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CURRICULUM VITAE

Kirkwood A. Pritchard PhD
Professor
Department of Surgery
Division of Pediatric Surgery

OFFICE ADDRESS:
Children's Research Institute
9000 W Wisconsin Ave
Milwaukee, WI 53226

EDUCATION:
1975 B.A., Capital University, Columbus, OH
1978 M.S., Youngstown State University, Youngstown, OH
1983 Ph.D., The Ohio State University, Columbus, OH

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
1983 - 1985 Research Fellow, Department of Medicine, Division of Atherosclerosis, Albert Einstein College of Medicine, Bronx, NY
2005 - 2006 UWM/MCW Faculty Leadership Program

FACULTY APPOINTMENTS:
1976 - 1978 Assistant Instructor, Department of Chemistry, Youngstown State University, Youngstown, OH
1983 - 1985 Research Fellow, Albert Einstein College of Medicine, Bronx, NY
1985 - 1987 1985-87 Instructor, Department of Medicine, New York Medical College, Valhalla, NY
1987 Assistant Professor of Medicine, New York Medical College, Valhalla, NY
1988 Assistant Professor of Physiology, New York Medical College, Valhalla, NY
1991 - 1993 1991-1993 Assistant Professor of Experimental Pathology, New York Medical College, Valhalla, NY
1993 - 06/1994 Associate Professor of Experimental Pathology, New York Medical College, Valhalla, NY
07/1994 - 06/2000 Associate Professor of Pathology and Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI
1994 - 2000 Associate Professor, Department of Pathology, Medical College of Wisconsin, Milwaukee, WI
07/2000 - 06/2004 Associate Professor of Surgery, Division of Pediatric Surgery and Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI
07/2004 - 06/2005 Professor of Surgery, Division of Pediatric Surgery and Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI
07/2005 - Present Professor of Surgery with Tenure, Division of Pediatric Surgery and Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI
02/2006 - Present Vice-Chair of Research for Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI
07/2007 - Present Director of Translational Vascular Biology Program for Children’s Research Institute, Department of Pediatric Surgery, Medical College of Wisconsin, Milwaukee, WI
09/2008 - 06/2010 Chair of Research Affairs Committee, Office of Research, Medical College of Wisconsin, Milwaukee, WI

ADMINISTRATIVE APPOINTMENTS:
2003 - 2005 Associate Director, Inflammation Club Work-In-Progress and Journal Club Seminar Series
2003 - Present Associate Director, Cardiovascular Center Work-In-Progress Seminar Series
2005 - Present Co-director, Pediatric Surgery Multidisciplinary Research Conference
2006 - Present Vice-Chair, Research for Surgery
2007 - Present Director, Translational Vascular Biology Program

HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS:
07/1994 - 06/1995 Associate Director of Clinical Biochemistry, Department of Pathology, United Regional Medical Services, Froedert Memorial Lutheran Hospital
07/1995 - 02/1999 Director of Clinical Biochemistry, Department of Pathology, United/Dynacare Laboratories, Froedtert Memorial Lutheran Hospital

RESEARCH ADMINISTRATIVE APPOINTMENTS:
1985 - 1991 Technical Director & Manager, Department of Medicine, Lipid Laboratory of the Atherosclerosis Research Unit, New York Medical College
1996 - 2007 Co-Director of Adenoviral Core Laboratory, Cardiovascular Research Center, Medical College of Wisconsin
2007 - Present Director of Translational Vascular Biology Program, Department of Surgery / Children’s Research Institute, Medical College of Wisconsin, Milwaukee, WI

SPECIALTY BOARDS AND CERTIFICATION:
Board Certified
Issue DateExpiration
American Board of Clinical Chemistry
1999
1999
 
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
1996 - 1999 National American Heart Association Vascular Biology II
11/1998 VA Merit Awards
03/1999 NIH BBCB (Ad hoc Reviewer)
04/1999 NIEHS HBCU Inter-Institutional Programs Dr. Galvin
06/1999 NIH/CSR/BCS/SSS-2 SRA Dr. H Khan
11/2001 - 2004 NIH NHLBI PATH A (Ad hoc Reviewer)
06/2004 NIH NHLBI Atherosclerosis and Inflammation of the Cardiovascular System (AICS) (Ad hoc Reviewer)
09/2004 NHLBI PPO Study section
06/2005 - Present NIH NHLBI AICS (Member)
10/2007 - 06/2009 NIH NHLBI (Chairman of AICS )
American Society for Biochemistry and Molecular Biology (ASBMB, applied/pending)
National American Heart Association Shock Society
American Physiological Society (APS)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorial Board
American Journal of Physiology: Heart and Circulation
Journal Review
Circulation Research
Vascular Biology
Thrombosis & Vascular Biology
Free Radicals in Biology and Medicine
Hypertension
Arteriosclerosis
Journal of Biological Chemistry
Circulation
Nitric Oxide
Journal of Pharmacology and Experimental Therapeutics
Biochemical Journal
Proceedings of the National Academy of Science
American Journal of Pathology

LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
2007 - 06/2010 Research Affairs Committee

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Novel Peptide MPO Inhibitors for Treating Atherosclerosis
Source:
NIH/NHLBI
Role:
Principal Investigator
Dates:
01/01/2011 - 12/31/2013
Direct Funds:
$150,000 (first year)
 
Title:
Biophysics of HDL Dysfunction
Source:
NIH/NHLBI
Role:
Principle Investigator
Dates:
07/01/2012 - 06/30/2016
Direct Funds:
$424,130 (first year)
 
Title:
Development of Novel Bioassays for Assessing Receptor for Advanced Glycosylated End-Product Activity in Children and Adolescents with Sickle Cell Disease
Source:
Children’s Research Institute
Role:
Principle Investigator
Dates:
01/01/2015 - 12/31/2015
Direct Funds:
$50,000
 
Non-Peer Review
Title:
lnflammation, Fibrosis and Myocardial Function in SSc
Source:
NHLBI RO1 HL089779-01A1
Role:
Consultant
Dates:
04/01/2008 - 03/30/2013
Direct Funds:
$250,000
 
Title:
Regulation of Pulmonary Circulation in Fetus and Newborns
Source:
NHLBI
Role:
Co-Investigator
Dates:
04/01/2010 - 03/31/2014
Direct Funds:
$179,977 (first year)
 
Title:
Asthma Increases Vaso-occlusion in Sickle Cell Disease
Source:
NHLBI
Role:
Co-Principal Investigator
Dates:
09/01/2010 - 08/31/2014
Direct Funds:
$455,483 (first year)
 
Title:
Reduction of Vibration Induced Fatigue or Injuries by Pre-Conditioning with D-4F
Source:
DOD
Role:
Co-Investigator
Dates:
05/01/2011 - 04/30/2014
Direct Funds:
$157,222
 
Pending
Non-Peer Review
Title:
Biolayer Interferometry and In Vitro Measures of HDL Function
Source:
NIH/NHLBI
Role:
Principle Investigator
Dates:
10/01/2011 - 09/30/2013
Direct Funds:
$150,000 (first year)
 
Prior
Non-Peer Review
Title:
Mechanisms of Native LDL-induced EC Dysfunction
Source:
NHLBI HL-48251 (05)
Role:
Principal Investigator
Dates:
02/01/1993 - 01/31/1997
Direct Funds:
$145,000 (first year)
 
Title:
Nitric Oxide and Tolerance of Hypoxic Heart to Ischemia
Source:
NHLBI
Role:
Consultant
Dates:
04/01/1997 - 03/31/2002
Direct Funds:
$126,738 (first year)
 
Title:
Gastrointestinal Motor Effects of Ionizing Radiation
Source:
NIH
Role:
Consultant
Dates:
07/01/1997 - 06/30/2001
Direct Funds:
$102,645 (first year)
 
Title:
Mechanisms of Dichromate Activation of Endothelial Cells
Source:
NIEHS (R03-ES-09349-01)
Role:
Principal Investigator
Dates:
01/01/1998 - 12/31/1999
Direct Funds:
$50,000
 
Title:
Superoxide Generation from Endothelial NOS, An ESR Investigation
Source:
WI American Heart Association
Role:
Co-Sponsor
Dates:
01/01/1998 - 12/31/1999
 
Title:
eNOS and Radical Mechanisms of Antitumor Anthracyclins
Source:
NIH/NCI R01-CA-77822-01A1
Role:
Co-Investigator
Dates:
01/01/1999 - 01/01/2001
Direct Funds:
$131,633 (first year)
 
Title:
Native LDL, Cholesterol and Impaired Vasorelaxation
Source:
NHLBI R01
Role:
Principal Investigator
Dates:
06/05/1999 - 05/31/2003
Direct Funds:
$148,000 (first year)
 
Title:
Gene Expression in Children with Congenital Cardiac Defects
Source:
Children’s Hospital of Wisconsin Foundation
Role:
Co-Investigator
Dates:
02/01/2000 - 01/31/2002
 
Title:
Chronic Hypoxia and Resistance to Myocardial Ischemia
Source:
NHLBI
Role:
Co-investigator
Dates:
04/01/2001 - 03/31/2006
Direct Funds:
$250,000 (first year)
 
Title:
Vascular Signaling by Free Radicals, Project #1 Modification of Vascular Signaling in the Brain by ROS
Source:
NHLBI
Role:
Co-investigator
Dates:
07/01/2002 - 06/30/2007
Direct Funds:
$1,100,000 (first year)
 
Title:
Nitric Oxide Regulation of Steriodogenesis
Source:
NHLBI
Role:
Co-investigator
Dates:
07/01/2002 - 06/30/2005
Direct Funds:
$175,000
 
Title:
Hsp90 Mediates eNOS and Vascular Function
Source:
NHLBI
Role:
Principal Investigator
Dates:
07/01/2002 - 06/30/2006
Direct Funds:
$200,000 (first year)
 
Title:
Native LDL, Cholesterol and Impaired Vasodilation
Source:
NHLBI R01
Role:
Principal Investigator
Dates:
07/01/2003 - 06/20/2008
Direct Funds:
$250,000 (first year)
 
Title:
Regulation of Pulmonary Circulation in Fetus and Newborn
Source:
NHLBI
Role:
Co-investigator
Dates:
07/01/2003 - 06/30/2007
Direct Funds:
$125,000 (first year)
 
Title:
CRP in Atherosclerosis
Source:
NIH Subcontract with Ishwarlal (Kenny) Jialal MD, PhD. at UC Davis
Role:
Co-investigator on grant, Principal Investigator of subcontract
Dates:
2004 - 2006
Direct Funds:
$32,000 (first year)
 
Title:
Asthma and Nocturnal Hypoxemia in Sickle Cell Anemia
Source:
Subcontract of NIH RFA to Michael DeBaun, M.D. Washington University, St. Louis, MO
Role:
Co-Investigator in RFA, PI for the Milwaukee Site
Dates:
2005 - 2009
Direct Funds:
$240,000 (first year)
 
Title:
HDL Dysfunction and Vascular Inflammation
Source:
NHLBI RO1 HL081139A
Role:
Principal Investigator
Dates:
04/01/2006 - 03/30/2011
Direct Funds:
$250,000
 
Title:
Angiostatic Factors and Impaired Angiogenesis In SSc
Source:
Scleroderma Research Foundation
Role:
Principal Investigator
Dates:
2006
Direct Funds:
$55,000 (seed grant)
 
Title:
Role of Microfibril and Connective Tissue Function in Endothelial Mesenchymal Transition
Source:
MCW Clinical and Translation Science Institute
Role:
Co-investigator
Dates:
04/01/2009 - 09/30/2010
Direct Funds:
$40,000
 
Title:
Novel Peptide MPO Inhibitors for Treating Atherosclerosis
Source:
NIH/NHLBI
Role:
Principal Investigator
Dates:
01/01/2010 - 12/31/2011
Direct Funds:
$150,000 (firat year)
 
Title:
The Role of Myeloperoxidase in SLE Induced Atheroslerosis
Source:
MCW Clinical and Translation Science Institute
Role:
Principal Investigator
Dates:
01/01/2010 - 12/31/2010
Direct Funds:
$25,000
 
Title:
The Genetic Basis for Phenotypic Changes in Clinical Biochemistry, Hematology and Histology in Rats
Source:
NIH/NHLBI PGA U01 HL 0066579-01
Role:
Project leader
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
What does sickle cell disease have in common with hypercholesterolemia?, Research Conference, Medical College of Wisconsin, Department of Surgery, 04/07/2004
Matrix Instability and Impaired Angiogenesis in Tight Skin Mice - A Murine Model for Systemic Sclerosis, Guest Speaker, MCW, Department of Physiology, 02/28/2007
Advances in the Development of Novel Anti-Inflammatory Inhibitors, 2011 Pulmonary and Critical Care Research Retreat, 05/10/2011
Oh eNOS, I thought I knew You, Department of Physiology, Medical College of Wisconsin
 
National
Chairmen, K.A. Pritchard, Jr., Ph.D, D. G. Harrison, M.D., n-LDL, Cholesterol and eNOS Dysfunction, Experimental Biology 2000, eNOS Dysfunction and Vascular Disease I and II (Full Day Scientific Session), San Diego, CA, 04/15/2000 - 04/18/2000
Chairman V. Vallyathan, Ph.D. (NIOSH), Chromium(VI) increases endothelial cell inflammation by inhibiting nitric oxide activity, Molecular Mechanisms of Metal Toxicity and Carcinogenesis, co-sponsored by OSHA and NIOSH, Morgantown, WV, 09/10/2000 - 09/12/2000
Hot Topics: Heat Shock Protein 90 (Hsp90) Mediates Endothelial Nitric Oxide Synthase (eNOS) Superoxide Anion Generation, Gordon Research Conference on NO, 02/2001
Hsp90 Mediates eNOS Function, University of California Los Angeles, Department of Medicine, Cardiology, 10/2002
Hot Topics: L-4F, an apo A-1 mimetic, dramatically improves vasodilation in hypercholesterolemia and sickle cell disease, Gordon Research Conference on NO, 02/2003
Hsp90 Interactions with eNOS, Medical College of Georgia, Department of Pharmacology & Toxicology and Cardiovascular Research Center, 02/2003
eNOS Dysfunction in Hypercholesterolemia and Sickle Cell Disease: A Common Theme Between Two Dissimilar Genetic Diseases, Whitaker Cardiovascular Research Institute, Boston University, 03/09/2004
Endothelial Cell Dysfunction in Hypercholesterolemia and Sickle Cell Disease: A Common Theme Between Two Dissimilar Genetic Diseases, University of Alabama, Birmingham, 03/19/2004
The role of EC and eNOS-dysfunction in hypercholesterolemia and sickle cell disease, Department of Pediatrics, Washington University, St. Louis, MO, 04/21/2004
Asthma and Nocturnal Hypoxemia (Basic Science – Murine Models of Sickle Cell Anemia for Studying Pathogenesis of Asthma and Nocturnal Hypoxemia on Pulmonary Disease), Annual Sickle Cell Disease Clinical Research Meetings, The Natcher Conference Center, NIH Campus Building 45, 45 Center Drive, Bethesda, MD, 08/29/2005 - 09/02/2005
Matrix Instability and Impaired Angiogenesis in Tight Skin Mice - A Murine Model for Systemic Sclerosis, Guest Speaker for Dr. Fogelman’s PPG, UCLA, Department of Medicine, 10/07/2007
The role of HDL and 4F, an apoA-I mimetic, in Sickle Cell Disease, Vascular Medicine Branch, Building 10, NIH Campus, Bethesda, MD, 10/10/2007
Native LDL induces EC Dysfunction, New York Medical College, Department of Physiology
Mechanisms of eNOS Uncoupling, University of California, Riverside, Department of Biomedical Sciences
 
International
Chairman and Speaker, eNOS Dysfunction and Vascular Disease, FASEB 2000, San Diego, 04/2000
Invited Speaker, Angiostatin, a Negative Regulator of Vasodilation, Satellite Symposium at the International Meeting on Hypertension, Prague, CZ, 07/2002
Hot Topics: Angiostatin, Uncouples eNOS Activity, Second International Conference on NO, 07/2002
Chairman, Vascular Responses, FASEB 2003, San Diego, CA, 04/2003
Invited Speaker, Hsp90 eNOS Interactions, American Heart Association 2003, 11/2003
Effects of D-4F, an apo A-I mimetic on inflammation and fibrosis in the myocardium of tight skin mice, 9th International Workshop on Scleroderma Research, Boston Massachusetts, 08/05/2006 - 08/09/2006
Invited Speaker, Plenary Session Chairman, Novel Myleoperoxidase Inhibitors Inhibit LDL Oxidation and Improve Vasodilatation, International Academy of Cardiology, 15th World Congress on Heart Disease, Vancouver, 07/2010
 

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Postdoctoral Students
Yang Shi, Ph.D., Medical College of Wisconsin
Jingsong Ou, M.D., Ph.D., Medical College of Wisconsin
Jeannette Vasquez-Vivar, Ph.D., Medical College of Wisconsin
David Klick, Medical College of Wisconsin
Zhijun Ou, M.D., Medical College of Wisconsin
 
Residents
Deborah Nowak, M.D., Medical College of Wisconsin
Paul Signorino, M.D., Medical College of Wisconsin
Denise Klinker, M.D., Medical College of Wisconsin
 
Faculty
Hao Xu, Ph.D., Medical College of Wisconsin
John Densmore, M.D., Medical College of Wisconsin
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
Graduate Students
PhD Students Advised
Na Wei, Pre-doctoral Training Program with Shandong University (Jinan, China), 09/2007 Molecular Mechanisms in Cardioprotection
Weiling Wang, Pre-doctoral Training Program with Shandong University (Jinan, China), 09/2007 Inflammation and Airway Mechanics in Asthma
 
Postdoctoral Students
Scott Welak, SPUR program student, Medical School, 09/2002
Tracey Geiger, SPUR program student, Medical School, 09/2003
David M. Smalley, Ph.D., Univ. of Kansas Med. Center, Kansas City, KS
Alex B. Fair, MS, Medical software company, New York, New York
Jane Lin, Ph.D., New York Medical College
Horace Lo, M.D., USAF General Surgeon, Biloxi, MI
 

MAJOR RESEARCH INTERESTS:
Endothelial and cardiac cell biology
Molecular mechanisms of free radical generation
Inflammation in hypercholesterolemia, sickle cell disease, scleroderma and asthma
Adenoviral Gene Transfer Technology
Nitric oxide and superoxide anion balance
Cellular biology of endothelial nitric oxide synthase


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Cheng J, Ou JS, Singh H, Falck JR, Narsimhaswamy D, Pritchard KA, Jr., Schwartzman ML. 20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling. Am J Physiol Heart Circ Physiol. 2008;294:H1018-1026
2. Pritchard Jr., KA. Surfactant D protein - not for the lung anymore. Am J Physiol Heart Circ Physiol. 2008;294(5):H1994
3. Sander TL, Ou JS, Densmore JC, Kaul S, Matus I, Twigger S, Halligan B, Greene AS, Pritchard Jr. KA, Oldham KT. Protein composition of plasminogen activator inhibitor type 1-derived endothelial microparticles. Shock 2008; 29(4):504-511
4. Peterson DB, Sander T, Kaul S, Wakim BT, Halligan B, Twigger S, Pritchard Jr. KA, Oldham KT, Ou JS. Comparative proteomic analysis of PAI-1 and TNF-alpha-derived endothelial microparticles. Proteomics June 2008;8(12):2430-46
5. Frei AC, Guo Y, Jones DW, Pritchard Jr., KA, Fagan KA, Hogg N, Wandersee NJ. Vascular dysfunction in a murine model of severe hemolysis. Blood July 2008;112(2):398-405
6. Xu H, Pritchard Jr., KA. Targeted Increases in Endothelial Cell Superoxide Anion Production Stimulate eNOS-dependent Nitric Oxide Production, Not Uncoupled eNOS Activity. Arteriscler Thromb Vasc Biol. 2008;28:1580-1581
7. Nandedkar SD, Feroah TR, Hutchins W, Weihrauch D, Konduri KS, Wang J, Strunk RC, DeBaun MR, Hillery CA, Pritchard Jr., KA. Histopathology of experimentally-induced asthma in a murine model of sickle cell disease. Blood 2008;112(6):2529-38
8. Larsen BT, Bubolz AH, Mendoza SA, Pritchard Jr., KA, Gutterman DD. Bradykinin-induced dilation of human coronary arterioles requires NADPH oxidase-derived reactive oxygen species. Arterioscler Thromb Vasc Biol 2009;29:739-745
9. Du J, Xu H, Wei N, Wakim B, Halligan B, Pritchard Jr., KA, Shi Y. Identification of proteins interacting with GTP cyclohydrase I. Biochem Biophys Res Commun 2009;385(2):143-147
10. Du J, Wei N, Guan T, Xu H, An J, Pritchard Jr. KA, and Shi Y. Inhibition of CDKs by roscovitine suppressed LPS-induced •NO production through inhibiting NFkB activation and BH4 biosynthesis in macrophages. Am J Physiol Cell Physiol 2009; 297(3):C742-C749 PMCID: 2740392
11. An J, Du J, Wei N, Xu H, Pritchard Jr., KA, Shi Y. Role of tetrahydrobiopterin in resistance to myocardial ischemia in Brown Norway and Dahl S rats. Am J Physiol Heart Circ Physiol 2009; 297(5):H1783-H1791 PMCID in process
12. Du J, Wei N, Xu H, Vasquez-Vivar J, Oldham KT, Pritchard Jr., KA, Shi Y. Identification and functional characterization of phosphorylation sites on GTP Cyclodydrolase I. Arterioscler. Thromb. Vasc. Biol 2009; 29:2161-2168 PMCID in process
13. Du J, An J, Wei N, Guan T, Pritchard Jr., KA, Shi Y. Increased resistance to LPS-induced myocardial dysfunction in the Brown Norway rats versus Dahl S rats: roles of inflammatory cytokines and nuclear factor kappaB pathway. Shock 2010 March; 33(3):332-6 PMCID in process
14. Whitehouse JS, Xu H, Shi Y, Noll L, Kaul S. Jones DW, Pritchard Jr., KA, Oldham KT, Gourlay DM. Mesenteric nitric oxide and superoxide production in experimental necrotizing enterocolitis. Journal of Surgical Research 2010 Jun 1;161(1):1-8 PMCID in process
15. Wang W, Xu H, Shi Y, Nandedkar S, Zhang H, Gao H, Feroah T, Weihrauch D, Schulte ML, Jones DW, Jarzembowski J, Sorci-Thomas M, Pritchard Jr., KA. Genetic deletion of apolipoprotein A-I increases airway hyperresponsiveness, inflammation, and collagen deposition in the lung. J Lipid Res 2010 Sep;51(9):2560-70. PMCID in process
16. Rowe DJ, Yan J, Zhang L, Pritchard Jr., KA, Kao DS, Matloub HS, Riley DA. The preventative effects of apolipoprotein mimetic D-4F from vibration injury - experiment in rats. Hand Surgery 2010; Epub ahead of print
17. Whitehouse JS, Riggle KM, Purpi DP, Mayer AN, Pritchard Jr., KA, Oldham KT, Gourlay DM. The protective role of intestinal alkaline phosphotase in necrotizing enterocolitis. J Surg Res. 2010 Sep;163(1):79-85.
18. Teng RJ, Wu TJ, Bisig CG, Eis A, Pritchard Jr., KA, Konduri GG. Nitrotyrosine impairs angiogenesis and uncouples eNOS activity of pulmonary artery endothelial cells isolated from developing sheep lungs. Pediatr Res. 2011 Feb; 69(2):112-7
19. Buesing KL, Densmore JC, Kaul S, Pritchard Jr., KA, Jarzembowski JA, Gourlay DM, Oldham KT. Endothelial microparticles induce inflammation in acute lung injury. J Surg Res. 2011 Mar; 166(1):32-9
20. Xu H, Zaidi M, Struve J, Jones DW, Krolikowski J, Lohr N, Pagel P, Csuka ME, Pritchard Jr., KA, Weihrauch D. Abnormal fibrillin-1 expression and chronic oxidative stress mediate endothelial mesenchymal transition in a murine model of systemic sclerosis. Am J Physiol Cell Physiol 2011 Mar; 300(3):C550-6
21. Zaidi M, Krolikowski JG, Jones DW, Pritchard Jr., KA, Struve J, Nandedkar SD, Lohr NL, Pagel PS, Weihrauch D. Transient repetitive exposure to low level light therapy enhances collateral blood vessel growth in the ischemic hindlimb of the tight skin mouse. Photochem Photobiol. May 2013:89(3):709-13 PMCID: PMC3597754
22. Densmore JC, Jeziorczak PM, Clough AV, Pritchard KA Jr, Cummens B, Medhora M, Rao A, Jacobs ER. Rattus model utilizing selective pulmonary ischemia induces bronchiolitis obliterans organizing pneumonia. Shock. 2013 Mar;39(3):271-7. PMCID: PMC3578046
23. Xu H, Krolikowski JG, Jones DW, Ge ZD, Pagel PS, Pritchard KA Jr, Weihrauch D. 4F decreases IRF5 expression and activation in hearts of tight skin mice. PLoS One. 2012;7(12):e52046. PMCID: PMC3522636
24. Zaidi M, Krolikowki JG, Jones DW, Pritchard KA Jr, Struve J, Nandedkar SD, Lohr NL, Pagel PS, Weihrauch D. Transient repetitive exposure to low level light therapy enhances collateral blood vessel growth in the ischemic hindlimb of the tight skin mouse. Photochem Photobiol. 2013 May-Jun;89(3):709-13. PMCID: PMC3597754
25. Rentea RM, Welak SR, Fredrich K, Donohoe D, Pritchard KA, Oldham KT, Gourlay DM, Liedel JL. Early enteral stressors in newborns increase inflammatory cytokine expression in a neonatal necrotizing enterocolitis rat model. Eur J Pediatr Surg. 2013 Feb;23(1):39-47. PMCID: PMC5664148
26. Riggle KM, Rentea RM, Welak SR, Pritchard KA Jr, Oldham KT, Gourlay DM. Intestinal alkaline phosphatase prevents the systemic inflammatory response associated with necrotizing enterocolitis. J Surg Res. 2013 Mar;180(1):21-6. PMCID: PMC5664146
27. Hanson MS, Xu H, Flewelen TC, Holzhauer SL, Retherford D, Jones DW, Frei AC, Pritchard KA Jr, Hillery CA, Hogg N, Wandersee NJ. A novel hemoglobin-binding peptide reduces cell-free hemoglobin in murine hemolytic anemia. Am J Physiol Heart Circ Physiol. 2013 Jan 15;304(2):H328-36. PMCID: PMC3543667
28. Rentea RM, Liedel JL, Welak SR, Cassidy LD, Mayer AN, Pritchard KA Jr, Oldham KT, Gourlay DM. Intestinal alkaline phosphatase administration in newborns is protective of gut barrier function in a neonatal necrotizing enterocolitis rat model. J Pediatr Surg. 2012 Jun;47(6):1135-42.
29. Rentea RM, Liedel JL, Fredrich K, Welak SR, Pritchard KA Jr, Oldham KT, Simpson PM, Gourlay DM. Intestinal alkaline phosphatase administration in newborns decreases systemic inflammatory cytokine expression in a neonatal necrotizing enterocolitis rat model. J Surg Res. 2012 Oct;177(2):228-34. PMCID: PMC5664150
30. Rowe DJ, Yan JG, Zhang LL, Pritchard KA Jr, Kao DS, Matloub HS, Riley DA. The preventive effects of apolipoprotein mimetic D-4F from vibration injury-experiment in rats. Hand (N Y). 2011 Mar;6(1):64-70. PMCID: PMC3041892
31. Pritchard KA Jr, Feroah TR, Nandedkar SD, Holzhauer SL, Hutchins W, Schulte ML, Strunk RC, Debaun MR, Hillery CA. Effects of experimental asthma on inflammation and lung mechanics in sickle cell mice. Am J Respir Cell Mol Biol. 2012 Mar;46(3):389-96. PMCID: PMC3326430
32. Teng RJ, Du J, Xu H, Bakhutashvili I, Eis A, Shi Y, Pritchard KA Jr, Konduri GG. Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase. Am J Physiol Lung Cell Mol Physiol. 2011 Sep;301(3):L334-45. PMCID: PMC3174740
33. Phillips SA, Das E, Wang J, Pritchard K, Gutterman DD. Resistance and aerobic exercise protects against acute endothelial impairment induced by a single exposure to hypertension during exertion. J Appl Physiol (1985). 2011 Apr;110(4):1013-20. PMCID: PMC3075126
34. Xu H, Zaidi M, Struve J, Jones DW, Krolikowski JG, Nandedkar S, Lohr NL, Gadicherla A, Pagel PS, Csuka ME, Pritchard KA, Weihrauch D. Abnormal fibrillin-1 expression and chronic oxidative stress mediate endothelial mesenchymal transition in a murine model of systemic sclerosis. Am J Physiol Cell Physiol. 2011 Mar;300(3):C550-6. PMCID: PMC3063974
35. Nandedkar SD, Weihrauch D, Xu H, Shi Y, Feroah T, Hutchins W, Rickaby DA, Duzgunes N, Hillery CA, Konduri KS, Pritchard KA Jr. D-4F, an apoA-1 mimetic, decreases airway hyperresponsiveness, inflammation, and oxidative stress in a murine model of asthma. J Lipid Res. 2011 Mar;52(3):499-508. PMCID: PMC3035686
36. Teng RJ, Wu TJ, Bisig CG, Eis A, Pritchard KA, Konduri GG. Nitrotyrosine impairs angiogenesis and uncouples eNOS activity of pulmonary artery endothelial cells isolated from developing sheep lungs. Pediatr Res. 2011 Feb;69(2):112-7. PMCID: PMC3086583
37. Buesing KL, Densmore JC, Kaul S, Pritchard KA Jr, Jarzembowski JA, Gourlay DM, Oldham KT. Endothelial microparticles induce inflammation in acute lung injury. J Surg Res. 2011 Mar;166(1):32-9. PMCID: PMC4731030
38. Whitehouse JS, Riggle KM, Purpi DP, Mayer AN, Pritchard KA Jr, Oldham KT, Gourlay DM. The protective role of intestinal alkaline phosphatase in necrotizing enterocolitis. J Surg Res. 2010 Sep;163(1):79-85.
39. Wang W, Xu H, Shi Y, Nandedkar S, Zhang H, Gao H, Feroah T, Weihrauch D, Schulte ML, Jones DW, Jarzembowski J, Sorci-Thomas M, Pritchard KA Jr. Genetic deletion of apolipoprotein A-I increases airway hyperresponsiveness, inflammation, and collagen deposition in the lung. J Lipid Res. 2010 Sep;51(9):2560-70. PMCID: PMC2918439
40. Du J, An J, Wei N, Guan T, Pritchard KA Jr, Shi Y. Increased resistance to LPS-induced myocardial dysfunction in the Brown Norway rats versus Dahl S rats: roles of inflammatory cytokines and nuclear factor kappaB pathway. Shock. 2010 Mar;33(3):332-6. PMCID: PMC3193159
41. Whitehouse JS et al. The protective role of intestinal alkaline phosphatase in necrotizing enterocolitis. J Surg Res. 2010 Feb;158(2):201
42. Whitehouse JS, Xu H, Shi Y, Noll L, Kaul S, Jones DW, Pritchard KA Jr, Oldham KT, Gourlay DM. Mesenteric nitric oxide and superoxide production in experimental necrotizing enterocolitis. J Surg Res. 2010 Jun 01;161(1):1-8. PMCID: PMC3196648
43. Du J, Wei N, Xu H, Ge Y, Vásquez-Vivar J, Guan T, Oldham KT, Pritchard KA Jr, Shi Y. Identification and functional characterization of phosphorylation sites on GTP cyclohydrolase I. Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2161-8. PMCID: PMC2798731
44. An J, Du J, Wei N, Xu H, Pritchard KA Jr, Shi Y. Role of tetrahydrobiopterin in resistance to myocardial ischemia in Brown Norway and Dahl S rats. Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1783-91. PMCID: PMC2781371
45. Du J, Wei N, Guan T, Xu H, An J, Pritchard KA Jr, Shi Y. Inhibition of CDKS by roscovitine suppressed LPS-induced *NO production through inhibiting NFkappaB activation and BH4 biosynthesis in macrophages. Am J Physiol Cell Physiol. 2009 Sep;297(3):C742-9. PMCID: PMC2740392
46. Du J, Xu H, Wei N, Wakim B, Halligan B, Pritchard KA Jr, Shi Y. Identification of proteins interacting with GTP cyclohydrolase I. Biochem Biophys Res Commun. 2009 Jul 24;385(2):143-7. PMCID: PMC2737525
47. Larsen BT, Bubolz AH, Mendoza SA, Pritchard KA Jr, Gutterman DD. Bradykinin-induced dilation of human coronary arterioles requires NADPH oxidase-derived reactive oxygen species. Arterioscler Thromb Vasc Biol. 2009 May;29(5):739-45. PMCID: PMC2727937
48. Xu H, Pritchard KA Jr. Targeted increases in endothelial cell superoxide anion production stimulate eNOS-dependent nitric oxide production, not uncoupled eNOS activity. Arterioscler Thromb Vasc Biol. 2008 Sep;28(9):1580-1.
49. Sander TL, Ou JS, Densmore JC, Kaul S, Matus I, Twigger S, Halligan B, Greene AS, Pritchard KA Jr, Oldham KT. Protein composition of plasminogen activator inhibitor type 1-derived endothelial microparticles. Shock. 2008 Apr;29(4):504-11.
50. Nandedkar SD, Feroah TR, Hutchins W, Weihrauch D, Konduri KS, Wang J, Strunk RC, DeBaun MR, Hillery CA, Pritchard KA. Histopathology of experimentally induced asthma in a murine model of sickle cell disease. Blood. 2008 Sep 15;112(6):2529-38. PMCID: PMC2532817
51. Peterson DB, Sander T, Kaul S, Wakim BT, Halligan B, Twigger S, Pritchard KA Jr, Oldham KT, Ou JS. Comparative proteomic analysis of PAI-1 and TNF-alpha-derived endothelial microparticles. Proteomics. 2008 Jun;8(12):2430-46. PMCID: PMC4753841
52. Frei AC, Guo Y, Jones DW, Pritchard KA Jr, Fagan KA, Hogg N, Wandersee NJ. Vascular dysfunction in a murine model of severe hemolysis. Blood. 2008 Jul 15;112(2):398-405. PMCID: PMC2442749
53. Pritchard KA Jr. Surfactant protein D: not just for the lung anymore. Am J Physiol Heart Circ Physiol. 2008 May;294(5):H1994.
54. Cheng J, Ou JS, Singh H, Falck JR, Narsimhaswamy D, Pritchard KA Jr, Schwartzman ML. 20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling. Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H1018-26.
55. Zhang H, Jing X, Shi Y, Xu H, Du J, Guan T, Weihrauch D, Jones DW, Wang W, Gourlay D, Oldham KT, Hillery CA, Pritchard KA Jr. N-acetyl lysyltyrosylcysteine amide inhibits myeloperoxidase, a novel tripeptide inhibitor. J Lipid Res. 2013 Nov;54(11):3016-29. PMCID: PMC3793606
56. Zhang H, Xu H, Weihrauch D, Jones DW, Jing X, Shi Y, Gourlay D, Oldham KT, Hillery CA, Pritchard KA Jr. Inhibition of myeloperoxidase decreases vascular oxidative stress and increases vasodilatation in sickle cell disease mice. J Lipid Res. 2013 Nov;54(11):3009-15. PMCID: PMC3793605
57. Ji X, Xu H, Zhang H, Hillery CA, Gao HQ, Pritchard KA Jr. Anion exchange HPLC isolation of high-density lipoprotein (HDL) and on-line estimation of proinflammatory HDL. PLoS One. 2014;9(3):e91089. PMCID: PMC3946658
58. Du J, Li Z, Li QZ, Guan T, Yang Q, Xu H, Pritchard KA, Camara AK, Shi Y. Enoyl coenzyme a hydratase domain-containing 2, a potential novel regulator of myocardial ischemia injury. J Am Heart Assoc. 2013 Oct 09;2(5):e000233. PMCID: PMC3835224
59. Xu H, Wandersee NJ, Guo Y, Jones DW, Holzhauer SL, Hanson MS, Machogu E, Brousseau DC, Hogg N, Densmore JC, Kaul S, Hillery CA, Pritchard KA Jr. Sickle cell disease increases high mobility group box 1: a novel mechanism of inflammation. Blood. 2014 Dec 18;124(26):3978-81. PMCID: PMC4271182
60. Heinzerling NP, Liedel JL, Welak SR, Fredrich K, Biesterveld BE, Pritchard KA Jr, Gourlay DM. Intestinal alkaline phosphatase is protective to the preterm rat pup intestine. J Pediatr Surg. 2014 Jun;49(6):954-60; discussion 960. PMCID: PMC4130394
61. Rymaszewski AL, Tate E, Yimbesalu JP, Gelman AE, Jarzembowski JA, Zhang H, Pritchard KA Jr, Vikis HG. The role of neutrophil myeloperoxidase in models of lung tumor development. Cancers (Basel). 2014 May 09;6(2):1111-27. PMCID: PMC4074819
62. Ataga KI, Hinderliter A, Brittain JE, Jones S, Xu H, Cai J, Kim S, Pritchard KA, Hillery CA. Association of pro-inflammatory high-density lipoprotein cholesterol with clinical and laboratory variables in sickle cell disease. Hematology. 2015 Jun;20(5):289-96. PMCID: PMC4223013
63. Xu H, Shi Y, Wang J, Jones D, Weilrauch D, Ying R, Wakim B, Pritchard KA Jr. A heat shock protein 90 binding domain in endothelial nitric-oxide synthase influences enzyme function. J Biol Chem. 2007 Dec 28;282(52):37567-74.
64. Sander TL et al. PROTEIN COMPOSITION OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE 1-DERIVED ENDOTHELIAL MICROPARTICLES. Shock. 2007 Aug 16;Publish Ahead of Print:
65. Weihrauch D, Xu H, Shi Y, Wang J, Brien J, Jones DW, Kaul S, Komorowski RA, Csuka ME, Oldham KT, Pritchard KA. Effects of D-4F on vasodilation, oxidative stress, angiostatin, myocardial inflammation, and angiogenic potential in tight-skin mice. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1432-41.
66. Densmore JC, Signorino PR, Ou J, Hatoum OA, Rowe JJ, Shi Y, Kaul S, Jones DW, Sabina RE, Pritchard KA Jr, Guice KS, Oldham KT. Endothelium-derived microparticles induce endothelial dysfunction and acute lung injury. Shock. 2006 Nov;26(5):464-71.
67. Sander TL, Noll L, Klinkner DB, Weihrauch D, He BJ, Kaul S, Zangwill SD, Tweddell JS, Pritchard KA Jr, Oldham KT. Rosiglitazone antagonizes vascular endothelial growth factor signaling and nuclear factor of activated T cells activation in cardiac valve endothelium. Endothelium. 2006 May-Jun;13(3):181-90.
68. Klinkner DB, Densmore JC, Kaul S, Noll L, Lim HJ, Weihrauch D, Pritchard KA Jr, Oldham KT, Sander TL. Endothelium-derived microparticles inhibit human cardiac valve endothelial cell function. Shock. 2006 Jun;25(6):575-80.
69. Chen Y, Medhora M, Falck JR, Pritchard KA Jr, Jacobs ER. Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2006 Sep;291(3):L378-85.
70. Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA Jr, Roman RJ, Tonellato PJ, Cowley AW Jr. BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. Physiol Genomics. 2006 Apr 13;25(2):303-13.
71. Ou J, Wang J, Xu H, Ou Z, Sorci-Thomas MG, Jones DW, Signorino P, Densmore JC, Kaul S, Oldham KT, Pritchard KA Jr. Effects of D-4F on vasodilation and vessel wall thickness in hypercholesterolemic LDL receptor-null and LDL receptor/apolipoprotein A-I double-knockout mice on Western diet. Circ Res. 2005 Nov 25;97(11):1190-7. PMCID: PMC1480357
72. Pritchard KA Jr, Shi Y, Konduri GG. Tetrahydrobiopterin in pulmonary hypertension: pulmonary hypertension in guanosine triphosphate-cyclohydrolase-deficient mice. Circulation. 2005 Apr 26;111(16):2022-4.
73. Shi Y, Hutchins W, Ogawa H, Chang CC, Pritchard KA Jr, Zhang C, Khampang P, Lazar J, Jacob HJ, Rafiee P, Baker JE. Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90. J Mol Cell Cardiol. 2005 Apr;38(4):625-35.
74. Rafiee P, Shi Y, Su J, Pritchard KA Jr, Tweddell JS, Baker JE. Erythropoietin protects the infant heart against ischemia-reperfusion injury by triggering multiple signaling pathways. Basic Res Cardiol. 2005 May;100(3):187-97.
75. Shi Y, Hutchins WC, Su J, Siker D, Hogg N, Pritchard KA Jr, Keszler A, Tweddell JS, Baker JE. Delayed cardioprotection with isoflurane: role of reactive oxygen and nitrogen. Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H175-84.
76. Gendelman M, Halligan N, Komorowski R, Logan B, Murphy WJ, Blazar BR, Pritchard KA Jr, Drobyski WR. Alpha phenyl-tert-butyl nitrone (PBN) protects syngeneic marrow transplant recipients from the lethal cytokine syndrome occurring after agonistic CD40 antibody administration. Blood. 2005 Jan 01;105(1):428-31.
77. Shi Y, Rafiee P, Su J, Pritchard KA Jr, Tweddell JS, Baker JE. Acute cardioprotective effects of erythropoietin in infant rabbits are mediated by activation of protein kinases and potassium channels. Basic Res Cardiol. 2004 May;99(3):173-82.
78. Ou J, Fontana JT, Ou Z, Jones DW, Ackerman AW, Oldham KT, Yu J, Sessa WC, Pritchard KA Jr. Heat shock protein 90 and tyrosine kinase regulate eNOS NO* generation but not NO* bioactivity. Am J Physiol Heart Circ Physiol. 2004 Feb;286(2):H561-9.
79. Pritchard KA Jr, Ou J, Ou Z, Shi Y, Franciosi JP, Signorino P, Kaul S, Ackland-Berglund C, Witte K, Holzhauer S, Mohandas N, Guice KS, Oldham KT, Hillery CA. Hypoxia-induced acute lung injury in murine models of sickle cell disease. Am J Physiol Lung Cell Mol Physiol. 2004 Apr;286(4):L705-14.
80. Lin MI, Fulton D, Babbitt R, Fleming I, Busse R, Pritchard KA Jr, Sessa WC. Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production. J Biol Chem. 2003 Nov 07;278(45):44719-26.
81. Rafiee P, Shi Y, Pritchard KA Jr, Ogawa H, Eis AL, Komorowski RA, Fitzpatrick CM, Tweddell JS, Litwin SB, Mussatto K, Jaquiss RD, Baker JE. Cellular redistribution of inducible Hsp70 protein in the human and rabbit heart in response to the stress of chronic hypoxia: role of protein kinases,. J Biol Chem. 2003 Oct 31;278(44):43636-44.
82. Ou J, Geiger T, Ou Z, Ackerman AW, Oldham KT, Pritchard KA Jr. AP-4F, antennapedia peptide linked to an amphipathic alpha helical peptide, increases the efficiency of Lipofectamine-mediated gene transfection in endothelial cells. Biochem Biophys Res Commun. 2003 Jun 06;305(3):605-10.
83. Ogawa H, Rafiee P, Heidemann J, Fisher PJ, Johnson NA, Otterson MF, Kalyanaraman B, Pritchard KA Jr, Binion DG. Mechanisms of endotoxin tolerance in human intestinal microvascular endothelial cells. J Immunol. 2003 Jun 15;170(12):5956-64.
84. Ou J, Ou Z, Jones DW, Holzhauer S, Hatoum OA, Ackerman AW, Weihrauch DW, Gutterman DD, Guice K, Oldham KT, Hillery CA, Pritchard KA Jr. L-4F, an apolipoprotein A-1 mimetic, dramatically improves vasodilation in hypercholesterolemia and sickle cell disease. Circulation. 2003 May 13;107(18):2337-41.
85. Konduri GG, Ou J, Shi Y, Pritchard KA Jr. Decreased association of HSP90 impairs endothelial nitric oxide synthase in fetal lambs with persistent pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2003 Jul;285(1):H204-11.
86. Ou J, Ou Z, McCarver DG, Hines RN, Oldham KT, Ackerman AW, Pritchard KA Jr. Trichloroethylene decreases heat shock protein 90 interactions with endothelial nitric oxide synthase: implications for endothelial cell proliferation. Toxicol Sci. 2003 May;73(1):90-7.
87. Ou Z, Ou J, Ackerman AW, Oldham KT, Pritchard KA Jr. L-4F, an apolipoprotein A-1 mimetic, restores nitric oxide and superoxide anion balance in low-density lipoprotein-treated endothelial cells. Circulation. 2003 Mar 25;107(11):1520-4.
88. Koshida R, Ou J, Matsunaga T, Chilian WM, Oldham KT, Ackerman AW, Pritchard KA Jr. Angiostatin: a negative regulator of endothelial-dependent vasodilation. Circulation. 2003 Feb 18;107(6):803-6.
89. Ou J, Ou Z, Ackerman AW, Oldham KT, Pritchard KA Jr. Inhibition of heat shock protein 90 (hsp90) in proliferating endothelial cells uncouples endothelial nitric oxide synthase activity. Free Radic Biol Med. 2003 Jan 15;34(2):269-76.
90. Shi Y, Baker JE, Zhang C, Tweddell JS, Su J, Pritchard KA Jr. Chronic hypoxia increases endothelial nitric oxide synthase generation of nitric oxide by increasing heat shock protein 90 association and serine phosphorylation. Circ Res. 2002 Aug 23;91(4):300-6.
91. Stepp DW, Ou J, Ackerman AW, Welak S, Klick D, Pritchard KA Jr. Native LDL and minimally oxidized LDL differentially regulate superoxide anion in vascular endothelium in situ. Am J Physiol Heart Circ Physiol. 2002 Aug;283(2):H750-9.
92. Rafiee P, Shi Y, Kong X, Pritchard KA Jr, Tweddell JS, Litwin SB, Mussatto K, Jaquiss RD, Su J, Baker JE. Activation of protein kinases in chronically hypoxic infant human and rabbit hearts: role in cardioprotection. Circulation. 2002 Jul 09;106(2):239-45.
93. Pritchard KA, Ackerman AW, Ou J, Curtis M, Smalley DM, Fontana JT, Stemerman MB, Sessa WC. Native low-density lipoprotein induces endothelial nitric oxide synthase dysfunction: role of heat shock protein 90 and caveolin-1. Free Radic Biol Med. 2002 Jul 01;33(1):52-62.
94. Go YM, Boo YC, Park H, Maland MC, Patel R, Pritchard KA Jr, Fujio Y, Walsh K, Darley-Usmar V, Jo H. Protein kinase B/Akt activates c-Jun NH(2)-terminal kinase by increasing NO production in response to shear stress. J Appl Physiol (1985). 2001 Oct;91(4):1574-81.
95. Lo HP, Ackland-Berglund CE, Pritchard KA Jr, Guice KS, Oldham KT. Attenuated expression of inducible nitric oxide synthase in lung microvascular endothelial cells is associated with an increase in ICAM-1 expression. J Pediatr Surg. 2001 Aug;36(8):1136-42.
96. Pritchard KA Jr, Ackerman AW, Gross ER, Stepp DW, Shi Y, Fontana JT, Baker JE, Sessa WC. Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase. J Biol Chem. 2001 May 25;276(21):17621-4.
97. Shi Y, Pritchard KA Jr, Holman P, Rafiee P, Griffith OW, Kalyanaraman B, Baker JE. Chronic myocardial hypoxia increases nitric oxide synthase and decreases caveolin-3. Free Radic Biol Med. 2000 Oct 15;29(8):695-703.
98. Pritchard KA Jr, Ackerman A, Kalyanaraman B. Chromium (VI) increases endothelial cell expression of ICAM-1 and decreases nitric oxide activity. J Environ Pathol Toxicol Oncol. 2000;19(3):251-60.
99. Hanke CJ, O'Brien T, Pritchard KA Jr, Campbell WB. Inhibition of adrenal cell aldosterone synthesis by endogenous nitric oxide release. Hypertension. 2000 Jan;35(1 Pt 2):324-8.
100. Vásquez-Vivar J, Hogg N, Martásek P, Karoui H, Tordo P, Pritchard KA Jr, Kalyanaraman B. Effect of redox-active drugs on superoxide generation from nitric oxide synthases: biological and toxicological implications. Free Radic Res. 1999 Dec;31(6):607-17.
101. Vásquez-Vivar J, Hogg N, Martásek P, Karoui H, Pritchard KA Jr, Kalyanaraman B. Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase. J Biol Chem. 1999 Sep 17;274(38):26736-42.
102. Baker JE, Holman P, Kalyanaraman B, Griffith OW, Pritchard KA Jr. Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production. Ann N Y Acad Sci. 1999 Jun 30;874:236-53.
103. Vásquez-Vivar J, Martásek P, Hogg N, Karoui H, Masters BS, Pritchard KA Jr, Kalyanaraman B. Electron spin resonance spin-trapping detection of superoxide generated by neuronal nitric oxide synthase. Methods Enzymol. 1999;301:169-77.
104. Baker JE, Holman P, Kalyanaraman B, Pritchard KA Jr. Adaptation of hearts to chronic hypoxia increases tolerance to subsequent ischemia by increased nitric oxide production. Adv Exp Med Biol. 1998;454:203-17.
105. Vásquez-Vivar J, Kalyanaraman B, Martásek P, Hogg N, Masters BS, Karoui H, Tordo P, Pritchard KA Jr. Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Proc Natl Acad Sci U S A. 1998 Aug 04;95(16):9220-5. PMCID: PMC21319
106. Smalley DM, Hogg N, Kalyanaraman B, Pritchard KA Jr. Endothelial cells prevent accumulation of lipid hydroperoxides in low-density lipoprotein. Arterioscler Thromb Vasc Biol. 1997 Dec;17(12):3469-74.
107. Vásquez-Vivar J, Martasek P, Hogg N, Masters BS, Pritchard KA Jr, Kalyanaraman B. Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin. Biochemistry. 1997 Sep 23;36(38):11293-7.
108. Rieder MJ, Carmona R, Krieger JE, Pritchard KA Jr, Greene AS. Suppression of angiotensin-converting enzyme expression and activity by shear stress. Circ Res. 1997 Mar;80(3):312-9.
109. Vásquez-Vivar J, Hogg N, Pritchard KA Jr, Martasek P, Kalyanaraman B. Superoxide anion formation from lucigenin: an electron spin resonance spin-trapping study. FEBS Lett. 1997 Feb 17;403(2):127-30.
110. Smalley DM, Lin JH, Curtis ML, Kobari Y, Stemerman MB, Pritchard KA Jr. Native LDL increases endothelial cell adhesiveness by inducing intercellular adhesion molecule-1. Arterioscler Thromb Vasc Biol. 1996 Apr;16(4):585-90.
111. Vlasic N, Medow MS, Schwarz SM, Pritchard KA Jr, Stemerman MB. Lipid fluidity modulates platelet aggregation and agglutination in vitro. Life Sci. 1993;53(13):1053-60.
112. Wu M, Pritchard KA Jr, Kaminski PM, Fayngersh RP, Hintze TH, Wolin MS. Involvement of nitric oxide and nitrosothiols in relaxation of pulmonary arteries to peroxynitrite. Am J Physiol. 1994 May;266(5 Pt 2):H2108-13.
113. Pritchard KA Jr, O'Banion MK, Miano JM, Vlasic N, Bhatia UG, Young DA, Stemerman MB. Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo. J Biol Chem. 1994 Mar 18;269(11):8504-9.
114. Fair A, Pritchard KA Jr. Oxidized low density lipoprotein increases U937 cell 5-lipoxygenase activity: induction of 5-lipoxygenase activating protein. Biochem Biophys Res Commun. 1994 Jun 15;201(2):1014-20.
115. Pritchard KA Jr, Groszek L, Smalley DM, Sessa WC, Wu M, Villalon P, Wolin MS, Stemerman MB. Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. Circ Res. 1995 Sep;77(3):510-8.
116. Karpen CW, Pritchard KA Jr, Merola AJ, Panganamala RV. Alterations of the prostacyclin-thromboxane ratio in streptozotocin induced diabetic rats. Prostaglandins Leukot Med. 1982 Feb;8(2):93-103.
117. Pritchard KA Jr, Karpen CW, Merola AJ, Panganamala RV. Influence of dietary vitamin E on platelet thromboxane A2 and vascular prostacyclin I2 in rabbit. Prostaglandins Leukot Med. 1982 Oct;9(4):373-8.
118. Lott JA, Stephan VA, Pritchard KA Jr. Evaluation of the Coomassie Brilliant Blue G-250 method for urinary protein. Clin Chem. 1983 Nov;29(11):1946-50.
119. Pritchard KA, Greco NJ, Panganamala RV. Effect of dietary vitamin E on the production of platelet 12-hydroxyeicosatetraenoic acid (12-HETE). Thromb Haemost. 1986 Feb 28;55(1):6-7.
120. Pritchard KA Jr, Patel ST, Karpen CW, Newman HA, Panganamala RV. Triglyceride-lowering effect of dietary vitamin E in streptozocin-induced diabetic rats. Increased lipoprotein lipase activity in livers of diabetic rats fed high dietary vitamin E. Diabetes. 1986 Mar;35(3):278-81.
121. Morrel EM, Holland JA, Pritchard KA, Colton CK, Stemerman MB. Endothelial cell perturbation and low-density lipoprotein. Quantitative autoradiography. Ann N Y Acad Sci. 1987;516:412-7.
122. Pritchard KA Jr, Holland JA, Rogers NJ, Crean CC, Britton TE, Onigman P, Stemerman MB. Low-density lipoprotein preparation by combined diafiltration and ultracentrifugation. Anal Biochem. 1988 Oct;174(1):121-7.
123. Holland JA, Pritchard KA, Rogers NJ, Stemerman MB. Perturbation of cultured human endothelial cells by atherogenic levels of low density lipoprotein. Am J Pathol. 1988 Sep;132(3):474-8. PMCID: PMC1880753
124. Itskovitz HD, Flamenbaum W, De Gaetano C, Pritchard KA Jr, Stemerman MB. Effect of lovastatin on serum lipids in patients with nonfamilial primary hypercholesterolemia. Clin Ther. 1989 Nov-Dec;11(6):862-72.
125. Miano JM, Holland JA, Pritchard KA Jr, Rogers NJ, Stemerman MB. Low density lipoprotein-mediated endothelial cell perturbation: effects on endothelial cell eicosanoid metabolism. Adv Prostaglandin Thromboxane Leukot Res. 1989;19:248-54.
126. Ng CF, Lam BK, Pritchard KA Jr, Stemerman MB, Hejny P, Wong PY. Formation of lipoxins by rat basophilic leukemia cells. Adv Prostaglandin Thromboxane Leukot Res. 1989;19:128-31.
127. Ng CF, Lam BK, Pritchard KA Jr, Stemerman MB, Hejny P, Wong PY. Agonist-dependent generation of lipoxins from rat basophilic leukemia cell (RBL-1). Biochim Biophys Acta. 1989 Aug 22;1004(3):332-6.
128. Pritchard KA Jr, Wong PY, Stemerman MB. Atherogenic concentrations of low-density lipoprotein enhance endothelial cell generation of epoxyeicosatrienoic acid products. Am J Pathol. 1990 Jun;136(6):1383-91. PMCID: PMC1877592
129. Pritchard KA Jr, Tota RR, Stemerman MB, Wong PY. 14, 15-Epoxyeicosatrienoic acid promotes endothelial cell dependent adhesion of human monocytic tumor U937 cells. Biochem Biophys Res Commun. 1990 Feb 28;167(1):137-42.
130. Holland JA, Pritchard KA, Pappolla MA, Wolin MS, Rogers NJ, Stemerman MB. Bradykinin induces superoxide anion release from human endothelial cells. J Cell Physiol. 1990 Apr;143(1):21-5.
131. Pritchard KA Jr, Schwarz SM, Medow MS, Stemerman MB. Effect of low-density lipoprotein on endothelial cell membrane fluidity and mononuclear cell attachment. Am J Physiol. 1991 Jan;260(1 Pt 1):C43-9.
132. Pritchard KA Jr, Tota RR, Lin JH, Danishefsky KJ, Kurilla BA, Holland JA, Stemerman MB. Native low density lipoprotein. Endothelial cell recruitment of mononuclear cells. Arterioscler Thromb. 1991 Sep-Oct;11(5):1175-81.
133. Holland JA, Pritchard KA, Rogers NJ, Stemerman MB. Atherogenic levels of low-density lipoprotein increase endocytotic activity in cultured human endothelial cells. Am J Pathol. 1992 Mar;140(3):551-8. PMCID: PMC1886169
134. Arnold JH, Pritchard KA Jr, Greco NJ, Panganamala RV. Production of platelet thromboxane A2 and arterial prostacyclin I2 from hypercholesterolemic rats. Prostaglandins Leukot Essent Fatty Acids. 1992 Jul;46(3):215-7.
135. Welak SR, Rentea RM, Teng RJ, Heinzerling N, Biesterveld B, Liedel JL, Pritchard KA Jr, Fredrich KM, Gourlay DM. Intestinal NADPH oxidase 2 activity increases in a neonatal rat model of necrotizing enterocolitis. PLoS One. 2014;9(12):e115317. PMCID: PMC4269454
136. Chadwick AC, Holme RL, Chen Y, Thomas MJ, Sorci-Thomas MG, Silverstein RL, Pritchard KA Jr, Sahoo D. Acrolein impairs the cholesterol transport functions of high density lipoproteins. PLoS One. 2015;10(4):e0123138. PMCID: PMC4388475
137. Pritchard KA Jr, Weihrauch D. A novel path of improving heart function after infarction. J Mol Cell Cardiol. 2015 Jul;84:200-1. PMCID: PMC5665170
138. Konduri GG, Afolayan AJ, Eis A, Pritchard KA Jr, Teng RJ. Interaction of endothelial nitric oxide synthase with mitochondria regulates oxidative stress and function in fetal pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 01;309(9):L1009-17. PMCID: PMC4628983
139. Yan JG, Zhang LL, Agresti M, Yan Y, LoGiudice J, Sanger JR, Matloub HS, Pritchard KA Jr, Jaradeh SS, Havlik R. Cumulative Brain Injury from Motor Vehicle-Induced Whole-Body Vibration and Prevention by Human Apolipoprotein A-I Molecule Mimetic (4F) Peptide (an Apo A-I Mimetic). J Stroke Cerebrovasc Dis. 2015 Dec;24(12):2759-73. PMCID: PMC5664147
140. Zhang H, Ray A, Miller NM, Hartwig D, Pritchard KA, Dittel BN. Inhibition of myeloperoxidase at the peak of experimental autoimmune encephalomyelitis restores blood-brain barrier integrity and ameliorates disease severity. J Neurochem. 2016 Feb;136(4):826-836. PMCID: PMC4865458
141. Yu G, Liang Y, Huang Z, Jones DW, Pritchard KA Jr, Zhang H. Erratum to: Inhibition of myeloperoxidase oxidant production by N-acetyl lysyltyrosylcysteine amide reduces brain damage in a murine model of stroke. J Neuroinflammation. 2016 Jun 27;13(1):166. PMCID: PMC4924260
142. Yu G, Liang Y, Huang Z, Jones DW, Pritchard KA Jr, Zhang H. Inhibition of myeloperoxidase oxidant production by N-acetyl lysyltyrosylcysteine amide reduces brain damage in a murine model of stroke. J Neuroinflammation. 2016 05 24;13(1):119. PMCID: PMC4879722
143. Weihrauch D, Krolikowski JG, Jones DW, Zaman T, Bamkole O, Struve J, Pillai S, Pagel PS, Lohr NL, Pritchard KA Jr. An IRF5 Decoy Peptide Reduces Myocardial Inflammation and Fibrosis and Improves Endothelial Cell Function in Tight-Skin Mice. PLoS One. 2016;11(4):e0151999. PMCID: PMC4822818
144. Afolayan AJ, Alexander M, Holme RL, Michalkiewicz T, Rana U, Teng RJ, Zemanovic S, Sahoo D, Pritchard KA Jr, Konduri GG. Domain Mapping of Heat Shock Protein 70 Reveals That Glutamic Acid 446 and Arginine 447 Are Critical for Regulating Superoxide Dismutase 2 Function. J Biol Chem. 2017 02 10;292(6):2369-2378. PMCID: PMC5313107
145. Strzepa A, Pritchard KA, Dittel BN. Myeloperoxidase: A new player in autoimmunity. Cell Immunol. 2017 Jul;317:1-8. PMCID: PMC5665680
146. Weihrauch D, Krolikowski JG, Jones DW, Zaman T, Bamkole O, Struve J, Pagel PS, Lohr NL, Pritchard KA Jr. Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice. J Vis Exp. 2017 03 24(121). PMCID: PMC5408651
147. Zemanovic S, Ivanov MV, Ivanova LV, Bhatnagar A, Michalkiewicz T, Teng RJ, Kumar S, Rathore R, Pritchard KA Jr, Konduri GG, Afolayan AJ. Dynamic Phosphorylation of the C Terminus of Hsp70 Regulates the Mitochondrial Import of SOD2 and Redox Balance. Cell Rep. 2018 11 27;25(9):2605-2616.e7. PMCID: PMC6377235
148. Schultz A, Olorundami OA, Teng RJ, Jarzembowski J, Shi ZZ, Kumar SN, Pritchard K Jr, Konduri GG, Afolayan AJ. Decreased OLA1 (Obg-Like ATPase-1) Expression Drives Ubiquitin-Proteasome Pathways to Downregulate Mitochondrial SOD2 (Superoxide Dismutase) in Persistent Pulmonary Hypertension of the Newborn. Hypertension. 2019 10;74(4):957-966. PMCID: PMC6739165
149. Nolfi-Donegan D, Pradhan-Sundd T, Pritchard KA Jr, Hillery CA. Redox Signaling in Sickle Cell Disease. Curr Opin Physiol. 2019 06;9:26-33. PMCID: PMC6592428
150. Afolayan AJ, Teng RJ, Eis A, Rana U, Broniowska KA, Corbett JA, Pritchard K, Konduri GG. Inducible HSP70 regulates superoxide dismutase-2 and mitochondrial oxidative stress in the endothelial cells from developing lungs. Am J Physiol Lung Cell Mol Physiol. 2014 Feb 15;306(4):L351-60. PMCID: PMC3920226
151. Rentea RM, Liedel JL, Fredrich K, Pritchard K Jr, Oldham KT, Simpson PM, Gourlay DM. Enteral intestinal alkaline phosphatase administration in newborns decreases iNOS expression in a neonatal necrotizing enterocolitis rat model. J Pediatr Surg. 2013 Jan;48(1):124-8. PMCID: PMC5664149
152. Pritchard KA, Rivera A, Hillery C, Brugnara C. Novel approaches to treatment Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management, Second Edition. 1 January 2009:755-773.
153. Konduri GG, Bakhutashvili I, Eis A, Pritchard K Jr. Oxidant stress from uncoupled nitric oxide synthase impairs vasodilation in fetal lambs with persistent pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1812-20.
154. Smallev DM, Curtis M, Stemerman MB, Pritchard KA. Native low density lipoprotein decreases endothelial cell tissue type plasminogen activator production via a PKC-dependent pathway FASEB Journal. 1996;10(6).
155. Clarke MSF, Pritchard KA, Medow MS, McNeil PL. An atherogenic level of native LDL increases endothelial cell vulnerability to shear-induced plasma membrane wounding and consequent release of basic fibroblast growth factor Endothelium: Journal of Endothelial Cell Research. 1996;4(2):127-139.
156. Lin JHC, Kobari Y, Zhu Y, Stemerman MB, Pritchard KA. Human umbilical vein endothelial cells express P450 2C8 mRNA: Cloning of endothelial P450 epoxygenase Endothelium: Journal of Endothelial Cell Research. 1996;4(3):219-229.
157. Smalley DM, Lin JHC, Curtis ML, Kobari Y, Stemerman MB, Pritchard KA. Native LDL increases endothelial cell adhesiveness by inducing intercellular adhesion molecule-1 Arteriosclerosis, Thrombosis, and Vascular Biology. 1996;16(4):585-590.
158. Smith CJ, Sun D, Hoegler C, Roth BS, Zhang X, Zhao G, Xu XB, Kobari Y, Pritchard K Jr, Sessa WC, Hintze TH. Reduced gene expression of vascular endothelial NO synthase and cyclooxygenase-1 in heart failure. Circ Res. 1996 Jan;78(1):58-64.
159. Sessa WC, Pritchard K, Seyedi N, Wang J, Hintze TH. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res. 1994 Feb;74(2):349-53.
160. Weihrauch D, Martin DP, Jones D, Krolikowski J, Struve J, Naylor S, Pritchard KA Jr. Inhibition of myeloperoxidase increases revascularization and improves blood flow in a diabetic mouse model of hindlimb ischaemia. Diab Vasc Dis Res. 2020 Mar-Apr;17(3):1479164120907971.
 
Abstracts
1. Pritchard Jr., KA, Greco NA and Panganamala RV. Effect of dietary cholesterol on the sensitivity of rabbit platelets to platelet activating factor (PAF). Conference on Prostaglandins and Leukotrienes 1984; Washington,D.C. Abstract-244
2. Holland JA, Pritchard Jr., KA and Stemerman MB. Sustained endothelial culture with atherogenic levels of low-density lipoprotein. Arteriosclerosis 1986; 6:540a-541a
3. Pritchard Jr., KA, Holland JA, Wong P Y-K and Stemerman MB. Perturbation of the endothelium by low-density lipoprotein: Altered eicosanoid metabolism. Clin Res 1987; 35: 575a
4. Holland JA, Pritchard Jr., KA and Stemerman MB. Low-density lipoprotein induces endothelial cell perturbation. FASEB 1987; 46:829
5. Stemerman MB, Holland JA and Pritchard Jr., KA. Effect of high concentrations of low-density lipoprotein (LDL) on endothelial cell function: Eicosanoid metabolism. Taipei conference on Prostaglandins and Leukotriene Research 1988; S41:
6. Wong P Y-K, Pritchard Jr., KA, Stemerman MB and Chao PHW. Transcellular metabolism of eicosanoids during platelet/leukocyte and endothelial cell interaction. Prostaglandin and Leukotrienes 1988;
7. Holland JA, Pritchard Jr., KA, Rogers NJ and Stemerman MB. LDL-induced endothelial endocytosis is modulated by indomethacin. Arteriosclerosis 1989; 9(5):696a
8. Pritchard Jr., KA, Tota RR, Vaisman A, Holland JA and Stemerman MB. Atherogenic LDL serum levels enhance U937 cell binding to EC through a lipoxygenase pathway. Arteriosclerosis 1989; 9(5):696a
9. Schwarz SM, Medow MS, Pritchard Jr., KA and Stemerman MB. Low-density lipoprotein effects on endothelial cell lipid dynamics and membrane function. Clinical Research 1990; 38(2):233A
10. Pritchard Jr., KA, Rimarachin J, Gerritsen M, Wong P Y-K and Stemerman MB. Effect of 14,15-epoxyeicosatrienoic acid (EET) on vascular cellular interactions and blood pressure. FASEB 1990; 4: part II:A1145
11. Pritchard Jr., KA, Lin J H-C, Zeman RJ and Stemerman MB. Native low-density lipoprotein heightens endothelial cell ELAM and ICAM expression: Role of intracellular free calcium. 1993; Mid- Atlantic Conference on Lipoproteins and Atherosclerosis, April 14-16th (Atlantic City, NJ)
12. Pritchard Jr., KA, Wu M, Villalon P, Smalley DM, Wolin MS, Zeman RJ and Stemerman MB. Native low-density lipoprotein enhances endothelial cell nitric oxide and superoxide anion generation: Potential mechanism for peroxynitrite formation. Circulation 1993; 88, number 4, part 2 abstract 1969
13. Lin J H-C, Kubari Y, Pritchard Jr., KA and Stemerman MB. Native low-density lipoprotein enhances cytochrome P450 epoxygenase activity: Cloning of human umbilical vein endothelial cell P450 IIC isozyme. Circulation 1993; 88: number 4, part 2 abstract 1218
14. Smalley DM, Stemerman MB, Lin J H-C, Zeman RJ, Villalon P and Pritchard Jr., KA. A putative intracellular calcium mechanism for native LDL induction of endothelial cell adhesion molecules. Circulation 1993; 88: number 4, part 2, abstract 0714
15. Wang J, Kubari Y, Lin J H-C, Pritchard Jr., KA, Wolin MS, Hintze TH. Mechanism of defective conversion of arachidonic acid (AA) to prostaglandins during heart failure (HF). Circulation 1993; 88: number 4, part 2, abstract 3051
16. Wu M, Kaminski PM, Fayngersh RP, Groszek L, Pritchard Jr., KA, Hintze T.H., Stemerman M.B. and Wolin M.S. Peroxynitrite induces vascular relaxation via nitric oxide. Circulation 1993; 88: number 4, part 2, abstract 2814
17. Pritchard Jr., KA, Groszek L, Smalley DM, Sessa WC, Wu M, Villalon P, Wolin MS and Stemerman MB. Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. Endothelium 1995; 2 supplement: s19.
18. Smalley DM, Curtis ML, Stemerman MB and Pritchard Jr., KA. Native LDL decreases endothelial cell tissue plasminogen activator production via a PKC-dependent mechanism. FASEB, New Orleans, LA, June 2-10, 1996
19. Baker JE, Holman P, Kalyanaraman B and Pritchard Jr., KA. Chronic mycocardial hypoxyia increases eNOS expression to produce elevated levels of nitric oxide for cardioprotection. AHA May 1996 National Meeting in New Orleans
20. Pritchard Jr., KA, Vasquez-Vivar J, Hogg N, Martasek P and Kalyanaraman B. eNOS-dependent superoxide anion production. The Oxygen Society 1996, Miami, FL
21. Vasquez-Vivar J, Martasek P, Master BSS, Hogg N, Kalyanaraman B and Pritchard Jr., KA. EPR-spin trapping evidence for the generation of superoxide by endothelial nitric oxide synthase. Circulation Supplement 1, 1997, 96(8): #1280, page I-233 AHA 70th Scientific Sessions
22. Pritchard Jr., KA, Vasquez-Vivar J, Smalley DM and Sessa WC. Low-density lipoprotein (LDL) induces eNOS superoxide anion (O2-) generation: Implications for loss of EDRF activity. Circulation Supplement 1, 1997, 96(8): #1282, page I-234 AHA 70th Scientific Sessions
23. Pritchard Jr., KA, Vasquez-Vivar J, Smalley DM and Sessa WC. Cholesterol induces eNOS superoxide anion (O2-): Implications for loss of nitric oxide activity. Circulation Supplement 1, 1997, 96(8): #1597, page I- AHA 70th Scientific Sessions
24. Kalyanarman B., Vasquez-Vivar J., Martasek P., Masters B.S.S., Hogg N., Pritchard Jr., KA. Adriamaycin-induced eNOS-dependent superoxide production: Implications for adriamycin mediated cytotoxicity. Circulation Supplement 1, 1997, 96(8): #3378, page I-605 AHA 70th Scientific Sessions
25. Vasquez-Vivar J, Hogg N, Martasek P, Kalyanaraman B. and Pritchard Jr., KA. Mechanisms of dichromate activation of endothelial cells. 1997, The Oxygen Society Meeting, San Fransico, CA
26. Baker JE, Holman P, Kalyanaraman B, Griffith OW, Pritchard Jr., KA. Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production. Circulation. 1998;98:620.
27. Vivar JMV, Pritchard Jr., KA, Martasek P, Hogg N. Tetrahydrobiopterin regulates the generation of superoxide and nitric oxide by endothelial nitric oxide. Circulation. 1998;98:395.
28. Vivar JMV, Martasek P, Hogg N, Pritchard Jr., KA, Kalyanaraman B. Tetrahydrobiopterin-dependent regulation of superoxide from eNOS. Free Radical Biology and Medicine. 1998;25:S25-S25.
29. Pritchard Jr., KA and Kalyanaraman B. Cyclic guanosine monophosphate (cGMP): An intracellular measure of superoxide anion? The Gordon Research Conference on Free Radicals (Feb 1998)
30. Srigiridhar K, Konerev E, Pritchard Jr., KA and Kalyanaraman B. Doxerubicin-induced apoptosis is reversed by nitrone spin traps and Ebselen. 1999, The Oxygen Society Meeting, New Orleans, LA.
31. Hanke CJ, Pritchard Jr., KA, O'Brien T, Campbell WB. Infection of adrenal zona glomerulosa cells with endothelial-nitric oxide synthase adenovirus: Inhibition of aldosterone synthesis by endogenous nitric oxide. Hypertension. 1999;34:351.
32. Vasquez-Vivar J, Hogg N, Martasek P, Karoui H, Pritchard Jr., KA, Tordo P, Kalyanaraman B. Mechanism of tetrahydrobiopterin-mediated inhibition of superoxide generation by nNOS. Free Radical Biology and Medicine. 1999;27:S88.
33. Vivar JMV, Hogg N, Martasek P, Pritchard Jr., KA, Kalyanaraman B. Tetrahydrobiopterin modulates formation of reactive oxygen and reactive nitrogen species by NOS. Circulation. 1999;100:702.
34. Pritchard Jr., KA and Ackerman A. Native low-density lipoprotein (nLDL) increases NOS3 activity in endothelial cells (EC): Role of caveolin-1. The FASEB Journal 14(4) Abstract #325.1, page A449 (2000).
35. Shi Y, Pritchard Jr., KA, Griffith O and Baker, JE. Chronic hypoxia protects against ischemia in neonatal rabbit hearts by increasing NOS3 activity. The FASEB Journal 14(4) Abstract #441.6, page A586 (2000).
36. Shi Y, Pritchard Jr., KA, Griffith O and Baker, JE. Chronic hypoxia decreases expression of caveolin-3 in neonatal rabbit hearts: Implications for NOS3 activity and protection against global ischemia. The FASEB Journal 14(4) Abstract #441.7, page A586 (2000).
37. Go Y.-M., Boo Y., Park H., Maland M.C., Patel R., Darley-Usmar V, Pritchard, Jr., KA, Fujio Y., Walsh K. and Jo H. Akt/Protein kinase B regulates Flow-dependent activation of cJun and N-terminal Kinase by producing nitric oxide from endothelial nitric oxide synthase. The FASEB Journal 14(4) Abstract #303.10, page A403 (2000).
38. Pritchard Jr., KA, Ackerman A, Vasquez-Vivar JV and Kalyanaraman B. The pollutant dichromate [Cr(VI)] shifts oxidant balance and promotes inflammation by increasing ICAM-1. The FASEB Journal 14(4) Abstract #135.7, page A174 (2000).
39. Rafiee P, Shi Y, Pritchard Jr., KA, Tweddell JS, Litwin SB, Mussato K, Baker JE. Human and rabbit hearts adapt to chronic hypoxia by activation of protein kinase signal transduction pathways. Circulation. 2000;102:156.
40. Pritchard Jr., KA, Ackerman AW, Smalley DM. Native low-density lipoprotein (n-LDL) does not inhibit endothelial nitric oxide synthase (eNOS) activity by increasing caveolin-1 (Cav-1) levels. The FASEB Journal. 2001;15:A583.
41. Pritchard Jr., KA, Ackerman AW, Gross E. Dichromate [Cr(VI)] Disrupts Interactions Between Endothelial Nitric Oxide Synthase (eNOS) and Heatshock Protein 90 (Hsp90): Implications for shifts in nitric oxide (•NO) and superoxide anion (O2•) balance. The FASEB Journal. 2001;15:A585.
42. Stepp DW, Ackerman AW, Pritchard Jr., KA. Native LDL induces eNOS-dependent superoxide formation in endothelial cells in situ. The FASEB Journal. 2001;15:A246.
43. Nowak DM, Ackland-Berglund CE, Lo HP, Schwensow NM, Pritchard Jr., KA, Guice KS, Oldham KT. Pulmonary microvascular endothelial cells express less inducible nitric oxide synthase in response to endotoxemia than pulmonary artery endothelial cells in vivo. The FASEB Journal. 2001;15:A855.
44. Pritchard Jr., KA, Gross E, Ackerman AW, Stepp DW, Fontana J, Sessa WC. Heat shock protein 90 (Hsp90) regulates endothelial nitric oxide synthase (eNOS) generation of nitric oxide (•NO) and superoxide anion (O2•). The FASEB Journal. 2001;15:A781.
45. Shi Y, Pritchard Jr., KA, Kong X, Tweddell J and Baker J. Hsp90 Mediates NOS3-dependent cardioprotection in chronic hypoxia. Circulation Abstract # 1261, 2001.
46. Pritchard Jr., KA, Stepp DW and Konduri GG. Inhibition of heat shock protein 90 activity impairs vasorelaxation by increasing superoxide anion (O2•-) generation by endothelial nitric oxide synthase (eNOS). Circulation (73rd AHA Meeting, Anaheim, CA) Abstract # 500, 2001.
47. Konorev EA, Shi Y, Kotamraju S, Kalivendi S, Pritchard Jr., KA, Baker JE, and Kalyanaraman R. Endothelial nitric oxide synthase induced by doxyrubcin in cardiomyocytes contributes to oxidative stress and apoptotic cell death. Circulation (73rd AHA Meeting, Anaheim, CA) Abstract # 452, 2001.
48. Koshida R, Pritchard Jr., KA, Chilian WM. Angiostatin inhibits, nitric oxide-mediated dilation. The FASEB Journal. 2002;16:A123-A123.
49. Ou J, Ou Z, Ackerman AW, Oldham KT, Pritchard Jr., KA. Inhibition of heat shock protein 90 (HSP90) uncouples endothelial nitric oxide synthase activity independent of oxidative stress. Free Radical Biology & Medicine, 2002;33 (suppl 2), S323. 9th Annual Meeting of The Oxygen Society. San Antonio, Texas, the United States, 2002;11.
50. Ou J, Ou Z, McCarver DG, Hines RN, Oldham KT, Ackerman AW, Pritchard Jr., KA. Trichloroethylene decreases heat shock protein 90 interactions with endothelial nitric oxide synthase: Implications for endothelial cell proliferation. Free Radical Biology & Medicine, 2002;33 (suppl 2), S417. 9th Annual Meeting of The Oxygen Society. San Antonio, Texas, the United States, 2002;11.
51. Shi Y, Baker JE, Zhang CY, Tweddell JS, Su JD, Pritchard Jr., KA. Chronic hypoxia increases NOS3 activity by association with hsp90 and serine phosphorylation. Journal of Molecular and Cellular Cardiology. 2002;34:A25.
52. Franciosi JP, Pritchard Jr., KA, Ou J, Shi Y, Ou Z, Ackland-Burglund C, Witte K, Guice K, Oldham KT, Hillery CA. Hypoxia-induced acute lung injury in murine models of sickle cell disease. Free Radical Biology & Medicine, 2002;33 (suppl 2), S366. 9th Annual Meeting of The Oxygen Society. San Antonio, Texas, the United States, 2002;11.
53. Hillery CA, Holzman SA, Franciosi JP, Ou JS, Ou ZJ, Mohandas N, Guice K, Oldham KT, Pritchard Jr., KA. Changes in hsp90-eNOS interactions following hypoxia-induced acute lung injury in a murine model of sickle cell disease. Blood. 2002;100:11A-11A.
54. Pritchard Jr., KA, Koshida R, Ou J, Matsunaga T, Oldham KT, Ackerman AW, Chilian WM. Angiostatin, a negative regular of endothelial function. Experimental Biology Conference 2002, New Orleans, Louisiana, the United States, 2002;4, LB272
55. Ou J, Ou Z, Jones DW, Ackerman AW, Hillery CA, Gutterman DD, Guice KS, Oldham KT, Pritchard Jr., KA. 4F, an apo A-I mimetic preserves acetylcholine induced vasodilation of carotid arterioles in sickle cells mice. FASEB J, 2003;17(4):A371. Experimental Biology Conference(FASEB) 2003: San Diego, California, the United States, 2003;4.
56. Ou J, Ou Z, Jones DW, Weihrauch D, Ackerman AW, Gutterman DD, Guice KS, Oldham KT, Pritchard Jr., KA. An apo A-I mimetic peptide preserves vasodilation in hypercholesterolemic mice. FASEB J, 2003;17(4):A513. Experimental Biology Conference(FASEB) 2003: San Diego, California, the United States, 2003;4.
57. Ou Z, Ou J, Ackerman AW, Oldham KT, Pritchard Jr., KA. 4F, an apo A-I mimetic prevents LDL-induced endothelial dysfunction. FASEB J, 2003;17(4):A805. Experimental Biology Conference(FASEB) 2003: San Diego, California, the United States, 2003;4.
58. Ou J, Ou Z, Jones DW, Weihrauch D, Ackerman AW, Gutterman DD, Guice KS, Oldham KT, Pritchard Jr., KA. An Apolipoprotein A-1 (apo A-1) mimetic, preserves endothelial- and eNOS-dependent vasodilation in hypercholesterolemia. 4th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology: Washington, DC, the United States, 2003;5: 122.
59. Ou Z, Ou J, Ackerman AW, Oldham KT, Pritchard Jr., KA. 4F, an apo A-I mimetic prevents LDL-induced endothelial dysfunction. 4th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology: Washington, DC, the United States, 2003;5:112.
60. Ou J, Ou Z, Jones DW, Oldham KT, Pritchard Jr., KA. D-4F restores endothelium- and eNOS-dependent vasodilation and reduces vessel wall thickness in hypercholesterolemia. American Heart Association Scientific Sessions 2003; 108(17) Abstract # 1334.
61. Shi Y, Rafiee P, Su J, Pritchard Jr., KA, Tweddell JS, Baker JE. Acute cardioprotective effects of erythropoetin are mediated by activation of protein kinases and potassium channels. American Heart Association Scientific Sessions 2003; 108(17) Abstract # 1299.
62. Baker JE, Shi Y, Pritchard Jr., KA, Heidemann J, Jacob HJ, Lazar J, Rafiee P. Functional proteomic analysis: Evidence for cardioprotective proteins in the Brown Norway vs Dahl S rat. The FASEB Journal. 2003;17:A159.
63. Rafiee P, Heidemann J, Ogawa H, Johnson NA, Fisher PJ, Li MS, Otterson MF, Johnson CP, Pritchard Jr., KA, Binion DG. Cyclosporin A differentially inhibits multiple steps in VEGF induced angiogenesis in human intestinal microvascular endothelial cells through altered intracellular signaling. The FASEB Journal. 2004;18:A1014.
64. Rafiee P, Shi Y, Pritchard Jr., KA, Johnson NA, Jacob HJ, Baker JE. Activation of p44/42 MAPK and HSP70i contributes to ischemic cardioprotection in Brown Norway but not Dahl S rats. The FASEB Journal. 2004;18:A1003.
65. Rafiee P, Shi Y, Pritchard Jr., KA, Baker JE. Erythropoetin protects rabbit heart against subsequent ischemia-reperfusion injury: Role of protein kinases. The FASEB Journal. 2004;18:A390.
66. Densmore JC, Signorino PR, Pritchard Jr., KA, Oldham KT. Endothelial microparticles inhibit endothelium-mediated vasodilation. Shock. 2004;21:64-65.
67. Konduri GG, Ou JS, Shi Y, Pritchard Jr., KA. Decreased association of heat shock protein 90 (hsp90) impairs endothelial nitric oxide synthase (eNOS) in fetal lambs with persistent pulmonary hypertension of newborn (PPHN). Pediatric Research. 2003;53:352A.
68. Ou J, Sorci-Thomas M, Jones DW, Oldham KT, Pritchard Jr., KA. D-4F, an apo A-1 mimetic, increases vasodilation in hypercholesterolemic, apo A-1-deficient mice. American Heart Association Scientific Sessions 2004.
69. Sander TL, Noll L, Weihrauch D, Densmore JC, Pritchard Jr., KA, Baker JE, Oldham KT. PPAR gamma antagonizes VEGF signaling in endothelial cells by inhibiting NFATc1. The FASEB Journal. 2005;19:A1041.
70. Xu H, Wang JL, Wakim BTT, Pritchard Jr., KA, Shi Y. Decoy peptides disrupt heat shock protein 90 association with endothelial nitric oxide synthase and block stimulated nitric oxide production. The FASEB Journal. 2005;19:A733.
71. Wang JL, Hillery CA, Jones DW, Holzhauer S, Foster T, Densmore J, Signorino P, Oldham KT, Pritchard Jr., KA. D-4F, an apo A-1 mimetic, increases vasodilation in LDL receptor knockout/sickle cell disease mice. The FASEB Journal. 2005;19:A486.
72. Ou JS, Sorci-Thomas M, Jones DW, Oldham KT, Pritchard Jr., KA. D-4F, an apolipoprotein A-1 mimetic, increases vasodilation in hypercholesterolemic, apolipoprotein A-1-deficient mice. Circulation. 2004;110:243.
73. Densmore JC, Doffek K, Kaul S, Pritchard Jr., KA, Guice KS, Oldham KT, Shilyansky J. Endothelium-derived microparticles induce dendritic cell apoptosis. Journal of the American College of Surgeons. 2005;201:S31.
74. Wang JL, Xu H, Shi Y, Ying R, Kaul S, Oldham KT, Pritchard Jr., KA. Endostatin impairs endothelium-dependent vasodilation by uncoupling eNOS and decreasing •NO production. Circulation. 2005;112:U354.
75. Ou JS, Densmore JC, Kaul S, Jones DW, Pritchard Jr., KA, Guice KS, Oldham KT. Endothelium-derived microparticles induce endothelial cell superoxide generation. Circulation. 2005;112:U159-U160.
76. Pritchard Jr., KA, Besch TL, Wang JL, Xu H, Jones DW, Foster TD, Holzhauer SL, Oldham KT, Wandersee NJ, Hillery CA. Differential effects of lovastatin and allopurinol therapy in a murine model of sickle cell disease. Blood. 2005;106:654A.
77. Pritchard Jr., KA, Wang JL, Xu H, Jones DW, Holzhauer SL, Foster TD, Oldham KT, Hillery CA. D-4F restores eNOS-dependent vasodilation in sickle cell disease by decreasing proinflammatory HDL. Blood. 2005;106:654A.
78. Pritchard Jr., KA, Wang JL, Xu H, Jones DW, Holzhauer SL, Foster TD, Oldham KT, Hillery CA. D-4F restores eNOS-dependent vasodilation in sickle cell disease by decreasing proinflammatory HDL. Blood. 2005;106:654A.
79. Schraufnagel AC, Piknova B, Pritchard Jr., KA, Hogg N, Wandersee NJ. Nitric oxide scavenging, abnormal vasoregulation and oxidative damage in sph/sph mice with severe hereditary spherocytosis: Possible consequences of red blood cell hemolysis. Blood. 2005;106:474A.
80. Sander TL, Klinkner DB, Densmore JC, Kaul S, Noll L, Weihrauch DC, Pritchard Jr., KA, Oldham KT. Endothelium-derived microparticles inhibit human mitral valve endothelial cell function. The FASEB Journal. 2006;20:A1075.
81. Ou JS, Densmore JC, Kaul S, Guice KS, Pritchard Jr., KA, Oldham KT. D-4F, an apolipoprotein A-1 mimetic, inhibits endothelium-derived microparticles-induced endothelial nitric oxide synthase dysfunction. The FASEB Journal. 2006;20:A290.
82. Wang JL, Klinkner DB, Sander TL, Noll LA, Oldham KT, Pritchard Jr., KA. D-4F, an apoA-I mimetic, protects endothelium-dependent vasodilation and endothelial cell proliferation against the inhibitory effects of POVPC. The FASEB Journal. 2006;20:A206.
83. Xu H, Wang JL, Ou JS, Jones DW, Oldham KT, Hillery CA, Pritchard Jr., KA. Reciprocal binding of xanthine. oxidase and myeloperoxidase with ApoA-I correlates with HDL anti- and pro-inflammatory properties. The FASEB Journal. 2006;20:A198-A199.
84. Cheng J, Ou JS, Singh H, Williams J, Pritchard Jr., KA, Schwartzman ML. 20-hydroxyeicosatetraenoic acid brings about endothelial dysfunction via eNOS uncoupling. The FASEB Journal. 2007;21:A862.
85. Ou JS, Kaul SM, Greene AS, Pritchard Jr., KA, Oldham KT, Sander TL. Comparative proteome analysis of PAI-1 and TNF-alpha-derived endothelial microparticles. The FASEB Journal. 2007;21:A181.
86. Nandedkar SD, Konduri KS, Wang J, Xu H, Shi Y, Rickaby DA, Duzgunes N, Pritchard Jr., KA. The effect of daily apolipoprotein A-I mimetic therapy on pro-inflammatory high density lipoprotein in a murine model of asthma. Journal of Allergy and Clinical Immunology. 2007;119:S290.
87. Konduri KS, Nandedkar SD, Weilrauch D, Rickaby DA, Duzgunes N, Pritchard Jr., KA. The effect of daily apolipoprotein A-I mimetic therapy on T15-type autoantibodies against oxidized phosphatidylcholine in a murine model of asthma. Journal of Allergy and Clinical Immunology. 2007;119:S128-S128.
88. Xu H, Pritchard Jr., KA, Wakim B, Olivier M, Shi Y. Proteomic analysis of proteins bound by D-4F in plasma from C57BL/6 and ApoA-I KO mice. Circulation. 2007;116:300.
89. Xu H, Shi Y, Pritchard Jr., KA. E310, 314, 318 and 323 in eNOS play a critical role in maintaining eNOS-hsp90 interactions and coupled eNOS activity. Circulation. 2007;116:233.
90. Larsen BT, Bubolz AH, Pritchard Jr., KA, Gutterman DD. NADPH oxidase-derived reactive oxygen species are required for flow-induced dilation of human coronary arterioles. Circulation. 2007;116:232.
91. Ataga KI, Hillery CA, Park HA, Moore CG, Jones S, Wang J, Hinderliter A, Pritchard Jr., KA. Proinflammatory lipids in sickle cell disease-associated pulmonary hypertension. Blood. 2007;110:17B-18B.
92. Wandersee NJ, Frei AC, Holzhauer SL, Scott JP, Pritchard Jr., KA, Fagan KA, Hogg N, Hillery CA. Vascular dysfunction in marine models of hemolytic anemia. Blood. 2007;110:259A.
93. Du J, Xu H, Wei N, Wakim B, Pritchard Jr., KA, Shi Y. Identification of proteins interacting with GTP cyclohydrolase I. The FASEB Journal. 2008; Abstract
 
Non-Peer Reviewed Educational Products
1. Patent: hsp90 Decoy Peptides and Uses Thereof. Filed - August 2006
2. Provisional Patent: Peroxidase Inhibitors and Uses Thereof. Filed - October 2009
 

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