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CURRICULUM VITAE

Justin L. Grobe PhD
Professor
Department of Physiology
& Department of Biomedical Engineering;
Butenhoff Family Professor of Cardiovascular Research;
Director, Comprehensive Rodent Metabolic Phenotyping Core;
Vice-Chair, Institutional Animal Care & Use Committee

ORCiD: 0000-0001-9737-0873
OFFICE ADDRESS:
Health Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226
Phone: 414-955-4981
Email: jgrobe@mcw.edu

EDUCATION:
08/1997 - 05/2001 BS (Biology) + BA (Chemistry); Mentor: Christopher C. Barney, PhD, Hope College, Holland, MI
08/2001 - 05/2006 PhD (Pharmacodynamics); Mentor: Michael J. Katovich, PhD, University of Florida, Gainesville, FL

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
05/2006 - 09/2006 Postdoctoral Fellow (laboratory of Mohan K. Raizada, PhD), Department of Physiology & Functional Genomics, College of Medicine, University of Florida, Gainesville, FL
09/2006 - 06/2010 Postdoctoral Fellow (laboratory of Curt D. Sigmund, PhD), Department of Internal Medicine, Roy J. & Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA

FACULTY APPOINTMENTS:
07/2010 - 05/2012 Associate (Instructor equivalent), Department of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA
06/2012 - 06/2017 Assistant Professor (Tenure Track), Department of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA
07/2017 - 06/2019 Associate Professor with Tenure, Department of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA
07/2019 - 06/2023 Associate Professor with Tenure, Departments of Physiology & Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI
07/2023 - Present Professor with Tenure, Departments of Physiology & Biomedical Engineering, Medical College of Wisconsin

EDUCATIONAL ADMINISTRATIVE APPOINTMENTS:
09/2023 - Present Member, Graduate Committee, Biomedical Engineering, Medical College of Wisconsin

RESEARCH ADMINISTRATIVE APPOINTMENTS:
07/2019 - Present Director, Comprehensive Rodent Metabolic Phenotyping Core, Medical College of Wisconsin, Milwaukee, WI
08/2022 - Present Vice-Chair, Institutional Animal Care & Use Committee (IACUC), Medical College of Wisconsin, Milwaukee, WI

AWARDS AND HONORS:
2001 Departmental Service Award - Department of Biology, Hope College
2001 Frank Patterson Memorial Award - Department of Biology, Hope College
2005 Association for Chemoreception Sciences (AChemS) Conference Travel Award - UF Center for Smell and Taste, University of Florida
2006 First Place, Oral Presentation (Senior Division), 19th Annual Research Showcase, University of Florida College of Pharmacy
2007 Merck New Investigator Award, American Heart Association Council on Hypertension
2007 Clinical Science Young Investigator Award, sponsored by Portland Press, American Physiological Society Cardiovascular Section
2008 Poster Award, Gordon Research Conference: Angiotensin
2008 Research Recognition Award, American Physiological Society Neural Control and Autonomic Regulation Section
2008 Young Investigator Award, Society for Experimental Biology and Medicine
2008 New Investigator Travel Award, American Heart Association Council on Hypertension
2008 Caroline tum Suden / Frances A. Hellebrandt Professional Opportunity Award, American Physiological Society
2009 Carver College of Medicine Health Sciences Research Week Poster Presentation Award, Postdoctoral Fellow Division, University of Iowa
2011 New Investigator of the Month, International Society of Hypertension
2012 Elected to "Fellow of the American Heart Association" (FAHA), American Heart Association Council on Hypertension
2014 Young Scholar Award, American Society of Hypertension
2014 - 2015 Recognized as among top 10 reviewers for journal, Hypertension (journal)
2015 Young Investigator Award , American Physiological Society Water & Electrolyte Homeostasis Section
2015 Harry Goldblatt New Investigator Award, American Heart Association Council on Hypertension
2016 Office of the Vice President for Research & Economic Development Inventor Award, University of Iowa
2016 "Forty Under 40" Award, Cedar Rapids / Iowa City area Corridor Business Journal
2017 Awarded Tenure, University of Iowa
2017 Arthur C. Guyton Award for Excellence in Integrative Physiology, American Physiology Society
2017 Office of the Vice President for Research & Economic Development Inventor Award, University of Iowa
2018 - 2022 Established Investigator Award, American Heart Association
2018 Office of the Vice President for Research & Economic Development Inventor Award, University of Iowa
2018 Outstanding Reviewer Award, Experimental Biology and Medicine (journal)
2019 Awarded Tenure, Medical College of Wisconsin
2021 MCW Outstanding Medical Student Teacher for 2020-2021 (Physiology), Medical College of Wisconsin
2021 Elected to Fellow of the American Physiological Society (FAPS), American Physiological Society
2022 MCW Outstanding Graduate School Educators for 2021-2022 (Physiology), Medical College of Wisconsin
2022 Mid-Career Award for Research Excellence, American Heart Association Council on Hypertension
2023 MCW Outstanding Medical Student Teacher for 2022-2023 (Physiology), Medical College of Wisconsin
2023 MCW Outstanding Graduate School Educators for 2022-2023 (Biostatistics), Medical College of Wisconsin
2024 - Present Butenhoff Family Professorship in Cardiovascular Research

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
1998 - 2001 Beta Beta Beta Undergraduate Biological Honor Society (Hope College)
1999 - Present American Heart Association (member 120721042; elected to Fellow (FAHA) in 2012)
1999 - Present American Physiological Society (member 00033392; elected to Fellow (FAPS) in 2021)
2000 - 2013 Sigma Xi
2005 - 2013 Society for Experimental Biology and Medicine
2011 - 2013 International Society of Hypertension
2013 - Present American Diabetes Association (member 08344175 / 0520608555)
2014 - 2018 American Society for Pharmacology and Experimental Therapeutics (member 49382)
2018 - Present The Obesity Society (member 25073)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorial Board
01/2012 - 12/2024 Hypertension
2015 - 2021 Physiological Genomics (Section Editor)
2018 - Present JAHA: Journal of the American Heart Association (frequent Guest Associate Editor)
2019 - 2021 Biology of Sex Differences
Ad-Hoc Reviewer
2007 - Present Hypertension
2008 - Present American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology
2008 - Present Physiological Genomics
2009 - Present Circulation Research
2009 - Present Biochemical Pharmacology
2009 - Present Obesity
2011 - Present American Journal of Physiology: Heart and Circulatory Physiology
2011 - Present British Journal of Pharmacology
2011 - Present Regulatory Peptides
2011 - Present International Journal of Hypertension
2011 - Present Cellular Physiology and Biochemistry
2012 - Present Clinical and Experimental Pharmacology and Physiology
2012 - Present Journal of Applied Physiology
2012 - Present Journal of Cardiovascular Pharmacology and Therapeutics
2012 - Present PLOS ONE
2013 - Present Acta Physiologica
2013 - Present Hypertension Research
2013 - Present Cellular and Molecular Neurobiology
2013 - Present Experimental Physiology
2014 - Present Journal of Cardiovascular Pharmacology
2014 - Present Endocrine
2014 - Present Yonsei Medical Journal
2014 - Present Journal of the American Heart Association (JAHA)
2014 - Present Advances in Pharmacology
2014 - Present BMC Medical Genetics
2014 - Present Microcirculation
2014 - Present Diabetes
2015 - Present Neuropsychopharmacology
2015 - Present Journal of Thermal Biology
2016 - Present Scientific Reports
2016 - Present American Journal of Physiology: Endocrinology & Metabolism
2018 - Present Nutrition and Diabetes
2024 - Present Journal of the American Association of Laboratory Animal Science (JAALAS)

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
2000 - 2001 President, Alpha Eta Chapter, Beta Beta Beta Biological Honor Society, Hope College
2008 - 2010 Member, Trainee Advocacy Committee, American Heart Association / Council on Hypertension
2010 - 2013 Chair, Trainee Advocacy Committee, American Heart Association / Council on Hypertension
2011 - 2012 Member, Early Career Task Force, American Heart Association / Council Operations Committee
2013 - 2023 Member, Nominating Committee, American Heart Association / Council on Hypertension
2013 Member, Hypertension Summer School Planning Committee, American Heart Association / Council on Hypertension
2014 - 2017 Vice-Chair, Research Committee, American Heart Association / Midwest Affiliate
2015 - 2016 Coordinator, Data Diuresis Session, American Physiological Society / Water & Electrolyte Homeostasis Section
11/2018 Ad hoc reviewer, F10A-R (Fellowships) study section, NIH CSR
2018 - 2023 Member, Membership & Communications Committee, American Heart Association / Council on Hypertension
02/2019 Ad hoc reviewer, Hypertension & Microcirculation (HM) study section, NIH CSR
04/2019 Ad hoc reviewer, Vascular & Hematology AREA (R15) study section, NIH CSR
2019 - 2023 Member, HTN Fall Specialty Conference Planning Committee, American Heart Association / Council on Hypertension
02/2020 Ad hoc reviewer, P01 Special Emphasis Panel, NIH CSR
06/2020 Ad hoc reviewer, Hypertension & Microcirculation (HM) study section, NIH CSR
2020 - 06/30/2022 Member, Council Operations Committee / Mid-Career Subcommittee, American Heart Association
2020 - 2022 Member, Water & Electrolyte Homeostasis Section Awards Committee, American Physiological Society
02/2021 Ad hoc reviewer, P01 Special Emphasis Panel, NIH CSR
06/2021 Ad hoc reviewer, Translational Research Institute for Space Health (TRISH) Biomedical Research Advances for Space Health (BRASH2101), National Aeronautics and Space Administration (NASA)
10/2021 Ad hoc reviewer, P01 Special Emphasis Panel, NIH CSR
01/2022 Ad hoc reviewer, P01 Special Emphasis Panel, NIH CSR
06/2022 Ad hoc reviewer, POMD study section, NIH CSR
11/2022 Ad hoc reviewer, Fellowship Clinical 1 (pre- and post-doctoral fellowship), American Heart Association
11/2023 Ad Hoc Reviewer, Fellowship Clinical 2 (pre- and post-doctoral fellowship), American Heart Association

INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
2023 Ad hoc, Interdisciplinary & International Projects [Spark] review panel, Swiss National Science Foundation (SNSF)

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
MCW CTSI Obesity Ensemble
Source:
MCW Clinical & Translational Science Institute / National Institutes of Health (UL1TR001436)
Role & Effort:
Ensemble Member
PI:
Shaker
Dates:
2020 - Present
Direct Funds:
$50,000 (initial)
  
Title:
MCW CTSI "Preconception To Toddler Study (PTTS)" Ensemble
Source:
MCW Clinical & Translational Science Institute / National Institutes of Health (UL1TR001436)
Role & Effort:
Ensemble Member
PI:
Shaker
Dates:
2021 - Present
Direct Funds:
$35,000 (initial)
  
Title:
R01 DK133121 Impact of Early Life Sodium Intake on Growth and Metabolism - Role of Hypothalamic Mechanisms
Source:
NIH / NIDDK
Role & Effort:
Multiple-PI
PI:
Grobe + Segar (MPI)
Dates:
08/12/2022 - 05/31/2026
Direct Funds:
$1,248,788 (Total award = $1,948,108)
  
Title:
R01 HL134850 Angiotensin receptor G protein signal switching in AgRP neurons in cardiometabolic control
Source:
NIH / NHLBI
Role & Effort:
PI
PI:
Grobe
Dates:
03/15/2023 - 02/28/2027
Direct Funds:
$1,637,012 (This award represents a competitive renewal (years 7-10) of R01 HL134850. Total award = $2,553,740. )
  
Prior
Peer Review
Title:
NSF REU Fellowship, Hope College
Source:
National Science Foundation
Role & Effort:
Principal Investigator
PI:
Grobe
Dates:
05/1998 - 08/1998
Direct Funds:
$2,500
  
Title:
Undergraduate Summer Research Fellowship
Source:
American Heart Association Midwest Affiliate
Role & Effort:
Principal Investigator
PI:
Grobe
Dates:
05/1999 - 08/1999
Direct Funds:
$2,500
  
Title:
NSF REU Fellowship, University of Florida
Source:
National Science Foundation
Role & Effort:
Principal Investigator
PI:
Grobe
Dates:
05/2000 - 08/2000
Direct Funds:
$2,500
  
Title:
Alumni Fellowship
Source:
University of Florida College of Pharmacy
Role & Effort:
Principal Investigator
PI:
Grobe
Dates:
08/2001 - 06/2003
Direct Funds:
$40,000 (total for all years)
  
Title:
Pre-doctoral Research Fellowship 0315130B "Attenuation of Experimental Hypertension by Lentiviral Delivery of Tetracycline-Regulated Angiotensinogen Antisense"
Source:
American Heart Association, Florida/Puerto Rico Affiliate
Role & Effort:
Principal Investigator
PI:
Grobe
Dates:
07/2003 - 06/2005
Direct Funds:
$38,000 (total for all years)
  
Title:
Implications for Blood Pressure Control in Pregnancy"
Source:
American Heart Association, Florida/Puerto Rico Affiliate
Role & Effort:
Principal Investigator
PI:
Grobe
Dates:
07/2005 - 06/2006
Direct Funds:
$19,000
  
Title:
T32 HL007121 Cardiovascular Interdisciplinary Research Fellowship
Source:
NIH / NHLBI
Role & Effort:
Principal Investigator
PI:
Grobe
Dates:
08/2006 - 08/2007
Direct Funds:
$35,000
  
Title:
Post-doctoral Fellowship in Physiological Genomics
Source:
American Physiology Society
Role & Effort:
Principal Investigator
PI:
Grobe
Dates:
08/2007 - 08/2009
Direct Funds:
$79,000 (total for all years)
  
Title:
T32 DK007690 Training in Kidney Disease, Hypertension, Cell Biology
Source:
NIH / NIDDK
Role & Effort:
Principal Investigator
PI:
Grobe
Dates:
07/2009 - 06/2010
Direct Funds:
$42,000
  
Title:
K99 HL098276 Metabolism, Fluid Balance, and Hypertension
Source:
NIH / NHLBI
Role & Effort:
Principal Investigator
PI:
Grobe
Dates:
06/2010 - 05/2012
Direct Funds:
$197,815 (total for all years)
  
Title:
R00 HL098276 Metabolism, Fluid Balance, and Hypertension
Source:
NIH / NHLBI
Role & Effort:
Principal Investigator
PI:
Grobe
Dates:
06/2012 - 05/2015
Direct Funds:
$546,443 (total for all years)
  
Title:
All in the head? Investigating the Molecular Role of Vasopressin in Preeeclampsia
Source:
University of Iowa Carver Collaborative Pilot Grant
Role & Effort:
Co-Principal Investigator (with MK Santillan)
PI:
Grobe + Santillan
Dates:
03/2013 - 02/2014
Direct Funds:
$50,000
  
Title:
P01 HL084207 Genetic and Signaling Mechanisms in the Central Regulation of Blood Pressure
Source:
NIH / NHLBI
Role & Effort:
Co-I
PI:
Sigmund
Dates:
04/2013 - 03/2018
Direct Funds:
$220,000 (total for all years)
  
Title:
a common mechanism for the development of obesity and inflammatory pain
Source:
University of Iowa Major Project Pilot Grant
Role & Effort:
Co-Principal Investigator (with DP Mohapatra)
PI:
Grobe + Mohapatra
Dates:
01/2014 - 01/2015
Direct Funds:
$50,000
  
Title:
1-14-BS-079 Required Interaction of Leptin with Angiotensin in Metabolic Control
Source:
American Diabetes Association
Role & Effort:
Principal Investigator
PI:
Grobe
Dates:
01/2014 - 12/2016
Direct Funds:
$270,000 (total for all years)
  
Title:
14IRG18710013 Vasopressin as an early-pregnancy initiator of preeclampsia
Source:
American Heart Association
Role & Effort:
Principal Investigator
PI:
Grobe
Dates:
01/2014 - 12/2015
Direct Funds:
$150,000 (total for all years)
  
Title:
An Untapped Obesity Target?
Source:
Fraternal Order of Eagles' Diabetes Research Center Pilot Grant
Role & Effort:
Principal Investigator
PI:
Grobe
Dates:
09/2014 - 08/2016
Direct Funds:
$100,000 (total for all years)
  
Title:
15SFRN23730000 Molecular Mechanisms of Vasopressin-Induced Preeclampsia
Source:
American Heart Association
Role & Effort:
Principal Investigator, Basic Science Project
PI:
PI: Grobe / PD: Sigmund
Dates:
04/2015 - 03/2019
Direct Funds:
$960,000 (total for all years)
  
Title:
Placental Gαq Signaling in Preeclampsia
Source:
UIHC Center for Hypertension Research
Role & Effort:
Co-Principal Investigator (with KN Gibson-Corley)
PI:
Grobe + Gibson-Corley
Dates:
07/2016 - 06/2017
Direct Funds:
$40,000
  
Title:
R01 HL134850 Interaction between leptin and angiotensin in the pathogenesis of obesity-hypertension
Source:
NIH / NHLBI
Role & Effort:
Principal Investigator
PI:
Grobe
Dates:
01/2017 - 12/2021
Direct Funds:
$1,250,000
  
Title:
Pilot Project 1
Source:
Carmentix / Esco Ventures
Role & Effort:
Co-Principal Investigator
PI:
Grobe + Santillan
Dates:
07/2017 - 12/2017
Direct Funds:
$9,000
  
Title:
18EIA33890055 Hypothalamic mechanisms of cardiometabolic and obstetric disease
Source:
American Heart Association
Role & Effort:
Principal Investigator
PI:
Grobe
Dates:
01/2018 - 12/2022
Direct Funds:
$400,000 (total for all years)
  
Title:
Pilot Project 2
Source:
Carmentix / Esco Ventures
Role & Effort:
Co-Principal Investigator
PI:
Grobe + Santillan
Dates:
01/2018 - 06/2018
Direct Funds:
$1,500
  
Title:
Are Principal Cells the 'Principal Problem' for Preeclampsia?
Source:
Carver Trust Medical Research Initiative Grant
Role & Effort:
Principal Investigator
PI:
Grobe
Dates:
07/2018 - 06/2019
Direct Funds:
$30,000
  
Title:
P01 HL084207 Genetic and Signaling Mechanisms in the Central Regulation of Blood Pressure
Source:
NIH / NHLBI
Role & Effort:
Principal Investigator, Project 4
PI:
PI: Grobe / PD: CD Sigmund
Dates:
08/2018 - 07/2023
Direct Funds:
$1,446,915 (total for all years)
  
Title:
Relationship between resting metabolic rate, body weight, and gut microbiome in African Americans
Source:
Advancing a Healthier Wisconsin Research & Education Program
Role & Effort:
Co-I
PI:
Kidambi
Dates:
2020
Direct Funds:
$250,000
  
Title:
Long-term Maternal Cardiovascular Risk Associated with Preeclampsia
Source:
MCW Cardiovascular Center FY24 Women's Cardiovascular Health Award
Role & Effort:
Co-I
PI:
Weiler
Dates:
07/2023 - 06/2024
Direct Funds:
$50,000
  

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
International
Gordon Research Conference: Angiotensin, Lucca (Barga), Italy, 2014
High Blood Pressure Research Council of Australia / Australian Atherosclerosis Society / the Australian Vascular Biology, Hobart (Tazmania), Australia, 2016
Angiotensin action within the arcuate nucleus of the hypothalamus in cardiometabolic control, Vasoactive Peptides, Brazil, 10/16/2021
 
National
Experimental Biology, San Diego, CA, 2008
Gordon Research Conference: Angiotensin, Ventura, CA, 2008
American Heart Association Council for High Blood Pressure Research, Tucson, AZ, 2008
Univ. of Florida, Dept of Physiology & Functional Genomics, Gainesville, FL, 2010
American Heart Association Council for High Blood Pressure Research, Orlando, FL, 2011
Pennsylvania State University, Dept of Cellular & Molecular Phys, Hershey, PA, 2011
University of Kentucky, Graduate Center for Nutritional Sciences, Lexington, KY, 2011
Hope College Department of Biology, Holland, MI, 2011
American Heart Association Council for High Blood Pressure Research, Washington, DC, 2012
Gordon Research Seminar: Angiotensin, Orlando, FL, 2012
American Physiological Society NCAR section conference: Autonomic Regulation of Cardiovascular Function in Health and Disease, Omaha, NE, 2012
Experimental Biology, Boston, MA, 2013
Goldblatt Award Competition, American Heart Association Council for High Blood Pressure Research, New Orleans, LA, 2013
American Heart Association Council for High Blood Pressure Research, Hypertension Summer School 2013, Columbia, SC, 2013
Univ of North Texas Health Sci Ctr, Dept Integrative Physiol & Anatomy, Fort Worth, TX, 2014
Young Scholar Award Lecture, American Society of Hypertension Annual Meeting, New York, NY, 2014
International Academy of Cardiovascular Sciences, Omaha, NE, 2015
University of Wyoming, Laramie, WY, 2015
Goldblatt Award Lecture, American Heart Association Council for High Blood Pressure Research, Washington, DC, 2015
Water & Electrolyte Homeostasis Section New Investigator Award, American Physiological Society, Boston, MA, 2015
Medical College of Wisconsin, Department of Physiology, Milwaukee, WI, 2016
FASEB Summer Research Conference: Neural Mechanisms in Cardiovascular Regulation: Novel Research and Disease Treatment Strategies, Saxtons River, VT, 2016
Medical College of Wisconsin, Department of Physiology, Milwaukee, WI, 2018
American Heart Association Council on Hypertension, New Orleans, LA, 2019
Angiotensin within the hypothalamic arcuate nucleus in cardiometabolic control during obesity, Neural & Behavioral Sciences, Penn State College of Medicine, 2021
Cardiometabolic adaptation during obesity: Role of the local renin-angiotensin system within the arcuate nucleus of the hypothalamus, Center for Integrative Cardiovascular and Metabolic Disease, University of Florida, 2021
Combining Direct + Indirect Calorimetry to Improve Quantification of Energy Expenditure, Division of Endocrinology Grand Rounds, Beth Israel Deaconess Medical Center / Harvard Medical School, 2022
Resting Metabolism: Control by the Brain, and Contributions of the Gut, Department of Physiology and Pharmacology Molecular Medicine (MOME) Seminar Series, University of Toledo, 2022
Angiotensin in the Arcuate: Unlocking Neural Mechanisms Integrating Cardiometabolic Control in Health and Disease, Pharmacology Seminar Program, Tulane University, 2022
Angiotensin in the Arcuate: Unlocking Neural Mechanisms Integrating Cardiometabolic Control in Health & Disease, American Heart Association Council on Hypertension 2022 Scientific Sessions, San Diego, CA, 2022
Cardiometabolic Control by Angiotensin in the Arcuate Nucleus of the Hypothalamus, LSUHSC Cardiovascular Center for Excellence, Louisiana State University Health Science Center, 2024
 
Regional
Fraternal Order of Eagles' Missouri, Iowa, Nebraska, Kansas and North & South Dakotas (MINK) section annual conference, Omaha, NE, 2016
American Diabetes Association Iowa / Nebraska / South Dakota section Donor Dinner, Riverside, IA, 2016
Cardiometabolic adaptation during obesity: Role of the local renin-angiotensin system within the arcuate nucleus of the hypothalamus, Departments of Biomedical Sciences & Biological Sciences, Marquette University, 2021
 
Local
Internal Medicine Research Day, University of Iowa, 2008
Department of Pharmacology Seminar, University of Iowa, 2011
Division of Nephrology Seminar, University of Iowa, 2011
Molecular & Cellular Biology Interdisciplinary Program Seminar, University of Iowa, 2012
Department of Biochemistry Seminar, University of Iowa, 2012
Department of Pharmacology Seminar, University of Iowa, 2013
Obesity Initiative, University of Iowa, 2013
University of Iowa MSTP (MD/PhD program) summer seminar series, University of Iowa, 2013
Department of Pharmacology Seminar, University of Iowa, 2014
40th Anniversary of the François M. Abboud Cardiovascular Research Center, University of Iowa, 2014
Biosciences Program Summer Undergraduate Seminar Series, University of Iowa, 2014
Obesity Research & Education Initiative, University of Iowa, 2015
IT Community Meeting, University of Iowa, 2015
Department of Pharmacology Seminar, University of Iowa, 2015
Biosciences Program Summer Undergraduate Seminar Series, University of Iowa, 2016
Toxicology/EHSRC/Superfund Seminar, University of Iowa, 2017
Carl Gisolfi Memorial Lecture, University of Iowa, 2017
Obesity Research & Education Initiative, University of Iowa, 2018
Vasopressin, copeptin, and GPCR signaling in preeclampsia, Preeclampsia Working Group, Medical College of Wisconsin, 2019
Single-nuclear RNAseq in the arcuate nucleus of the hypothalamus deconvolutes the cellular and molecular basis of selective leptin resistance and obesity-associated hypertension, Department of Physiology, Medical College of Wisconsin, 2019
Vasopressin/Copeptin and Preeclampsia, Cardiovascular Center Annual Retreat, Medical College of Wisconsin, 2019
Cardiometabolic adaptation during obesity: Role of the local renin-angiotensin system within the arcuate nucleus of the hypothalamus, City-Wide Obesity and Metabolic Disease Grand Rounds, Milwaukee, WI, 2020
Regulator of G-protein Signaling-2 in Preeclampsia, WHRP Seminar Series, Medical College of Wisconsin, 2020
Cardiometabolic adaptation during obesity: Role of the local renin-angiotensin system within the arcuate nucleus of the hypothalamus, Department of Physiology "Friends of MCW Physiology" Seminar Series, Milwaukee, WI, 2021
Metabolic adaptation after obesity: Why can’t we lose weight and keep it off?, MSTP program seminar series, 2023
Angiotensin AT1R in Agouti-related peptide (AgRP) neurons in the control of resting metabolism, MCW CVC ATVB group seminar series, 2023
 

COMMITTEE SERVICE:
Medical College of Wisconsin
2019 - Present Member, MSTP Admissions Committee, Medical College of Wisconsin
2019 - Present Member, Institutional Animal Care & Use Committee (Vice-Chair, 2022-present), Medical College of Wisconsin
2023 - Present Member, Search Committee; Director of the Neuroscience Research Center, Medical College of Wisconsin
 

MCW TEACHING ACTIVITIES:
Medical Student Education
2020 - 2022 Lecturer, Medical Physiology (The Microcirculation and the Lymphatic System: Capillary Fluid Exchange, Interstitial Fluid, and Lymph Flow)
2021 - 2022 Lecturer, Medical Physiology (Overview of Circulation and Hemodynamics, part 2)
2021 - 2022 Lecturer, Medical Physiology (Overview of Circulation and Hemodynamics, part 1)
 
Graduate Student Education
2020 - 2022 Course Director and Primary Instructor - PHYS 08220: Biostatistics for Health Sciences
2022 - Present Section Lead and Lecturer - PHYS 08270: Current Concepts in Cardiovascular Biology (Hypertension Section)
2023 - Present Co-Course Director and Instructor - INDP 16245: Statistics for Basic Sciences
 

EXTRAMURAL TEACHING:
Graduate Student Education
2011 - 2013 University of Iowa, Facilitator, PCOL:7270 (650:270) - "Principles of Scholarly Integrity"
2011 - 2017 University of Iowa, Lecturer, PCOL:5137 (071:137) - "Neurotransmitters"
2012 University of Iowa, Primary Instructor, BISC:5265 (156:265) - "Biosciences Critical Thinking & Communication"
2012 University of Iowa, Discussion Leader, "Teaching Your Research"
2015 University of Iowa, Course Director, PCOL:6030 - "Topics in Pharmacology"
2015 University of Iowa, Lecturer, PCOL:8240 - "Basic Pharmacology for Dental Students"
2015 - 2018 University of Iowa, Lecturer, TBM:5001 - "Introduction to Translational Biomedicine"
2015 - 2018 University of Iowa, Course Founder & Director, and Primary Instructor, PCOL:5204 - "Basic Biostatistics & Experimental Design"
2016 - 2018 University of Iowa, Lecturer, PATH:5260 (069:260) - "Translational Histopathology"
2019 University of Iowa, Lecturer, MMED:6260 - "Methods for Molecular and Translational Medicine"
 
Continuing Medical Education
2012 University of Iowa, Obesity 2012: Building a Dream Team
2014 University of Iowa, Maternal-Fetal Medicine Fellows Conference Lecture "Altered pharmacology in pregnancy"
2015 University of Iowa, Maternal-Fetal Medicine Fellows Conference Lecture "Fluid and electrolyte balance in pregnancy"
 

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
High School Students
2020 Olivia Eckes, Medical College of Wisconsin, SUPREMES program
 
Undergraduate Students
2022 Daeleon Brown-Williams, Medical College of Wisconsin, 2022 SPUR fellowship
2023 - 2024 Jhonatan Pasos-Cortes, Medical College of Wisconsin, One-year externship (visiting student from Colombia); 2024 AHA Hypertension Scientific Sessions Award for Support of Underrepresented Minorities
2023 Alyssa M. Madison, Medical College of Wisconsin, 2023 SPUR fellowship
2024 Margaret (Meg) Dorrington, Medical College of Wisconsin, Summer 2024 SPUR fellowship; 2024-2025 academic year PURE program
2024 Kush Nandani, Medical College of Wisconsin, 2024 ASPIRE fellowship
 
Medical Students
11/2021 - Present Micah P. Wildes, Pathway Advisor, Medical College of Wisconsin, 2022 MSSRP fellowship (T35 HL072483)
2022 - 2024 Samuel Lawton, Medical College of Wisconsin, 2023 MSSRP fellowship (T35 HL072483); admitted as an "internal candidate" to MCW MSTP program, May 2024
 
Graduate Students
PhD Students Advised
2019 - 2023 McKenzie L. Ritter, (Physiology), Medical College of Wisconsin, 2021 MCW Physiology T32 Fellowship (HL007852); 2021-2023 AHA predoctoral fellowship (903246)
2019 - 2023 Megan (Vande Hei) Opichka, (Physiology), Medical College of Wisconsin, 2021 MCW Physiology T32 Fellowship (HL007852); 2021-2023 American Heart Association Predoctoral Fellowship (826132); 2021 MCW CVC Retreat 2nd place presentation award; 2023 Outstanding Dissertation Award
2021 - Present Alisha A. Ziegler, (Physiology), Medical College of Wisconsin, Thesis co-mentor with Jeffrey L. Segar, MD; 2022 MCW Physiology T32 Fellowship (HL007852)
2024 - Present Samuel B.R. Lawton, Medical College of Wisconsin, Admitted as 'internal candidate' to MCW MSTP in May 2024; AHA Hypertension 2024 New Investigator Award from HTN and KCVD councils
PhD Committees
2020 - Present Matthew Hadiono (Kirby lab, Microbiology), Medical College of Wisconsin
2021 - Present Alexis Kazen (Kirby lab, Microbiology), Medical College of Wisconsin
2021 - Present Fatima Aboulalazm (Kirby lab, Microbiology), Medical College of Wisconsin
2021 - 2023 Santiago Alvarez (O'Meara lab, Physiology), Medical College of Wisconsin
2022 - Present Lauren Yunker (Kriegel lab, Physiology), Medical College of Wisconsin
2022 - 2024 Natalia M. Mathieu (Sigmund lab, Physiology), Medical College of Wisconsin
2023 - Present Autumn Hamilton (Sigmund lab, Physiology), Medical College of Wisconsin
2023 - Present Tyler Laib (Kirby lab, Microbiology), Medical College of Wisconsin
Students Advised
2023 Jared R. Burks, (Biomedical Engineering), Medical College of Wisconsin
 
Postdoctoral Students
02/01/2019 - 05/03/2021 Vanessa A. De Oliveira, PhD, Medical College of Wisconsin, (Now faculty at UNIFENAS Universidade, Divinopolis, Brazil)
03/01/2019 - 06/30/2021 Chetan N. Patil, PhD, Medical College of Wisconsin, (Now a Research Scientist at MCW / Pediatric Nephrology)
08/01/2019 - 10/01/2023 Kirthikaa Balapattabi, PhD, Medical College of Wisconsin, 2019 APS NCARnation finalist; 2021 NIH Outstanding Scholars in Neuroscience Award (OSNAP); 2021-2022 American Physiological Society Postdoctoral Fellowship; 2021 NCW Office of Postdoctoral Education Postdoc Professional Developmental Award; 2021-2023 AHA Postdoctoral Fellowship (898067)
 
Clinical/Research Fellows
07/2022 - 06/2024 Colin M.L. Burnett, MD, MS, (Cardiology / Electrophysiology), Medical College of Wisconsin
07/2023 - 06/2025 Benjamin Araya, DO, (Pediatrics / Neonatology), Medical College of Wisconsin
 
Faculty
2020 - Present Lisa L. Morselli, MD, PhD, (Internal Medicine / Endocrinology), Medical College of Wisconsin
07/2024 - Present Colin M.L. Burnett, MD, MS, (Cardiology / Electrophysiology), Medical College of Wisconsin
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
High School Students
2014 Whitney Li, University of Iowa, 2014 Secondary Student Training Program (SSTP) fellowship
2014 - 2015 Jonathan Ni, University of Iowa
2015 Emily G. Suen, University of Iowa, 2015 Secondary Student Training Program (SSTP) fellowship
2015 Sriram Sugumaran, University of Iowa
2016 Mengda (Amanda) Liu, University of Iowa, 2016 Secondary Student Training Program (SSTP) fellowship
2017 Lily Jiaqi Cao, University of Iowa, 2017 Secondary Student Training Program (SSTP) fellowship
2017 Andrew Usachev, University of Iowa
 
Undergraduate Students
2010 - 2012 Beth A. Buehrer, University of Iowa, 2010-2011 Iowa Center for Research by Undergraduates (ICRU) academic year fellowship; 2011 Research at the Capitol Day 2011 (UI representative); 2011 AHA summer research fellowship; 2011-2012 Iowa Center for Research by Undergraduates (ICRU) academic year fellowship
2011 - 2014 Benjamin J. Weidemann, University of Iowa, 2012 AHA summer fellowship; 2012-2013 Iowa Center for Research by Undergraduates (ICRU) academic year fellowship; 2013 Iowa Center for Research by Undergraduates (ICRU) travel award; 2013 American Physiological Society Undergraduate Research Excellence Fellowship award (UGREF); 2013 University of Iowa "SUMR" pre-MD/PhD program summer research fellowship; 2013 University of Iowa Department of Chemistry Undergraduate Award; 2013-2014 Iowa Center for Research by Undergraduates (ICRU) academic year fellowship; 2014 Research at the Capitol Day UI representative; 2014 American Physiological Society Undergraduate David S. Bruce award; 2014 University of Iowa Department of Pharmacology Amanda Hope Skolnick Memorial Award; 2014 University of Iowa Department of Chemistry Merck Index Award
2012 - 2014 Susan Voong, University of Iowa, American Physiological Society Undergraduate Summer Research Fellowship award (UGSRF)
2012 Aaron F. Sigmund, University of Iowa
2014 - 2016 Kevin V. Tobin, University of Iowa
2014 - 2017 Danny W. Linggonegoro, University of Iowa, 2015 AHA summer fellowship; 2015-2016 Iowa Center for Research by Undergraduate academic year fellowship; 2016 American Diabetes Association Minority Undergraduate Internship #1-16-MUI-06; 2016 Research at the Capitol Day representative; 2016 University of Iowa Center for Research by Undergraduate Excellence in Undergraduate Research Award; 2016 American Physiological Society Undergraduate Research Excellence Fellowship award (UGREF)
2014 Fabiola I. Morales, University of Iowa, 2014 University of Iowa Summer Research Opportunities Program (SROP) fellowship
2014 - 2016 Erica R. Cole, University of Iowa, 2015 Iowa Center for Research by Undergraduates (ICRU) travel award; 2015-2016 Iowa Center for Research by Undergraduates (ICRU) academic year fellowship
2016 Marquis R. Smith, University of Iowa, 2016 Summer Research Opportunities Program (SROP) fellowship
2016 - 2019 Shao Yang Zhang, University of Iowa, 2017 American Physiological Society Undergraduate Summer Research Fellowship (UGSRF); 2017-2018 University of Iowa Academic Year Iowa Center for Research by Undergraduates (ICRU) Research Fellowship; 2018 Experimental Biology Barbara A. Horowitz & John M. Horowitz Undergraduate Research Award; 2018 American Physiological Society Undergraduate Research Excellence Fellowship (UGREF); 2018-2019 University of Iowa Academic Year Iowa Center for Research by Undergraduates (ICRU) Research Fellowship; 2019 APS Barbara A. and John M. Horwitz Undergraduate Abstract Award at EB 2019
2016 Alyssa T. Ray, University of Iowa, 2016 University of Iowa Center for Research by Undergraduate (ICRU) summer fellowship
2016 - 2018 Jairui Xue, University of Iowa
2016 Phillip Witcher, University of Iowa, 2016 University of Iowa "SUMR" pre-MD/PhD program summer fellowship
2017 Casee Meincke, University of Iowa, 2017 University of Iowa Center for Research by Undergraduates (ICRU) summer fellowship
2018 Kevin Chen, University of Iowa, 2018 American Physiological Society Summer Undergraduate Research Fellowship (UGSRF)
2018 - 2019 Caitlyn E. Owens, University of Iowa
 
Medical Students
2010 Scott G. Westphal, University of Iowa
2011 Rick B. Siel, Jr., University of Iowa, 2011 Medical Student Research Program summer fellowship; 2011 "Edward Heath Award" for outstanding Medical Student research
2012 - 2016 Matthew D. Folchert, University of Iowa, Research Distinction Track (RDT); 2012 Medical Student Research Program summer fellowship
2013 - 2016 James Y. Min, University of Iowa, Research Distinction Track (RDT); 2013 Medical Student Research Program 2013 summer fellowship
2015 - 2019 Ruth A. Riedl, University of Iowa, Medical Student Research Distinction Track (RDT); 2015 University of Iowa "SUMR" pre-MD/PhD program summer fellowship; 2016 Medical Student Research Program summer fellowship; 2016 Outstanding Presentation in Pharmacological Research Award; 2017 Medical Student Research Program summer fellowship; 2017 Outstanding Presentation in Pharmacological Research Award; Research Distinction Track
2017 - 2019 Kendra L. Frey, University of Iowa, 2017 Medical Student Research Program summer fellowship; Research Distinction Track
2018 - 2019 John (Jackson) W. Walsh, University of Iowa, 2018 Medical Student Research Program summer fellowship; Research Distinction Track
 
Graduate Students
PhD Students Advised
2012 - 2015 Nicole K. Littlejohn, Tissue-specific Roles for the Renin-Angiotensin System in Cardiovascular and Metabolic Regulation, University of Iowa, Pharmacology, 2013 AHA Council on Hypertension New Investigator Travel Award; 2014-2015 AHA Predoctoral Fellowship #14PRE18330015; 2016 Gordon Research Conference on Angiotensin invited speaker
2013 - 2019 Jeremy A. Sandgren, Vasopressin in Preeclampsia, University of Iowa, Pharmacology / Medical Scientist Training Program, Medical Scientist Training Program (MSTP) MD/PhD; 2014-2015 Pharmacological Sciences Predoctoral Fellowship T32 GM067795; 2015 Experimental Biology WEH Data Diuresis invited speaker; 2016-2018 AHA Predoctoral Fellowship #16PRE30980043; 2016-2017 University of Iowa Department of Pharmacology Ranbir K. Bhatnagar Scholar Award; 2017 Experimental Biology Water & Electrolyte Homeostasis Section Graduate Student Oral Competition (1st Place)
2013 - 2016 Kristin E. Claflin (Yin), The Brain Renin-Angiotensin System in Metabolic and Cardiovascular Regulation, University of Iowa, Pharmacology, 2014-2016 AHA Predoctoral Fellowship #14PRE20380401; 2016 Gordon Research Conference on Angiotensin invited speaker
2015 - 2018 Katherine J. Perschbacher, Reduced Placental Expression of Regulator of G Protein Signaling-2 (RGS2) in Preeclampsia: Association, Consequence, and Cause, University of Iowa, Molecular & Cellular Biology, Molecular & Cellular Biology (2015-2018). 2017 University of Iowa Graduate College Post-comprehensive Research Fellowship; 2017 Molecular & Cellular Biology Graduate Program travel award; 2017-2019 AHA Predoctoral Fellowship #17PRE33660633; 2017-2018 University of Iowa Department of Pharmacology Ranbir K. Bhatnagar Scholar Award; 2017 Finalist / Honorable Mention, University of Iowa Graduate College "3 minute Thesis" Oral Presentation Competition; 2018 Experimental Biology Water & Electrolyte Homeostasis Section Data Diuresis invited speaker
2016 - 2019 Sarah A. Sapouckey, The Renin-Angiotensin System in Metabolism and Development, University of Iowa, Molecular & Cellular Biology, 2017 Molecular & Cellular Biology Graduate Program travel award; 2018 Gordon Research Conference on Angiotensin invited speaker; 2018-2020 AHA Predoctoral Fellowship #18PRE33960377
PhD Committees
2012 Aaron Mickle, University of Iowa
2012 Kyle Flippo, University of Iowa
2013 Jacqueline Reilly, University of Iowa
2014 Balyssa Bell, University of Iowa
2015 Rachel Minerath, University of Iowa
2015 Magdalene Ameka, University of Iowa
2016 Yujia (Jennie) Liu, University of Iowa
2016 Lucas Bon Durant, University of Iowa
2016 Samantha N. Atkinson, University of Iowa
2016 Maria F. Noterman, University of Iowa
2016 Alexander (Sasha) Tereshchenko, University of Iowa
2016 Dylan Todd, University of Iowa
2016 Rebecca K. Autenried, University of Iowa
2017 Gail I. Harmata, University of Iowa
2017 Serena (Banu) Gumusoglu, University of Iowa
2017 Frida A. Teran, University of Iowa
2018 Rachel Schroeder, University of Iowa
2018 Thomas Pak, University of Iowa
2018 Grant Walters, University of Iowa
2019 Mackenzie M. Spicer, University of Iowa
2021 - Present Aaron A. Jones (Arble lab, Biological Sciences), Marquette University
MS Committees
2014 Ko-Ting Lu, University of Iowa
2015 Hannah Van Beek, University of Iowa
 
Postdoctoral Students
01/01/2017 - 06/30/2019 Guorui Deng, PhD, University of Iowa, 2017-2019 AHA Strategically Focused Research Network H3 Fellow; 2018 Gordon Research Conference on Angiotensin outstanding poster presentation award; 2018 FOEDRC Research Day outstanding poster presentation award; April 2019 - Mar 2021 American Heart Association Postdoctoral Fellowship (19POST34380239); 2019 Trainee Research Excellence Award sponsored by Data Sciences International (DSI) from the American Physiological Society Physiological ‘Omics research group (Now postdoc at University of Iowa)
 
Clinical/Research Fellows
2012 - 2019 Colin M.L. Burnett, MD, MS, University of Iowa, 2012 Medical Student Research Program summer fellowship; 2012 Outstanding Presentation in Pharmacological Research Award; 2013 Medical Student Research Program summer fellowship; 2013 Outstanding Presentation in Pharmacological Research Award
07/01/2017 - 06/30/2019 Lisa L. Morselli, MD, PhD, University of Iowa, Endocrinology Fellow. 2017-2019 University of Iowa Multidisciplinary Lung Research Career Development Program Fellowship # T32 HL007638
 
Faculty
2022 - Present Sabrina Scroggins, PhD, External K01/KL2 advisory committee member, University of Minnesota, Duluth
 

COMMUNITY SERVICE ACTIVITIES:
1997 - 1998 Microbiology teaching laboratory preparation, Hope College Department of Biology, Holland, MI
1998 - 2002 Webmaster, Hope College Department of Biology, Holland, MI
2001 - 2002 Department Representative, University of Florida Graduate Student Council, Gainesville, FL
2001 - 2004 Website design team, University of Florida Department of Pharmacodynamics, Gainesville, FL
2005 - 2006 Congregational Council (Secretary, 2006), University Lutheran Church, Gainesville, FL
2015 University of Iowa / Fraternal Order of Eagles' Diabetes Research Center representative to, National FOE Convention, Milwaukee, WI
2015 Community science outreach, Walcott, IA Lion's Club
2016 Represented Diabetes Research Center, and presented ongoing research to, Missouri / Iowa / Nebraska / Kansas / Dakotas chapter of the Fraternal Order of Eagles' (FOE MINK), Omaha, NE
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Burnatowska-Hledin M, Zeneberg A, roulo A, Grobe JL, Zhao P, Lelkes PI, Clare P, Barney C. Expression of VACM-1 protein in cultured rat adrenal endothelial cells is linked to the cell cycle, Endothelium. 2001;8(1):49-63. PMID:11409851.
2. Barney CC, Kurylo DM, Grobe JL. Thermal dehydration-induced thirst in lithium-treated rats, Pharmacol Biochem Behav. 2003 May;75(2):341-347. PMID:12873625.
3. Grobe JL, Katovich M, Rowland N. Role of angiotensin II in the subfornical organ in the pharmacological actions of ethanol, Alcohol and Alcoholism. 2004 September;39(5):410-417. PMID:15289207.
4. Huentelman MJ, Grobe JL, Vazquez J, Stewart JM, Mecca AP, Katovich MJ, Ferrario CM, Raizada MK. Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats, Exp Physiol. 2005 September;90(5):783-790. PMID:16049057.
5. Grobe JL, Katovich MJ. Alterations in aortic vascular reactivity to angiotensin 1-7 in 17-beta-estradiol-treated female SD rats, Regul Pept. 2006 January 15;133(1-3):62-67. PMID:16219374.
6. Grobe JL, Mecca AP, Mao H, Katovich MJ. Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension, Am J Physiol Heart Circ Physiol. 2006 June;290(6):H2417-H2423. PMID:16415071.
7. Li H, Gao Y, Grobe JL, Raizada MK, Katovich MJ, Sumners C. Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor, Am J Physiol Heart Circ Physiol. 2007 February;2992(2):H727-H735. PMID:17085538.
8. Grobe JL, Mecca AP, Lingis M, Shenoy V, Bolton TA, Machado JM, Speth RC, Raizada MK, Katovich MJ. Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7), Am J Physiol Heart Circ Physiol. 2007 February;292(2):H736-H742. PMID:17098828.
9. Grobe JL, Der Sarkissian S, Stewart JM, Meszaros JG, Raizada MK, Katovich MJ. ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts, Clin Sci (Lond). 2007 October;113(8):357-364. PMID:17600530.
10. Der Sarkissian S, Grobe JL, Yuan L, Narielwala DR, Walter GA, Katovich MJ, Raizada MK. Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology, Hypertension. 2008 March;51(3):712-718. PMID:18250366. PMCID: PMC Journal - In Process.
11. Grobe JL, Xu D, Sigmund CD. An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy, Physiology (Bethesda). 2008 August;23:187-193. PMID:18697992. PMCID: 2538674.
12. Shenov V, Grobe JL, Qi Y, Ferreira AJ, Fraga-Silva RA, Collamat G, Bruce E, Katovich MJ. 17beta-Estradiol modulates local cardiac renin-angiotensin system to prevent cardiac remodeling in the DOCA-salt model of hypertension in rats, Peptides. 2009 December;30(12):2309-2315. PMID:19747516. PMCID: PMC Journal - In Process.
13. Xu D, Borges GR, Grobe JL, Pelham CJ, Yang B, Sigmund CD. Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin, Hypertension. 2009 December;54(6):1240-1247. PMID:19822797. PMCID: 2783841. (Editoral Commentary Precedes Paper; 54(6):1216-1217, 2009)
14. Grobe JL, Grobe CL, Beltz TG, Westphal SG, Morgan DA, Xu D, de Lange WJ, Li H, Sakai K, Thedens DR, Cassis LA, Rahmouni K, Mark AL, Johnson AK, Sigmund CD. The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance, Cell Metabolism. 2010 November 3;12(5):431-442. PMID:21035755. PMCID: 2994017.
15. Grobe JL, Dickson ME, Park S, Davis DR, Born EJ, Sigmund CD. Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice, Hypertension. 2010 November;56(5):981-987. PMID:20823378. PMCID: 2959143.
16. Xu D, Borges GR, Davis DR, Agassandian K, Sequeira Lopez ML, Gomez RA, Cassell MD, Grobe JL, Sigmund CD. Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism, Physiol Genomics. 2011 March 29;43(6):286-294. PMID:21189370. PMCID: 3068515.
17. Grobe JL, Buehrer BA, Hilzendeger AM, Liu X, Davis DR, Xu D, Sigmund CD. Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice, Hypertension. 2011 March;57[Part 2}(3):600-607. PMID:21263123. PMCID: 3144490.
18. Li H, Weatherford ET, Davis DR, Keen HL, Grobe JL, Daugherty A, Cassis LA, Allen AM, Sigmund CD. Renal proximal tubule angiotensin AT1A receptors regulate blood pressure, Am J Physiol Regul Integr Comp Physiol. 2011 October;301(4):R1067-R1077. PMID:21753145. PMCID: 3197336.
19. Hilzendeger AM, Morgan DA, Brooks L, Dellsperger D, Liu X, Grobe JL, Rahmouni K, Sigmund CD, Mark AL. A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity, Am J Physiol Heart Circ Physiol. 2012 July 15;303(2):H197-H206. PMID:22610169. PMCID: 3404702.
20. Pelham CJ, Ketsawatsomkron P, Groh S, Grobe JL, de Lange WJ, Ibeawuchi S-RC, Keen HL, Weatherford ET, Faraci FF, Sigmund CD. Cullin-3 Regulates Vascular Smooth Muscle Function and Arterial Blood Pressure via PPARγ and RhoA/Rho-Kinase, Cell Metab. 2012 October 3;16(4):462-472. PMID:23040068. PMCID: 3474846.
21. Ketsawatsomkron P, Lorca RA, Keen HL, Weatherford ET, Liu X, Pelham Cj, Grobe JL, Faraci FM, England SK, Sigmund CD. PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity, Circ Res. 2012 November 9;111(11):1446-1458. PMID:22962432. PMCID: 3494760.
22. Grobe JL, Rahmouni K, Liu X, Sigmund CD. Metabolic rate regulation by the renin-angiotensin system: brain vs. body, Pflugers Arch - European J of Physiology. 2013 January;465(1):167-175. PMID:22491893. PMCID: 3569511.
23. Hilzendeger AM, Cassell MD, Davis DR, Stauss HM, Mark AL, Grobe JL, Sigmund CD. Angiotensin Type 1a Receptors in the Subfornical Organ Are Required for Deoxycorticosterone Acetate-Salt Hypertension, Hypertension. 2013 March 6;61(3):716-722. PMID:23266541. PMCID: 3573251.
24. Littlejohn NK, Siel Jr. RB, Ketsawatsomkron P, Pelham CJ, Pearson NA, Hilzendeger AM, Buehrer BA, Weidemann BJ, Li H, Davis DR, Thompson AP, Liu X, Cassell MD, Sigmund CD, Grobe JL. Hypertension in Mice with Transgenic Activation of the Brain Renin-Angiotensin System is Vasopressin-Dependent, Am J Physiol: Regul Integr Comp Physiol. 2013 May 15;304(10):R818-R828. PMID:23535460. PMCID: 3652167.
25. Burnett CM, Grobe JL. Direct calorimetry identifies deficiencies in respirometry for the determination of resting metabolic rate in C57Bl/6 and FVB mice, Am J Physiol: Endocrinol Metab. 2013 October 1;305(7):E916-E924. PMID:23964071. PMCID: 3798702.
26. Li W, Peng H, Mehaffey Ep, Kimball CD, Grobe JL, van Gool JM, Sullivan MN, Earley S, Danser AH, Ichihara A, Feng Y. Neuron-Specific (Pro)renin Receptor Knockout Prevents the Development of Salt-Sensitive Hypertension, Hypertension. 2013;63(2):316-323. PMID:24246383. PMCID: 3947277.
27. Carrillo-Supulveda MA, Keen HL, Davis DR, Grobe JL, Sigmund CD. Role of vascular smooth muscle PPARγ in regulating AT1 receptor signaling and angiotensin II-dependent hypertension, PLoS One. 2014 April 14;9(8):e103786. PMID:25122005. PMCID: 4133177.
28. Coble JP, Cassell MD, Davis DR, Grobe JL, Sigmund CD. Activation of the renin-angiotensin system, specifically in the subfornical organ is sufficient to induce fluid intake, Am J Physiol Regul Integr Comp Physiol. 2014 April 15;307(4):R376-R386. PMID:24965793. PMCID: 4137154.
29. Coble JP, Johnson RF, Cassell MD, Johnson AK, Grobe JL, Sigmund CD. Activity of protein kinase C-α within the subfornical organ is necessary for fluid intake in response to brain angiotensin, Hypertension. 2014 July;64(1):141-148. PMID:24777977. PMCID: 4057298.
30. Shi P, Grobe JL, Desland FA, Zhou G, Shen XZ, Shan Z, Liu M, Raizada MK, Sumners C. Direct pro-inflammatory effects of prorenin on microglia, PLoS One. 2014 October 10;9(10):e92937. PMID:25302502. PMCID: 4193744.
31. Santillan MK, Santillan DA, Scroggins SM, Min JY, Sandgren JA, Pearson NA, Leslie KK, Hunter SK, Zamba GK, Gibson-Corley KN, Grobe JL. Vasopressin in Preeclampsia: A Novel Very-Early Human Pregnancy Biomarker and Clinically-Relevant Mouse Model, Hypertension. 2014 October;64(4):852-859. PMID:25001273. PMCID: 4162750.
32. Ye Y, Sun Z, Guo A, Song LS, Grobe JL, Chen S. Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia., Cell Signal. 2014 November;26(11):2514-2520. PMID:25093805. PMCID: 4160384.
33. Burnett CM, Grobe JL. Dietary effects on resting metabolic rate in C57BL/6 mice are differentially detected by indirect (O2/CO2 respirometry) and direct calorimetry, Molecular Metabolism. 2014;3:460-464. PMID:24944905. PMCID: 4060218.
34. Fink BD, Herlein JA, Guo DF, Kulkarni C, Weidemann BJ, Yu L, Grobe JL, Rahmouni K, Kerns RJ, Sigmund CD. A mitochondrial-targeted coenzyme q analog prevents weight gain and ameliorates hepatic dysfunction in high-fat-fed mice, J Pharmacol Exp Ther. 2014 December;351(3):699-708. PMID:25301169. PMCID: 4244581.
35. Santillan MK, Pelham CJ, Ketsawatsomkron P, Santillan DA, Davis DR, Devor EJ, Gibson-Corley KN, Scroggins SM, Grobe JL, Yang B, Hunter SK, Sigmund CD. Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes., Physiological reports. 2015 January 19;3(1):e12257. PMID:25602015. PMCID: 4387753.
36. Jo F, Jo H, Hilzendeger AM, Thompson AP, Cassell MD, Rutkowski DT, Davisson RL, Grobe JL, Sigmund CD. Brain endoplasmic reticulum stress mechanistically distinguishes the saline-intake and hypertensive response to deoxycorticosterone acetate-salt., Hypertension (Dallas, Tex. : 1979). 2015 June 1;65(6):1341-8. PMID:25895586. PMCID: 4433403.
37. Weidemann BJ, Voong S, Morales-Santiago FI, Kahn MZ, Ni J, Littlejohn NK, Claflin KE, Burnett CM, Pearson NA, Lutter ML, Grobe JL. Dietary Sodium Suppresses Digestive Efficiency via the Renin-Angiotensin System, Scientific Reports. 2015 June 11;5:11123. PMID:26068176. PMCID: 4464075.
38. Bahr SM, Weidemann BJ, Castro AN, Walsh JW, deLeon O, Burnett CM, Pearson NA, Murry DJ, Grobe JL, Kirby JR. Risperidone-induced weight gain is mediated through shifts in the gut microbiome and suppression of energy expenditure., EBioMedicine. 2015 November 1;2(11):1725-34. PMID:26870798. PMCID: 4740326.
39. Barney CC, Schanhals EM, Grobe JL, Andresen BT, Traver M. Heat acclimation and thirst in rats, Physiological reports. 2015 December 1;3(12):e12642. PMID:26702076. PMCID: 4760436.
40. Ketsawatsomkron P, Keen HL, Davis DR, Lu KT, Stump M, De Silva TM, Hilzendeger AM, Grobe JL, Faraci FM, Sigmund CD. Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension., Hypertension (Dallas, Tex. : 1979). 2016 January 1;67(1):214-22. PMID:26597823. PMCID: 4679422.
41. Guo DF, Cui H, Zhang Q, Morgan DA, Thedens DR, Nishimura D, Grobe JL, Sheffield VC, Rahmouni K. The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane., PLoS genetics. 2016 February 29;12(2):e1005890. PMID:26926121. PMCID: 4771807.
42. Muta K, Morgan DA, Grobe JL, Sigmund CD, Rahmouni K. mTORC1 Signaling Contributes to Drinking But Not Blood Pressure Responses to Brain Angiotensin II., Endocrinology. 2016 August 1;157(8):3140-8. PMID:27254006. PMCID: 4967111.
43. Littlejohn NK, Keen HL, Weidemann BJ, Claflin KE, Tobin KV, Markan KR, Park S, Naber MC, Gourronc FA, Pearson NA, Liu X, Morgan DA, Klingelhutz AJ, Potthoff MJ, Rahmouni K, Sigmund CD, Grobe JL. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor., Cell reports. 2016 August 9;16(6):1548-60. PMID:27477281. PMCID: 4981564.
44. Boi SK, Buchta CM, Pearson NA, Francis MB, Meyerholz DK, Grobe JL, Norian LA. Obesity alters immune and metabolic profiles: New insight from obese-resistant mice on high-fat diet., Obesity (Silver Spring, Md.). 2016 October 1;24(10):2140-9. PMID:27515998. PMCID: 5039085.
45. Shinohara K, Liu X, Morgan DA, Davis DR, Sequeira-Lopez ML, Cassell MD, Grobe JL, Rahmouni K, Sigmund CD. Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension., Hypertension (Dallas, Tex. : 1979). 2016 December 1;68(6):1385-1392. PMID:27754863. PMCID: 5159235.
46. Claflin KE, Sandgren JA, Lambertz AM, Weidemann BJ, Littlejohn NK, Burnett CM, Pearson NA, Morgan DA, Gibson-Corley KN, Rahmouni K, Grobe JL. Angiotensin AT1A receptors on leptin receptor-expressing cells control resting metabolism, The Journal of Clinical Investigation. 2017 April 3;127(4):1414-1424. PMID:28263184. PMCID: 5373887.
47. Agassandian K, Grobe JL, Liu X, Agassandrian M, Thompson AP, Sigmund CD, Cassell MD. Evidence for intraventricular secretion of angiotensinogen and angiotensin by the subfornical organ using transgenic mice, Am J Physiol Regul Integr Comp Physiol. 2017;312(6):R973-R981. PMID:28490451. PMCID: 5495920.
48. Srisai D, Yin TC, Lee AA, Rouault AAJ, Pearson NA, Grobe JL, Sebag JA. MRAP2 regulates ghrelin receptor signaling and hunger sensing., Nature communications. 2017 September 28;8(1):713. PMID:28959025. PMCID: 5620068.
49. Shinohara K, Nakagawa P, Gomez J, Morgan DA, Littlejohn NK, Folchert MD, Weidemann BJ, Liu X, Walsh SA, Ponto LL, Rahmouni K, Grobe JL, Sigmund CD. Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism., Hypertension (Dallas, Tex. : 1979). 2017 November 1;70(5):990-997. PMID:28874461. PMCID: 5679092.
50. Sandgren JA, Linggonegoro DW, Zhang SY, Sapouckey SA, Claflin KE, Pearson NA, Leidinger MR, Pierce GL, Santillan MK, Gibson-Corley KN, Sigmund CD, Grobe JL. Angiotensin AT1A Receptors Expressed in Vasopressin-Producing Cells of the Supraoptic Nucleus Contribute to the Osmotic Control of Vasopressin., American journal of physiology. Regulatory, integrative and comparative physiology. 2018 January 24;314(6):R770-R780. PMID:29364700. PMCID: PMC6032302.
51. Scroggins SM, Santillan DA, Lund JM, Sandgren JA, Krotz LK, Hamilton WS, Devor EJ, Davis HA, Pierce GL, Gibson-Corley KN, Sigmund CD, Grobe JL, Santillan MK. Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia., Clinical science (London, England : 1979). 2018 February 14;132(3):419-436. PMID:29371289. PMCID: PMC5947858.
52. Sandgren JA, Deng G, Linggonegoro DW, Scroggins SM, Perschbacher KJ, Nair AR, Nishimura TE, Zhang SY, Agbor LN, Wu J, Keen HL, Naber MC, Pearson NA, Zimmerman KA, Weiss RM, Bowdler NC, Usachev YM, Santillan DA, Potthoff MJ, Pierce GL, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL. Arginine Vasopressin Infusion is Sufficient to Model Clinical Features of Preeclampsia in Mice, JCI Insight. 2018 October 4;3(19):99403. PMID:30282823. PMCID: PMC6237463.
53. Ameka M, Markan KR, Morgan DA, BonDurant LD, Idiga SO, Naber MC, Zingman LV, Grobe JL, Rahmouni K, Potthoff MJ. Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure, Scientific Reports. 2019 January 24;9(1):630. PMID:30679672. PMCID: PMC6345819.
54. Soto JE, Burnett CM, Abel ED, Grobe JL. Comparison of The Effects of High Fat Diet on Energy Flux in Mice Using Two Multiplexed Metabolic Phenotyping Systems, Obesity (Silver Spring). 2019 May;27(5):793-802. PMID: 30938081. PMCID: PMC6478533.
55. Saito K, Davis KC, Morgan DA, Toth BA, Jiang J, Singh U, Berglund ED, Grobe JL, Rahmouni K, Cui H. Celastrol Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions. Diabetes. 2019 Jun;68(6):1210-1220. PMID: 30894367. PMCID: PMC6610022.
56. Nair AR, Silva SD Jr, Agbor LN, Wu J, Nakagawa P, Mukohda M, Lu KT, Sandgren JA, Pierce GL, Santillan MK, Grobe JL, Sigmund CD. Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Protects From Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born From Pregnancies Complicated by Hypertension. Hypertension. 2019 Jul;74(1):173-183. PMID: 31104564. PMCID: PMC6561821.
57. Guo DF, Lin Z, Wu Y, Searby C, Thedens DR, Richerson GB, Usachev YM, Grobe JL, Sheffield VC, Rahmouni K. The BBSome in POMC and AgRP Neurons Is Necessary for Body Weight Regulation and Sorting of Metabolic Receptors. Diabetes. 2019 Aug;68(8):1591-1603. PMID: 31127052. PMCID: PMC6692817.
58. Perschbacher KJ, Deng G, Sandgren JA, Walsh JW, Witcher PC, Sapouckey SA, Owens CE, Zhang SY, Scroggins SM, Pearson NA, Devor EJ, Sebag JA, Pierce GL, Fisher RA, Kwitek AE, Santillan DA, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL. Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice. Hypertension. 2020 Feb;75(2):569-579. PMCID: PMC7027931
59. Segar JL, Grobe CC, Grobe JL. Fetal storage of osmotically inactive sodium. Am J Physiol Regul Integr Comp Physiol. 2020 Mar 01;318(3):R512-R514. PMCID: PMC7099460
60. Sapouckey SA, Morselli LL, Deng G, Patil CN, Balapattabi K, Oliveira V, Claflin KE, Gomez J, Pearson NA, Potthoff MJ, Gibson-Corley KN, Sigmund CD, Grobe JL. Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or agouti-related peptide. Am J Physiol Regul Integr Comp Physiol. 2020 May 01;318(5):R855-R869. PMCID: PMC7272763
61. Lueschow SR, Kern SL, Gong H, Grobe JL, Segar JL, Carlson SJ, McElroy SJ. Feeding Formula Eliminates the Necessity of Bacterial Dysbiosis and Induces Inflammation and Injury in the Paneth Cell Disruption Murine NEC Model in an Osmolality-Dependent Manner. Nutrients. 2020 Mar 26;12(4). PMCID: PMC7230818
62. Wu J, Agbor LN, Fang S, Mukohda M, Nair AR, Nakagawa P, Sharma A, Morgan DA, Grobe JL, Rahmouni K, Weiss RM, McCormick JA, Sigmund CD. Failure to vasodilate in response to salt loading blunts renal blood flow and causes salt-sensitive hypertension. Cardiovasc Res. 2021 Jan 01;117(1):308-319. PMCID: PMC7797211
63. Deng G, Morselli LL, Wagner VA, Balapattabi K, Sapouckey SA, Knudtson KL, Rahmouni K, Cui H, Sigmund CD, Kwitek AE, Grobe JL. Single-Nucleus RNA Sequencing of the Hypothalamic Arcuate Nucleus of C57BL/6J Mice After Prolonged Diet-Induced Obesity. Hypertension. 2020 Aug;76(2):589-597. PMCID: PMC7347451
64. Nakagawa P, Nair AR, Agbor LN, Gomez J, Wu J, Zhang SY, Lu KT, Morgan DA, Rahmouni K, Grobe JL, Sigmund CD. Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage. Hypertension. 2020 Aug;76(2):468-477. PMCID: PMC7347438
65. Ono-Moore KD, Rutkowsky JM, Pearson NA, Williams DK, Grobe JL, Tolentino T, Lloyd KCK, Adams SH. Coupling of energy intake and energy expenditure across a temperature spectrum: impact of diet-induced obesity in mice. Am J Physiol Endocrinol Metab. 2020 Sep 01;319(3):E472-E484. PMCID: PMC7509245
66. Nuckols VR, Holwerda SW, Luehrs RE, DuBose LE, Stroud AK, Brandt D, Betz AM, Fiedorowicz JG, Scroggins SM, Santillan DA, Grobe JL, Sigmund CD, Santillan MK, Pierce GL. Beat-to-Beat Blood Pressure Variability in the First Trimester Is Associated With the Development of Preeclampsia in a Prospective Cohort: Relation With Aortic Stiffness. Hypertension. 2020 Dec;76(6):1800-1807. PMCID: PMC7706825
67. Segar JL, Balapattabi K, Reho JJ, Grobe CC, Burnett CML, Grobe JL. Quantification of body fluid compartmentalization by combined time-domain nuclear magnetic resonance and bioimpedance spectroscopy. Am J Physiol Regul Integr Comp Physiol. 2021 Jan 01;320(1):R44-R54. PMCID: PMC7847054
68. Ye Y, Abu El Haija M, Morgan DA, Guo D, Song Y, Frank A, Tian L, Riedl RA, Burnett CML, Gao Z, Zhu Z, Shahi SK, Zarei K, Couvelard A, Poté N, Ribeiro-Parenti L, Bado A, Noureddine L, Bellizzi A, Kievit P, Mangalam AK, Zingman LV, Le Gall M, Grobe JL, Kaplan LM, Clegg D, Rahmouni K, Mokadem M. Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass. Cell Rep. 2020 Oct 27;33(4):108270. PMCID: PMC7660289
69. Zanaty M, Seara FAC, Nakagawa P, Deng G, Mathieu NM, Balapattabi K, Karnik SS, Grobe JL, Sigmund CD. β-Arrestin-Biased Agonist Targeting the Brain AT<sub>1</sub>R (Angiotensin II Type 1 Receptor) Increases Aversion to Saline and Lowers Blood Pressure in Deoxycorticosterone Acetate-Salt Hypertension. Hypertension. 2021 Feb;77(2):420-431. PMCID: PMC7855825
70. Segar JL, Grobe CC, Balapattabi K, Ritter ML, Reho JJ, Grobe JL. Dissociable effects of dietary sodium in early life upon somatic growth, fluid homeostasis, and spatial memory in mice of both sexes. Am J Physiol Regul Integr Comp Physiol. 2021 Apr 01;320(4):R438-R451. PMCID: PMC8238146
71. Gumusoglu SB, Chilukuri ASS, Hing BWQ, Scroggins SM, Kundu S, Sandgren JA, Santillan MK, Santillan DA, Grobe JL, Stevens HE. Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model. Transl Psychiatry. 2021 Jan 28;11(1):79. PMCID: PMC7844013
72. Wu J, Fang S, Lu KT, Wackman K, Schwartzman ML, Dikalov SI, Grobe JL, Sigmund CD. EP3 (E-Prostanoid 3) Receptor Mediates Impaired Vasodilation in a Mouse Model of Salt-Sensitive Hypertension. Hypertension. 2021 Apr;77(4):1399-1411. PMCID: PMC7946772
73. Rouabhi M, Guo DF, Morgan DA, Zhu Z, López M, Zingman L, Grobe JL, Rahmouni K. BBSome ablation in SF1 neurons causes obesity without comorbidities. Mol Metab. 2021 Jun;48:101211. PMCID: PMC8065214
74. Wagner VA, Clark KC, Carrillo-Sáenz L, Holl KA, Velez-Bermudez M, Simonsen D, Grobe JL, Wang K, Thurman A, Solberg Woods LC, Lehmler HJ, Kwitek AE. Bisphenol F Exposure in Adolescent Heterogeneous Stock Rats Affects Growth and Adiposity. Toxicol Sci. 2021 May 27;181(2):246-261. PMCID: PMC8163043
75. Riedl RA, Burnett CML, Pearson NA, Reho JJ, Mokadem M, Edwards RA, Kindel TL, Kirby JR, Grobe JL. Gut Microbiota Represent a Major Thermogenic Biomass. Function (Oxf). 2021;2(3):zqab019. PMCID: PMC8055641
76. Segar JL, Grobe CC, Grobe JL. Maturational changes in sodium metabolism in periviable infants. Pediatr Nephrol. 2021 Nov;36(11):3693-3698. PMCID: PMC8815317
77. De Silva TM, Modrick ML, Grobe JL, Faraci FM. Activation of the Central Renin-Angiotensin System Causes Local Cerebrovascular Dysfunction. Stroke. 2021 Jul;52(7):2404-2413. PMCID: PMC8262118
78. Nakagawa P, Gomez J, Lu KT, Grobe JL, Sigmund CD. Studies of salt and stress sensitivity on arterial pressure in renin-b deficient mice. PLoS One. 2021;16(7):e0250807. PMCID: PMC8318244
79. Xu H, Thomas MJ, Kaul S, Kallinger R, Ouweneel AB, Maruko E, Oussaada SM, Jongejan A, Cense HA, Nieuwdorp M, Serlie MJ, Goldberg IJ, Civelek M, Parks BW, Lusis AJ, Knaack D, Schill RL, May SC, Reho JJ, Grobe JL, Gantner B, Sahoo D, Sorci-Thomas MG. Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake. Arterioscler Thromb Vasc Biol. 2021 Nov;41(11):2708-2725. PMCID: PMC8551036
80. Ziegler AA, Grobe CC, Reho JJ, Jensen ES, Thulin JD, Segar JL, Grobe JL. Short-term Housing in Metabolic Caging on Measures of Energy and Fluid Balance in Male C57BL/6J Mice ( <i>Mus musculus</i>). J Am Assoc Lab Anim Sci. 2022 Mar 01;61(2):132-139. PMCID: PMC8956215
81. Herz H, Song Y, Ye Y, Tian L, Linden B, Abu El Haija M, Chu Y, Grobe JL, Lengeling RW, Mokadem M. NSAID-Induced Enteropathy Affects Regulation of Hepatic Glucose Production by Decreasing GLP-1 Secretion. Nutrients. 2021 Dec 28;14(1). PMCID: PMC8746549
82. Lozada-Fernández VV, deLeon O, Kellogg SL, Saravia FL, Hadiono MA, Atkinson SN, Grobe JL, Kirby JR. Nicotinamide Riboside-Conditioned Microbiota Deflects High-Fat Diet-Induced Weight Gain in Mice. mSystems. 2022 Feb 22;7(1):e0023021. PMCID: PMC8788325
83. Reho JJ, Nakagawa P, Mouradian GC Jr, Grobe CC, Saravia FL, Burnett CML, Kwitek AE, Kirby JR, Segar JL, Hodges MR, Sigmund CD, Grobe JL. Methods for the Comprehensive <i>in vivo</i> Analysis of Energy Flux, Fluid Homeostasis, Blood Pressure, and Ventilatory Function in Rodents. Front Physiol. 2022;13:855054. PMCID: PMC8914175
84. Patil CN, Ritter ML, Wackman KK, Oliveira V, Balapattabi K, Grobe CC, Brozoski DT, Reho JJ, Nakagawa P, Mouradian GC Jr, Kriegel AJ, Kwitek AE, Hodges MR, Segar JL, Sigmund CD, Grobe JL. Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet. Am J Physiol Regul Integr Comp Physiol. 2022 Jun 01;322(6):R467-R485. PMCID: PMC9054347
85. Oliveira V, Riedl RA, Claflin KE, Mathieu NM, Ritter ML, Balapattabi K, Wackman KK, Reho JJ, Brozoski DT, Morgan DA, Cui H, Rahmouni K, Burnett CML, Nakagawa P, Sigmund CD, Morselli LL, Grobe JL. Melanocortin MC<sub>4</sub>R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain. Physiol Genomics. 2022 Jun 01;54(6):196-205. PMCID: PMC9131927
86. Wu J, Fang S, Lu KT, Kumar G, Reho JJ, Brozoski DT, Otanwa AJ, Hu C, Nair AR, Wackman KK, Agbor LN, Grobe JL, Sigmund CD. Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension. Function (Oxf). 2022;3(3):zqac017. PMCID: PMC9045850
87. Clark KC, Wagner VA, Holl KL, Reho JJ, Tutaj M, Smith JR, Dwinell MR, Grobe JL, Kwitek AE. Body Composition and Metabolic Changes in a Lyon Hypertensive Congenic Rat and Identification of <i>Ercc6l2</i> as a Positional Candidate Gene. Front Genet. 2022;13:903971. PMCID: PMC9263446
88. Oliveira V, Reho JJ, Balapattabi K, Ritter ML, Mathieu NM, Opichka MA, Lu KT, Grobe CC, Silva SD Jr, Wackman KK, Nakagawa P, Segar JL, Sigmund CD, Grobe JL. Chronic intracerebroventricular infusion of angiotensin II causes dose- and sex-dependent effects on intake behaviors and energy homeostasis in C57BL/6J mice. Am J Physiol Regul Integr Comp Physiol. 2022 Oct 01;323(4):R410-R421. PMCID: PMC9512112
89. Mouradian GC Jr, Liu P, Nakagawa P, Duffy E, Gomez Vargas J, Balapattabi K, Grobe JL, Sigmund CD, Hodges MR. Patch-to-Seq and Transcriptomic Analyses Yield Molecular Markers of Functionally Distinct Brainstem Serotonin Neurons. Front Synaptic Neurosci. 2022;14:910820. PMCID: PMC9280690
90. Mathieu NM, Nakagawa P, Grobe CC, Reho JJ, Brozoski DT, Lu KT, Wackman KK, Ritter ML, Segar JL, Grobe JL, Sigmund CD. ARRB2 (β-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation. Hypertension. 2022 Nov;79(11):2480-2492. PMCID: PMC9669141
91. Ritter ML, Deng G, Reho JJ, Deng Y, Sapouckey SA, Opichka MA, Balapattabi K, Wackman KK, Brozoski DT, Lu KT, Paradee WJ, Gibson-Corley KN, Cui H, Nakagawa P, Morselli LL, Sigmund CD, Grobe JL. Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (<i>Rgs2</i>) From Cells Expressing Agouti-Related Peptide or the ANG (Angiotensin) II Type 1A Receptor in Mice. Hypertension. 2022 Dec;79(12):2843-2853. PMCID: PMC9649888
92. Deng Y, Dickey JE, Saito K, Deng G, Singh U, Jiang J, Toth BA, Zhu Z, Zingman LV, Resch JM, Grobe JL, Cui H. Elucidating the role of Rgs2 expression in the PVN for metabolic homeostasis in mice. Mol Metab. 2022 Dec;66:101622. PMCID: PMC9638802
93. Alexander BT, South AM, August P, Bertagnolli M, Ferranti EP, Grobe JL, Jones EJ, Loria AS, Safdar B, Sequeira-Lopez MLS, American Heart Association Council on the Kidney in Cardiovascular Disease; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Hypertension; and Council on Lifestyle and Cardiometabolic Health. Appraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and Offspring Cardiovascular Health Across the Life Course: Moving the Field Forward: A Scientific Statement From the American Heart Association. Hypertension. 2023 May;80(5):e75-e89. PMCID: PMC10242542
94. Wagner VA, Holl KL, Clark KC, Reho JJ, Dwinell MR, Lehmler HJ, Raff H, Grobe JL, Kwitek AE. Genetic background in the rat affects endocrine and metabolic outcomes of bisphenol F exposure. Toxicol Sci. 2023 Jun 28;194(1):84-100. PMCID: PMC10306406
95. Wagner VA, Deng G, Claflin KE, Ritter ML, Cui H, Nakagawa P, Sigmund CD, Morselli LL, Grobe JL, Kwitek AE. Cell-specific transcriptome changes in the hypothalamic arcuate nucleus in a mouse deoxycorticosterone acetate-salt model of hypertension. Front Cell Neurosci. 2023;17:1207350. PMCID: PMC10244568
96. Mathieu NM, Nakagawa P, Grobe JL, Sigmund CD. Insights Into the Role of Angiotensin-II AT<sub>1</sub> Receptor-Dependent β-Arrestin Signaling in Cardiovascular Disease. Hypertension. 2024 Jan;81(1):6-16. PMCID: PMC10787814
97. Grobe CC, Reho JJ, Brown-Williams D, Ziegler AA, Mathieu NM, Lawton SBR, Fekete EM, Brozoski DT, Wackman KK, Burnett CML, Nakagawa P, Sigmund CD, Segar JL, Grobe JL. Cardiometabolic Effects of DOCA-Salt in Mice Depend on Ambient Temperature. Hypertension. 2023 Sep;80(9):1871-1880. PMCID: PMC10528934
98. Balapattabi K, Yavuz Y, Jiang J, Deng G, Mathieu NM, Ritter ML, Opichka MA, Reho JJ, McCorvy JD, Nakagawa P, Morselli LL, Mouradian GC Jr, Atasoy D, Cui H, Hodges MR, Sigmund CD, Grobe JL. Angiotensin AT<sub>1A</sub> receptor signal switching in Agouti-related peptide neurons mediates metabolic rate adaptation during obesity. Cell Rep. 2023 Aug 29;42(8):112935. PMCID: PMC10530419
99. Mathieu NM, Fekete EM, Muskus PC, Brozoski DT, Lu KT, Wackman KK, Gomez J, Fang S, Reho JJ, Grobe CC, Vazirabad I, Mouradian GC Jr, Hodges MR, Segar JL, Grobe JL, Sigmund CD, Nakagawa P. Genetic Ablation of Prorenin Receptor in the Rostral Ventrolateral Medulla Influences Blood Pressure and Hydromineral Balance in Deoxycorticosterone-Salt Hypertension. Function (Oxf). 2023;4(5):zqad043. PMCID: PMC10440998
100. Ziegler AA, Lawton SBR, Grobe CC, Reho JJ, Freudinger BP, Burnett CML, Nakagawa P, Grobe JL, Segar JL. Early-life sodium deprivation programs long-term changes in ingestive behaviors and energy expenditure in C57BL/6J mice. Am J Physiol Regul Integr Comp Physiol. 2023 Nov 01;325(5):R576-R592. PMCID: PMC10866575
101. Wagner VA, Holl KL, Clark KC, Reho JJ, Lehmler HJ, Wang K, Grobe JL, Dwinell MR, Raff H, Kwitek AE. The Power of the Heterogeneous Stock Rat Founder Strains in Modeling Metabolic Disease. Endocrinology. 2023 Nov 02;164(12). PMCID: PMC10637104
102. Opichka MA, Livergood MC, Balapattabi K, Ritter ML, Brozoski DT, Wackman KK, Lu KT, Kozak KN, Wells C, Fogo AB, Gibson-Corley KN, Kwitek AE, Sigmund CD, McIntosh JJ, Grobe JL. Mitochondrial-targeted antioxidant attenuates preeclampsia-like phenotypes induced by syncytiotrophoblast-specific Gαq signaling. Sci Adv. 2023 Dec;9(48):eadg8118. PMCID: PMC10691776
103. Ritter ML, Wagner VA, Balapattabi K, Opichka MA, Lu KT, Wackman KK, Reho JJ, Keen HL, Kwitek AE, Morselli LL, Geurts AM, Sigmund CD, Grobe JL. Krüppel-like factor 4 in transcriptional control of the three unique isoforms of Agouti-related peptide in mice. Physiol Genomics. 2024 Mar 01;56(3):265-275. PMCID: PMC10866620
104. Lawton SB, Grobe CC, Reho JJ, Raff H, Thulin JD, Jensen ES, Burnett CM, Segar JL, Grobe JL. Differences in Fluid, Electrolyte, and Energy Balance in C57BL/6J Mice (<i>Mus musculus</i>) in Metabolic Caging at Thermoneutral or Standard Room Temperatures. J Am Assoc Lab Anim Sci. 2024 Mar 01;63(2):190-200. PMCID: PMC11022944
105. Reho JJ, Muskus PC, Bennett DM, Grobe CC, Burnett CML, Nakagawa P, Segar JL, Sigmund CD, Grobe JL. Modulatory effects of estrous cycle on ingestive behaviors and energy balance in young adult C57BL/6J mice maintained on a phytoestrogen-free diet. Am J Physiol Regul Integr Comp Physiol. 2024 Mar 01;326(3):R242-R253. PMCID: PMC11213288
106. Morselli LL, Amjad R, James R, Kindel TL, Kwitek AE, Williams JS, Grobe JL, Kidambi S. Diet in Food Insecurity: A Mediator of Metabolic Health? J Endocr Soc. 2024 Apr 06;8(6):bvae062. PMCID: PMC11017326
107. Mathieu NM, Tan EE, Reho JJ, Brozoski DT, Muskus PC, Lu KT, Wackman KK, Grobe JL, Nakagawa P, Sigmund CD. Genetic Deletion of β-Arrestin 2 From the Subfornical Organ and Other Periventricular Nuclei in the Brain Alters Fluid Homeostasis and Blood Pressure. Hypertension. 2024 Jun;81(6):1332-1344. PMCID: PMC11096025
108. Wildes MP, Fernando DG, Grobe CC, Reho JJ, Grobe JL, Kidambi S, Kindel TL, Kwitek AE, Segar JL, Williams JS, Morselli LL. Long-term Metabolic Dysfunction Programming in Female Mice by Serial Moderate Restriction of a High-fat High-sucrose Diet. Endocrinology. 2024 Aug 27;165(10). PMCID: PMC11408931
109. Ziegler AA, Lawton SBR, Fekete EM, Brozoski DT, Wagner VA, Grobe CC, Sigmund CD, Nakagawa P, Grobe JL, Segar JL. Early-Life Sodium Restriction Programs Autonomic Dysfunction and Salt- Sensitivity in Male C57BL/6J Mice. Am J Physiol Regul Integr Comp Physiol. 2024 Nov 16.
 
Books, Chapters, and Reviews
1. Katovich MJ, Grobe JL, Raizada MK. Gene therapy for hypertension: current targets and consideration of novel targets. In: Cardiovascular Genomics. Humana Press. 2005. p. 213-246.
2. Katovich MJ, Grobe JL, Huentelman M, Raizada MK. Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension, Exp Physiol. 2005 May;90(3):299-305. PMID:15640278.
3. Katovich MJ, Grobe JL, Raizada MK. Angiotensin-(1-7) as an antihypertensive, antifibrotic target, Curr Hypertens Rep. 2008 June;10(3):227-232. PMID:18765095.
4. Grobe JL, Venegas-Pont M, Sigmund CD, Ryan MJ. PPARgamma differentially regulates energy substrate handling in brown vs. white adipose: focus on "The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake"., Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1325-R1326. PMCID: 3597227.
5. Grobe JL, Rahmouni K. Editoral Focus: A fat contribution to RAS activation and blood pressure control: evidence from angiotensinogen conditional null mice. Focus on: "Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice, Am J Physiol: Regul Integr Comp Physiol. 2012 January 15;302(2):R242-R243. PMID:22071163.
6. Grobe JL, Rahmouni K. The adipose/circulating renin-angiotensin system cross-talk enters a new dimension, Hypertension. 2012 December;60(6):1389-1390. PMID:23108659. PMCID: 3959780.
7. Grobe JL, Sigmund CD. Another reason to eat your greens: cardiopulmonary protection by dietary delivery of angiotensin-converting enzyme-2 and angiotensin-(1-7) made in plants, Hypertension. 2014 December;64(6):1182-1183. PMID:25225201.
8. Coble JL, Grobe JL, Johnson AK, Sigmund CD. Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ, Am J Physiol Regul Integr Comp Physiol. 2015 February 15;308(4):R238-R249. PMID:25519738. PMCID: 4347751.
9. Sandgren JA, Scroggins SM, Santillan DA, Devor EJ, Gibson-Corley KN, Pierce GL, Sigmund CD, Santillan MK, Grobe JL. Vasopressin: The Missing Link for Preeclampsia?, American journal of physiology. Regulatory, integrative and comparative physiology. 2015 March 25:ajpregu.00073.2015. PMID:25810383. PMCID: 4666952.
10. Claflin KE, Grobe JL. Control of energy balance by the brain renin-angiotensin system, Current hypertension reports. 2015 May 1;17(5):38. PMID:25833461.
11. Littlejohn NK, Grobe JL. Opposing tissue-specific roles of angiotensin in the pathogenesis of obesity, and implications for obesity-related hypertension., American journal of physiology. Regulatory, integrative and comparative physiology. 2015 December 15;309(12):R1463-73. PMID:26491099. PMCID: 4698411.
12. Muntner P, Becker RC, Calhoun D, Chen D, Cowley, Jr AW, Flynn JT, Grobe JL, Kidambi S, Kotchen TA, Lackland DT, Leslie KK, Li Y, Liang M, Lloyd A, Mattson DL, Mendizabal B, Mitsnefes M, Nair A, Pierce GL, Pollock JS, Safford MM, Santillan MK, Sigmund CD, Thomas SJ, Urbina EM. Introduction to the American Heart Association's Hypertension Strategically Focused Research Network., Hypertension (Dallas, Tex. : 1979). 2016 April 1;67(4):674-80. PMID:26902490. PMCID: 5135412.
13. Sandgren JA, Santillan MK, Grobe JL. Breaking a Mother's Heart: Circulating Antiangiogenic Factors and Hypertension During Pregnancy Correlate With Specific Cardiac Dysfunctions., Hypertension (Dallas, Tex. : 1979). 2016 June 1;67(6):1119-20. PMID:27113050. PMCID: 4865412.
14. Riedl RA, Atkinson SN, Burnett CML, Grobe JL, Kirby JR. The Gut Microbiome, Energy Homeostasis, and Implications for Hypertension., Current hypertension reports. 2017 April 1;19(4):27. PMID:28316052. PMCID: 5773096.
15. Grobe JL. Comprehensive Assessments of Energy Balance in Mice. The Renin-Angiotensin-Aldosterone System: Methods and Protocols. Methods Molecular Biology Series. Springer. 2017. p. 123-146. PMID:28500600. PMCID: 5582947.
16. Sapouckey SA, Deng G, Sigmund CD, Grobe JL. Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism., Physiological genomics. 2017 December 1;49(12):722-732. PMID:28986397. PMCID: PMC5814669.
17. Morselli LL, Claflin KE, Cui H, Grobe JL. Control of Energy Expenditure by AgRP Neurons of the Arcuate Nucleus: Neurocircuitry, Signaling Pathways, and Angiotensin., Current hypertension reports. 2018 March 19;20(3):25. PMID:29556733. PMCID: PMC5882211.
18. Perschbacher KJ, Deng G, Fisher RA, Gibson-Corley KN, Santillan MK, Grobe JL. Regulators of G-Protein Signaling in Cardiovascular Function During Pregnancy., Physiological genomics. 2018 April 27;50(8):590-604. PMID:29702036. PMCID: PMC6139632.
19. Deng G, Grobe JL. The renin-angiotensin system in the arcuate nucleus controls resting metabolic rate, Current Opinion in Nephrology. 2018 December 10. PMID:30531199. PMCID: PMC6366639.
20. Nakagawa P, Gomez J, Grobe JL, Sigmund CD. The Renin-Angiotensin System in the Central Nervous System and Its Role in Blood Pressure Regulation. Curr Hypertens Rep. 2020 Jan 10;22(1):7. PMCID: PMC7101821
21. Sigmund CD, Grobe JL. A colorful view of the brain renin-angiotensin system. Hypertens Res. 2020 Apr;43(4):357-359. PMCID: PMC7107486
22. Oliveira V, Kwitek AE, Sigmund CD, Morselli LL, Grobe JL. Recent Advances in Hypertension: Intersection of Metabolic and Blood Pressure Regulatory Circuits in the Central Nervous System. Hypertension. 2021 Apr;77(4):1061-1068. PMCID: PMC7990288
23. Santillan MK, Becker RC, Calhoun DA, Cowley AW, Flynn JT, Grobe JL, Kotchen TA, Lackland DT, Leslie KK, Liang M, Mattson DL, Meyers KE, Mitsnefes MM, Muntner PM, Pierce GL, Pollock JS, Sigmund CD, Thomas SJ, Urbina EM, Kidambi S. Team Science: American Heart Association's Hypertension Strategically Focused Research Network Experience. Hypertension. 2021 Jun;77(6):1857-1866. PMCID: PMC8986150
24. Deng Y, Deng G, Grobe JL, Cui H. Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control. Front Physiol. 2021;12:691226. PMCID: PMC8274634
25. Opichka MA, Rappelt MW, Gutterman DD, Grobe JL, McIntosh JJ. Vascular Dysfunction in Preeclampsia. Cells. 2021 Nov 06;10(11). PMCID: PMC8616535
26. Araya BR, Ziegler AA, Grobe CC, Grobe JL, Segar JL. Sodium and Growth in Preterm Infants: A Review. Newborn (Clarksville). 2023;2(2):142-147. PMCID: PMC10445331
27. Opichka MA, Livergood MC, Grobe JL, McIntosh JJ. Cardiovascular Neuroendocrinology of Pregnancy Masterclass in Neuroendocrinology. 2023;14:111-135.
28. Grobe JL, Potthoff MJ. CNS Regulation of Energy Balance Handbook of Obesity - Volume 1: Epidemiology, Etiology, and Physiopathology, Fourth Edition. 1 January 2023;1:207-215.
29. Lawton SBR, Wagner VA, Nakagawa P, Segar JL, Sigmund CD, Morselli LL, Grobe JL. Angiotensin in the Arcuate: Mechanisms Integrating Cardiometabolic Control: The 2022 COH Mid-Career Award for Research Excellence. Hypertension. 2024 Nov;81(11):2209-2217. PMCID: PMC11483214
 
Patents
1. Grobe JL, Santillan MK, Santillan DA, inventors; Therapeutic strategies for the treatment of preeclampsia. United States Patent Application #20180228806; PCT/US2014/015631. United States Patent #9,937,182. (April 10, 2018).
2. Grobe JL, Santillan MK, inventors; Diagnostic tools to predict onset of preeclampsia / Method using copeptin to predict onset of preeclampsia. United States Patent Application #20150377876; PCT/US2014/015627. European Patent #2954324 (July 31, 2019).
3. Grobe JL, Santillan MK, Santillan DA, inventors; Detection of predictors of preeclampsia. United States Patent Application #20200124612; PCT/US2018/027152, Int'l filing date 11 April 2018 / priority date 11 April 2017.
4. Grobe JL, Santillan MK, Santillan DA, inventors; Early prediction of preeclampsia. United States Patent Application #20170315130. US15/583,400, priority date 01 May 2017.