Medical College of Wisconsin
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CURRICULUM VITAE

Lu Han PhD
Assistant Professor
Department of Pediatrics
Division of Cardiology

OFFICE ADDRESS:
Children's Hospital
9000 W Wisconsin Ave
Milwaukee, WI 53226

EDUCATION:
09/1999 - 07/2003 BS, Jilin University, Changchun, China
09/2003 - 08/2010 PhD, Institute of Biophysics-Chinese Academy of Sciences, Beijing, China

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
03/07/2011 - 08/31/2016 Postdoctoral Fellow, Department of Developmental Biology
09/01/2016 - 08/31/2020 Research Associate, Department of Pediatrics, Division; University of Pittsburgh, Cardiology, PA

FACULTY APPOINTMENTS:
09/01/2020 - 08/31/2021 Research Assistant Professor, Department of Pediatrics, Cardiology Division; University of Pittsburgh, PA
09/01/2021 - Present Assistant Professor, Department of Pediatrics, Herma Heart Institute, Medical College of Wisconsin

AWARDS AND HONORS:
2002 - Present Cum Laude Honors & Scholarship, Jilin University, Changchun China
2007 - Present Outstanding Student Award (corresponding to Cum Laude Honor)
2013 - Present Best Poster Presentation Award, 1st xCELLigence Cardio Symposium, Washington DC
2013 - Present Travel Award for 1st xCELLigence Cardio Symposium, Washington DC
2014 - Present Best Poster Presentation Award, Rangos Research Symposium, Pittsburgh, PA
2015 - Present Award for Randall Big Idea Competition, Pittsburgh, PA
2015 - Present Travel Award for Weinstein Conference, Boston, MA
2018 - Present American Heart Associate, Career Development Award, National
Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
2016 - Present Member of American Heart Association

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Journal Review
10/2020 - Present Member, NIH Study Section, Integrative Myocardial
Journal of Molecular and Cellular Cardiology (JMCC)
Elife
Science Translational Medicine
Marrow
Frontiers in Cardiovascular Medicine
Physiology/Pathophysiology B
Grant Review
Biotechnology and Biological Sciences Research Council (BBSRC), UK
National Heart, Lung, and Blood Institute (NHLBI)
NATIONAL/INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
Journal of Visualized Experiments (JoVE)
Frontiers in Cell and Developmental Biology

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Collaborative Research into the Etiology and Treatment of
Source:
AHW-Research and Education Program
Role:
Principal Investigator, Start-up Funding
Dates:
07/01/2021 - 06/30/2023
 
Prior
Peer Review
Title:
LMNB2 determines heart muscle cell regeneration and
Source:
AHA (American Heart Association)
Role:
Principal Investigator
Dates:
07/01/18 - 06/30/21
Direct Funds:
$210,000 (total for all years)
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
Lu Han, Herma Heart Institute, Department of Pediatrics, Medical College of Wisconsin
 

PEER REVIEWED WORKSHOPS/PRESENTATIONS:
Local
Pittsburgh, PA (Jan 17, 2020)
from McGowan Seminar Series, Pittsburgh (Feb 25, 2020)
Lu Han, Terminal differentiation of heart muscle cells. Invited as a mentor-trainee pair
from Prochownik Seminar Series, Pittsburgh (Feb 24, 2020)
Lu Han, Decreased nuclear import in cardiomyocyte terminal differentiation. Abstract
selected for platform presentation at American Heart Association Fellow Research Day.
Lu Han, Terminal differentiation of heart muscle cells. Invited as a mentor-trainee pair
 
National
Lu Han, Lamin B2 controls M-phase progression and cardiomyocyte regeneration.
Leducq Foundation Meeting. Chicago, IL (Nov. 8, 2018)
Lu Han, Lamin B2 Regulates Proliferation and Survival of Human iPS Cell-Derived
Cardiomyocytes. Leducq Foundation Meeting. San Francisco, CA (Nov 17, 2017)
 
International
Lu Han, Decreased Expression of Lamin B2 Induces Polyploidization of Cardiomyocyte Nuclei and Induces Cell Cycle Withdrawal. Abstract selected for platform presentation at American Heart Association Scientifi, PA (Nov 17, 2019)
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
Undergraduate Students
Jocelyn D. Mich-Basso, University of Pittsburgh, 09/2016 - 08/2020 09/2016-08/2020
Kyla S. Holbrook, Columbia University, 06/2018 - 09/2018 06/2018-09/2018
06/2019 - 09/2019 Summer Program mentor
Dilara Ozdoganlar, Carnegie Mellon University, 06/2019 - 09/2019 Summer Program
Katelyn Parsons, Carnegie Mellon University, 09/2019 - 03/2020 Research mentor
Anita Bargaje, University of Pittsburgh, 09/2020 - 08/2021 Research mentor
Senior Research Assistant
mentor
 
Graduate Students
PhD Students Advised
Jennifer Spengler, University of Pittsburgh, 06/2018 - 09/2018 Rotation student
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Han L, Choudhury S, Mich-Basso JD, Ammanamanchi N, Ganapathy B, Suresh S, Khaladkar M, Singh J, Maehr R, Zuppo DA, Kim J, Eberwine JH, Wyman SK, Wu YL, Kuhn B. Lamin B2 Levels Regulate Polyploidization of Cardiomyocyte Nuclei and Myocardial Regeneration. Dev Cell. 2020. Epub 2020/02/29. doi: 10.1016/j.devcel.2020.01.030. PubMed PMID: 32109383.
2. Liu H, Zhang CH, Ammanamanchi N, Suresh S, Lewarchik C, Rao K, Uys GM, Han L, Abrial M, Yimlamai D, Ganapathy B, Guillermier C, Chen N, Khaladkar M, Spaethling J, Eberwine JH, Kim J, Walsh S, Choudhury S, Little K, Francis K, Sharma M, Viegas M, Bais A, Kostka D, Ding J, Bar-Joseph Z, Wu Y, Yechoor V, Moulik M, Johnson J, Weinberg J, Reyes-Mugica M, Steinhauser ML, Kuhn B. Control of cytokinesis by beta-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment. Sci Transl Med. 2019;11(513). Epub 2019/10/11. doi: 10.1126/scitranslmed.aaw6419. PubMed PMID: 31597755.
3. Lin B, Li Y, Han L, Kaplan AD, Ao Y, Kalra S, Bett GC, Rasmusson RL, Denning C, Yang L. Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy. Dis Model Mech. 2015;8(5):457-66. Epub 2015/03/21. doi: 10.1242/dmm.019505. PubMed PMID: 25791035; PMCID: PMC4415895.
4. Han L, Li Y, Tchao J, Kaplan AD, Lin B, Li Y, Mich-Basso J, Lis A, Hassan N, London B, Bett GC, Tobita K, Rasmusson RL, Yang L. Reconciling computer models and stem cell models of human cardiac repolarization: reply. Cardiovasc Res. 2015;106(1):6-7. Epub 2015/02/19. doi:10.1093/cvr/cvv039. PubMed PMID: 25691542.
5. Tchao J, Han L, Lin B, Yang L, Tobita K. Combined biophysical and soluble factor modulation induces cardiomyocyte differentiation from human muscle derived stem cells. Sci Rep. 2014;4:6614. Epub 2014/10/15. doi: 10.1038/srep06614. PubMed PMID: 25310989; PMCID: PMC4196107.
6. Han L, Li Y, Tchao J, Kaplan AD, Lin B, Li Y, Mich-Basso J, Lis A, Hassan N, London B, Bett GC, Tobita K, Rasmusson RL, Yang L. Study familial hypertrophic cardiomyopathy using patientspecific induced pluripotent stem cells. Cardiovasc Res. 2014;104(2):258-69. Epub 2014/09/12. doi: 10.1093/cvr/cvu205. PubMed PMID: 25209314; PMCID: PMC4217687.
7. Lu TY, Lin B, Li Y, Arora A, Han L, Cui C, Coronnello C, Sheng Y, Benos PV, Yang L.Overexpression of microRNA-1 promotes cardiomyocyte commitment from human cardiovascular progenitors via suppressing WNT and FGF signaling pathways. J Mol Cell Cardiol. 2013;63:146-54. Epub 2013/08/14. doi: 10.1016/j.yjmcc.2013.07.019. PubMed PMID: 23939491; PMCID: PMC4268488.
8. Han L, Hu Z, Liu Y, Wang X, Hopkins KM, Lieberman HB, Hang H. Mouse Rad1 deletion enhances susceptibility for skin tumor development. Mol Cancer. 2010;9:67. Epub 2010/03/26. doi: 10.1186/1476-4598-9-67. PubMed PMID: 20334655; PMCID: PMC2864214.
9. Cui P, Lin Q, Xin C, Han L, An L, Wang Y, Hu Z, Ding F, Zhang L, Hu S, Hang H, Yu J. Hydroxyurea-induced global transcriptional suppression in mouse ES cells. Carcinogenesis. 2010;31(9):1661-8. Epub 2010/06/02. doi: 10.1093/carcin/bgq106. PubMed PMID: 20513671.
10. He W, Zhao Y, Zhang C, An L, Hu Z, Liu Y, Han L, Bi L, Xie Z, Xue P, Yang F, Hang H. Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1. Nucleic Acids Res. 2008;36(20):6406-17. Epub 2008/10/10. doi: 10.1093/nar/gkn686. PubMed PMID: 18842633; PMCID: PMC2582629.
11. Hu Z, Liu Y, Zhang C, Zhao Y, He W, Han L, Yang L, Hopkins KM, Yang X, Lieberman HB, Hang H. Targeted deletion of Rad9 in mouse skin keratinocytes enhances genotoxin-induced tumor development. Cancer Res. 2008;68(14):5552-61. Epub 2008/07/18. doi: 10.1158/0008-5472.CAN-07-5670. PubMed PMID: 18632607; PMCID: PMC4331354.
 
Books, Chapters, and Reviews
1. Han L, Mich-Basso JD, Kühn B. Generation of human-induced pluripotent stem cells and differentiation into cardiomyocytes. Method in Molecular Biology. Springer Nature 2020.
2. Kirillova A, Han L, Liu H, and Kuhn B. Karyokinesis and cytokinesis failure generate polyploid cardiomyocytes and establish barriers for heart regeneration. Development, 2021; 148 (14): dev199401