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CURRICULUM VITAE

Lawrence M. Ryan MD
Emeritus Professor
Department of Medicine
Division of Medicine Rheumatology

OFFICE ADDRESS:
8850 William Coffey Drive
Milwaukee, WI 53226

EDUCATION:
09/1967 - 05/1971 M.D. (Cum Laude), Loyola University, Stritch School of Medicine, Chicago, IL

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
1971 - 1974 Medical Resident, Medical College of Wisconsin, Milwaukee, WI
1974 - 1975 Chief Medical Resident, Medical College of Wisconsin, Milwaukee, WI
1975 - 1977 Fellow in Rheumatology, Medical College of Wisconsin, Milwaukee, WI
1978 - 1981 Postdoctoral Research Fellow, National Arthritis Foundation, Medical College of Wisconsin, Milwaukee, WI

MILITARY SERVICE:
1972 - 1978 U.S. Army Reserve Medical Corps

FACULTY APPOINTMENTS:
1977 - 1983 Assistant Professor of Medicine, Medical College of Wisconsin, Milwaukee, WI
1983 - 1989 Associate Professor of Medicine, Medical College of Wisconsin, Milwaukee, WI
1989 - Present Professor of Medicine, Medical College of Wisconsin, Milwaukee, WI
1997 - Present Will and Cava Ross Professor of Medicine, Medical College of Wisconsin, Milwaukee, WI

ADMINISTRATIVE APPOINTMENTS:
1987 - 1989 Co Chief, Division of Rheumatology, Medical College of Wisconsin, Milwaukee, WI
1988 - Present Director, Rheumatology Diagnostic Laboratory, Medical College of Wisconsin, Milwaukee, WI
1989 - 2010 Chief, Division of Rheumatology, Medical College of Wisconsin, Milwaukee, WI
2005 - 2010 Medical Director, Rheumatology Clinic, Medical College of Wisconsin, Milwaukee, WI

EDUCATIONAL ADMINISTRATIVE APPOINTMENTS:
1988 - 1989 Director, Rheumatology Fellowship, Medical College of Wisconsin, Milwaukee, WI
1998 - 2000 Director, Rheumatology Fellowship, Medical College of Wisconsin, Milwaukee, WI

HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS:
2005 - 2010 Medical Director, Rheumatology Clinic, MCW, Milwaukee, WI

HOSPITAL STAFF PRIVILEGES:
1977 - Present Attending, Zablocki VAH, Milwaukee, WI
1985 Senior Attending, Froedtert Memorial Lutheran Hospital, Milwaukee, WI

SPECIALTY BOARDS AND CERTIFICATION:
Board Certified
Issue DateExpiration
American Board of Internal Medicine
1975
None
ABIM-Rheumatology
1978
None
   
Licensure
Number Issue DateExpiration
Wisconsin
18925
10/31/2005
    

AWARDS AND HONORS:
1964 - 1967 Loyola University Dean's List - all semesters
1964 - Present Loyola University Scholar, Closed
1964 - Present Loyola University Scholar, Open
1964 - Present Cardinal Stritch Scholar
1964 - Present National Merit Scholar
1964 - Present Illinois State Scholar
1967 - 1971 cum laude graduate, Loyola University, Stritch School of Medicine
1967 - Present Phi Sigma Tau National Philosophical Honor Society
1972 - Present Resident of the Year Award, Medical College of Wisconsin
1978 - 1981 Postdoctoral Research Fellowship, National Arthritis Foundation
1982 - Present Fellow, American College of Physicians
1982 - 1985 New Investigator Award NIH, NIADDKD
1986 - 1991 Research Career Development Award NIH, NIAMSD
1988 - Present Teaching Recognition Award , Department of Physical Medicine and Rehab, Medical College of Wisconsin
1989 - Present Robert Doucette Prize in Research, Wisconsin Chapter Arthritis Foundation
1992 - Present Excellence in Attending Award, Department of Medicine, Medical College of Wisconsin
1993 - Present Teaching Scholar, Medical College of Wisconsin
1994 - 2010 Best Doctors in America
1996 - Present Best Doctors, Milwaukee
1998 - Present Distinguished Service Award, Medical College of Wisconsin
1998 - Present Excellence in Teaching Award, Department of Medicine, Medical College of Wisconsin
2000 - Present Best Teacher,Department of Medicine 1999-2000, Medical College of Wisconsin
2004 - Present Resident Teaching Award, Department of Medicine, Medical College of Wisconsin
2005 - Present Resident Teaching Award, Department of Medicine, Medical College of Wisconsin
2006 - Present Resident Teaching Award, Department of Medicine, Medical College of Wisconsin
2007 - 2008 Finalist (1 of 5), Best Outpatient Teacher, Dept of Med
2007 - 2010 Top Ten Patient Outpatient Providers Satisfaction Ranking, Froedtert Hospital
2009 - Present Best Outpatient Resident Teaching Service
2010 - Present Best Outpatient Resident Teaching Service
2011 - Present Finalist 91 OF 5), Best Outpatient Teacher, Dept of Med

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
American Association for the Advancement of Science
American College of Physicians (Fellow)
American College of Rheumatology (Fellow)
American Federation for Clinical Research
American Medical Soccer Association
Arthritis Foundation
Wisconsin Rheumatism Society
Central Society for Clinical Research
Foundation for Medical Care Evaluation of Southeastern Wisconsin
Orthopaedic Research Society
Osteoarthritis Research Society
Society for Experimental Biology & Medicine
Society of Teaching Scholars (MCW)
Central Rheumatism Society

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorship
2002 Crystal Deposition Diseases
2002 Current Opinion in Rheumatology
Editorial Board
1985 - 1988 Arthritis and Rheumatism
Journal Review
1985 - 1988 Journal of Rheumatology
1985 - 1988 Journal of the American Medical Association
1985 - 1988 Molecular and Cellular Biology
1985 - 1988 Osteoarthritis and Cartilage Science
1985 - 1988 Journal of Cellular Biology
1985 - 1988 Journal Lab Clin Med
1985 - 1988 Journal of Musculoskeletal Medicine
1985 - 1988 Breast Cancer Research and Treatment
1985 - 1988 Journal of Bone and Mineral Research
1985 - 1988 American Journal of Human Genetics

LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
1981 - 1985 Medical and Scientific Committee, Arthritis Foundation, Wisconsin Chapter
1982 - 1984 Chairman, Research Subcommittee, Medical and Scientific Committee, Arthritis Foundation Wisconsin Chapter
1986 - 1988 Government Affairs Committee, Arthritis Foundation, Wisconsin Chapter
1989 - 1990 Chairman, Research Subcommittee, Medical and Scientific Committee, Arthritis Foundation, Wisconsin Chapter
1992 - 1995 Chairman, Patient Information Education Committee, Arthritis Foundation, Wisconsin Chapter
1993 - 1995 Medical and Scientific Committee, Arthritis Foundation, Wisconsin Chapter
1995 - 2004 Board of Directors, Arthritis Foundation, Wisconsin Chapter
1996 - 2000 Vice President Programs, Arthritis Foundation, Wisconsin Chapter
1996 - 1999 Chairman, Medical and Scientific Committee, Arthritis Foundation, Wisconsin Chapter

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
1980 Program Committee, Scientific Sessions, 44th Annual Meeting, American Rheumatism Association, Atlanta, GA
1984 Program Committee, Scientific Sessions, 48th Annual Meeting, American Rheumatism Association, Minneapolis, MN
1984 Section Chairman, Prevention Conference on Arthritis, National Advisory Board and National Institutes of Arthritis, Diabetes and Digestive and Kidney Diseases (NIH) and the Department of Defense
1985 Program Committee, Scientific Sessions, 49th Annual Meeting, American Rheumatism Association, Anaheim, CA
1986 Program Committee, Scientific Sessions, 50th Annual Meeting, American Rheumatism Association, New Orleans, LA
1986 - 1987 National Arthritis Foundation, Chapter Research Grants Subcommittees
1986 Chairman, Rheumatology Section, Central Society for Clinical Research
1987 Abstract Selection Group, Scientific Sessions, 51st Annual Meeting, American Rheumatism Association (Chairman, Osteoarthritis Section)
1987 Program Chairman, Immunology Rheumatology Section, Midwest Meeting, American Federation for Clinical Research
1987 Chairman, Rheumatology Program Committee, Central Society for Clinical Research
1987 Program Committee, Central Regional American Rheumatism Association Meeting
1988 Site Visit Team, National Institute on Aging
1988 Grants Subcommittee National Arthritis Foundation
1989 Co chairman, Immunology, Rheumatology Section, Central Society for Clinical Research
1990 Abstract Selection Group, American College of Rheumatology
1992 National Institutes of Health, ad hoc Reviewer, Clinical Sciences Subcommittee
1992 Veterans Administration Research Services, External Reviewer
1992 Abstract Selection Committee, American College of Rheumatology (Chairman, Bone and Cartilage, Osteoarthritis, Orthopedics, and Soft Tissue Sections)
1992 - 1994 Cell Biology Section, Grants Subcommittee National Arthritis Foundation
1993 Reviewer, Medical Research Council of Canada
1994 National Institutes of Health, ad hoc Reviewer, Small Business Grants
1995 Abstract Selection Committee, American College of Rheumatology
1995 Study Section "New Horizons in Osteoarthritis Research, " National Institutes of Health, NIAMDS and NIA
1996 Abstract Selection Committee, American College of Rheumatology
1998 Veterans Administration Research Services, External Reviewer
2000 Abstract Selection Committee, American College of Rheumatology
2001 Special Emphasis Panel, National Institutes of Health, GMA1
2003 Reviewer, Wellcome Trust, UK Physiology and Pharmacology)
2005 NIAMS MCRC P60 Review Meeting National Institutes of Health
2006 Abstract Selection Committee, American College of Rheumatology
2007 NIAMS Special emphasis review panel ZRG-1 MOSS-C, ACTS National Institutes of Health

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Non-Peer Review
Title:
“Is there an association between hypovitaminosis D and chondrocalcinosis?”
Source:
Froedtert Friends Grant
Role & Effort:
Principal Investigator
Dates:
04/2009 - Present
Direct Funds:
$3,500
  
Prior
Peer Review
Title:
"Studies in crystal deposition disease"
Source:
National Institutes of Health RO-1
Role & Effort:
Fellow and Staff Investigator
Dates:
02/01/1977 - 01/31/1982
Direct Funds:
$298,337
  
Title:
"An arthritis center for Southeastern Wisconsin"
Source:
National Institute of Arthritis Metabolism and Digestive Diseases
Role & Effort:
Staff Investigator
Dates:
10/01/1978 - 09/30/1981
Direct Funds:
$450,000
  
Title:
"Pyrophosphate metabolism in health and disease"
Source:
Postdoctoral Fellowship, National Arthritis Foundation
Dates:
1978 - 1981
Direct Funds:
$46,500
  
Title:
"Studies of particulate matter in synovial fluid"
Source:
National Institutes of Health RO-1
Role & Effort:
Staff Investigator
Dates:
07/01/1979 - 06/30/1982
Direct Funds:
$572,867
  
Title:
"Fibroblast stimulation in progressive systemic sclerosis"
Source:
Arthritis Foundation, Wisconsin Chapter
Role & Effort:
Principal Investigator
Dates:
1979 - 1980
Direct Funds:
$2,500
  
Title:
"Arthritis Clinical Research Center Grant"
Source:
National Arthritis Foundation
Role & Effort:
Staff Investigator
Dates:
07/01/1980 - 06/30/1981
Direct Funds:
$25,000
  
Title:
"Clearance of 85Sr, 45Ca, calcium pyrophosphate dihydrate crystals in vivo and by synovial cells in tissue culture"
Source:
Kroc Foundation
Role & Effort:
Investigator
Dates:
08/1980 - 04/1981
Direct Funds:
$50,500
  
Title:
"Alkaline phosphatase and pyrophosphatase activities of red cells in patients with osteoarthritis and chondrocalcinosis"
Source:
Arthritis Foundation, Wisconsin Chapter
Role & Effort:
Principal Investigator
Dates:
1980 - 1981
Direct Funds:
$4,000
  
Source:
Institutional Research Committee Medical College of Wisconsin
Role & Effort:
Principal Investigator
Dates:
1980 - 1981
Direct Funds:
$3,000
  
Title:
"Ecto pyrophosphohydrolase as pyrophosphate generator in cartilage"
Source:
Arthritis Foundation, Wisconsin Chapter
Role & Effort:
Principal Investigator
Dates:
01/01/1982 - 12/31/1982
Direct Funds:
$4,000
  
Title:
"Studies in crystal deposition disease"
Source:
National Institutes of Health RO-1
Role & Effort:
Co Investigator
Dates:
02/1982 - 03/1987
Direct Funds:
$980,000
  
Title:
"Pyrophosphate metabolism in health and disease"
Source:
National Institute of Arthritis, Diabetes and Kidney Diseases
Role & Effort:
New Investigator Award
Dates:
11/1982 - 10/1985
Direct Funds:
$99,000
  
Title:
"Inorganic pyrophosphate metabolism in human synovial fluid"
Source:
Arthritis Foundation, Wisconsin Chapter
Role & Effort:
Co Principal Investigator
Dates:
11/01/1984 - 12/31/1984
Direct Funds:
$6,000
  
Title:
"Nucleoside triphosphate pyrophosphohydrolase in pyrophosphate metabolism of chondrocytes and articular cartilage"
Source:
Arthritis Foundation, Wisconsin Chapter
Role & Effort:
Co Principal Investigator
Dates:
11/01/1985 - 12/31/1985
Direct Funds:
$7,000
  
Title:
"Pyrophosphate metabolism in arthritis"
Source:
National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Role & Effort:
Research Career Development Award
Dates:
09/1986 - 08/1991
Direct Funds:
$250,000
  
Title:
"Inorganic pyrophosphate metabolism in arthritis"
Source:
National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Dates:
05/01/1987 - 04/30/1992
Direct Funds:
$432,000 (direct costs)
  
Title:
"Biomedical Research Center Grant"
Source:
National Arthritis Foundation
Role & Effort:
Principal Investigator
Dates:
07/1988 - 06/1990
Direct Funds:
$92,500 (direct costs )
  
Title:
"Augmentation of inorganic pyrophosphate elaboration in cartilage explants by serum factors"
Source:
National Arthritis Foundation, Wisconsin Chapter
Role & Effort:
Co Principal Investigator
Dates:
1989
Direct Funds:
$7,500
  
Title:
"Inorganic pyrophosphate metabolism in arthritis"
Source:
National Institutes of Health, NIAMSD
Role & Effort:
Principal Investigator
Dates:
09/01/1992 - 08/31/1996
Direct Funds:
$680,000 (direct costs )
  
Title:
Summer Medical Student Fellowship
Source:
American College of Rheumatology
Role & Effort:
Sponsor
Dates:
1993
Direct Funds:
$3,000
  
Title:
"Inorganic pyrophosphate metabolism in arthritis"
Source:
National Institutes of Health, NIAMSD
Role & Effort:
Principal Investigator
Dates:
09/01/1996 - 08/31/2000
Direct Funds:
$780,000 (direct costs)
  
Title:
"Inorganic pyrophosphate metabolism"
Source:
Research Affairs Committee, Medical College of Wisconsin
Role & Effort:
Principal Investigator
Dates:
1996 - 1997
Direct Funds:
$10,000
  
Title:
Mentored Scientist Award, Joseph Barbieri, PhD
Source:
Arthritis Foundation, Wisconsin Chapter
Role & Effort:
Sponsor
Dates:
05/2000 - 04/2001
Direct Funds:
$25,000 (direct costs)
  
Title:
“Inorganic pyrophosphate metabolism in arthritis”
Source:
Research Affairs Committee Award Medical College of Wisconsin
Role & Effort:
Principal Investigator
Dates:
06/15/2000 - 06/14/2001
Direct Funds:
$15,000 (direct costs)
  
Title:
“Inorganic pyrophosphate metabolism in arthritis”
Source:
National Institutes of Health, NIAMSD
Dates:
04/19/2002 - 03/31/2007
Direct Funds:
$910,000 (direct costs)
  
Non-Peer Review
Title:
START program
Source:
Pfizer
Role & Effort:
Principal Investigator
Dates:
1995 - 1996
Direct Funds:
$21,000
  
Title:
"Cloning of the human 127 kD NTPPPH Gene"
Source:
Pfizer Central Research
Role & Effort:
Principal Investigator
Dates:
07/01/1996 - 06/30/1997
Direct Funds:
$53,350 (direct costs)
  
Title:
"Nucleoside triphosphate pyrophosphohydrolase"
Source:
Pfizer Central Research
Role & Effort:
Principal Investigator
Dates:
11/1997 - 10/1998
Direct Funds:
$67,000 (direct costs)
  
Title:
Screen the Human ANK Gene for Novel Variants Associated with Crystal Deposition and Osteoarthritis
Source:
Pfizer Central Research
Role & Effort:
Prinicpal Investigator
PI:
85000
Dates:
02/2002 - 01/2003
  
Title:
PC-1 Inhibitors and Pyrophosphate Metabolism
Source:
Pfizer Central Research
Role & Effort:
Prinicpal Investigator
Dates:
08/2004 - 07/2005
Direct Funds:
$78,000
  

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
International
"Strategies for Evolving Therapies in Calcium Pyrophosphate Crystal Deposition Disease" Crystal Club - American College of Rheumatology, Orlando, FL, 10/1996 - Present
"Pyrophosphate Crystal Deposition and Osteoarthritis" Pfizer Central Research St. Louis, MO simulcast London, England, 11/14/2003 - Present
Invited commentator "Is ANK the Answer?" Opening Plenary Session American College of Rheumatology San Antonio, TX, 10/18/2004 - Present
 
National
Advances in Rheumatology, Mountain Area Health Education Center, Asheville, NC. University of North Carolina, Chapel Hill "The spondyloarthritides", 05/21/1986 - Present
Meet the Professor "Crystal Arthritis", American College of Rheumatology, Atlanta, GA, 10/14/1992 - 10/15/1992
"Role of Matrix Vesicles in Chondrocalcinosis" Crystal Club American College of Rheumatology, Atlanta, GA, 10/1992 - Present
Meet the Professor "Crystal Arthritis", American College of Rheumatology, San Antonio, TX, 11/1993 - Present
"Inorganic Pyrophosphate Metabolism" Pfizer Research, Groton, CN, 10/1994 - Present
Visiting Professor Mayo Clinic and Research Foundation Rochester, MN, 10/30/1996 - 11/01/1996
"CPPD Crystal Deposition Disease", Pfizer Central Research, Groton, CT, 11/03/1996 - 11/04/1996
Hyaluronan: A new approach to an old disease Washington, D.C., 11/21/1997 - Present
"Calcium Pyrophosphate Deposition and Arthritis", Grand Rounds, University of Miami School of Medicine, Miami, FL, 12/03/1997 - Present
Arthritis and GRECC Scientific Meeting University of Miami School of Medicine, Miami VAH Miami, FL "Calcium Pyrophosphate Deposition Mechanisms: Ectoenzymes, Vesicles, and Signal Transduction", 12/04/1997 - Present
Greenville, NC "Clinical Problems in Rheumatoid Arthritis", 02/20/1998 - Present
"Current Issues in Osteoarthritis", Grand Rounds, East Carolina University School of Medicine, Grand Rounds, East Carolina University School of Medicine, 02/20/1998 - Present
University of Chicago Pritzker School of Medicine Chicagoland Rheumatology Fellows Lecture Series "Arthritis Associated with Calcium-containing Crystals" Chicago, IL, 10/20/2001 - Present
"Pyrophosphate Metabolism" Crystal Study Group American College of Rheumatology San Francisco, CA, 11/13/2001 - Present
“CPPD Crystal Deposition Disease”, U of Illinois, Chicago, Chicago, IL, 09/14/2003 - Present
"Pyrophosphate Metabolism and CPPD Crystal Deposition" University of Chicago, Rheumatology Division Chicago, IL, 11/11/2003 - Present
"Pyrophosphate Metabolism and Chondrocalcinosis" Chicagoland Fellows' Basic Science Conference Northwestern University, sponsor, 11/06/2005 - Present
"Calcium Containing Crystals: Basic Science Aspects", Chicago Area Fellows' Basic Science Conference, (U of I-C, Rush, U of C, Loyola, Northwestern), 11/17/2007 - Present
"Calcium Crystal Deposition Arthropathies" American College of Rheumatology Annual Review Course Philadelphia, PA, 10/17/2009 - Present
"Inorganic Pyrophosphate Metabolism" American College of Rheumatology Crystal Study Group Philadelphia, PA, 10/20/2009 - Present
"CPPD Crystals and Inorganic Pyrophosphate Metabolism" Chicago Area Fellows' Basic Science Course Northwestern University (University of Chicago sponsoring) Chicago, IL, 12/19/2009 - Present
 
Regional
"Ecto pyrophosphohydrolase as a pyrophosphate generator in cartilage" Annual Meeting of Wisconsin Rheumatism Association, Pfister Hotel, Milwaukee, WI, 05/07/1983 - Present
"Middle aged man with syncope and hemoptysis", Clinical Pathological Conference, Milwaukee County Medical Complex, 02/27/1984 - Present
"Nonsteroidal anti inflammatory drugs" and "Osteoarthritis", Conservative Management of Chronic Pain, Department of Anesthesiology, Medical College of Wisconsin, Kohler, WI, 05/02/1986 - 05/04/1986
Rheumatology Research Update: Internal Medicine Egg Harbor, Wisconsin, 11/1991 - Present
"Crystals and Arthritis" Grand Rounds, Gunderson Clinic and Medical Foundation LaCrosse, WI, 10/27/1997 - Present
 
Local
Keynote Speaker, Annual Meeting of Arthritis Foundation, Wisconsin Chapter, Pfister Hotel, Milwaukee, WI, 05/07/1983 - Present
"Crystal induced arthritis" March 5, Medical Staff Meeting, Elmbrook Memorial Hospital, Brookfield, WI, 03/05/1984 - Present
"Ethical Considerations in rheumatic disease research", Arthritis Health Professionals Seminar, Pfister Hotel, Milwaukee, WI, 1985 - Present
Medical Grand Rounds, Medical College of Wisconsin, Clinical Research, 08/1988 - Present
Workshop in Molecular Biology Bethesda Research Laboratories, 11/1988 - Present
Medical Grand Rounds Medical College of Wisconsin, 11/1990 - Present
Clinical Pathological Conference Zablocki VA Hospital, 08/1994 - Present
CPC, St. Joseph's Hospital, Milwaukee, WI, 05/1996 - Present
Grand Rounds, Froedtert Memorial Lutheran Hospital, 08/01/1997 - Present
Medical Scientist Training Program student forum, 10/20/1999 - Present
Specialized Care and Procedures for the Geriatric Patient, MCW "Practical Approaches to the Management of Osteoarthritis" "Joint Injection: Tips and Tricks", 11/13/1999 - Present
Symposium for Retired Physicians, MCW "New Treatments for Arthritis", 10/10/2000 - Present
Department of Medicine Research Day, MCW "Adenylyl Cyclase Inhibits Chondrocyte Pyrophosphate Elaboration", 10/20/2000 - Present
CPC Department of Medicine Medical College of Wisconsin, 05/03/2011 - 05/05/2011
 

COMMITTEE SERVICE:
Medical College of Wisconsin
1981 - 1982 Chairman, Human Research Review Committee
1985 - 1988 Neurology Chairman Search Committee
1986 Department of Medicine Annual Report Committee
1987 - 1988 Five Year Review Committee, Dept. of Physical Medicine & Rehabilitation
1987 - 1997 Chairman, ad hoc Committee on Rank & Tenure, Department of Medicine
1989 - 2010 Executive Committee, Department of Medicine
1991 - 1994 Physical Medical & Rehabilitation Chairman Search Committee
1994 Incentive Planning Group, Department of Medicine
1994 - 1995 Subcommittee on Pricing and Fees
1995 - 2010 Residency Curriculum Committee, Department of Medicine
1995 - 1996 Physical Medicine & Rehabilitation Chairman Search Committee
1995 Ad hoc Dean's Committee on Rank and Tenure
1995 - 2001 Sabbatical Committee
1996 Appeals Committee, Academic Standing Committee
1997 - 2000 Rank and Tenure Committee
1997 - 2001 Faculty Development Committee, Department of Medicine
1997 - 1999 Research Honors Committee
1997 - 2001 Chairman, Sabbatical Committee
1999 - 2010 Orthopaedic and Rehabilitation Engineering Center Board of Advisors, MCW/Marquette
1999 - 2000 Elected department liaison, Search Committee for Chairman, Department of Medicine
2000 - 2001 Medical Scientist Training Program Curriculum Revision Committee
2000 Search Committee for Administrator, Department of Medicine
2001 - 2002 Chairman, Physical Medicine and Rehabilitation Chair Search Committee
2001 Abstractor Group, Department of Medicine
2002 - Present Faculty Development Committee, Department of Medicine
2003 United Way Coordinator, Department of Medicine
2003 Pediatric Allergy Immunology Chief Search Committee
2004 - 2009 Chairman, Faculty Development Committee, Department of Medicine
2005 - 2010 Ambulatory Working Group, Department of Medicine
 

MCW TEACHING ACTIVITIES:
Medical Student Education
1977 - 2007 Senior Medical Students Ward Rounds, Preceptor, Master Clinician rotation, Preceptor, Scientific Basis of Medicine rotation
1977 - 2007 Junior Students Ward Rounds
1993 - 2006 Freshman/Sophomore Students Pathology Course Lectures
1995 - 2008 Freshman/Sophomore Students Biochemistry Course Lectures
1995 - 2006 Freshman/Sophomore Students Introduction to Clinical Exam
2009 - Present Junior Students Evaluation of Arthritis
2009 - Present Junior Students Case discussion
2011 - Present Freshman/Sophomore Students CER Course
 
Resident and Fellow Education
1977 - 2007 Ward Rounds, Rheumatology Consult Staffing, Rheumatology Conferences
1985 - 2007 Clinical review Mentor laboratory
2000 - Present Morning Report (Became Noon Report)
Orthopedic Rheumatology Conference
 

EXTRAMURAL TEACHING:
Resident and Fellow Education
1982 - 1985 NIH, Rheumatology Clinics and Consultant Staffing New Investigator
1985 - 1988 Arthritis Foundation , Postdoctoral Fellow
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
Postdoctoral Researchers
1989 - 1992 Beth Derfus, M.D., Physician Scientist Award American College of Rheumatology, 1992 95
1995 - 2000 Geraldine McCarthy, M.D., Clinical Investigator Award, National Institutes of Health
 
Clinical/Research Fellows
1981 - 1982 Michael P. Lynch, M.D., Wellcome Travelling Fellow
1987 - 1989 Ann Rosenthal,M.D., Arthritis Foundation 1989 92
1992 - 1993 Umit Olmez, M.D., University of Ankara
1996 - 1997 Ikuko Masuda, M.D., Ph.D., Pfizer Central Research Award; FIRST Award, NIAMSD
08/2003 - 09/2003 Aylin Sepici, PhD, Visiting Scientist, Ankara, Turkey
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Riley A, Ryan LM, Roth D: Renal proximal tubular dysfunction and paroxysmal nocturnal hemoglobinuria. Amer J Med 62:125 129, 1977
2. Kozin F, Haughton V, Ryan LM: The reflex sympathetic dystrophy syndrome in a child. J. Pediatrics 90:417 419, 1977
3. Ryan LM, Kozin F, Eiferman R: Immune complex uveitis. Ann Intern Med 88:62 63, 1978
4. Kozin F, Duquesnoy R, Rodey GE, Lightfoot RW Jr, Ryan LM: HLA typing in arthritis: Value in differential diagnosis and high prevalence of HLA CW1 and CW2 antigens in spondyloarthritis. Arthritis Rheum 21:889 895, 1978
5. Halverson PB, Kozin F, Ryan LM, Sulaiman AR: Rhabdomyolysis and renal failure in hypothyroidism. Ann Intern Med 91:57 58, 1979
6. Ryan LM, Kozin F, McCarty DJ: Quantification of human plasma inorganic pyrophosphate. I. Normal values in osteoarthritis and calcium pyrophosphate dihydrate crystal deposition disease. Arthritis Rheum 22:886 891, 1979
7. Ryan LM, Kozin F, McCarty DJ: Quantification of human plasma inorganic pyrophosphate. II. Biological variables. Arthritis Rheum 22:892 895, 1979
8. Cheung HS, Ryan LM, Kozin F, McCarty DJ: Identification of collagen subtypes in synovial fluid from arthritic patients. Amer J Med 68:325 331, 1980
9. Mackel S, Kozin F, Ryan LM, Jordon R: Concurrent linear scleroderma and systemic lupus erythematosus: A report of two cases. Investigative Derm 73:368 372, 1979
10. Cheung HS, Ryan LM, Kozin F, McCarty DJ: Synovial origins of rice bodies in joint fluid. Arthritis Rheum 23:72 76, 1980
11. Carrera GF, Foley WD, Kozin F, Ryan LM, Lawson TL: Computed tomography in sacroiliitis. Amer J Roentgenol 136:41 46, 1981
12. Cheung HS, Ryan LM: A method for determining DNA and chondrocyte content of articular cartilage. Analytical Biochemistry 116:93 97, 1981
13. Kozin F, Soin JS, Ryan LM, Carrera GF, Wortmann RL: Bone scintigraphy in the reflex sympathetic dystrophy syndrome: A potentially valuable diagnostic and therapeutic study. Radiology 138:437 443, 1981
14. Kozin F, Ryan LM, Carrera GF, Soin JS, Wortmann RL: The reflex sympathetic dystrophy syndrome. III. Scintigraphic studies, further evidence for the therapeutic efficacy of systemic corticosteroids and proposed diagnostic criteria. Amer J Med 70:23 30, 1981
15. Kozin F, Carrera GF, Ryan LM, Foley WD, Lawson TL: Computed tomography in the diagnosis of sacroiliitis. Arthritis Rheum 24:1479 1485, 1981
16. Ryan LM, Cheung HS, McCarty DJ: Release of pyrophosphate by mammalian articular hyaline and fibrocartilage in organ culture. Arthritis Rheum 24:1522 1527, 1981
17. Ryan LM, Cheung HS, Schwab JP, Johnson RP: Predominance of type II collagen in synovial chondromatosis. Clin Orthopedics and Related Research 168:171 175, 1982
18. Ryan LM, Liang G, Kozin F: Amyloid arthropathy: Possible association with chondrocalcinosis. J Rheumatol 9:273 278, 1982
19. Whyte MP, Valdez R, Ryan LM: Infantile hypophosphatasia: Enzyme replacement therapy by intravenous infusion of alkaline phosphatase rich plasma from patients with Paget's bone disease. J Pediatrics 101:379 386, 1982
20. Ryan LM, Carrera GF, Kozin F, Lightfoot RW Jr: A radiographic approach to the diagnosis of sacroiliitis. Arthritis Rheum 26:760 763, 1983
21. Ryan LM, Lynch MP, McCarty DJ: Inorganic pyrophosphate levels in blood platelets from normal donors and patients with calcium pyrophosphate dihydrate crystal deposition disease. Arthritis Rheum 26:564 566, 1983
22. Wortmann RL, Ryan LM: Biological variation of rabbit chondrocyte 5'nucleotidase. Proc Soc Exp Biol Med 173:349 354, 1983
23. Ryan LM, Wortmann RL, Karas BJ, McCarty DJ: Cartilage nucleoside triphosphate (NTP) pyrophosphohydrolase. I. Identification as an ectoenzyme. Arthritis Rheum 27:404 409, 1984
24. Ebright JR, Ryan LM: Acute erosive reactive arthritis associated with Campylobacter jejuni induced colitis. Amer J Med 76:321 323, 1984
25. Halverson PB, McCarty DJ, Cheung HS, Ryan LM: Milwaukee shoulder syndrome: Report of eleven additional cases with concomitant involvement of the knee in seven instances. Semin Arth Rheum 14:36 44, 1984
26. Ryan LM, Wortmann RL, Karas BJ, McCarty DJ: Cartilage nucleoside triphosphate pyrophosphohydrolase. II. Role in extracellular pyrophosphate generation and nucleotide metabolism. Arthritis Rheum 28:413-418, 1985
27. Rachow JW, Ryan LM: Adenosine triphosphate pyrophosphohydrolase and neutral inorganic pyrophosphatase in pathologic joint fluids: Elevated pyrophosphohydrolase in calcium pyrophosphate dihydrate deposition disease. Arthritis Rheum 28:1283 1288, 1985
28. Rachow JW, Ryan LM: Partial characterization of synovial fluid adenosine triphosphate pyrophosphohydrolase. Arthritis Rheum 28:1377 1383, 1985
29. Wortmann RL, Ryan LM, Karas B, McCarty DJ: Ecto nucleoside triphosphate pyrophosphohydrolase activity and calcium pyrophosphate dihydrate crystal deposition disease. Adv Exp Med and Biol 195A:153 156, 1986
30. Ryan LM, Wortmann RL, Karas B, Lynch MP, McCarty DJ: Pyrophosphohydrolase activity and inorganic pyrophosphate content of cultured human skin fibroblasts: Elevated levels in some patients with calcium pyrophosphate dihydrate deposition disease. J Clin Invest 77:1689 1693, 1986
31. Kneeland J, Carrera G, Middleton W, Campagna N, Ryan L, Jesmanowicz A, Funcisz W, Hyde J: Rotator cuff tears: preliminary application of high resolution MRI imaging with counter rotating current loop gap resonators. Radiology 160:695 699, 1986
32. Harris GJ, Franson TR, Ryan LM: Recurrent aseptic meningitis as a manifestation of mixed connective tissue disease: A case report. Wisconsin Med J 86:31 33, 1987
33. Rachow JW, Ryan LM, McCarty DJ, Halverson PB: Synovial fluid inorganic pyrophosphate concentration and nucleotide pyrophosphohydrolase activity in basic calcium phosphate deposition arthropathy and Milwaukee shoulder syndrome. Arthritis Rheum 31:408 413, 1988
34. Lohr KM, Ryan LM, Toohill RJ, Anderson T: Anterior pituitary involvement in Wegener's granulomatosis. J Rheumatol 15:855 857, 1988
35. Rosenthal A, Ryan LM, McCarty DJ: Arthritis associated with calcium oxalate crystals in an anephric patient treated with peritoneal dialysis. J Am Med Assoc 260:1280 1282, 1988
36. Halverson PB, Ryan LM: Triple crystal disease. Ann Rheum Dis 47:864 865, 1988
37. Kolan E, Hartz A, Rimm A, Ryan L, Jones R, Kirchdoerfer E: Factors associated with severity of symptoms in patients with chronic unexplained muscular aching. J Rheumatol 48:317 321, 1989
38. Ryan LM, Kurup I, Rosenthal AK, McCarty DJ: Stimulation of inorganic pyrophosphate elaboration by cultured cartilage and chondrocytes. Archives of Biochem Biophys 272:393 399, 1989
39. Rosenthal AK, Cheung HS, Ryan LM: Augmentation of inorganic pyrophosphate elaboration in cartilage by serum factors. Archives of Biochem Biophys 272:386 392, 1989
40. Wortmann RL, Veum JA, Ryan LM, Cheung HS: Differential deoxyadenosine toxicity to immature rabbit cartilage in vitro: A model for the chondro-osseous dysplasia of adenosine deaminase deficiency. Arthritis Rheum 32:1014 1021, 1989
41. Rosenthal AK, Cheung HS, Ryan LM: Stimulation of pyrophosphate production in articular cartilage is independent of mitogenesis. J Lab Clin Med 115:352 355, 1990
42. Ryan LM, Kurup I, McCarty DJ, Cheung HS: Cartilage inorganic pyrophosphate elaboration is independent of sulfated glycosaminoglycan synthesis. Arthritis Rheum 33:235 240, 1990
43. Ryan LM, Rachow JW, McCarty DJ: Synovial fluid ATP: A potential substrate for the production of inorganic pyrophosphate. J Rheumatol 18:716 720, 1991
44. Rosenthal AK, Cheung HS, Ryan LM: Transforming growth factor ß1 stimulates inorganic pyrophosphate elaboration by porcine cartilage. Arthritis Rheum 34:904 911, 1991
45. Ryan LM, Kurup I, Cheung HS: Stimulation of cartilage inorganic pyrophosphate elaboration by ascorbate. Matrix: Collagen and Related Res. 11:276 281, 1991
46. Derfus BA, Carrera GF, Komorowski RA, Ryan LM: Severe arthropathy and osteopathy following combined renal/pancreas transplantation. Transplantation 53:678 681, 1992
47. Derfus BA, Rachow JW, Mandel NS, Boskey AL, Buday M, Kushnaryov VM, Ryan LM: Articular cartilage vesicles generate calcium pyrophosphate dihydrate-like crystals in vitro. Arthritis Rheum 35:231 240, 1992
48. Ryan LM, Kurup I, Derfus BA, Kushnaryov VM: ATP induced chondrocalcinosis. Arthritis Rheum 35:1520 1525, 1992
49. McCarthy GM, Carrera GF, Ryan LM: Acute calcific periarthritis of the finger joints: A syndrome of women. J Rheumatol, 20:1077-1080, 1993
50. Fife RS, Kluve Beckerman B, Houser DS, Proctor C, Liepnieks J, Masuda I, McCarty DJ, Ryan LM: Evidence that a 550,000 dalton cartilage matrix glycoprotein is a chrondrocyte membrane associated protein closely related to ceruloplasmin. J Biol Chem 268:4407 4411, 1993
51. Rosenthal AK, McCarty BA, Cheung HS, Ryan LM: A comparison of the effect of transforming growth factor ß1 on pyrophosphate elaboration from various articular tissues. Arthritis Rheum 36:539 542, 1993
52. Fife RS, Rachow JW, Ryan LM: Synovial fluid and plasma levels of cartilage matrix glycoprotein in arthritis. Calcif Tissue Int 55:100-102, 1994
53. Olmez U, Ryan LM, Kurup IV, Rosenthal AK: Insulin-like growth factor-1 suppresses pyrophosphate elaboration by transforming growth factor ß1-stimulated chondrocytes and cartilage. Osteoarthritis and Cartilage 2:149-154, 1994
54. Rosenthal AK, Ryan LM: Probenecid inhibits the effect of TGFß1 on pyrophosphate elaboration by cartilage. J Rheumatol 21:896-900, 1994
55. Rosenthal AK, Ryan LM: Ageing influences TGFß-induced pyrophosphate elaboration by cartilage. Mech Ageing Devel 75:35-44, 1994
56. Masuda I, Hamada J, Haas AL, Ryan LM, McCarty DJ: A unique ectonucleotide pyrophos-phohydrolase associated with porcine chondrocyte derived vesicles. J Clin Invest 95:699-704, 1995
57. Whyte MP, Landt ML, Ryan LM, Mulivor RA, Henthorn PS, Fedde KN, Coburn SP: Alkaline phosphatase: Placental and tissue nonspecific isoenzymes hydrolyze phosphoethanolamine, inorganic pyrophosphate, and pyridoxal 5'-phosphate (substrate accumulation in carriers of hypophosphatasia corrects during pregnancy). J Clin Invest 95:1440-1445, 1995
58. Derfus B, Steinberg M, Mandel N, Buday M, Daft L, Ryan L: Characterization of an additional articular cartilage vesicle fraction that generates calcium pyrophosphate dihydrate crystals in vitro. J Rheumatol 22:1514-1519, 1995
59. Ryan LM, Rachow JW, McCarty BA, McCarty DJ: Adenosine triphosphate levels in human plasma. J Rheumatol 23:214-219, 1996
60. Cheung HS, Kurup IV, Sallis JD, Ryan LM: Inhibition of calcium pyrophosphate dihydrate crystal formation in articular cartilage vesicles and cartilage by phosphocitrate. J Biol Chem 271:28082-28085, 1996
61. Derfus BA, Kurtin SM, Camacho NP, Kurup I, Ryan LM: Comparison of matrix vesicles derived from normal and osteoarthritic human articular cartilage. Connective Tiss Res 35:337-342, 1996
62. Masuda I, Halligan BD, Barbieri JT, Haas AL, Ryan LM, McCarty DJ: Molecular cloning and expression of a porcine chondrocyte nucleotide pyrophosphohydrolase. Gene 197:277-287, 1997
63. Patel KJ, Weidensaul D, Palma C, Ryan LM, Walker SE: Milwaukee shoulder with massive bilateral cysts: Effective therapy for hydrops of the shoulder. J Rheumatol 24:2479-2483, 1997
64. McCarthy GM, Macius AM, Christopherson PA, Ryan LM, Pourmotabbed T: Basic calcium phosphate crystals induce synthesis and secretion of 92 kDa gelatinase (gelatinase B/matrix metalloprotease 9) in human fibroblasts. Ann Rheum Dis 57:56-60, 1998
65. McCarthy GM, Cheung HS, Abel SM, Ryan LM: Basic calcium phosphate crystal-induced collagenase production: Role of intracellular crystal dissolution. Osteoarthritis Cart 6:205-213, 1998
66. Derfus BA, Camacho NP, Olmez U, Westfall PR, Ryan LM, Rosenthal AK: Transforming growth factor 1 increases calcium pyrophosphate precipitation by articular chondrocyte matrix vesicles. Calcif Tissue Int 63:258-262, 1998
67. Cardenal A, Masuda I, Ono W, Haas AL, Ryan LM, Trotter D, McCarty DJ: Serum nucleotide pyrophosphohydrolase activity; Elevated levels in osteoarthritis, calcium Pyrophosphate crystal deposition disease, scleroderma, and fibromyalgia. J Rheumatol 25:2175-2180, 1998
68. Derfus B, Kranendonk S, Camacho N, Mandel N, Kushnaryov V, Lynch K, Ryan L: Human osteoarthritic cartilage matrix vesicles generate both calcium pyrophosphate dihydrate and apatite in vitro. Calcif Tissue Int 63:258-262, 1998
69. Ryan LM, Kurup IV, Cheung HS: Transduction mechanisms of porcine chondrocyte inorganic pyrophosphate elaboration. Arthritis Rheum 42:555-560, 1999
70. Cheung HS, Ryan LM: Phosphocitrate blocks nitric oxide-induced calcification of cartilage and chondrocyte-derived apoptotic bodies. Osteoarthritis Cart 7:409-412, 1999
71. Fedde KN, Blair L, Silverstein J, Coburn SP, Ryan LM,Weinstein RS, Waymire K, MacGregor GR, Narisawa S, Millan JL, Whyte MP: Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia. J Bone Miner Res 14:2015-2026, 1999
72. Ryan LM, Cheung HS, LeGeros RZ, Kurup IV, Toth J, Westfall PR, McCarthy GM: Cellular responses to whitlockite. Calcif Tissue Int 65:374-377, 1999
73. Derfus B, Camacho NP, Olmez U, Westfall PR, Ryan LM, Rosenthal AK: Transforming growth factor beta-1 stimulates articular chondrocyte elaboration of matrix vesicles capable of greater calcium pyrophosphate precipitation. Osteoarthritis Cart 9:189-194, 2001
74. Hirose J, Masuda I, Ryan LM: Expression of cartilage intermediate layer protein/nucleotide pyrophosphohydrolase (CILP/NTPPH) parallels the production of extracellular inorganic pyrophosphate in response to growth factors and with aging. Arthritis Rheum 43:2703-2711, 2000
75. Masuda I, Iyama K-I, Halligan BD. Barbieri JT, Haas AL, McCarty DJ, Ryan LM: Variations in site and levels of expression of chondroctye nucleotide pyrophosphohydrolase with aging. J Bone Miner Res 16:868-875, 2001
76. Derfus BA, Kurian JB, Butler JJ, Daft LJ, Carrera GF, Ryan LM, Rosenthal AK: The high prevalence of pathologic calcium crystals in pre-operative knees. J Rheumatol 29:570-574, 2002
77. Jaovisidha K, Hung J, Ning G, Ryan LM, Derfus BA: Comparative calcification of native articular cartilage matrix vesicles and nitroprusside-generated vesicles. Osteoarthritis Cart 10:646-652, 2002
78. Hirose J, Ryan LM, Masuda I: Up-regulated expression of cartilage intermediate layer protein (CILP) and ANK in calcium pyrophosphate dihydrate crystal deposition disease. Arthritis Rheum 46:3218-3217, 2002
79. Kurtzberg J, McAlister W, Mumm S, Podgornik M, Coburn S, Ryan L, Miller C, Gottesmann G, Smith A, Douville J, Wters-Pick B, Armstrong R, Martin P, Whyte MP: Marrow cell transplantation for infantile hypophosphatasia. J Bone Miner Res 18:624-636, 2003
80. Williams CJ, Pendelton A, Bonavita F, Reginato AJ, Hughes AE, Peariso S, Doherty M, McCarty DJ, Ryan LM: Mutations in ANKH in 2 US families with calcium pyrophosphate dihydrate deposition disease (CPPDD). Arthritis Rheum 48:2627-2631, 2003
81. Chan MR, Vasudev M, Piering WF, Ryan LM: Acute abdomen in a patient with systemic lupus erythematosus. Hospital Physician 41:27-31, 2005
82. van den Bos T, Handoko G, Niehof A, Ryan LM, Coburn SP, Whyte MP, Beersten W: Cementum and dentin in hypophosphatasia. J Dent Res. 84:1021-1025, 2005
83. Baumgartner-Sigl S, Haberlandt E, Mumm S, Scholl-Burgi S, Sergi C, Ryan L, Ericson KL, Whyte MP, Hogler W: Pyridoxine-responsive seizures as the first symptom of infantile hypophosphatasia caused by two novel missense mutations (c.677T>C; c.1112C>T, p. T371I) of the tissue-nonspecific alkaline phosphatase gene. Bone 40:1655-1661, 2007
84. Konon I, Cronin ME, Ryan LM: Acute inflammatory syndrome following introduction of mycophenolate mofetil in a patient with systemic lupus erythematosus. Arthritis Care and Research 59:754-756, 2008
85. Rosenthal AK, Fahey M, Gohr C, Burner T, Konon I, Daft L, Mattson E, Hirschmugel C, Ryan LM, Simkin P: Feasibility of a tetracycline-binding method for detecting synovial fluid basic calcium phosphate crystals. Arthritis Rheum 58:3270-3274, 2008
86. Whyte MP, Wenkert D, McAlister WH, Mugahl MZ, Freemont AJ, Whitehouse R, Baildam EM, Coburn SP, Ryan LM, Mumm, S: Chronic recurrent multifocal osteomyelitis mimicked in childhood hypophoshatasia. J Bone Min Res 24:1493-1505, 2009
87. Rosenthal AK, Hempel D, Kurup IV, Masuda I, Ryan LM: Purine receptors modulate chondrocyte extracellular inorganic pyrophosphate production. Osteoarthritis and Cartilage 18:1496-1501, 2010.
88. Costello JC, Rosenthal AK, Kurup IV, Masuda I, Medhora M, Ryan LM: Parallel regulation of extracellular ATP and inorganic pyrophosphate: Roles of growth factors, transduction modulators, and ANK. Conn Tissue Res 52:139-146,2011.
89. Wenkert D, McAlister WH, Coburn SP, Zerega JA, Ryan LM, Ericson KL, Hersh JH, Mumm S, Whyte MP. Hypophosphatasia: nonlethal disease despite skeletal presentation in utero (17 new cases and literature review). J Bone Miner Res. 2011 Oct;26(10):2389-98.
90. Parperis KM, Ryan LM. An unusual cause of destructive monoarthritis. J Clin Rheumatol. 2013 Jun;19(4):225.
91. Parperis K, Carrera G, Baynes K, Mautz A, Dubois M, Cerniglia R, Ryan LM. The prevalence of chondrocalcinosis (CC) of the acromioclavicular (AC) joint on chest radiographs and correlation with calcium pyrophosphate dihydrate (CPPD) crystal deposition disease. Clin Rheumatol. 2013 Sep;32(9):1383-6. PMCID: PMC5025023
92. Rosenthal AK, Gohr CM, Mitton-Fitzgerald E, Lutz MK, Dubyak GR, Ryan LM. The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes. Arthritis Res Ther. 2013 Oct 17;15(5):R154. PMCID: PMC3978574
93. Uzuki M, Sawai T, Ryan LM, Rosenthal AK, Masuda I. Upregulation of ANK protein expression in joint tissue in calcium pyrophosphate dihydrate crystal deposition disease. J Rheumatol. 2014 Jan;41(1):65-74. PMCID: PMC6240442
94. Rosenthal AK, Ryan LM. Nonpharmacologic and pharmacologic management of CPP crystal arthritis and BCP arthropathy and periarticular syndromes. Rheum Dis Clin North Am. 2014 May;40(2):343-56. PMCID: PMC6240445
95. Whyte MP, Coburn SP, Ryan LM, Ericson KL, Zhang F. Hypophosphatasia: Biochemical hallmarks validate the expanded pediatric clinical nosology. Bone. 2018 May;110:96-106.
96. Sabchyshyn V, Konon I, Ryan LM, Rosenthal AK. Concurrence of rheumatoid arthritis and calcium pyrophosphate deposition disease: A case collection and review of the literature. Semin Arthritis Rheum. 2018 Aug;48(1):9-11. PMCID: PMC6240440
97. Rosenthal AK, Ryan LM. Calcium Pyrophosphate Deposition Disease. N Engl J Med. 2016 Jun 30;374(26):2575-84. PMCID: PMC6240444
 
Books, Chapters, and Reviews
1. Ryan LM: Osteoarthritis. In: Current Therapy, H Conn, Ed, WB Saunders Co., Philadelphia, pp 781 783, 1980
2. Ryan LM, McCarty DJ: Articular complications of hemodialysis and uremia. In: Textbook of Nephrology, Chapter 65, pp 7 142/7 146, R Glassock and S. Massry, Eds., 1983
3. Ryan LM: Sacroiliitis: Historic and physical features identify persons at risk. Consultant 21:127 135, 1983
4. Ryan LM, McCarty DJ: Calcium pyrophosphate crystal deposition disease: Pseudogout: Articular chondrocalcinosis. In: Arthritis and Allied Conditions, D.J. McCarty (Ed.), 10th Ed., Lea and Febiger, Philadelphia, PA, pp 1515 1546, 1985
5. Ryan LM: Diagnosis and management of sacroiliitis. Mediguide to Inflammatory Diseases. 4 (6):1 4, 1985
6. Ryan LM: Amyloid arthropathy. In: Amyloidosis, Marrink J, Van Ryswijk M (Eds.), Martinus Nijhoff, Dordrecht Boston Lancaster, pp 267 270, 1986
7. Ryan LM, McCarty DJ: Articular complications in uremia. In: Textbook of Nephrology (2nd Ed.) Glassock R and Massry S (Eds.), Williams and Wilkins Baltimore, MD. 1326 1330, 1989
8. Ryan LM, McCarty DJ: Calcium pyrophosphate crystal deposition disease: Pseudogout: Articular chondrocalcinosis. In: Arthritis and Allied Conditions, D.J. McCarty (Ed.), 11th Ed., Lea and Febiger, Philadelphia, PA. 1711 1736, 1989
9. Rachow JW, Ryan LM: Inorganic pyrophosphate metabolism in arthritis. Rheumatic Disease Clinics of North America 14:289 302, 1989
10. Ryan LM: Joint disorders in renal failure and renal transplant recipients. Mediguide to Inflammatory Diseases, 9:1-5, 1990
11. Ryan LM: Etiopathogenesis of calcium pyrophosphate dihydrate crystal deposition in joints (Chondrocalcinosis). Internal Medicine for the Specialist, 1990
12. Ryan LM, McCarty DJ: Calcium pyrophosphate crystal deposition disease: Pseudogout: Articular chondrocalcinosis. In: Arthritis and Allied Conditions. DJ McCarty (Ed.), 12th Ed., Lea and Febiger, Philadelphia, PA. 1711 1736, 1993
13. Fields T, Ryan L: Crystal induced inflammatory joint disease. Summaries in Clinical Practice: Rheumatic Disorders. SA Paget, T Fields (Eds.), Andover Medical Publishers. Boston. 135-149, 1992
14. Cheung HS, Ryan LM: Role of crystal deposition in matrix degradation. In: Joint Cartilage Degradation: Basic Research and Clinical Implications. F Woessner, DS Howell (Eds.), Marcel Dekker, Inc., New York. 209-223, 1993
15. Ryan LM, Rosenthal AK: Monoarthritis syndromes. In: Current Practice of Medicine, RC Bone (Ed.), Current Medicine. Philadelphia, PA. VI:12.1-VI:12.7, 1995
16. Ryan LM: Calcium pyrophosphate dihydrate deposition disease and other crystal deposition diseases. Current Opinion in Rheumatology 5:517-521, 1993
17. Rosenthal AK, Ryan LM: Treatment of refractory crystal-associated arthritis. Rheumatic Disease Clinics of North America 21:151-161, 1995
18. Ryan LM, McCarty DJ: Calcium pyrophosphate crystal deposition disease; Pseudogout; Articular chondrocalcinosis. In: Arthritis and Allied Conditions, W Koopman (Ed.), 13th Ed., Williams and Wilkins, Baltimore, MD. 2103-2125, 1997
19. Ryan LM, McCarty DJ: Understanding inorganic pyrophosphate metabolism -- toward prevention of calcium pyrophosphate dihydrate crystal deposition. Ann Rheum Dis 54:939-941, 1995
20. Ryan LM: Calcium pyrophosphate dihydrate crystal deposition disease. In: Primer on the Rheumatic Diseases, J Klippel (Ed.), 11th Ed., Arthritis Foundation Press, Atlanta, GA. pp 226-229, 1997
21. Ryan LM, McCarty DJ: Arthritis associated with calcium-containing crystals. In: Internal Medicine, JH Stein (Ed.), 5th Ed., Mosby-Year Book, St. Louis, MO. 1276-1280, 1998
22. Rosenthal AK, Ryan LM: Monoarthritis syndromes. In: Current Practice of Medicine, FT Fitzgerald (Ed.), 2nd Ed., Current Science, Philadelphia, PA. Vol. 2, No. 2, 237-244, 1999
23. Ryan LM, Carrera GF: Diagnostic tests in rheumatic diseases. In: Current Practice of Medicine, FT Fitzgerald (Ed.), 2nd Ed., Current Science, Philadelphia, PA. Vol. 2, No. 2, 131-136, 1999
24. Ryan LM, Cheung HS: The role of crystals in osteoarthritis. Rheumatic Disease Clinics of North America. 25:257-267, 1999
25. Masuda I, Ryan LM, McCarty DJ: Inorganic pyrophosphate metabolism. In: Gout, Hyperuricemia, and Associated Crystal Arthropathies. VM Holers and CJ Smyth (Eds.), Marcel Dekker, New York, NY. 359-367, 1998
26. Halverson PB, Ryan LM: Arthritis associated with calcium-containing crystals. In: Primer on the Rheumatic Diseases, J.Klippel (Ed.), 12th Ed., Arthritis Foundation Press, Atlanta, GA. 299-306, 2001
27. Ryan LM: The ank gene story. Arthritis Res 3:77-79, 2001
28. Rosenthal AK, Ryan LM: Calcium pyrophosphate crystal deposition disease, pseudogout, and articular chondrocalcinosis. In: Arthritis and Allied Conditions, WJ Koopman (Ed.), 14th Ed., Lippincott Williams and Wilkins, Philadelphia, PA, 2348-2371, 2001
29. Ryan LM, Rosenthal AK: Metabolism of extracellular pyrophosphpate. Curr Opin Rheumatol 15:311-314, 2003
30. Rosenthal AK, Ryan LM: Calcium pyrophosphate crystal deposition disease, pseudogout, and articular chondrocalcinosis. In: Arthritis and Allied Conditions, WJ Koopman (Ed.), 15th Ed., Lippincott Williams and Wilkins, Philadelphia, PA, 2373-2396, 2004
31. Rosenthal AK, Ryan LM: Crystals and osteoarthritis. In: Osteoarthritis, K Brandt, M Doherty, LS Lohmander (Eds.), 2nd Ed., Oxford University Press, New York, NY, 120-125, 2003
32. Costello JC, Ryan LM: Modulation of chondrocyte production of extracellular inorganic pyrophosphate. Curr Opin Rheumatol 16:268-272, 2004
33. Jaovisidha J, Ryan LM: Clinical manifestations of basic calcium phosphate (apatite) deposition disease. In: Crystal-Induced Arthropathies: Gout, Pseudogout, and Apatite-Associated Syndromes. Wortmann RL, Schumacher HR, Becker MA, Ryan LM editors. Taylor and Francis Group, New York, NY, 117-134, 2006
34. Ryan LM, Carrera GF: Radiographic changes of crystal-induced arthropathy. In: Crystal-Induced Arthropathies: Gout, Pseudogout, and Apatite-Associated Syndromes. Wortmann RL, Schumacher HR, Becker MA, Ryan LM editors. Taylor and Francis Group, New York, NY, 173-188, 2006
35. Ryan LM, Costello JC: Biochemistry of calcium pyrophosphate dihydrate deposition. In: Crystal-Induced Arthropathies: Gout, Pseudogout, and Apatite-Associated Syndromes. Wortmann RL, Schumacher HR, Becker MA, Ryan LM editors. Taylor and Francis Group, New York, NY, 213-226, 2006
36. Wortmann RL, Ryan LM: Management of crystal-induced arthropathies. In: Crystal-Induced Arthropathies: Gout, Pseudogout, and Apatite-Associated Syndromes. Wortmann RL, Schumacher HR, Becker MA, Ryan LM editors. Taylor and Francis Group, New York, NY, 321-340, 2006
37. Rosenthal AK, Ryan LM: Calcium pyrophosphate deposition-there's nothing "pseudo" about it! Nature Reviews Rheumatology 7:257-258, 2011.
38. Becker MA, Ryan LM: Clinical manifestations and diagnosis of calcium pyrophosphate crystal deposition disease. In: UpToDate. Basow DS editor. UpToDate, Waltham, MA, 2011.
39. Becker MA, Ryan LM: Treatment of calcium pyrophosphate crystal deposition disease. In: UpToDate. Basow DS editor. UpToDate, Waltham, MA, 2011.
40. Becker MA, Ryan LM: Pathogenesis and etiology of calcium pyrophosphate crystal deposition disease. In: UpToDate. Basow DS editor. UpToDate. Waltham, MA, 2011.
 
Editorials, Letters To Editor, Other
1. Ryan LM, Hankwitz P, Banasiak M: Phenformin and pancreatitis. Ann Int Med 88:62 63, 1979
2. Cole DE, Stinson RA, Coburn SP, Ryan LM, Whyte MD: Increased serum pyridoxal 5' phosphate and urinary inorganic pyrophosphate levels in pseudohypophosphatasia. New Eng J Med 314:992 993, 1986
3. Ryan LM: Fact sheet on pseudogout, in Reporter's Guide to Arthritis and Other Diseases of the Joints, Muscles, and Bones, 1994
4. NIH Publication 02-5027, Questions and answers about gout, April 2002
5. Wortmann RL, Schumacher HR, Becker MA, Ryan LM editors. Crystal-Induced Arthropathies: Gout, Pseudogout, and Apatite-Associated Syndromes. Taylor and Francis Group, New York, NY, 2006
6. Halverson PB, Ryan LM: Tidal lavage in Milwaukee Shoulder Syndrome: Do crystals make the difference? J Rheumatol 34:1446-1447, 2007.
 
Abstracts
1. Ryan LM, Bernhard GC, Liang G, Kozin F: Amyloid arthropathy in the absence of dysproteinemia: A possible association with chondrocalcinosis. Presented at the National Scientific Meetings of the American Rheumatism Association, New York, NY, June, 1978 Arthritis Rheum 21:587, 1978
2. Ryan LM, Kozin F, Soin J: Technetium pyrophosphate scanning in the reflex sympathetic dystrophy syndrome. Presented at the Society of Nuclear Medicine, Chicago, IL, February, 1979
3. Ryan LM, Cheung HS, McCarty DJ: Extrusion of inorganic pyrophosphate (PPi) by mature lapine and canine hyaline and fibrocartilage. Presented at the National Meetings of the American Rheumatism Association, Denver, CO, June, 1979. Arthritis Rheum 22:653, 1979
4. Ryan LM, Kozin F, McCarty DJ: Biologic and methodologic variables of plasma inorganic pyrophosphate (PPi) quantification. Presented at the National Meetings of the American Rheumatism Association, Denver, CO, June, 1979. Arthritis Rheum 22:654, 1979
5. Ryan LM, Kozin F, Soin J: Value of technetium pyrophosphate scans in patients with reflex sympathetic dystrophy syndrome. Presented at the Association of University Radiologists, 27th Annual Meeting, Rochester, NY, May, 1979. Investigative Radiology, 1979
6. Foley WD, Carrera GF, Volz DJ, Kozin F, Ryan LM: High resolution CT scanning of sacroiliac arthropathy. Presented at the Association of University Radiologists, 27th Annual Meeting, Rochester, NY, May, 1979. Investigative Radiology, 1979
7. Cheung HS, Ryan LM: Significance of collagen in synovial fluid from arthritis patients. Presented at the Central Rheumatism Society Meeting, St. Louis, MO, December, 1979. Clin Res 28:139A, 1980
8. Carrera GF, Foley WD, Kozin F, Ryan LM, Lawson TL: Computed tomography of the sacroiliac joint in patients with sacroiliitis. Presented at the Central Rheumatism Society meetings, St. Louis, MO, December, 1979. Clin Res 28:139A, 1980
9. Bergeron D, Lawson TL, Carrera GF, Foley WD, Berland LL, Clark K, Kozin F, Ryan LM: Evaluation of the sacroiliac joints by computed tomography: A pathologic radiologic study. Presented at the Canadian Association of Radiologists, Montreal, May, 1980
10. Wortmann RL, Costrini NV, Ryan LM: 5'nucleotidase activity in rabbit chondrocytes. Clin Res 29:490A, 1981
11. Wortmann RL, Costrini NV, Ryan LM: Biological variation of lapine chondrocyte 5'nucleotidase. Presented at the 45th Annual Meeting of the American Rheumatism Association, Boston, MA., June, 1981. Arthritis Rheum 24:S68, 1981
12. Ryan LM, Carrera GF, Kozin F, Lightfoot RW Jr: An approach to the radiographic evaluation of sacroiliitis. Presented at the 8th Annual Meeting of the American Rheumatism Association Regional Meeting, Chicago, IL, November, 1981. Clin Res 29:785A, 1981
13. Whyte MP, Valdez R Jr, Ryan LM, McAlister WH: Infantile hypophosphatasia enzyme replacement therapy by intravenous infusion of alkaline phosphatase rich plasma from patients with Paget's bone disease. Presented at the meetings of the Southern Section, American Federation for Clinical Research, New Orleans, LA, January, 1982. Clin Res 29:841A, 1981. Also presented at the American Society of Human Genetics, October, 1981
14. Ryan LM, Wortmann RL, Karas BJ, McCarty DJ: Nucleoside triphosphate (NTP) pyrophosphohydrolase activity in canine articular cartilage. Presented at the 46th Annual Meeting of the American Rheumatism Association, Washington, D.C., June 1982. Arthritis Rheum 25:S30, 1982
15. Ryan LM, Wortmann RL, Karas BJ, McCarty DJ: Ecto nucleoside triphosphate pyrophosphohydrolase in articular cartilage generates pyrophosphate. Presented at the Ninth Central Regional Meeting, American Rheumatism Association, Chicago, IL., November 1982. Clin Res 30:08A, 1982
16. Halverson PB, McCarty DJ, Cheung HS, Ryan LM: The Milwaukee shoulder syndrome: Report of eight additional cases. Presented at the 47th Annual Meeting, American Rheumatism Association, San Antonio, TX, June 1983. Arthritis Rheum 26:S61, 1983
17. Rachow JW, Ryan LM: Adenosine triphosphate pyrophosphohydrolase and pyrophosphatase activities in human synovial fluid. Presented at the Tenth Central Regional Meeting, American Rheumatism Association, Chicago, IL., November 1983. Clin Res 31:806A, 1983
18. Ryan LM, Wortmann RL, Karas BJ, McCarty DJ: Extracellular inorganic pyrophosphate is generated directly from exogenous ATP by cartilage. Clin Res 31:806A, 1983
19. Rachow JW, Ryan LM: Partial characterization of human synovial fluid ATP pyrophosphohydrolase. Presented at the 48th Annual Meeting of the American Rheumatism Association, Minneapolis, MN., June 1984. Arthritis Rheum 27:S33, 1984
20. Wortmann RL, Veum JA, Ryan LM, Cheung HS: Effects of adenosine deaminase deficiency on rabbit eiphyseal growth plate: Role of purine metabolism in chondro osseous dysplasia. Presented at the 48th Annual Meeting of the American Rheumatism Association, Minneapolis, MN., June 1984. Arthritis Rheum:27:S77, 1984
21. Ryan LM, Wortmann RL, Karas BJ, McCarty DJ: Elevated intracellular pyrophosphate (PPi) and ecto nucleoside pyrophosphohydrolase activity (NTPPPH) in fibroblasts of patients with calcium pyrophosphate dihydrate (CPPD) crystal deposition disease. Presented at the joint meetings of the Central Society for Clinical Research, Chicago, IL., November, 1984. Clin Res 32:792A, 1984
22. Ryan LM, Wortmann RL, Karas BJ, McCarty DJ: Elevated fibroblast inorganic pyrophosphate and ecto nucleoside pyrophosphohydrolase in calcium pyrophosphate dihydrate crystal deposition disease. Presented at the 49th Annual Meeting of the American Rheumatism Association, Anaheim, CA., June 1985. Arthritis Rheum 28:S42, 1985
23. Rachow JW, Ryan LM, Halverson PB: Synovial fluid nucleotide pyrophosphohydrolase levels in basic calcium phosphate deposition arthropathy. Presented at the 49th Annual Meeting of the American Rheumatism Association, Anaheim, CA., June, 1985. Arthritis Rheum 28:S61, 1985
24. Kneeland JB, Carrera GF, Campagna N, Ryan LM, Froncisz W, Jesmanowicz A, Hyde JS: High resolution MRI of rotator cuff tears. Presented at the 4th Annual Meeting, Society of Magnetic Resonance in Medicine, London, U.K., August, 1985 and the Radiological Society of North America, November, 1985
25. Wortmann RL, Ryan LM, Karas BJ, McCarty DJ: Ecto nucleoside triphosphate pyrophosphohydrolase activity and calcium pyrophosphate dihydrate crystal deposition disease. Presented at the 5th International Symposium on Human Purine and Pyrimidine Metabolism, San Diego, CA., July, 1985. Pediatric Research 19:782, 1985
26. Rachow JW, Ryan LM, McCarty DJ: Spontaneous release of extracellular inorganic pyrophosphate and nucleotide pyrophosphohydrolase by porcine articular chondrocytes. Presented at the 12th Central Regional Meeting, American Rheumatism Association, Chicago, IL., November, 1985. Clin Res 33:922A, 1985
27. Bowles C, Harrington T, Zinsmeister A, Ellman M, Reginato A, McCarty DJ, Ryan LM, Espinosa L, Spilberg I, O'Duffy D: Colchicine prevents recurrent pseudogout: Multicenter trial. Presented at the 50th Annual Meeting of the American Rheumatism Association, New Orleans, LA., June, 1986. Arthritis Rheum 29:S36, 1986
28. Rachow JW, Ryan LM, Halverson PB: Synovial fluid pyrophosphate concentration in basic calcium phosphate deposition arthropathy and Milwaukee shoulder syndrome. Presented at the 13th Central Regional Meeting, American Rheumatism Association, Chicago, IL., November, 1986. Arthritis Rheum 30:S17, 1987
29. Ryan LM, Karas B, Kurup I, McCarty DJ: Elaboration of inorganic pyrophosphate by cartilage in organ culture. Presented at the 13th Central Regional Meeting, American Rheumatism Association, Chicago, IL., November, 1986. Arthritis Rheum 30:S19, 1987
30. Ryan LM, Karas B, Kurup I, McCarty DJ: Elaboration of inorganic pyrophosphate (PPi) by cartilage in prolonged organ culture. Presented at the 51st Annual Meeting of the American Rheumatism Association, Washington, D.C., June 1987. Arthritis Rheum 30:S131, 1987
31. Ryan LM, Rachow JW, McCarty DJ: Synovial Fluid ATP: A possible substrate for generation of inorganic pyrophosphate (PPi) in calcium pyrophosphate dihydrate (CPPD) crystal deposition disease. Presented at the 51st Annual Meeting of the American Rheumatism Association, Washington, D.C., June, 1987. Arthritis Rheum 30:S121, 1987
32. Ryan LM, Karas B, Kurup I, McCarty DJ: Cartilage production of inorganic pyrophosphate is independent of proteoglycan production. American Rheumatism Association 52nd Annual Scientific Meeting, May, 1988, Houston, TX. Arthritis Rheum 31:S33, 1988
33. Rosenthal A, Ryan LM: Augmentation of cartilage PPi production by serum factors. American Rheumatism Association 52nd Annual Meeting, Houston, TX., May, 1988. Arthritis Rheum 31:S108, 1988
34. Ryan LM, Rachow JW: Synovial fluid ATP: A potential source of phosphate and pyrophosphate in articular mineralization disorders. Central Society for Clinical Research Meeting, Chicago, IL., November, 1988. Clin Res 36:880A, 1988
35. Rosenthal AK, Cheung HS, Ryan LM: A platelet derived factor(s) stimulates pyrophosphate production by cartilage. Amer College of Rheum, Cincinnati, OH, 1989. Arthritis Rheum 32:S68, 1989
36. Ryan LM, Kurup I: Ascorbate enhances production of inorganic pyrophosphate by cartilage explants. Amer College of Rheum, Cincinnati, OH, 1989. Arthritis Rheum 32:S68, 1989
37. Rosenthal AK, Cheung HS, Ryan LM: A platelet derived factor that stimulates PPi production by articular cartilage is not PDGF. Central Society for Clinical Research, Chicago, IL November, 1989. Clin Res 37:942A, 1989
38. Rosenthal AK, Cheung HS, Ryan LM: TGF and EGF increase pyrophosphate elaboration by articular cartilage. Presented at the American Federation for Clinical Research, November, 1989. Clin Res 38:237A, 1990
39. Rosenthal AK, Cheung HS, Ryan LM: TGF induced PPi stimulation in cartilage is independent of NTPPH activity. Presented at the 54th Scientific Sessions, American College of Rheumatology, Seattle, WA, October, 1990. Arthritis Rheum 33:S38, 1990
40. Rosenthal AK, Cheung HS, Ryan LM: TGF and EGF increase pyrophosphate elaboration by articular cartilage. Central Society for Clinical Research, November, 1990. Clin Research 38:853A, 1990
41. Ryan LM, Cheung HS, Kurup I: Stimulation of cartilage inorganic pyprophosphate production by L ascorbate. Presented at the 54th Scientific Sessions, American College of Rheumatology, Seattle, 1990. Arthritis Rheum 33:S34, 1990
42. Derfus BA, Rachow JW, Mandel N, Buday M, Kushnaryov V, Boskey A, Ryan LM: Articular cartilage vesicles form calcium pyrophosphate dihydrate like crystals. Presented at American Federation for Clinical Research, Seattle, May, 1991. Clin Res 39:249A, 1991
43. Rosenthal AK, McCarty BA, Cheung HS, Ryan LM: TGFß1 stimulates PPi elaboration by articular tissues. Presented at American College of Rheumatology, Boston, 1991. Arthritis Rheum 34:S40, 1991
44. Fife RS, Rachow JW, Ryan LM: Cartilage matrix glycoprotein in plasma (CMGPP) and synovial fluid (CMGPS): Retention in synovial fluids containing basic calcium phosphate (BCP) crystals. American College of Rheumatology, Boston, 1991. Arthritis Rheum 35:S106, 1991
45. Ryan LM, Kurup I: ATP induces cartilage mineralization. Central Society for Clinical Research, Chicago, November, Clin Res 39:702A, 1991
46. Derfus BA, Kushnaryov VM, Kurup I, Ryan LM: ATP dependent articular cartilage crystal generation ultrastructural evidence for vesicle and chondrocyte membrane localization. American College of Rheumatology, Central Regional Meeting, Chicago. Arthritis Rheum 35:S28, 1992
47. Derfus BA, Steinberg M, Kushnaryov VM, Buday M, Ryan LM: Heavy articular cartilage vesicles A new source of calcium pyrophosphate dihydrate (CPPD) crystals. American Federation for Clinical Research, Baltimore, MD. Clin Res 40:142A, 1992
48. Fife RS, Houser D, Proctor C, Kluve Beckerman B, Liepnicks J, Masuda I, McCarty DJ, Ryan LM: Cartilage matrix glycoprotein (CMGP) is a chondrocyte membrane associated protein with sequence homology to ceruloplasmin (CP). American Federation for Clinical Research, Baltimore, MD. Clin Res 40:360A, 1992
49. Masuda I, Haas AL, Ryan LM, McCarty DJ: Purification and characterization of cartilage nucleoside triphosphate pyrophosphohydrolase. American College of Rheumatology, Atlanta, GA. Arthritis Rheum 35:S216, 1992
50. Derfus BA, Kushnaryov V, Boskey A, Mandel N, Kurup I, Ryan LM: Articular cartilage vesicles form calcium pyrophosphate dihydrate crystals in vitro. Presented at the Gordon Conference Calcium Phosphates, Newport, RI, July, 1992
51. Derfus BA, Steinberg M, Kushnaryov VM, Buday M, Ryan LM: Heavy articular cartilage vesicles A new source of calcium pyrophosphate dihydrate (CPPD) crystals. Presented at the 56th meeting American College of Rheumatology, Atlanta, GA, 1992. Arthritis Rheum 35:S119, 1992
52. Rosenthal AK, Rosier TA, Ryan LM: TGFß1 stimulates PPi elaboration from adult human cartilage. American College of Rheumatology, Atlanta, GA, 1992. Arthritis Rheum 35:S75, 1992
53. Rosenthal AK, McCarty BA, Ryan LM: Probenecid blocks TGF stimulated PPi elaboration by cartilage. American College of Rheumaology, Atlanta, GA, 1992. Arthritis Rheum 35:S50, 1992
54. Derfus BA, Kushnaryov VM, Kurup I, Ryan LM: Articular cartilage organ culture generates membrane associated crystals at pathophysiologic ATP concentrations. American College of Rheumatology, Atlanta, GA, 1992. Arthritis Rheum 35:S50, 1992
55. Whyte MP, Habib D, Coburn SP, Tecklenburg F, Ryan L, Fedde KN, Stinson RA: Failure of hyperphosphatasemia by intravenous infusion of placental alkaline phosphatase to correct severe hypophosphatasia. American Society of Bone and Mineral Research, 1992. J Bone and Mineral Res 7:S155, 1992
56. Masuda I, Derfus BA, Ryan LM, McCarty DJ: Genesis of calcium pyrophosphate dihydrate (CPPD) and basic calcium phosphate crystals (BCP). Presented at Osteoarthritis Research Society, Paris, France, 1992. Osteoarthritis and Cartilage 1:16, 1993
57. Rosenthal, AK, Rosier TA, Ryan LM: TGF levels in synovial fluid. Clin Res 41:373A, 1993
58. Derfus BA, Rosenthal AK, Ryan, LM: Transforming growth factor beta and ascorbate each increase mineralizing vesicle elaboration from articular chondrocyte monolayers. Advances in the diagnosis and treatment of osteoarthritis, Boston, MA, 1993
59. Masuda I, Haas AL, Ryan LM, McCarty DJ: Purification and characterization of nucleoside triphosphate pyrophosphhydrolase. ILAR Congress of Rheumatology, Barcelona, Spain. Rev Esp Reumatol 20(S):103, 1993
60. Derfus BA, Kushnaryov V, Daft L, Ryan L: Plasma membranes - A nidus for ATP-dependent articular crystal deposition. Presented at the Biennial Arthritis Foundation Research Conference, June, 1993
61. Olmez U, Kurup IV, Ryan LM: IGF-1 inhibits pyrophosphate elaboration by TGFß stimulated chondrocytes and cartilage. American College of Rheumatology, San Antonio TX, November, 1993. Arthritis Rheum 36:S89, 1993
62. Masuda I, Hamada J, Derfus BA, Haas AL, Ryan LM, McCarty DJ: A unique nucleoside triphosphate pyrophosphohydrolase in chondrocyte vesicles. American College of Rheumatology, San Antonio, TX, November, 1993. Arthritis Rheum 36:S89, 1993
63. Rosenthal AK, Ryan LM: Age influences TGFß1-stimulated cartilage PPi elaboration. American College of Rheumatology, San Antonio, TX, November, 1993. Arthritis Rheum 36:S161, 1993
64. Rosenthal AK, Rosier TA, Ryan LM: TGFß levels in synovial fluid. American College of Rheumatology, San Antonio, TX, November, 1993. Arthritis Rheum 36:S162, 1993
65. Kranendonk S, Ryan L, Buday M, Lynch K, Derfus B: Human osteoarthritic vesicles generate both monoclinic calcium pyrophosphate dihydrate and apatite crystals in vitro. Orthopaedic Research Society, New Orleans, LA, February, 1994. ORS 19:474, 1994
66. McCarthy GM, Ryan LM, Abel SM, Cheung HS: Basic calclium phosphate crystal-induced collagenase production: role of crystal dissolution. American College of Rheumatology, Minneapolis, MN, October, 1994. Arthritis Rheum 37:S412, 1994
67. Derfus BA, Rosenthal AK, Kurup IV, Olmez U, Ryan LM: Transforming growth factor beta and ascorbate each increase mineralizing vesicle elaboration from articular chondrocyte monolayers. American College of Rheumatology, Minneapolis, MN, October, 1994. Arthritis Rheum 37:S413, 1994
68. Derfus BA, Mandel NS, Kranendonk S, Ryan LM: Human osteoarthritic vesicles generate both calcium pyrophosphate dihydrate and apatite crystals in vitro. American College of Rheumatology, Minneapolis, MN, October, 1994. Arthritis Rheum 37:S343, 1994
69. Derfus BA, Honari D, Ryan LM, Kushnaryov VK, Mandel NS: EM diffraction confirms calcium pyrophosphate dihydrate deposition by articular cartilage vesicles. American College of Rheumatology, Minneapolis, MN, October, 1994. Arthritis Rheum 37:S412, 1994
70. Chines A, Coburn S, Mahuren D, Landt M, Ryan L, Whyte M: Hypophosphatasia: diagnostic sensitivity of assay for alkaline phosphatase, phosphoethanolamine, inorganic pyrophosphate, and pyridoxal 5'-phosphate. J Bone Mineral Res 9:S425, 1994
71. Long C, Kurup I, Ryan L, Toth J, Kushnaryov V, Derfus B: Articular cartilage vesicles are heterogeneous in enzyme content and biomineralization capacity. American College of Rheumatology, San Francisco, CA, October, 1995. Arthritis Rheum 38:S162, 1995
72. Masuda I, Halligan BD, Barbieri JT, Haas AL, Ryan LM, McCarty DJ: Molecular cloning of a unique ecto-nucleoside triphosphate pyrophosphohydrolase from porcine articular chondrocytes. American College of Rheumatology, Orlando, FL, October, 1996. Arthritis Rheum 39:S83, 1996
73. Cardenal A, Masuda I, Ono W, Haas AL, Ryan LM, Csuka ME, Trotter D, McCarty DJ: Serum nucleoside triphosphate pyrophosphohydrolase activity: elevated levels in osteoarthritis, calcium pyrophosphate crystal deposition disease and fibromyalgia. American College of Rheumatology, Orlando, FL, October, 1996. Arthritis Rheum 39:S83, 1996
74. Westfall PR, Cheung H, Ryan L, Derfus B: Phosphocitrate inhibits mineralization of matrix vesicles derived from human osteoarthritic cartilage. American College of Rheumatology, Orlando, FL, October, 1996. Arthritis Rheum 39:S226, 1996
75. Masuda I, Ken-ichi I, Haas AL, Ryan LM, McCarty DJ: Immunolocalization of 61-kD nucleotide pyrophosphohydrolase (NTPPPHase) in adult and neonatal porcine articular cartilage. American College of Rheumatology, Washington, D.C., 1997. Arthritis Rheum 40:S185, 1997
76. Westfall P, Cheung H, Sauberan D, Ryan L, Derfus B: Phosphocitrate inhibits mineralization of matrix vesicles derived from human osteoarthritic meniscus. American College of Rheumatology, Washington, D.C., 1997. Arthritis Rheum 40:S187, 1997
77. Masuda I, Iyama K, Halligan BD, Barbieri JT, Haas AL, Ryan LM, McCarty DJ: Localized expression of chondrocyte nucleotide pyrophosphohydrolase in adult and juvenile porcine articular cartilages. Orthopaedic Research Society, Hamamatsu, Shizuoka, Japan, 1998. Transactions of the Third Combined Meeting of the Ortopaedic Research Societies of the U.S.A., Canada, Europe and Japan, p.320, 1998
78. Mc Carthy GM, Cheung HS, LeGeros RZ, Kurup IV, Toth J, Westfall PR, Ryan LM: Whitlockite crystals induce mitogenesis and matrix metalloprotease (MMP) induction in human fibroblasts. American College of Rheumatology, Boston, MA, 1999. Arthritis Rheum 42:S158, 1999
79. Masuda I, Dahly AJ, Zhou X, Halligan BD, Barbieri JT, Ryan LM: IGF-1 down-regulates nucleotide pyrophosphohydrolase (NTPPHASE) expression in adult porcine chondrocytes. American College of Rheumatology, Boston, MA, 1999. Arthritis Rheum 42:S256, 1999
80. Hirose J, Masuda I, Zhou X, Kurup I, Ryan L: Difference of CILP/NTPPH response to growth factors during age. Orthopaedic Research Society, Orlando, FL, 2000. Trans ORS 25:0920, 2000
81. Hirose J, Masuda I, Ryan LM: Difference of expression between cartilage intermediate layer protein/nucleotide pyrophosphohydrolase (CILP/NTPPH) and plasma cell membrane glycoprotein-1 (PC-1)?NTPPH in response to growth factors and with aging. American College of Rheumatology, Philadelphia, PA, 2000. Arthritis Rheum 43:S121, 2000
82. Ryan LM, Barbieri J, Halligan B, Kurup I, Masuda I: Adenylyl cyclase activation reduces chondrocyte pyrophosphate elaboration. American College of Rheumatology, Philadelphia, PA, 2000. Arthritis Rheum 43:S402, 2000
83. Jaovisidha K, Hung J, Ning G, Ryan LM, Derfus BA: Comparative biomineralization of native articular cartilage matrix vesicles and nitroprusside-generated apoptotic bodies. American College of Rheumatology, Philadelphia, PA, 2000. Arthritis Rheum 43:S402, 2000
84. Hirose J, Masuda I, Ryan LM: Expression of cartilage intermediate layer protein/nucleotide pyrophosphohydrolase (CILP/NTPPH) parallels the production of extracellular inorganic pyrophosphate from normal human articular chondrocytes in response to growth factors and with aging. American College of Rheumatology, San Francicsco, CA, 2001. Arthritis Rheum 44:S44, 2001
85. Hirose J, Masuda I, Ryan LM: Up-regulated expression of cartilage intermediate layer protein (CILP) in articular chondrocytes from calcium pyrophosphate dihydrate crystal deposition disease. American College of Rheumatology, San Francisco, CA, 2001. Arthritis Rheum 44:S44, 2001
86. Hirose J, Masuda I, Ryan LM: Up-regulated expression of cartilage intermediate layer protein (CILP) in articular chondrocytes from calcium pyrophosphate dihydrate crystal deposition disease. American College of Rheumatology, San Francisco, CA, 2001. Arthritis Rheum 44:S451, 2001
87. Masuda I, Ikegawa S, Hirose J, Ryan L: ATP-dependent mineralization of osteoblastic cells from "tiptoe walking" (ttw) mice is impaired in vitro. Orthopaedic Research Society, San Francisco, CA, 2001. Trans ORS 26:0041, 2001
88. Masuda I, Barbieri JT, Hewlett EL, Kurup I, Ryan LM: Inhibition of chondrocyte pyrophosphate elaboration by bacterial toxin. American College of Rheumatology, New Orleans, LA, 2002. Arthritis Rheum 46:S81, 2002
89. Wenkert D, Podgornik MN, Coburn SP, Ryan LM, Mumm S, Whyte MP: Dietary phosphate restriction therapy for hypophosphatasia: Preliminary observations. J Bone Miner Res 17:S384, 2002
90. Costello JC, Kurup IV, Masuda I, Ryan LM: Growth factor regulation of extracellular adenosine triphosphate elaboration by articular chondrocytes. Central Society for Clinical Research/ Midwest American Federation for Medical Research, Chicago, IL, 2004. J Invest Med 52(2), S347, 2004
91. Uzuki M, Ryan LM, Sawai T, Kingsley DM, Masuda I: Up-regulated expression of ANK in joint tissue from patients with calcium pyrophosphate dihydrate crystal deposition disease. American College of Rheumatology, San Antonio, TX, 2004. Arthritis Rheum 50:S247, 2004
92. Costello JC, Ryan LM, Kurup IV, Masuda I: ANK increases extracellular ATP in chondrocyte cultures. American College of Rheumatology, San Antonio, TX, 2004.