CURRICULUM VITAE
Kevin R. Regner MD
Kevin R. Regner MD
Interim Chair, Professor
Department of Medicine
Division of Nephrology
Department of Medicine
Division of Nephrology
OFFICE ADDRESS: |
Hub for Collaborative Medicine |
8701 Watertown Plank Road |
Milwaukee, WI 53226 |
EDUCATION: |
1993 - 1997 BA, Purdue University, West Lafayette, IN |
1997 - 2001 MD, Medical College of Wisconsin, Milwaukee, WI |
2008 - 2011 MS, Medical College of Wisconsin, Milwaukee, WI |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
2001 - 2004 Internal Medicine Residency, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN |
2004 - 2007 Nephrology Fellowship, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN |
2009 - 2011 Clinical Research Scholars Program (NIH funded K30), Medical College of Wisconsin, Milwaukee, WI |
09/2013 - 03/2014 Medical College of Wisconsin Leadership Academy, University of Wisconsin - Milwaukee Sheldon B Lubar School of Business, Faculty Development Leadership Training Program, Milwaukee, WI |
FACULTY APPOINTMENTS: |
07/2006 - 06/2007 Instructor of Medicine, Division of Nephrology, Mayo Clinic College of Medicine, Rochester, MN |
07/2007 - 03/2013 Assistant Professor, Department of Medicine, Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI |
04/2013 - 02/2019 Associate Professor, Department of Medicine, Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI |
07/2013 - 08/2015 Interim Division Chief, Department of Medicine, Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI |
08/2013 - Present Graduate School of Biomedical Sciences
Qualified Master’s Thesis Mentor - Clinical Translational Science Program, Medical College of Wisconsin, Milwaukee, WI |
09/2015 - Present Division Chief, Department of Medicine, Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI |
03/2019 - Present Professor, Department of Medicine, Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI |
HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS: |
2007 - Present Froedtert Memorial Lutheran Hospital, Milwaukee, WI 53226 |
HOSPITAL STAFF PRIVILEGES: |
07/2007 - Present Froedtert Memorial Lutheran Hospital, Milwaukee, WI 53226 |
03/2017 - 06/2019 LifeCare Hospitals of Wisconsin, Pewaukee, WI 53072 |
SPECIALTY BOARDS AND CERTIFICATION: |
Board Certified | Issue Date | Expiration |
American Board ofInternal Medicine (ABIM) | 2004 | 12/31/2014 |
ABIM – Nephrology | 2007 | 12/31/2017 |
Licensure | Number | Issue Date | Expiration |
State of Wisconsin | 50061-020 | 01/24/2007 | 10/31/2025 |
AWARDS AND HONORS: |
1997 Phi Beta Kappa , Purdue University, West Lafayette, IN |
2000 Alpha Omega Alpha Medical Honor Society, Medical College of Wisconsin, Milwaukee WI |
2001 William W. Engstrom Award in Internal Medicine, Medical College of Wisconsin, Milwaukee, WI |
2002 Attitude, Commitment, and Excellence Award, Internal Medicine Residency, Department of Medicine, Mayo Clinic, Rochester, MN |
2004 Attitude, Commitment, and Excellence Award, Internal Medicine Residency, Department of Medicine, Mayo Clinic Internal Medicine, Rochester, MN |
2004 Outstanding Achievement Award, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN |
2007 Outstanding Achievement Award, Division of Nephrology, Mayo Clinic College of Medicine, Rochester, MN |
2009 Outstanding Medical Student Teacher Award 2008-2009, Medical College of Wisconsin, Milwaukee, WI |
2010 Central Society for Clinical Research K Award Grant, Central Society for Clinical Research & Midwestern Section of the American Federation for Medical Research |
2011 Nominee, T. Michael Bolger Standing Ovation Award, Medical College of Wisconsin, Milwaukee, WI |
2011 Outstanding Medical Student Teacher Award 2010-2011, Medical College of Wisconsin, Milwaukee, WI |
2012 Outstanding Medical Student Teacher Award 2011-2012, Medical College of Wisconsin, Milwaukee, WI |
2013 Outstanding Faculty Service Award, Research Affairs Committee, Medical College of Wisconsin, Milwaukee, WI |
2014 Outstanding Medical Student Teacher Award 2013-2014, Medical College of Wisconsin, Milwaukee, WI |
2015 Outstanding Medical Student Teacher Award 2014-2015, Medical College of Wisconsin, Milwaukee, WI |
2016 Outstanding Teaching by a Division, Internal Medicine Residency, Medical College of Wisconsin, Milwaukee, WI |
2017 Top Scores, Patient Satisfaction, Froedtert Hospital & Medical College Physicians |
2018 Outstanding Graduate School Educator 2017-2018, Graduate School of Biomedical Sciences, Medical College of Wisconsin |
2019 Best Doctors in America® 2019 - 2020 List, University of Virginia Health System |
2022 Top Doctors, MKE Lifestyle |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
2008 - Present Central Society for Clinical Research (Member) |
2009 - Present American Society of Nephrology (Fellow) |
Member (Renal Physicians Association) |
Member (National Kidney Foundation) |
Member (American College of Physicians) |
Member (International Society of Nephrology) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorial Board |
Kidney360 (American Society of Nephrology) |
Physiological Genomics |
BMC Nephrology |
Journal Review |
Mayo Clinic Proceedings |
Drug Design, Development and Therapy |
Nephron - Experimental Nephrology |
Clinical Journal of the American Society of Nephrology |
Clinical Transplantation |
International |
Journal of the American Society of Nephrology |
Journal of Cardiovascular Pharmacology and Therapeutics |
Critical Care |
American Journal of Hypertension |
Apoptosis |
FASEB Journal |
Journal of Urology |
American Journal of Physiology-Renal Physiology |
BMC Nephrology |
International Journal of Nephrology |
Journal of Hypertension |
American Journal of Physiology-Gastrointestinal and Liver Physiology |
Circulation: Cardiovascular Genetics |
International Journal of Urology |
Scientific Reports |
Annals of Transplantation |
BMC Research Notes |
Kidney360 |
PLOS ONE |
Prostaglandins and Other Lipid Mediators |
American Journal of Medical Sciences |
Medical Science Monitor |
LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
07/2009 - 05/2010 Member, Wisconsin Chronic Kidney Disease Task Force, National Kidney Foundation of Wisconsin |
09/2010 Member, Grant Review Panel, Clinical and Translational Science Institute of Southeast Wisconsin |
09/2011 Member, Grant Review Panel, Clinical and Translational Science Institute of Southeast Wisconsin |
09/2012 Member, Grant Review Panel, Clinical and Translational Science Institute of Southeast Wisconsin |
07/2015 Member, Research and Education Program Grant Review Panel, Advancing a Healthier Wisconsin Endowment |
05/2018 Member, Cardiovascular Center Research Grant Review Panel, Medical College of Wisconsin |
06/2018 Member, Clinical and Population Health Grant Review Panel, Advancing a Healthier Wisconsin Endowment, Research and Education Program |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
04/2014 Member, Clinical Trial Grant Application Review Panel, FDA Orphan Products Grants Program |
10/2016 Member, Institute for Clinical and Translational Science Grant Review Panel, University California Irvine |
04/2017 Member, Clinical Trial Grant Application Review Panel, FDA Orphan Products Grants Program |
12/2017 Member, Clinical Trial Grant Application Review Panel, FDA Orphan Products Grants Program |
05/2018 Member, FDA Orphan Products Grants Program, Clinical Trial Grant Application Review Panel |
10/2018 Consultant, Advisory Board, Mallinckrodt Pharmaceuticals Nephrology (Hepatorenal Syndrome) |
05/2019 Member, Innovational Research Incentive Grant Review Panel, The Netherlands Organization for Health Research and Development |
09/2019 Member, National Dialogue on Hepatorenal Syndrome – Type 1 Panel, American Liver Foundation and National Kidney Foundation Washington, DC |
11/2019 Member, Clinical Trial Grant Application Review Panel, FDA Orphan Products Grants Program |
01/2020 Member, Organ Basic Sciences 2 Review Panel, AHA Career Development Award Grants Program |
04/2020 - Present Member, Executive Council, Central Society for Clinical and Translational Research (CSCTR) |
09/2020 - Present Founding Member, Hepatorenal Syndrome Multi-Center Academic Collaborative (HARMONRY) |
10/2020 Panel Member, Hepatorenal Syndrome Summit, Chronic Liver Disease Foundation, Dallas, TX |
10/2021 Pannel Member, Hepatorenal Syndrome Summit, Chronic Liver Disease Foundation, Las Vegas, NV |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
"Role of 20-HETE in renal ischemia-reperfusion injury", The 12th International Winter Eicosanoid Conference, Baltimore, MD, 03/10/2010 |
"G Proteins, Ligand & Biased Agonists: Unconventional Mechanisms of Signal Processing", American Society of Nephrology’s Kidney Week 2016, Chicago, IL, 11/2016 |
"Hepatobiliary System Failure and AKI: A Challenging Combination", American Society of Nephrology’s Kidney Week 2017, New Orleans, LA, 11/2017 |
"Genetic Predictors of Acute Kidney Injury", Kidney Con 2019, University of Arkansas College of Medicine, 04/13/2019 |
"To Dialyze or Not to Dialyze? The Great Debate: Use of Renal Replacement Therapy in Patients with Acute Kidney Injury in the Context of Cirrhosis", National Kidney Foundation (NKF) 2019 Spring Clinical Meetings, Boston, MA, 05/2019 |
"Overview of HRS/AKI: Recent Developments in Evaluation, Diagnosis and Management", National Kidney Foundation (NKF) 2019 Spring Clinical Meetings, Boston, MA, 05/2019 |
“Management Strategies for Maintaining Renal Function in HRS Type 1”, National Kidney Foundation (NKF) 2020 Spring Clinical Meetings, New Orleans, LA (Virtual due to COVID-19 Pandemic), 03/2020 |
“Transplanting New Guidelines Into Practice in Hepatorenal Syndrome and Acute Kidney Injury Everything Is Fixed, Right?”, National Kidney Foundation (NKF) 2020 Spring Clinical Meetings, New Orleans, LA (Virtual due to COVID-19 Pandemic), 03/2020 |
“Hepatorenal Syndrome Type 1: Advances in Management”, American Society of Nephrology’s Kidney Week 2021, San Diego, CA, 11/2021 |
“Comparison of Vasoconstrictors in Cirrhosis-Associated AKI”, American Society of Nephrology’s Kidney Week 2021, San Diego, CA, 11/2021 |
“Real World Challenges in Hepatorenal Syndrome: A Case Discussion on Advancements in Care”, Medscape Live Hybrid Program at Society of Hospital Medicine Converge, Austin, TX, 03/2023 |
“Evidence-Based Vasopressor Use in HRS/AKI: Guidelines for Managing Multiorgan Failure in Acute-on-Chronic Liver Failure (ACLF)”, National Kidney Foundation (NKF) 2023 Spring Clinical Meetings, Austin TX, 04/2023 |
“Vasopressor use in HRS/AKI: Patient Selection, Monitoring and Safety Challenges”, National Kidney Foundation (NKF) 2023 Spring Clinical Meetings, Austin, TX, 04/2023 |
Local |
"Role of 20-HETE in renal ischemia-reperfusion injury", Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, 07/14/2010 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
10/2008 - 10/2010 Member, Intern selection committee, Department of Medicine |
10/2009 - Present Member, Nephrology Fellow Selection Committee, Division of Nephrology, Department of Medicine |
07/2010 - Present Member, Clinical and Translational Science Master’s Program Advisory Committee, Graduate School of Biomedical Sciences |
09/2011 - 2014 Member, Research Affairs Committee |
10/2011 - Present Member, Honorary Degree/Commencement Speaker Selection Committee |
05/2012 - 07/2013 Members, Discovery Curriculum Evaluation Sub-Group of the Discovery Curriculum Steering Committee |
02/2013 - 02/2014 Member, Foundations Awards Committee Task Force |
02/2015 - Present Member, Clinical & Translational Science Institute Mentoring Committee |
01/2017 - 06/2018 Chair, Search Committee, Division of Cardiovascular Medicine Chief and Heart & Vascular Service Line Director |
07/2018 - Present Chair, Precision Medicine Champions group, Department of Medicine |
04/2019 - Present Pharmacogenomics Precision Medicine Steering Committee, Medical College of Wisconsin |
06/2021 - 12/2021 Member, Search Committee, Division of Geriatrics Chief, Department of Medicine |
07/2021 - 06/2023 Member, MCP Compensation Committee |
10/2021 - 10/2022 Member, Search Committee, Division of Hematology/Oncology Chief, Department of Medicine |
12/2021 - 03/2023 Member, Search Committee, Transplant Service Line Director |
Hospital |
07/2008 - 06/2010 Central Line Committee, Froedtert Memorial Lutheran Hospital, Milwaukee WI |
07/2008 - 06/2009 Advance Care Initiative, Standard and Quality Improvement Workgroup, Froedtert Memorial Lutheran Hospital, Milwaukee, WI |
MCW TEACHING ACTIVITIES: |
Medical Student Education |
2007 - Present Attending Physician, Nephrology Inpatient or Consult Service (Third and fourth year medical students) |
2008 - 2009 Preceptor, Clinical Examination & Reasoning (CER) Course (Second year medical students) |
2009 - Present “Tubulointerstitial Diseases of the Kidney” Pathology Course (Second year medical students) |
2009 - Present “Chronic Kidney Disease and Vascular Diseases of the Kidney” Pathology Course (Second year medical students) |
2009 - Present “Inherited and Cystic Diseases of the Kidney” Pathology Course (Second year medical students) |
2009 - Present “Review of Renal Pathology” Pathology Course (Second year medical students) |
2009 - Present “Nephrolithiasis and Obstructive Diseases of the Kidney” Pathology Course (Second year medical students) |
2009 - Present “Glomerular Diseases of the Kidney” Pathology Course (Second year medical students) |
2010 - Present “Nephrology” MKSAP 4 - Internal medicine clerkship board review session (Third year medical students) |
2010 - Present Mentor, Cultural Sensitivity Skills Program (Second year medical students) |
2011 - Present “Management of common electrolyte disorders” Internal medicine clerkship lecture series (Third year medical students) |
2011 - Present Small group facilitator, Physician Scientist Pathway (Second year medical students) |
2011 “Acute Kidney Injury” Team based learning small group session (First year medical students) |
2011 “Acute Kidney Injury” Team based learning small group session (First year medical students) |
2012 “Hematuria” Team based learning symptoms module (Second year medical students) |
2012 - Present Renal/Respiratory Expert Panel
Discovery Curriculum
|
2012 Mentor, Clinical Apprenticeship Program |
2012 Small group facilitator, Clinical and Translational Research Intercession (Third year medical students) |
2016 M3 Bite-Size Teaching Session facilitator |
Graduate Student Education |
2011 - Present Course Director, Introduction to Clinical Translational Research Course, Clinical Translational Science Master’s Program
|
Resident and Fellow Education |
2007 - Present Attending Physician, Inpatient Nephrology or Consult Service |
2007 - 2009 “Basics of Kidney Disease: Glomerular, Interstitial, and Cystic Diseases of the Kidney” Nephrology lecture series for trainees on Nephrology rotation |
2007 - Present Nephrology case conference facilitator Nephrology residents and fellows |
2008 “Renal Replacement Therapy for Acute Kidney Injury” Pulmonary Critical Care Fellows Seminar |
2009 “Renal Amyloidosis” Clinical-Pathologic Conference Department of Medicine |
2009 - Present Continuity clinic preceptor Nephrology fellows’ outpatient clinic |
2009 “Evaluation and management of electrolyte abnormalities in the acute care setting” Academic Half Day - Internal Medicine Residents |
2009 - Present “Continuous Renal Replacement Therapy for Acute Kidney Injury and Electrolyte Disorder” Critical Care Residents Seminar |
02/02/2010 “Urinary Exosomes in Polycystic Kidney Disease” Nephrology Research Conference |
07/27/2010 “Role of Mitochondrial Autophagy in Aging Kidneys” Nephrology Journal Club |
08/25/2010 “AKI and Renal Replacement Therapies in the ICU”Summer core curriculum for Intensive Care fellows again |
11/30/2010 “Role of Klotho in Acute Kidney Injury” Nephrology Journal Club |
2010 “Glomerular Diseases” Academic Half Day - Internal Medicine Residents |
2010 “Continuous Renal Replacement Therapy” Nephrology Fellows’ Core Curriculum |
2013 - Present “Renal Biopsy Conference” Division of Nephrology |
2014 “IgA Nephropathy Presenting as Pre-eclampsia” Clinical-Pathologic Conference |
Continuing Medical Education |
09/04/2007 “Continuous Renal Replacement Therapy: Targeting Optimal Dose” Division of Nephrology Research Conference |
11/09/2007 “Continuous Renal Replacement Therapy for Critical Care RNs” Critical Care Nurse Education |
12/14/2007 “Diagnosis and management of dysnatremias in the acute care setting” Pulmonary & Critical Care division weekly conference |
02/01/2008 “Renal replacement therapy for acute kidney injury: current controversies and future directions” Department of Medicine Grand Rounds |
10/21/2008 “Protective effect of 20-HETE analogues in renal ischemia-reperfusion injury” Nephrology Research Conference |
2008 “Acute Kidney Injury for Nephrology Nurses” Lecture series for Nephrology Nursing Staff |
01/27/2009 “Endothelial to mesenchymal transition in renal fibrosis” Nephrology Research Conference |
01/20/2010 “Acute kidney injury and cardiovascular disease” Cardiology Grand Rounds |
02/16/2010 “Role of 20-HETE in renal ischemia-reperfusion injury” Nephrology Research Conference |
02/18/2010 “Urinary exosomes: a source of biomarkers in polycystic kidney disease” Population Health Research Seminar |
04/19/2010 “Experimental treatments for acute kidney injury” Cardiovascular Center Advisory Board Meeting |
04/21/2010 “Role of 20-HETE in renal ischemia-reperfusion injury” Clinical Translational Science Institute |
06/2011 “Mechanisms of Renal Regeneration in Acute Kidney Injury” Solid Organ Transplant Center Grand Rounds |
10/2011 “Advances in Acute Kidney Injury” 1st Annual MCW Nephrology Review and Update |
10/2011 “Continuous Renal Replacement Therapy” 1st Annual MCW Nephrology Review and Update |
10/2011 “Interesting Glomerular Disease Cases” 1st Annual MCW Nephrology Review and Update |
02/2012 “Mechanisms of Renal Regeneration in Acute Kidney Injury” Nephrology-Transplant Research Grand Rounds |
05/2012 “Mechanisms of Renal Tubular Regeneration in AKI” CVC/KDC Seminar Series |
09/2012 “Continuous Renal Replacement Therapy” 2nd Annual MCW Nephrology Review and Update |
09/2012 “Interesting Glomerular Disease Cases” 2nd Annual MCW Nephrology Review and Update |
2012 - 2014 Small group preceptor, K30 Clinical Research Scholars Program |
01/2013 “Pathophysiology of Acute Kidney Injury: A Case-Based Update”
Department of Medicine Grand Rounds |
04/2016 “Acute kidney injury in liver disease”
Department of Medicine Grand Rounds |
09/2016 “Kidney injury in liver disease” Solid Organ Transplant Center Research Conference
|
03/2017 “Differential Susceptibility to acute kidney injury in heterogeneous stock rats.” Department of Medicine 3rd Annual Research Retreat |
03/2018 “Do Genes Matter in Acute Kidney Injury” Nephrology Research Conference |
03/2018 “Do Genes Matter in Acute Kidney Injury” Nephrology Research Conference |
03/2019 “Do Genes Matter in Acute Kidney Injury” Featured Speaker, Department of Medicine 4rd Annual Research Retreat |
04/2019 “SGLT2 Inhibitors in CKD and Type 2 Diabetes: Nephrology Research Conference |
04/2020 “COVID-19 Virtual Grand Rounds: COVID-19 and the Kidney”, Department of Medicine, Medical College of Wisconsin |
08/2023 “Evaluation and Management of AKI in Patients with Cirrhosis” Division of Nephrology, Medical College of Wisconsin |
EXTRAMURAL TEACHING: |
Resident and Fellow Education |
09/06/2011 Nephrology Journal Club, “Biomarkers and Renal Recovery after Acute Kidney Injury” |
11/30/2011 Nephrology Journal Club, “Biomarkers and Renal Recovery after Acute Kidney Injury” |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Medical Students |
06/2010 - 06/2011 Brodie Marthaler, Research mentor (T35 Training Grant from NHLBI), MCW |
07/2013 - 10/2013 Lindsay R. Hammons, Research Advisor, MCW |
07/2013 - 10/2013 Andrew Chong, Research Mentor, MCW |
07/2013 - 06/2017 Paul Hanna, Research Mentor, MCW |
07/2013 - 06/2017 Seth J Davis, Research Advisor, MCW |
07/2013 - 10/2013 Michael R Bergquist, Research Advisor, MCW |
01/2014 - 05/2015 Mirza Khan, Clinical Advisor, MCW |
04/2015 - 06/2018 David Charles, Research Mentor, MCW |
07/2015 - 10/2015 Hector Lopez, Research Advisor, MCW |
07/2015 - 10/2015 Thomas LoDuca, MCW, MCW |
07/2015 - 10/2015 Shen Wang, Research Advisor, MCW |
07/2015 - 10/2015 Paul Merchant, Research Advisor, MCW |
07/2016 - 10/2016 Kristen Winsor, Research Advisor, MCW |
07/2016 - 07/2017 Sam Kortes, Reseach Mentor, MCW |
07/2016 - 10/2016 Scott Sandy, Research Advisor, MCW |
07/2016 - 10/2016 Shoshana Blumenthal, Research Advisor, MCW |
07/2016 - 10/2016 Sean Gallagher, Research Advisor, MCW |
07/2017 - 10/2017 Daniel Kadden, Research Advisor, MCW |
07/2017 - 10/2017 Matthew Gonzalez, Research Advisor, MCW |
07/2017 - 10/2017 Brian Kenealy, Research Advisor, MCW |
07/2017 - Present Elijah Bowen, Research Mentor, MCW |
07/2017 - 10/2017 Sean Huls, Research Advisor, MCW |
07/2018 - Present Jonathan Katz, Research Awards, MCW |
07/2018 - Present David Holzer, Research Advisor, MCW |
07/2018 - Present Garrett Berger, Research Mentor, MCW |
07/2018 - Present Giulia Taccheri, Research Advisor, MCW |
07/2018 - Present Nava Lalehzari, Research Mentor, MCW |
Graduate Students |
PhD Committees |
09/2013 - 06/2015 Brad Endres, MCW |
04/2018 - 05/2020 Anna Williams, MCW |
05/2019 - Present Victoria Nasci, MCW |
Clinical/Research Fellows |
10/2007 - 06/2008 Aaron Dall, MD, Research advisor, MCW |
04/2009 - 11/2009 Lakshmi Raman, MD, Research advisor, MCW |
04/2010 - 06/2011 Mohammed Saleh, MD, Research Mentor, MCW |
04/2011 - Present Kumar Shrishramal, MD, Research advisor, MCW |
07/2012 - 06/2011 Emily Haines, DO, Research Mentor, MCW |
07/2016 - 06/2017 David Houser, MD, Research Mentor, MCW |
01/2018 - Present Krishna Keri, MD, Research Mentor, MCW |
Residents |
10/2007 - 06/2009 Ammar Haque, MD, Research advisor, MCW |
Faculty |
08/2010 - Present Afzal Usman, MD, Research mentor, MCW |
09/2012 - 07/2014 David Hehir, MD, MS Thesis Committee, MCW |
07/2013 - Present Dawn Wolfgram, Grant Mentor, MCW |
07/2016 - Present Banani Banerjee PhD, Mentorship Committee, MCW |
07/2016 - 01/2021 Grand Mentor, Grant mentor, MCW |
02/2018 - Present Mukoso Ozieh MD, MS, MCW |
03/2021 - 01/2023 Sherry Ann Brown MD, PhD, Grant Mentor, MCW |
07/2021 - Present Anna Gaddy, MD, Research Mentor, MCW |
PROGRAMMATIC DEVELOPMENTS: |
Educational Programs |
Student |
2011 Developed critical care nephrology e-curriculum for nephrology fellowship program |
Fellow |
2007 Developed critical care nephrology e-curriculum for nephrology fellowship program |
Clinical Programs |
2007 - Present Developed multidisciplinary continuous renal replacement therapy working group |
COMMUNITY SERVICE ACTIVITIES: |
2009 Coordinated a National Kidney Foundation "Kidney Early Evaluation Program" in collaboration with the Wisconsin chapter of the NKF. |
2010 Coordinated a National Kidney Foundation "Kidney Early Evaluation Program" in collaboration with the Wisconsin chapter of the NKF. |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Cohen EP, Regner K, Fish BL, Moulder JE. Stenotic glomerulotubular necks in radiation nephropathy. J Pathol 2000;190:484-488. |
2. Moulder JE, Fish BL, Regner KR, Cohen EP, Raife TJ. Retinoic acid exacerbates experimental radiation nephropathy. Radiat Res 2002;57:199-203. |
3. Moulder JE, Fish BL, Regner KR, Cohen EP. Angiotensin II blockade reduces radiation-induced proliferation in experimental radiation nephropathy. Radiat Res 2002;157:393-401. |
4. Regner KR, Riegert-Johnson DL, Volcheck GW. Serial measurement of serum tryptase in angiotensin-converting enzyme inhibitor-associated angioedema. Mayo Clin Proc. 2003 May;78(5):655-6. |
5. Ensminger SA, Regner KR, Froehling DA. 35-Year-Old Woman with fever, cough, and anorexia. Mayo Clin Proc 2003;78:753-756. |
6. Regner, KR, Connolly, HM, Schaff, HV, Albright, RC. Acute renal failure after cardiac surgery for carcinoid heart disease: Incidence, risk factors, and prognosis. Am J Kid Dis 2005; 45:826-823. |
7. Priester TC, Khoo T, Fernández-Pérez ER, Regner KR, Tracy JA, Mitchell S, Summar ML, Babovic-Vuksanovic D. Hyperammonemia from a urea cycle disorder presenting in adulthood The Open Crit Care Med J. . |
8. Regner KR, Zuk A, Shames BD, Van Why SK, Ryan RP, Falck JR, Manthati VL, Roman RJ. Protective effect of 20-HETE analogues in experimental renal ischemia-reperfusion injury. Kidney Int. 2009 Mar;75(5):511-517. |
9. Liang H, Hilton G, Regner KR, Johnson CP, Nilakantan V. MnTmPyP, a cell permeable SOD mimetic, reduces oxidative stress and apoptosis induced by renal ischemia-reperfusion injury in vivo. Am J Physiol Renal Physiol. 2009:296:F266-276. |
10. Akbulut T, Regner KR, Roman RJ, Avner ED, Falck JR, Park F. 20-HETE activates the Raf/MEK/ERK pathway in the renal epithelial cells through EGFR- and c-Src-dependent mechanism. Am J Physiol Renal Physiol 2009; 297:F662-F670. PMID: 19570883 |
11. Solberg-Woods L, Stelloh C, Regner KR, Schwabe T, Eisenhauer J, Garrett MR. Heterogenous stock rats - a new animal model to study the genetics of renal injury. Am J Physiol Renal Physiol 2010; 298:F1484-91. PMID: 20219828 |
12. Ionova IA, Vasquez-Vivar J, Cooley BC, Khanna AK, Whitsett J, Herrnreiter A, Migrino RQ, Ge Z, Regner KR, Channon KM, Alp NJ, Pieper GM. Cardiac Myocyte-Specific Over-expression of Human GTP Cyclohydrolase I Protects Against Acute Cardiac Allograft Rejection. Am J Physiol Heart Circ Physiol. 2010; 299:H88-96. PMID: 20418482 |
13. Regner KR, Nilakantan V, Mortenson J, White SM, Ryan RP, Roman RJ. Protective Effect of Lifor Solution in Experimental Renal Ischemia-Reperfusion Injury. J Surg Research 2010;164:e291-297. PMID: 20888590. |
14. Regner KR, Nozu K, Lanier SM, Blumer JB, Avner ED, Sweeney, Jr WE, Park F. Loss of Activator of G Protein Signaling 3 Impairs Renal Tubular Regeneration Following Acute Kidney Injury in Rodents. FASEB Journal 2011; PMID: 21343176 |
15. Buelow MW, Dall A, Regner K, Weinberg C, Bartz PJ, Sowinski J, Rudd N, Katzmark L, Tweddell JS, Earing MG. Urinary interleukin-18 and urinary neutrophil gelatinase-associated lipocalin predict acute kidney injury following pulmonary valve replacement prior to serum creatinine. Congenit Heart Dis. 2012;7(5):441-7. |
16. Regner KR, Harmon AC, Williams JM, Stelloh C, Johnson AC, Kyle PB, Lerch-Gaggl A, White SM, Garrett MR. Increased susceptibility to kidney injury by transfer of genomic segment from SHR onto Dahl S genetic background. Physiol Genomics. 2012 Jun 15;44(12):629-37. PMCID: PMC3426430 |
17. Williams JM, Johnson AC, Stelloh C, Dreisbach AW, Franceschini N, Regner KR, Townsend RR, Roman RJ, Garrett MR. Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat. Hypertension. 2012 Nov;60(5):1157-68. PMCID: PMC3505884 |
18. Oltrogge KM, Peppard WJ, Saleh M, Regner KR, Herrmann DJ. Phenytoin removal by continuous venovenous hemofiltration. Ann Pharmacother. 2013 Sep;47(9):1218-22. |
19. Westbrook L, Johnson AC, Regner KR, Williams JM, Mattson DL, Kyle PB, Henegar JR, Garrett MR. Genetic susceptibility and loss of Nr4a1 enhances macrophage-mediated renal injury in CKD. J Am Soc Nephrol. 2014 Nov;25(11):2499-510. PMCID: PMC4214519 |
20. Tabatabai NM, North PE, Regner KR, Kumar SN, Duris CB, Blodgett AB. De novo expression of sodium-glucose cotransporter SGLT2 in Bowman's capsule coincides with replacement of parietal epithelial cell layer with proximal tubule-like epithelium. J Membr Biol. 2014 Aug;247(8):675-83. PMCID: PMC4117812 |
21. White SM, North LM, Haines E, Goldberg M, Sullivan LM, Pressly JD, Weber DS, Park F, Regner KR. G-protein βγ subunit dimers modulate kidney repair after ischemia-reperfusion injury in rats. Mol Pharmacol. 2014 Oct;86(4):369-77. PMCID: PMC4164983 |
22. Lenarczyk M, Pressly JD, Arnett J, Regner KR, Park F. Localization and expression profile of Group I and II Activators of G-protein Signaling in the kidney. J Mol Histol. 2015 Apr;46(2):123-36. PMCID: PMC4369180 |
23. Muroya Y, Fan F, Regner KR, Falck JR, Garrett MR, Juncos LA, Roman RJ. Deficiency in the Formation of 20-Hydroxyeicosatetraenoic Acid Enhances Renal Ischemia-Reperfusion Injury. J Am Soc Nephrol. 2015 Oct;26(10):2460-9. PMCID: PMC4587700 |
24. Rasmussen SA, Kwon M, Pressly JD, Blumer JB, Regner KR, Park F. Activator of G-protein Signaling 3 Controls Renal Epithelial Cell Survival and ERK5 Activation. J Mol Signal. 2015 Nov 27;10:6. PMCID: PMC4831271 |
25. Zimmerman MA, Selim M, Kim J, Regner K, Saeian K, Zanowski S, Martin A, Connolly LA, Lauer KK, Woehlck HJ, Hong JC. Outcome analysis of continuous intraoperative renal replacement therapy in the highest acuity liver transplant recipients: A single-center experience. Surgery. 2017 May;161(5):1279-1286. |
26. Pressly JD, Hama T, Brien SO, Regner KR, Park F. TRIP13-deficient tubular epithelial cells are susceptible to apoptosis following acute kidney injury. Sci Rep. 2017 Mar 03;7:43196. PMCID: PMC5335694 |
27. Baker MA, Davis SJ, Liu P, Pan X, Williams AM, Iczkowski KA, Gallagher ST, Bishop K, Regner KR, Liu Y, Liang M. Tissue-Specific MicroRNA Expression Patterns in Four Types of Kidney Disease. J Am Soc Nephrol. 2017 Oct;28(10):2985-2992. PMCID: PMC5619963 |
28. Keri KC, Regner KR, Dall AT, Park F. Urinary exosomal expression of activator of G protein signaling 3 in polycystic kidney disease. BMC Res Notes. 2018 Jun 07;11(1):359. PMCID: PMC5992714 |
29. Liu Y, Usa K, Wang F, Liu P, Geurts AM, Li J, Williams AM, Regner KR, Kong Y, Liu H, Nie J, Liang M. MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension. J Am Soc Nephrol. 2018 Oct;29(10):2518-2528. PMCID: PMC6171279 |
30. Cheng Y, Wang D, Wang F, Liu J, Huang B, Baker MA, Yin J, Wu R, Liu X, Regner KR, Usa K, Liu Y, Zhang C, Dong L, Geurts AM, Wang N, Miller SS, He Y, Liang M. Endogenous miR-204 Protects the Kidney against Chronic Injury in Hypertension and Diabetes. J Am Soc Nephrol. 2020 Jul;31(7):1539-1554. PMCID: PMC7350998 |
31. Bhasin B, Veitla V, Dawson AZ, Garacci Z, Sturgill D, Ozieh MN, Regner KR. AKI in Hospitalized Patients with COVID-19 and Seasonal Influenza: A Comparative Analysis. Kidney360. 2021 Apr 29;2(4):619-628. PMCID: PMC8791326 |
32. Allegretti AS, Parada XV, Endres P, Zhao S, Krinsky S, St Hillien SA, Kalim S, Nigwekar SU, Flood JG, Nixon A, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Regner KR, Belcher JM, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT, HRS-HARMONY study investigators. Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study. Clin Transl Gastroenterol. 2021 May 11;12(5):e00359. PMCID: PMC8116001 |
33. Belcher JM, Parada XV, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Sharma P, Regner KR, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT, Allegretti AS, HRS-HARMONY Study Investigators. Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward. Am J Kidney Dis. 2022 May;79(5):737-745. |
34. Hama T, Nagesh PK, Chowdhury P, Moore BM 2nd, Yallapu MM, Regner KR, Park F. DNA damage is overcome by TRIP13 overexpression during cisplatin nephrotoxicity. JCI Insight. 2021 Nov 22;6(22). PMCID: PMC8663775 |
35. Swanson ML, Regner KR, Moore BM 2nd, Park F. Cannabinoid Type 2 Receptor Activation Reduces the Progression of Kidney Fibrosis Using a Mouse Model of Unilateral Ureteral Obstruction. Cannabis Cannabinoid Res. 2022 Dec;7(6):790-803. |
36. Williams AM, Jensen DM, Pan X, Liu P, Liu J, Huls S, Regner KR, Iczkowski KA, Wang F, Li J, Gallan AJ, Wang T, Baker MA, Liu Y, Lalehzari N, Liang M. Histologically resolved small RNA maps in primary focal segmental glomerulosclerosis indicate progressive changes within glomerular and tubulointerstitial regions. Kidney Int. 2022 Apr;101(4):766-778. PMCID: PMC8940673 |
37. Miller B, Regner K, Sorokin A. p66Shc signaling does not contribute to tubular damage induced by renal ischemia-reperfusion injury in rat Biochemical and Biophysical Research Communications. 7 May 2022;603:69-74. |
38. Regner KR, Kanduri SR, Velez JCQ. Management of AKI in patients with cirrhosis . Curr Treat Options Gastro 2022; 20:295-315. . |
39. Velez JCQ, Karakala N, Tayebi K, Wickman TJ, Mohamed MMB, Kovacic RA, Therapondos G, Kanduri SR, Allegretti AS, Belcher JM, Regner KR, Wentowski C. Responsiveness to Vasoconstrictor Therapy in Hepatorenal Syndrome Type 1. Kidney360. 2023 Apr 01;4(4):e448-e456. PMCID: PMC10278824 |
40. Swanson M, Yun J, Collier DM, Seif C, Yang CY, Regner KR, Park F. Identification of cell division cycle protein 20 in various forms of acute and chronic kidney injury in mice. Am J Physiol Renal Physiol. 2023 Aug 01;325(2):F248-F261. |
41. Koratala A, Paudel HR, Regner KR. Nephrologist-Led Simulation-Based Focused Cardiac Ultrasound Workshop for Medical Students: Insights and Implications American Journal of Medicine Open. 2023 Dec;10: 2667-0364. |
42. Patidar KR, Belcher JM, Regner KR, St Hillien SA, Simonetto DA, Asrani SK, Neyra JA, Sharma P, Velez JCQ, Wadei H, Nadim MK, Chung RT, Seethapathy R, Parada XV, Ouyang T, Ufere NN, Robinson JE, McLean Diaz P, Wilechansky RM, Przybyszewski EM, Smith TN, Ali AA, Orman ES, Schulz P, Siddiqui SM, Shabbir R, Liu LJ, Cama-Olivares A, Flannery AH, Baker ML, Gunasekaran D, Aswine A, Issa R, Li J, Verma S, Chalmers D, Varghese V, Lam W, Mohamed M, Kovacic R, Gaddy A, Attieh RM, Cortes P, Semnani S, Wang L, Khemichian S, Allegretti AS, from the HRS-HARMONY consortium. Incidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the US. J Hepatol. 2023 Dec;79(6):1408-1417. PMCID: PMC10807505 |
Books, Chapters, and Reviews |
1. Regner KR. Epidemiology of acute kidney injury after cardiac surgery: an update. Journal of Organ Dysfunction 2007;3(4):232-239. *Invited review. |
2. Regner KR and Roman RJ. Role of renal medullary hemodynamic in ischemia-reperfusion injury. Curr Opin Nephrol Hypertens. In prepration. *Invited review. |
3. Ratkalkar V and Regner KR. Approach to the Patient with Hematuria, In: Clinical Decision Making in Nephrology, Hypertension, and Renal Transplantation: A Problem-Solving Approach. E Lerma and M Rosner Eds. Springer. Submitted. |
4. Regner KR, Singbartl K. Kidney Injury in Liver Disease. Crit Care Clin. 2016 Jul;32(3):343-55. |
5. Williams AM, Liu Y, Regner KR, Jotterand F, Liu P, Liang M. Artificial intelligence, physiological genomics, and precision medicine. Physiol Genomics. 2018 Apr 01;50(4):237-243. PMCID: PMC5966805 |
Editorials, Letters To Editor, Other |
1. Regner KR, Riegert-Johnson DL, Volcheck GW. Serial Measurement of Serum Tryptase Levels in Angiotensin Converting Enzyme Inhibitor Associated Angioedema. Mayo Clin Proc 2003; 78:655-656. PMID: 12744557. |
2. El-Zoghby ZM, Regner KR, Regner DM, Haugen EN. Obstructive Renal Failure from Malpositioned Urinary Catheter. Kidney Int 2008; 73:1330. PMID: 18480860. |
3. Roman RJ, Akbulut T, Park F, Regner KR. 20-HETE in Acute Kidney Injury. Kidney Int. 2011;79:10-13. PMID: 21157458. |
4. Regner KR. Dual role of microsomal prostaglandin E synthase 1 in chronic kidney disease. Hypertension. 2012 Jan;59(1):12-3. |
5. Regner KR. Patients with Hepatorenal Syndrome Should Be Dialyzed? COMMENTARY. Kidney360. 2021 Mar 25;2(3):413-414. PMCID: PMC8786001 |
Abstracts |
1. Moulder JE, Fish BL, Regner KR, Cohen EP, Raife TJ. The growth promoter All-trans retinoic acid (ATRA) exacerbates experimental radiation nephropathy. Presented at the Forty-seventh Annual Meeting of the Radiation Research Society, April 29-May 3, 2000; Albuquerque, New Mexico, USA. |
2. Regner, KR, Connolly, HM, Schaff, HV, Albright, RC. Acute renal failure after cardiac surgery for carcinoid heart disease: Incidence, risk factors, and prognosis. Presented at the 36th Annual Meeting & Scientific Exposition of the American Society of Nephrology, November 14-17, 2003; San Diego, California, USA. |
3. Regner, KR, McGoon, MD, Frantz, RP, Haugen, EN. Chronic kidney disease is associated with pulmonary hypertension and right heart dysfunction. Presented at the National Kidney Foundation Clinical Meeting, April 19-23, 2006; Chicago, IL, USA. |
4. Regner, KR, Grande, JP, Roberts, L, Platt, JL, Haugen, EN. Digestion of heparan sulfate from renal tubular epithelium in human acute tubular necrosis. Presented at the American Society of Nephrology annual meeting, November 15-19, 2006; San Diego, CA, USA. |
5. Dall A, Regner KR, Hussain S. Outcome of severe acute renal failure - a Veterans Affairs Study. Presented at the 13th International Conference on Continuous Renal Replacement Therapies. February 27- March 1, 2008; San Diego, CA, USA |
6. El-Zoghby, Z, Regner KR, Keegan, M, Casey, E. Factitious hyperphosphatemia due to sample contamination with heparin in an arterial line. Presented at the National Kidney Foundation Clinical Meeting, April 2-6, 2008; Dallas, TX, USA. |
7. Haque A, Dall A, Hussain S, Regner, KR. Survival of elderly patients with acute kidney injury requiring continuous renal replacement therapy. Presented at the National Kidney Foundation 2008 Spring Clinical Meeting, April 2-6, 2008, Dallas, Texas, USA. |
8. Regner KR, Zuk A, Shames BD, Van Why SK, Falck JR, Roman RJ. The 20-HETE analogue, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, mitigates experimental renal ischemia-reperfusion injury and prevents the post-ischemic fall in medullary blood flow. J Am Soc Nephrol 2008; 19:400A. |
9. Haque A, Dall A, Marwaha A, Hussain S, Regner KR. Patient survival and renal outcomes in elderly patients with acute kidney injury requiring continuous renal replacement therapy. J Am Soc Nephrol 2008; 19:797A. |
10. Deshmukh A, Kleinman J, Blumenthal S, Regner KR, Hussain S. Treatment of Membranous Nephropathy with Rituximab. J Am Soc Nephrol 2008; 19:970A. |
11. Marwaha A, Regner KR, Dall A, Haque A, Piering W, Hussain S. Epidemiology and Demographics of Biopsy-Proven Acute Interstitial Nephritis. J Am Soc Nephrol 2008; 19:988A. |
12. Akbulut T, Regner KR, Roman RJ, Park F. Effects of 20-HETE analogues on intracellular signaling cascades in renal proximal tubular cells. FASEB J. 2009 23:816.5. |
13. Akbulut T, Roman RJ, Park F, Regner KR. Effect of 20-HETE analogues on renal proximal tubular cell survival following experimental ischemia-reperfusion injury. J Am Soc Nephrol 2009; 20:323A. |
14. Regner KR, Nilakantan V, Mortenson J, White SM, Roman RJ. Lifor preservation solution mitigates experimental renal-ischemia reperfusion injury. J Am Soc Nephrol 2009; 20:337A. |
15. Regner KR, Stelloh C, Eisenhauer J, Lenz MA, Garrett MR. An accelerated model of chronic kidney disease by genetic modification of the Dahl salt-sensitive rat. J Am Soc Nephrol 2009; 20:68A. |
16. Raman L, Regner KR, Blumenthal S. Long Term Follow Up of Loss of Renal Function after an Episode of Acute Kidney Injury. J Am Soc Nephrol 2009; 20:114A. |
17. Solberg-Woods L, Stelloh C, Regner KR, Schwabe T, Eisenhauer J, Garrett MR. Heterogenous stock rats - a new animal model to study the genetics of renal injury. Presented at the 7th Annual Meeting on Rat Genomics & Models. Cold Spring Harbor, New York, 2009. |
18. Saleh M, Herrmann D, Regner KR. Importance of phenytoin monitoring and dose adjustment while on Continuous Veno-Venous Hemofiltration. Continuous Renal Replacement Therapy 2010 meeting, San Diego, CA, USA, Feb 2010. |
19. Regner KR, Akbulut T, Park F, Roman RJ. 20-HETE mitigates experimental ischemia-reperfusion injury. J Invest Med 2010;58:670. |
20. Marthaler B, White SM, Van Why SK, Garrett MR, Roman RJ, Regner KR. Increased Renal CYP4A Expression and 20-HETE Production Promotes Resistance to Renal Ischemia-reperfusion Injury in Rats. Presented at the American Society of Nephrology Meeting 2010. |
21. Kampa N, Solberg-Woods L, Regner KR, Stelloh C, Garrett MR. A Novel Rat Model with >75% of Offspring Exhibiting Spontaneous Unilateral Renal Agenesis. Presented at the American Society of Nephrology Meeting 2010. |
22. Regner KR, Kwon M, White S, Jia G, Nilakantan V, Park F. Activator of G protein signaling 3 promotes renal epithelial cell proliferation following ischemia-reperfusion injury. Presented at the American Society of Nephrology Meeting 2010. |
23. Regner KR, Eisenhauer J, Stelloh C, Mattson DL, Cowley Jr AW, Garrett MR. Knockout of Nuclear Receptor 4a1 on a Hypertensive Genetic Background Results in Severe Renal Injury. Presented at the American Society of Nephrology Meeting 2010. |
24. Williams JM, Stelloh C, Regner KR, Roman RJ, Garrett MR. Genetic Variants in Arhgef11 linked to Proteinuria, Renal Hemodynamic Parameters and GFR in the Dahl Salt-Sensitive Rat. Presented at the American Society of Nephrology Meeting 2010. |
25. Haines EC, White SM, Park F, Regner KR. Gβγ Signaling Plays a Critical Role in Recovery from Renal Ischemia-Reperfusion Injury in Rats. . J Am Soc Nephrol 2012;23:113A. |
