021 04 01;320(4):R438-R451. PMCID: PMC8238146
71. Gumusoglu SB, Chilukuri ASS, Hing BWQ, Scroggins SM, Kundu S, Sandgren JA, Santillan MK, Santillan DA, Grobe JL, Stevens HE. Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model. Transl Psychiatry. 2021 01 28;11(1):79. PMCID: PMC7844013
72. Wu J, Fang S, Lu KT, Wackman K, Schwartzman ML, Dikalov SI, Grobe JL, Sigmund CD. EP3 (E-Prostanoid 3) Receptor Mediates Impaired Vasodilation in a Mouse Model of Salt-Sensitive Hypertension. Hypertension. 2021 04;77(4):1399-1411. PMCID: PMC7946772
73. Rouabhi M, Guo DF, Morgan DA, Zhu Z, L??pez M, Zingman L, Grobe JL, Rahmouni K. BBSome ablation in SF1 neurons causes obesity without comorbidities. Mol Metab. 2021 06;48:101211. PMCID: PMC8065214
74. Wagner VA, Clark KC, Carrillo-S?!enz L, Holl KA, Velez-Bermudez M, Simonsen D, Grobe JL, Wang K, Thurman A, Solberg Woods LC, Lehmler HJ, Kwitek AE. Bisphenol F Exposure in Adolescent Heterogeneous Stock Rats Affects Growth and Adiposity. Toxicol Sci. 2021 05 27;181(2):246-261. PMCID: PMC8163043
75. Riedl RA, Burnett CML, Pearson NA, Reho JJ, Mokadem M, Edwards RA, Kindel TL, Kirby JR, Grobe JL. Gut Microbiota Represent a Major Thermogenic Biomass. Function (Oxf). 2021;2(3):zqab019. PMCID: PMC8055641
76. Segar JL, Grobe CC, Grobe JL. Maturational changes in sodium metabolism in periviable infants. Pediatr Nephrol. 2021 11;36(11):3693-3698. PMCID: PMC8815317
77. De Silva TM, Modrick ML, Grobe JL, Faraci FM. Activation of the Central Renin-Angiotensin System Causes Local Cerebrovascular Dysfunction. Stroke. 2021 07;52(7):2404-2413. PMCID: PMC8262118
78. Nakagawa P, Gomez J, Lu KT, Grobe JL, Sigmund CD. Studies of salt and stress sensitivity on arterial pressure in renin-b deficient mice. PLoS One. 2021;16(7):e0250807. PMCID: PMC8318244
79. Xu H, Thomas MJ, Kaul S, Kallinger R, Ouweneel AB, Maruko E, Oussaada SM, Jongejan A, Cense HA, Nieuwdorp M, Serlie MJ, Goldberg IJ, Civelek M, Parks BW, Lusis AJ, Knaack D, Schill RL, May SC, Reho JJ, Grobe JL, Gantner B, Sahoo D, Sorci-Thomas MG. Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake. Arterioscler Thromb Vasc Biol. 2021 11;41(11):2708-2725. PMCID: PMC8551036
80. Ziegler AA, Grobe CC, Reho JJ, Jensen ES, Thulin JD, Segar JL, Grobe JL. Short-term Housing in Metabolic Caging on Measures of Energy and Fluid Balance in Male C57BL/6J Mice ( <i>Mus musculus</i>). J Am Assoc Lab Anim Sci. 2022 Mar 01;61(2):132-139. PMCID: PMC8956215
81. Herz H, Song Y, Ye Y, Tian L, Linden B, Abu El Haija M, Chu Y, Grobe JL, Lengeling RW, Mokadem M. NSAID-Induced Enteropathy Affects Regulation of Hepatic Glucose Production by Decreasing GLP-1 Secretion. Nutrients. 2021 Dec 28;14(1). PMCID: PMC8746549
82. Lozada-Fern?!ndez VV, deLeon O, Kellogg SL, Saravia FL, Hadiono MA, Atkinson SN, Grobe JL, Kirby JR. Nicotinamide Riboside-Conditioned Microbiota Deflects High-Fat Diet-Induced Weight Gain in Mice. mSystems. 2022 02 22;7(1):e0023021. PMCID: PMC8788325
83. Reho JJ, Nakagawa P, Mouradian GC Jr, Grobe CC, Saravia FL, Burnett CML, Kwitek AE, Kirby JR, Segar JL, Hodges MR, Sigmund CD, Grobe JL. Methods for the Comprehensive <i>in vivo</i> Analysis of Energy Flux, Fluid Homeostasis, Blood Pressure, and Ventilatory Function in Rodents. Front Physiol. 2022;13:855054. PMCID: PMC8914175
84. Patil CN, Ritter ML, Wackman KK, Oliveira V, Balapattabi K, Grobe CC, Brozoski DT, Reho JJ, Nakagawa P, Mouradian GC Jr, Kriegel AJ, Kwitek AE, Hodges MR, Segar JL, Sigmund CD, Grobe JL. Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet. Am J Physiol Regul Integr Comp Physiol. 2022 06 01;322(6):R467-R485. PMCID: PMC9054347
85. Oliveira V, Riedl RA, Claflin KE, Mathieu NM, Ritter ML, Balapattabi K, Wackman KK, Reho JJ, Brozoski DT, Morgan DA, Cui H, Rahmouni K, Burnett CML, Nakagawa P, Sigmund CD, Morselli LL, Grobe JL. Melanocortin MC<sub>4</sub>R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain. Physiol Genomics. 2022 06 01;54(6):196-205. PMCID: PMC9131927
86. Wu J, Fang S, Lu KT, Kumar G, Reho JJ, Brozoski DT, Otanwa AJ, Hu C, Nair AR, Wackman KK, Agbor LN, Grobe JL, Sigmund CD. Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension. Function (Oxf). 2022;3(3):zqac017. PMCID: PMC9045850
87. Clark KC, Wagner VA, Holl KL, Reho JJ, Tutaj M, Smith JR, Dwinell MR, Grobe JL, Kwitek AE. Body Composition and Metabolic Changes in a Lyon Hypertensive Congenic Rat and Identification of <i>Ercc6l2</i> as a Positional Candidate Gene. Front Genet. 2022;13:903971. PMCID: PMC9263446
88. Oliveira V, Reho JJ, Balapattabi K, Ritter ML, Mathieu NM, Opichka MA, Lu KT, Grobe CC, Silva SD Jr, Wackman KK, Nakagawa P, Segar JL, Sigmund CD, Grobe JL. Chronic intracerebroventricular infusion of angiotensin II causes dose- and sex-dependent effects upon intake behaviors and energy homeostasis in C57BL/6J mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jul 11.
89. Mouradian GC Jr, Liu P, Nakagawa P, Duffy E, Gomez Vargas J, Balapattabi K, Grobe JL, Sigmund CD, Hodges MR. Patch-to-Seq and Transcriptomic Analyses Yield Molecular Markers of Functionally Distinct Brainstem Serotonin Neurons. Front Synaptic Neurosci. 2022;14:910820. PMCID: PMC9280690
 
Books, Chapters, and Reviews
1. Katovich MJ, Grobe JL, Raizada MK. Gene therapy for hypertension: current targets and consideration of novel targets. In: Cardiovascular Genomics. Humana Press. 2005. p. 213-246.
2. Katovich MJ, Grobe JL, Huentelman M, Raizada MK. Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension, Exp Physiol. 2005 May;90(3):299-305. PMID:15640278.
3. Katovich MJ, Grobe JL, Raizada MK. Angiotensin-(1-7) as an antihypertensive, antifibrotic target, Curr Hypertens Rep. 2008 June;10(3):227-232. PMID:18765095.
4. Grobe JL, Venegas-Pont M, Sigmund CD, Ryan MJ. PPARgamma differentially regulates energy substrate handling in brown vs. white adipose: focus on "The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake"., Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1325-R1326. PMCID: 3597227.
5. Grobe JL, Rahmouni K. Editoral Focus: A fat contribution to RAS activation and blood pressure control: evidence from angiotensinogen conditional null mice. Focus on: "Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice, Am J Physiol: Regul Integr Comp Physiol. 2012 January 15;302(2):R242-R243. PMID:22071163.
6. Grobe JL, Rahmouni K. The adipose/circulating renin-angiotensin system cross-talk enters a new dimension, Hypertension. 2012 December;60(6):1389-1390. PMID:23108659. PMCID: 3959780.
7. Grobe JL, Sigmund CD. Another reason to eat your greens: cardiopulmonary protection by dietary delivery of angiotensin-converting enzyme-2 and angiotensin-(1-7) made in plants, Hypertension. 2014 December;64(6):1182-1183. PMID:25225201.
8. Coble JL, Grobe JL, Johnson AK, Sigmund CD. Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ, Am J Physiol Regul Integr Comp Physiol. 2015 February 15;308(4):R238-R249. PMID:25519738. PMCID: 4347751.
9. Sandgren JA, Scroggins SM, Santillan DA, Devor EJ, Gibson-Corley KN, Pierce GL, Sigmund CD, Santillan MK, Grobe JL. Vasopressin: The Missing Link for Preeclampsia?, American journal of physiology. Regulatory, integrative and comparative physiology. 2015 March 25:ajpregu.00073.2015. PMID:25810383. PMCID: 4666952.
10. Claflin KE, Grobe JL. Control of energy balance by the brain renin-angiotensin system, Current hypertension reports. 2015 May 1;17(5):38. PMID:25833461.
11. Littlejohn NK, Grobe JL. Opposing tissue-specific roles of angiotensin in the pathogenesis of obesity, and implications for obesity-related hypertension., American journal of physiology. Regulatory, integrative and comparative physiology. 2015 December 15;309(12):R1463-73. PMID:26491099. PMCID: 4698411.
12. Muntner P, Becker RC, Calhoun D, Chen D, Cowley, Jr AW, Flynn JT, Grobe JL, Kidambi S, Kotchen TA, Lackland DT, Leslie KK, Li Y, Liang M, Lloyd A, Mattson DL, Mendizabal B, Mitsnefes M, Nair A, Pierce GL, Pollock JS, Safford MM, Santillan MK, Sigmund CD, Thomas SJ, Urbina EM. Introduction to the American Heart Association's Hypertension Strategically Focused Research Network., Hypertension (Dallas, Tex. : 1979). 2016 April 1;67(4):674-80. PMID:26902490. PMCID: 5135412.
13. Sandgren JA, Santillan MK, Grobe JL. Breaking a Mother's Heart: Circulating Antiangiogenic Factors and Hypertension During Pregnancy Correlate With Specific Cardiac Dysfunctions., Hypertension (Dallas, Tex. : 1979). 2016 June 1;67(6):1119-20. PMID:27113050. PMCID: 4865412.
14. Riedl RA, Atkinson SN, Burnett CML, Grobe JL, Kirby JR. The Gut Microbiome, Energy Homeostasis, and Implications for Hypertension., Current hypertension reports. 2017 April 1;19(4):27. PMID:28316052. PMCID: 5773096.
15. Grobe JL. Comprehensive Assessments of Energy Balance in Mice. The Renin-Angiotensin-Aldosterone System: Methods and Protocols. Methods Molecular Biology Series. Springer. 2017. p. 123-146. PMID:28500600. PMCID: 5582947.
16. Sapouckey SA, Deng G, Sigmund CD, Grobe JL. Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism., Physiological genomics. 2017 December 1;49(12):722-732. PMID:28986397. PMCID: PMC5814669.
17. Morselli LL, Claflin KE, Cui H, Grobe JL. Control of Energy Expenditure by AgRP Neurons of the Arcuate Nucleus: Neurocircuitry, Signaling Pathways, and Angiotensin., Current hypertension reports. 2018 March 19;20(3):25. PMID:29556733. PMCID: PMC5882211.
18. Perschbacher KJ, Deng G, Fisher RA, Gibson-Corley KN, Santillan MK, Grobe JL. Regulators of G-Protein Signaling in Cardiovascular Function During Pregnancy., Physiological genomics. 2018 April 27;50(8):590-604. PMID:29702036. PMCID: PMC6139632.
19. Deng G, Grobe JL. The renin-angiotensin system in the arcuate nucleus controls resting metabolic rate, Current Opinion in Nephrology. 2018 December 10. PMID:30531199. PMCID: PMC6366639.
20. Nakagawa P, Gomez J, Grobe JL, Sigmund CD. The Renin-Angiotensin System in the Central Nervous System and Its Role in Blood Pressure Regulation. Curr Hypertens Rep. 2020 01 10;22(1):7. PMCID: PMC7101821
21. Sigmund CD, Grobe JL. A colorful view of the brain renin-angiotensin system. Hypertens Res. 2020 04;43(4):357-359. PMCID: PMC7107486
22. Oliveira V, Kwitek AE, Sigmund CD, Morselli LL, Grobe JL. Recent Advances in Hypertension: Intersection of Metabolic and Blood Pressure Regulatory Circuits in the Central Nervous System. Hypertension. 2021 04;77(4):1061-1068. PMCID: PMC7990288
23. Santillan MK, Becker RC, Calhoun DA, Cowley AW, Flynn JT, Grobe JL, Kotchen TA, Lackland DT, Leslie KK, Liang M, Mattson DL, Meyers KE, Mitsnefes MM, Muntner PM, Pierce GL, Pollock JS, Sigmund CD, Thomas SJ, Urbina EM, Kidambi S. Team Science: American Heart Association's Hypertension Strategically Focused Research Network Experience. Hypertension. 2021 06;77(6):1857-1866. PMCID: PMC8986150
24. Deng Y, Deng G, Grobe JL, Cui H. Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control. Front Physiol. 2021;12:691226. PMCID: PMC8274634
25. Opichka MA, Rappelt MW, Gutterman DD, Grobe JL, McIntosh JJ. Vascular Dysfunction in Preeclampsia. Cells. 2021 11 06;10(11). PMCID: PMC8616535
26. Grobe JL, Potthoff MJ. CNS Regulation of Energy Balance. In: Handbook of Obesity. CRC Press of the Taylor & Francis Group. 2022. Chapter 21.
 
Patents
1. Grobe JL, Santillan MK, Santillan DA, inventors; Therapeutic strategies for the treatment of preeclampsia. United States Patent Application #20180228806; PCT/US2014/015631. United States Patent #9,937,182. (April 10, 2018).
2. Grobe JL, Santillan MK, inventors; Diagnostic tools to predict onset of preeclampsia / Method using copeptin to predict onset of preeclampsia. United States Patent Application #20150377876; PCT/US2014/015627. European Patent #2954324 (July 31, 2019).
3. Grobe JL, Santillan MK, Santillan DA, inventors; Detection of predictors of preeclampsia. United States Patent Application #20200124612; PCT/US2018/027152, Int'l filing date 11 April 2018 / priority date 11 April 2017.
4. Grobe JL, Santillan MK, Santillan DA, inventors; Early prediction of preeclampsia. United States Patent Application #20170315130. US15/583,400, priority date 01 May 2017.