CURRICULUM VITAE
Melanie Gartz PhD
Melanie Gartz PhD
Assistant Professor
Department of Cell Biology, Neurobiology and Anatomy
Department of Cell Biology, Neurobiology and Anatomy
OFFICE ADDRESS: |
Basic Science Building |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
EDUCATION: |
08/2005 - 05/2009 BS, Clinical Laboratory Science, University of Wisconsin-Milwaukee, Milwaukee |
08/2010 - 05/2011 MHS, Molecular Microbiology and Immunology Johns Hopkins University, Baltimore, MD |
08/2012 - 05/2014 MS, Cell Biology, Medical College of Wisconsin, Milwaukee |
08/2017 - 06/2020 PhD, Cell Biology, Medical College of Wisconsin, Milwaukee |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
07/01/2020 - 06/30/2022 Postdoctoral Fellow, Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI |
07/01/2020 - 06/30/2022 Anatomy Education Trainee, Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI |
07/2021 - 06/2022 KINETIC3 Scholar, Medical Educator Track, Kern Institute, Medical College of Wisconsin, Milwaukee, WI |
AWARDS AND HONORS: |
09/2005 - 05/2009 Dean's List, University of Wisconsin Milwaukee, College of Health Sciences |
09/2008 - Present Honors Science Scholar, University of Wisconsin Milwaukee, College of Health Sciences |
03/2016 - Present Best Poster, Department of Medicine Research Retreat |
09/2017 - Present Best Poster, Graduate Student Poster Session |
11/2017 - Present Outstanding Medical Student Teacher |
03/2018 - Present Best Poster, Graduate Student Research Symposium |
09/2018 - Present Graduate Student Award, Women in Science Committee |
09/2018 - Present Best Poster, Graduate Student Poster Session |
11/2018 - Present Outstanding Medical Student Teacher |
03/2019 - Present Best Presentation, Graduate Student Research Symposium |
09/2019 - Present Best Poster, Graduate Student Poster Session |
11/2019 - Present Outstanding Medical Student Teacher |
11/2019 - Present Outstanding Medical Student Teacher |
11/2021 - Present Outstanding Medical Student Teacher |
06/2022 - Present Karen Marcdante Bravery in Teaching Award |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
09/2017 - 07/2020 American Heart Association |
09/2018 - 07/2020 International Society for Extracellular Vesicles |
01/2020 - Present present (American Association of Clinical Anatomists) |
01/2020 - Present present (American Association for Anatomy) |
INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
Local |
Myocyte-derived exosomes acutely protect DMD-human cardiomyocytes against stress-induced injury through a surface protein and ERK1/2-p38/MAPK signaling. Froedtert Hospital, Department of Cardiology Grand Rounds, Milwaukee, - 08/2017 |
Long-term DMD cardiac exosome exposure fails to protect DMD cardiomyocytes against the effects of oxidative stress. Medical College of Wisconsin Department of Medicine Conference, Milwaukee, - 03/2019 |
Long-term DMD cardiac exosome exposure fails to protect DMD cardiomyocytes against the effects of oxidative stress. Graduate Student Research Symposium, Medical College of Wisconsin, Milwaukee, - 03/2019 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
International |
Dystrophic iPSC-derived Cardiomyocytes have Mislocalization of eNOS and Increased Susceptibility to Cell Death which is reversed by the Nitrate-like Properties of Nicorandil. American Heart Association Basic Cardiovascular Sciences Scientific Sessions, Las Vegas, - 07/2014 |
Myocyte-derived exosomes acutely protect DMD-human cardiomyocytes against stress-induced injury through a surface protein and ERK1/2-p38/MAPK signaling. American Heart Association Scientific Sessions, Anaheim, - 11/2017 |
Duchenne Muscular Dystrophy Cardiac Exosomes Contribute to the Pathogenesis of Dystrophin-deficient Cardiomyopathy. American Heart Association Basic Cardiovascular Sciences Scientific Sessions, Boston, - 07/2019 |
National |
Exosome treatment shows protection against stress in dystrophin-deficient human-iPSC-derived cardiomyocytes." New Directions in Biology and Disease of Skeletal Muscle Conference, Orlando, - 06/2016 |
Nicorandil protects against oxidative stress in dystrophic iPSC-derived cardiomyocytes. New Directions in Biology and Disease of Skeletal Muscle Conference, Chicago, - 06/2014 |
Regional |
Divergent Paracrine Effects of Acute vs. Chronic Cardiac Exosome Exposure in DMD iPSC-derived cardiomyocytes. Harmony 4 Hope Rare Storytellers Series, Milwaukee, - 09/2018 |
Local |
Duchenne Muscular Dystrophy Cardiac Exosomes Contribute to the Pathogenesis of Dystrophin-deficient Cardiomyopathy. Medical College of Wisconsin Cardiovascular Center Research Retreat, 10/2019; Medical College of Wisconsin Graduate Student Poster Day, Milwaukee, - 11/2019 |
cardiomyocytes. Medical College of Wisconsin Graduate Student Poster Day, Milwaukee, - 10/2013 |
Long-term DMD cardiac exosome exposure fails to protect DMD cardiomyocytes against the effects of oxidative stress. March 2019 - Medical College of Wisconsin Department of Medicine Conference, Milwaukee, - 03/2019 |
Nicorandil protects against oxidative stress in dystrophic iPSC-derived |
Myocyte-derived exosomes acutely protect DMD-human cardiomyocytes against stress-induced injury through a surface protein and ERK1/2-p38/MAPK signaling. Medical College of Wisconsin Graduate Student Poster Day, Milwaukee, WI. 11/2017; Medical College of Wisconsin Graduate Student Research Symposium, Milwaukee, WI. 03/2018; Medical College of Wisconsin Cardiovascular Center Research Retreat, Milwaukee, - 10/2018 |
Divergent Paracrine Effects of Acute vs. Chronic Cardiac Exosome Exposure in DMD iPSC-derived cardiomyocytes. November 2018 - Medical College of Wisconsin Graduate Student Poster Day, Milwaukee, - 11/2018 |
Dystrophic iPSC-derived Cardiomyocytes have Mislocalization of eNOS and Increased Susceptibility to Cell Death which is reversed by the Nitrate-like Properties of Nicorandil. Medical College of Wisconsin Redox Biology Symposium, Milwaukee, - 03/2015 |
Exosome treatment shows protection against stress in dystrophin-deficient human-iPSC-derived cardiomyocytes. Medical College of Wisconsin Department of Medicine Research Retreat, Milwaukee, WI. 03/2016; Medical College of Wisconsin Research Day, Milwaukee, - 09/2016 |
Exosome treatment confers protection against stress in dystrophin-deficient human-iPSC-derived cardiomyocytes through ERK1/2-p38/MAPK signaling. Medical College of Wisconsin Dept of Medicine Research Retreat, Milwaukee, WI. 03/2017; Medical College of Wisconsin Cardiovascular Center Research Retreat, Milwaukee, - 04/2017 |
MCW TEACHING ACTIVITIES: |
Medical Student Education |
02/2017 - Present present, Lecturer and Small Group Facilitator, Molecular and Cellular |
08/2020 - Present present, Lecturer in Foundations of Pathological Processes - |
08/2020 - Present present, Lecturer in Clinical Human Anatomy I & II |
07/2021 - Present present, Lecturer for 500 Stars summer program, Cadavers as |
09/2021 - Present present, Small Group Facilitator for Interprofessional Education |
07/2022 - Present present, Director of Musculoskeletal Skin block (new curriculum) |
Educators sessions |
Sessions and Professionalism in Clerkships |
Research Pathway |
Musculoskeletal Skin |
Community/Lay Public |
02/2020 - Present Anatomy Nights: Educating the public on heart structure, function and |
02/2020 - Present Anatomy Nights: Educating the public on heart structure, function and |
04/2022 - Present Life in Medical School: A Discussion on How to Plan and What to |
07/2022 - Present Career Chats: My Journey into Science and Medical Education. Medical |
07/2022 - Present Anatomy Lab Tour and Sheep Heart Dissection, Medical College of |
Expect in the Early Years and Beyond. University of Wisconsin Milwaukee, |
College of Wisconsin SPUR Program. |
disease. Milwaukee, WI. |
AMSA Student Group, Milwaukee, WI. |
Wisconsin Latino Medical Student Association, AIM Program. |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
High School Students |
500 - Present Daeleon Brown-Williams, Stars Summer Program, 06/2017-08/2017 |
Aashay Mardikar, High School Intern, 06/2021-08/2021 |
Elizabeth Cinquegrani, High School Intern, 06/2018-08/2018 |
Undergraduate Students |
500 - Present Claire Piehowski, Stars Summer Program, 06/2018-08/2018 |
Ceshae Harding, DSHREP Summer Program, 06/2014-08/2014 |
Medical Students |
Pathways Program |
Ashley Darlington, MCW, MD, 06/2015-05/2016. Physician Scientist Research |
COMMUNITY SERVICE ACTIVITIES: |
01/2017 - 12/2019 Assisted with journal reviews (Dr. Jennifer Strande, Main |
05/2018 - 05/2019 Cardiovascular Center Research Retreat Abstract Review |
04/2019 - Present STEaM Girls Summit - Engaging girls to pursue jobs in the STEM fields. |
07/2020 - 07/2021 Spotlight on Science preparation committee - Inviting and |
planning for seminar speakers to engage with graduate students and postdoctoral fellows contemplating their careers. Milwaukee, WI. |
Committee Medical College of Wisconsin, Cardiovascular Research Center |
invite school-aged kids and community members to learn about the human brain. Milwaukee, WI. |
DNA Breakout session facilitator, Milwaukee, WI. |
invite school-aged kids and community members to learn about the human brain. Milwaukee, WI. |
- 04/2020 |
Reviewer), various journals. |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. (Maiden name: Reiter) |
2. Melanie Gartz; Margaret Haberman; Mariah J. Prom; Margaret J. Beatka; Jennifer L. Strande; Michael W. Lawlor. A long-term study evaluating the effects of nicorandil treatment on Duchenne muscular dystrophy-associated cardiomyopathy in mdx mice. J Cardiovasc Pharmacol Ther. 2022 Jan-Dec;27: 10742484221088655.. |
3. Melanie Gartz and Jennifer L. Strande. Optimizing the Differentiation of Cardiomyocytes from Human Induced Pluripotent-Derived Stem Cells. Methods Mol Biol. 2021;2319:51-60. |
4. Melanie Gartz; Margaret Beatka; Mariah J. Prom; Jennifer L. Strande; Michael W. Lawlor. Cardiomyocyte-produced miR-339-5p mediates pathology in Duchenne muscular dystrophy cardiomyopathy. Hum Mol Genet. 2021 Nov 16;30(23):2347-2361. |
5. Melanie Gartz; Chien-Wei Lin; Mark Sussman; Michael Lawlor and Jennifer L. Strande. Duchenne muscular dystrophy cardiomyocyte-secreted exosomes promote the pathogenesis of DMD-associated cardiomyopathy. Disease Models and Mechanisms, 2020 Nov 13;13(11):dmm045559. |
6. Melanie Gartz; Ashley Darlington; Zeeshan Afzal and Jennifer L. Strande. Exosomes exert cardioprotection in dystrophin-deficient cardiomyocytes via ERK1/2-p38/MAPK signaling. Scientific Reports, 2018 Jun 5; 7(11): e007954. |
7. Zeeshan Afzal; Melanie Gartz; Ekaterina A Klyachko; Sadiya S Khan; Sanjiv J Shah; Sweta Gupta; Amy D Shapiro; Douglas E Vaughan Jennifer L Strande. Generation of Human iPSCs from Urine Derived Cells of Patient with a Novel Heterozygous PAI-1 Mutation. Stem Cell Research, 2017 Jan;18:41-44. |
8. Zeeshan Afzal; Melanie Gartz; Ekaterina A Klyachko; Sadiya S Khan; Sanjiv J Shah; Sweta Gupta; Amy D Shapiro; Douglas E Vaughan Jennifer L Strande. Generation of Human iPSCs from Urine Derived Cells of Patient from a non-affected control subject. Stem Cell Research, 2017 Jan;18:33-36. |
9. Alison J. Kriegel; Melanie Gartz; Zeeshan Afzal; Willem J. De Lange; J. Carter Ralphe and Jennifer L. Strande. Molecular approaches to precision medicine in HFpEF: MicroRNAs and iPSC-derived cardiomyocytes. Journal of Cardiovasc Translational Research, 2016 Dec 28, 10:295-304. |
10. Zeeshan Afzal; Melanie Gartz; Ekaterina A Klyachko; Sadiya S Khan; Sanjiv J Shah; Sweta Gupta; Amy D Shapiro; Douglas E Vaughan and Jennifer L Strande. Generation of Human iPSCs from Urine Derived Cells of Patient with a Novel Homozygous PAI-1 Mutation. Stem Cell Research, 2016 Nov;17(3):657-660. |
11. Zeeshan Afzal*; Melanie Reiter*; Courtney Gastonguay,; Jered V. McGivern; Xuan Guan; Zhi-Dong Ge; David L. Mack; Martin K. Childers; Allison D. Ebert and Jennifer L. Strande. Nicorandil, a Nitric Oxide Donor and ATP-Sensitive Potassium Channel Opener, Protects Against Dystrophin-Deficient Cardiomyopathy. J Cardiovasc Pharmacol Ther. 2016 Nov;21(6):549-562. |
12. *Denotes co-first authorship |
13. (Maiden name: Reiter) |
14. Melanie Gartz; Margaret Haberman; Mariah J. Prom; Margaret J. Beatka; Jennifer L. Strande; Michael W. Lawlor. A long-term study evaluating the effects of nicorandil treatment on Duchenne muscular dystrophy-associated cardiomyopathy in mdx mice. J Cardiovasc Pharmacol Ther. 2022 Jan-Dec;27: 10742484221088655.. |
15. Melanie Gartz and Jennifer L. Strande. Optimizing the Differentiation of Cardiomyocytes from Human Induced Pluripotent-Derived Stem Cells. Methods Mol Biol. 2021;2319:51-60. |
16. Melanie Gartz; Margaret Beatka; Mariah J. Prom; Jennifer L. Strande; Michael W. Lawlor. Cardiomyocyte-produced miR-339-5p mediates pathology in Duchenne muscular dystrophy cardiomyopathy. Hum Mol Genet. 2021 Nov 16;30(23):2347-2361. |
17. Melanie Gartz; Chien-Wei Lin; Mark Sussman; Michael Lawlor and Jennifer L. Strande. Duchenne muscular dystrophy cardiomyocyte-secreted exosomes promote the pathogenesis of DMD-associated cardiomyopathy. Disease Models and Mechanisms, 2020 Nov 13;13(11):dmm045559. |
18. Melanie Gartz; Ashley Darlington; Zeeshan Afzal and Jennifer L. Strande. Exosomes exert cardioprotection in dystrophin-deficient cardiomyocytes via ERK1/2-p38/MAPK signaling. Scientific Reports, 2018 Jun 5; 7(11): e007954. |
19. Zeeshan Afzal; Melanie Gartz; Ekaterina A Klyachko; Sadiya S Khan; Sanjiv J Shah; Sweta Gupta; Amy D Shapiro; Douglas E Vaughan Jennifer L Strande. Generation of Human iPSCs from Urine Derived Cells of Patient with a Novel Heterozygous PAI-1 Mutation. Stem Cell Research, 2017 Jan;18:41-44. |
20. Zeeshan Afzal; Melanie Gartz; Ekaterina A Klyachko; Sadiya S Khan; Sanjiv J Shah; Sweta Gupta; Amy D Shapiro; Douglas E Vaughan Jennifer L Strande. Generation of Human iPSCs from Urine Derived Cells of Patient from a non-affected control subject. Stem Cell Research, 2017 Jan;18:33-36. |
21. Alison J. Kriegel; Melanie Gartz; Zeeshan Afzal; Willem J. De Lange; J. Carter Ralphe and Jennifer L. Strande. Molecular approaches to precision medicine in HFpEF: MicroRNAs and iPSC-derived cardiomyocytes. Journal of Cardiovasc Translational Research, 2016 Dec 28, 10:295-304. |
22. Zeeshan Afzal; Melanie Gartz; Ekaterina A Klyachko; Sadiya S Khan; Sanjiv J Shah; Sweta Gupta; Amy D Shapiro; Douglas E Vaughan and Jennifer L Strande. Generation of Human iPSCs from Urine Derived Cells of Patient with a Novel Homozygous PAI-1 Mutation. Stem Cell Research, 2016 Nov;17(3):657-660. |
23. Zeeshan Afzal*; Melanie Reiter*; Courtney Gastonguay,; Jered V. McGivern; Xuan Guan; Zhi-Dong Ge; David L. Mack; Martin K. Childers; Allison D. Ebert and Jennifer L. Strande. Nicorandil, a Nitric Oxide Donor and ATP-Sensitive Potassium Channel Opener, Protects Against Dystrophin-Deficient Cardiomyopathy. J Cardiovasc Pharmacol Ther. 2016 Nov;21(6):549-562. |
24. *Denotes co-first authorship |
25. (Maiden name: Reiter) |
26. Melanie Gartz; Margaret Haberman; Mariah J. Prom; Margaret J. Beatka; Jennifer L. Strande; Michael W. Lawlor. A long-term study evaluating the effects of nicorandil treatment on Duchenne muscular dystrophy-associated cardiomyopathy in mdx mice. J Cardiovasc Pharmacol Ther. 2022 Jan-Dec;27: 10742484221088655.. |
27. Melanie Gartz and Jennifer L. Strande. Optimizing the Differentiation of Cardiomyocytes from Human Induced Pluripotent-Derived Stem Cells. Methods Mol Biol. 2021;2319:51-60. |
28. Melanie Gartz; Margaret Beatka; Mariah J. Prom; Jennifer L. Strande; Michael W. Lawlor. Cardiomyocyte-produced miR-339-5p mediates pathology in Duchenne muscular dystrophy cardiomyopathy. Hum Mol Genet. 2021 Nov 16;30(23):2347-2361. |
29. Melanie Gartz; Chien-Wei Lin; Mark Sussman; Michael Lawlor and Jennifer L. Strande. Duchenne muscular dystrophy cardiomyocyte-secreted exosomes promote the pathogenesis of DMD-associated cardiomyopathy. Disease Models and Mechanisms, 2020 Nov 13;13(11):dmm045559. |
30. Melanie Gartz; Ashley Darlington; Zeeshan Afzal and Jennifer L. Strande. Exosomes exert cardioprotection in dystrophin-deficient cardiomyocytes via ERK1/2-p38/MAPK signaling. Scientific Reports, 2018 Jun 5; 7(11): e007954. |
31. Zeeshan Afzal; Melanie Gartz; Ekaterina A Klyachko; Sadiya S Khan; Sanjiv J Shah; Sweta Gupta; Amy D Shapiro; Douglas E Vaughan Jennifer L Strande. Generation of Human iPSCs from Urine Derived Cells of Patient with a Novel Heterozygous PAI-1 Mutation. Stem Cell Research, 2017 Jan;18:41-44. |
32. Zeeshan Afzal; Melanie Gartz; Ekaterina A Klyachko; Sadiya S Khan; Sanjiv J Shah; Sweta Gupta; Amy D Shapiro; Douglas E Vaughan Jennifer L Strande. Generation of Human iPSCs from Urine Derived Cells of Patient from a non-affected control subject. Stem Cell Research, 2017 Jan;18:33-36. |
33. Alison J. Kriegel; Melanie Gartz; Zeeshan Afzal; Willem J. De Lange; J. Carter Ralphe and Jennifer L. Strande. Molecular approaches to precision medicine in HFpEF: MicroRNAs and iPSC-derived cardiomyocytes. Journal of Cardiovasc Translational Research, 2016 Dec 28, 10:295-304. |
34. Zeeshan Afzal; Melanie Gartz; Ekaterina A Klyachko; Sadiya S Khan; Sanjiv J Shah; Sweta Gupta; Amy D Shapiro; Douglas E Vaughan and Jennifer L Strande. Generation of Human iPSCs from Urine Derived Cells of Patient with a Novel Homozygous PAI-1 Mutation. Stem Cell Research, 2016 Nov;17(3):657-660. |
35. Zeeshan Afzal*; Melanie Reiter*; Courtney Gastonguay,; Jered V. McGivern; Xuan Guan; Zhi-Dong Ge; David L. Mack; Martin K. Childers; Allison D. Ebert and Jennifer L. Strande. Nicorandil, a Nitric Oxide Donor and ATP-Sensitive Potassium Channel Opener, Protects Against Dystrophin-Deficient Cardiomyopathy. J Cardiovasc Pharmacol Ther. 2016 Nov;21(6):549-562. |
36. *Denotes co-first authorship |
Books, Chapters, and Reviews |
1. Melanie Gartz and Jennifer L. Strande. Examining the paracrine effects of exosomes in cardiovascular disease and repair. J Am Heart Assoc. 2018 Jun 1;7(11):e007954. |
2. Ngoc Lam; Melanie Gartz; Leah Thomas; Margaret Haberman; Jennifer L. Strande. Influence of microRNAs and exosomes in muscle health and disease. Journal of Muscle Research and Cell Motility, 2019 Sept;41(4):269-284. |
3. Melanie Gartz and Jennifer L. Strande. Optimizing the Differentiation of Cardiomyocytes from Human Induced Pluripotent-Derived Stem Cells. Methods Mol Biol. 2021;2319:51-60. |
4. Melanie Gartz and Jennifer L. Strande. Examining the paracrine effects of exosomes in cardiovascular disease and repair. J Am Heart Assoc. 2018 Jun 1;7(11):e007954. |
5. Ngoc Lam; Melanie Gartz; Leah Thomas; Margaret Haberman; Jennifer L. Strande. Influence of microRNAs and exosomes in muscle health and disease. Journal of Muscle Research and Cell Motility, 2019 Sept;41(4):269-284. |
6. Melanie Gartz and Jennifer L. Strande. Optimizing the Differentiation of Cardiomyocytes from Human Induced Pluripotent-Derived Stem Cells. Methods Mol Biol. 2021;2319:51-60. |
7. Melanie Gartz and Jennifer L. Strande. Examining the paracrine effects of exosomes in cardiovascular disease and repair. J Am Heart Assoc. 2018 Jun 1;7(11):e007954. |
8. Ngoc Lam; Melanie Gartz; Leah Thomas; Margaret Haberman; Jennifer L. Strande. Influence of microRNAs and exosomes in muscle health and disease. Journal of Muscle Research and Cell Motility, 2019 Sept;41(4):269-284. |
9. Melanie Gartz and Jennifer L. Strande. Optimizing the Differentiation of Cardiomyocytes from Human Induced Pluripotent-Derived Stem Cells. Methods Mol Biol. 2021;2319:51-60. |