CURRICULUM VITAE
Michael Lerch PhD
Michael Lerch PhD
Associate Professor
Department of Biophysics
Department of Biophysics
OFFICE ADDRESS: |
MACC Fund Research Center |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
Phone: 414-955-4787 |
Email: mlerch@mcw.edu |
EDUCATION: |
09/2004 - 05/2009 BS, University of San Francisco, San Francisco, CA |
09/2009 - 09/2015 PhD, University of California, Los Angeles (Advisor: Wayne L. Hubbell, PhD), Los Angeles, CA |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
10/2015 - 08/2017 Postdoctoral Fellow, Stein Eye Institute, University of California, Los Angeles (Advisor: Wayne L. Hubbell, PhD), Los Angeles, CA |
FACULTY APPOINTMENTS: |
09/2017 - 06/2024 Assistant Professor, Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI |
07/2024 - Present Associate Professor, Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI |
RESEARCH ADMINISTRATIVE APPOINTMENTS: |
02/2023 - Present Member, Cardiovascular Research Center, Medical College of Wisconsin |
12/2023 - Present Member, Cancer Center, Medical College of Wisconsin |
AWARDS AND HONORS: |
2004 - 2009 University Scholar's Scholarship, University of San Francisco |
2007 ACS Polymer Chemistry Award, University of San Francisco |
2009 Father Flynn Award (graduated first in class), University of San Francisco |
2009 Mel Gorman Award (top graduating Chemistry major), University of San Francisco |
2014 George Gregory Award for Graduate Research in Physical Chemistry, University of California, Los Angeles |
2016 JEOL Prize at the 49th Royal Society of Chemistry ESR Spectroscopy Group Meeting, University of Essex |
2019 - 2020 MCW Outstanding Graduate School Educator Award, Medical College of Wisconsin Graduate School |
2022 - 2023 MCW Outstanding Graduate School Educator Award, Medical College of Wisconsin Graduate School |
2023 James S. Hyde Research Award, Medical College of Wisconsin Department of Biophysics |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
2008 - Present American Society of Chemistry (Member) |
2011 - Present Biophysical Society (Member) |
2017 - Present International EPR Society (Member) |
2022 - Present Protein Society (Member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorship |
09/2023 - Present Frontiers in Chemistry |
Journal Review |
2019 - Present Chemistry Society Reviews |
2022 - Present Langmuir |
2022 - Present ACS Applied Materials & Interfaces |
2023 - Present Applied Magnetic Resonance |
Ad-Hoc Reviewer |
2022 - Present ETH Zurich Research Commission |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
Michael T. Lerch, Exploring protein conformational landscapes with site-directed spin labeling and pressure-resolved DEER, The 49th Annual International Meeting of the ESR Spectroscopy Group of the Royal Society of Chemistry, University of Essex, Colchester, United Kingdom, 04/03/2016 |
Michael T. Lerch, Exploring conformational flexibility in membrane proteins with high-pressure EPR, 10th International Workshop on EPR in Biology and Medicine, Krakow, Poland, 10/03/2016 |
Michael T. Lerch, Development of a high-pressure EPR toolkit for exploring protein conformational ensembles, International Virtual EPR Meeting seminar series, 04/28/2022 |
National |
Michael T. Lerch, Touring the conformational landscape of proteins with site-directed spin labeling EPR and pressure, Department of Molecular and Cellular Physiology special seminar, Stanford University, Stanford, CA, 01/30/2017 |
Michael T. Lerch, Using Pressure-Resolved SDSL-EPR to Tour the Protein Conformational Landscape, EPR Present and Future: Joint SPP1601/Shared EPR Conference, Mohonk Mountain House, New Paltz, NY, 10/09/2017 |
Michael T. Lerch, Development of a high-pressure EPR toolkit for exploring protein conformational ensembles, High Pressure Structural Biology and Extreme Biophysics Workshop, Cornell University, Ithaca, NY, 04/08/2022 |
Local |
Michael T. Lerch, Touring the conformational landscape of proteins with high-pressure SDSL-EPR spectroscopy, National Biomedical EPR Center’s EPR Workshop: EPR Methodologies Enabled by Loop-Gap Resonators, Medical College of Wisconsin, Milwaukee, WI, 08/21/2015 |
Michael T. Lerch, Mapping sparsely populated regions of the β2AR conformational landscape with pressure-resolved SDSL-EPR, Department of Biophysics Graduate Seminar Series, Medical College of Wisconsin, 04/20/2018 |
Michael T. Lerch, Mapping sparsely populated regions of the β2AR conformational landscape with pressure-resolved SDSL-EPR, Vision Science Forum and Social, Medical College of Wisconsin, 05/17/2018 |
Michael T. Lerch, Defining the structural basis of basal activity and biased agonism in GPCRs with DEER spectroscopy, Department of Biochemistry seminar series, Medical College of Wisconsin, 02/06/2019 |
Michael T. Lerch, The role of conformational selection in β2AR signaling, Department of Biophysics Graduate Seminar Series, Medical College of Wisconsin, 04/23/2021 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
International |
Matt RA, Masureel MM, Lerch MT, Ye L, Mahoney J, Huebner H, Clark MJ, Liu X, Manglik A, Stobel A, Korczynska M, Hilger D, Altenbach C, Zhang C, Sunahara R, Gmeiner P, Shoichet B, Prosser RS, Hubbell WL, Kobilka BK, Biophysical studies of β2-Adrenergic Receptor Allostery, Advanced EPR Summer School, European Federation of EPR spectroscopy, Berlin, Germany, 08/24/2015 - 08/31/2015 |
Lerch MT, Matt RA, Masureel M, Elgeti M, Hilger D, Foys B, Kobilka BK, Hubbell WL, Pressure-resolved DEER provides insight into the role of conformational selection in β2-Adrenergic Receptor signaling, The 49th Annual International Meeting of the ESR Spectroscopy Group of the Royal Society of Chemistry, University of Essex, Colchester, United Kingdom, 04/03/2016 - 04/07/2016 |
Wingler LM, Elgeti M, Skiba MA, McMahon C, Staus DP, Hilger D, Latorraca NR, Suomivuori CM, Lerch MT, Kleinhenz ALW, Kobilka BK, Dror RO, Hubbell WL, Kruse AC, Lefkowitz RJ, Molecular Mechanisms of Biased Signaling at the Angiotensin Receptor, International Union of Physiological Sciences Conference, Beijing, China (virtual), 05/07/2022 - 05/11/2022 |
Wingler LM, Elgeti M, Skiba MA, McMahon C, Staus DP, Hilger D, Latorraca NR, Suomivuori CM, Lerch MT, Kleinhenz ALW, Kobilka BK, Dror RO, Hubbell WL, Kruse AC, Lefkowitz RJ, Molecular Mechanisms of Biased Signaling at the Angiotensin Receptor, Annual Great Lakes GPCR Retreat. Niagara on the Lake, Ontario, Canada, 05/12/2022 - 05/14/2022 |
Brennan PC, Garces AM, Pani B, Lefkowitz RJ, Lerch MT, Pressure Resolved DEER to Define the Conformational Landscape Governing Ligand-Mediated β2-Adrenergic Receptor Signal Transduction, Annual Biophysical Society Meeting, San Diego, CA, USA, 02/17/2023 - 02/20/2023 |
National |
Lerch MT, Yang Z, Altenbach C, Ting E, Sidabras J, Anderson J, Hyde JS, Hubbell WL, Measuring protein conformational exchange rates with pressure-jump site directed spin labeling EPR spectroscopy, 56th Annual Meeting of the Biophysical Society, San Diego, CA, 02/25/2012 - 02/29/2012 |
Lerch MT, Yang Z, Brooks E, Hubbell WL, High-pressure conformational ensemble of apomyoglobin revealed by double electron-electron resonance, 27th Annual Symposium of the Protein Society, Boston, MA, 07/20/2013 - 07/23/2013 |
Lerch MT, Lopez C, Hubbell WL, Conformational flexibility and structure in high-pressure excited states of apomyoglobin revealed by SDSL-EPR, 58th Annual Meeting of the Biophysical Society, San Francisco, CA, 02/15/2014 - 02/19/2014 |
Matt RA, Masureel M, Lerch MT, Ye L, Mahoney J, Huebner H, Clark MJ, Liu X, Manglik A, Stobel A, Korczynska M, Hilger D, Altenbach C, Zhang C, Sunahara R, Gmeiner P, Shoichet B, Prosser RS, Hubbell WL, Kobilka BK, Biophysical studies of β2-Adrenergic Receptor Allostery, GPCR Workshop, Kona, HI, 12/02/2015 - 12/06/2015 |
Lerch MT, Kreitman M, Elgeti M, Yang Z, Altenbach C, Hubbell WL, Variable-pressure site-directed spin labeling EPR reveals local compressibility and conformational exchange in proteins, 60th Annual Meeting of the Biophysical Society, Los Angeles, CA, 02/27/2016 - 03/02/2016 |
Bergdoll LA, Lerch MT, Belardo K, Altenbach C, Bisignano P, Grabe M, Hubbell W, Abramson J, Ph-Induced Oligomerization of the Voltage Dependent Anion Channel, 61st Annual Meeting of the Biophysical Society, New Orleans, LA, 02/11/2017 - 02/15/2017 |
Bergdoll LA, Lerch MT, Patrick JW, Altenbach C, Bisignano P, Laganowsky A, Grabe M, Hubbell W, Abramson J, Protonation State of Glutamate 73 Regulates the Formation of a Unique Dimeric Association of VDAC1, 62nd Annual Meeting of the Biophysical Society, San Francisco, CA, 02/17/2018 - 02/21/2018 |
Wingler LM, Elgeti M, Skiba MA, McMahon C, Staus DP, Hilger D, Latorraca NR, Suomivuori CM, Lerch MT, Kleinhenz ALW, Kobilka BK, Dror RO, Hubbell WL, Kruse AC, Lefkowitz RJ, Molecular Mechanisms of Angiotensin Receptor Activation and Biased Signaling, Discovery on Target Conference, Boston, MA, 09/27/2018 - 09/28/2018 |
Wingler LM, Elgeti M, Skiba MA, McMahon C, Staus DP, Hilger D, Latorraca NR, Suomivuori CM, Lerch MT, Kleinhenz ALW, Kobilka BK, Dror RO, Hubbell WL, Kruse AC, Lefkowitz R, Molecular Mechanisms of Biased Agonism at the Angiotensin Receptor, Molecular Pharmacology Gordon Research Conference, Ventura, CA, 02/10/2019 - 02/15/2019 |
Wingler LM, Elgeti M, Skiba MA, McMahon C, Staus DP, Hilger D, Latorraca NR, Suomivuori CM, Lerch MT, Kleinhenz ALW, Kobilka BK, Dror RO, Hubbell WL, Kruse AC, Lefkowitz RJ, Insights into ligand mechanisms for "biasing" G protein-coupled receptor signaling, Illuminating the Druggable Genome Symposium (virtual), 09/10/2020 - 09/11/2020 |
Wingler LM, Elgeti M, Skiba MA, McMahon C, Staus DP, Hilger D, Latorraca NR, Suomivuori CM, Lerch MT, Kleinhenz ALW, Kobilka BK, Dror RO, Hubbell WL, Kruse AC, Lefkowitz RJ, Molecular Mechanisms of Biased Signaling at the Angiotensin Receptor, ASPET-APS-ASBMB Joint Colloquium on G Protein-Coupled Receptors (virtual), 05/11/2021 |
Wingler LM, Elgeti M, Skiba MA, McMahon C, Staus DP, Hilger D, Latorraca NR, Suomivuori CM, Lerch MT, Kleinhenz ALW, Kobilka BK, Dror RO, Hubbell WL, Kruse AC, Lefkowitz RJ, Molecular Mechanisms of Biased Signaling at the Angiotensin Receptor, Transatlantic GPCR Symposium for Early Career Investigators, Keynote Address (virtual), 07/08/2021 |
Wingler LM, Elgeti M, Skiba MA, McMahon C, Staus DP, Hilger D, Latorraca NR, Suomivuori CM, Lerch MT, Kleinhenz ALW, Kobilka BK, Dror RO, Hubbell WL, Kruse AC, Lefkowitz RJ, Illuminating the Role of Conformational Heterogeneity in GPCR Pharmacology, The Understudied Druggable Proteome, FASEB Science Research Conference (virtual), 08/10/2021 - 08/12/2021 |
Wingler LM, Elgeti M, Skiba MA, McMahon C, Staus DP, Hilger D, Latorraca NR, Suomivuori CM, Lerch MT, Kleinhenz ALW, Kobilka BK, Dror RO, Hubbell WL, Kruse AC, Lefkowitz RJ, Molecular Mechanisms of Biased Signaling at the Angiotensin Receptor, ASBMB Annual Meeting at EB 2022, Philadelphia, PA, 04/02/2022 - 04/05/2022 |
Casiraghi M, Wang H, Brenna P, Hubner H, Schmidt M, Pani B, White E, Sunahara R, Lefkowitz RJ, Gmeiner P, Lerch MT, Kobilka BK, Investigation of G-protein specificity and bias agonism at the b2-adrenergic receptor, GPCRs: an odyssey from structure signaling and regulation to therapeutics (Keystone Symposium), Snowbird, UT, 04/06/2022 - 04/09/2022 |
Wingler LM, Elgeti M, Skiba MA, McMahon C, Staus DP, Hilger D, Latorraca NR, Suomivuori CM, Lerch MT, Kleinhenz ALW, Kobilka BK, Dror RO, Hubbell WL, Kruse AC, Lefkowitz RJ, Molecular Mechanisms of Biased Signaling at the Angiotensin Receptor, The G Protein-Coupled Receptor Kinases and Arrestins Conference (FASEB), Jupiter, FL, 08/21/2022 - 08/26/2022 |
Brennan PC, Pani B, Casiraghi M, Lefkowitz RJ, Kobilka BK, Lerch MT, DEER Spectroscopy Demonstrates the Link Between Conformational Heterogeneity and the Signaling Efficacy and Bias of Ligands for the Beta-2-Adrenergic Receptor (β2AR), Annual Rocky Mountain Conference, Denver, CO, USA, 07/23/2023 - 07/27/2023 |
Grosskopf JD, Altenbach C, Sidabras J, Anderson J, Mett R, Strangeway R, Hyde J, Hubbell W, Lerch MT, Characterization of protein conformational exchange kinetics using pressure-jump EPR, Rocky Mountain conference on Magnetic Resonance, Denver, CO, USA, 07/23/2023 - 07/27/2023 |
Garces AM, Brennan PC, Pani B, Lefkowitz RJ, Lerch MT, Defining The Conformational Landscape Governing Ligand-Mediated β2 Adrenergic Receptor Signaling Using Pressure Resolved Double Electron Electron Resonance (PR-DEER) Spectroscopy, Rocky Mountain Conference on Magnetic Resonance, Denver, CO, USA, 07/23/2023 - 07/27/2023 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
11/2020 - Present Department Representative, IDP Recruitment, Medical College of Wisconsin |
09/01/2021 - 08/31/2024 Academic Unit Representative, Faculty Council, Medical College of Wisconsin |
07/01/2022 - 06/30/2025 Elected Member, Curriculum and Programs Committee, Medical College of Wisconsin |
07/01/2022 - 06/30/2025 Provost’s Appointee, Library Committee, Medical College of Wisconsin |
01/2023 - Present Faculty Member, Information Technology Committee |
11/22/2023 - Present Faculty Member, Library Director Search Committee, Medical College of Wisconsin |
MCW TEACHING ACTIVITIES: |
Graduate Student Education |
09/2017 - 09/2018 IDP Graduate Student Lunch Series speaker; “Revealing molecular mechanisms of protein function with site-directed spin labeling EPR” |
09/2019 - Present Foundations of Biomedical Sciences I (#16215); “Physical and chemical properties of functional groups: proteins” |
09/2020 - Present Biophysical Techniques in Biochemistry (#03226); “Biomolecular hydrodynamics and AUC” |
01/2021 - Present EPR Journal Club (#03298); course director |
09/2021 - Present Introduction to Magnetic Resonance: Electron Paramagnetic Resonance (EPR) (#03223);“Experimental Basics of Continuous Wave (CW) EPR,” “Site-directed spin-labeling: methods and applications,” “Pulse EPR Spectroscopy I: Theory,” and “Pulse EPR Spectroscopy II: Applications” |
EXTRAMURAL TEACHING: |
Graduate Student Education |
07/17/2019 - 07/21/2019 International EPR Society & Shared EPR Summer School 2019, University of Denver, Denver, CO, “Experimental basics of continuous-wave EPR” |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Undergraduate Students |
05/30/2018 - 08/03/2018 Jessica Jurak, Summer Program for Undergraduate Research (SPUR), Medical College of Wisconsin, Currently a student at Kentucky College of Osteopathic Medicine at the University of Pikeville |
Graduate Students |
PhD Students Advised |
07/09/2018 - 08/03/2018 Nicholas Malcolm, Rotation Student: MSTP, Medical College of Wisconsin |
07/2019 - Present Alexander Garces, Structural and Kinetic Insights into the β2-Adrenergic Receptor Encounter Complex with Gs, Medical College of Wisconsin |
08/2019 - Present Patrick Brennan, Structural Basis for Regulation of β2 Adrenergic Receptor Signaling by the Dynamic Post-Translational Modification S-palmitoylation, Medical College of Wisconsin |
11/04/2019 - 12/13/2019 Gage Stuttgen, Rotation Student, Medical College of Wisconsin |
07/2021 - Present Julian Grosskopf, Modulation of β2 Adrenergic Receptor Structure and Dynamics by Protein-Lipid Interactions, Medical College of Wisconsin |
09/25/2023 - 11/03/2023 Cassandra Zehr, Medical College of Wisconsin, Rotation Student: IDP Graduate Student |
PhD Committees |
2021 - Present Nicholas Malcolm, MSTP, IDP Graduate Student in the laboratory of John McCorvy, Department of Biochemistry, Medical College of Wisconsin |
MCW RESEARCH TECHNOLOGISTS MENTORED: |
11/2017 - 12/2020 Christine Jennings, Entered IDP at MCW |
08/2020 - 05/2022 Anjana Adhikari, Entered the Environmental Health Sciences graduate program at the University of Wisconsin-Milwaukee |
05/2022 - Present Dylan Pawlak |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Johansen E, Schilling B, Lerch M, Niles RK, Liu H, Li B, Allen S, Hall SC, Witkowska HE, Regnier FE, Gibson BW, Fisher SJ, Drake PM. A lectin HPLC method to enrich selectively-glycosylated peptides from complex biological samples. J Vis Exp. 2009 Oct 01(32). PMCID: PMC2762330 |
2. Drake PM, Schilling B, Niles RK, Braten M, Johansen E, Liu H, Lerch M, Sorensen DJ, Li B, Allen S, Hall SC, Witkowska HE, Regnier FE, Gibson BW, Fisher SJ. A lectin affinity workflow targeting glycosite-specific, cancer-related carbohydrate structures in trypsin-digested human plasma. Anal Biochem. 2011 Jan 01;408(1):71-85. PMCID: PMC3205961 |
3. Lerch MT, Horwitz J, McCoy J, Hubbell WL. Circular dichroism and site-directed spin labeling reveal structural and dynamical features of high-pressure states of myoglobin. Proc Natl Acad Sci U S A. 2013 Dec 03;110(49):E4714-22. PMCID: PMC3856799 |
4. Lerch MT, Yang Z, Brooks EK, Hubbell WL. Mapping protein conformational heterogeneity under pressure with site-directed spin labeling and double electron-electron resonance. Proc Natl Acad Sci U S A. 2014 Apr 01;111(13):E1201-10. PMCID: PMC3977274 |
5. Lerch MT, López CJ, Yang Z, Kreitman MJ, Horwitz J, Hubbell WL. Structure-relaxation mechanism for the response of T4 lysozyme cavity mutants to hydrostatic pressure. Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2437-46. PMCID: PMC4434698 |
6. Manglik A, Kim TH, Masureel M, Altenbach C, Yang Z, Hilger D, Lerch MT, Kobilka TS, Thian FS, Hubbell WL, Prosser RS, Kobilka BK. Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling. Cell. 2015 May 21;161(5):1101-1111. PMCID: PMC4441853 |
7. Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE. SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins. Science. 2015 Jun 19;348(6241):1361-5. PMCID: PMC4968074 |
8. Bergdoll LA, Lerch MT, Patrick JW, Belardo K, Altenbach C, Bisignano P, Laganowsky A, Grabe M, Hubbell WL, Abramson J. Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1. Proc Natl Acad Sci U S A. 2018 Jan 09;115(2):E172-E179. PMCID: PMC5777057 |
9. Stadtmueller BM, Bridges MD, Dam KM, Lerch MT, Huey-Tubman KE, Hubbell WL, Bjorkman PJ. DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions. Immunity. 2018 Aug 21;49(2):235-246.e4. PMCID: PMC6104740 |
10. Wingler LM, Elgeti M, Hilger D, Latorraca NR, Lerch MT, Staus DP, Dror RO, Kobilka BK, Hubbell WL, Lefkowitz RJ. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell. 2019 Jan 24;176(3):468-478.e11. PMCID: PMC6475118 |
11. Lerch MT, Matt RA, Masureel M, Elgeti M, Kumar KK, Hilger D, Foys B, Kobilka BK, Hubbell WL. Viewing rare conformations of the β<sub>2</sub> adrenergic receptor with pressure-resolved DEER spectroscopy. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):31824-31831. PMCID: PMC7749303 |
12. Hilger D, Kumar KK, Hu H, Pedersen MF, O'Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK. Structural insights into differences in G protein activation by family A and family B GPCRs. Science. 2020 Jul 31;369(6503). PMCID: PMC7954662 |
Books, Chapters, and Reviews |
1. Yang Z, Bridges M, Lerch MT, Altenbach C, Hubbell WL. Saturation Recovery EPR and Nitroxide Spin Labeling for Exploring Structure and Dynamics in Proteins. Methods Enzymol. 2015;564:3-27. |
2. Lerch MT, Yang Z, Altenbach C, Hubbell WL. High-Pressure EPR and Site-Directed Spin Labeling for Mapping Molecular Flexibility in Proteins. Methods Enzymol. 2015;564:29-57. |
3. Klug CS, Lerch MT, Feix JB. Applications of Nitroxide Spin Labels to Structural Biology. Nitroxides: Synthesis, Properties, and Applications. Ed. Ouari O, Gigmes D. 2021. |
4. Brennan P, Grosskopf J, Garces A, Lerch MT. Elucidating Protein Structural Heterogeneity and Dynamics with Electron Paramagnetic Resonance Spectroscopy. Current Opinion in Structural Biology. Invited submission to the section on Biophysical Methods in 2025. |
5. Casiraghi M, Wang H, Brennan P, Habrian C, Hubner H, Schmidt MF, Maul L, Pani B, Bahriz SM, Xu B, White E, Sunahara RK, Xiang YK, Lefkowitz RJ, Isacoff EY, Nucci N, Gmeiner P, Lerch M, Kobilka BK. Structure and dynamics determine G protein coupling specificity at a class A GPCR. bioRxiv. 2024 Apr 12. PMCID: PMC10996611 |
6. Grosskopf JD, Sidabras JW, Altenbach C, Anderson JR, Mett RR, Strangeway RA, Hyde JS, Hubbell WL, Lerch MT. A pressure-jump EPR system to monitor millisecond conformational exchange rates of spin-labeled proteins. bioRxiv. 2024 May 11. PMCID: PMC11100676 |
7. Grosskopf JD, Sidabras JW, Altenbach C, Anderson JR, Mett RR, Strangeway RA, Hyde JS, Hubbell WL, Lerch MT. A pressure-jump EPR system to monitor millisecond conformational exchange rates of spin-labeled proteins. Protein Sci. 2024 Dec;33(12):e5220. PMCID: PMC11577460 |
