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CURRICULUM VITAE

Larisa Broglie MD, MS
Assistant Professor
Department of Pediatrics
Division of Hematology and Oncology - Pediatrics

OFFICE ADDRESS:
Children's Hospital
9000 W Wisconsin Ave
Milwaukee, WI 53226

EDUCATION:
08/2002 - 06/2006 Bachelor of Science, Biology/Chemistry Interdisciplinary Major, Summa Cum Laude, Loyola University in Maryland,, Baltimore, MD
08/2006 - 06/2010 Medical Doctorate, Jefferson Medical College,, Philadelphia, PA
08/2017 - 05/2018 Masters of Clinical and Translational Research, Medical College of Wisconsin, Milwaukee, WI

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
07/2010 - 06/2013 Pediatric Resident, Pediatrics, Children’s Memorial Hospital Northwestern University Feinberg School of Medicine, Chicago, IL
07/2013 - 06/2016 Pediatric Hematology/Oncology/Stem Cell Transplant Fellow, Pediatrics, Pediatric Hematology, Oncology, Ann and Robert H. Lurie Children’s Hospital of Chicago Northwestern University Feinberg School of Medicine, Chicago, IL
07/2016 - 05/2018 James Casper Pediatric Blood and Marrow Transplant & Research Fellow, Pediatrics, Pediatric Hematology, Oncology, Blood and Marrow Transplantation, Milwaukee, WI

SPECIALTY BOARDS AND CERTIFICATION:
Board Certified
Issue DateExpiration
USMLE Step 1, passed
2008
None
USMLE Step 2, passed
2009
None
USMLE Step 3, passed
2012
None
American Board of Pediatrics, Pediatric Board Exam, passed
2013
None
AAP Pediatric Hematology/Oncology Board Exam, passed
2017
None
 
Licensure
Number Issue DateExpiration
Physician and Surgeon
07/2010
07/2017
Medicine and Surgery
08/2016
None
Medicine and Surgery
12/2017
None
Medicine and Surgery
09/2020
None
 

AWARDS AND HONORS:
2016 James Casper Pediatric Blood and Marrow Transplant & Research Fellow, Medical College of Wisconsin
2017 Clinical Research Training Course Scholar, American Society of Blood and Marrow Transplant
2018 Department of Pediatrics Award for Best Fellowship Research Project and Presentation, Medical College of Wisconsin

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
04/2006 - Present Phi Beta Kappa (Member )
04/2006 - Present Alpha Sigma Nu (Member )
08/2006 - 06/2010 American Medical Association (Member)
06/2009 - 06/2010 Hobart Amory Hare Society (Member)
07/2010 - 07/2013 American Academy of Pediatrics (Member)
07/2013 - 07/2016 American Society of Hematology (Member)
07/2016 - Present American Society of Pediatric Hematology/Oncology (Member)
08/2016 - 05/2018 CIBMTR – Cellular Therapy Forum (Member)
09/2016 - Present American Society of Blood and Marrow Transplantation (Member)
09/2016 - Present Pediatric Blood and Marrow Transplant Consortium (PBMTC) (Supportive Care Committee Member )
09/2016 - Present Regiment Related Toxicity, Pediatric Cancer, Non-Malignant Diseases, Late Effects (CIBMTR Working Committee Member)

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Prior
Peer Review
Title:
CTSI National Research Service Awards TL1 grant
Source:
NIH Grant Numbers UL1TR001436 and 1TL1TR001437
Dates:
08/2016 - 08/2017
 
Title:
CTSI National Research Service Awards TL1 grant
Source:
NIH Grant Numbers UL1TR001436 and 1TL1TR001437
Dates:
08/2017 - 08/2018
 
Non-Peer Review
Title:
PBMTC/ASPHO Young Investigator Travel Award
Dates:
05/2016
 
Title:
PBMTC/ASPHO Young Investigator Travel Award
Dates:
05/2017
 

COMMITTEE SERVICE:
Medical College of Wisconsin
09/2020 - Present Assistant Scientific Director, Pediatric Cancer Working Committee, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin
 
Hospital
05/2018 - Present Co-Leader, Fellowship Subcommittee of the Supportive Care Committee, Pediatric Blood and Marrow Transplant Consortium
03/2019 - 09/2020 Member, Institutional Steering Committee, North American Pediatric Aplastic Anemia Consortium, Columbia University Medical Center
04/2019 - 09/2020 Associate Medical Director, 5 Tower (Oncology/Bone Marrow Transplant Unit), Columbia University Medical Center
09/2019 - 09/2020 Member, Central Line Task Force, Columbia University Medical Center
02/2020 - 09/2020 Institutional Primary Investigator, Primary Immune Deficiency Treatment Consortium, Columbia University Medical Center
09/2020 - Present Clinical Director, BMT and Cellular Therapy Immune Deficiency & Dysregulation Team, Children’s Hospital of Wisconsin
09/2020 - Present Institutional Primary Investigator, Primary Immune Deficiency Treatment Consortium, Children’s Hospital of Wisconsin
09/2020 - Present Member, Institutional Steering Committee, North American Pediatric Aplastic Anemia Consortium, Children’s Hospital of Wisconsin
10/2020 - Present Member, Children’s Oncology Group Supportive Care Guideline Committee, Children’s Hospital of Wisconsin
 

EXTRAMURAL TEACHING:
Medical Student Education
08/2005 - 06/2006 Loyola University in Maryland, Organic Chemistry Tutor
07/2010 - 06/2013 Northwestern University Feinberg School of Medicine, Pediatric Hematology/Oncology Lecture Pediatrics Rotation, Medical Students
 


BIBLIOGRAPHY
Abstracts
1. Mahajan R, Lipton M, Broglie L, Jain NG, Uy NS. Eculizumab treatment for renal failure in a pediatric patient with COVID-19. J Nephrol. 2020; doi: 10.1008/s40620-020-00858-2.
2. Philips L, Pavisic J, Kaur D, Dorrello NV, Broglie L, Hijiya N. Successful management of SARS-CoV-2 acute respiratory distress syndrome and newly diagnosed acute lymphoblastic leukemia. Blood Adv. 2020; 4(18): 4358-4361. Doi: 10.1182/bloodadvances.2020002745.
3. Broglie L, Vitola B, Thakar MS, Basel D, Szabo S, Agni R, Talano JA. Hemophagocytic Lymphohistiocytosis mimicking neonatal hemochromatosis. Pediatr Hematol Oncol. 2019. Doi:10.1080/08880018.2019/1654051
4. Broglie L, Phelan R, Talano J. First report that prior ECMO therapy does not preclude hematopoietic cell transplantation. Pediatr Hematol Oncol. 2018; 35(4): 245-249. doi:10.1080/08880018.2018.1505989
5. Broglie L, Gershan J, Burke M. Check-point Inhibition of PD-L1 and CTLA-4 in a Child with Refractory Acute Leukemia. Int J Hematol Oncol 2019; 8(1):IJH10. doi: 10.2217/ijh-2018-0009
6. Broglie L, Pommert L, Rao S, Thakar M, Phelan R, Margolis D, Talano JA. Ruxolitinib for Treatment of Refractory Hemophagocytic Lymphohistiocytosis. Blood Adv. 2017; 1(19): 1533-1536. doi: 10.1182/bloodadvances.2017997526.
7. Cellular Therapies for Pediatric Acute Lymphoblastic Leukemia. Larisa Broglie Oral Presentation at the Transplantation and Cellular Therapy Meetings (TCT) of ASBMT and CIBMTR, February 2019
8. Pre-Transplant Predictors of Cost of First Hospitalization for Pediatric Allogeneic Hematopoietic Cell Transplantation (alloHCT). Larisa Broglie, Zhezhen Jin, Prakash Satwani. Poster presented at Transplantation and Cellular Therapy Meetings (TCT) of ASBMT and CIBMTR, February 2019
9. Evaluation of the Hematopoietic Cell Transplant Comorbidity Index (HCT-CI) in Recipients of Allogeneic Transplantation for Immune Deficiencies. Larisa Broglie, Monica Thakar, Brent Logan, Andrew Artz, David Jacobsohn, Nancy Bunin, Lauri Burroughs, Caridad Martinez, Adam Nelson, Ann Woolfrey, Marcelo Pasquini, Mohamed Sorror. Oral Presentation at the Primary Immune Deficiency Treatment Consortium (PIDTC) meeting May 2018
10. Evaluation of the Hematopoietic Cell Transplantation Comorbidity Index in Recipients of Allogeneic Transplantation for Non-Malignant Diseases. Monica Thakar, Larisa Broglie, Brent Logan, Andrew Artz, David Jacobsohn, Nancy Bunin, Lauri Burroughs, Caridad Martinez, Adam Nelson, Ann Woolfrey, Marcelo Pasquini, Mohamed Sorror. Oral Presentation at the European Society for Blood and Marrow Transplant (EBMT) Conference, March 2018
11. Evaluation of the Hematopoietic Cell Comorbidity Index (HCT-CI) in Recipients of Allogeneic Transplantation for Non-Malignant Diseases. Broglie L, Thakar M, Logan B, Artz A, Jacobsohn D, Bunin N, Burroughs L, Martinez C, Nelson A, Woolfrey A, Pasquini M, Sorror M. Oral presentation to given at CIBMTR/ASBMT Tandem meeting Februrary 2018
12. Spontaneous improvement of severe T cell lymphopenia detected by newborn screening. Broglie L, Thakar M, Verbsy J, Routes J. Oral presentation at Primary Immune Deficiency Treatment Consortium (PIDTC) meeting May 2017
13. Stabilization of Pulmonary Function in Pediatric and Young Adult Sickle Cell Disease (SCD) Recipients undergoing Myelo-Immunesuppressive (MIC) and Familial Haploidentical (FHI) Transplantation Enriched CD34 Selection and T-cell Add-Back Broglie L, Talano JA, Moore T, Shenoy S, Mahanti H, Morris E, Horowitz T, Fabricatore S, Abikoff C, Dozor A, Cairo M Poster presented at PBMTC/ASPHO meeting April 2017
14. Treatment of Pulmonary Disease post HCT with High Dose Steroids at the Children's Hospital of Wisconsin Simon Newsom, Allison Bock, Larisa Broglie, Michelle Leveque, Julie-An Talano Poster presented at PBMTC/ASPHO meeting April 2017
15. Trajectories of Children’s Health-Related Quality of Life after Myeloimmuno Ablative Conditioning Familial Haploidentical T-Cell Depleted with T-Cell Addback Stem Cell Transplantation for Poor Risk SCD Parsons SK, Rodday AM, Weidner RA, Morris E, Moore TB, Shenoy S, Talano J-A, Broglie L, Minzer S, Fabricatore S, Braniecki S, Cairo MS Poster presented at CIBMTR/ASBMT Tandem meeting February 2017
16. Fecal calprotectin – a useful tool to predict steroid responsiveness of gastrointestinal acute graft versus host disease Larisa Broglie MD, Alfred Rademaker, John Galvin MD, Ayita Ray MD, William T. Tse MD, Reggie Duerst MD, Jennifer Schneiderman MD,MS, Morris Kletzel MD, Sonali Chaudhury MD Poster presented at the ASBMT/CIBMTR meeting February 2016 Poster presented at ASPHO meeting April 2016
17. Predicting Relapse post-Hematopoietic Stem Cell Transplant for Pediatric AML and MDS Larisa Broglie MD, Irene Helenowski MD, Larry Jennings MD PhD, Kristian Schafernak MD, Reggie Duerst MD, William T. Tse MD PhD, Morris Kletzel MD, Jennifer Schneiderman MD, Sonali Chaudhury MD Poster presented at the ASBMT/CIBMTR meeting February 2015
18. Growth and Bone Health after Hematopoietic Stem Cell Transplantation or Tyrosine Kinase Inhibitors in Children with Chronic Myeloid Leukemia: A Single Institution Experience Dilley K, Broglie L, Chaudhury S, Hijiya N. Poster presented at the International Conference on Children’s Bone Health. 2013
19. Survival after Hematopoietic Stem Cell Transplantation (HSCT) or Tyrosine Kinase Inhibitors (TKI) in Children with Chronic Myeloid Leukemia(CML) in Chronic Phase: A Single Institution Experience Sonali Chaudhury, Larisa Broglie, Alfred W Rademaker, Irene B Helenowski, Karina Danner-Koptik, Joanna Weinstein, Reggie Duerst, Morris Kletzel, Elaine Morgan, Kimberley Dilley and Nobuko Hijiya. Poster presented at the European School of Hematology Conference on Chronic Myeloid Leukemia. 2013
20. Survival after Hematopoietic Stem Cell Transplantation (HSCT) or Tyrosine Kinase Inhibitors (TKI) in Children with Chronic Myeloid Leukemia Sonali Chaudhury, Larisa Broglie, Alfred W Rademaker, Irene B Helenowski, Karina Danner-Koptik, Joanna Weinstein, Reggie Duerst, Morris Kletzel, Elaine Morgan, Kimberley Dilley and Nobuko Hijiya. Poster presented at ASPHO. 2012
21. Stem Cell Transplant (HSCT) in Pediatric CML – Is transplantation the standard of care? The Children's Memorial Hospital experience Sonali Chaudhury, Larisa Broglie, Alfred W Rademaker, Irene B Helenowski, Karina Danner-Koptik, Joanna Weinstein, Reggie Duerst, Morris Kletzel, Elaine Morgan, Kimberley Dilley and Nobuko Hijiya. Poster presented at the ASBMT/CIBMTR. 2012
22. Prevalence of Abdominal Pain Related Functional Gastrointestinal Disorders in Pediatric Recipients of Hematopoietic Stem Cell Transplant Sonali Chaudhury, Larisa Broglie, Karina Danner-Koptik, Kimberly Dilley, Morris Kletzel, Miguel Saps. Prevalence of Abdominal Pain Related Functional Gastrointestinal Disorders in Pediatric Recipients of Hematopoietic Stem Cell Transplant. Biology of Blood and Marrow Transplant, Vol. 19, Issue 2, S212. Presented at ASBMT February, 2013
 
Peer Reviewed Educational Products
1. Broglie L, Ruiz J, Jin Z, Kahn JM, Bhatia M, George D, Garvin J, Satwani P. Limitations of Applying the Hematopoietic Cell Transplantation Comorbidity Index in Pediatric Patients Receiving Allogeneic Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2020. Doi: 10.1016/j.bbmt.2020.10.003.
2. Jonat B, Gorelik M, Boneparth A, Geneslaw AS, Zachariah P, Shah A, Broglie L, Duran J, Morel KD, Zorrilla M, Svoboda L, Johnson C, Cheng J, Garzon MC, Silver WG, Margolis KG, Neunert C, Lytrivi I, Milner J, Kernie SG, Cheung EW. Multisystem Inflammatory Syndrome in Children Associated with Coronavirus Disease 2019 in a Children’s Hospital in New York City: Patient Characteristics and an Institutional Protocol for Evaluation, Management, and Follow-Up. Pediatr Crit Care Med. 2020; doi: 10.1097/PCC.0000000000002598.
3. Falcon CP, Broglie L, Phelan R, Choi SW, Auletta JJ, Chewning JH. Infection prophylaxis patterns following pediatric autologous hematopoietic stem cell transplantation: A survey of Pediatric Transplant and Cell Therapy Consortium centers. Pediatr Transplant. 2020. Doi: 10.1111/petr.13821.
4. Gampel B, Troullioud Lucas AG, Broglie L, Gartrell-Corrado RD, Lee MT, Levine J, Orjuela-Grimm M, Satwani P, Glade-Bender J, Roberts SS. COVID-19 disease in New York City pediatric hematology and oncology patients. Pediatric Blood Cancer. 2020. Doi: 10.1002/pbc.28420
5. Kahn JM, Brazauskas R, Tecca HR, Bo-Sabait S, Buchbinder D, Battiwala M, Flowers MED, Savani BN, Phelan R, Broglie L, Abraham AA, Keating AK, Daly A, Wirk B, George B, Alter BP, Ustun C, Freytes CO, Beitinjaneh AM, Duncan C, Copelan E, Hildebrandt GC, Murthy HS, Lazarus HM, Auletta JJ, Myers KC, Williams KM, Page KM, Vrooman LM, Norkin M, Byrne M, Diaz MA, Kamani N, Bhatt NS, Rezvani A, Farhadfar N, Mehta PA, Hematti P, Shaw PJ, Kamble RT, Schears R, Olsson RF, Hayashi RJ, Gale RP, Mayo SJ, Chhabra S, Rotz SJ, Badawy SM, Ganguly S, Pavletic S, Nishihori T, Prestidge T. Agrawal V, Hogan WJ, Inamoto Y, Shaw BE, Satwani P. Subsequent neoplasms and late mortality in children undergoing allogeneic transplantation for nonmalignant diseases. Blood Adv. 2020. Doi: 10.1182/bloodadvances.2019000839
6. Wobma H, Jin Z, Moscoso S, Bhatia M, Broglie L, George D, Garvin J, Satwani P. Risk factors, clinical outcomes, and cost-of-care related to graft failure in pediatric allogeneic hematopoietic cell transplant recipients”. Biol Blood Marrow Transplant. 2020. Doi: 10.1016/j.bbmt.2020.03.009
7. Ricci A, Jin Z, Bourgeois W, Broglie L, Bhatia M, Davis L, George D, Garvin JH, Hall M, Ruiz J, Satwani P. Financial impact of post-transplant complications among children undergoing allogeneic hematopoietic cell transplantation. Bone Marrow Transplant. 2020. Doi: 10.1038/s41409-020-0899-0
8. Ricci A, Jin Z, Broglie L, Bhatia M, George D, Garvin JH, Hall M, Satwani P. Healthcare utilization and financial impact of acute-graft-versus host disease among children undergoing allogeneic hematopoietic cell transplantation. Bone Marrow Transplant. 2019. Doi:10.1038/s/41409-019-0688-9
9. Broglie L, Fretham C, Al-Seraihy A, George B, Kurtzberg J, Loren A, MacMilan M, Martinez C, Davies SM, Pasquini MC. Pulmonary Complications in Pediatric and Adolescent Patients Following Allogeneic Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2019. Doi:10.1016/j.bbmt.2019.06.004
10. Broglie L*, Thakar MS*, Logan B, Artz A, Bunin N, Burroughs LM, Fretham C, Jacobsohn DA, Loren AW, Kurtzberg J, Martinez CA, Mineishi S, Nelson AS, Woolfrey A, Pasquini MC, Sorror ML. The Hematopoietic Cell Transplant Comorbidity Index Predicts Survival After Allogeneic Transplant for Non-Malignant Diseases. Blood. 2019; 133(7): 754-762. doi: blood-2018-09-876284 (co-first author)
11. Lund TC, Ahn KW, Tecca HR, Hilgers MV, Abdel-Azim H, Abraham A, Diaz MA, Badawy SM, Broglie L, Brown V, Dvorak CC, Gonzalez-Vicent M, Hashem H, Hayashi RJ, Jacobsohn DA, Kent MW, Li CK, Margossian SP, Martin PL, Mehta P, Myers K, Olsson R, Page K, Pulsipher MA, Shaw PJ, Smith AR, Triplett BM, Verneris MR, Eapen M. Outcomes After Second Hematopoietic Cell Transplant for Children and Young Adults with Relapsed Acute Leukemia. Biol Blood Marrow Transplant. 2019; 25(2): 301-306. doi: 10.1016/j.bbmt.2018.09.016
12. Hu L, Huang W, Bei L, Broglie L, Eklund EA. TP53 Haploinsufficiency Rescues Emergency Granulopoiesis in FANCC-/- Mice. J Immunol. 2018; 200(6): 2129-2139. doi: 10.4049/jimmunol.1700931
13. Shah, CA*, Broglie L*, Hu L, Huang W, Dressler DB, Eklund EA. Stat3 and the CCAAT-enhancer binding protein β (C/ebpβ) activate Fanconi C gene transcription during emergency granulopoiesis. J Biol Chem. 2018; 293(11): 3937-3948. doi: 10.1074/jbc.RA117.000528
14. Broglie L, Rademaker A, Galvin J, Ray A, Tse W, Duerst R, Schneiderman J, Kletzel M, Chaudhury S. Fecal Calprotectin and Albumin as Markers of Gastrointestinal Graft Versus Host Disease. Hematol Oncol Stem Cell Ther. 2018;11(3): 169-174. Doi: 10.1016/j.hemonc.2017.12.003
15. Broglie L, Helenowski I, Jennings LJ, Schafernak K, Duerst R, Schneiderman J, Tse W, Kletzel M, Chaudhury S. Early Mixed T-cell Chimerism is Predictive of Pediatric AML or MDS Relapse after Hematopoietic Stem Cell Transplant. Pediatr Blood Cancer. 2017; 64(9). doi: 10.1002/pbc.26493
16. Broglie L, Hijiya N, Helenowski IB, Dilley K, Schneiderman J, Tse W, Duerst R, Kletzel M, Morgan E, Chaudhury S. Long-Term Follow-up of Children with Chronic Myeloid Leukemia after Hematopoietic Stem Cell Transplant and Tyrosine Kinase Inhibitor Therapy. Leuk Lymphoma. 2016; 57(4):949-952. doi: 10.3109/10428194.2015.1065981
17. Chani Traube, Linda M Gerber, Elizabeth A Mauer, Keshia Small, Larisa Broglie, Yogi Raj Chopra, Christine Noel Duncan, Christen L Ebens, Julie Fitzgerald, Jason L Freedman, Michelle P Hudspeth, Caitlin Hurley, Kris Michael Mahadeo, Jennifer Ann McArthur, Miriam C Shapiro, Matthew P Sharron, Donna Wall, Matt S Zinter, Bruce M Greenwald, Gabrielle Silver, Farid Boulad. Delirium in Children Undergoing Hematopoietic Cell Transplantation: a multi-institutional point prevalence study. Frontiers in Oncology, section Pediatric Oncology Article type: Original Research. 2021 In Press.
18. Broglie L*, Taraseviciute A*, Phelan R, Bhatt N, Becktell K, Burke M. What is the Role of Hematopoietic Cell Transplantation (HCT) for Pediatric Acute Lymphoblastic Leukemia (ALL) in the Age of Chimeric Antigen Receptor T-Cell (CART) Therapy? J Pediatr Hematol Oncol. 2019; 41(5): 337-344. doi: 10.1097/MPH.0000000000001479. PMID: 30973486(co-first author)
19. Broglie L, Margolis D, Medin JA. Yin and Yang of Mesenchymal Stem Cells and Aplastic Anemia. World J Stem Cells. 2017; 9(12): 219-226. doi: 10.4252/wjsc.v9.i12.219